TXK

Summary

Gene Symbol: TXK
Description: TXK tyrosine kinase
Alias: BTKL, PSCTK5, PTK4, RLK, TKL, tyrosine-protein kinase TXK, PTK4 protein tyrosine kinase 4, protein-tyrosine kinase 4, resting lymphocyte kinase
Species: human

Top Publications

  1. ncbi Effects of erythropoietin on endothelin-1 synthesis and the cellular calcium messenger system in vascular endothelial cells
    V Vogel
    Renal Section, Medical Polyclinic and Institute of Physiology I, University of Bonn, Germany
    Am J Hypertens 10:289-96. 1997
  2. ncbi Human recombinant alpha 2-HS glycoprotein is produced in insect cells as a full length inhibitor of the insulin receptor tyrosine kinase
    L Kalabay
    3rd Department of Medicine, Semmelweis University Medical School, Budapest, Hungary
    Horm Metab Res 30:1-6. 1998
  3. ncbi Space flight modulates signal transduction pathway of growth factor receptors in rat osteoblasts
    Y Kumei
    Tokyo Medical and Dental Univ
    Biol Sci Space 13:142-3. 1999
  4. ncbi Production and localization of Muc4/sialomucin complex and its receptor tyrosine kinase ErbB2 in the rat lacrimal gland
    M E Arango
    Department of Cell Biology and Anatomy, University of Miami School of Medicine, Florida 33101, USA
    Invest Ophthalmol Vis Sci 42:2749-56. 2001
  5. ncbi Human Txk: genomic organization, structure and contiguous physical linkage with the Tec gene
    Y Ohta
    Department of Pediatrics, University of South Florida, St Petersburg 33701, USA
    Oncogene 12:937-42. 1996
  6. ncbi Resting lymphocyte kinase (Rlk/Txk) phosphorylates the YVKM motif and regulates PI 3-kinase binding to T-cell antigen CTLA-4
    H Schneider
    Department of Cancer Immunology and AIDS, Harvard Medical School, Boston, Massachusetts, 02115, USA
    Biochem Biophys Res Commun 252:14-9. 1998
  7. ncbi TXK, a novel human tyrosine kinase expressed in T cells shares sequence identity with Tec family kinases and maps to 4p12
    R N Haire
    Department of Pediatrics, University of South Florida, All Children s Hospital, St Petersburg 33701
    Hum Mol Genet 3:897-901. 1994
  8. ncbi Resting lymphocyte kinase (Rlk/Txk) targets lymphoid adaptor SLP-76 in the cooperative activation of interleukin-2 transcription in T-cells
    H Schneider
    Department of Cancer Immunology and AIDS, Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Biol Chem 275:3835-40. 2000
  9. ncbi Characterization of the molecular mode of action of the sulfonylurea, glimepiride, at adipocytes
    G Muller
    Hoechst AG Frankfurt, Germany
    Horm Metab Res 28:469-87. 1996
  10. ncbi The proliferative effect of vascular endothelial growth factor requires protein kinase C-alpha and protein kinase C-zeta
    M Wellner
    , Virchow Klinikum, Humboldt University, Berlin, Germany
    Arterioscler Thromb Vasc Biol 19:178-85. 1999

Research Grants

  1. CLIFFORD RUSSELL GREYSON; Fiscal Year: 2016
  2. Phosphorylation Biosensors for Drug Discovery
    Hung Teh Kao; Fiscal Year: 2013
  3. Jan Novak; Fiscal Year: 2016
  4. Molecular Basis of Pathogenicity of IgA1-containing Immune Complexes
    Jan Novak; Fiscal Year: 2012
  5. NATHANAEL SCHIANDER GRAY; Fiscal Year: 2015
  6. Phosphotyrosine signaling pathways controlling tracheal tube geometry
    KAI G ZINN; Fiscal Year: 2013
  7. Khalid Matrougui; Fiscal Year: 2014
  8. Mutant Epidermal Growth Factor Receptor Signaling in Lung Cancer
    Udayan Guha; Fiscal Year: 2010
  9. The central role of c-Met in H. pylori pathogenesis.
    Sarah E Keates; Fiscal Year: 2010
  10. CHEMOPREVENTION WITH GREEN TEA POLYPHENON E (PPE) AND EGFR-TKIs IN HEAD AND NECK
    DONG MOON SHIN; Fiscal Year: 2011

Detail Information

Publications3041 found, 100 shown here

  1. ncbi Effects of erythropoietin on endothelin-1 synthesis and the cellular calcium messenger system in vascular endothelial cells
    V Vogel
    Renal Section, Medical Polyclinic and Institute of Physiology I, University of Bonn, Germany
    Am J Hypertens 10:289-96. 1997
    ..Therefore, the systemic hypertensive effects of EPO may be due at least in part to local stimulation of vascular endothelial ET synthesis via calcium mobilization...
  2. ncbi Human recombinant alpha 2-HS glycoprotein is produced in insect cells as a full length inhibitor of the insulin receptor tyrosine kinase
    L Kalabay
    3rd Department of Medicine, Semmelweis University Medical School, Budapest, Hungary
    Horm Metab Res 30:1-6. 1998
    ..1)...
  3. ncbi Space flight modulates signal transduction pathway of growth factor receptors in rat osteoblasts
    Y Kumei
    Tokyo Medical and Dental Univ
    Biol Sci Space 13:142-3. 1999
    ..The purpose of this study is to investigate the mRNA levels for PDGF-beta receptor, EGF receptor, Shc, and c-fos in rat osteoblasts during space flight...
  4. ncbi Production and localization of Muc4/sialomucin complex and its receptor tyrosine kinase ErbB2 in the rat lacrimal gland
    M E Arango
    Department of Cell Biology and Anatomy, University of Miami School of Medicine, Florida 33101, USA
    Invest Ophthalmol Vis Sci 42:2749-56. 2001
    ..To show the presence and forms of sialomucin complex (rat Muc4) and receptor tyrosine kinase ErbBs in the rat lacrimal gland and analyze for complexes of ErbB2 and its ligand Muc4...
  5. ncbi Human Txk: genomic organization, structure and contiguous physical linkage with the Tec gene
    Y Ohta
    Department of Pediatrics, University of South Florida, St Petersburg 33701, USA
    Oncogene 12:937-42. 1996
    b>Txk is a Tec-family tyrosine kinase expressed in mouse and human T lymphocytes...
  6. ncbi Resting lymphocyte kinase (Rlk/Txk) phosphorylates the YVKM motif and regulates PI 3-kinase binding to T-cell antigen CTLA-4
    H Schneider
    Department of Cancer Immunology and AIDS, Harvard Medical School, Boston, Massachusetts, 02115, USA
    Biochem Biophys Res Commun 252:14-9. 1998
    ..In this study, we demonstrate that Rlk (resting lymphocyte kinase) is capable of phosphorylating CTLA-4 at the YVKM motif...
  7. ncbi TXK, a novel human tyrosine kinase expressed in T cells shares sequence identity with Tec family kinases and maps to 4p12
    R N Haire
    Department of Pediatrics, University of South Florida, All Children s Hospital, St Petersburg 33701
    Hum Mol Genet 3:897-901. 1994
    A gene for a novel, putative cytoplasmic tyrosine kinase, TXK has been isolated from a human peripheral blood cDNA library...
  8. ncbi Resting lymphocyte kinase (Rlk/Txk) targets lymphoid adaptor SLP-76 in the cooperative activation of interleukin-2 transcription in T-cells
    H Schneider
    Department of Cancer Immunology and AIDS, Dana Farber Cancer Institute, Harvard Medical School, Boston, Massachusetts 02115, USA
    J Biol Chem 275:3835-40. 2000
    b>Rlk/Txk is a T-cell-specific member of the Btk/Tec family of tyrosine kinases, whereas SLP-76 is a lymphoid adaptor that is essential for pre-TcR and mature TcR signaling...
  9. ncbi Characterization of the molecular mode of action of the sulfonylurea, glimepiride, at adipocytes
    G Muller
    Hoechst AG Frankfurt, Germany
    Horm Metab Res 28:469-87. 1996
    ....
  10. ncbi The proliferative effect of vascular endothelial growth factor requires protein kinase C-alpha and protein kinase C-zeta
    M Wellner
    , Virchow Klinikum, Humboldt University, Berlin, Germany
    Arterioscler Thromb Vasc Biol 19:178-85. 1999
    ..Antisense ODN for these PKC isoforms block VEGF-induced proliferation. These findings suggest that PKC isoforms alpha and zeta are important for VEGF's angiogenic effects...
  11. ncbi Increased protein kinase C activity in myotrophin-induced myocyte growth
    P Sil
    Department of Molecular Cardiology, The Lerner Research Institute, The Cleveland Clinic Foundation, Ohio 44195, USA
    Circ Res 82:1173-88. 1998
    ..Our data suggest that myotrophin exerts its action on protein synthesis, possibly through a tyrosine kinase-coupled pathway and translocation of PKC from the cytosol to the cell membrane...
  12. pmc Clinical neurosciences in the decade of the brain: hypotheses in neuro-oncology. VEG/PF acts upon the actin cytoskeleton and is inhibited by dexamethasone: relevance to tumor angiogenesis and vasogenic edema
    G R Criscuolo
    Yale University Medical Center, New Haven, Connecticut, USA
    Yale J Biol Med 69:337-55. 1996
    ..These observations are likely to be directly linked to VEG/PF-induced endothelial cytosolic calcium flux. Insight into the mechanism of dexamethasone's clinical efficacy is also provided...
  13. ncbi NGF-resistant PC12 cell death induced by arachidonic acid is accompanied by a decrease of active PKC zeta and nuclear factor kappa B
    N J Macdonald
    Department of Human Biological Chemistry and Genetics, The University of Texas Medical Branch at Galveston, USA
    J Neurosci Res 57:219-26. 1999
    ..Our results also suggest that AA, an inflammatory signal lipid induced by TNFalpha via binding to TNFR-I, may reduce neuronal survival by inhibiting elements of the signal cascade induced by NGF...
  14. ncbi Annulate lamellae in a large cell lung carcinoma cell line with high expression of tyrosine kinase receptor and proto-oncogenes
    N S Wang
    Department of Pathology, Royal Victoria Hospital, Montreal, Quebec, Canada
    Ultrastruct Pathol 16:439-49. 1992
    ..AL are suspected to be involved in the deposition or processing of mRNA: The enhanced coexpression of AL and mRNAs of three tyrosine kinase-containing receptors in RVH-6849 cells may represent such a relationship...
  15. ncbi Reactive oxygen species in essential hypertension and non-insulin-dependent diabetes mellitus
    N N Orie
    , University of Bochum, Germany
    Am J Hypertens 12:1169-74. 1999
    ..01) compared with EH (42+/-4 nmol/L) and control subjects (35+/-3 nmol/L). Phytohemagglutinin was more effective in increasing [Ca2+]i than ROS. It is concluded that ROS may play a role in the metabolic syndrome of NIDDM but not in EH...
  16. pmc Possible roles of protein kinases in neutrophil chemotactic factor production by leucocytes in allergic inflammation in rats
    J Tanabe
    Department of Pathophysiological Biochemistry, Faculty of Pharmaceutical Sciences, Tohoku University, Miyagi, Japan
    Br J Pharmacol 113:1480-6. 1994
    ..Time-course experiments showed that the inhibitory effect by dexamethasone was apparent even 30 min after the incubation.7. Mechanism for inhibiting the production of LDNCF-1 and LDNCF-2 by dexamethasone is also discussed...
  17. ncbi RPK1, an essential yeast protein kinase involved in the regulation of the onset of mitosis, shows homology to mammalian dual-specificity kinases
    O Poch
    , Strasbourg, France
    Mol Gen Genet 243:641-53. 1994
    ..Taken together, our results suggest that Rpk1 is involved in a pathway that coordinates cell proliferation and differentiation...
  18. ncbi Effect of tumor necrosis factor-alpha on insulin signal transduction in rat adipocytes: relation to PKCbeta and zeta translocation
    A Miura
    The Third Department of Internal Medicine, Gifu University School of Medicine, Gifu 500-8705, Japan
    Biochim Biophys Acta 1449:227-38. 1999
    ..These results suggest that TNF-alpha inhibits insulin-stimulated activation of both the tyrosine kinase-IRS-1-PI3K-PKCzeta pathway and DG-PKC pathway. Finally, TNF-alpha contributes to insulin resistance in rat adipocytes...
  19. pmc Isolation and characterization of dermal lymphatic and blood endothelial cells reveal stable and functionally specialized cell lineages
    E Kriehuber
    Division of Immunology, Allergy and Infectious Diseases, Department of Dermatology, University of Vienna Medical School, Austria
    J Exp Med 194:797-808. 2001
    ..These results demonstrate that LECs and BECs constitute stable and specialized EC lineages equipped with the potential to navigate leukocytes and, perhaps also, tumor cells into and out of the tissues...
  20. pmc Vascular actions of thrombin receptor-derived polypeptides: structure-activity profiles for contractile and relaxant effects in rat aorta
    A A Laniyonu
    Department of Pharmacology and Therapeutics, University of Calgary, Faculty of Medicine, AB Canada
    Br J Pharmacol 114:1680-6. 1995
    ....
  21. pmc Activation of rabbit platelets by Ca2+ influx and thromboxane A2 release in an external Ca(2+)-dependent manner by zooxanthellatoxin-A, a novel polyol
    M C Rho
    Department of Pharmaceutical Molecular Biology, Faculty of Pharmaceutical Sciences, Tohoku University, Sendai, Japan
    Br J Pharmacol 115:433-40. 1995
    ..The resulting increase in [Ca2+]i subsequently stimulates the secondary release of TXA2 from platelets. Furthermore, the response to ZT-A may be associated with tyrosine phosphorylation...
  22. ncbi The role of nitric oxide in parasitic diseases
    F Y Liew
    Department of Immunology, University of Glasgow
    Ann Trop Med Parasitol 87:637-42. 1993
    ..The regulatory pathways involve tyrosine kinase and protein kinase C...
  23. ncbi The upregulating effect of insulin and vanadate on cell surface insulin receptors in rat adipocytes is modulated by glucose and energy availability
    Z W Yu
    Department of Medicine, Norrland University Hospital, , Sweden
    Horm Metab Res 32:310-5. 2000
    ..In conclusion, the effect of insulin and vanadate to upregulate cell-surface insulin receptors is energy-dependent and to some extent specifically glucose-dependent...
  24. pmc Subtype-specific translocation of the delta subtype of protein kinase C and its activation by tyrosine phosphorylation induced by ceramide in HeLa cells
    T Kajimoto
    Laboratory of Molecular Pharmacology, Biosignal Research Center, Kobe University, Nada-ku, Kobe 657-8501, Japan
    Mol Cell Biol 21:1769-83. 2001
    ....
  25. ncbi Receptors for insulin-like growth factors in the central nervous system: structure and function
    S Gammeltoft
    Department of Clinical Chemistry, Bispebjerg Hospital, Copenhagen NV, Denmark
    Horm Metab Res 20:436-42. 1988
    ..Based on these findings we suggest that IGF receptors in brain undergo changes during fetal development and malignant transformation.(ABSTRACT TRUNCATED AT 250 WORDS)..
  26. ncbi Interleukin-1-induced ether-linked diglycerides inhibit calcium-insensitive protein kinase C isotypes. Implications for growth senescence
    A Mandal
    Department of Physiology and Biophysics, Case Western Reserve University, Cleveland, Ohio 44106-4949, USA
    J Biol Chem 272:20306-11. 1997
    ..This signaling mechanism implicates cytokine receptor-induced ether-linked diglycerides as second messengers that inhibit the bioactivity of calcium-insensitive protein kinase C isotypes resulting in growth arrest...
  27. pmc Opioid modulation of extracellular signal-regulated protein kinase activity is ras-dependent and involves Gbetagamma subunits
    M M Belcheva
    E. A. Doisy Department of Biochemistry and Molecular Biology, St. Louis University School of Medicine, Missouri 63104-1079, USA
    J Neurochem 70:635-45. 1998
    ..These results suggest a mechanism involving Ras and betagamma subunits of Gi/o proteins in opioid agonist activation of ERK1 and ERK2, as well as opioid modulation of epidermal growth factor-induced ERK activity...
  28. ncbi Down-modulation of P210bcr/abl induces apoptosis/differentiation in K562 leukemic blast cells
    A B Deora
    Chemotherapy and Stem Cell Biology Division, Tata Memorial Center, Parel, Mumbai, India
    Tumori 83:756-61. 1997
    ....
  29. ncbi Control of DAF-7 TGF-(alpha) expression and neuronal process development by a receptor tyrosine kinase KIN-8 in Caenorhabditis elegans
    M Koga
    Department of Biology, Graduate School of Sciences, Kyushu University, Fukuoka, Japan
    Development 126:5387-98. 1999
    ..KIN-8 is required for the process development of ASI, and also involved in promotion of daf-7 expression through a physiological or developmental function...
  30. pmc Rapid desensitization of adrenaline- and neuropeptide Y-stimulated Ca2+ mobilization in HEL-cells
    M C Michel
    Dept Medicine, University of Essen, Germany
    Br J Pharmacol 112:499-504. 1994
    ....
  31. ncbi Hybrid tyrosine kinase/cytokine receptors transmit mitogenic signals in response to ligand
    R E Pacifici
    Department of Molecular Biology, Amgen Inc, Amgen Center, Thousand Oaks, California 91320
    J Biol Chem 269:1571-4. 1994
    ....
  32. ncbi Protein A-activated rat splenic lymphocyte proliferation involves tyrosine kinase-phospholipase C-protein kinase C pathway
    T Das
    Immunotechnology Section, Bose Institute, Calcutta, India
    Immunopharmacol Immunotoxicol 22:75-90. 2000
    ..These observations will be of valid help in correlating the immunostimulatory activities of PA with the molecular mechanism(s) of its action...
  33. ncbi Signaling mechanisms of basic fibroblast growth factor in arterial cells from genetically hypertensive rat
    D L Zhu
    CNRS URA 1482, Laboratoire de Pharmacologie, , Paris, France
    Am J Hypertens 7:351-6. 1994
    ..Therefore, one may envisage that bFGF contributes, through paracrine/autocrine mechanisms, to the vascular smooth muscle hyperplasia/hypertrophy in SHR...
  34. ncbi The regulation of trabecular meshwork and ciliary muscle contractility
    M Wiederholt
    , , , Germany
    Prog Retin Eye Res 19:271-95. 2000
    ..This profile makes these substances appear as ideal drugs for simultaneously improving ocular outflow and retinal circulation, parameters that determine the time course of visual deterioration in glaucoma...
  35. ncbi Involvement of insulin-like growth factor-I in inner ear organogenesis and regeneration
    Y Leon
    Instituto de Investigaciones Biomedicas, Consejo Superior de Investigaciones Cientificas CSIC, Madrid, Spain
    Horm Metab Res 31:126-32. 1999
    ..The combinatorial expression of jun and Fos family members in particular domains of the otic vesicle would be the final result of such cascade. Some of these mechanisms may be also implicated in otic regeneration...
  36. ncbi Properties of tripartite chimeras between Src and Lck
    A Kashishian
    Fred Hutchinson Cancer Research Center, Seattle, Washington 98104
    Oncogene 5:1463-70. 1990
    ..Enzymatic dephosphorylation stimulated the in vitro kinase activity of parental Src, but not of SLS or SLL. These observations suggest that chimeric Src-Lck molecules are regulated in the cell, but not in vitro...
  37. ncbi In vivo modulators of antibody kinetics
    A Jekunen
    Department of Oncology, Helsinki University Central Hospital, Helsinki
    Acta Oncol 35:267-71. 1996
    ..This type of manipulation provides an opportunity to optimize radioimmunotherapy...
  38. ncbi Insulin action is mimicked by polyclonal antireceptor antibodies that activate the insulin receptor tyrosine kinase
    M Caron
    Laboratoire de Biochimie, INSERM U181, , Paris, France
    Horm Metab Res 21:295-300. 1989
    ..Taken together, these results are consistent with a role for the kinase activity of the insulin receptor in mediating the action of insulin...
  39. pmc The role of capacitative Ca2+ influx in the alpha 1B-adrenoceptor-mediated contraction to phenylephrine of the rat spleen
    R P Burt
    Department of Pharmacology, University College London
    Br J Pharmacol 116:2327-33. 1995
    ..This suggests that inositol triphosphate but not diacylglycerol is involved in the contraction...
  40. ncbi Hypertension, diabetes mellitus, and insulin resistance: the role of intracellular magnesium
    G Paolisso
    Department of Geriatric Medicine and Metabolic Diseases, II University of Naples, Italy
    Am J Hypertens 10:346-55. 1997
    ..We further suggest that a reduced intracellular magnesium concentration might be the missing link helping to explain the epidemiological association between NIDDM and hypertension...
  41. ncbi Strain induces Caco-2 intestinal epithelial proliferation and differentiation via PKC and tyrosine kinase signals
    O Han
    Department of Surgery, Yale University School of Medicine, New Haven 06520-8062, USA
    Am J Physiol 275:G534-41. 1998
    ..These results suggest that cyclic deformation may modulate intestinal epithelial proliferation and brush-border enzyme activity by regulating PKC and tyrosine kinase signals...
  42. ncbi Effects of mercuric chloride exposure on the glutamate uptake by cultured retinal pigment epithelial cells
    T A Toimela
    Tampere University Medical School, FIN-33014 University of Tampere, Finland
    Toxicol In Vitro 15:7-12. 2001
    ..However, PKC is not likely to be the only regulator of glutamate uptake. The rise observed in [Ca(2+)](i) may initiate various cellular events during mercury intoxication...
  43. ncbi Sequential involvement of Lck and SHP-1 with MHC-recognizing receptors on NK cells inhibits FcR-initiated tyrosine kinase activation
    B A Binstadt
    Department of Immunology, Mayo Clinic and Foundation, Rochester, Minnesota 55905, USA
    Immunity 5:629-38. 1996
    ..These results suggest sequential roles for Lck and SHP-1 in the inhibition of PTK following MHC recognition by NK cells...
  44. pmc Interactions of chloroethylclonidine with rauwolscine- and prazosin-sensitive adrenoceptors in dog saphenous vein
    A M Low
    Department of Biomedical Sciences, McMaster University, Hamilton, Ontario, Canada
    Br J Pharmacol 113:1263-8. 1994
    ..The inhibitory effect on CEC-induced contraction that depended on external Ca2+ by genistein suggests a role forty rosine kinase in the regulation of dihydropyridine-insensitive Ca2+ entry...
  45. ncbi [Abnormalities of the p53, N-ras, DCC and FLT-3 genes in myelodysplastic syndromes]
    K Nakamura
    Department of 3rd Internal Medicine, Nippon Medical School, Tokyo, Japan
    J Nippon Med Sch 68:143-8. 2001
    ..Abnormalities of p53 and DCC genes were significantly associated with survival time (p< 0.02, p< 0.004, respectively)...
  46. ncbi A lipid A analog inhibits LPS-induced cytokine expression and improves survival in endotoxemic mice
    K Someya
    New Product Research Laboratories I, Daiichi Pharmaceutical Co, Tokyo, Japan
    Immunopharmacol Immunotoxicol 18:477-95. 1996
    ..These results suggest that monosaccharidic lipid A analog such as DY-9973 can inhibit LPS-induced activation of macrophages and that it reduces lethal toxicity of LPS...
  47. pmc Mode of action of thrombin in the rabbit aorta
    D Godin
    , , Canada
    Br J Pharmacol 115:903-8. 1995
    ..5. Altogether these results suggest the existence of subtle differences between the mode of action of thrombin and of synthetic peptides related to the N-terminal thrombin receptor sequence, in the rabbit aorta...
  48. ncbi Protein kinase C-zeta and phosphoinositide-dependent protein kinase-1 are required for insulin-induced activation of ERK in rat adipocytes
    M P Sajan
    J. A. Haley Veterans Hospital Research Service, Department of Internal Medicine, University of South Florida College of Medicine, Tampa, Florida 33612, USA
    J Biol Chem 274:30495-500. 1999
    ..Our findings therefore suggested that PDK-1 and PKC-zeta serve as a downstream effectors of PI3K, and act in conjunction with GRB2, SOS, RAS, and RAF, to activate MEK and ERK during insulin action in rat adipocytes...
  49. ncbi Insulin-like growth factor system in neuroblastoma tumorigenesis and apoptosis: potential diagnostic and therapeutic perspectives
    W Zumkeller
    German Cancer Research Centre, Division of Cytogenetics, Heidelberg, Germany
    Horm Metab Res 31:138-41. 1999
    ..This review highlights the role of the IGF-system in neuroblastoma and points at possible modulators with the aim of inducing differentiation or apoptosis of tumor cells...
  50. ncbi Platelet-derived growth factor. Structure, function and implications in normal and malignant cell growth
    B Westermark
    Department of Pathology, University Hospital, Uppsala, Sweden
    Acta Oncol 32:101-5. 1993
    ..This view is supported by our recent finding that human melanoma cells that have been stably transfected with a PDGF B-chain cDNA, elicit a stroma response when transplanted to nude mice...
  51. ncbi Possible role of tyrosine kinases in the prolactin stimulation of cell division in Nb2 node lymphoma cells
    G Fan
    Department of Physiology, Wayne State University School of Medicine, Detroit, Michigan
    Horm Metab Res 25:256-8. 1993
    ....
  52. ncbi Arachidonic acid induces c-jun gene expression in stromal cells stimulated by interleukin-1 and tumor necrosis factor-alpha: evidence for a tyrosine-kinase-dependent process
    M T Rizzo
    Division of Hematology and Bone Marrow Transplantation, Parma University School of Medicine, Italy
    Blood 86:2967-75. 1995
    ..abstract truncated at 400 words)..
  53. ncbi Novel tyrosine kinase inhibitors in the treatment of cancer
    Alberto Ocana
    Drug Development Program, Princess Margaret Hospital, Toronto, Canada
    Curr Drug Targets 10:575-6. 2009
    ....
  54. ncbi Doxazosin lowers blood pressure and improves insulin responses to a glucose load with no changes in tyrosine kinase activity or insulin binding
    L J Dominguez
    Division of Endocrinology, Wayne State University, Detroit, Michigan 48201, USA
    Am J Hypertens 8:528-32. 1995
    ..No significant correlation was found between the insulin or glucose responses and the insulin receptor binding or tyrosine kinase activity before and after treatment...
  55. ncbi ZD6474 inhibits vascular endothelial growth factor signaling, angiogenesis, and tumor growth following oral administration
    Stephen R Wedge
    Department of Cancer and Infection Research, AstraZeneca, Cheshire SK10 4TG, United Kingdom
    Cancer Res 62:4645-55. 2002
    ..4 cm(3) volume. ZD6474 is currently in Phase I clinical development as a once-daily oral therapy in patients with advanced cancer...
  56. pmc Cytokine-mediated induction of cyclo-oxygenase-2 by activation of tyrosine kinase in bovine endothelial cells stimulated by bacterial lipopolysaccharide
    P Akarasereenont
    William Harvey Research Institute, St Bartholomew s Hospital Medical College, London
    Br J Pharmacol 115:401-8. 1995
    ....
  57. ncbi Identification, cloning, and characterization of a novel human T-cell-specific tyrosine kinase located at the hematopoietin complex on chromosome 5q
    S Gibson
    Oncology Research Division, Toronto General Hospital, Ontario, Canada
    Blood 82:1561-72. 1993
    ..Furthermore, the 5q31-32 region is implicated in the genesis of the 5q- syndrome associated with myelodysplasia and development of leukemia.(ABSTRACT TRUNCATED AT 400 WORDS)..
  58. ncbi Interleukin 6 signal transduction in a human hepatoma cell line (Hep G2)
    D Thompson
    Department of Clinical Medicine, Old Medical School, University of Leeds, United Kingdom
    Immunopharmacol Immunotoxicol 15:371-86. 1993
    ..There was no evidence to suggest that protein kinase C had a stimulatory role although this or a related kinase may be involved in down-regulating the interleukin 6 signal...
  59. ncbi Effects of the tyrosine kinase inhibitor AG957 and an Anti-Fas receptor antibody on CD34(+) chronic myelogenous leukemia progenitor cells
    C Carlo-Stella
    Department of Hematology, University of Parma, Parma, Italy
    Blood 93:3973-82. 1999
    ..These data may have significant therapeutic applications...
  60. ncbi Internalization and degradation of insulin by a human insulin receptor-v-ros hybrid in Chinese hamster ovary cells
    J Hari
    Second Department of Internal Medicine, Kobe University School of Medicine, Japan
    Biochem Biophys Res Commun 158:705-11. 1989
    ....
  61. ncbi Interleukin-3 regulates the activity of the LYN protein-tyrosine kinase in myeloid-committed leukemic cell lines
    T Torigoe
    Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia
    Blood 80:617-24. 1992
    ..These observations provide the first example of an IL-3--regulable PTK, and strongly suggest that the p53/56-LYN kinase participates in early IL-3--initiated signalling events, at least in some human leukemic cell lines...
  62. ncbi A chimeric EGFR/neu receptor in functional analysis of the neu oncoprotein
    L Lehtola
    Department of Virology, University of Helsinki, Finland
    Acta Oncol 31:147-50. 1992
    ..In the future we plan to focus on characterization of possible differences between EGFR and neu signalling in more differentiated cellular backgrounds...
  63. ncbi 2,3,7,8-Tetrachlorodibenzo-p-dioxin-induced activation of a protein tyrosine kinase, pp60src, in murine hepatic cytosol using a cell-free system
    A Blankenship
    Department of Environmental Toxicology and the Center for Environmental Health Sciences, University of California, Davis, Davis, California 95616, USA
    Mol Pharmacol 52:667-75. 1997
    ....
  64. ncbi Serine and alanine racemase activities of VanT: a protein necessary for vancomycin resistance in Enterococcus gallinarum BM4174
    C A Arias
    Department of Biochemistry, University of Cambridge, Tennis Court Road, The Downing Site, Cambridge CB2 1QW, UK
    Microbiology 146:1727-34. 2000
    ..To investigate the selectivity of racemization of L-Ser or L-Ala by VanT, a strain of Escherichia coli TKL-10 that requires D-Ala for growth at 42 degrees C was used as host for transformation experiments using plasmids ..
  65. ncbi Dasatinib: a tyrosine kinase inhibitor for the treatment of chronic myelogenous leukemia and philadelphia chromosome-positive acute lymphoblastic leukemia
    Michael Steinberg
    Department of Pharmacy Practice, Massachusetts College of Pharmacy and Health Sciences, 19 Foster Street, Worcester, MA 01608, USA
    Clin Ther 29:2289-308. 2007
    ..The oral TK inhibitor dasatinib was approved in 2006 for use in patients with CML or Philadelphia chromosome-positive acute lymphoblastic leukemia (ALL) who are unable to tolerate or have not responded to other treatments...
  66. ncbi Diacylglycerols modulate insulin action in rat adipocytes
    M L Terry
    Department of Internal Medicine, Wayne State University School of Medicine, Detroit, Michigan
    Horm Metab Res 23:266-70. 1991
    ....
  67. ncbi Cytokine receptor signal transduction mechanisms in immuno-hematopoietic cells
    V Chiarugi
    Laboratory of Molecular Biology, University of Florence
    Tumori 79:92-9. 1993
    ..Three of five classes of receptors show the involvement of tyrosine kinase activity as the key step in signal transduction. The importance of tyrosine phosphorylation in cellular response to cytokines is pointed out...
  68. ncbi Antiangiogenic and antitumor activity of a novel vascular endothelial growth factor receptor-2 tyrosine kinase inhibitor ZD6474 in a metastatic human pancreatic tumor model
    Claudius Conrad
    Department of Surgery, University of Munich Grosshadern LMU, Munich, Germany
    Anticancer Drugs 18:569-79. 2007
    ..ZD6474 decreased primary pancreatic tumor growth and reduced lymph node and liver metastases compared with controls or gemcitabine alone. Tumor growth was inhibited further in animals receiving ZD6474 and gemcitabine in combination...
  69. ncbi Tyrosine kinase B and C receptors in the neostriatum and nucleus accumbens are co-localized in enkephalin-positive and enkephalin-negative neuronal profiles and their expression is influenced by cocaine
    A Y Freeman
    Laboratory of Neuropsychopharmacology, Department of Pharmacology, R 612, Boston University School of Medicine, 715 Albany Street, Boston 02118, USA
    Neuroscience 117:147-56. 2003
    ....
  70. pmc Regulated binding of PTP1B-like phosphatase to N-cadherin: control of cadherin-mediated adhesion by dephosphorylation of beta-catenin
    J Balsamo
    Department of Biological Sciences, Wayne State University, Detroit, Michigan 48202, USA
    J Cell Biol 134:801-13. 1996
    ..In this manner the GalNAcPTase-proteoglycan interaction may play a major role in morphogenetic cell and tissue interactions during development...
  71. ncbi Novel 4-anilinoquinazolines with C-7 basic side chains: design and structure activity relationship of a series of potent, orally active, VEGF receptor tyrosine kinase inhibitors
    Laurent F Hennequin
    AstraZeneca, Centre de Recherches, Z I la Pompelle, B P 1050, Chemin de Vrilly, 51689 Reims, Cedex 2, France
    J Med Chem 45:1300-12. 2002
    ..001, Mann Whitney rank sum test), and substantial inhibition (36%, P < 0.02) was evident with 12.5 mg/kg/day...
  72. ncbi Stimulation of M3 muscarinic receptors induces phosphorylation of the Cdc42 effector activated Cdc42Hs-associated kinase-1 via a Fyn tyrosine kinase signaling pathway
    D A Linseman
    Department of Pharmacology and Neuroscience Laboratory, Mental Health Research Institute, University of Michigan, Ann Arbor, Michigan 48104 1687, USA
    J Biol Chem 276:5622-8. 2001
    ..The data are the first to show phosphorylation of ACK-1 after stimulation of a receptor coupled to neurite outgrowth and indicate that a Rho family GTPase (i.e. Cdc42) and Fyn are essential upstream elements of this signaling pathway...
  73. ncbi YM-359445, an orally bioavailable vascular endothelial growth factor receptor-2 tyrosine kinase inhibitor, has highly potent antitumor activity against established tumors
    Nobuaki Amino
    Pharmacology Laboratories, Molecular Medicine Laboratories, Yamanouchi Pharmaceutical Co Ltd, Tsukuba, Japan
    Clin Cancer Res 12:1630-8. 2006
    ..The aim of this study was to analyze the efficacy of this compound both in vitro and in vivo...
  74. pmc Transmembrane signaling by a chimera of the Escherichia coli aspartate receptor and the human insulin receptor
    G R Moe
    Department of Biochemistry, University of California, Berkeley, CA 94720
    Proc Natl Acad Sci U S A 86:5683-7. 1989
    ..These results indicate that features of the signaling mechanisms used by these diverse receptors are conserved, but that interesting changes in the protein properties are caused by differences in the neighboring domains...
  75. ncbi Selective inhibition of the epidermal growth factor receptor tyrosine kinase by BIBX1382BS and the improvement of growth delay, but not local control, after fractionated irradiation in human FaDu squamous cell carcinoma in the nude mouse
    M Baumann
    Clinic of Radiation Oncology, Medical Faculty Carl Gustav Carus, University of Technology, Dresden, Germany
    Int J Radiat Biol 79:547-59. 2003
    ..FaDu human squamous cell carcinoma is epidermal growth factor receptor positive and significant repopulation during fractionated irradiation was demonstrated in previous experiments...
  76. ncbi Glucose transporter (GLUT 4) content and insulin receptor kinase activity in muscles of the LA/N-cp rat
    M Kern
    Department of Medicine, Stanford University School of Medicine, California
    Horm Metab Res 26:129-32. 1994
    ..These data indicate that there are at least two defects in the insulin action cascade in muscle from LA/N-cp rats that contribute to the insulin resistance in these animals...
  77. pmc Partial purification and characterization of the lck protein-tyrosine kinase from bovine thymus
    Q M Wang
    Department of Medicinal Chemistry and Pharmacognosy, School of Pharmacy, Purdue University, West Lafayette, IN 47907
    Biochem J 279:567-74. 1991
    ..The phosphorylation of angiotensin I by bovine thymus p56lck was weakly activated by polyionic compounds such as heparin and polylysine, and was strongly activated by high concentrations of NaCl...
  78. ncbi Characterization of cancer stem cells in chronic myeloid leukaemia
    H G Jørgensen
    Section of Experimental Haematology, Division of Cancer Sciences and Molecular Pathology, University of Glasgow, Level 3 Queen Elizabeth Building, Royal Infirmary, 10 Alexandra Parade, Glasgow G31 2ER, U K
    Biochem Soc Trans 35:1347-51. 2007
    ..Our intentions are now to explore the activity of BMS-214662 in other cancer stem cell disorders and to move this preclinical work to a clinical trial combining dasatinib with BMS-214662 in CML...
  79. ncbi [Involvement of protein tyrosine kinases in β-amyloid protein-induced suppression of long-term potentiation in the rat hippocampal CA1 region in vivo]
    Fen Guo
    Department of Physiology, Shanxi Medical University, Taiyuan, China
    Sheng Li Xue Bao 61:263-71. 2009
    ....
  80. pmc Effects of tyrosine kinase inhibitors on the contractility of rat mesenteric resistance arteries
    C Toma
    Department of Pharmacology, Aarhus University, Denmark
    Br J Pharmacol 114:1266-72. 1995
    ..However, the results must be interpreted cautiously because the enzyme inhibitors may have a poor specificity in intact tissues and because the presumed inactive analogues had potent effects...
  81. ncbi Tyrosine kinase and phosphatidylinositol 3-kinase activation are required for cyclic adenosine 3',5'-monophosphate-dependent potentiation of deoxyribonucleic acid synthesis induced by insulin-like growth factor-I in FRTL-5 cells
    T Nedachi
    Department of Animal Sciences, Graduate School of Agriculture and Life Sciences, The University of Tokyo, Japan
    Endocrinology 141:2429-38. 2000
    ..These mechanisms appear to be necessary for cAMP-dependent potentiation of the DNA synthesis induced by IGF-I...
  82. ncbi Regulation of lipopolysaccharide-induced inducible nitric-oxide synthase expression through the nuclear factor-kappaB pathway and interferon-beta/tyrosine kinase 2/Janus tyrosine kinase 2-signal transducer and activator of transcription-1 signaling cascad
    Hye Jung Kim
    Department of Pharmacology, College of Medicine, Gyeongsang National University, 92 Chilam dong, Jinju, South Korea
    J Pharmacol Exp Ther 320:782-9. 2007
    ..Thus, THI 53 may regulate LPS-mediated inflammatory response through both the NF-kappaB and IFN-beta/Tyk2/JAK2-STAT-1 pathways...
  83. ncbi Contractile effects of angiotensin peptides in rat aorta are differentially dependent on tyrosine kinase activity
    G Petrescu
    Department of Physiology, University of Medicine and Pharmacy Gr T Popa, Iasi, Romania
    J Renin Angiotensin Aldosterone Syst 2:180-7. 2001
    ..An elevation of intracellular calcium via tyrosine kinase-mediated processes may mediate the actions of G-protein coupled receptor agonists in smooth muscle, including angiotensin peptides...
  84. ncbi Effects of protein kinase C on delayed rectifier K+ channel regulation by tyrosine kinase in rat retinal pigment epithelial cells
    Olaf Strauss
    Institute for Clinical Physiology, Benjamin Franklin University Clinic, Free University of Berlin, Hindenburgdamm 30, 12200 Berlin, Germany
    Invest Ophthalmol Vis Sci 43:1645-54. 2002
    ..Investigation of the regulation of delayed rectifier potassium channels by protein kinases in retinal pigment epithelial (RPE) cells...
  85. ncbi Extra-virgin olive oil polyphenols inhibit HER2 (erbB-2)-induced malignant transformation in human breast epithelial cells: relationship between the chemical structures of extra-virgin olive oil secoiridoids and lignans and their inhibitory activities on
    Javier A Menendez
    Catalan Institute of Oncology ICO, Girona Biomedical Research Institute IdIBGi, Spain
    Int J Oncol 34:43-51. 2009
    ....
  86. ncbi [Bcr-Abl inhibition as molecular therapy approach in chronic myeloid leukemia]
    Elisabeth Buchdunger
    Präklinische Forschung Onkologie, Novartis Pharma AG, Basel, Schweiz
    Med Klin (Munich) 97:2-6. 2002
    ..Recent studies with clinical samples from resistant patients have shown that point mutations in the kinase domain of Bcr-Abl play a role in the development of resistance to STI571...
  87. ncbi Novel 5-substituted, 2,4-diaminofuro[2,3-d]pyrimidines as multireceptor tyrosine kinase and dihydrofolate reductase inhibitors with antiangiogenic and antitumor activity
    Aleem Gangjee
    Division of Medicinal Chemistry, Graduate School of Pharmaceutical Sciences, Duquesne University, 600 Forbes Avenue, Pittsburgh, PA 15282, USA
    Bioorg Med Chem 13:5475-91. 2005
    ..In addition, both 18 and 32 were also active in decreasing lung metastases in a mouse model of B16 melanomas...
  88. ncbi Activation of epidermal growth factor receptor by epidermal growth factor
    J M Sherrill
    Department of Chemistry, University of California, San Diego, La Jolla 92093 0506, USA
    Biochemistry 35:5705-18. 1996
    ..In this mechanism, dimeric EGF receptor must be occupied by two molecules of EGF for enzymatic activity to be expressed...
  89. ncbi Role of tyrosine kinase in serotonin-induced constriction of the basilar artery in vivo
    T Kitazono
    Second Department of Internal Medicine, Faculty of Medicine, Kyushu University, Fukuoka, Japan
    Stroke 29:494-7; discussion 498. 1998
    ..The objective of this study was to test the hypothesis that activation of tyrosine kinase contributes to serotonin-induced constriction of the basilar artery in vivo...
  90. ncbi Looking for an insulin pill? Use the BRET methodology!
    T Issad
    Department of Cell Biology, Institut Cochin, CNRS UMR 8104, INSERM U567, Universite Paris V, Paris, France
    Diabetes Metab 29:111-7. 2003
    ..Therefore, this methodology can also be used in high-throughput screening for the search of molecules that will specifically disrupt the interaction between the insulin receptor and PTP1B...
  91. ncbi Expression of focal adhesion kinase (p125 FAK) and proline-rich tyrosine kinase 2 (PYK2/CAKb) in cerebral metastases, correlation with VEGF-R-, ecNOS III-labelling and morphometric data
    H C Ludwig
    Georg August Universitat, Gottingen, Germany
    Anticancer Res 20:1419-24. 2000
    ..A further analysis was performed to morphometrically evaluate tumour and oedema volumes and to correlate the immunohistochemical data in a subgroup of 40 patients...
  92. ncbi An update of the mechanisms of resistance to EGFR-tyrosine kinase inhibitors in breast cancer: Gefitinib (Iressa) -induced changes in the expression and nucleo-cytoplasmic trafficking of HER-ligands (Review)
    Laura Ferrer-Soler
    Girona Biomedical Research Institute IdIBGi, Dr Josep Trueta University Hospital of Girona, Girona, Catalonia, Spain
    Int J Mol Med 20:3-10. 2007
    ....
  93. ncbi Involvement of G(i) proteins and Src tyrosine kinase in TNFalpha production induced by lipopolysaccharide, group B Streptococci and Staphylococcus aureus
    Hongkuan Fan
    Department of Physiology and Neuroscience, Medical University of South Carolina, 173 Ashley Avenue, BSB Room 403, Charleston, SC 29425, USA
    Cytokine 22:126-33. 2003
    ..However, unlike LPS, involvement of PI3 Kinase in Gram-positive bacteria induced signaling pathways are species dependent...
  94. ncbi The nonreceptor tyrosine kinase ACK2, a specific target for Cdc42 and a negative regulator of cell growth and focal adhesion complexes
    W Yang
    Department of Molecular Medicine, Cornell University, Ithaca, New York 14853, USA
    J Biol Chem 276:43987-93. 2001
    ....
  95. pmc Phosphotyrosine binding domain-dependent upregulation of the platelet-derived growth factor receptor alpha signaling cascade by transforming mutants of Cbl: implications for Cbl's function and oncogenicity
    D P Bonita
    Department of Medicine, Brigham and Women s Hospital, Harvard Medical School, Boston, Massachusetts 02115, USA
    Mol Cell Biol 17:4597-610. 1997
    ..Altogether, these findings identify a novel mechanism of Cbl's physiological function and oncogenesis, involving its PTB domain-dependent direct interaction with cellular tyrosine kinases...
  96. ncbi Phosphatidylinositol 3-kinase-dependent membrane association of the Bruton's tyrosine kinase pleckstrin homology domain visualized in single living cells
    P Varnai
    Endocrinology and Reproduction Research Branch, NICHD, National Institutes of Health, Bethesda, Maryland 20892 4510, USA
    J Biol Chem 274:10983-9. 1999
    ....
  97. ncbi Effect of in vivo administered hexachlorobenzene on epidermal growth factor receptor levels, protein tyrosine kinase activity, and phosphotyrosine content in rat liver
    Andrea S Randi
    Departamento de Bioqui mica Humana, Facultad de Medicina, Universidad de Buenos Aires, Paraguay 2155, 5to piso, CP 1121, Buenos Aires, Argentina
    Biochem Pharmacol 65:1495-506. 2003
    ..The level of sensitivity encountered in our studies is extraordinary, occurring at 1/10 to 1/1000 the doses of HCB known to cause other toxicological lesions...
  98. ncbi Insulin resistance and diabetes due to different mutations in the tyrosine kinase domain of both insulin receptor gene alleles
    J Kusari
    Department of Medicine, University of California, La Jolla 92093
    J Biol Chem 266:5260-7. 1991
    ....
  99. ncbi The role of cetuximab in the treatment of squamous cell cancer of the head and neck
    Barbara Burtness
    Fox Chase Cancer Center, 333 Cottman Ave, Philadelphia, PA 19111, USA
    Expert Opin Biol Ther 5:1085-93. 2005
    ..Thus, cetuximab is biologically active across a range of clinical scenarios in squamous cell carcinoma of the head and neck. Ongoing studies will be important in establishing its role in the routine management of head and neck cancer...
  100. pmc Multiple effects and stimulation of insulin secretion by the tyrosine kinase inhibitor genistein in normal mouse islets
    J C Jonas
    , Faculty of Medicine, University of Louvain, Brussels, Belgium
    Br J Pharmacol 114:872-80. 1995
    ..The unusual mechanisms, by which genistein increases insulin release in spite of a decrease in beta-cell [Ca2+]i and without activating known signalling pathways, do not seem to result from an inhibition of tyrosine kinases...
  101. ncbi Phosphorylation of GAP and GAP-associated proteins by transforming and mitogenic tyrosine kinases
    C Ellis
    Division of Molecular and Developmental Biology, Mount Sinai Hospital Research Institute, Toronto, Ontario, Canada
    Nature 343:377-81. 1990
    ..These data support the idea that SH2 sequences direct the interactions of cytoplasmic proteins involved in signal transduction...

Research Grants84

  1. CLIFFORD RUSSELL GREYSON; Fiscal Year: 2016
    ..Agents with potential clinical utility will be identified using the isolated papillary muscle model and tested in the pig model. ..
  2. Phosphorylation Biosensors for Drug Discovery
    Hung Teh Kao; Fiscal Year: 2013
    ..Finally, this new technology will be convertible to a wide array of protein kinases, greatly expanding the number of drug targets that may potentially be screened. ..
  3. Jan Novak; Fiscal Year: 2016
    ..Relevance: The results will shed light on the pathogenesis of IgAN and identify therapeutic targets for disease-specific treatment of IgAN as well as potential response/prognostic biomarkers. ..
  4. Molecular Basis of Pathogenicity of IgA1-containing Immune Complexes
    Jan Novak; Fiscal Year: 2012
    ..Relevance: The improved understanding of the pathogenesis of IgAN will identify therapeutic targets for disease-specific therapy of IgAN as well as potential prognostic biomarkers. ..
  5. NATHANAEL SCHIANDER GRAY; Fiscal Year: 2015
    ....
  6. Phosphotyrosine signaling pathways controlling tracheal tube geometry
    KAI G ZINN; Fiscal Year: 2013
    ..We can also analyze tyrosine phosphorylation of the proteins and determine if they physically interact with each other in the embryo. ..
  7. Khalid Matrougui; Fiscal Year: 2014
    ..The goal of our studies is to determine how increased Epidermal Growth Factor Receptor tyrosine kinase activity compromises coronary arteriolar function in type 2 diabetes. ..
  8. Mutant Epidermal Growth Factor Receptor Signaling in Lung Cancer
    Udayan Guha; Fiscal Year: 2010
    ..This proposal is aimed at elucidating the signaling pathways that relay the signals from mutant EGFRs to promote cancer cell survival and proliferation and validate those targets of mutant EGFR in lung cancer patients. ..
  9. The central role of c-Met in H. pylori pathogenesis.
    Sarah E Keates; Fiscal Year: 2010
    ..Results from these studies should lead to a better understanding of the disease mechanisms involved in the development of H. pylori-mediated gastric carcinogenesis. ..
  10. CHEMOPREVENTION WITH GREEN TEA POLYPHENON E (PPE) AND EGFR-TKIs IN HEAD AND NECK
    DONG MOON SHIN; Fiscal Year: 2011
    ..This may be further enhanced by the identification of tumor markers that can serve as indicators for treatment efficacy. ..
  11. Daniel J Leahy; Fiscal Year: 2015
    ..We have recently extended our expression and purification to HER2, HER3, and HER4, and we propose to carry out similar mechanistic and enzymological studies of the intrinsic and regulated activity of these ErbBs. ..
  12. Molecular Mechanisms of EGF Signaling &Iressa/Tarceva Inhibition in NSCLC
    Karen S Anderson; Fiscal Year: 2012
    ..The studies described in this application are designed help unravel these molecular details to allow us to differentiate cancer cells from normal cells and assess the usefulness of current and new cancer therapies. ..
  13. Mechanisms of Glioma Resistance to EGFR Inhibition
    JILL E WYKOSKY; Fiscal Year: 2012
    ..abstract_text> ..
  14. Biomolecular Analysis using Liquid Crystals
    Nicholas L Abbott; Fiscal Year: 2013
    ..public ..
  15. TOPOISOMERASE I INHIBITORS IN LEUKEMIA AND SOLID TUMORS
    Scott H Kaufmann; Fiscal Year: 2010
    ..Collectively, these studies are designed to provide new insight into the mechanism of action of topo I poisons, and identify strategies for enhancing their efficacy. ..
  16. IN VIVO CEREBRAL OXIDATIVE METABOLISM IN HYPOXIC NEWBORNS
    MARIA D DELIVORIA PAPADOPOULOS; Fiscal Year: 2010
    ..abstract_text> ..
  17. Markers of sensivity to the EGFR inhibitor erlotinib in breast cancer
    Naoto T Ueno; Fiscal Year: 2012
    ..Our findings will improve the outcome of cancer patients by increasing EGFR-TKI efficacy and facilitating the selection of patients who may benefit from EGFR-TKI therapy. ..
  18. Philip A Cole; Fiscal Year: 2016
    ..abstract_text> ..
  19. Phase I Clinical Trials of Anti-Cancer Agents
    Mark J Ratain; Fiscal Year: 2013
    ..The PAAR Group is part of a larger NIH Pharmacogenetics Research Network, administered through NIGMS. The applicants will also participate in the Investigational Drug Steering Committee and its Task Forces. ..
  20. TYROSINE KINASE INHIBITORS AS ANTINEOPLASTIC AGENTS
    Brian Druker; Fiscal Year: 2001
    ..This information would be useful for the design of more potent and specific ABL kinase inhibitors and would be helpful in the design of inhibitors of other tyrosine kinases. ..
  21. DEVELOPMENT OF CANCER IMAGING AGENTS
    Henry VanBrocklin; Fiscal Year: 2000
    ..Additionally, it will provide inroads into new areas of research in drug discovery and therapeutic intervention. ..
  22. Regulation of PTHrP in Squamous Cell Carcinoma by the EGF Receptor
    GWENDOLEN LORCH; Fiscal Year: 2010
    ..The results of the research will then be translated to advance the standard of human and animal cancer care worldwide. ..
  23. Evaluating Novel Multi-kinase Peptide Inhibitors as a Treatment for Rheumatoid Ar
    DAVID MEN HWEI TSAI; Fiscal Year: 2013
    ..The long term goal of this project is to develop a safe, effective, and cost-efficient therapy to treat RA. ..
  24. Gadiparthi N Rao; Fiscal Year: 2016
    ....
  25. GERTRUD M SCHUPBACH; Fiscal Year: 2016
    ..Our work identifies further genes that act in the same pathway as the receptor and these genes will provide new targets for specific cancer drugs as well as allowing us to address side effects of available cancer drugs. ..
  26. Fu Shin X Yu; Fiscal Year: 2016
    ....
  27. Robert L Ferris; Fiscal Year: 2014
    ..abstract_text> ..
  28. Polymorphism and mutation spectrum in minorities with non-small cell lung cancer
    David P Carbone; Fiscal Year: 2010
    ..The results should provide tremendous insight into the genomic factors which influence susceptibility, pathogenesis, drug sensitivity, and survival in African-Americans with non-small cell lung cancer. ..
  29. Jia Luo; Fiscal Year: 2016
    ..Understanding the interactions among alcohol, ErbB2 and MUC1 will also provide an important insight into the pathogenesis of some human diseases related to alcohol abuse as well as alcohol's teratogenic effect during development. ..
  30. Development of mutant selective EGFR kinase inhibitors against EGFR T790M
    John Chant; Fiscal Year: 2010
    ..Gatekeeper Therapeutics is developing drugs which might be very efficacious and might prolong the survival of a subset of lung cancer patients that are identified by the specific genetic mutations in their cancers. ..
  31. Steven M Dubinett; Fiscal Year: 2016
    ..Each year lung cancer exacts a devastating toll in terms of lives lost and resources expended. It is expected that this VA supported research will ultimately lead to improvement in disease-free survival for veterans with lung cancer. ..
  32. Role of PUMA in EGFR targeted therapy in HNSCC
    Jian Yu; Fiscal Year: 2012
    ..The results could be useful for developing improved strategies and agents for treatment of HNSCC and possibly other cancers with EGFR overexpression. ..
  33. Barry M Gumbiner; Fiscal Year: 2014
    ..Findings from these studies should reveal how contact inhibition regulates normal tissue development and how the loss of contact inhibition leads to the formation and progression of tumors. ..
  34. Role of EGFR in DNA Repair and Radiation Response in Non Small Cell Lung Cancer
    CHAITANYA SURESH NIRODI; Fiscal Year: 2012
    ..The long term goal is to develop a radiotherapeutic strategy that simulates the radiosensitizing effects of TKD-mutated EGFR in NSCLC patients. ..
  35. Trever G Bivona; Fiscal Year: 2016
    ..Our overall goal is to define the strategies for CD95-NF-kB inhibition most likely to be maximally effective in appropriately selected lung cancer patients. ! ..
  36. Pasi A Janne; Fiscal Year: 2016
    ..Findings from these studies have therapeutic implications for patients with cancers harboring genomic alterations in RET and catalyze the development of clinical trials for such patients. ..
  37. Regulation of EGFR Signaling by the Endocytic Pathway
    Brian P Ceresa; Fiscal Year: 2013
    ..The immediate goal of this research is to better understand the molecular mechanisms that regulate the biological and pathological functions of the EGFR and use that information for treatment of diseases associated with the EGFR. ..
  38. Daniel J Leahy; Fiscal Year: 2016
    ..These studies will establish a molecular basis for understanding of the physiological properties of these key receptors and illuminate new or optimal strategies to target their function in disease states. ..
  39. KATHERINE RENEE AMATO HASTINGS; Fiscal Year: 2014
    ..Combined, this proposal will enable investigation into the role of EphA2 in innate or acquired resistance to EGFR TKIs and highlight the utility of using EphA2 as a novel target for lung cancers currently refractory to treatment. ..
  40. Integrating cellular and molecular heterogeneity of TKI response in NSCLC cells
    PETER LEE FRICK; Fiscal Year: 2013
    ..This knowledge would help reconcile the promise of targeted therapies with the challenge of tumor heterogeneity, and could have high translational value. ..
  41. Jessica E Treisman; Fiscal Year: 2016
    ..Taken together, the proposal will reveal new molecular mechanisms in a conserved signaling pathway that is critical for retinal development. ..
  42. Genetic Analysis of EGFRvIII-independent Glioblastoma Maintenance
    TIFFANY ELIZABETH TAYLOR; Fiscal Year: 2013
    ....
  43. Receptor Tyrosine Kinase Signaling Networks
    Joannes B Hoek; Fiscal Year: 2010
    ....
  44. Regulation of Papillomavirus-Induced Immortalization by EGF-Receptor Inhibition
    CRAIG WOODWORTH; Fiscal Year: 2009
    ..Since drugs that inhibit this receptor have already been approved to treat lung and colorectal cancer, it is reasonable to test whether they also inhibit cervical carcinogenesis. ..
  45. HDGF: a novel biomarker and therapetic target of lung cancer
    Li Mao; Fiscal Year: 2012
    ..We will also evaluate our newly developed neutralizing monoclonal anti-HDGF antibodies for their utility as therapeutic agents in lung cancer treatment. ..
  46. Mizuki Nishino; Fiscal Year: 2015
    ..abstract_text> ..
  47. Trever G Bivona; Fiscal Year: 2014
    ..More broadly, these studies provide insight into the mechanisms by which tumor cells acquire oncogene dependence and escape from oncogene inhibition. ..
  48. ErbB Family in Pituitary Tumors
    Odelia Cooper; Fiscal Year: 2013
    ..We will test targeted therapy against this pathway to develop novel therapies in recurrent tumors. ..
  49. Nuclear EGFR Signaling Network in Human Cancer
    Hui Wen Lo; Fiscal Year: 2010
    ..Aim 3 will determine the significance and mechanisms for nuclear EGFR-mediated chemoresistance. This proposal is highly relevant to public health and its outcome will shed light into the nuclear EGFR signaling network in human cancers. ..
  50. Bruce E Johnson; Fiscal Year: 2016
    ..This will facilitate the development of more effective EGFR inhibitors either alone, or with other tyrosine kinase inhibitors and additional targeted agents. ..
  51. Advanced Anatomic and Functional Response Assessment in Lung Cancer
    Lawrence H Schwartz; Fiscal Year: 2011
    ..3. To determine if the use of a continuous scale best overall response better predicts than the categorical response assessment currently used. ..
  52. Dana-Farber/Harvard Cancer Center SPORE in Lung Cancer
    Bruce E Johnson; Fiscal Year: 2012
    ..The goal of the DF/HCC Lung Cancer SPORE is to continue the translation of biological and technological advances into clinically meaningful advances for patients with lung cancer and at risk for lung cancer. ..
  53. Bakhos A Tannous; Fiscal Year: 2014
    ..In this study, we will explore blood platelets as a source for detection of NSCLC predictive/responsive biomarkers. ..
  54. Ron Bose; Fiscal Year: 2016
    ..This information will identify new patients who are likely to benefit from Her2 targeted drugs and will provide the key scientific findings to support a future breast cancer clinical trial. ..
  55. KATE SUZANNE CARROLL; Fiscal Year: 2015
    ....
  56. Matthew L Meyerson; Fiscal Year: 2016
    ....
  57. Christine M Lovly; Fiscal Year: 2016
    ....
  58. IGF::OT::IGF SBIR TOPIC 255 cGMP Manufacture of
    FRANK R JONES; Fiscal Year: 2013
    ..Our goal is to complete the Aims of this contract and submit an IND to the FDA to initiate a phase l/lla clinical trial to treat HER2/neu+ breast cancer. ..
  59. Notch and stem cells in lung cancer treated with erlotinib plus notch inhibitor.
    DON LYNN GIBBONS; Fiscal Year: 2012
    ..While erlotinib is less effective vs EGFR wild type tumors, therapeutic benefit is nevertheless seen. ..
  60. PROTEIN PROTEIN INTERACTIONS AS BIOMARKERS
    Eric B Haura; Fiscal Year: 2012
    ..In Aim 4, we will determine if EGFR protein-protein interactions are associated with responses to EGFR tyrosine kinase inhibitors in human lung cancer samples. ..
  61. Konstantin V Sokolov; Fiscal Year: 2015
    ....
  62. Maria Diakonova; Fiscal Year: 2014
    ..Understanding how these proteins work together will help to design new therapeutic approaches and possibly drugs for treatment of different human diseases and breast cancer. ..
  63. Clifford A Lowell; Fiscal Year: 2016
    ..This will lead to better design of therapeutcs to target immune diseases, as well as leukemia and lymphoma. ..
  64. Agrin/alpha 3 Na,K-ATPase signaling at the neuromuscular junction
    Martin A Smith; Fiscal Year: 2012
    ..This novel signal pathway represents a new therapeutic target for the treatment of neuromuscular disease. ..
  65. Michael Demetriou; Fiscal Year: 2014
    ..Here we further explore the mechanisms by which protein glycosylation regulates immune function and autoimmunity. ..
  66. Moosa Mohammadi; Fiscal Year: 2016
    ..Since substrate recruitment and phosphorylation by RTKs is a general event in RTK signaling, the mechanistic insights gained under Aim IV will also be directly applicable to the entire RTK superfamily. ..
  67. Redox regulation of phagocyte NOX2 in inflammation and aging
    Robert A Clark; Fiscal Year: 2013
    ....
  68. GI PEPTIDE SIGNALING THROUGH TYROSINE PHOSPHORYLATION
    JUAN ENRIQUE ROZENGURT; Fiscal Year: 2010
    ....
  69. ANGIOTENSIN II SIGNAL TRANSDUCTION
    Bradford C Berk; Fiscal Year: 2012
    ..PUBLIC HEALTH RELEVANCE: The healing of tissues after surgery or trauma is critical for long-term survival. The proposed work will study novel mechanisms by which blood vessels grow in response to tissue injury. ..
  70. Mario Strazzabosco; Fiscal Year: 2016
    ....
  71. Mitchell Kronenberg; Fiscal Year: 2014
    ..This proposal will study the mechanisms by which the immune responses are properly controlled. Such knowledge will eventually facilitate the design of novel therapeutic approaches for immunological diseases. ..
  72. Genetic Analysis of FAK Activity
    David D Schlaepfer; Fiscal Year: 2012
    ..These studies will fill key gaps in our understanding of the basic signaling events regulating cell movement and underlying processes such as tumor spread. ..
  73. Subhash C Pandey; Fiscal Year: 2014
    ....
  74. Christie P Thomas; Fiscal Year: 2014
    ....
  75. Hesham M Amin; Fiscal Year: 2015
    ..Our long-term goal is to understand IGF-IR-dependent signaling in this aggressive lymphoma in order to devise novel therapeutic strategies. Tactics that antagonize IGF-IR could potentially provide a cure for NPM-ALK+ ALCL patients. ..
  76. Dianne Cox; Fiscal Year: 2014
    ....
  77. PROGESTIN AND GROWTH FACTOR CROSS-TALK IN BREAST CANCER
    CAROL ANN LANGE; Fiscal Year: 2010
    ..This work will aid our understanding of steroid hormone action, and help to identify and implicate new therapeutic targets for breast cancer prevention and treatment. ..
  78. C-FES PROTEIN-TYROSINE KINASE IN MYELOID DIFFERENTIATION
    Robert Glazer; Fiscal Year: 1993
    ..Cognizance of this regulatory process should aid in the design of differentiation- specific therapies for myeloid leukemias...
  79. Therapeutic Evaluation of Magnetic Nanoprobes Specific for Malignant Tumor Marker
    Rheal A Towner; Fiscal Year: 2010
    ..Studying a potentially effective anti- tumor therapeutic agent, as well as developing novel in vivo diagnostic and predictive procedures may significantly impact patient prognosis and survivability in the future. ..
  80. ADVANCED TECHNOLOGY FOR ASSAYING CANCER-DRUG RESISTANCE
    Mark Lim; Fiscal Year: 2010
    ..We will also maintain a close contact during Phase II with two leading diagnostic companies, LabCorp and Genzyme Genetics, who have expressed an interest in the ultimate commercialization of the DRAMA-ACD approach. ..
  81. DYSFUNCTIONAL FGFR SIGNALING IN CRANIOSYNOSTOSIS
    Robert Friesel; Fiscal Year: 2002
    ..Together, these studies should begin to elucidate the role of mutant FGFRs in the pathogenesis of craniosynostotic conditions, as well as the role of FGFRs in normal bone growth and development. ..
  82. Genome instability in leukemia stem cell
    Tomasz Skorski; Fiscal Year: 2010
    ..These studies will break ground toward new directions in studying LSCs in CML and other leukemias, and in testing of novel therapeutic strategies. ..