TRIM69

Summary

Gene Symbol: TRIM69
Description: tripartite motif containing 69
Alias: HSD-34, HSD34, RNF36, Trif, E3 ubiquitin-protein ligase TRIM69, RFP-like domain-containing protein trimless, RING-type E3 ubiquitin transferase TRIM69, ring finger protein 36
Species: human
Products:     TRIM69

Top Publications

  1. Huang H, Zeng Z, Wang K, Zhang H, Wang S, Zhou W, et al. Heme oxygenase-1 protects rat liver against warm ischemia/reperfusion injury via TLR2/TLR4-triggered signaling pathways. World J Gastroenterol. 2015;21:2937-48 pubmed publisher
    ..lysates were subjected to immunoprecipitation with anti-Toll-IL-1R-containing adaptor inducing interferon-β (TRIF) and anti-myeloid differentiation factor 88 (MyD88), and then the immunoprecipitates were analyzed by SDS-PAGE and ..
  2. Coleman O, Lobner E, Bierwirth S, Sorbie A, Waldschmitt N, Rath E, et al. Activated ATF6 Induces Intestinal Dysbiosis and Innate Immune Response to Promote Colorectal Tumorigenesis. Gastroenterology. 2018;: pubmed publisher
    ..in the myeloid differentiation primary response gene 88 and toll-like receptor adaptor molecule 1 gene (Myd88/TRIF-knockout mice)...
  3. Montazeri M, Sanchez Lopez J, Caballero I, Maslehat Lay N, Elliott S, López Martín S, et al. Activation of Toll-like receptor 3 reduces actin polymerization and adhesion molecule expression in endometrial cells, a potential mechanism for viral-induced implantation failure. Hum Reprod. 2015;30:893-905 pubmed publisher
    ..occur, inhibitors were applied for Toll/interleukin-1 receptor domain-containing adaptor inducing interferon-beta (TRIF), myeloid differentiation primary response 88 (MYD88), mitogen-activated protein kinases (MAPK) and nuclear factor ..
  4. Yao X, Wu J, Lin M, Sun W, He X, Gowda C, et al. Increased CD40 Expression Enhances Early STING-Mediated Type I Interferon Response and Host Survival in a Rodent Malaria Model. PLoS Pathog. 2016;12:e1005930 pubmed publisher
    ..in bone marrow derived dendritic cells/macrophages (BMDCs/BMDMs) and splenic DCs from CD40-/-, TLR3-/- TLR4-/-, TRIF-/-, and MyD88-/- mice after iRBC stimulation or parasite infection...
  5. Wong Baeza C, Tescucano A, Astudillo H, Reséndiz A, Landa C, España L, et al. Nonbilayer Phospholipid Arrangements Are Toll-Like Receptor-2/6 and TLR-4 Agonists and Trigger Inflammation in a Mouse Model Resembling Human Lupus. J Immunol Res. 2015;2015:369462 pubmed publisher
    ..C3a and C5a; they also had more TLR-4-expressing splenocytes, a higher expression of genes associated with TRIF-dependent TLR-4-signaling and complement activation, and a lower expression of apoptosis-related genes, compared to ..
  6. Li M, Li H, Fang F, Deng X, Ma S. Astragaloside IV attenuates cognitive impairments induced by transient cerebral ischemia and reperfusion in mice via anti-inflammatory mechanisms. Neurosci Lett. 2017;639:114-119 pubmed publisher
    ..primary response gene 88 (MyD88), toll/interleukin-1 receptor-domain containing adaptor-inducing interferon-? (TRIF) and tumour necrosis factor receptor associated factor-6 (TRAF6), and subsequently inhibited NF-?B phosphorylation...
  7. Kinsella S, Fichtner M, Watters O, König H, Prehn J. Increased A20-E3 ubiquitin ligase interactions in bid-deficient glia attenuate TLR3- and TLR4-induced inflammation. J Neuroinflammation. 2018;15:130 pubmed publisher
    ..We elucidated a positive role of Bid in both TIR-domain-containing adapter-inducing interferon-β (TRIF)- and myeloid differentiation primary response 88 (MyD88)-dependent pathways downstream of TLR4, concurrently ..
  8. Liu Y, Li T, Xu Y, Xu E, Zhou M, Wang B, et al. Effects of TLR4 gene silencing on the proliferation and apotosis of hepatocarcinoma HEPG2 cells. Oncol Lett. 2016;11:3054-3060 pubmed
    ..differentiation primary response 88 (MyD88), Toll-interleukin-1R-domain-containing adapter-inducing interferon-? (TRIF), interferon regulatory factor-3 (IRF3), nuclear factor (NF)-?B, NF-?B inhibitor ? (I?B?), phosphorylated I?B? (p-I?..
  9. Han J, Shim D, Shin W, Kim M, Shim E, Sun X, et al. Juniperus rigida Sieb. extract inhibits inflammatory responses via attenuation of TRIF-dependent signaling and inflammasome activation. J Ethnopharmacol. 2016;190:91-9 pubmed publisher
    ..7 cells. The inhibitory effects of JR were mediated through the regulation of the TRIF-dependent signaling pathway from JAK1/STAT1 phosphorylation...

More Information

Publications139 found, 100 shown here

  1. Wang G, Zhang M, Li Y, Zhou J, Chen L. Studying the Effect of Downregulating Autophagy-Related Gene LC3 on TLR3 Apoptotic Pathway Mediated by dsRNA in Hepatocellular Carcinoma Cells. Cancer Res Treat. 2017;49:230-245 pubmed publisher
    ..RNA (dsRNA) activated Toll-interleukin-1 receptor domain-containing adaptor inducing interferon β (TRIF) signal pathway in triggering apoptosis in hepatocellular carcinoma (HCC) cells...
  2. Huang N, Shaik Dasthagirisaheb Y, Lavalley M, Gibson F. Liver X receptors contribute to periodontal pathogen-elicited inflammation and oral bone loss. Mol Oral Microbiol. 2015;30:438-50 pubmed publisher
    ..gene 88 (MyD88)-independent, Toll/interleukin-1 receptor-domain-containing adapter-inducing interferon-β (TRIF)-dependent signaling affected P...
  3. Lötzerich M, Roulin P, Boucke K, Witte R, Georgiev O, Greber U. Rhinovirus 3C protease suppresses apoptosis and triggers caspase-independent cell death. Cell Death Dis. 2018;9:272 pubmed publisher
    ..RIPK1 binds to adaptor proteins, such as TRIF (Toll-IL-1 receptor-domain-containing-adaptor-inducing interferon-beta factor), FADD (Fas-associated-protein with ..
  4. Faria M, Calegari Silva T, de Carvalho Vivarini A, Mottram J, Lopes U, Lima A. Role of protein kinase R in the killing of Leishmania major by macrophages in response to neutrophil elastase and TLR4 via TNFα and IFNβ. FASEB J. 2014;28:3050-63 pubmed publisher
    ..isp2/isp3 grew normally in RAW-PKR-DN cells or macrophages from 129Sv pkr(-/-), tlr2(-/-), trif(-/-), and myd88(-/-) mice, associating NE activity, PKR, and TLR responses with parasite death...
  5. Hsieh L, Frey H, Nastase M, Tredup C, Hoffmann A, Poluzzi C, et al. Bimodal role of NADPH oxidases in the regulation of biglycan-triggered IL-1β synthesis. Matrix Biol. 2016;49:61-81 pubmed publisher
    ..Synthesis of NOX2 was mediated by adaptor molecule Toll/IL-1R domain-containing adaptor inducing IFN-β (TRIF)...
  6. Croker B, Crozat K, Berger M, Xia Y, Sovath S, Schaffer L, et al. ATP-sensitive potassium channels mediate survival during infection in mammals and insects. Nat Genet. 2007;39:1453-60 pubmed
    ..C) and immunostimulatory (CpG) DNA. The LPS hypersensitivity phenotype is not suppressed by mutations in Myd88, Trif, Tnf, Tnfrsf1a, Ifnb, Ifng or Stat1, genes contributing to LPS responses, and results from an abnormality extrinsic ..
  7. Agrawal V, Jaiswal M, Ilievski V, Beaman K, Jilling T, Hirsch E. Platelet-activating factor: a role in preterm delivery and an essential interaction with Toll-like receptor signaling in mice. Biol Reprod. 2014;91:119 pubmed publisher
    ..but not an alternative adaptor, Toll/IL-1 receptor domain-containing adapter protein-inducing interferon-beta (TRIF)...
  8. Yuan M, Xu Y, Chen L, Li X, Qin J, Shen Y. TLR3 expression correlates with apoptosis, proliferation and angiogenesis in hepatocellular carcinoma and predicts prognosis. BMC Cancer. 2015;15:245 pubmed publisher
    ..The expression and intracellular localization of TLR3 and downstream proteins (TRIF, NF-κB, and IRF3) were detected using immunohistochemistry...
  9. He Y, Xie Z, Dai J, Cao Y, Hou J, Zheng Y, et al. Responses of the Toll-like receptor and melanoma differentiation-associated protein 5 signaling pathways to avian infectious bronchitis virus infection in chicks. Virol Sin. 2016;31:57-68 pubmed publisher
    ..3 and TLR7 were upregulated at 3-8 dpi, and that of TIR-domain-containing adapter-inducing interferon (IFN) β (TRIF) was upregulated at 21 dpi in the trachea and kidney...
  10. Malada Edelstein Y, Hadad N, Levy R. Regulatory role of cytosolic phospholipase A2 alpha in the induction of CD40 in microglia. J Neuroinflammation. 2017;14:33 pubmed publisher
    ..The activation of cPLA2 by LPS was mediated by both adaptor proteins downstream to LPS receptor; TRIF and MyD88, while the activation of cPLA2? by IFN? was mediated by the secreted TNF-? at 4 h...
  11. Kang H, Kim I, Lee H, Joo H, Lim J, Lee J, et al. Chronic intermittent hypoxia induces liver fibrosis in mice with diet-induced obesity via TLR4/MyD88/MAPK/NF-kB signaling pathways. Biochem Biophys Res Commun. 2017;490:349-355 pubmed publisher
    ..oxidative stress markers, TLR4, MyD88, Toll/interleukin-1-receptor-domain-containing adaptor-inducing interferon-? (TRIF), I-?B, NF-?B, p38 MAPK, c-JNK, and ERK activation, were measured in the serum and liver...
  12. Smith H, Liu X, Dai L, Goh E, Chan A, Xi J, et al. The role of TBK1 and IKKε in the expression and activation of Pellino 1. Biochem J. 2011;434:537-48 pubmed publisher
    ..This induction occurs via a TRIF [TIR (Toll/interleukin-1 receptor)-domain-containing adaptor-inducing interferon-β]-dependent IRAK-independent ..
  13. Lee Y, Kim Y, Jung Y, Kim K, Kim D, Na S, et al. Hepatocyte toll-like receptor 4 mediates lipopolysaccharide-induced hepcidin expression. Exp Mol Med. 2017;49:e408 pubmed publisher
    ..in TLR4, myeloid differentiation factor 88 (MyD88) and TIR domain-containing adaptor inducing interferon-? (TRIF), we demonstrated that LPS-induced hepcidin expression by hepatocytes is regulated by its specific receptor, TLR4, ..
  14. Zettel K, Korff S, Zamora R, Morelli A, Darwiche S, Loughran P, et al. Toll-Like Receptor 4 on both Myeloid Cells and Dendritic Cells Is Required for Systemic Inflammation and Organ Damage after Hemorrhagic Shock with Tissue Trauma in Mice. Front Immunol. 2017;8:1672 pubmed publisher
    ..The role of TLR4 was determined using TLR4-/-, MyD88-/-, and Trif-/- C57BL/6 (B6) mice, and by in vivo administration of a TLR4-specific neutralizing monoclonal ..
  15. Jang A, Choi J, Shin S, Park J. Mycobacterium tuberculosis ESAT6 induces IFN-β gene expression in Macrophages via TLRs-mediated signaling. Cytokine. 2018;104:104-109 pubmed publisher
    ..Deficiency of TLR4 and TRIF absolutely abrogated ESAT6-induced IFN-β gene expression...
  16. Phongsisay V. The immunobiology of Campylobacter jejuni: Innate immunity and autoimmune diseases. Immunobiology. 2016;221:535-43 pubmed publisher
    ..Furthermore, C. jejuni targets MyD88, NLRP3 inflammasome, TIR-domain-containing adapter-inducing interferon-β (TRIF), sialic acid-binding immunoglobulin-like lectins (Siglecs), macrophage galactose-type lectin (MGL), and ..
  17. Kleinman M, Yamada K, Takeda A, Chandrasekaran V, Nozaki M, Baffi J, et al. Sequence- and target-independent angiogenesis suppression by siRNA via TLR3. Nature. 2008;452:591-7 pubmed publisher
    ..targeted (against Vegfa or Vegfr1) siRNA suppressed CNV via cell-surface toll-like receptor 3 (TLR3), its adaptor TRIF, and induction of interferon-gamma and interleukin-12...
  18. Andersen B, Xia J, Epstein A, Ohlfest J, Chen W, Blazar B, et al. Monomeric annexin A2 is an oxygen-regulated toll-like receptor 2 ligand and adjuvant. J Immunother Cancer. 2016;4:11 pubmed publisher
    ..heterotetramer signals human and murine macrophages to produce IL-1, IL-6, and TNF-α through TLR4/MyD88- and TRIF-dependent pathways. GL261 glioma cells were cultured in 5 % or 20 % O2...
  19. Mallama C, McCoy Simandle K, Cianciotto N. The Type II Secretion System of Legionella pneumophila Dampens the MyD88 and Toll-Like Receptor 2 Signaling Pathway in Infected Human Macrophages. Infect Immun. 2017;85: pubmed publisher
    ..RNA (dsRNA)-dependent protein kinase receptor (PKR), or TIR domain-containing adaptor inducing interferon beta (TRIF) signaling or an apoptosis-associated speck-like protein containing a CARD (ASC)- or caspase-4-dependent ..
  20. Ueda H, Maeda S. [Prothymosin?, as a neuroprotective DAMPs/Alarmins molecule]. Nihon Yakurigaku Zasshi. 2018;151:15-19 pubmed publisher
    ..ischemia model, ProT? prevents the damages by another mechanism through toll-like receptor 4 (TLR4) and downstream TRIF signaling...
  21. Li B, Fang J, Zuo Z, Yin S, He T, Yang M, et al. Activation of Porcine Alveolar Macrophages by Actinobacillus pleuropneumoniae Lipopolysaccharide via the Toll-Like Receptor 4/NF-?B-Mediated Pathway. Infect Immun. 2018;86: pubmed publisher
    ..pleuropneumoniae LPS, resulting in upregulation of signaling molecules, including TLR4, MyD88, TRIF-related adaptor molecule, and NF-?B. In contrast, the activation effects of A...
  22. Jafari R, Aflatoonian R, Falak R, Pourmand G, Dehghani S, Mortazavi M, et al. Down-regulation of inflammatory signaling pathways despite up-regulation of Toll-like receptors; the effects of corticosteroid therapy in brain-dead kidney donors, a double-blind, randomized, controlled trial. Mol Immunol. 2018;94:36-44 pubmed publisher
    ..Gene expression for Toll-like receptors (TLRs) 1-9 and their signaling pathway molecules including MYD88, TRIF, NF-KB1, IRAK, IRF3, and IRF7, as well as the inflammatory cytokines RANTES, IL-1β, TNF-α, IL-6, CXCL8, IL-18, ..
  23. Bomfim G, Echem C, Martins C, Costa T, Sartoretto S, dos Santos R, et al. Toll-like receptor 4 inhibition reduces vascular inflammation in spontaneously hypertensive rats. Life Sci. 2015;122:1-7 pubmed publisher
    ..Mesenteric arteries from SHR treated with anti-TLR4 displayed decreased expression of MyD88, but not TRIF, key molecules in TLR4 signaling...
  24. Zhang Y, Shan P, Srivastava A, Jiang G, Zhang X, Lee P. An Endothelial Hsp70-TLR4 Axis Limits Nox3 Expression and Protects Against Oxidant Injury in Lungs. Antioxid Redox Signal. 2016;24:991-1012 pubmed publisher
    ..We identified that Nox3 is regulated by heat shock protein 70 (Hsp70) signaling via a TLR4-Trif-signal transducer and activator of transcription 3 (Stat3) pathway and that Nox3 induction leads to increased ..
  25. Li J, Sasaki G, Dey P, Chitchumroonchokchai C, Labyk A, McDonald J, et al. Green tea extract protects against hepatic NFκB activation along the gut-liver axis in diet-induced obese mice with nonalcoholic steatohepatitis by reducing endotoxin and TLR4/MyD88 signaling. J Nutr Biochem. 2018;53:58-65 pubmed publisher
    ..0 or 2% for 8 weeks before assessing NASH, NFκB-mediated inflammation, TLR4 and its adaptor proteins MyD88 and TRIF, circulating endotoxin, and intestinal tight junction protein mRNA expression. TLR4m mice had lower (P<...
  26. Reino D, Pisarenko V, Palange D, Doucet D, Bonitz R, Lu Q, et al. Trauma hemorrhagic shock-induced lung injury involves a gut-lymph-induced TLR4 pathway in mice. PLoS ONE. 2011;6:e14829 pubmed publisher
    ..b>TRIF and Myd88 deficiency fully and partially attenuated T/HS lymph-induced increases in lung permeability respectively...
  27. Yang M, Wang C, Zhu X, Tang S, Shi L, Cao X, et al. E3 ubiquitin ligase CHIP facilitates Toll-like receptor signaling by recruiting and polyubiquitinating Src and atypical PKC{zeta}. J Exp Med. 2011;208:2099-112 pubmed publisher
    ..These findings suggest that CHIP facilitates the formation of a TLR signaling complex by recruiting, ubiquitinating, and activating Src and PKC?. ..
  28. Xia X, Fu J, Song X, Shi Q, Su C, Song E, et al. Neohesperidin dihydrochalcone down-regulates MyD88-dependent and -independent signaling by inhibiting endotoxin-induced trafficking of TLR4 to lipid rafts. Free Radic Biol Med. 2015;89:522-32 pubmed publisher
    ..that NHDC inhibited LPS-induced myeloid differentiation factor 88 (MyD88) and TIR-containing adapter molecule (TRIF)-dependent signaling. Transient transfection of TLR4 or MyD88 siRNA inhibited the downstream inflammatory signaling...
  29. Cano A, Mattana A, Woods S, Henriquez F, Alexander J, Roberts C. Acanthamoeba Activates Macrophages Predominantly through Toll-Like Receptor 4- and MyD88-Dependent Mechanisms To Induce Interleukin-12 (IL-12) and IL-6. Infect Immun. 2017;85: pubmed publisher
    ..The utilization of macrophages derived from MyD88-, TRIF-, Toll-like receptor 2 (TLR2)-, TLR4-, and TLR2/4-deficient mice indicated that Acanthamoeba-induced ..
  30. Muralidharan S, Lim A, Catalano D, Mandrekar P. Human Binge Alcohol Intake Inhibits TLR4-MyD88 and TLR4-TRIF Responses but Not the TLR3-TRIF Pathway: HspA1A and PP1 Play Selective Regulatory Roles. J Immunol. 2018;200:2291-2303 pubmed publisher
    Binge/moderate alcohol suppresses TLR4-MyD88 proinflammatory cytokines; however, alcohol's effects on TLR-TRIF signaling, especially after in vivo exposure in humans, are unclear...
  31. Nasim F, Ejaz S, Ashraf M, Ahmad G. Indirect Back-Titration ELISA: A New Format for Estimation of Human Tissue Kallikreins. Appl Immunohistochem Mol Morphol. 2016;24:64-70 pubmed publisher
    ..human tissue kallikreins we have now developed an indirect, back-titration style, Time Resolved ImmunoFluorometric (TRIF) ELISA that uses only 1 antigen-specific moAB and a general polyclonal antibody...
  32. Junkin M, Kaestli A, Cheng Z, Jordi C, Albayrak C, Hoffmann A, et al. High-Content Quantification of Single-Cell Immune Dynamics. Cell Rep. 2016;15:411-22 pubmed publisher
    ..Computational modeling of the LPS/TLR4 pathway shows that post-transcriptional regulation by TRIF is a key determinant of noisy and uncorrelated TNF secretion dynamics in single macrophages.
  33. Li H, Liu J, Zhang S, Luo T, Wu F, Dong J, et al. Corilagin ameliorates the extreme inflammatory status in sepsis through TLR4 signaling pathways. BMC Complement Altern Med. 2017;17:18 pubmed publisher
    ..Real-time PCR and western blot were employed to detect the mRNA and protein expressions of TLR4, MyD88, TRIF and TRAF6. ELISA was used to determine the IL-6 and IL-1? levels in supernatant and serum...
  34. James K, Soon M, Sebina I, Fernández Ruiz D, Davey G, Liligeto U, et al. IFN Regulatory Factor 3 Balances Th1 and T Follicular Helper Immunity during Nonlethal Blood-Stage Plasmodium Infection. J Immunol. 2018;200:1443-1456 pubmed publisher
    ..stimulator of IFN genes, or mitochondrial antiviral-signaling protein, and only modest roles for MyD88 and TRIF-dependent signaling in controlling PbTII cell expansion...
  35. Hosmane S, Tegenge M, Rajbhandari L, Uapinyoying P, Ganesh Kumar N, Thakor N, et al. Toll/interleukin-1 receptor domain-containing adapter inducing interferon-β mediates microglial phagocytosis of degenerating axons. J Neurosci. 2012;32:7745-57 pubmed publisher
    ..and genetic disruption of Toll/interleukin-1 receptor domain-containing adapter inducing interferon-β (TRIF), a Toll-like receptor adapter protein, blocks induction of the interferon response and inhibits microglial ..
  36. Emmerich C, Bakshi S, Kelsall I, Ortiz Guerrero J, Shpiro N, Cohen P. Lys63/Met1-hybrid ubiquitin chains are commonly formed during the activation of innate immune signalling. Biochem Biophys Res Commun. 2016;474:452-461 pubmed publisher
    ..Here we show that Lys63/Met1-Ub hybrids are also formed rapidly when the TNFR1/TRADD, TLR3/TRIF- and NOD1/RIP2-signaling networks are activated, some of which are attached covalently to Receptor-Interacting ..
  37. Brunn A, Mihelcic M, Carstov M, Feind L, Wieser E, Schmidt J, et al. Toll-Like Receptor 2, Toll-Like Receptor 4, Myeloid Differentiation Response Gene 88, and Toll-IL-1 Receptor Domain-Containing Adaptor-Inducing Interferon-? (TRIF) Selectively Regulate Susceptibility of P0106-125-Induced Murine Experimental Autoimmun. Am J Pathol. 2017;187:42-54 pubmed publisher
    ..myeloid differentiation response gene 88, and Toll-IL-1 receptor domain-containing adaptor-inducing interferon-? (TRIF), factors critically involved in the TLR signaling pathway, was studied in experimental autoimmune neuritis...
  38. Shi J, Li Q, Sheng M, Zheng M, Yu M, Zhang L. The Role of TLR4 in M1 Macrophage-Induced Epithelial-Mesenchymal Transition of Peritoneal Mesothelial Cells. Cell Physiol Biochem. 2016;40:1538-1548 pubmed publisher
    ..found TLR4 surface receptors were activated on sorted M1 cells in co-culture, and related signal adaptors, such as TRIF, were obviously upregulated...
  39. Popovic Z, Embgenbroich M, Chessa F, Nordström V, Bonrouhi M, Hielscher T, et al. Hyperosmolarity impedes the cross-priming competence of dendritic cells in a TRIF-dependent manner. Sci Rep. 2017;7:311 pubmed publisher
    ..We identified TRIF as key mediator of this phenomenon...
  40. Bugge M, Bergstrom B, Eide O, Solli H, Kjønstad I, Stenvik J, et al. Surface Toll-like receptor 3 expression in metastatic intestinal epithelial cells induces inflammatory cytokine production and promotes invasiveness. J Biol Chem. 2017;292:15408-15425 pubmed publisher
    ..This stimulation leads to recruitment of the adaptor molecule TRIF (Toll/IL-1 resistance (TIR) domain-containing adapter-inducing interferon ?) and activation of the transcription ..
  41. Srivastava N, Shelly A, Kumar M, Pant A, Das B, Majumdar T, et al. Aeromonas hydrophila utilizes TLR4 topology for synchronous activation of MyD88 and TRIF to orchestrate anti-inflammatory responses in zebrafish. Cell Death Discov. 2017;3:17067 pubmed publisher
    ..It transduces signals through two distinct TIR-domain-containing adaptors, MyD88 and TRIF, which function at the plasma membrane and endosomes, respectively...
  42. Yurchenko M, Skjesol A, Ryan L, Richard G, Kandasamy R, Wang N, et al. SLAMF1 is required for TLR4-mediated TRAM-TRIF-dependent signaling in human macrophages. J Cell Biol. 2018;217:1411-1429 pubmed publisher
    ..Interestingly, the SLAMF1-TRAM interaction was observed for human but not mouse proteins. Overall, our observations suggest that SLAMF1 is a new target for modulation of TLR4-TRAM-TRIF inflammatory signaling in human cells.
  43. Agudo J, Ruzo A, Kitur K, Sachidanandam R, Blander J, Brown B. A TLR and non-TLR mediated innate response to lentiviruses restricts hepatocyte entry and can be ameliorated by pharmacological blockade. Mol Ther. 2012;20:2257-67 pubmed publisher
    ..We examined the response to LV in MyD88-TRIF knockout mice, which are incapable of toll-like receptor (TLR) signaling...
  44. van Lieshout M, Florquin S, Vanʼt Veer C, de Vos A, van der Poll T. TIR-Domain-Containing Adaptor-Inducing Interferon-β (TRIF) Mediates Antibacterial Defense during Gram-Negative Pneumonia by Inducing Interferon-x03B3. J Innate Immun. 2015;7:637-46 pubmed publisher
    ..Mice deficient for TIR-domain-containing adaptor-inducing interferon-β (TRIF) demonstrate enhanced bacterial growth and dissemination during Klebsiella pneumonia...
  45. Funami K, Matsumoto M, Enokizono Y, Ishii N, Tatematsu M, Oshiumi H, et al. Identification of a Regulatory Acidic Motif as the Determinant of Membrane Localization of TICAM-2. J Immunol. 2015;195:4456-65 pubmed publisher
    ..the adaptors Toll/IL-1R domain-containing adaptor molecule (TICAM)-2 (also called TRAM) and TICAM-1 (also called TRIF), together with Toll/IL-1R domain-containing adaptor protein (TIRAP) and MyD88...
  46. Wang C, Ji L, Yuan X, Jin Y, Cardona C, Xing Z. Differential Regulation of TLR Signaling on the Induction of Antiviral Interferons in Human Intestinal Epithelial Cells Infected with Enterovirus 71. PLoS ONE. 2016;11:e0152177 pubmed publisher
    ..In this study we report that in EV71-infected HT-29 cells, TLR/TRIF signaling was essential to IFN induction; viral replication increased and the induction of IFN-α, -β, -ω, ..
  47. Zhan Q, Song R, Li F, Ao L, Zeng Q, Xu D, et al. Double-stranded RNA upregulates the expression of inflammatory mediators in human aortic valve cells through the TLR3-TRIF-noncanonical NF-κB pathway. Am J Physiol Cell Physiol. 2017;312:C407-C417 pubmed publisher
    ..Knockdown of Toll-like receptor 3 (TLR3) or Toll-IL-1 receptor domain-containing adapter-inducing IFN-β (TRIF) suppressed ERK1/2 and NF-κB p65 phosphorylation and reduced inflammatory mediator production induced by poly(I:..
  48. Murphy M, Xiong Y, Pattabiraman G, Qiu F, Medvedev A. Pellino-1 Positively Regulates Toll-like Receptor (TLR) 2 and TLR4 Signaling and Is Suppressed upon Induction of Endotoxin Tolerance. J Biol Chem. 2015;290:19218-32 pubmed publisher
    ..differentiation primary response protein (MyD88), and Toll-IL-1R domain-containing adapter inducing IFN-β (TRIF)-dependent cytokine genes in response to TLR4 and TLR2 agonists and heat-killed Escherichia coli and Staphylococcus ..
  49. Singh M, Cicha M, Meyerholz D, Chapleau M, Abboud F. Dual Activation of TRIF and MyD88 Adaptor Proteins by Angiotensin II Evokes Opposing Effects on Pressure, Cardiac Hypertrophy, and Inflammatory Gene Expression. Hypertension. 2015;66:647-56 pubmed publisher
    ..protein 88 (MyD88) and toll-interleukin receptor domain-containing adaptor protein-inducing interferon-β (TRIF) define 2 major inflammatory pathways...
  50. Feng Y, Gao J, Cui Y, Li M, Li R, Cui C, et al. Neuroprotective Effects of Resatorvid Against Traumatic Brain Injury in Rat: Involvement of Neuronal Autophagy and TLR4 Signaling Pathway. Cell Mol Neurobiol. 2017;37:155-168 pubmed publisher
    ..In addition, the expression of TLR4 downstream signaling molecules, including MyD88, TRIF, NF-κB, TNF-α, and IL-1β, was significantly downregulated in hippocampus tissue by Western blot analysis...
  51. Wang X, Majumdar T, Kessler P, Ozhegov E, Zhang Y, Chattopadhyay S, et al. STING Requires the Adaptor TRIF to Trigger Innate Immune Responses to Microbial Infection. Cell Host Microbe. 2016;20:329-341 pubmed publisher
    ..The TIR-domain containing protein TRIF is the sole adaptor of TLR3...
  52. Gall B, Pryke K, Abraham J, Mizuno N, Botto S, Sali T, et al. Emerging Alphaviruses Are Sensitive to Cellular States Induced by a Novel Small-Molecule Agonist of the STING Pathway. J Virol. 2018;92: pubmed publisher
    ..type I IFN response in a manner that requires the adaptor protein STING but not the alternative adaptors MAVS and TRIF. Importantly, treatment of cells with C11 generated a cellular state that potently blocked replication of multiple ..
  53. Wu Y, Ren D, Chen G. Siglec-E Negatively Regulates the Activation of TLR4 by Controlling Its Endocytosis. J Immunol. 2016;197:3336-3347 pubmed
    ..as a result of the inability to internalize TLR4, Siglec-E-deficient dendritic cells were also defective for TRIF-mediated IFN-? production in response to E. coli infection...
  54. Zhang X, Hu Y, Justice A, Li B, Wang Z, Zhao H, et al. DNA methylation signatures of illicit drug injection and hepatitis C are associated with HIV frailty. Nat Commun. 2017;8:2243 pubmed publisher
    ..We observe 6 significant CpGs in the promoters of 4 genes, NLRC5, TRIM69, CX3CR1, and BCL9, in the discovery sample and in meta-analysis...
  55. Huang B, Park D, Baek S. TRIF is a regulator of TLR2-induced foam cell formation. Mol Med Rep. 2016;14:3329-35 pubmed publisher
    ..In the present study, the role of toll/interleukin-1 receptor-domain-containing adaptor-inducing interferon-? (TRIF) in TLR2-mediated foam cell formation was investigated, and the importance of monocyte chemoattractant protein?1 (..
  56. Zou H, Su R, Ruan J, Shao H, Qian K, Ye J, et al. Double-stranded RNA induces chicken T-cell lymphoma apoptosis by TRIF and NF-?B. Sci Rep. 2017;7:7547 pubmed publisher
    ..that an interferon-independent mechanism involving Toll-IL-1-receptor domain-containing adapter-inducing IFN-? (TRIF) and nuclear factor ?B (NF-?B) causes the apoptosis of MDCC-MSB1 cells...
  57. Fields C, Chassaing B, Castillo Ruiz A, Osan R, Gewirtz A, De Vries G. Effects of gut-derived endotoxin on anxiety-like and repetitive behaviors in male and female mice. Biol Sex Differ. 2018;9:7 pubmed publisher
    ..However, treatment with (+)-naloxone, which blocks the TRIF pathway of TLR4, had opposing behavioral effects in males and females (independent of LPS treatment)...
  58. Lehr S, Vier J, Hacker G, Kirschnek S. Activation of neutrophils by Chlamydia trachomatis-infected epithelial cells is modulated by the chlamydial plasmid. Microbes Infect. 2018;20:284-292 pubmed publisher
    ..A second, neutrophil TNF-stimulatory activity was detected in supernatants, requiring MyD88 or TRIF independently of the plasmid...
  59. Tohmé M, Manoury B. Invariant chain is a new chaperone for TLR7 in B cells. Mol Immunol. 2015;68:102-5 pubmed publisher
    ..they relocate to the endo-lysosomal compartment, allowing the recruitment of the adaptor molecules, MyD88 or TRIF. Increasing evidences describe a cross talk between proteins that regulate both innate and adaptive immune ..
  60. Burrows M, Volchkov P, Kobayashi K, Chervonsky A. Microbiota regulates type 1 diabetes through Toll-like receptors. Proc Natl Acad Sci U S A. 2015;112:9973-7 pubmed publisher
    ..Only MyD88- and TIR-domain containing adapter inducing IFN β (TRIF) double deficient NOD mice developed the disease...
  61. Ahn S, Kim J, Gu G, Shin H, Kim A, Shim H, et al. Suppression of Toll-Like Receptor 4 Dimerization by 1-[5-Methoxy-2-(2-nitrovinyl)phenyl]pyrrolidine. Arch Pharm (Weinheim). 2016;349:785-790 pubmed publisher
    ..factor 88 (MyD88) and the Toll/interleukin-1 receptor domain-containing adapter, inducing interferon-? (TRIF)-dependent major downstream signaling pathways...
  62. Brempelis K, Yuen S, Schwarz N, Mohar I, Crispe I. Central role of the TIR-domain-containing adaptor-inducing interferon-β (TRIF) adaptor protein in murine sterile liver injury. Hepatology. 2017;65:1336-1351 pubmed publisher
    ..In this model, the TIR-domain-containing adaptor-inducing interferon-β (TRIF) was a central mediator of the resulting intrahepatic inflammatory response that was independent of both upstream ..
  63. Liu W, Ge M, Hu X, Lv A, Ma D, Huang X, et al. The Effects of Agaricus blazei Murill Polysaccharides on Cadmium-Induced Apoptosis and the TLR4 Signaling Pathway of Peripheral Blood Lymphocytes in Chicken. Biol Trace Elem Res. 2017;180:153-163 pubmed publisher
    ..genes (caspase-3, Bax, and Bcl-2), the mRNA levels of TLR4 and TLR4 signaling pathway-related factors (MyD88, TRIF, NF-?B, and IRF3), the TLR4 protein expression, and the concentrations of inflammatory cytokines (IL-1?, IL-6, and ..
  64. Fitzgerald K, Rowe D, Barnes B, Caffrey D, Visintin A, Latz E, et al. LPS-TLR4 signaling to IRF-3/7 and NF-kappaB involves the toll adapters TRAM and TRIF. J Exp Med. 2003;198:1043-55 pubmed
    Toll-IL-1-resistance (TIR) domain-containing adaptor-inducing IFN-beta (TRIF)-related adaptor molecule (TRAM) is the fourth TIR domain-containing adaptor protein to be described that participates in Toll receptor signaling...
  65. Rodriguez Miguelez P, Fernandez Gonzalo R, Collado P, Almar M, Martínez Flórez S, de Paz J, et al. Whole-body vibration improves the anti-inflammatory status in elderly subjects through toll-like receptor 2 and 4 signaling pathways. Mech Ageing Dev. 2015;150:12-9 pubmed publisher
    ..myeloid differentiation primary response gen 88 (MyD88) and TIR domain-containing adaptor inducing interferon (TRIF)-dependent pathways were analyzed. Plasma TNFα and C-reactive protein levels were also assessed...
  66. Dauletbaev N, Cammisano M, Herscovitch K, Lands L. Stimulation of the RIG-I/MAVS Pathway by Polyinosinic:Polycytidylic Acid Upregulates IFN-β in Airway Epithelial Cells with Minimal Costimulation of IL-8. J Immunol. 2015;195:2829-41 pubmed publisher
    ..submerged and well-differentiated), we observed that pure poly(I:C) stimulated IFN-β mainly through the TLR3/TRIF pathway and IL-8 through an unidentified pathway...
  67. Owen K, Anderson C, Casanova J. Salmonella Suppresses the TRIF-Dependent Type I Interferon Response in Macrophages. MBio. 2016;7:e02051-15 pubmed publisher
    ..xenophagy), but not autophagy alone, triggers IFN-β production through a pathway involving the adapter TRIF and endosomal Toll-like receptor 3 (TLR3) and TLR4...
  68. Peterson L, Philip N, Dillon C, Bertin J, Gough P, Green D, et al. Cell-Extrinsic TNF Collaborates with TRIF Signaling To Promote Yersinia-Induced Apoptosis. J Immunol. 2016;197:4110-4117 pubmed
    ..This cell death requires RIPK1 kinase activity and caspase-8, which are engaged by TLR4 and the adaptor protein TRIF. Nevertheless, TLR4- and TRIF-deficient cells undergo significant apoptosis, implicating TLR4/TRIF-independent ..
  69. Ding Z, An K, Xie L, Wu W, Zhang R, Wang D, et al. Transmissible gastroenteritis virus infection induces NF-?B activation through RLR-mediated signaling. Virology. 2017;507:170-178 pubmed publisher
    ..while only slight reduction was observed in cells following silencing of Toll-like receptor adaptors, MyD88 and TRIF. Furthermore, TGEV infection significantly upregulated mRNA expression of RIG-I and MDA5...
  70. Xu P, Sun Z, Wang Y, Miao C. Long-term use of indomethacin leads to poor prognoses through promoting the expression of PD-1 and PD-L2 via TRIF/NF-κB pathway and JAK/STAT3 pathway to inhibit TNF-α and IFN-γ in hepatocellular carcinoma. Exp Cell Res. 2015;337:53-60 pubmed publisher
    ..In addition, long-term use of indomethacin activates TRIF/NF-κB and JAK/STAT3 pathways, and indomethacin promotes the expression of PD-1 and PD-L2 via TRIF/NF-κB ..
  71. Knobloch J, Chikosi S, Yanik S, Rupp J, Jungck D, Koch A. A systemic defect in Toll-like receptor 4 signaling increases lipopolysaccharide-induced suppression of IL-2-dependent T-cell proliferation in COPD. Am J Physiol Lung Cell Mol Physiol. 2016;310:L24-39 pubmed publisher
    ..Bacterial endotoxin (LPS) activates MyD88/IRAK and TRIF/IKKε/TBK1 pathways via Toll-like receptor-4 (TLR4) in Th1 cells...
  72. Zhang H, Rodriguez S, Wang L, Wang S, Serezani H, Kapur R, et al. Sepsis Induces Hematopoietic Stem Cell Exhaustion and Myelosuppression through Distinct Contributions of TRIF and MYD88. Stem Cell Reports. 2016;6:940-956 pubmed publisher
    ..Using mice deficient in TLR4 downstream adapters MYD88 or TRIF, we demonstrate that both cell-autonomous and non-cell-autonomous MYD88 activation are major causes of ..
  73. Tsai W, Cheng J, Shu C, Lai K, Chan H, Wu C, et al. Asunaprevir Evokes Hepatocytes Innate Immunity to Restrict the Replication of Hepatitis C and Dengue Virus. Front Microbiol. 2017;8:668 pubmed publisher
    ..siRNA-mediated MAVS and TRIF knockdown of cells was performed to assess the effect of asunaprevir-regulated innate immunity against HCV and DENV...
  74. Jayaraman P, Devlin A, Miller J, Scholle F. The adaptor molecule Trif contributes to murine host defense during Leptospiral infection. Immunobiology. 2016;221:964-74 pubmed publisher
    ..interrogans; however, the role of the TLR adaptor molecule TIR-domain-containing adaptor-inducing interferon ? (TRIF) in the response to L. interrogans has not been previously determined...
  75. Moroishi T, Hayashi T, Pan W, Fujita Y, Holt M, Qin J, et al. The Hippo Pathway Kinases LATS1/2 Suppress Cancer Immunity. Cell. 2016;167:1525-1539.e17 pubmed publisher
    ..extracellular vesicles, which induce a type I interferon response via the Toll-like receptors-MYD88/TRIF pathway...
  76. Hernandez A, Bohannon J, Luan L, Fensterheim B, Guo Y, Patil N, et al. The role of MyD88- and TRIF-dependent signaling in monophosphoryl lipid A-induced expansion and recruitment of innate immunocytes. J Leukoc Biol. 2016;100:1311-1322 pubmed
    ..This study examined the importance of MyD88- and TRIF-dependent signaling for leukocyte mobilization, recruitment, and activation following administration of MPLA...
  77. Feng Y, Zou L, Yan D, Chen H, Xu G, Jian W, et al. Extracellular MicroRNAs Induce Potent Innate Immune Responses via TLR7/MyD88-Dependent Mechanisms. J Immunol. 2017;199:2106-2117 pubmed publisher
    ..was abolished in cells deficient of TLR7 or MyD88, or by a TLR7 antagonist, but remained the same in TLR3- or Trif-deficient cells. In vivo, mice i.p...
  78. Liu T, Hu X, Wang Y, Meng L, Zhou Y, Zhang J, et al. Triazine-based covalent organic frameworks for photodynamic inactivation of bacteria as type-II photosensitizers. J Photochem Photobiol B. 2017;175:156-162 pubmed publisher
    ..Herein, we reported two covalent organic frameworks (COFs) materials, namely COFs-Trif-Benz and COF-SDU1, as effective type-II photosensitizers for photodynamic inactivation of bacteria...
  79. Chang M, Kang I, Gale M, MANICONE A, Kinsella M, Braun K, et al. Versican is produced by Trif- and type I interferon-dependent signaling in macrophages and contributes to fine control of innate immunity in lungs. Am J Physiol Lung Cell Mol Physiol. 2017;313:L1069-L1086 pubmed publisher
    ..that LPS and polyinosinic-polycytidylic acid [poly(I:C)] trigger a signaling cascade involving TLR3 or TLR4, the Trif adaptor, type I interferons, and IFNAR1, leading to increased expression of versican by macrophages and implicating ..
  80. Liu G, Zhang Y, Zhang N, Ni W, Jie J, Jiang L, et al. Escherichia coli maltose-binding protein (MBP) activates mouse Th1 through TLR2-mediated MyD88-dependent pathway and TLR4-mediated TRIF-dependent pathway. Int Immunopharmacol. 2017;50:338-344 pubmed publisher
    ..We found that MBP increased the mRNA levels of MyD88, TRAF6, TRIF and TRAF3 expressed in CD4+T cells...
  81. Kuzmich N, Sivak K, Chubarev V, Porozov Y, Savateeva Lyubimova T, Peri F. TLR4 Signaling Pathway Modulators as Potential Therapeutics in Inflammation and Sepsis. Vaccines (Basel). 2017;5: pubmed publisher
    ..molecules at a preclinical or clinical phase of development, that are active in inhibiting the TLR4-MyD88 and TLR4-TRIF pathways in animal models...
  82. Zenke K, Muroi M, Tanamoto K. AKT1 distinctively suppresses MyD88-depenedent and TRIF-dependent Toll-like receptor signaling in a kinase activity-independent manner. Cell Signal. 2018;43:32-39 pubmed publisher
    ..Toll-like receptor (TLR)-mediated MyD88-dependent and Toll/IL-1R domain-containing adaptor inducing IFN-? (TRIF)-dependent signaling by inhibiting NF-?B activation and IRF3 activity independently of its kinase activity...
  83. Shyu H, Hsu S, Hsieh Li H, Li H. Forced expression of RNF36 induces cell apoptosis. Exp Cell Res. 2003;287:301-13 pubmed
    RNF36 (ring finger protein 36; alias Trif), a member of the RING zinc finger protein family, is expressed in germ cells at round spermatid stages during spermatogenesis...
  84. Zariri A, Beskers J, van de Waterbeemd B, Hamstra H, Bindels T, van Riet E, et al. Meningococcal Outer Membrane Vesicle Composition-Dependent Activation of the Innate Immune Response. Infect Immun. 2016;84:3024-33 pubmed publisher
    ..showed reduced induction of proinflammatory cytokines interleukin-6 (IL-6) and IL-1? but not of IP-10, a typical TRIF-dependent chemokine...
  85. Gao T, Zhang S, Wang J, Liu L, Wang Y, Cao Z, et al. TLR3 contributes to persistent autophagy and heart failure in mice after myocardial infarction. J Cell Mol Med. 2018;22:395-408 pubmed publisher
    ..Gene-knockdown experiments showed that the TRIF-dependent pathway mediated the autophagic effect of TLR3...
  86. Ono J, Shime H, Takaki H, Takashima K, Funami K, Yoshida S, et al. The TLR3/TICAM-1 signal constitutively controls spontaneous polyposis through suppression of c-Myc in Apc Min/+ mice. J Biomed Sci. 2017;24:79 pubmed publisher
    ..RNA (dsRNA), a ligand for TLR3, which activates the toll-like receptor adaptor molecule 1 (TICAM-1, also known as TRIF) pathway...
  87. Li X, Yang M, Yu Z, Tang S, Wang L, Cao X, et al. The tyrosine kinase Src promotes phosphorylation of the kinase TBK1 to facilitate type I interferon production after viral infection. Sci Signal. 2017;10: pubmed publisher
    ..TBK1 in vitro but instead bound to the proline-X-X-proline motifs within key PRR adaptor proteins, such as TRIF, MAVS, and STING, which formed complexes with TBK1 after PRR engagement...
  88. Lawlor K, Feltham R, Yabal M, Conos S, Chen K, Ziehe S, et al. XIAP Loss Triggers RIPK3- and Caspase-8-Driven IL-1? Activation and Cell Death as a Consequence of TLR-MyD88-Induced cIAP1-TRAF2 Degradation. Cell Rep. 2017;20:668-682 pubmed publisher
    ..In contrast to TLR-MyD88, TLR-TRIF-induced interferon (IFN)? inhibited cIAP1 loss and consequent cell death...
  89. Han Y, Li R, Gao J, Miao S, Wang L. Characterisation of human RING finger protein TRIM69, a novel testis E3 ubiquitin ligase and its subcellular localisation. Biochem Biophys Res Commun. 2012;429:6-11 pubmed publisher
    The E3 ubiquitin ligase activity and subcellular localisation of human TRIM69 (hTRIM69) gene were studied...
  90. Jiang Z, Liu Y, Li C, Chang L, Wang W, Wang Z, et al. IL-36? Induced by the TLR3-SLUG-VDR Axis Promotes Wound Healing via REG3A. J Invest Dermatol. 2017;137:2620-2629 pubmed publisher
    ..damaged cells via the activation of toll-like receptor 3 (TLR3) and TIR-domain-containing adapter-inducing IFN-? (TRIF) followed by the induction of a zinc finger protein SLUG to abrogate the inhibitory effect of vitamin D receptor (..
  91. Wei J, Zhang X, Zang S, Qin Q. Expression and functional characterization of TRIF in orange-spotted grouper (Epinephelus coioides). Fish Shellfish Immunol. 2017;71:295-304 pubmed publisher
    ..Toll/interleukin-1 receptor (TIR) domain containing adapter inducing interferon-? (TRIF) is an adapter in responding to activation of Toll-like receptors, which provides early clearance of viral ..
  92. Ye W, Hu M, Lei C, Zhou Q, Lin H, Sun M, et al. TRIM8 Negatively Regulates TLR3/4-Mediated Innate Immune Response by Blocking TRIF-TBK1 Interaction. J Immunol. 2017;199:1856-1864 pubmed publisher
    ..Our findings uncover an additional mechanism on the termination of TLR3/4-mediated inflammatory and innate immune responses. ..