VEGF

Summary

Gene Symbol: VEGF
Description: vascular endothelial growth factor A
Alias: MVCD1, VEGF, VPF, vascular endothelial growth factor A, vascular endothelial growth factor A121, vascular endothelial growth factor A165, vascular permeability factor
Species: human
Products:     VEGF

Top Publications

  1. Menendez D, Krysiak O, Inga A, Krysiak B, Resnick M, Schönfelder G. A SNP in the flt-1 promoter integrates the VEGF system into the p53 transcriptional network. Proc Natl Acad Sci U S A. 2006;103:1406-11 pubmed
    The VEGF system is essential for angiogenesis. VEGF overexpression frequently correlates with increased microvascularity and metastasis and decreased spontaneous apoptosis...
  2. Holmes D, Zachary I. Vascular endothelial growth factor regulates stanniocalcin-1 expression via neuropilin-1-dependent regulation of KDR and synergism with fibroblast growth factor-2. Cell Signal. 2008;20:569-79 pubmed publisher
    ..the mammalian homolog in numerous gene profiling studies of angiogenesis and vascular endothelial growth factor-A (VEGF-A(165))-regulated gene expression, suggests that regulation of this factor may be a key feature of the angiogenic ..
  3. Gerhardt H, Golding M, Fruttiger M, Ruhrberg C, Lundkvist A, Abramsson A, et al. VEGF guides angiogenic sprouting utilizing endothelial tip cell filopodia. J Cell Biol. 2003;161:1163-77 pubmed
    Vascular endothelial growth factor (VEGF-A) is a major regulator of blood vessel formation and function...
  4. Gehrke I, Gandhirajan R, Poll Wolbeck S, Hallek M, Kreuzer K. Bone marrow stromal cell-derived vascular endothelial growth factor (VEGF) rather than chronic lymphocytic leukemia (CLL) cell-derived VEGF is essential for the apoptotic resistance of cultured CLL cells. Mol Med. 2011;17:619-27 pubmed publisher
    ..The vascular endothelial growth factor (VEGF) possesses a role in this apoptotic block, although underlying functional mechanisms and the involvement of the ..
  5. Bills V, Varet J, Millar A, Harper S, Soothill P, Bates D. Failure to up-regulate VEGF165b in maternal plasma is a first trimester predictive marker for pre-eclampsia. Clin Sci (Lond). 2009;116:265-72 pubmed publisher
    ..b>VEGF(165)b, formed by alternative splicing of VEGF (vascular endothelial growth factor) pre-mRNA, inhibits VEGF(165)-..
  6. Ambati B, Nozaki M, Singh N, Takeda A, Jani P, Suthar T, et al. Corneal avascularity is due to soluble VEGF receptor-1. Nature. 2006;443:993-7 pubmed
    ..obscure and are all the more remarkable given the presence in the cornea of vascular endothelial growth factor (VEGF)-A, a potent stimulator of angiogenesis, and the proximity of the cornea to vascularized tissues...
  7. Chen H, Li L, Wang S, Lei Y, Ge Q, Lv N, et al. Reduced miR-126 expression facilitates angiogenesis of gastric cancer through its regulation on VEGF-A. Oncotarget. 2014;5:11873-85 pubmed
    ..of miR-126 was found to inversely correlate with an increased microvessel density (MVD) and vascular endothelial growth factor A (VEGF-A) expression in gastric cancer tissues...
  8. Alioglu E, Turk U, Cam S, Abbasaliyev A, Tengiz I, Ercan E. Polymorphisms of the methylenetetrahydrofolate reductase, vascular endothelial growth factor, endothelial nitric oxide synthase, monocyte chemoattractant protein-1 and apolipoprotein E genes are not associated with carotid intima-media thickness. Can J Cardiol. 2009;25:e1-5 pubmed
    ..polymorphisms in the 5,10-methylenetetrahydrofolate reductase (MTHFR), vascular endothelial growth factor (VEGF), endothelial nitric oxide synthase (eNOS), monocyte chemoattractant protein-1 (MCP-1) and apolipoprotein E (ApoE) ..
  9. Zhou Y, Hu W, Zhuang W, Liu G, Wu T, Yao X, et al. Vascular endothelial growth factor (VEGF) +936 C/T gene polymorphisms and gastric cancer risk: a meta-analysis involving 4,138 subjects. Int J Biol Markers. 2010;25:213-8 pubmed
    The association between vascular endothelial growth factor (VEGF) +936 C/T gene polymorphisms and gastric cancer risk is still controversial and ambiguous. The objective of our study was to investigate this association...

More Information

Publications528 found, 100 shown here

  1. Xu D, Fuster M, Lawrence R, Esko J. Heparan sulfate regulates VEGF165- and VEGF121-mediated vascular hyperpermeability. J Biol Chem. 2011;286:737-45 pubmed publisher
    VEGF was first described as vascular permeability factor, a potent inducer of vascular leakage...
  2. Lanahan A, Zhang X, Fantin A, Zhuang Z, Rivera Molina F, Speichinger K, et al. The neuropilin 1 cytoplasmic domain is required for VEGF-A-dependent arteriogenesis. Dev Cell. 2013;25:156-68 pubmed publisher
    Neuropilin 1 (NRP1) plays an important but ill-defined role in VEGF-A signaling and vascular morphogenesis...
  3. Esposito F, Mathieu Costello O, Entin P, Wagner P, Richardson R. The skeletal muscle VEGF mRNA response to acute exercise in patients with chronic heart failure. Growth Factors. 2010;28:139-47 pubmed publisher
    ..CHF) and six controls, we examined (a) resting and post-exercise muscle vascular endothelial growth factor (VEGF) mRNA levels and (b) their relationship with muscle structure and function...
  4. Jain L, Vargo C, Danesi R, Sissung T, Price D, Venzon D, et al. The role of vascular endothelial growth factor SNPs as predictive and prognostic markers for major solid tumors. Mol Cancer Ther. 2009;8:2496-508 pubmed publisher
    Angiogenesis is crucial for development and metastasis of tumors, and vascular endothelial growth factor (VEGF) is a key mediator of this process...
  5. Heid I, Jackson A, Randall J, Winkler T, Qi L, Steinthorsdottir V, et al. Meta-analysis identifies 13 new loci associated with waist-hip ratio and reveals sexual dimorphism in the genetic basis of fat distribution. Nat Genet. 2010;42:949-60 pubmed publisher
    ..9 × 10⁻³ to P = 1.2 × 10⁻¹³). These findings provide evidence for multiple loci that modulate body fat distribution independent of overall adiposity and reveal strong gene-by-sex interactions. ..
  6. Nakanishi K, Watanabe C. Single nucleotide polymorphisms of vascular endothelial growth factor gene intron 2 are markers for early progression of diabetic retinopathy in Japanese with type 1 diabetes. Clin Chim Acta. 2009;402:171-5 pubmed
    Few studies investigated the relationship between single nucleotide polymorphisms (SNPs) of vascular endothelial growth factor (VEGF) gene and time to the development and progression of diabetic retinopathy.
  7. Lieb W, Safa R, Benjamin E, Xanthakis V, Yin X, Sullivan L, et al. Vascular endothelial growth factor, its soluble receptor, and hepatocyte growth factor: clinical and genetic correlates and association with vascular function. Eur Heart J. 2009;30:1121-7 pubmed publisher
    ..We evaluated clinical and genetic correlates of circulating vascular endothelial growth factor A (VEGF), its soluble receptor sFlt-1, and hepatocyte growth factor (HGF) in 3754 Framingham Study ..
  8. Hamzaoui K, Ayed K, Hamza M, Hamzaoui A. VEGF and mRNA VEGF expression in CSF from Behçet's disease with neurological involvement. J Neuroimmunol. 2009;213:148-53 pubmed publisher
    Vascular endothelial growth factor (VEGF) stimulates angiogenesis, but is also pro-inflammatory and plays an important role in the development of neurological disease, where it can have both attenuating and exacerbating effects...
  9. Nakasaki T, Wada H, Shigemori C, Miki C, Gabazza E, Nobori T, et al. Expression of tissue factor and vascular endothelial growth factor is associated with angiogenesis in colorectal cancer. Am J Hematol. 2002;69:247-54 pubmed
    We examined the expression of tissue factor (TF) and vascular endothelial growth factor (VEGF) and the microvessel density (MVD) in 100 patients with colorectal cancer, and we investigated the relationship of the expression of TF or VEGF ..
  10. Jantus Lewintre E, Sanmartín E, Sirera R, Blasco A, Sanchez J, Taron M, et al. Combined VEGF-A and VEGFR-2 concentrations in plasma: diagnostic and prognostic implications in patients with advanced NSCLC. Lung Cancer. 2011;74:326-31 pubmed publisher
    The vascular endothelial growth factor (VEGF) family of ligands and receptors (VEGFR) play an important role in tumor angiogenesis. Increased expression of angiogenic factors in tumors or in blood is associated with poor prognosis...
  11. Zhong C, Wei W, Su X, Li H, Xu F, Guo R. Serum and tissue vascular endothelial growth factor predicts prognosis in hepatocellular carcinoma patients after partial liver resection. Hepatogastroenterology. 2012;59:93-7 pubmed publisher
    To explore the effect of vascular endothelial growth factor (VEGF) expression on prognosis of hepatocellular carcinoma (HCC) after partial liver resection...
  12. Usui T, Murai T, Tanaka T, Yamaguchi K, Nagakubo D, Lee C, et al. Characterization of mac25/angiomodulin expression by high endothelial venule cells in lymphoid tissues and its identification as an inducible marker for activated endothelial cells. Int Immunol. 2002;14:1273-82 pubmed
  13. Wang Y, Zheng Y, Zhang W, Yu H, Lou K, Zhang Y, et al. Polymorphisms of KDR gene are associated with coronary heart disease. J Am Coll Cardiol. 2007;50:760-7 pubmed
    ..Vascular endothelial growth factor (VEGF) and its receptor KDR (kinase insert domain-containing receptor/fetal liver kinase-1, also called VEGFR2) play ..
  14. Bento C, Fernandes R, Matafome P, Sena C, Seica R, Pereira P. Methylglyoxal-induced imbalance in the ratio of vascular endothelial growth factor to angiopoietin 2 secreted by retinal pigment epithelial cells leads to endothelial dysfunction. Exp Physiol. 2010;95:955-70 pubmed publisher
    ..In this study, we hypothesize that increased levels of MGO disrupt the ratio of vascular endothelial growth factor (VEGF) to angiopoietin 2 (Ang 2) secreted by retinal pigment epithelial (RPE) cells, which provides a key destabilizing ..
  15. Muller Y, Li B, Christinger H, Wells J, Cunningham B, de Vos A. Vascular endothelial growth factor: crystal structure and functional mapping of the kinase domain receptor binding site. Proc Natl Acad Sci U S A. 1997;94:7192-7 pubmed
    Vascular endothelial growth factor (VEGF) is a homodimeric member of the cystine knot family of growth factors, with limited sequence homology to platelet-derived growth factor (PDGF) and transforming growth factor beta2 (TGF-beta)...
  16. Viita H, Markkanen J, Eriksson E, Nurminen M, Kinnunen K, Babu M, et al. 15-lipoxygenase-1 prevents vascular endothelial growth factor A- and placental growth factor-induced angiogenic effects in rabbit skeletal muscles via reduction in growth factor mRNA levels, NO bioactivity, and downregulation of VEGF receptor 2 expre. Circ Res. 2008;102:177-84 pubmed
    ..We used adenovirus-mediated gene transfers to study the effects of 15-LO-1 on vascular endothelial growth factor (VEGF)-A165- and placental growth factor (PlGF)-induced angiogenesis in rabbit skeletal muscles...
  17. Barr M, Bouchier Hayes D, Harmey J. Vascular endothelial growth factor is an autocrine survival factor for breast tumour cells under hypoxia. Int J Oncol. 2008;32:41-8 pubmed
    Vascular endothelial growth factor (VEGF) is produced by most tumour types and stimulates the growth of new blood vessels in the tumour...
  18. Francis P, Hamon S, Ott J, Weleber R, Klein M. Polymorphisms in C2, CFB and C3 are associated with progression to advanced age related macular degeneration associated with visual loss. J Med Genet. 2009;46:300-7 pubmed publisher
    ..Five genes have now been shown to be independently involved in progression from intermediate disease (before vision loss has occurred) to advanced disease in which blindness is frequent. ..
  19. Kawai H, Li H, Chun P, Avraham S, Avraham H. Direct interaction between BRCA1 and the estrogen receptor regulates vascular endothelial growth factor (VEGF) transcription and secretion in breast cancer cells. Oncogene. 2002;21:7730-9 pubmed
    ..Here, we show that BRCA1 and the estrogen receptor alpha (ER-alpha) modulated vascular endothelial growth factor (VEGF) gene transcription and secretion in breast cancer cells...
  20. Roybal C, Yang S, Sun C, Hurtado D, Vander Jagt D, Townes T, et al. Homocysteine increases the expression of vascular endothelial growth factor by a mechanism involving endoplasmic reticulum stress and transcription factor ATF4. J Biol Chem. 2004;279:14844-52 pubmed
    Vascular endothelial growth factor (VEGF) plays a key role in the development and progression of diabetic retinopathy...
  21. van der Flier M, van Leeuwen H, van Kessel K, Kimpen J, Hoepelman A, Geelen S. Plasma vascular endothelial growth factor in severe sepsis. Shock. 2005;23:35-8 pubmed
    Vascular endothelial growth factor (VEGF) is a potent vascular permeability factor. The development of capillary leak is common in septic patients, and several sepsis-associated mediators may induce VEGF production...
  22. Viikki M, Anttila S, Kampman O, Illi A, Huuhka M, Setälä Soikkeli E, et al. Vascular endothelial growth factor (VEGF) polymorphism is associated with treatment resistant depression. Neurosci Lett. 2010;477:105-8 pubmed publisher
    ..of trophic factors, including brain-derived neurotrophic factor (BDNF) and vascular endothelial growth factor (VEGF)...
  23. Storkebaum E, Lambrechts D, Carmeliet P. VEGF: once regarded as a specific angiogenic factor, now implicated in neuroprotection. Bioessays. 2004;26:943-54 pubmed
    Both blood vessels and nerves are guided to their target. Vascular endothelial growth factor (VEGF)A is a key signal in the induction of vessel growth (a process termed angiogenesis)...
  24. Petrovic M, Korosec P, Kosnik M, Osredkar J, Hawlina M, Peterlin B, et al. Local and genetic determinants of vascular endothelial growth factor expression in advanced proliferative diabetic retinopathy. Mol Vis. 2008;14:1382-7 pubmed
    ..Vascular endothelial growth factor (VEGF) appears to play a central role in mediating microvascular pathology in PDR...
  25. Hansen T, Garm Spindler K, Andersen R, Lindebjerg J, Brandslund I, Jakobsen A. The predictive value of genetic variations in the vascular endothelial growth factor A gene in metastatic colorectal cancer. Pharmacogenomics J. 2011;11:53-60 pubmed publisher
    Single-nucleotide polymorphisms (SNPs) in the vascular endothelial growth factor A (VEGF-A) gene may have clinical implications...
  26. Sun S, Huang D, Cao C, Deng Z. Polymorphism of VEGF-460C/T associated with the risk and clinical characteristics of lung cancer in Chinese population. Med Oncol. 2013;30:410 pubmed publisher
    Vascular endothelial growth factor (VEGF) is a major regulator of angiogenesis in the process of tumor growth and metastasis...
  27. Bates D, Cui T, Doughty J, Winkler M, Sugiono M, Shields J, et al. VEGF165b, an inhibitory splice variant of vascular endothelial growth factor, is down-regulated in renal cell carcinoma. Cancer Res. 2002;62:4123-31 pubmed
    Angiogenesis is essential for tumor growth. Vascular endothelial growth factor (VEGF) is the most potent growth factor of tumor neovasculature, has been shown to be up-regulated in every tumor studied thus far, and is correlated with ..
  28. Ribatti D. The crucial role of vascular permeability factor/vascular endothelial growth factor in angiogenesis: a historical review. Br J Haematol. 2005;128:303-9 pubmed
    ..of one of the best characterized angiogenic factors, namely vascular endothelial growth factor (VEGF)/vascular permeability factor. Moreover, different strategies, designed to stimulate and to inhibit VEGF production in the context of ..
  29. Shimoyamada H, Yazawa T, Sato H, Okudela K, Ishii J, Sakaeda M, et al. Early growth response-1 induces and enhances vascular endothelial growth factor-A expression in lung cancer cells. Am J Pathol. 2010;177:70-83 pubmed publisher
    Vascular endothelial growth factor-A (VEGF-A) is crucial for angiogenesis, vascular permeability, and metastasis during tumor development...
  30. Andersen S, Donnem T, Al Shibli K, Al Saad S, Stenvold H, Busund L, et al. Prognostic impacts of angiopoietins in NSCLC tumor cells and stroma: VEGF-A impact is strongly associated with Ang-2. PLoS ONE. 2011;6:e19773 pubmed publisher
    Angiopoietins and their receptor Tie-2 are, in concert with VEGF-A, key mediators in angiogenesis...
  31. Kashyap V, Ahmad S, Nilsson E, Helczynski L, Kenna S, Persson J, et al. The lysine specific demethylase-1 (LSD1/KDM1A) regulates VEGF-A expression in prostate cancer. Mol Oncol. 2013;7:555-66 pubmed publisher
    ..We correlated LSD1 and JMJD2A expression with known mediators of prostate cancer progression: VEGF-A and cyclin A1...
  32. Tang D, Nagano H, Yamamoto H, Wada H, Nakamura M, Kondo M, et al. Angiogenesis in cholangiocellular carcinoma: expression of vascular endothelial growth factor, angiopoietin-1/2, thrombospondin-1 and clinicopathological significance. Oncol Rep. 2006;15:525-32 pubmed
    ..Tumor angiogenesis was assessed by microvessel density (MVD) using the anti-CD34 antibody, and the expression of VEGF, Ang-1, Ang-2, and TSP-1 was determined by immunohistochemistry. The mean (+/- SD) MVD was 87.2+/-52...
  33. Errera F, Canani L, Silva M, Yeh E, Takahashi W, Santos K, et al. Functional vascular endothelial growth factor -634G>C SNP is associated with proliferative diabetic retinopathy: a case-control study in a Brazilian population of European ancestry. Diabetes Care. 2007;30:275-9 pubmed
    ..nucleotide polymorphism (SNP) -634G>C at the 5' regulatory region of the vascular endothelial growth factor (VEGF) in the risk of proliferative diabetic retinopathy (PDR) in the Brazilian population of European ancestry with type ..
  34. Evensen L, Micklem D, Blois A, Berge S, Aarsaether N, Littlewood Evans A, et al. Mural cell associated VEGF is required for organotypic vessel formation. PLoS ONE. 2009;4:e5798 pubmed publisher
    ..This phenotypic sequence required endothelial-mural cell-cell contact, mural cell-derived VEGF and endothelial VEGFR2 signaling...
  35. Vacca A, Ria R, Ribatti D, Semeraro F, Djonov V, Di Raimondo F, et al. A paracrine loop in the vascular endothelial growth factor pathway triggers tumor angiogenesis and growth in multiple myeloma. Haematologica. 2003;88:176-85 pubmed
    In tumors, vascular endothelial growth factor-A (VEGF-A) stimulates angiogenesis and vascular permeability by activating the tyrosine kinase receptor-2 (VEGFR-2 or KDR/Flk-1) and-1 (VEGFR-1 or Flt-1)...
  36. Huang S, Wu M, Shun C, Wang H, Lin M, Kuo M, et al. Interleukin-6 increases vascular endothelial growth factor and angiogenesis in gastric carcinoma. J Biomed Sci. 2004;11:517-27 pubmed
    ..Vascular endothelial growth factor (VEGF) is a potent tumor angiogenic factor in GC...
  37. Zhai R, Gong M, Zhou W, Thompson T, Kraft P, Su L, et al. Genotypes and haplotypes of the VEGF gene are associated with higher mortality and lower VEGF plasma levels in patients with ARDS. Thorax. 2007;62:718-22 pubmed
    ..Vascular endothelial growth factor (VEGF) plays a critical role in endothelial destruction and angiogenesis...
  38. Sharma S, Murphy A, Soto Quiros M, Avila L, Klanderman B, Sylvia J, et al. Association of VEGF polymorphisms with childhood asthma, lung function and airway responsiveness. Eur Respir J. 2009;33:1287-94 pubmed publisher
    Vascular endothelial growth factor (VEGF) is an angiogenic factor implicated in asthma severity...
  39. Mohle R, Green D, Moore M, Nachman R, Rafii S. Constitutive production and thrombin-induced release of vascular endothelial growth factor by human megakaryocytes and platelets. Proc Natl Acad Sci U S A. 1997;94:663-8 pubmed
    ..for secretion of cytokines, we evaluated megakaryocytic cells for secretion of vascular endothelial growth factor (VEGF)...
  40. Wei L, Kuo M, Chen C, Chou C, Lai K, Lee C, et al. Interleukin-6 promotes cervical tumor growth by VEGF-dependent angiogenesis via a STAT3 pathway. Oncogene. 2003;22:1517-27 pubmed
    ..cancer cells, an effect that is specifically associated with upregulation of vascular endothelial growth factor (VEGF)...
  41. Kim S, Choi Y, Choung S, Jun J, Kim J, Moon S. Vascular endothelial growth factor gene +405 C/G polymorphism is associated with susceptibility to advanced stage endometriosis. Hum Reprod. 2005;20:2904-8 pubmed
    Vascular endothelial growth factor (VEGF) is known to play a pivotal role in the development of endometriosis...
  42. Slomiany M, Black L, Kibbey M, Day T, Rosenzweig S. IGF-1 induced vascular endothelial growth factor secretion in head and neck squamous cell carcinoma. Biochem Biophys Res Commun. 2006;342:851-8 pubmed
    Elevated vascular endothelial growth factor (VEGF) levels correlate with increased progression and poor prognosis of head and neck squamous cell carcinomas (HNSCC)...
  43. Xu H, Czerwinski P, Hortmann M, Sohn H, Förstermann U, Li H. Protein kinase C alpha promotes angiogenic activity of human endothelial cells via induction of vascular endothelial growth factor. Cardiovasc Res. 2008;78:349-55 pubmed
    ..mRNA expression of vascular endothelial growth factor (VEGF) was analysed by quantitative real-time RT-PCR in human umbilical vein endothelial cells (HUVEC) and HUVEC-derived ..
  44. Kim E, Jeong P, Quan C, Kim J, Bae S, Yoon S, et al. Genotypes of TNF-alpha, VEGF, hOGG1, GSTM1, and GSTT1: useful determinants for clinical outcome of bladder cancer. Urology. 2005;65:70-5 pubmed
    To determine whether polymorphisms of tumor necrosis factor-alpha (TNF-alpha), vascular endothelial growth factor (VEGF), human 8-oxoguanine DNA glycosylase 1 (hOGG1), glutathione S-transferase-mu (GSTM1), and glutathione S-transferase-..
  45. Kataoka N, Cai Q, Wen W, Shu X, Jin F, Gao Y, et al. Population-based case-control study of VEGF gene polymorphisms and breast cancer risk among Chinese women. Cancer Epidemiol Biomarkers Prev. 2006;15:1148-52 pubmed
    Vascular endothelial growth factor (VEGF) is a major angiogenic factor involved in a number of pathologic processes, including neovascularization, a crucial step in the development of solid malignancies...
  46. Lin C, Wu H, Tsai F, Chen H, Chen W. Vascular endothelial growth factor gene-460 C/T polymorphism is a biomarker for prostate cancer. Urology. 2003;62:374-7 pubmed
    ..of prostate cancer is presumed to be associated with a polymorphism of the vascular endothelial growth factor (VEGF) gene...
  47. Takekoshi K, Isobe K, Yashiro T, Hara H, Ishii K, Kawakami Y, et al. Expression of vascular endothelial growth factor (VEGF) and its cognate receptors in human pheochromocytomas. Life Sci. 2004;74:863-71 pubmed
    ..As vascular endothelial growth factor (VEGF) is a potent mitogen for vascular endothelial cells, here we have investigated the mRNA and protein expression of ..
  48. Pore N, Liu S, Shu H, Li B, Haas Kogan D, Stokoe D, et al. Sp1 is involved in Akt-mediated induction of VEGF expression through an HIF-1-independent mechanism. Mol Biol Cell. 2004;15:4841-53 pubmed
    Increased expression of vascular endothelial growth factor (VEGF) contributes to the growth of many tumors by increasing angiogenesis...
  49. Tarnowski B, Chudecka Głaz A, Gorski B, Rzepka Gorska I. Vascular endothelial growth factor (VEGF) levels and mutation of the BRCA1 gene in breast cancer patients. Breast Cancer Res Treat. 2004;88:287-8 pubmed
    The aim of the study was to compare VEGF serum levels in breast cancer patients with and without BRCA1 gene mutation. We enrolled 80 patients, 22 premenopausal and 58 postmenopausal...
  50. Ito T, Ishii G, Saito S, Yano K, Hoshino A, Suzuki T, et al. Degradation of soluble VEGF receptor-1 by MMP-7 allows VEGF access to endothelial cells. Blood. 2009;113:2363-9 pubmed publisher
    Vascular endothelial growth factor (VEGF) signaling in endothelial cells serves a critical role in physiologic and pathologic angiogenesis...
  51. Yan H, Cui J, Yu J, Han J, Chen S, Zhang J, et al. [The expression of vascular endothelial growth factor of vitreous in patients with proliferative diabetic retinopathy]. Zhonghua Yan Ke Za Zhi. 2009;45:206-9 pubmed
    ..The vitreous fluid samples were obtained during surgery. The VEGF level in vitreous fluid was determined by enzyme linked immunosorbent assay, and the expression of vascular ..
  52. Mori T, Sawada M, Kuroboshi H, Tatsumi H, Katsuyama M, Iwasaku K, et al. Estrogen-related receptor ? expression and function are associated with vascular endothelial growth factor in human cervical cancer. Int J Gynecol Cancer. 2011;21:609-15 pubmed publisher
    ..Recently, it has been suggested that vascular endothelial growth factor (VEGF) could be one of the transcriptional targets of ERR? in breast cancer...
  53. Sivaprasad S, Govardhan B, Harithakrishna R, Venkat Rao G, Pradeep R, Kunal B, et al. Association of vascular endothelial growth factor (VEGF) gene polymorphism and increased serum VEGF concentration with pancreatic adenocarcinoma. Pancreatology. 2013;13:267-72 pubmed publisher
    BACKGROUND &AIM: Pancreatic cancer is related to high mortality rate. The vascular endothelial growth factor (VEGF) has a strong influence in tumor-related angiogenesis having association with the grade of angiogenesis and the ..
  54. Szeto C, Chow K, Poon P, Szeto C, Wong T, Li P. Genetic polymorphism of VEGF: Impact on longitudinal change of peritoneal transport and survival of peritoneal dialysis patients. Kidney Int. 2004;65:1947-55 pubmed
    Vascular endothelial growth factor (VEGF) plays a pivotal role in the peritoneal angiogenesis and hyperpermeability in patients on peritoneal dialysis...
  55. Farahani M, Treweeke A, Toh C, Till K, Harris R, Cawley J, et al. Autocrine VEGF mediates the antiapoptotic effect of CD154 on CLL cells. Leukemia. 2005;19:524-30 pubmed
    CD154 is an important regulator of chronic lymphocytic leukaemia (CLL)-cell survival. In CLL, high serum levels of VEGF are a feature of advanced disease, and we and others have previously shown that CLL cells produce and secrete this ..
  56. Awata T, Inoue K, Kurihara S, Ohkubo T, Watanabe M, Inukai K, et al. A common polymorphism in the 5'-untranslated region of the VEGF gene is associated with diabetic retinopathy in type 2 diabetes. Diabetes. 2002;51:1635-9 pubmed
    Vascular endothelial growth factor (VEGF), a major mediator of vascular permeability and angiogenesis, may play a pivotal role in mediating the development and progression of diabetic retinopathy...
  57. Boekhoorn S, Isaacs A, Uitterlinden A, van Duijn C, Hofman A, De Jong P, et al. Polymorphisms in the vascular endothelial growth factor gene and risk of age-related macular degeneration: the Rotterdam Study. Ophthalmology. 2008;115:1899-903 pubmed publisher
    Vascular endothelial growth factor (VEGF) is an important regulator of angiogenesis and a target for inhibition therapy in wet age-related macular degeneration (AMD)...
  58. Inoki I, Shiomi T, Hashimoto G, Enomoto H, Nakamura H, Makino K, et al. Connective tissue growth factor binds vascular endothelial growth factor (VEGF) and inhibits VEGF-induced angiogenesis. FASEB J. 2002;16:219-21 pubmed
    Vascular endothelial growth factor (VEGF) is a strong angiogenic mitogen and plays important roles in angiogenesis under various pathophysiological conditions...
  59. Dabrosin C. Variability of vascular endothelial growth factor in normal human breast tissue in vivo during the menstrual cycle. J Clin Endocrinol Metab. 2003;88:2695-8 pubmed
    ..Vascular endothelial growth factor (VEGF) has a key stimulatory role in angiogenesis...
  60. Ancelin M, Buteau Lozano H, Meduri G, Osborne Pellegrin M, Sordello S, Plouet J, et al. A dynamic shift of VEGF isoforms with a transient and selective progesterone-induced expression of VEGF189 regulates angiogenesis and vascular permeability in human uterus. Proc Natl Acad Sci U S A. 2002;99:6023-8 pubmed
    ..e., development of spiral arteries). Vascular endothelial growth factor (VEGF) is associated with angiogenesis and capillary permeability in this tissue...
  61. Ray D, Mishra M, Ralph S, Read I, Davies R, Brenchley P. Association of the VEGF gene with proliferative diabetic retinopathy but not proteinuria in diabetes. Diabetes. 2004;53:861-4 pubmed
    ..Vascular endothelial growth factor (VEGF) is a potent angiogenic and vascular permeability factor and is implicated in both of these diabetes complications...
  62. Scapini P, Morini M, Tecchio C, Minghelli S, Di Carlo E, Tanghetti E, et al. CXCL1/macrophage inflammatory protein-2-induced angiogenesis in vivo is mediated by neutrophil-derived vascular endothelial growth factor-A. J Immunol. 2004;172:5034-40 pubmed
    ..an angiogenic response to CXCL1/MIP-2, although they respond normally to vascular endothelial growth factor-A (VEGF-A)...
  63. Punyadeera C, Thijssen V, Tchaikovski S, Kamps R, Delvoux B, Dunselman G, et al. Expression and regulation of vascular endothelial growth factor ligands and receptors during menstruation and post-menstrual repair of human endometrium. Mol Hum Reprod. 2006;12:367-75 pubmed
    ..We analysed the mRNA expression levels of all known vascular endothelial growth factor (VEGF) ligands and receptors in human endometrium collected in the menstrual and proliferative phases of the menstrual ..
  64. Mohammed R, Green A, El Shikh S, Paish E, Ellis I, Martin S. Prognostic significance of vascular endothelial cell growth factors -A, -C and -D in breast cancer and their relationship with angio- and lymphangiogenesis. Br J Cancer. 2007;96:1092-100 pubmed
    Vascular endothelial cell growth factors (VEGF)-A, -C and -D have potent angio and lymphangiogenic functions in experimental models, although their role in the progression of human breast cancer is unclear...
  65. Karaa Z, Iacovoni J, Bastide A, Lacazette E, Touriol C, Prats H. The VEGF IRESes are differentially susceptible to translation inhibition by miR-16. RNA. 2009;15:249-54 pubmed publisher
    ..In this report, we first validate the targeting of miR-16 to a predicted binding site in the VEGF 3'UTR...
  66. Tahara T, Shibata T, Nakamura M, Yamashita H, Yoshioka D, Hirata I, et al. Effect of polymorphisms in the 3' untranslated region (3'-UTR) of vascular endothelial growth factor gene on gastric cancer and peptic ulcer diseases in Japan. Mol Carcinog. 2009;48:1030-7 pubmed publisher
    ..We investigated the effect of vascular endothelial growth factor (VEGF) gene polymorphisms on the risk of gastric cancer (GC) and peptic ulcer diseases in a Japanese population...
  67. Goel H, Mercurio A. VEGF targets the tumour cell. Nat Rev Cancer. 2013;13:871-82 pubmed publisher
    The function of vascular endothelial growth factor (VEGF) in cancer is not limited to angiogenesis and vascular permeability...
  68. Kwinta P, Bik Multanowski M, Mitkowska Z, Tomasik T, Legutko M, Pietrzyk J. Genetic risk factors of bronchopulmonary dysplasia. Pediatr Res. 2008;64:682-8 pubmed publisher
    ..between bronchopulmonary dysplasia (BPD) and polymorphisms of genes coding for vascular endothelial growth factor (VEGF), transforming growth factor (TGF-[beta]1), insulin-like growth factor (IGF-1), and 5,10-methylenetetrahydrofolate ..
  69. Masago K, Fujita S, Kim Y, Hatachi Y, Fukuhara A, Nagai H, et al. Effect of vascular endothelial growth factor polymorphisms on survival in advanced-stage non-small-cell lung cancer. Cancer Sci. 2009;100:1917-22 pubmed publisher
    Polymorphisms have been identified in the vascular endothelial growth factor (VEGF) gene that may affect VEGF production...
  70. Schweighofer B, Testori J, Sturtzel C, Sattler S, Mayer H, Wagner O, et al. The VEGF-induced transcriptional response comprises gene clusters at the crossroad of angiogenesis and inflammation. Thromb Haemost. 2009;102:544-54 pubmed publisher
    b>VEGF-A is the major trigger of vasculogenesis and physiologic angiogenesis...
  71. Feghhi M, Nikzamir A, Esteghamati A, Mahmoudi T, Yekaninejad M. Relationship of vascular endothelial growth factor (VEGF) +405 G/C polymorphism and proliferative retinopathy in patients with type 2 diabetes. Transl Res. 2011;158:85-91 pubmed publisher
    The role of the vascular endothelial growth factor (VEGF) gene polymorphism in proliferative diabetic retinopathy (PDR) is controversial...
  72. Zhou L, Luan H, Dong X, Jin G, Man D, Shang H. Vascular endothelial growth factor gene polymorphisms and colorectal cancer risk: a meta-analysis. Genet Mol Res. 2011;10:3674-88 pubmed publisher
    Vascular endothelial growth factor (VEGF) is an endothelial cell-specific mitogen involved in a number of pathologic processes, including angiogenesis, tumor growth and metastasis...
  73. Ku K, Wan L, Peng H, Tsai M, Tsai C, Tsai F. Vascular endothelial growth factor gene-460 C/T polymorphism is a biomarker for oral cancer. Oral Oncol. 2005;41:497-502 pubmed
    ..or progression of oral cancer may be associated with a polymorphism of the vascular endothelial growth factor (VEGF) gene...
  74. Coulam C, Jeyendran R. Vascular endothelial growth factor gene polymorphisms and recurrent pregnancy loss. Am J Reprod Immunol. 2008;59:301-5 pubmed publisher
    ..successful, pregnancy must induce its own blood supply through angiogenesis and vascular endothelial growth factor (VEGF) is the best characterized regulator of angiogenesis and one polymorphism of the VEGF gene, -1154, has been ..
  75. Liu Q, Li Y, Zhao J, Zhou R, Wang N, Sun D, et al. [Association of single nucleotide polymorphisms in VEGF gene with the risk of endometriosis and adenomyosis]. Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2009;26:165-9 pubmed publisher
    To investigate the association of single nucleotide polymorphisms (SNPs) in VEGF gene with the risk of endometriosis and adenomyosis...
  76. Capp C, Wajner S, Siqueira D, Brasil B, Meurer L, Maia A. Increased expression of vascular endothelial growth factor and its receptors, VEGFR-1 and VEGFR-2, in medullary thyroid carcinoma. Thyroid. 2010;20:863-71 pubmed publisher
    Vascular endothelial growth factor (VEGF-A) expression is upregulated in the majority of human tumors, where it stimulates proliferation, migration, and survival of endothelial cells...
  77. Fiorelli A, Vicidomini G, Di Domenico M, Napolitano F, Messina G, Morgillo F, et al. Vascular endothelial growth factor in pleural fluid for differential diagnosis of benign and malignant origin and its clinical applications. Interact Cardiovasc Thorac Surg. 2011;12:420-4 pubmed publisher
    Our goal was to determine the role of vascular endothelial growth factor (VEGF) in diagnosing of pleural effusion (PE) in order to select patients deserving of more aggressive procedures...
  78. Su M, Lin S, Lee I, Chen Y, Kuo P. Association of polymorphisms/haplotypes of the genes encoding vascular endothelial growth factor and its KDR receptor with recurrent pregnancy loss. Hum Reprod. 2011;26:758-64 pubmed publisher
    BACKGROUND Vascular endothelial growth factor (VEGF) and its kinase insert domain receptor (KDR) play an important role in angiogenesis, and their gene expression patterns also suggest a close relationship with early pregnancy...
  79. Kigel B, Rabinowicz N, Varshavsky A, Kessler O, Neufeld G. Plexin-A4 promotes tumor progression and tumor angiogenesis by enhancement of VEGF and bFGF signaling. Blood. 2011;118:4285-96 pubmed publisher
    ..plexin type specific rearrangements of the actin cytoskeleton that were accompanied by inhibition of bFGF and VEGF-induced cell proliferation...
  80. Almeida L, Melilo Carolino R, Veloso C, Pereira P, Miranda D, de Marco L, et al. Homozygosity for the +674C>T polymorphism on VEGF gene is associated with age-related macular degeneration in a Brazilian cohort. Graefes Arch Clin Exp Ophthalmol. 2012;250:185-9 pubmed publisher
    To investigate the association between VEGF gene polymorphism and age-related macular degeneration (AMD) in a Brazilian cohort...
  81. Al Habboubi H, Sater M, Almawi A, Al Khateeb G, Almawi W. Contribution of VEGF polymorphisms to variation in VEGF serum levels in a healthy population. Eur Cytokine Netw. 2011;22:154-8 pubmed publisher
    Vascular endothelial growth factor (VEGF) is a pro-angiogenic factor. Variability in VEGF expression, induced by specific VEGFA variants, are involved in angiogenesis-related disorders...
  82. Hedman M, Hartikainen J, Syvanne M, Stjernvall J, Hedman A, Kivela A, et al. Safety and feasibility of catheter-based local intracoronary vascular endothelial growth factor gene transfer in the prevention of postangioplasty and in-stent restenosis and in the treatment of chronic myocardial ischemia: phase II results of the Ku. Circulation. 2003;107:2677-83 pubmed
    Catheter-based intracoronary vascular endothelial growth factor (VEGF) gene transfer is a potential treatment for coronary heart disease...
  83. Kim D, Xu W, Kamel Reid S, Liu X, Jung C, Kim S, et al. Clinical relevance of vascular endothelial growth factor (VEGFA) and VEGF receptor (VEGFR2) gene polymorphism on the treatment outcome following imatinib therapy. Ann Oncol. 2010;21:1179-88 pubmed publisher
    Imatinib could reverse marrow angiogenesis and decrease the plasma level of vascular endothelial growth factor (VEGF) in chronic myeloid leukemia (CML) patients...
  84. Eller A, Branch D, Nelson L, Porter T, Silver R. Vascular endothelial growth factor-A gene polymorphisms in women with recurrent pregnancy loss. J Reprod Immunol. 2011;88:48-52 pubmed publisher
    ..We conclude that some allelic polymorphisms associated with altered expression of VEGFA are more common among women with RPL compared to fertile controls. ..
  85. Shenberger J, Zhang L, Powell R, Barchowsky A. Hyperoxia enhances VEGF release from A549 cells via post-transcriptional processes. Free Radic Biol Med. 2007;43:844-52 pubmed
    Exposure of animals to hyperoxia decreases lung VEGF mRNA expression concomitant with an acute increase in VEGF protein within the epithelial lining fluid (ELF)...
  86. Nikzamir A, Esteghamati A, Hammedian A, Mahmoudi T. The role of vascular endothelial growth factor +405 G/C polymorphism and albuminuria in patients with type 2 diabetes mellitus. Mol Biol Rep. 2012;39:881-6 pubmed publisher
    Observations on the association between the vascular endothelial growth factor (VEGF) gene polymorphism and nephropathy have been inconsistent, which might be due to ethnic and geographical variations...
  87. Lai Y, Zhang X, Zhang Z, Shu Y, Luo X, Yang Y, et al. The microRNA-27a: ZBTB10-specificity protein pathway is involved in follicle stimulating hormone-induced VEGF, Cox2 and survivin expression in ovarian epithelial cancer cells. Int J Oncol. 2013;42:776-84 pubmed publisher
    Previously, we demonstrated that follicle stimulating hormone (FSH) enhanced VEGF expression and facilitated ovarian cancer angiogenesis via the PI3K/AKT signaling pathway...
  88. Naim R, Sadick H, Bayerl C, Riedel F, Schafer C, Bran G, et al. Hepatocyte growth factor/scatter factor induces VEGF in human external auditory canal cholesteatoma cell culture. Int J Mol Med. 2005;15:67-71 pubmed
    ..Hepatocyte growth factor/scatter factor (HGF/SF) and vascular endothelial growth factor (VEGF) are the most important angiogenic factors in this process...
  89. Zusterzeel P, Span P, Dijksterhuis M, Thomas C, Sweep F, Massuger L. Serum vascular endothelial growth factor: a prognostic factor in cervical cancer. J Cancer Res Clin Oncol. 2009;135:283-90 pubmed publisher
    To study pre-treatment serum VEGF of patients with invasive cervical cancer and its possible role as prognostic indicator. VEGF was measured using ELISA in the largest patient group (n = 167) to date...
  90. Le Gouill S, Podar K, Amiot M, Hideshima T, Chauhan D, Ishitsuka K, et al. VEGF induces Mcl-1 up-regulation and protects multiple myeloma cells against apoptosis. Blood. 2004;104:2886-92 pubmed
    ..Vascular endothelial growth factor (VEGF) induces modest proliferation of MM cells and induces IL-6 secretion in a paracrine loop involving MM cells and ..
  91. Lim H, Blann A, Chong A, Freestone B, Lip G. Plasma vascular endothelial growth factor, angiopoietin-1, and angiopoietin-2 in diabetes: implications for cardiovascular risk and effects of multifactorial intervention. Diabetes Care. 2004;27:2918-24 pubmed
    Vascular endothelial growth factor (VEGF) and angiopoietin (Ang)-1 and Ang-2 are mediators of angiogenesis. More recent data suggest that the balance between these growth factors may affect vascular endothelial integrity...