TRIM25

Summary

Gene Symbol: TRIM25
Description: tripartite motif containing 25
Alias: EFP, RNF147, Z147, ZNF147, E3 ubiquitin/ISG15 ligase TRIM25, RING finger protein 147, RING-type E3 ubiquitin transferase, RING-type E3 ubiquitin transferase TRIM25, estrogen-responsive finger protein, tripartite motif protein TRIM25, tripartite motif-containing protein 25, ubiquitin/ISG15-conjugating enzyme TRIM25, zinc finger protein 147 (estrogen-responsive finger protein), zinc finger protein-147
Species: human
Products:     TRIM25

Top Publications

  1. Gack M, Kirchhofer A, Shin Y, Inn K, Liang C, Cui S, et al. Roles of RIG-I N-terminal tandem CARD and splice variant in TRIM25-mediated antiviral signal transduction. Proc Natl Acad Sci U S A. 2008;105:16743-8 pubmed publisher
    ..the N-terminal CARDs of RIG-I undergo the K(63)-linked ubiquitination induced by tripartite motif protein 25 (TRIM25), critical for the interaction of RIG-I with its downstream signaling partner MAVS/VISA/IPS-1/Cardif...
  2. Gack M, Albrecht R, Urano T, Inn K, Huang I, Carnero E, et al. Influenza A virus NS1 targets the ubiquitin ligase TRIM25 to evade recognition by the host viral RNA sensor RIG-I. Cell Host Microbe. 2009;5:439-49 pubmed publisher
    The ubiquitin ligase TRIM25 mediates Lysine 63-linked ubiquitination of the N-terminal CARD domains of the viral RNA sensor RIG-I to facilitate type I interferon (IFN) production and antiviral immunity...
  3. Gack M, Nistal Villán E, Inn K, Garcia Sastre A, Jung J. Phosphorylation-mediated negative regulation of RIG-I antiviral activity. J Virol. 2010;84:3220-9 pubmed publisher
    ..of viral RNA, the Lys-172 residue of RIG-I undergoes ubiquitination induced by tripartite motif protein 25 (TRIM25), an essential protein for antiviral signal transduction...
  4. Sanchez J, Okreglicka K, Chandrasekaran V, Welker J, Sundquist W, Pornillos O. The tripartite motif coiled-coil is an elongated antiparallel hairpin dimer. Proc Natl Acad Sci U S A. 2014;111:2494-9 pubmed publisher
    ..Our studies reveal how the coiled-coil organizes TRIM25 to polyubiquitylate the RIG-I/viral RNA recognition complex and how dimers of the TRIM5? protein are arranged ..
  5. Urano T, Saito T, Tsukui T, Fujita M, Hosoi T, Muramatsu M, et al. Efp targets 14-3-3 sigma for proteolysis and promotes breast tumour growth. Nature. 2002;417:871-5 pubmed
    ..b>Efp, a target gene product of ER alpha, is a member of the RING-finger B-box coiled-coil (RBCC) motif family...
  6. Kawai T, Takahashi K, Sato S, Coban C, Kumar H, Kato H, et al. IPS-1, an adaptor triggering RIG-I- and Mda5-mediated type I interferon induction. Nat Immunol. 2005;6:981-8 pubmed
    ..Knockdown' of IPS-1 by small interfering RNA blocked interferon induction by virus infection. Thus, IPS-1 is an adaptor involved in RIG-I- and Mda5-mediated antiviral immune responses. ..
  7. Nakasato N, Ikeda K, Urano T, Horie Inoue K, Takeda S, Inoue S. A ubiquitin E3 ligase Efp is up-regulated by interferons and conjugated with ISG15. Biochem Biophys Res Commun. 2006;351:540-6 pubmed
    ..Here we demonstrate that Efp mRNA as well as protein expression could be up-regulated by Type I IFN in HeLa cells and HepG2 cells...
  8. Gack M, Shin Y, Joo C, Urano T, Liang C, Sun L, et al. TRIM25 RING-finger E3 ubiquitin ligase is essential for RIG-I-mediated antiviral activity. Nature. 2007;446:916-920 pubmed
    ..that the amino-terminal caspase recruitment domains (CARDs) of RIG-I undergo robust ubiquitination induced by TRIM25 in mammalian cells...
  9. Oshiumi H, Matsumoto M, Hatakeyama S, Seya T. Riplet/RNF135, a RING finger protein, ubiquitinates RIG-I to promote interferon-beta induction during the early phase of viral infection. J Biol Chem. 2009;284:807-17 pubmed publisher
    ..Activation of RIG-I requires the ubiquitin ligase, TRIM25, which mediates lysine 63-linked polyubiquitination of the RIG-I N-terminal CARD-like region...

More Information

Publications110 found, 100 shown here

  1. Zhao K, Sikriwal D, Dong X, Guo P, Sun X, Dong J. Oestrogen causes degradation of KLF5 by inducing the E3 ubiquitin ligase EFP in ER-positive breast cancer cells. Biochem J. 2011;437:323-33 pubmed publisher
    ..The oestrogen-inducible E3 ligase EFP (oestrogen-responsive finger protein) was identified as a key player in oestrogen-mediated degradation of KLF5, as ..
  2. Oshiumi H, Matsumoto M, Seya T. Ubiquitin-mediated modulation of the cytoplasmic viral RNA sensor RIG-I. J Biochem. 2012;151:5-11 pubmed publisher
    ..RIG-I activation is regulated by ubiquitination. Three ubiquitin ligases target the RIG-I protein. TRIM25 and Riplet ubiquitin ligases are positive regulators of RIG-I and deliver the K63-linked polyubiquitin moiety to ..
  3. Liu H, Loo Y, Horner S, Zornetzer G, Katze M, Gale M. The mitochondrial targeting chaperone 14-3-3? regulates a RIG-I translocon that mediates membrane association and innate antiviral immunity. Cell Host Microbe. 2012;11:528-37 pubmed publisher
    ..and essential component of a translocation complex or "translocon" containing RIG-I, 14-3-3?, and the TRIM25 ubiquitin ligase...
  4. Gao D, Yang Y, Wang R, Zhou X, Diao F, Li M, et al. REUL is a novel E3 ubiquitin ligase and stimulator of retinoic-acid-inducible gene-I. PLoS ONE. 2009;4:e5760 pubmed publisher
    ..These findings suggest that REUL is an E3 ubiquitin ligase of RIG-I and specifically stimulates RIG-I-mediated innate antiviral activity. ..
  5. Inn K, Gack M, Tokunaga F, Shi M, Wong L, Iwai K, et al. Linear ubiquitin assembly complex negatively regulates RIG-I- and TRIM25-mediated type I interferon induction. Mol Cell. 2011;41:354-65 pubmed publisher
    Upon detection of viral RNA, retinoic acid-inducible gene I (RIG-I) undergoes TRIM25-mediated K63-linked ubiquitination, leading to type I interferon (IFN) production...
  6. Rajsbaum R, Albrecht R, Wang M, Maharaj N, Versteeg G, Nistal Villán E, et al. Species-specific inhibition of RIG-I ubiquitination and IFN induction by the influenza A virus NS1 protein. PLoS Pathog. 2012;8:e1003059 pubmed publisher
    ..The NS1 protein inhibits type-I interferon (IFN) production partly by blocking the TRIM25 ubiquitin E3 ligase-mediated Lys63-linked ubiquitination of the viral RNA sensor RIG-I, required for its optimal ..
  7. Chen L, Chien Y, Liang C, Chan C, Fan M, Huang H. Green tea extract induces genes related to browning of white adipose tissue and limits weight-gain in high energy diet-fed rat. Food Nutr Res. 2017;61:1347480 pubmed publisher
    ..morphogenetic protein-7; BW: Body weight; CIDEA: Cell death activator; CPT-1: Carnitine palmitoyltransferase-1; EFP: Epididymal fat pad; FFA: Free fatty acid; FGF-21: Fibroblast growth factor-21; GTE: Green tea extract; HDL: High-..
  8. Huang J, Wang L, Jiang M, Chen Q, Zhang X, Wang Y, et al. Low BIK outside-inside-out interactive inflammation immune-induced transcription-dependent apoptosis through FUT3-PMM2-SQSTM1-SFN-ZNF384. Immunol Res. 2016;64:461-9 pubmed publisher
    ..cell differentiation, cell cycle, regulation of cell cycle, cell proliferation, estrogen-responsive protein Efp controls cell cycle and breast tumors growth, induction or regulation of apoptosis based on integrative GO, KEGG, ..
  9. Söderholm S, Kainov D, Ohman T, Denisova O, Schepens B, Kulesskiy E, et al. Phosphoproteomics to Characterize Host Response During Influenza A Virus Infection of Human Macrophages. Mol Cell Proteomics. 2016;15:3203-3219 pubmed
    ..indicated that the phosphorylation of proteins involved in the ubiquitin/proteasome pathway (such as TRIM22 and TRIM25) and antiviral responses (such as MAVS) changed in infected macrophages...
  10. Chen Y, Xu Q, Li Y, Liu R, Huang Z, Wang B, et al. Gene expression profile after activation of RIG-I in 5'ppp-dsRNA challenged DF1. Dev Comp Immunol. 2016;65:191-200 pubmed publisher
    ..screening, a group of key responsive genes in RIG-I-mediated signaling pathways, such as ISG12-2, Mx1, IFIT5, TRIM25, USP18, STAT1, STAT2, IRF1, IRF7 and IRF8, were tested for differential expression by real-time RT-PCR...
  11. Chen Y, Lin C, Wei L, Hsu Y, Chen K, Huang C, et al. Sake Protein Supplementation Affects Exercise Performance and Biochemical Profiles in Power-Exercise-Trained Mice. Nutrients. 2016;8:106 pubmed publisher
    ..four-week PET significantly increased grip strength and exhaustive swimming time and decreased epididymal fat pad (EFP) weight and area...
  12. Torre S, Polyak M, Langlais D, Fodil N, Kennedy J, Radovanovic I, et al. USP15 regulates type I interferon response and is required for pathogenesis of neuroinflammation. Nat Immunol. 2017;18:54-63 pubmed publisher
    ..in resident brain cells, USP15 was coexpressed with, and functionally acted together with the E3 ubiquitin ligase TRIM25 to positively regulate type I interferon responses and to promote pathogenesis during neuroinflammation...
  13. Yamanaka Y, Menuki K, Zenke Y, Hirasawa H, Sakai A. Enhanced expression of Wnt9a in the flexor tenosynovium in idiopathic carpal tunnel syndrome. J Orthop Res. 2015;33:1531-6 pubmed publisher
    ..However, there was no relationship between the expression of Wnt9a and the cell proliferation index MIB-1. These results indicate that Wnt9a expression is enhanced in ICTS and that Wnt9a may be involved in VEGF expression in ICTS. ..
  14. Shu X, Zhao Y, Sun Y, Zhong L, Cheng Y, Zhang Y, et al. The epigenetic modifier PBRM1 restricts the basal activity of the innate immune system by repressing retinoic acid-inducible gene-I-like receptor signalling and is a potential prognostic biomarker for colon cancer. J Pathol. 2018;244:36-48 pubmed publisher
    ..Moreover, upregulation of RIG-I and MDA5 is required for IFN response activation induced by PBRM1 silencing. TRIM25, a protein stimulated by the RLR pathway and IFN production, physically interacted with PBRM1 and induced PBRM1 ..
  15. Sanz M, Ceriello A, Buysschaert M, Chapple I, Demmer R, Graziani F, et al. Scientific evidence on the links between periodontal diseases and diabetes: Consensus report and guidelines of the joint workshop on periodontal diseases and diabetes by the International diabetes Federation and the European Federation of Periodontol. Diabetes Res Clin Pract. 2018;137:231-241 pubmed publisher
    ..The European Federation of Periodontology (EFP) and the International Diabetes Federation (IDF) report consensus guidelines for physicians, oral healthcare ..
  16. Bao Y, Gao Y, Shi Y, Cui X. Dynamic gene expression analysis in a H1N1 influenza virus mouse pneumonia model. Virus Genes. 2017;53:357-366 pubmed publisher
    ..network analysis, and the most important genes were filtered, including Dhx58, Cxcl10, Cxcl11, Zbp1, Ifit1, Ifih1, Trim25, Mx2, Oas2, Cd274, Irgm1, and Irf7...
  17. Chen S, Wang A, Sun L, Liu F, Wang M, Jia R, et al. Immune-Related Gene Expression Patterns in GPV- or H9N2-Infected Goose Spleens. Int J Mol Sci. 2016;17: pubmed
    ..Furthermore, most of the immune-related genes, particularly TLR7, TRAF3, Mx, TRIM25, CD4, and CD8?, increased in response to GPV and H9N2 infection...
  18. Gall A, Datsenko K, Figueroa Bossi N, Bossi L, Masuda I, Hou Y, et al. Mg2+ regulates transcription of mgtA in Salmonella Typhimurium via translation of proline codons during synthesis of the MgtL peptide. Proc Natl Acad Sci U S A. 2016;113:15096-15101 pubmed publisher
    ..codons; (ii) lesions in rpmA and rpmE, which encode ribosomal proteins L27 and L31, respectively; (iii) deletion of efp, which encodes elongation factor EF-P that assists the translation of proline codons; and (iv) a heat-sensitive ..
  19. Xu C, Evensen Ø, Munang andu H. De Novo Transcriptome Analysis Shows That SAV-3 Infection Upregulates Pattern Recognition Receptors of the Endosomal Toll-Like and RIG-I-Like Receptor Signaling Pathways in Macrophage/Dendritic Like TO-Cells. Viruses. 2016;8:114 pubmed publisher
    ..The study points to possible involvement of the tripartite motif containing 25 (TRIM25) and mitochondrial antiviral signaling protein (MAVS) in modulating RIG-I signaling being the first report that ..
  20. Caniani D, Caivano M, Pascale R, Bianco G, Mancini I, Masi S, et al. CO2 and N2O from water resource recovery facilities: Evaluation of emissions from biological treatment, settling, disinfection, and receiving water body. Sci Total Environ. 2019;648:1130-1140 pubmed publisher
    ..The plant energy Footprint (eFP) was also evaluated, confirming that the aeration system is the major contributor to energy consumption, as well as ..
  21. Lee W, Lee S, Kim M, Moon J, Kim G, Jung H, et al. Vibrio vulnificus quorum-sensing molecule cyclo(Phe-Pro) inhibits RIG-I-mediated antiviral innate immunity. Nat Commun. 2018;9:1606 pubmed publisher
    ..Binding of cFP to the RIG-I 2CARD domain induces a conformational change in RIG-I, preventing the TRIM25-mediated ubiquitination to abrogate IFN production...
  22. Wang J, Ben W, Zhang Y, Yang M, Qiang Z. Effects of thermophilic composting on oxytetracycline, sulfamethazine, and their corresponding resistance genes in swine manure. Environ Sci Process Impacts. 2015;17:1654-60 pubmed publisher
    ..protection proteins remained relatively stable throughout the composting process, while those encoding efflux pump (EFP) and enzymatic inactivation (EI) proteins and sulfonamide resistance genes (SRGs) obviously increased when the ..
  23. Palaiokostas C, Robledo D, Vesely T, Prchal M, Pokorová D, Piacková V, et al. Mapping and Sequencing of a Significant Quantitative Trait Locus Affecting Resistance to Koi Herpesvirus in Common Carp. G3 (Bethesda). 2018;: pubmed publisher
    ..The TRIM25 gene was identified as a promising positional and functional candidate within the QTL region of LG 44, and a ..
  24. Cheng D, Feng Y, Liu Y, Xue J, Li Z. Dynamics of oxytetracycline, sulfamerazine, and ciprofloxacin and related antibiotic resistance genes during swine manure composting. J Environ Manage. 2018;230:102-109 pubmed publisher
    ..The tetracycline resistance genes (TRGs) encoding ribosomal protection proteins (RPP) and efflux pump (EFP) and fluoroquinolone resistance genes (FRGs) could be effectively removed after 42 days...
  25. Rajkovic A, Hummels K, Witzky A, Erickson S, Gafken P, Whitelegge J, et al. Translation Control of Swarming Proficiency in Bacillus subtilis by 5-Amino-pentanolylated Elongation Factor P. J Biol Chem. 2016;291:10976-85 pubmed publisher
    ..Prior work suggested that the EF-P-encoding gene (efp) primarily supports Bacillus subtilis swarming differentiation, whereas EF-P in Gram-negative bacteria has a more ..
  26. Rey S, Moiche V, Boltaña S, Teles M, MacKenzie S. Behavioural fever in zebrafish larvae. Dev Comp Immunol. 2017;67:287-292 pubmed publisher
    ..In parallel we measured the abundance of antiviral transcripts; viperin, gig2, irf7, trim25 and Mxb mRNAs in dsRNA challenged larvae under both thermal regimes: TR and TCh...
  27. Felde O, Kreizinger Z, Sulyok K, Marton S, Banyai K, Korbuly K, et al. Genotyping Mycoplasma hyopneumoniae isolates based on multi-locus sequence typing, multiple-locus variable-number tandem repeat analysis and analysing gene p146. Vet Microbiol. 2018;222:85-90 pubmed publisher
    ..The resolution of the three-gene (adk, rpoB, tpiA) and the seven-gene (efp, metG, pgiB, recA, adk, rpoB, tpiA) based MLST systems was identical with 27 sequence types...
  28. Park J, Yang S, Park J, Ka S, Kim J, Kong Y, et al. Positive feedback regulation of p53 transactivity by DNA damage-induced ISG15 modification. Nat Commun. 2016;7:12513 pubmed publisher
    ..Here, we show that the genes encoding ISG15, UBE1L, UBCH8 and EFP, have the p53-responsive elements and their expression is induced in a p53-dependent fashion under DNA damage ..
  29. Kathum O, Schräder T, Anhlan D, Nordhoff C, Liedmann S, Pande A, et al. Phosphorylation of influenza A virus NS1 protein at threonine 49 suppresses its interferon antagonistic activity. Cell Microbiol. 2016;18:784-91 pubmed publisher
    ..Phosphorylation impairs binding of NS1 to double-stranded RNA and TRIM25 as well as complex formation with RIG-I, thereby switching off its interferon antagonistic activity...
  30. Ikeda K, Orimo A, Higashi Y, Muramatsu M, Inoue S. Efp as a primary estrogen-responsive gene in human breast cancer. FEBS Lett. 2000;472:9-13 pubmed
    We have previously isolated the efp (estrogen-responsive finger protein) that is required for the normal estrogen-induced cell proliferation. Here, we show the genomic organization of the human efp gene which consists of nine exons...
  31. Shimada N, Suzuki T, Inoue S, Kato K, Imatani A, Sekine H, et al. Systemic distribution of estrogen-responsive finger protein (Efp) in human tissues. Mol Cell Endocrinol. 2004;218:147-53 pubmed
    Estrogen-responsive finger protein (Efp), a target gene product of estrogen receptor (ER), is considered essential for estrogen-dependent cell proliferation...
  32. Van Parys A, Boyen F, Leyman B, Verbrugghe E, Haesebrouck F, Pasmans F. Tissue-specific Salmonella Typhimurium gene expression during persistence in pigs. PLoS ONE. 2011;6:e24120 pubmed publisher
    ..We found that efp and rpoZ were specifically expressed in the ileocaecal lymph nodes during Salmonella peristence in pigs...
  33. Flint R, Rosenow J, Tate M, Slutzky M. Continuous decoding of human grasp kinematics using epidural and subdural signals. J Neural Eng. 2017;14:016005 pubmed publisher
    ..54 ± 0.05 across all subjects, 0.75 ± 0.09 for the best subject). In general, EFP decoding performed comparably to ECoG decoding...
  34. Pruitt S, Brorsen K, Gordon M. Ab initio investigation of the aqueous solvation of the nitrate ion. Phys Chem Chem Phys. 2015;17:27027-34 pubmed publisher
    ..modeled with MP2 and the water molecules are described using either the non-empirical effective fragment potential (EFP) or the empirical TIP5P potential...
  35. Tan G, Xiao Q, Song H, Ma F, Xu F, Peng D, et al. Type I IFN augments IL-27-dependent TRIM25 expression to inhibit HBV replication. Cell Mol Immunol. 2018;15:272-281 pubmed publisher
    ..b>TRIM25 is an IFN-stimulated gene (ISG) that has an important role in RIG-I ubiquitination and activation...
  36. Meyerson N, Zhou L, Guo Y, Zhao C, Tao Y, Krug R, et al. Nuclear TRIM25 Specifically Targets Influenza Virus Ribonucleoproteins to Block the Onset of RNA Chain Elongation. Cell Host Microbe. 2017;22:627-638.e7 pubmed publisher
    b>TRIM25 is an E3 ubiquitin ligase that activates RIG-I to promote the antiviral interferon response...
  37. Snodgrass W, Granberg C. Clinical indications for augmentation in children with neurogenic urinary incontinence following bladder outlet procedures: Results of a 14-year observational study. J Pediatr Urol. 2016;12:46.e1-8 pubmed publisher
    ..There were no significant differences between these patients in preoperative UD % capacity, end filling pressure (EFP), or compliance...
  38. Liu B, Zhang M, Chu H, Zhang H, Wu H, Song G, et al. The ubiquitin E3 ligase TRIM31 promotes aggregation and activation of the signaling adaptor MAVS through Lys63-linked polyubiquitination. Nat Immunol. 2017;18:214-224 pubmed publisher
    ..Our findings reveal new insights in the molecular regulation of MAVS aggregation and the cellular antiviral response through TRIM31-mediated K63-linked polyubiquitination of MAVS. ..
  39. Li M, Lau Z, Cheung P, Aguilar E, Schneider W, Bozzacco L, et al. TRIM25 Enhances the Antiviral Action of Zinc-Finger Antiviral Protein (ZAP). PLoS Pathog. 2017;13:e1006145 pubmed publisher
    ..The factor contributing most to the antiviral function of ZAP is TRIM25, an E3 ubiquitin and ISG15 ligase...
  40. Sun N, Xue Y, Dai T, Li X, Zheng N. Tripartite motif containing 25 promotes proliferation and invasion of colorectal cancer cells through TGF-β signaling. Biosci Rep. 2017;37: pubmed publisher
    Tripartite motif containing 25 (TRIM25) is a member of TRIM proteins and functions as an E3 (ubiquitin ligase)...
  41. Ansari M, Nunia S, Bansal A, Singh P, Sekhon V, Singh D, et al. Bladder contractility index in posterior urethral valve: A new marker for early prediction of progression to renal failure. J Pediatr Urol. 2018;14:162.e1-162.e5 pubmed publisher
    ..in follow-up were noted such as bladder contractility index (BCI = PdetQmax + 5 Qmax), end filling pressure (EFP), compliance (?C), bladder outlet obstruction index (BOOI = Pdet Qmax - 2 Qmax), and bladder volume efficiency ..
  42. Wang J, Zeng Y, Xu S, Yang J, Wang W, Zhong B, et al. A Naturally Occurring Deletion in the Effector Domain of H5N1 Swine Influenza Virus Nonstructural Protein 1 Regulates Viral Fitness and Host Innate Immunity. J Virol. 2018;92: pubmed publisher
    ..In addition, the EALQR-deleted NS1 protein could not bind to TRIM25, unlike full-length NS1, and was less able to block TRIM25 oligomerization and self-ubiquitination, further ..
  43. Lee N, Shin H, Kim H, Choi M, Inn K. Negative regulation of RIG-I-mediated antiviral signaling by TRK-fused gene (TFG) protein. Biochem Biophys Res Commun. 2013;437:168-72 pubmed publisher
    ..Upon detection of viral RNA, RIG-I undergoes TRIM25 (tripartite motif protein 25)-mediated K63-linked ubiquitination, leading to type I interferon (IFN) production...
  44. Qin Y, Cui H, Zhang H. Overexpression of TRIM25 in Lung Cancer Regulates Tumor Cell Progression. Technol Cancer Res Treat. 2016;15:707-15 pubmed publisher
    ..Therefore, targeting tripartite motif-containing 25 may provide a potential therapeutic intervention for lung cancer. ..
  45. Obergrussberger A, Juhász K, Thomas U, Stölzle Feix S, Becker N, Dörr L, et al. Safety pharmacology studies using EFP and impedance. J Pharmacol Toxicol Methods. 2016;81:223-32 pubmed publisher
    While extracellular field potential (EFP) recordings using multi-electrode arrays (MEAs) are a well-established technique for monitoring changes in cardiac and neuronal function, impedance is a relatively unexploited technology...
  46. Yang Y, Huang Y, Yu Y, Yang M, Zhou S, Qin Q, et al. RING domain is essential for the antiviral activity of TRIM25 from orange spotted grouper. Fish Shellfish Immunol. 2016;55:304-14 pubmed publisher
    Tripartite motif-containing 25 (TRIM25) has been demonstrated to exert crucial roles in the regulation of innate immune signaling. However, the roles of fish TRIM25 in antiviral immune response still remained uncertain...
  47. Takayama K, Suzuki T, Tanaka T, Fujimura T, Takahashi S, Urano T, et al. TRIM25 enhances cell growth and cell survival by modulating p53 signals via interaction with G3BP2 in prostate cancer. Oncogene. 2018;37:2165-2180 pubmed publisher
    ..Here, we identified tripartite motif-containing protein 25 (TRIM25)/estrogen-responsive finger protein (Efp) as a novel interacting partner of G3BP2 protein complex...
  48. Choudhury N, Nowak J, Zuo J, Rappsilber J, Spoel S, Michlewski G. Trim25 Is an RNA-Specific Activator of Lin28a/TuT4-Mediated Uridylation. Cell Rep. 2014;9:1265-72 pubmed
    ..Through RNA pull-downs coupled with quantitative mass spectrometry, we identified the E3 ligase Trim25 as an RNA-specific cofactor for Lin28a/TuT4-mediated uridylation...
  49. Zhang P, Elabd S, Hammer S, Solozobova V, Yan H, Bartel F, et al. TRIM25 has a dual function in the p53/Mdm2 circuit. Oncogene. 2015;34:5729-38 pubmed publisher
    ..In a genetic screen, we identified TRIM25 as a novel regulator of p53 and Mdm2...
  50. Liao J, Lin Y, Liang C, Hsieh W, Lee S, Tseng L. Monitoring bladder compliance using end filling detrusor pressure: Clinical results and related factors. Taiwan J Obstet Gynecol. 2015;54:709-15 pubmed publisher
    ..This study adopted an end filling detrusor pressure (EFP) greater than 20 cmH2O to define LCB. Among the study patients (n = 1490), 9...
  51. Tamura R, Ohta H, Satoh Y, Nonoyama S, Nishida Y, Nibuya M. Neuroprotective effects of adenosine deaminase in the striatum. J Cereb Blood Flow Metab. 2016;36:709-20 pubmed publisher
    ..Time courses of electrically evoked striatal field potential (eFP) and optogenetically evoked striatal field potential (optFP) were recorded during and after oxygen/glucose ..
  52. Inoue S, Orimo A, Matsuda Y, Inazawa J, Emi M, Nakamura Y, et al. Chromosome mapping of human (ZNF147) and mouse genes for estrogen-responsive finger protein (efp), a member of the RING finger family. Genomics. 1995;25:581-3 pubmed
    ..Chromosome mapping of the efp gene by fluorescence in situ hybridization reveals that human EFP (ZNF147) is located at 17q23.1 and that mouse Efp is located at 11C...
  53. Nakayama H, Sano T, Motegi A, Oyama T, Nakajima T. Increasing 14-3-3 sigma expression with declining estrogen receptor alpha and estrogen-responsive finger protein expression defines malignant progression of endometrial carcinoma. Pathol Int. 2005;55:707-15 pubmed
    ..recent study showed that 14-3-3 sigma was down-regulated through proteolysis by estrogen-responsive finger protein (Efp)...
  54. Keynan J, Meir Hasson Y, Gilam G, Cohen A, Jackont G, Kinreich S, et al. Limbic Activity Modulation Guided by Functional Magnetic Resonance Imaging-Inspired Electroencephalography Improves Implicit Emotion Regulation. Biol Psychiatry. 2016;80:490-496 pubmed publisher
    ..activity using fMRI-inspired electroencephalography (EEG), hereafter termed amygdala-electrical fingerprint (amyg-EFP)...
  55. Heo W, Uddin N, Park J, Rhee Y, Choi C, Joo T. Coherent intermolecular proton transfer in the acid-base reaction of excited state pyranine. Phys Chem Chem Phys. 2017;19:18243-18251 pubmed publisher
    ..by time-resolved fluorescence (TF) and quantum mechanical/effective fragment potential molecular dynamics (QM/EFP-MD) simulations...
  56. Qin X, Qiu F, Zou Z. TRIM25 is associated with cisplatin resistance in non-small-cell lung carcinoma A549 cell line via downregulation of 14-3-3?. Biochem Biophys Res Commun. 2017;493:568-572 pubmed publisher
    ..We previously reported that Tripartite motif protein 25 (TRIM25) was highly expressed in cisplatin-resistant human lung adenocarcinoma A549 cells (A549/CDDP) in comparison with ..
  57. Zhenilo S, Deyev I, Litvinova E, Zhigalova N, Kaplun D, Sokolov A, et al. DeSUMOylation switches Kaiso from activator to repressor upon hyperosmotic stress. Cell Death Differ. 2018;: pubmed publisher
    ..b>TRIM25 was significantly repressed in two K42R HEK293 clones...
  58. Inoue S, Orimo A, Hosoi T, Kondo S, Toyoshima H, Kondo T, et al. Genomic binding-site cloning reveals an estrogen-responsive gene that encodes a RING finger protein. Proc Natl Acad Sci U S A. 1993;90:11117-21 pubmed
    ..motif present in a family of apparent DNA-binding proteins and is designated estrogen-responsive finger protein (efp)...
  59. Suzuki T, Urano T, Tsukui T, Horie Inoue K, Moriya T, Ishida T, et al. Estrogen-responsive finger protein as a new potential biomarker for breast cancer. Clin Cancer Res. 2005;11:6148-54 pubmed
    Estrogen-responsive finger protein (Efp) is a member of RING finger-B box-Coiled Coil family and is also a downstream target of estrogen receptor alpha...
  60. Dong X, Fu X, Fan S, Guo P, Su D, Dong J. Oestrogen causes ATBF1 protein degradation through the oestrogen-responsive E3 ubiquitin ligase EFP. Biochem J. 2012;444:581-90 pubmed publisher
    ..In the present study we show that EFP (oestrogen-responsive finger protein) is an E3 ubiquitin ligase mediating oestrogen-induced ATBF1 protein ..
  61. Nakajima A, Maruyama S, Bohgaki M, Miyajima N, Tsukiyama T, Sakuragi N, et al. Ligand-dependent transcription of estrogen receptor alpha is mediated by the ubiquitin ligase EFP. Biochem Biophys Res Commun. 2007;357:245-51 pubmed
    ..We show that the estrogen-responsive finger protein (EFP) interacts with and ubiquitylates ERalpha...
  62. Xia Z, Sun L, Chen X, Pineda G, Jiang X, Adhikari A, et al. Direct activation of protein kinases by unanchored polyubiquitin chains. Nature. 2009;461:114-9 pubmed publisher
    ..These results indicate that unanchored polyubiquitin chains directly activate TAK1 and IKK, suggesting a new mechanism of protein kinase regulation. ..
  63. Park J, Yang S, Yu K, Ka S, Lee S, Seol J, et al. Modification of PCNA by ISG15 plays a crucial role in termination of error-prone translesion DNA synthesis. Mol Cell. 2014;54:626-38 pubmed publisher
    ..Upon UV irradiation, EFP, an ISG15 E3 ligase, bound to mono-ubiquitinated PCNA and promoted its ISGylation...
  64. Heikel G, Choudhury N, Michlewski G. The role of Trim25 in development, disease and RNA metabolism. Biochem Soc Trans. 2016;44:1045-50 pubmed publisher
    b>Trim25 is a member of the tripartite motif family of E3 ubiquitin ligases. It plays major roles in innate immunity and defence against viral infection, control of cell proliferation and migration of cancer cells...
  65. Gong B, Wang Z, Zhang M, Hu Z, Ren Z, Tang Z, et al. Disturbed P53-MDM2 Feedback Loop Contributes to Thoracic Aortic Dissection Formation and May be a Result of TRIM25 Overexpression. Ann Vasc Surg. 2017;40:243-251 pubmed publisher
    ..murine double minute 2) feedback loop in the formation of TAD, and one of a potential feedback loop regulator, TRIM25 (tripartite motif protein-25)...
  66. Bogey R, Barnes L. Estimates of individual muscle power production in normal adult walking. J Neuroeng Rehabil. 2017;14:92 pubmed publisher
    ..An EMG-to-force processing (EFP) model was developed which scaled muscle-tendon unit (MTU) force output to gait EMG...
  67. Mattei A, Fish J, Hilgert M, Lövby T, Svensson M, Vaughan J, et al. The 2015 ENFSI Fingerprint Working Group testing programme. Forensic Sci Int. 2017;280:55-63 pubmed publisher
    As early as 2004, the Fingerprint Working Group (EFP-WG) of the European Network of Forensic Science Institutes (ENFSI) has organised proficiency tests (PT's), as well as collaborative exercises (CE's), as a way of raising standards ..
  68. Zhang M, Zhang W, Tan J, Zhao M, Lian L, Cai J. Poly r(C) binding protein (PCBP) 1 expression is regulated by the E3 ligase UBE4A in thyroid carcinoma. Biosci Rep. 2017;37: pubmed publisher
    ..Low UBE4A expression level was associated with a better prognosis in thyroid cancer patients. Our data reveal a post-translational regulatory mechanism of regulating PCBP1 expression in thyroid cancer cells. ..
  69. Manzoli V, Villa C, Bayer A, Morales L, Molano R, Torrente Y, et al. Immunoisolation of Murine Islet Allografts in Vascularized Sites Through Conformal Coating with Polyethylene Glycol. Am J Transplant. 2017;: pubmed publisher
    ..We showed that islet transplantation in confined well-vascularized sites like the epididymal fat pad (EFP) improved graft outcomes, but only conformal coated (CC) islets can be implanted in these sites in curative doses...
  70. Horie K, Urano T, Ikeda K, Inoue S. Estrogen-responsive RING finger protein controls breast cancer growth. J Steroid Biochem Mol Biol. 2003;85:101-4 pubmed
    ..Estrogen-responsive finger protein (Efp) is one of the estrogen receptor (ER)-target genes we have cloned using genomic binding site cloning...
  71. Zou W, Wang J, Zhang D. Negative regulation of ISG15 E3 ligase EFP through its autoISGylation. Biochem Biophys Res Commun. 2007;354:321-7 pubmed
    ..Our previous study identified the interferon inducible protein EFP as an ISG15 isopeptide ligase (E3) for 14-3-3sigma...
  72. Britto A, Amoedo N, Pezzuto P, Afonso A, Martinez A, Silveira J, et al. Expression levels of the innate response gene RIG-I and its regulators RNF125 and TRIM25 in HIV-1-infected adult and pediatric individuals. AIDS. 2013;27:1879-85 pubmed publisher
    ..As the ubiquitin ligases RNF125 and TRIM25 are involved in regulating RIG-I function, our aim was to assess whether the levels of these three genes vary ..
  73. Lee N, Kim H, Choi M, Yi C, Inn K. Regulation of MDA5-MAVS Antiviral Signaling Axis by TRIM25 through TRAF6-Mediated NF-κB Activation. Mol Cells. 2015;38:759-64 pubmed publisher
    Tripartite motif protein 25 (TRIM25), mediates K63-linked polyubiquitination of Retinoic acid inducible gene I (RIG-I) that is crucial for downstream antiviral interferon signaling...
  74. Touma Z, Thavaneswaran A, Chandran V, Pellett F, Cook R, Gladman D. Clinical and Demographic Characteristics of Erosion-free and Erosion-present Status in Psoriatic Arthritis in a Cohort Study. J Rheumatol. 2016;43:1057-62 pubmed publisher
    ..We aimed to determine the prevalence, characteristics, and predictors of erosion-free patients (EFP) as compared with erosion-present patients (EPP) among patients with PsA followed prospectively.
  75. Koliopoulos M, Esposito D, Christodoulou E, Taylor I, Rittinger K. Functional role of TRIM E3 ligase oligomerization and regulation of catalytic activity. EMBO J. 2016;35:1204-18 pubmed publisher
    ..Here, we provide a detailed characterization of the TRIM ligases TRIM25 and TRIM32 and show how their oligomeric state is linked to catalytic activity...
  76. Walsh L, Alvarez M, Sabio E, Reyngold M, Makarov V, Mukherjee S, et al. An Integrated Systems Biology Approach Identifies TRIM25 as a Key Determinant of Breast Cancer Metastasis. Cell Rep. 2017;20:1623-1640 pubmed publisher
    ..Our analyses confirmed established pro-metastatic transcription factors, and they uncovered TRIM25 as a key regulator of metastasis-related transcriptional programs...
  77. Zang H, Ren S, Cao H, Tian X. The ubiquitin ligase TRIM25 inhibits hepatocellular carcinoma progression by targeting metastasis associated 1 protein. IUBMB Life. 2017;69:795-801 pubmed publisher
    ..RNAi-mediated silencing of each prospective ubiquitin ligase in THLE-2 cells indicated that knockdown of TRIM25 resulted in stabilization of MTA1 protein, indicating TRIM25 as a putative E3 ligase for MTA1...
  78. Klee S, Mostafa I, Chen S, Dufresne C, Lehman B, Sinn J, et al. An Erwinia amylovora yjeK mutant exhibits reduced virulence, increased chemical sensitivity, and numerous environmentally dependent proteomic alterations. Mol Plant Pathol. 2017;: pubmed publisher
    ..to be essential for full virulence of Escherichia coli, Salmonella species, and Agrobacterium tumefaciens, with efp, yjeA, and yjeK mutants having highly similar phenotypes. Here, we identified an E...
  79. Wang P, Arjona A, Zhang Y, Sultana H, Dai J, Yang L, et al. Caspase-12 controls West Nile virus infection via the viral RNA receptor RIG-I. Nat Immunol. 2010;11:912-9 pubmed publisher
    ..showed that caspase-12 positively modulated the production of type I interferon by regulating E3 ubiquitin ligase TRIM25-mediated ubiquitination of RIG-I, a critical signaling event for the type I interferon response to WNV and other ..
  80. Feng M, Ding Z, Xu L, Kong L, Wang W, Jiao S, et al. Structural and biochemical studies of RIG-I antiviral signaling. Protein Cell. 2013;4:142-54 pubmed publisher
    ..of dsRNA, while S8E and T170E phosphorylation-mimicking mutants of RIG-I were defective in binding E3 ligase TRIM25, unanchored K63-linked polyubiquitin, and MAVS regardless of dsRNA...
  81. Oshiumi H, Miyashita M, Matsumoto M, Seya T. A distinct role of Riplet-mediated K63-Linked polyubiquitination of the RIG-I repressor domain in human antiviral innate immune responses. PLoS Pathog. 2013;9:e1003533 pubmed publisher
    ..RIG-I activation is regulated by the K63-linked polyubiquitin chain mediated by Riplet and TRIM25 ubiquitin ligases. TRIM25 is required for RIG-I oligomerization and interaction with the IPS-1 adaptor molecule...
  82. Wang Y, Ha S, Zhang T, Kho D, Raz A, Xie Y. Polyubiquitylation of AMF requires cooperation between the gp78 and TRIM25 ubiquitin ligases. Oncotarget. 2014;5:2044-51 pubmed publisher
    ..We show that polyubiquitylation of AMF requires cooperative interaction between gp78 and the ubiquitin ligase TRIM25 (tripartite motif-containing protein 25)...
  83. Zhu Z, Wang Y, Zhang C, Yu S, Zhu Q, Hou K, et al. TRIM25 blockade by RNA interference inhibited migration and invasion of gastric cancer cells through TGF-β signaling. Sci Rep. 2016;6:19070 pubmed publisher
    Tripartite Motif Containing 25 (TRIM25), a member of TRIM proteins, has been found abnormally expressed in cancers of female reproductive system...
  84. Sanchez J, Chiang J, Sparrer K, Alam S, Chi M, Roganowicz M, et al. Mechanism of TRIM25 Catalytic Activation in the Antiviral RIG-I Pathway. Cell Rep. 2016;16:1315-1325 pubmed publisher
    ..signalosome is regulated by K63-linked polyubiquitin chains, which are synthesized by the E3 ubiquitin ligase, TRIM25. We have previously shown that the TRIM25 coiled-coil domain is a stable, antiparallel dimer that positions two ..
  85. Mao H, Du Y, Zhang Z, Cao B, Zhao J, Zhou H, et al. Nitroxoline shows antimyeloma activity by targeting the TRIM25/p53 axle. Anticancer Drugs. 2017;28:376-383 pubmed publisher
    ..In the mechanistic study, NXQ was found to downregulate TRIM25, a highly expressed ubiquitin ligase in MM. Notably, NXQ upregulated tumor suppressor p53, but not PTEN...
  86. Nebgen B, Magurudeniya H, Kwock K, Ringstrand B, Ahmed T, Seifert S, et al. Design principles from multiscale simulations to predict nanostructure in self-assembling ionic liquids. Faraday Discuss. 2017;: pubmed publisher
    ..with three anions; chloride, nitrate, and thiocyanate as aqueous mixtures, using the effective fragment potential (EFP) method, a computationally inexpensive way of modeling intermolecular interactions...
  87. Sanchez Aparicio M, Feinman L, Garcia Sastre A, Shaw M. Paramyxovirus V Proteins Interact with the RIG-I/TRIM25 Regulatory Complex and Inhibit RIG-I Signaling. J Virol. 2018;92: pubmed publisher
    ..We report interactions between the Nipah virus V protein and both RIG-I regulatory protein TRIM25 and RIG-I...
  88. Ikeda K, Inoue S, Orimo A, Sano M, Watanabe T, Tsutsumi K, et al. Multiple regulatory elements and binding proteins of the 5'-flanking region of the human estrogen-responsive finger protein (efp) gene. Biochem Biophys Res Commun. 1997;236:765-71 pubmed
    The efp, a member of the RING finger family, was previously identified as an estrogen responsive gene. Here, we characterized basal promoter of the human efp gene...
  89. Ludwig S, Wolff T. Influenza A virus TRIMs the type I interferon response. Cell Host Microbe. 2009;5:420-1 pubmed publisher
    ..For influenza viruses, a unique strategy has now been unraveled, as the viral nonstructural protein 1 was shown to inhibit activation of the pathogen recognition receptor RIG-I by binding the ubiquitin ligase TRIM25.
  90. Dai H, Zhao S, Xu L, Chen A, Dai S. Expression of Efp, VEGF and bFGF in normal, hyperplastic and malignant endometrial tissue. Oncol Rep. 2010;23:795-9 pubmed
    ..We investigated the expression of estrogen-responsive ring finger protein (Efp), VEGF and bFGF in endometrial cancer and correlated the results with clinicopathological features...
  91. Ronchi V, Haas A. Measuring rates of ubiquitin chain formation as a functional readout of ligase activity. Methods Mol Biol. 2012;832:197-218 pubmed publisher
    ..These kinetic methods provide mechanistic insights that are otherwise inaccessible by other experimental approaches and yield a precision in characterizing protein interactions that exceeds that of other techniques. ..
  92. Marblestone J, Larocque J, Mattern M, Leach C. Analysis of ubiquitin E3 ligase activity using selective polyubiquitin binding proteins. Biochim Biophys Acta. 2012;1823:2094-7 pubmed publisher
    ..This article is part of a Special Issue entitled: Ubiquitin Drug Discovery and Diagnostics. ..