WNT3A

Summary

Gene Symbol: WNT3A
Description: Wnt family member 3A
Alias: protein Wnt-3a, wingless-type MMTV integration site family, member 3A
Species: human
Products:     WNT3A

Top Publications

  1. Davidson K, Jamshidi P, Daly R, Hearn M, Pera M, Dottori M. Wnt3a regulates survival, expansion, and maintenance of neural progenitors derived from human embryonic stem cells. Mol Cell Neurosci. 2007;36:408-15 pubmed
    ..In addition, neurosphere formation and size were significantly greater in the presence of exogenous Wnt3a compared to control conditions...
  2. Tauriello D, Haegebarth A, Kuper I, Edelmann M, Henraat M, Canninga Van Dijk M, et al. Loss of the tumor suppressor CYLD enhances Wnt/beta-catenin signaling through K63-linked ubiquitination of Dvl. Mol Cell. 2010;37:607-19 pubmed publisher
    ..Together, our results argue that loss of CYLD instigates tumor growth in human cylindromatosis through a mechanism in which hyperubiquitination of polymerized Dvl drives enhancement of Wnt responses...
  3. Gazit A, Yaniv A, Bafico A, Pramila T, Igarashi M, Kitajewski J, et al. Human frizzled 1 interacts with transforming Wnts to transduce a TCF dependent transcriptional response. Oncogene. 1999;18:5959-66 pubmed
    ..All of these findings provide strong evidence that Hfz1 is a functional partner for certain Wnts in inducing TCF dependent transcription. ..
  4. Liu J, Ding X, Tang J, Cao Y, Hu P, Zhou F, et al. Enhancement of canonical Wnt/β-catenin signaling activity by HCV core protein promotes cell growth of hepatocellular carcinoma cells. PLoS ONE. 2011;6:e27496 pubmed publisher
    ..HCV core protein significantly enhances Tcf-dependent transcriptional activity induced by Wnt3A in HCC cell lines...
  5. Nalesso G, Sherwood J, Bertrand J, Pap T, Ramachandran M, De Bari C, et al. WNT-3A modulates articular chondrocyte phenotype by activating both canonical and noncanonical pathways. J Cell Biol. 2011;193:551-64 pubmed publisher
    ..We propose a novel model in which a single WNT can simultaneously activate different pathways with distinct and independent outcomes and with reciprocal regulation. This offers an opportunity for selective pharmacological targeting...
  6. Vijayaragavan K, Szabo E, Bosse M, Ramos Mejia V, Moon R, Bhatia M. Noncanonical Wnt signaling orchestrates early developmental events toward hematopoietic cell fate from human embryonic stem cells. Cell Stem Cell. 2009;4:248-62 pubmed publisher
    ..We demonstrate that activation of canonical Wnt signaling by Wnt3a promotes proliferation of human embryonic stem cells (hESCs)--precursors already committed to the hematopoietic ..
  7. Lu W, Yamamoto V, Ortega B, Baltimore D. Mammalian Ryk is a Wnt coreceptor required for stimulation of neurite outgrowth. Cell. 2004;119:97-108 pubmed
    ..Thus, Ryk appears to play a crucial role in Wnt-mediated signaling. ..
  8. Naschberger A, Orry A, Lechner S, Bowler M, Nurizzo D, Novokmet M, et al. Structural Evidence for a Role of the Multi-functional Human Glycoprotein Afamin in Wnt Transport. Structure. 2017;: pubmed publisher
    ..binding pocket of afamin was modeled as palmitoleic acid, presenting the native O-acylation on serine 209 in human Wnt3a. The modeled complex between the experimental afamin structure and a Wnt3a homology model based on the XWnt8-Fz8-..
  9. Niell N, Larriba M, Ferrer Mayorga G, Sanchez Perez I, Cantero R, Real F, et al. The human PKP2/plakophilin-2 gene is induced by Wnt/β-catenin in normal and colon cancer-associated fibroblasts. Int J Cancer. 2017;: pubmed publisher
    ..Here we present the first transcriptomic study on the effect of a Wnt factor on human colonic myofibroblasts. Wnt3A regulates the expression of 1,136 genes, of which 662 are upregulated and 474 are downregulated in CCD-18Co cells...
  10. Feng Y, Ren J, Gui Y, Wei W, Shu B, Lu Q, et al. Wnt/β-Catenin-Promoted Macrophage Alternative Activation Contributes to Kidney Fibrosis. J Am Soc Nephrol. 2018;29:182-193 pubmed publisher
    ..Treatment of macrophages with Wnt3a exacerbated IL-4- or TGFβ1-induced macrophage alternative (M2) polarization and the phosphorylation and ..

Detail Information

Publications62

  1. Davidson K, Jamshidi P, Daly R, Hearn M, Pera M, Dottori M. Wnt3a regulates survival, expansion, and maintenance of neural progenitors derived from human embryonic stem cells. Mol Cell Neurosci. 2007;36:408-15 pubmed
    ..In addition, neurosphere formation and size were significantly greater in the presence of exogenous Wnt3a compared to control conditions...
  2. Tauriello D, Haegebarth A, Kuper I, Edelmann M, Henraat M, Canninga Van Dijk M, et al. Loss of the tumor suppressor CYLD enhances Wnt/beta-catenin signaling through K63-linked ubiquitination of Dvl. Mol Cell. 2010;37:607-19 pubmed publisher
    ..Together, our results argue that loss of CYLD instigates tumor growth in human cylindromatosis through a mechanism in which hyperubiquitination of polymerized Dvl drives enhancement of Wnt responses...
  3. Gazit A, Yaniv A, Bafico A, Pramila T, Igarashi M, Kitajewski J, et al. Human frizzled 1 interacts with transforming Wnts to transduce a TCF dependent transcriptional response. Oncogene. 1999;18:5959-66 pubmed
    ..All of these findings provide strong evidence that Hfz1 is a functional partner for certain Wnts in inducing TCF dependent transcription. ..
  4. Liu J, Ding X, Tang J, Cao Y, Hu P, Zhou F, et al. Enhancement of canonical Wnt/β-catenin signaling activity by HCV core protein promotes cell growth of hepatocellular carcinoma cells. PLoS ONE. 2011;6:e27496 pubmed publisher
    ..HCV core protein significantly enhances Tcf-dependent transcriptional activity induced by Wnt3A in HCC cell lines...
  5. Nalesso G, Sherwood J, Bertrand J, Pap T, Ramachandran M, De Bari C, et al. WNT-3A modulates articular chondrocyte phenotype by activating both canonical and noncanonical pathways. J Cell Biol. 2011;193:551-64 pubmed publisher
    ..We propose a novel model in which a single WNT can simultaneously activate different pathways with distinct and independent outcomes and with reciprocal regulation. This offers an opportunity for selective pharmacological targeting...
  6. Vijayaragavan K, Szabo E, Bosse M, Ramos Mejia V, Moon R, Bhatia M. Noncanonical Wnt signaling orchestrates early developmental events toward hematopoietic cell fate from human embryonic stem cells. Cell Stem Cell. 2009;4:248-62 pubmed publisher
    ..We demonstrate that activation of canonical Wnt signaling by Wnt3a promotes proliferation of human embryonic stem cells (hESCs)--precursors already committed to the hematopoietic ..
  7. Lu W, Yamamoto V, Ortega B, Baltimore D. Mammalian Ryk is a Wnt coreceptor required for stimulation of neurite outgrowth. Cell. 2004;119:97-108 pubmed
    ..Thus, Ryk appears to play a crucial role in Wnt-mediated signaling. ..
  8. Naschberger A, Orry A, Lechner S, Bowler M, Nurizzo D, Novokmet M, et al. Structural Evidence for a Role of the Multi-functional Human Glycoprotein Afamin in Wnt Transport. Structure. 2017;: pubmed publisher
    ..binding pocket of afamin was modeled as palmitoleic acid, presenting the native O-acylation on serine 209 in human Wnt3a. The modeled complex between the experimental afamin structure and a Wnt3a homology model based on the XWnt8-Fz8-..
  9. Niell N, Larriba M, Ferrer Mayorga G, Sanchez Perez I, Cantero R, Real F, et al. The human PKP2/plakophilin-2 gene is induced by Wnt/β-catenin in normal and colon cancer-associated fibroblasts. Int J Cancer. 2017;: pubmed publisher
    ..Here we present the first transcriptomic study on the effect of a Wnt factor on human colonic myofibroblasts. Wnt3A regulates the expression of 1,136 genes, of which 662 are upregulated and 474 are downregulated in CCD-18Co cells...
  10. Feng Y, Ren J, Gui Y, Wei W, Shu B, Lu Q, et al. Wnt/β-Catenin-Promoted Macrophage Alternative Activation Contributes to Kidney Fibrosis. J Am Soc Nephrol. 2018;29:182-193 pubmed publisher
    ..Treatment of macrophages with Wnt3a exacerbated IL-4- or TGFβ1-induced macrophage alternative (M2) polarization and the phosphorylation and ..
  11. Berwick D, Harvey K. The importance of Wnt signalling for neurodegeneration in Parkinson's disease. Biochem Soc Trans. 2012;40:1123-8 pubmed
    ..This suggests the prospect of targeting Wnt signalling pathways to modify PD progression. ..
  12. Hübner K, Grassme K, Rao J, Wenke N, Zimmer C, Korte L, et al. Wnt signaling positively regulates endothelial cell fate specification in the Fli1a-positive progenitor population via Lef1. Dev Biol. 2017;430:142-155 pubmed publisher
    ..Additionally, we show that mesodermal Wnt3a-mediated signaling via the transcription factor Lef1 positively regulates EC specification (defined by kdrl ..
  13. Benham Pyle B, Sim J, Hart K, PRUITT B, NELSON W. Increasing β-catenin/Wnt3A activity levels drive mechanical strain-induced cell cycle progression through mitosis. elife. 2016;5: pubmed publisher
    ..Activating β-catenin through Casein Kinase I inhibition or Wnt3A addition increased β-catenin-mediated transcription and strain-induced accumulation of cells in S/G2...
  14. Le L, Swingler T, Crowe N, Vincent T, Barter M, Donell S, et al. The microRNA-29 family in cartilage homeostasis and osteoarthritis. J Mol Med (Berl). 2016;94:583-96 pubmed publisher
    ..The miR-29 family is regulated by TGF-β1 and IL-1 in chondrocytes. The miR-29 family negatively regulates Smad, NFκB, and canonical Wnt signalling. Several Wnt-related genes are direct targets of the miR-29 family. ..
  15. Xu T, Pan L, Ge Y, Li P, Meng X, Huang C, et al. TMEM88 mediates inflammatory cytokines secretion by regulating JNK/P38 and canonical Wnt/β-catenin signaling pathway in LX-2 cells. Inflammopharmacology. 2017;: pubmed publisher
    ..could increase the expression levels of canonical Wnt/β-catenin accompanied with upregulated phosphorylation of wnt3a, wnt10b and β-catenin protein levels in response to TNF-α...
  16. Sindhavajiva P, Sastravaha P, Arksornnukit M, Pavasant P. Intermittent compressive force induces human mandibular-derived osteoblast differentiation via WNT/β-catenin signaling. J Cell Biochem. 2017;: pubmed publisher
    ..In addition, OSX, ALP, and WNT3A mRNA expression and β-catenin nuclear translocation increased when ICF was applied...
  17. Hocevar B, Mou F, Rennolds J, Morris S, Cooper J, Howe P. Regulation of the Wnt signaling pathway by disabled-2 (Dab2). EMBO J. 2003;22:3084-94 pubmed
    ..Based on these results, we propose that Dab2 functions as a negative regulator of canonical Wnt signaling by stabilizing the beta-catenin degradation complex, which may contribute to its proposed role as a tumor suppressor. ..
  18. Yang E, Tacchelly Benites O, Wang Z, Randall M, Tian A, Benchabane H, et al. Wnt pathway activation by ADP-ribosylation. Nat Commun. 2016;7:11430 pubmed publisher
    ....
  19. Kaur N, Chettiar S, Rathod S, Rath P, Muzumdar D, Shaikh M, et al. Wnt3a mediated activation of Wnt/β-catenin signaling promotes tumor progression in glioblastoma. Mol Cell Neurosci. 2013;54:44-57 pubmed publisher
    ..We demonstrate that Wnt ligands - Wnt1 and Wnt3a are expressed in a graded manner in these tumors as well as over-expressed in glioma stem cell-lines...
  20. Korvala J, Löija M, Makitie O, Sochett E, Juppner H, Schnabel D, et al. Rare variations in WNT3A and DKK1 may predispose carriers to primary osteoporosis. Eur J Med Genet. 2012;55:515-9 pubmed publisher
    ..The genes studied included DKK1, DKK2, WNT3A, WNT10B, AXIN1, SOST, TPH1 and 5-HTR1B. Two rare variants in WNT3A (c.152A > G, p.K51R) and DKK1 (c...
  21. Johnson R, Merkel A, Page J, Ruppender N, Guelcher S, Sterling J. Wnt signaling induces gene expression of factors associated with bone destruction in lung and breast cancer. Clin Exp Metastasis. 2014;31:945-59 pubmed publisher
    ..levels in MDA-MB-231 and RWGT2 cells in vitro and promoted tumor-induced bone destruction in vivo in a β-catenin/Wnt3a-dependent mechanism...
  22. Xing Y, Ma X, Guo H, Deng F, Yang J, Li Y. Wnt5a Suppresses β-catenin Signaling during Hair Follicle Regeneration. Int J Med Sci. 2016;13:603-10 pubmed publisher
    ..cell line and found that the inhibitory effect of Wnt5a on cell proliferation could be rescued by the addition of Wnt3a. Our data reveal that Wnt5a suppresses the activation of β-catenin signaling during hair follicle regeneration.
  23. Lian W, Wu R, Lee M, Chen Y, Sun Y, Wu S, et al. Subchondral mesenchymal stem cells from osteoarthritic knees display high osteogenic differentiation capacity through microRNA-29a regulation of HDAC4. J Mol Med (Berl). 2017;95:1327-1340 pubmed publisher
    ..They also displayed higher expressions of embryonic stem cell marker OCT3/4 and osteogenic factors Wnt3a, β-catenin, and microRNA-29a (miR-29a), concomitant with lower expressions of joint-deleterious factors HDAC4, ..
  24. Yang X, He H, Gao Q, He C. Pulsed electromagnetic field improves subchondral bone microstructure in knee osteoarthritis rats through a Wnt/β-catenin signaling-associated mechanism. Bioelectromagnetics. 2017;: pubmed publisher
    ..Real-time PCR analysis showed that PEMF promoted tibial subchondral bone's gene expressions of Wnt3a, β-catenin, and OPG, but did not alter LRP5 and RANKL mRNA levels...
  25. Zhang X, Ren J, Wang J, Li S, Zou Q, Gao N. Receptor-mediated endocytosis generates nanomechanical force reflective of ligand identity and cellular property. J Cell Physiol. 2017;: pubmed publisher
    ..Interestingly, two different growth factors, EGF and Wnt3a, elicited distinct elastic force profiles revealed by AFM at the plasma membrane during receptor-mediated ..
  26. Lei T, Liang Z, Li F, Tang C, Xie K, Wang P, et al. Pulsed electromagnetic fields (PEMF) attenuate changes in vertebral bone mass, architecture and strength in ovariectomized mice. Bone. 2017;108:10-19 pubmed publisher
    ..Real-time PCR showed that the canonical Wnt signaling pathway of the lumbar vertebrae, including Wnt3a, LRP5 and β-catenin were markedly up-regulated in OVX+PEMF group compared with OVX group...
  27. Steele B, Harper M, Macaulay I, Morrell C, Perez Tamayo A, Foy M, et al. Canonical Wnt signaling negatively regulates platelet function. Proc Natl Acad Sci U S A. 2009;106:19836-41 pubmed publisher
    ..We demonstrate that the Wnt3a ligand inhibits platelet adhesion, activation, dense granule secretion, and aggregation...
  28. Khan Z, Vijayakumar S, de la Torre T, Rotolo S, Bafico A. Analysis of endogenous LRP6 function reveals a novel feedback mechanism by which Wnt negatively regulates its receptor. Mol Cell Biol. 2007;27:7291-301 pubmed
    ..In light of the direct role that the Wnt pathway plays in human bone diseases and malignancies, our findings may support the development of novel therapeutic approaches that target Wnt signaling through LRP6. ..
  29. Gao Y, Wang H. Inositol pentakisphosphate mediates Wnt/beta-catenin signaling. J Biol Chem. 2007;282:26490-502 pubmed
    b>Wnt3a stimulates lymphoid enhancer factor/T-cell factor protein-sensitive transcription, i.e. the canonical pathway, in mouse F9 embryonal tetratocarcinoma cells expressing rat Frizzled-1...
  30. Zhang X, Hu D, Lu Y, Feng T, Huang J. [Overexpression of Wnt3a inhibited the apoptosis of mouse embryonic liver stem cells]. Xi Bao Yu Fen Zi Mian Yi Xue Za Zhi. 2013;29:1277-80 pubmed
    To study the effect of Wnt3a on the apoptosis and the expressions of apoptosis-related proteins in mouse embryonic liver stem cells (ELSCs). The mouse ELSC14...
  31. Rajan S, Puri S, Kumar D, Babu M, Shankar K, Varshney S, et al. Novel indole and triazole based hybrid molecules exhibit potent anti-adipogenic and antidyslipidemic activity by activating Wnt3a/β-catenin pathway. Eur J Med Chem. 2018;143:1345-1360 pubmed publisher
    ..The mechanistic study suggests that compound 13m exhibit anti-adipogenic property by activating Wnt3a/β-catenin pathway, a known suppressor of key adipogenic genes PPARγ and C/EBPα...
  32. Li X, PLACENCIO V, Iturregui J, Uwamariya C, Sharif Afshar A, Koyama T, et al. Prostate tumor progression is mediated by a paracrine TGF-beta/Wnt3a signaling axis. Oncogene. 2008;27:7118-30 pubmed publisher
    ..LNCaP cell proliferation and tumorigenesis was observed by Tgfbr2(fspKO) prostate stroma as a result of elevated Wnt3a expression. Neutralizing antibodies to Wnt3a reversed LNCaP tumorigenesis...
  33. Zhang J, Li Y, Liu Q, Lu W, Bu G. Wnt signaling activation and mammary gland hyperplasia in MMTV-LRP6 transgenic mice: implication for breast cancer tumorigenesis. Oncogene. 2010;29:539-49 pubmed publisher
    ..Our results suggest that Wnt signaling activation at the cell-surface receptor level can contribute to breast cancer tumorigenesis. ..
  34. Li N, Fu H, Hewitt S, Dimitrov D, Ho M. Therapeutically targeting glypican-2 via single-domain antibody-based chimeric antigen receptors and immunotoxins in neuroblastoma. Proc Natl Acad Sci U S A. 2017;114:E6623-E6631 pubmed publisher
    ..the single-domain antibodies can inhibit active β-catenin signaling by disrupting the interaction of GPC2 and Wnt3a. To explore GPC2 as a potential target in neuroblastoma, we have developed two forms of antibody therapeutics, ..
  35. Mihara E, Hirai H, Yamamoto H, Tamura Kawakami K, Matano M, Kikuchi A, et al. Active and water-soluble form of lipidated Wnt protein is maintained by a serum glycoprotein afamin/α-albumin. elife. 2016;5: pubmed publisher
    ..We purified N-terminally tagged recombinant Wnt3a secreted from cells and accidentally discovered that Wnt3a co-purified with a glycoprotein afamin derived from the ..
  36. Steele B, Harper M, Smolenski A, Alkazemi N, Poole A, Fitzgerald D, et al. WNT-3a modulates platelet function by regulating small GTPase activity. FEBS Lett. 2012;586:2267-72 pubmed publisher
    ..Upon pre-treatment with WNT-3a, this complex disassociates, concurrent with a reduction in RhoA-GTP. Together these data implicate WNT-3a as a novel upstream regulator of small GTPase activity in platelets. ..
  37. Skalka N, Caspi M, Lahav Ariel L, Loh Y, Hirschberg K, Rosin Arbesfeld R. Carboxypeptidase E (CPE) inhibits the secretion and activity of Wnt3a. Oncogene. 2016;35:6416-6428 pubmed publisher
    ..Here, we show that CPE and the Wnt3a ligand are co-secreted from cells...
  38. Rahman S, Park C, Baek J, Ryoo H, Woo K. Fibrin-Enhanced Canonical Wnt Signaling Directs Plasminogen Expression in Cementoblasts. Int J Mol Sci. 2017;18: pubmed publisher
    ..The OCCM30-fibrin showed higher levels of Wnt3a expression, nuclear translocation of β-catenin, and T-cell factor (TCF) optimal motif (TOP) reporter activity ..
  39. Moore W, Kern J, Bhat R, Commons T, Fukayama S, Goljer I, et al. Modulation of Wnt signaling through inhibition of secreted frizzled-related protein I (sFRP-1) with N-substituted piperidinyl diphenylsulfonyl sulfonamides. J Med Chem. 2009;52:105-16 pubmed publisher
    ..Details of the structure-activity relationships and biological activity from the first structural class of this scaffold will be discussed. ..
  40. Han Y, Liu T, Zou Y, Ji L, Li Y, Li J, et al. Proinsulin Promotes Self-Renewal of a Hematopoietic Progenitor Cell Line In Vitro. J Diabetes Res. 2017;2017:5649191 pubmed publisher
    ..Furthermore, Wnt3a can significantly promote self-renewal of Pro-INS + EML cells...
  41. Wang Z, Wan X, Sang G, Zhao J, Zhu Q, Wang D. miR-15a-5p suppresses endometrial cancer cell growth via Wnt/β-catenin signaling pathway by inhibiting WNT3A. Eur Rev Med Pharmacol Sci. 2017;21:4810-4818 pubmed
    ..The global incidence has increased in recent years. microRNAs (miRNAs) regulate numerous biological processes by binding to the 3'UTR of target mRNA to down-regulate protein synthesis...
  42. Maubant S, Tesson B, Maire V, Ye M, Rigaill G, Gentien D, et al. Transcriptome analysis of Wnt3a-treated triple-negative breast cancer cells. PLoS ONE. 2015;10:e0122333 pubmed publisher
    ..The treatment of cells with Wnt3a for 6h up-regulated the expression (fold change > 1...
  43. Lin S, Jiang T, Ye L, Han Z, Liu Y, Liu C, et al. The chromatin-remodeling enzyme BRG1 promotes colon cancer progression via positive regulation of WNT3A. Oncotarget. 2016;7:86051-86063 pubmed publisher
    ..The expression pattern of WNT3A is consistent with BRG1 in colon cancer tissues and WNT3A expression was inhibited in BRG1 knockdown cells...
  44. Hara K, Kageji T, Mizobuchi Y, Kitazato K, Okazaki T, Fujihara T, et al. Blocking of the interaction between Wnt proteins and their co-receptors contributes to the anti-tumor effects of adenovirus-mediated DKK3 in glioblastoma. Cancer Lett. 2015;356:496-505 pubmed publisher
    ..We first demonstrated the non-specific interaction of Wnt3a and Wnt5a with the receptors LRP6 and ROR2 and the up-regulation of the Wnt pathway in glioblastoma cells...
  45. Qiang Y, Chen Y, Stephens O, Brown N, Chen B, Epstein J, et al. Myeloma-derived Dickkopf-1 disrupts Wnt-regulated osteoprotegerin and RANKL production by osteoblasts: a potential mechanism underlying osteolytic bone lesions in multiple myeloma. Blood. 2008;112:196-207 pubmed publisher
    ..We demonstrate here that MM cell-derived DKK1, a soluble inhibitor of canonical Wnt signaling, disrupted Wnt3a-regulated OPG and RANKL expression in osteoblasts...
  46. Narendra Talabattula V, Morgan P, Frech M, Uhrmacher A, Herchenröder O, Pützer B, et al. Non-canonical pathway induced by Wnt3a regulates β-catenin via Pyk2 in differentiating human neural progenitor cells. Biochem Biophys Res Commun. 2017;491:40-46 pubmed publisher
    ..In this study, we showed that Wnt3a triggers the Wnt/Ca2+ signaling pathway, indicated by an increase of cytosolic free calcium ([Ca2+<..
  47. Cisternas P, Salazar P, Silva Alvarez C, Barros L, Inestrosa N. Activation of Wnt Signaling in Cortical Neurons Enhances Glucose Utilization through Glycolysis. J Biol Chem. 2016;291:25950-25964 pubmed
    ..In the present study, we found that acute treatment with the Wnt3a ligand induced a large increase in glucose uptake, without changes in the expression or localization of glucose ..
  48. Suzuki A, Ozono K, Kubota T, Kondou H, Tachikawa K, Michigami T. PTH/cAMP/PKA signaling facilitates canonical Wnt signaling via inactivation of glycogen synthase kinase-3beta in osteoblastic Saos-2 cells. J Cell Biochem. 2008;104:304-17 pubmed
    ..b>Wnt3a and forskolin synergistically increased the TCF-dependent transactivation...
  49. Zhu A, Shen L, Xu L, Chen W, Huang Y. Suppression of Wnt5a, but not Wnts, relieves chronic post-thoracotomy pain via anti-inflammatory modulation in rats. Biochem Biophys Res Commun. 2017;493:474-480 pubmed publisher
    ..We investigated whether Wnt3a and Wnt5a were involved in the development of CPTP, concerning their regulation of inflammatory responses in a ..
  50. Kelly J, Kleemann D, Rudiger S, Walker S. Effects of grade of oocyte-cumulus complex and the interactions between grades on the production of blastocysts in the cow, ewe and lamb. Reprod Domest Anim. 2007;42:577-82 pubmed
    ....
  51. Wang Y, Liao J, Tang S, Shu J, Zhang W. HIV-1 gp120 Upregulates Brain-Derived Neurotrophic Factor (BDNF) Expression in BV2 Cells via the Wnt/β-Catenin Signaling Pathway. J Mol Neurosci. 2017;62:199-208 pubmed publisher
    ..Furthermore, gp120-treated BV2 also accumulated Wnt3a and β-catenin, suggesting the activation of the Wnt/β-catenin pathway...
  52. Kang Y, Park H, Chung H, Min H, Park E, Lee M, et al. Wnt/β-catenin signaling mediates the antitumor activity of magnolol in colorectal cancer cells. Mol Pharmacol. 2012;82:168-77 pubmed publisher
    ..Magnolol also suppressed Wnt3a-induced β-catenin translocation and subsequent target gene expression in human embryonic kidney 293 cells...
  53. Yamamoto H, Sato A, Kikuchi A. Apical secretion of Wnt1 in polarized epithelial cells is regulated by exocyst-mediated trafficking. J Biochem. 2017;162:317-326 pubmed publisher
    ..secretion of Wnts in polarized epithelial cells is unique; Wnt11 is secreted apically, whereas Wnt5a and Wnt3a are secreted basolaterally...
  54. Serysheva E, Berhane H, Grumolato L, Demir K, Balmer S, Bodak M, et al. Wnk kinases are positive regulators of canonical Wnt/β-catenin signalling. EMBO Rep. 2013;14:718-25 pubmed publisher
    ..Importantly, knockdown of human WNK1 and WNK2 also results in decreased Wnt signalling in mammalian cell culture, suggesting that Wnk kinases have a conserved function in ensuring peak levels of canonical Wnt signalling. ..
  55. Takahashi Y, Sato S, Kurashima Y, Yamamoto T, Kurokawa S, Yuki Y, et al. A Refined Culture System for Human Induced Pluripotent Stem Cell-Derived Intestinal Epithelial Organoids. Stem Cell Reports. 2018;10:314-328 pubmed publisher
    ..2) We obtained intestinal organoids from human iPSCs more efficiently by supplementing WNT3A and fibroblast growth factor 2 to induce differentiation into definitive endoderm...
  56. Katoh M. Molecular cloning and expression of mouse Wnt14, and structural comparison between mouse Wnt14-Wnt3a gene cluster and human WNT14-WNT3A gene cluster. Int J Mol Med. 2002;9:221-7 pubmed
    Glycoprotein WNTs play key roles in carcinogenesis and embryogenesis. Human WNT14 and WNT3A genes are clustered in human chromosome 1q42 region with an interval of about 58 kb...
  57. Miyamoto K, Ohkawara B, Ito M, Masuda A, Hirakawa A, Sakai T, et al. Fluoxetine ameliorates cartilage degradation in osteoarthritis by inhibiting Wnt/β-catenin signaling. PLoS ONE. 2017;12:e0184388 pubmed publisher
    ..Fluoxetine inhibited both Wnt3A- and LiCl-induced loss of proteoglycans in chondrogenically differentiated ATDC5 cells...
  58. Bourhis E, Tam C, Franke Y, Bazan J, Ernst J, Hwang J, et al. Reconstitution of a frizzled8.Wnt3a.LRP6 signaling complex reveals multiple Wnt and Dkk1 binding sites on LRP6. J Biol Chem. 2010;285:9172-9 pubmed publisher
    ..b>Wnt3a.LRP6 signaling complex...
  59. Chuang C, Lin K, Hsiao M, Stone L, Chen H, Huang Y, et al. Meiotic competent human germ cell-like cells derived from human embryonic stem cells induced by BMP4/WNT3A signaling and OCT4/EpCAM (epithelial cell adhesion molecule) selection. J Biol Chem. 2012;287:14389-401 pubmed publisher
    ..the percentage of OCT4(+)/EpCAM(+) cells as readout, we demonstrated the synergistic effect of BMP4/pSMAD1/5/8 and WNT3A/β-CATENIN in promoting hESCs toward the germline fate...
  60. Krishnamoorthy A, Witkowski A, Tran J, Weers P, Ryan R. Characterization of secondary structure and lipid binding behavior of N-terminal saposin like subdomain of human Wnt3a. Arch Biochem Biophys. 2017;630:38-46 pubmed publisher
    ..To investigate the function of the Wnt3a saposin-like subdomain (SLD), recombinant SLD was studied in isolation...
  61. Cheng R, Ding L, He X, Takahashi Y, Ma J. Interaction of PPARα With the Canonic Wnt Pathway in the Regulation of Renal Fibrosis. Diabetes. 2016;65:3730-3743 pubmed
    ..of PPARα both attenuated the expression of fibrotic factors, and suppressed high glucose-induced or Wnt3a-induced Wnt signaling in renal cells. Fenofibrate inhibited Wnt signaling in the kidney of diabetic rats...
  62. Yu J, Chia J, Canning C, Jones C, Bard F, Virshup D. WLS retrograde transport to the endoplasmic reticulum during Wnt secretion. Dev Cell. 2014;29:277-91 pubmed publisher
    ..ERGIC2 is required for efficient Wnt secretion. ER retrieval is an integral part of the WLS transport cycle. ..