Genomes and Genes
Gene Symbol: TIE1
Description: tyrosine kinase with immunoglobulin like and EGF like domains 1
Alias: JTK14, TIE, tyrosine-protein kinase receptor Tie-1, tyrosine kinase with immunoglobulin and epidermal growth factor homology domains 1
Publications700 found, 100 shown here
- [Expression of angiopoietin-1 and its tyrosine kinase receptor Tie-2 in the airway of asthmatic rats]Jun Ying Qiao
Department of Pediatrics, Third Affiliated Hospital of Zhengzhou University, Zhengzhou 450052, China
Zhongguo Dang Dai Er Ke Za Zhi 10:642-6. 2008To study the effect of dexamethasone on airway morphology and on the expression of angiopoietin-1 (Ang-1) and its tyrosine kinase receptor Tie-2 in the airway of asthmatic rats.
- A noncoding antisense RNA in tie-1 locus regulates tie-1 function in vivoKeguo Li
Department of Pediatrics, Medical College of Wisconsin, Developmental Vascular Biology Program, Children s Research Institute, Milwaukee, USA
Blood 115:133-9. 2010..natural AS transcript for tyrosine kinase containing immunoglobulin and epidermal growth factor homology domain-1 (tie-1), tie-1AS lncRNA in zebrafish, mouse, and humans...
- Expression of VEGF receptors VEFGR-1 and VEGFR-2, angiopoietin receptors Tie-1 and Tie-2 in chorionic villi tree during early pregnancyRamazan Demir
Department of Histology and Embryology, Faculty of Medicine, Akdeniz University, Antalya, Turkey
Folia Histochem Cytobiol 47:435-45. 2009..In the mesenchymal villi and immature intermediate villi VEGFR-1 and -2, and angiopoietin receptors Tie-1 and -2 immunoreactivity was dominantly observed in the heamangiogenic cells and cells cords, whereas the matured ..
- Expression of angiopoietin-1, 2 and 4 and Tie-1 and 2 in gastrointestinal stromal tumor, leiomyoma and schwannomaToshiyuki Nakayama
Department of Tumor and Diagnostic Pathology, Nagasaki University Graduate School of Biomedical Sciences, 1 12 4 Sakamoto, Nagasaki, Japan
World J Gastroenterol 13:4473-9. 2007To investigate the role of angiopoietin (Ang) -1, -2 and -4 and its receptors, Tie-1 and -2, in the growth and differentiation of gastrointestinal stromal tumors (GISTs).
- tie-1 protein tyrosine kinase: a novel independent prognostic marker for gastric cancerW C Lin
Institute of Biomedical Sciences, Academia Sinica, Taipei, Taiwan, Republic of China
Clin Cancer Res 5:1745-51. 1999..We have identified 17 PTKs from a gastric adenocarcinoma. Two receptor PTKs, tie-1 and axl, were selected for in situ immunohistochemistry studies because of their higher expression level and ..
- Tie-1 receptor tyrosine kinase endodomain interaction with SHP2: potential signalling mechanisms and roles in angiogenesisM B Marron
University of Leicester Cardiovascular Research Institute, UK
Adv Exp Med Biol 476:35-46. 2000..The ligands responsible for activating Tie-1, its signalling pathways and specific cellular functions are however not known...
- The distribution of angiopoietin-1, angiopoietin-2 and their receptors tie-1 and tie-2 in the very early human placentaY Seval
Department of Histology and Embryology, Faculty of Medicine, Akdeniz University, 07070 Antalya, Turkey
Placenta 29:809-15. 2008..The current study assessed expression of angiopoietins (Ang-1 and Ang-2) and their receptors (Tie-1 and Tie-2) during development of the early human placenta...
- Suppression of Tie-1 in endothelial cells in vitro induces a change in the genome-wide expression profile reflecting an inflammatory functionBarden Chan
Division of Interdisciplinary Medicine and Biotechnology, Department of Medicine, Beth Israel Deaconess Medical Center, Harvard Medical School, Boston, MA 02215, USA
FEBS Lett 583:1023-8. 2009b>Tie-1 is an endothelial specific receptor tyrosine kinase that is upregulated in diseases such as atherosclerosis and rheumatoid arthritis...
- Regulated proteolytic processing of Tie1 modulates ligand responsiveness of the receptor-tyrosine kinase Tie2Marie B Marron
Department of Cardiovascular Sciences, University of Leicester, Robert Kilpatrick Clinical Sciences Bld, P O Box 65, Leicester, LE2 7LX United Kingdom
J Biol Chem 282:30509-17. 2007..The receptor-tyrosine kinase Tie1 is known to undergo ectodomain cleavage generating a membrane-tethered endodomain...
- A novel endothelial cell surface receptor tyrosine kinase with extracellular epidermal growth factor homology domainsJ Partanen
Department of Virology, University of Helsinki, Finland
Mol Cell Biol 12:1698-707. 1992..Here we describe the cloning and characterization of tie, a novel type of human endothelial cell surface receptor tyrosine kinase...
- The endothelial receptor tyrosine kinase Tie1 activates phosphatidylinositol 3-kinase and Akt to inhibit apoptosisChristopher D Kontos
Department of Medicine, Division of Cardiology, Duke University Medical Center, Durham, NC 27710, USA
Mol Cell Biol 22:1704-13. 2002b>Tie1 is an orphan receptor tyrosine kinase that is expressed almost exclusively in endothelial cells and that is required for normal embryonic vascular development...
- Vascular endothelial growth factor modulates the Tie-2:Tie-1 receptor complexAchilleas C Tsiamis
Department of Surgery, University of Leicester, RKCSB, Leicester, LE2 7LX, United Kingdom
Microvasc Res 63:149-58. 2002The receptor tyrosine kinase Tie-1 is expressed predominantly in endothelial cells where it physically associates with the related receptor Tie-2...
- Evidence for heterotypic interaction between the receptor tyrosine kinases TIE-1 and TIE-2M B Marron
Department of Surgery, University of Leicester, RKCSB, P O Box 65, Leicester LE2 7LX, United Kingdom
J Biol Chem 275:39741-6. 2000The orphan receptor tyrosine kinase Tie-1 is expressed in endothelial cells and is essential for vascular development. Nothing is known about the signaling pathways utilized by this receptor...
- Institutional change. Experiences in two departmentsH J Humphrey
Department of Medicine, University of Chicago, IL, USA
J Gen Intern Med 12:S79-82. 1997..The most basic element is to tie reward and recognition to efforts in primary care.
- Control of DAF-7 TGF-(alpha) expression and neuronal process development by a receptor tyrosine kinase KIN-8 in Caenorhabditis elegansM Koga
Department of Biology, Graduate School of Sciences, Kyushu University, Fukuoka, Japan
Development 126:5387-98. 1999..KIN-8 is required for the process development of ASI, and also involved in promotion of daf-7 expression through a physiological or developmental function...
- Hybrid tyrosine kinase/cytokine receptors transmit mitogenic signals in response to ligandR E Pacifici
Department of Molecular Biology, Amgen Inc, Amgen Center, Thousand Oaks, California 91320
J Biol Chem 269:1571-4. 1994....
- Toxicological characterisation of sludge from sewage treatment plants using toxicity identification evaluation protocols based on in vitro toxicity testsM M Babín
Laboratory of Ecotoxicology, Department of Environmentally Sustainable Development, INIA, Crta La Coruña km 7, 28040 Madrid, Spain
Toxicol In Vitro 15:519-24. 2001..Toxicity identification evaluation (TIE) protocols, developed by the United States Environmental Protection Agency (US EPA); to identify toxic pollutants ..
- Preeclampsia and small-for-gestational age are associated with decreased concentrations of a factor involved in angiogenesis: soluble Tie-2Francesca Gotsch
Perinatology Research Branch, NICHD NIH DHHS, Bethesda, Maryland, USA
J Matern Fetal Neonatal Med 21:389-402. 2008..angiopoietin-1 (Ang-1) and angiopoietin-2 (Ang-2), both ligands for the tyrosine kinase endothelial cell receptor Tie-2. These angiogenic factors have been proposed to promote angiogenesis in a coordinated and complementary fashion...
- [Therapy of lung diseases with antiproteases]C Vogelmeier
Pneumologische Abteilung Klimikum Grosshadern,
Pneumologie 48:57-62. 1994..found that aerosolized rSLPI a) is not altered in its form or function in the first 13 h following aerosol; b) has a half-tie of 12 h in the lung; c) reaches the interstitium of the lung in intact form.(ABSTRACT TRUNCATED AT 250 WORDS)
- In vivo modulators of antibody kineticsA Jekunen
Department of Oncology, Helsinki University Central Hospital, Helsinki
Acta Oncol 35:267-71. 1996..after injecting I-125 labeled IgG1 monoclonal antibody (3c4c7g6) raised against a tyrosine kinase receptor protein Tie. Expression of Tie is known to be abundant in vascular endothelia and possibly related to malignant angiogenesis...
- Insulin action is mimicked by polyclonal antireceptor antibodies that activate the insulin receptor tyrosine kinaseM Caron
Laboratoire de Biochimie, INSERM U181, , Paris, France
Horm Metab Res 21:295-300. 1989..Taken together, these results are consistent with a role for the kinase activity of the insulin receptor in mediating the action of insulin...
- Angiopoietin-1 and angiopoietin-2 share the same binding domains in the Tie-2 receptor involving the first Ig-like loop and the epidermal growth factor-like repeatsUlrike Fiedler
Department of Vascular Biology and Angiogenesis Research, Tumor Biology Center, 79106 Freiburg, Germany
J Biol Chem 278:1721-7. 2003..with different effector functions of the vascular assembly and maturation-mediating receptor tyrosine kinase Tie-2...
- Insulin-receptor tyrosine kinase activity is decreased in erythrocytes from non-obese patients with NIDDMR F Santos
Laboratory of Human Nutrition and Metabolic Diseases, School of Medicine, , Brazil
Horm Metab Res 26:283-7. 1994..e. decrease in activity) observed in patients with NIDDM is probably related to a reduction in coupling efficiency between insulin binding and the activation of the receptor tyrosine kinase activity...
- Effects of tibolone and its metabolites on Angiopoietin-1, Tie-2 and tumor necrosis factor-alpha mRNA in Ishikawa cells. Implication for tibolone's effects on the endometriumSebastian Mirkin
CONRAD Clinical Research Center, Jones Institute for Reproductive Medicine, Eastern Virginia Medical School, USA
Maturitas 57:338-46. 2007..the effect of 17beta-estradiol, medroxyprogesterone acetate, tibolone and tibolone metabolites on Angiopoietin-1, Tie-2, and tumor necrosis factor-alpha in Ishikawa cells, in vitro...
- Divergent regulation of angiopoietin-1 and -2, Tie-2, and thrombospondin-1 expression by estrogen in the baboon endometriumThomas W Bonagura
Department of Obstetrics, Gynecology and Reproductive Sciences, Center for Studies in Reproduction, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
Mol Reprod Dev 77:430-8. 2010..effect of estrogen on the expression of these angioregulatory factors in the endometrium, Ang-1, Ang-2, TSP-1, and Tie-2 receptor mRNA levels were assessed by real-time reverse transcriptase polymerase chain reaction in glandular ..
- Non-invasive measurement of mechanical properties of arteries in health and diseaseA P Hoeks
Department of Biophysics, Cardiovascular Research Institute, Maastricht, The Netherlands
Proc Inst Mech Eng H 213:195-202. 1999..e., the tie-dependent change in diameter, the relative pulsatile increase in diameter, and pulse wave velocity, for elastic and ..
- Critical role of angiopoietins/Tie-2 in hyperglycemic exacerbation of myocardial infarction and impaired angiogenesisQin Hui Tuo
Division of Neonatology, Department of Pediatrics, Vanderbilt University Medical Center, Nashville, Tennessee, USA
Am J Physiol Heart Circ Physiol 294:H2547-57. 2008Angiopoietin-1 (Ang-1) and angiopoietin-2 (Ang-2) are the two ligands of the Tie-2 receptor, a receptor tyrosine kinase that is expressed on the endothelium...
- Inflammatory cytokines and vascular endothelial growth factor stimulate the release of soluble tie receptor from human endothelial cells via metalloprotease activationR Yabkowitz
Departments of Mammalian Cell Molecular Biology, Experimental Hematology, Protein Structure, and Protein Chemistry, Amgen Inc, Thousand Oaks, CA, USA
Blood 93:1969-79. 1999..Previously, we demonstrated that release of soluble tie-1 receptor from endothelial cells by phorbol myristate acetate (PMA) is mediated through protein kinase C and a Ca2+..
- Separation and purification of recombinant proteins from Escherichia coli with aqueous two-phase systemsJ A Asenjo
Biochemical Engineering Laboratory, University of Reading, UK
J Chromatogr A 668:129-37. 1994..The PEG top phase was recycled to the first extraction stage. The stability ratio (tie-line length) had an effect on the average partition coefficient (Kapp) of E...
- Human recombinant alpha 2-HS glycoprotein is produced in insect cells as a full length inhibitor of the insulin receptor tyrosine kinaseL Kalabay
3rd Department of Medicine, Semmelweis University Medical School, Budapest, Hungary
Horm Metab Res 30:1-6. 1998..1)...
- Space flight modulates signal transduction pathway of growth factor receptors in rat osteoblastsY Kumei
Tokyo Medical and Dental Univ
Biol Sci Space 13:142-3. 1999..The purpose of this study is to investigate the mRNA levels for PDGF-beta receptor, EGF receptor, Shc, and c-fos in rat osteoblasts during space flight...
- Selective inhibition of the epidermal growth factor receptor tyrosine kinase by BIBX1382BS and the improvement of growth delay, but not local control, after fractionated irradiation in human FaDu squamous cell carcinoma in the nude mouseM Baumann
Clinic of Radiation Oncology, Medical Faculty Carl Gustav Carus, University of Technology, Dresden, Germany
Int J Radiat Biol 79:547-59. 2003..FaDu human squamous cell carcinoma is epidermal growth factor receptor positive and significant repopulation during fractionated irradiation was demonstrated in previous experiments...
- Sensitive high-resolution analysis of biological molecules by capillary zone electrophoresis coupled with reflecting time-of-flight mass spectrometryM E McComb
Department of Chemistry, University of Manitoba, Winnipeg, Canada
J Chromatogr A 800:1-11. 1998..On-line CZE-ESI-TOF-MS measurements of the total ion electropherogram (TIE) and of selected ion electropherograms (SIE) on peptide mixtures demonstrated fmol-level sensitivity, with S/N ..
- Novel 4-anilinoquinazolines with C-7 basic side chains: design and structure activity relationship of a series of potent, orally active, VEGF receptor tyrosine kinase inhibitorsLaurent F Hennequin
AstraZeneca, Centre de Recherches, Z I la Pompelle, B P 1050, Chemin de Vrilly, 51689 Reims, Cedex 2, France
J Med Chem 45:1300-12. 2002..04 microM) vs the kinase activity of erbB2, MEK, CDK-2, Tie-2, IGFR-1R, PDK, PDGFRbeta, and AKT (IC(50) range: 1.1 to >100 microM)...
- The Tie-2 ligand angiopoietin-2 is stored in and rapidly released upon stimulation from endothelial cell Weibel-Palade bodiesUlrike Fiedler
Department of Vascular Biology and Angiogenesis Research Tumor Biology Center, Breisacher Str 117, 79106 Freiburg, Germany
Blood 103:4150-6. 2004..Ang-1 and Ang-2 have been identified as ligands with opposing functions of the receptor tyrosine kinase Tie-2 regulating endothelial cell survival and vascular maturation...
- Angiopoietin-2 sensitizes endothelial cells to TNF-alpha and has a crucial role in the induction of inflammationUlrike Fiedler
Department of Vascular Biology and Angiogenesis Research, Tumor Biology Center, Freiburg 79106, Germany
Nat Med 12:235-9. 2006The angiopoietins Ang-1 and Ang-2 have been identified as ligands of the receptor tyrosine kinase Tie-2 (refs. 1,2). Paracrine Ang-1-mediated activation of Tie-2 acts as a regulator of vessel maturation and vascular quiescence...
- LigaSure vs clamp-and-tie technique to achieve hemostasis in total thyroidectomy for benign multinodular goiter: a prospective randomized studyOlivier Saint Marc
Service de Chirurgie Digestive Endocrinienne et Thoracique, centre hospitalier régional d Orléans, Orleans, France
Arch Surg 142:150-6; discussion 157. 2007..have not been tested in prospective randomized studies comparing its use with that of the time-saving clamp-and-tie technique to ligate and divide thyroid vessels...
- Glucose transporter (GLUT 4) content and insulin receptor kinase activity in muscles of the LA/N-cp ratM Kern
Department of Medicine, Stanford University School of Medicine, California
Horm Metab Res 26:129-32. 1994..These data indicate that there are at least two defects in the insulin action cascade in muscle from LA/N-cp rats that contribute to the insulin resistance in these animals...
- Characterization of TEK receptor tyrosine kinase and its ligands, Angiopoietins, in human hematopoietic progenitor cellsA Sato
Department of Cell Differentiation, Institute of Molecular Embryology and Genetics, Kumamoto University School of Medicine, Honjo, Japan
Int Immunol 10:1217-27. 1998TEK, or TIE-2, is a receptor tyrosine kinase (RTK) that is known as a functioning molecule of vascular endothelial cells...
- Expression of angiopoietin-1, angiopoietin-2, and the Tie-2 receptor tyrosine kinase during mouse kidney maturationH T Yuan
Nephrourology Unit, Institute of Child Health, University College London, Medical School, United Kingdom
J Am Soc Nephrol 10:1722-36. 1999The Tie-2 receptor tyrosine kinase transduces embryonic endothelial differentiation, with Angiopoietin-1 (Ang-1) acting as a stimulatory ligand and Ang-2 postulated to be a naturally occurring inhibitor...
- Expression and function of the angiopoietin receptor Tie-2 in human eosinophilsClemens Feistritzer
Division of General Internal Medicine, Department of Internal Medicine, Medical University of Innsbruck, Anichstrasse 35, A 6020 Innsbruck, Austria
J Allergy Clin Immunol 114:1077-84. 2004..Increased vascularity of bronchial mucosa is closely related to the expression of angiogenic factors, which contribute to the pathogenesis of diseases such as asthma bronchiale...
- Administration of a gonadotropin-releasing hormone agonist affects corpus luteum vascular stability and development and induces luteal apoptosis in a rat model of ovarian hyperstimulation syndromeLeopoldina Scotti
Instituto de Biologia y Medicina Experimental CONICET, Buenos Aires, Argentina
Mol Cell Endocrinol 335:116-25. 2011..to analyze the in vivo effect of a GnRH-I agonist on corpus luteum development and regression, ANGPT-1, ANGPT-2 and Tie-2 protein expression and luteal blood vessel stabilization, the expression of the steroidogenic acute regulatory ..
- Angiopoietin/Tek interactions regulate mmp-9 expression and retinal neovascularizationArup Das
Department of Surgery, University of New Mexico School of Medicine, Albuquerque, New Mexico
Lab Invest 83:1637-45. 2003..The effects of inhibiting angiopoietin binding to the Tie-2 receptor was studied in newborn mice with experimentally induced retinal neovascularization...
- [Assessment of the selected, late phase of angiogenesis factors' concentration in colorectal cancer patients]Maria Wieloch
Szpital MSWiA w Łodzi, Oddział Chirurgii Ogólnej
Pol Merkur Lekarski 27:466-9. 2009..THE AIM OF THE STUDY was to compare the angiopoietin-1(Ang-1), angiopoietin-2 (Ang-2) and Tie-2 receptor (rec...
- How do angiopoietins Tie in with vascular endothelial growth factors?Pipsa Saharinen
Molecular and Cancer Biology Program, Biomedicum Helsinki, University of Helsinki, Finland
Curr Opin Hematol 17:198-205. 2010..specific receptor tyrosine kinase systems, the vascular endothelial growth factor (VEGF) receptors (VEGFRs) and the Tie receptors, activated by the VEGF and angiopoietin ligands, respectively...
- Expression of Tie1, Tie2, and angiopoietins 1, 2, and 4 in Kaposi's sarcoma and cutaneous angiosarcomaL F Brown
Department of Pathology, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, MA 02215, USA
Am J Pathol 156:2179-83. 2000The angiopoietins are recently described growth factors for vascular endothelium. The Tie1 and Tie2 receptors are expressed by endothelium...
- Differential expression of angiopoietins 1 and 2 and their receptor Tie-2 in human endometriumJens Hirchenhain
Department of Obstetrics and Gynecology, Heinrich Heine University Medical Center, Moorenstrasse 5, D 40225 Dusseldorf, Germany
Mol Hum Reprod 9:663-9. 2003..Ang-1) and angiopoietin-2 (Ang-2) are ligands for the endothelial cell-specific receptor tyrosine kinase Tie-2...
- Angiopoietin-1, angiopoietin-2 and tie-2 in the coronary circulation of patients with and without coronary collateral vesselsWataru Mitsuma
Division of Cardiology, Niigata University Graduate School of Medical and Dental Sciences, Niigata, Japan
Circ J 71:343-7. 2007The role of the angiopoietin (Ang)/Tie-2 system in coronary collateral growth is not well understood, so the purpose of this study was to investigate and elucidate the relationship of this system to coronary collateral formation in ..
- Circulating angiopoietin 2 correlates with mortality in a surgical population with acute lung injury/adult respiratory distress syndromeDiana C Gallagher
Division of Pulmonary, Critical Care, and Sleep Medicine, Beth Israel Deaconess Medical Center, Boston, MA 02215, USA
Shock 29:656-61. 2008..b>Tie 2 is a tyrosine kinase receptor expressed on endothelial cells...
- Expressional regulation of the angiopoietin-1 and -2 and the endothelial-specific receptor tyrosine kinase Tie2 in adrenal atrophy: a study of adrenocorticotropin-induced repairOlivier Feraud
Equipe Mixte Institut National de la Santé et de la Recherche Médicale, EMI 02 19, Laboratoire de Développement et Vieillissement de l Endothélium, 38054 Grenoble Cedex 9, France
Endocrinology 144:4607-15. 2003Angiopoietin-1 (Ang-1), a newly discovered ligand of the endothelial-specific tyrosine kinase receptor Tie-2, has been found to promote cell survival, vascular maturation, and stabilization, and to function in concert with vascular ..
- Ephrin-B2 reverse signaling is required for axon pathfinding and cardiac valve formation but not early vascular developmentChad A Cowan
Center for Developmental Biology and Kent Waldrep Center for Basic Research on Nerve Growth and Regeneration, University of Texas Southwestern Medical Center, Dallas, TX 75390 9133, USA
Dev Biol 271:263-71. 2004..These include the vascular endothelial growth factor receptors (VEGFR-1 and VEGFR-2) that bind VEGF, the Tie-1 and Tie-2 receptors that bind the angiopoietins, and the EphB4 receptor that binds the membrane-anchored ligand ..
- The full-length, cytoplasmic C-terminus of the beta 2-adrenergic receptor expressed in E. coli acts as a substrate for phosphorylation by protein kinase A, insulin receptor tyrosine kinase, GRK2, but not protein kinase C and suppresses desensitization wheS Doronin
Department of Molecular Pharmacology, University Medical Center, SUNY Stony Brook, Stony Brook, New York 11794, USA
Protein Expr Purif 20:451-61. 2000..coli acts as a functional domain, displaying fidelity with regard to protein kinase action in vivo and acting as a dominant-negative with respect to agonist-induced desensitization...
- Production and localization of Muc4/sialomucin complex and its receptor tyrosine kinase ErbB2 in the rat lacrimal glandM E Arango
Department of Cell Biology and Anatomy, University of Miami School of Medicine, Florida 33101, USA
Invest Ophthalmol Vis Sci 42:2749-56. 2001..To show the presence and forms of sialomucin complex (rat Muc4) and receptor tyrosine kinase ErbBs in the rat lacrimal gland and analyze for complexes of ErbB2 and its ligand Muc4...
- Sole ulcers in Finnish dairy cattleMinna Kujala
Faculty of Veterinary Medicine, Department of Production Animal Medicine, University of Helsinki, Saari Unit, Pohjoinen Pikatie 800, FIN 04920 Saarentaus, Finland
Prev Vet Med 89:227-36. 2009..logistic models with hoof trimmer and farms (within hoof trimmer) as random effects were fit to data sets of tie stall (TS) and loose housing (LH) herds separately...
- Transgenic mice with overexpression of human scavenger receptor A on endothelial cellsL Wan
Research Center of Molecular Biology, Nanhua University, Hengyang 421001, China
Chin Med J (Engl) 114:1078-83. 2001..To establish a new transgenic mouse model for determining the function and role of human scavenger receptor A (SR-A) in atherosclerosis in vivo...
- Effects of angiopoietins-1 and -2 on the receptor tyrosine kinase Tie2 are differentially regulated at the endothelial cell surfaceTania M Hansen
University of Leicester, Department of Cardiovascular Sciences, RKCSB, PO Box 65, Leicester LE2 7LX, UK
Cell Signal 22:527-32. 2010..Previous work has shown that Ang1 binding and activation of Tie2 are inhibited by Tie1, a related receptor that complexes with Tie2 in cells...
- Hypoxia up-regulates angiopoietin-2, a Tie-2 ligand, in mouse mesangial cellsH T Yuan
Nephro Urology Unit, Institute of Child Health, University College London, London, England, United Kingdom
Kidney Int 58:1912-9. 2000..Our previous studies demonstrated angiopoietin-2 (Ang-2) promoter activity in vivo in maturing kidney vascular smooth muscle and mesangial cells, with Tie-2 expressed by adjacent endothelia, including glomerular capillaries.
- Maternal serum angiopoietin-1 and -2 and tie-2 in early pregnancy ending in preeclampsia or intrauterine growth retardationElina Leinonen
Department of Obstetrics and Gynecology, Helsinki University Central Hospital, Biomedicum, Helsinki 00029 HUS, Finland
J Clin Endocrinol Metab 95:126-33. 2010..antagonizes, whereas angiopoietin-1 (Ang-1) activates the endothelial cell-specific tyrosine kinase receptor-2 (Tie-2). In preeclampsia, circulating concentrations of Ang-1 are increased and those of Ang-2 and Tie-2 are decreased.
- Cell autonomous functions of the receptor tyrosine kinase TIE in a late phase of angiogenic capillary growth and endothelial cell survival during murine developmentJ Partanen
Program in Molecular Biology and Cancer, Mount Sinai Hospital, Toronto, Ontario, Canada
Development 122:3013-21. 1996b>TIE is a receptor tyrosine kinase expressed in both mature endothelial cells and their precursors, as well as in some hematopoietic cells...
- Expression of endothelial cell-associated molecules in AML cellsM Watarai
Department of Internal Medicine, Division of Hematology, Aichi Medical University School of Medicine, Nagakute, Aichi, Japan
Leukemia 16:112-9. 2002..and endothelial cells by analyzing the expression profile of angiogenic factors, angiopoietin-1 (Ang-1), Ang-2, Tie-2 (a receptor for angiopoietins) and vascular endothelial growth factor (VEGF)...
- Requirement for the TIE family of receptor tyrosine kinases in adult but not fetal hematopoiesisMira C Puri
Samuel Lunenfeld Research Institute, Program in Molecular Biology and Cancer, Mount Sinai Hospital, 600 University Avenue, Toronto, Ontario, Canada M5G 1X5
Proc Natl Acad Sci U S A 100:12753-8. 2003..b>TIE1 (TIE) and TIE2 (TEK) are related receptor tyrosine kinases with an embryonic expression pattern in endothelial ..
- Expression of Angiopoietin-1 and the receptor Tie-2 mRNA in rat brains following intracerebral hemorrhageHuajun Zhou
Institute of Integrative Medicine, Xiangya Hospital, Central South University Changsha, Hunan, People s Republic of China
Acta Neurobiol Exp (Wars) 68:147-54. 2008..family of endothelial growth factors that function as ligands for an endothelialspecific receptor tyrosine kinase (Tie-2)...
- Angiopoietin-1 protects mesenchymal stem cells against serum deprivation and hypoxia-induced apoptosis through the PI3K/Akt pathwayXian Bao Liu
Department of Cardiology, Second Affiliated Hospital, School of Medicine, Zhejiang University, Hangzhou 310009, China
Acta Pharmacol Sin 29:815-22. 2008The angiopoietin-1 (Ang1)/Tie-2 signaling system not only plays a pivotal role in vessel growth, remodeling, and maturation, but also reduces apoptosis of endothelial cells, neurons, and cardiomyocytes...
- Identification of a family of alternatively spliced mRNA species of angiopoietin-1Y Q Huang
New York University School of Medicine and Kaplan Cancer Center, New York, NY 10016, USA
Blood 95:1993-9. 2000..Ang-1 has been identified as the ligand for the tyrosine kinase receptor Tie-2, which is expressed specifically on endothelial cells and early hematopoietic cells...
- Effects of pharmacist participation in intensive care units on clinical and economic outcomes of critically ill patients with thromboembolic or infarction-related eventsRobert MacLaren
Department of Clinical Pharmacy, School of Pharmacy, University of Colorado Denver, Aurora, Colorado 80045, USA
Pharmacotherapy 29:761-8. 2009To assess the effects of clinical pharmacist participation in the care of critically ill Medicare patients with thromboembolic or infarction-related events (TIE) on clinical and economic outcomes.
- PI3-kinase is involved in mitogenic signaling by the oncogenic receptor tyrosine kinase Xiphophorus melanoma receptor kinase in fish melanomaC Wellbrock
Biocenter Theodor Boveri Institut, University of Wurzburg, Wurzburg, Germany
Exp Cell Res 251:340-9. 1999..Together these data demonstrate that PI3-kinase is a substrate of the oncogenic Xmrk receptor and plays a significant role in mitogenic signaling of melanoma cells and the formation of malignant melanoma in Xiphophorus...
- AEE788: a dual family epidermal growth factor receptor/ErbB2 and vascular endothelial growth factor receptor tyrosine kinase inhibitor with antitumor and antiangiogenic activityPeter Traxler
Oncology Research, Novartis Institutes for BioMedical Research, Klybeckstrasse, CH 4002 Basel, Switzerland
Cancer Res 64:4931-41. 2004..Consequently, AEE788 is currently in Phase I clinical trials in oncology...
- The angiopoietin/Tie-2 system regulates pericyte survival and recruitment in diabetic retinopathyJun Cai
Department of Ophthalmology and Visual Sciences, The University of Texas Medical Branch, 301 University Boulevard, Galveston, TX 77550, USA
Invest Ophthalmol Vis Sci 49:2163-71. 2008..The hypothesis for the study was that, in addition to modulating endothelial cell behavior, the angiopoietin/Tie-2 system also regulates the pericyte apoptosis and/or the vessel maturation associated with diabetic retinopathy.
- SpTie1/2 is expressed in coelomocytes, axial organ and embryos of the sea urchin Strongylocentrotus purpuratus, and is an orthologue of vertebrate Tie1 and Tie2Margaret E Stevens
Department of Biology, Ripon College, Ripon Wisconsin, United States
Dev Comp Immunol 34:884-95. 2010A full length cDNA sequence expressed in coelomocytes shows significant sequence match to vertebrate Tie1 and Tie2/TEK...
- Altered gene expression of brain-derived neurotrophic factor and receptor tyrosine kinase B in postmortem brain of suicide subjectsYogesh Dwivedi
Psychiatric Institute, Department of Psychiatry, University of Illinois at Chicago, 60612, USA
Arch Gen Psychiatry 60:804-15. 2003....
- The Bone Tie. A new device for interfragmentary fixationD Sammut
Department of Plastic Surgery, Frenchay Hospital, Bristol, UK
J Hand Surg Br 24:64-9. 1999..The Bone Tie uses an old architectural principle to hold bone fragments together with minimal surgical dissection for access...
- What makes a man similar to a tie? Stimulus compatibility with comparison and integrationE J Wisniewski
University of North Carolina at Greensboro
Cogn Psychol 39:208-38. 1999..We believe that single-process models should be extended to take this interplay into account...
- Anti-fibrotic activity and enhanced interleukin-6 production by hepatic stellate cells in response to imatinib mesylateYoungchul Kim
Division of Liver Diseases, Department of Medicine, The Mount Sinai School of Medicine, New York, NY 10029 6574, USA
Liver Int 32:1008-17. 2012..The hepatic stellate cell (HSC) is a key target of anti-fibrotic therapies. Imatinib mesylate is a small molecule receptor tyrosine kinase inhibitor indicated for treatment of chronic myelogenous leukaemia and GI stromal tumours...
- Targeting myeloid-derived suppressor cells with colony stimulating factor-1 receptor blockade can reverse immune resistance to immunotherapy in indoleamine 2,3-dioxygenase-expressing tumorsRikke B Holmgaard
Swim Across America Ludwig Collaborative Laboratory, Memorial Sloan Kettering Cancer Center, New York, NY, United States
EBioMedicine 6:50-8. 2016..These findings provide evidence for a critical and functional role for MDSCs on the in vivo outcome of IDO-expressing tumors. ..
- ARIA, a protein that stimulates acetylcholine receptor synthesis, is a member of the neu ligand familyD L Falls
Neurobiology Department, Harvard Medical School, Boston, Massachusetts 02115
Cell 72:801-15. 1993..Our data suggest that members of the ARIA protein family promote the formation and maintenance of chemical synapses and, furthermore, that receptor tyrosine kinases play important roles in this process...
- Interaction of the molecular weight 85K regulatory subunit of the phosphatidylinositol 3-kinase with the insulin receptor and the insulin-like growth factor-1 (IGF- I) receptor: comparative study using the yeast two-hybrid systemS Tartare-Deckert
INSERM, Nice Cedex 2, France
Endocrinology 137:1019-24. 1996..the IGF-IR remains to be determined, it is tempting to propose that they contribute, at least in part, to the specificity of the biological responses induced by insulin vs. IGF-1...
- The deubiquitination enzyme fat facets negatively regulates RTK/Ras/MAPK signalling during Drosophila eye developmentA Isaksson
European Molecular Biology Laboratory, EMBL, Heidelberg, Germany
Mech Dev 68:59-67. 1997..These studies demonstrate the relevance of ubiquitin-dependent protein degradation in the regulation of RTK/Ras signal transduction in an intact organism...
- Epidermal growth factor receptor tyrosine kinase inhibitors as anticancer agentsF Ciardiello
Cattedra di Oncologia Medica, Dipartimento di Endocrinologia e Oncologia Molecolare e Clinica, Universita degli Studi di Napoli Federico II, Italy
Drugs 60:25-32; discussion 41-2. 2000..Preclinical data for ZD1839 strongly support the possibility of potentiating the antitumour activity of conventional chemotherapy with agents that selectively block the EGFR...
- Sediment toxicity identification evaluation (TIE) studies at marine sites suspected of ordnance contaminationR S Carr
U S Geological Survey, BRD, CERC, Marine Ecotoxicology Research Station, Texas A and M University Corpus Christi, Center for Coastal Studies, 6300 Ocean Drive, NRC, Suite 3200, Corpus Christi, Texas 78412, USA
Arch Environ Contam Toxicol 41:298-307. 2001A sediment quality assessment survey and subsequent toxicity identification evaluation (TIE) study was conducted at several sites in Puget Sound, Washington. The sites were previously suspected of contamination with ordnance compounds...
- Robinow syndromeM A Patton
Department of Medical Genetics, St George s Hospital Medical School, Cranmer Terrace, London SW17 0RE, UK
J Med Genet 39:305-10. 2002..The same gene, ROR2, has been shown to cause autosomal dominant brachydactyly B, but it is not known at present whether the autosomal dominant form of Robinow syndrome is also caused by mutations in ROR2...
- Tramtrack69 is required for the early repression of tailless expressionYueh Jung Chen
Institute of Genetics, National Yang Ming University, Shih Pai, Taipei 112, Taiwan, ROC
Mech Dev 116:75-83. 2002..Further, in wild-type embryos, the tll-MRR mutated in TC5 drives uniform lacZ expression before late stage 4. We conclude that TTK69 is required for early (before the end of stage 4) repression of tll transcription...
- SH3 domain-mediated binding of the Drk protein to Dos is an important step in signaling of Drosophila receptor tyrosine kinasesStephan M Feller
Cancer Research UK, Weatherall Institute of Molecular Medicine, John Radcliffe Hospital, Headington, Oxford OX3 9DS, UK
Mech Dev 116:129-39. 2002..Mutational analysis in vitro and in vivo provided evidence that both Drk binding sites fulfil an important function in the context of Sev and Drosophila epidermal growth factor receptor mediated signaling processes...
- Redox regulation of protein tyrosine phosphatases during receptor tyrosine kinase signal transductionPaola Chiarugi
Dipartimento di Scienze Biochimiche, Universita di Firenze, Viale Morgagni 50, 50134 Florence, Italy
Trends Biochem Sci 28:509-14. 2003..We propose that signal transduction by oxygen species through reversible phosphotyrosine phosphatase inhibition, represents a widespread and conserved component of the biochemical machinery that is triggered by RTKs...
- G protein-coupled receptors and their signaling pathways: classical therapeutical targets susceptible to novel therapeutic conceptsClaus Liebmann
Institute of Biochemistry and Biophysics, Biological and Pharmaceutical Faculty, Friedrich Schiller University, Philosophenweg 12, D 07743 Jena, Germany
Curr Pharm Des 10:1937-58. 2004....
- Localization of NGF and TrkA at mitotic apparatus in human glioma cell line U251Zhijian Zhang
School of Medicine, Jiangsu University, Jiangsu Zhenjiang 212001, China
Biochem Biophys Res Commun 337:68-74. 2005..The phosphorylated TrkA with the tyrosine kinase activity may phosphorylate the tubulin and promote the mitotic spindle assembly. By these mechanisms, NGF can modulate the mitosis of human glioma cells...
- Old habits tie hard: an in vitro comparison of first-throw tension holding in Polyglycolic acid (Dexon S) and Polyglactin 910 (Coated Vicryl)Thomas L Kersey
Royal Eye Infirmary, Mutley Plain, Plymouth, UK
Clin Exp Ophthalmol 34:152-5. 2006..To compare the first-throw tension holding property of two braided absorbable sutures commonly used in oculoplastic surgery...
- Small molecule inhibitors of protein kinases in cancer- how to overcome resistanceR Griffith
School of Environmental and Life Sciences, Faculty of Science and IT, University of Newcastle, Callaghan NSW 2308, Australia
Mini Rev Med Chem 6:1101-10. 2006..These are reviewed and illustrated using the receptor tyrosine kinase, KIT, as an example. Emerging solutions are presented, such as targeting active kinase conformations...
- Quantitative protein analysis from formalin-fixed tissues: implications for translational clinical research and nanoscale molecular diagnosisK F Becker
Technische Universitat, Institut fur Pathologie, Munchen, Germany
J Pathol 211:370-8. 2007..This technique may also be used to identify, characterize, and validate known and new protein markers in a variety of human diseases...
- KRAS mutation is an important predictor of resistance to therapy with epidermal growth factor receptor tyrosine kinase inhibitors in non-small-cell lung cancerErminia Massarelli
Department of Thoracic Head and Neck Medical Oncology, The University of Texas M D Anderson Cancer Center, Houston, Texas 77030 4009, USA
Clin Cancer Res 13:2890-6. 2007..In contrast, KRAS mutation has been shown to predict poor response to such therapy. We tested the utility of combinations of these three markers in predicting response and survival in patients with NSCLC treated with EGFR-TKIs...
- Chlamydial symbionts in the enigmatic Xenoturbella (Deuterostomia)Olle Israelsson
Museum of Evolution, Uppsala University, Norbyvägen 16, S 752 36 Uppsala, Sweden
J Invertebr Pathol 96:213-20. 2007..They have flattened disk-shaped elementary bodies, either oval or bow tie-shaped in cross-section, and reticulate bodies that are spherical, polygonal or irregularly shaped...
- Requirement of TrkB for synapse elimination in developing cerebellar Purkinje cellsLaurens W J Bosman
Institut für Neurowissenschaften, Technische Universitat Munchen, Biedersteiner Strasse 29, 80802, Munchen, Germany
Brain Cell Biol 35:87-101. 2006..Thus, our results demonstrate an involvement of TrkB receptors in synapse elimination and reveal a new role for receptor tyrosine kinases in the brain...
- Stable isotopic labeling by amino acids in cultured primary neurons: application to brain-derived neurotrophic factor-dependent phosphotyrosine-associated signalingDaniel S Spellman
Department of Pharmacology, Skirball Institute of Biomolecular Medicine, New York University School of Medicine, New York, New York 10016, USA
Mol Cell Proteomics 7:1067-76. 2008..These results demonstrate that the combination of primary neuronal cell culture and SILAC can be a powerful tool for the study of the proteomes of neuronal molecular and cellular dynamics...
- Application of ATP bioluminescence for evaluation of surface cleanliness of milking equipmentM J Vilar
Instituto de Investigacion y Analisis Alimentarios, Universidad de Santiago de Compostela, Campus Universitario s n 27002, Lugo, Spain
Int J Food Microbiol 125:357-61. 2008..containers, milk receivers, and pipeline joints) in dairy farms in Galicia (northwest Spain) with parlour, pipeline tie-stall or bucket tie-stall milking systems. The cleanest surfaces were teat cup rubbers...
- Computer simulations reveal a novel nucleotide-type binding orientation for ellipticine-based anticancer c-kit kinase inhibitorsDamien Thompson
Tyndall National Institute, Lee Maltings, Cork, Ireland
Biochemistry 47:10333-44. 2008....
- Orphan receptor tyrosine kinase ROR2 as a potential therapeutic target for osteosarcomaKazuhito Morioka
Laboratory of Molecular Medicine, Human Genome Center, Institute of Medical Science, University of Tokyo, Tokyo, Japan
Cancer Sci 100:1227-33. 2009..Taken together, our findings revealed that the WNT5B/ROR2 signaling pathway is a promising therapeutic target for osteosarcoma...
- Signaling pathways involved in DNA synthesis and migration in response to lysophosphatidic acid and low-density lipoprotein in coronary artery smooth muscle cellsMayumi Komachi
Laboratory of Signal Transduction, Institute for Molecular and Cellular Regulation, Gunma University, 3 39 15 Showo machi, Maebashi 371 8512, Japan
Vascul Pharmacol 50:178-84. 2009..Ca2+/calcineurin pathways and transactivation of EGF receptors mediate LPA1-receptor-induced DNA synthesis and migration, respectively...
- Non-receptor tyrosine kinase Src is required for ischemia-stimulated neuronal cell proliferation via Raf/ERK/CREB activation in the dentate gyrusHe ping Tian
Department of Neurosurgery, First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China
BMC Neurosci 10:139. 2009..This study was designed to investigate the potential regulatory capacity of non-receptor tyrosine kinase Src on ischemia-stimulated cell proliferation in the adult DG and its underlying mechanism...
- TrkB agonist antibody dose-dependently raises blood pressure in mice with diet-induced obesityLingfei Xu
Novartis Institutes for BioMedical Research and Novartis Pharmaceutical Company, East Hanover, New Jersey, USA
Am J Hypertens 23:732-6. 2010..However, because BDNF can raise blood pressure (BP) acutely, it is possible that chronic TrkB activation will produce adverse cardiovascular effects...
- Anaplastic Lymphoma Kinase: role in specific tumours, and development of small molecule inhibitors for cancer therapyE Ardini
Department of Cell Biology, Oncology, Nerviano Medical Sciences S r l, Viale Pasteur 10, 20014 Nerviano, Milan, Italy
Cancer Lett 299:81-94. 2010..In this review, we describe the various oncogenic forms of ALK, relevant clinical settings, and give a detailed overview of current drug discovery efforts in the field...
- Cetuximab monotherapy in patients with advanced non-small cell lung cancer after prior epidermal growth factor receptor tyrosine kinase inhibitor therapyJoel W Neal
Massachusetts General Hospital Cancer Center, Massachusetts General Hospital, Boston, Massachusetts 02114, USA
J Thorac Oncol 5:1855-8. 2010..Cetuximab is a monoclonal antibody against the EGFR receptor with antitumor activity in NSCLC. This study evaluated the efficacy of cetuximab monotherapy after prior treatment with an oral EGFR tyrosine kinase inhibitor (TKI)...
- The Ron receptor promotes prostate tumor growth in the TRAMP mouse modelM N Thobe
Department of Cancer and Cell Biology, University of Cincinnati College of Medicine, OH, USA
Oncogene 30:4990-8. 2011..In total, our data show for the first time that Ron promotes prostate tumor growth, prostate tumor angiogenesis and prostate cancer cell survival in vivo...
- Phosphotyrosine signaling pathways controlling tracheal tube geometryKAI G ZINN; Fiscal Year: 2013..We can also analyze tyrosine phosphorylation of the proteins and determine if they physically interact with each other in the embryo. ..
- Khalid Matrougui; Fiscal Year: 2014..The goal of our studies is to determine how increased Epidermal Growth Factor Receptor tyrosine kinase activity compromises coronary arteriolar function in type 2 diabetes. ..
- The central role of c-Met in H. pylori pathogenesis.Sarah E Keates; Fiscal Year: 2010..Results from these studies should lead to a better understanding of the disease mechanisms involved in the development of H. pylori-mediated gastric carcinogenesis. ..
- GI PEPTIDE SIGNALING THROUGH TYROSINE PHOSPHORYLATIONJUAN ENRIQUE ROZENGURT; Fiscal Year: 2010....
- TOPOISOMERASE I INHIBITORS IN LEUKEMIA AND SOLID TUMORSScott H Kaufmann; Fiscal Year: 2010..Collectively, these studies are designed to provide new insight into the mechanism of action of topo I poisons, and identify strategies for enhancing their efficacy. ..
- Philip A Cole; Fiscal Year: 2016..abstract_text> ..
- DEVELOPMENT OF CANCER IMAGING AGENTSHenry VanBrocklin; Fiscal Year: 2000..Additionally, it will provide inroads into new areas of research in drug discovery and therapeutic intervention. ..
- GERTRUD M SCHUPBACH; Fiscal Year: 2016..Our work identifies further genes that act in the same pathway as the receptor and these genes will provide new targets for specific cancer drugs as well as allowing us to address side effects of available cancer drugs. ..
- Fu Shin X Yu; Fiscal Year: 2016....
- Gadiparthi N Rao; Fiscal Year: 2016....
- Jia Luo; Fiscal Year: 2016..Understanding the interactions among alcohol, ErbB2 and MUC1 will also provide an important insight into the pathogenesis of some human diseases related to alcohol abuse as well as alcohol's teratogenic effect during development. ..
- Barry M Gumbiner; Fiscal Year: 2014..Findings from these studies should reveal how contact inhibition regulates normal tissue development and how the loss of contact inhibition leads to the formation and progression of tumors. ..
- Pasi A Janne; Fiscal Year: 2016..Findings from these studies have therapeutic implications for patients with cancers harboring genomic alterations in RET and catalyze the development of clinical trials for such patients. ..
- Regulation of EGFR Signaling by the Endocytic PathwayBrian P Ceresa; Fiscal Year: 2013..The immediate goal of this research is to better understand the molecular mechanisms that regulate the biological and pathological functions of the EGFR and use that information for treatment of diseases associated with the EGFR. ..
- Jessica E Treisman; Fiscal Year: 2016..Taken together, the proposal will reveal new molecular mechanisms in a conserved signaling pathway that is critical for retinal development. ..
- Receptor Tyrosine Kinase Signaling NetworksJoannes B Hoek; Fiscal Year: 2010....
- Advanced Anatomic and Functional Response Assessment in Lung CancerLawrence H Schwartz; Fiscal Year: 2011..3. To determine if the use of a continuous scale best overall response better predicts than the categorical response assessment currently used. ..
- Ron Bose; Fiscal Year: 2016..This information will identify new patients who are likely to benefit from Her2 targeted drugs and will provide the key scientific findings to support a future breast cancer clinical trial. ..
- Matthew L Meyerson; Fiscal Year: 2016....
- Epidermal growth factor receptor signaling in gliomaJoon Uhm; Fiscal Year: 2006..abstract_text> ..
- Redox regulation of phagocyte NOX2 in inflammation and agingRobert A Clark; Fiscal Year: 2013....
- Inflammatory Proteases, Ubiquitin Proteasome System, and Myocyte DeathAbdelkarim Sabri; Fiscal Year: 2012....
- Apoptotic T Cell Clearance From Murine LungsJeffrey L Curtis; Fiscal Year: 2010..This project studies a molecule called MerTK that appears to control clearance. Understanding MerTK could lead to new treatments to prevent complications of many types of lung damage. ..
- Receptor Tyrosine Kinase Sorting and Transactivation in EndosomesMARK LINDSAY GRIMES; Fiscal Year: 2010..These studies are also relevant to the use of stem cells for nerve regeneration. ..
- Susan E Waltz; Fiscal Year: 2016..The focus of this proposal is to define the role of a novel protein, termed Ron, and Ron- dependent signaling pathways as potential new therapeutic targets to combat this disease. ..
- Quantitative Analysis of RET Receptor Activation and SignalingAdrian Whitty; Fiscal Year: 2013..abstract_text> ..
- Role of Paxillin in Lung CancerRavi Salgia; Fiscal Year: 2012..Our goal is to study the role of paxillin in lung cancer and ultimately arrive at novel therapy against this difficult disease. ..
- Ack1: Activation and Consequences in Prostate CancerHENRY SHELTON EARP; Fiscal Year: 2012..This proposal has the potential to yield significant new information about how Ack1 promotes prostate cancer progression and may lead to novel ways of treating prostate cancer patients by targeting Ack1 tyrosine kinase with new drugs. ..
- Mechanisms of BDNF and Glucocorticoid ActionMichael J Garabedian; Fiscal Year: 2013..abstract_text> ..
- Goutam Ghosh Choudhury; Fiscal Year: 2016....
- Lecia V Sequist; Fiscal Year: 2016..In this grant proposal, we aim to identify how these cancers become resistant so that we can design effective therapies to overcome this resistance and provide benefit to our patients. ..
- Wenqin Luo; Fiscal Year: 2016..Results from this research will greatly improve our understanding of how mammalian mechanoreceptors develop and provide insight into axonal regeneration after injuries. ..
- HERVE F AGAISSE; Fiscal Year: 2014..These exploratory studies may provide mechanistic insight into molecular and cellular processes relevant to the treatment and prevention of diseases caused by pathogens that exploit the actin cytoskeleton for their dissemination. ..
- Norbert Perrimon; Fiscal Year: 2014..The success of this application will provide a benchmark for reconstructing signaling networks on a global scale. ..
- Regulation of Endothelial Cell Function by SproutyRobert E Friesel; Fiscal Year: 2010..Our goal is to study these pathways at the cellular, molecular and genetic level to increase our knowledge to enable the development new treatments for cardiovascular disease. ..
- Robert A Anders; Fiscal Year: 2014..Third, we specifically tie the lymphotoxin receptor to the production of IL-6 and the intrahepatic cellular response...
- The role of serine phosphorylation of IRS-2 in hepatic insulin resistanceXiao Sun; Fiscal Year: 2009..The results from this investigation should provide a clearer, integrative understanding of the molecular determinants of insulin sensitivity in the liver as well as the whole organism. ..
- SIGNALING BY MUSK, A COMPONENT OF THE AGRIN RECEPTORSTEVEN BURDEN; Fiscal Year: 2012..The experiments described here are designed to determine how Lrp4 and Dok-7, two newly discovered components of this signaling pathway mediate Agrin responsiveness, lead to MuSK phosphorylation and stimulate synaptic differentiation. ..
- Targeting RON Receptor Signaling in Pancreatic CancerAndrew M Lowy; Fiscal Year: 2010..In this proposal, we will examine the effects of blocking RON receptor function by two different methods in order to determine if this can reverse pancreatic cancer growth alone and in combination with chemotherapy. ..
- Novel Estrogen Receptor Phosphorylation Sites in Sensitivity/Resistance to SERMsChristopher Williams; Fiscal Year: 2011..Furthermore these studies may lead to improved therapeutic regimens for breast cancer patients, by targeting kinases associated with resistance. ..
- Role of Cytokine Signaling in Intestinal RestitutionNarendra Kumar; Fiscal Year: 2013....
- Gangjian Qin; Fiscal Year: 2015....
- Modulation of ErbB Receptor Tyrosine Kinase SignalingKermit L Carraway; Fiscal Year: 2011..Specific Aim 2 examines the molecular mechanisms by which Muc4 alters receptor trafficking and localization. ..
- Design of novel c-Met inhibitors inspired by olive phenolicsKhalid A El Sayed; Fiscal Year: 2013..Anticipated new information will facilitate important therapeutic advances for alleviation and prevention of c-Met dependent malignancies. ..
- Forest M White; Fiscal Year: 2015..The proposed studies use innovative experimental approaches to reveal new mechanistic insights necessary for building more powerful and accurate models. ..
- LINDA JOY PIKE; Fiscal Year: 2015..These studies will provide a more accurate and comprehensive foundation upon which to base research strategies and clinical choices for the development and utilization of ErbB-targeted therapeutics. ..
- Elisa Boscolo; Fiscal Year: 2016....
- Samir M Parikh; Fiscal Year: 2016DESCRIPTION (provided by applicant): The Tie-2 receptor is highly and specifically expressed in endothelial cells. Its global constitutive activation in mature blood vessels is thought to mediate vascular quiescence...
- Adam Zlotnick; Fiscal Year: 2015..Based on theory, we suggest that the most effective approach will be to enhance assembly to tie up many core proteins in unproductive complexes...
- Angiopoietins in AngiogenesisQin Yu; Fiscal Year: 2006..Angiopoietins are three closely related proteins that serve as ligands of Tie-2 receptor tyrosine kinase...
- Paul E Micevych; Fiscal Year: 2016..cultures to work out cell signaling pathways, and whole animal experiments to verify the in vitro results and tie them to regulation of the LH surge...
- Subhash C Pandey; Fiscal Year: 2016....
- EXPRESSION PROFILES FOR RET-POSITIVE DRG NEURONSSanjay Jain; Fiscal Year: 2013..Interactions with members of other GUDMAP projects and the community will provide synergies that will accelerate discovery and mechanism based projects related to pelvic visceral sensory system. ..
- Anti-Fibrotic Therapy for Scleroderma/SScLatha Paka; Fiscal Year: 2010..The objective of this application is to evaluate a lead small- molecule drug candidate in two preclinical models of scleroderma/SSc to advance to SBIR Phase-II project with the ultimate objective of bringing our drug to clinical trials. ..
- Hypertension and Collagen: Effect of Ac-SDKPNour Eddine Rhaleb; Fiscal Year: 2010..Consequently, it will identify another component (Ac-SDKP) as part of the multiple mediators participating in the cardioprotective effects of ACEi in hypertension. ..
- Ephrin-A3 in Neuron-Glia CommunicationElena B Pasquale; Fiscal Year: 2011..Strategies to manipulate ephrin function in glial cells could help treatment of neurological disorders involving aberrant neuron-glia interactions in the hippocampus and other regions of the nervous system. ..
- Optimization of EphA4 antagonists for CNS disordersELENA B contact PASQUALE; Fiscal Year: 2010..The optimized antagonists will be useful to further study the physiological and pathological functions of EphA4 and may serve as starting points for drug development to treat disorders of the nervous system. ..
- Jordan A Kreidberg; Fiscal Year: 2014..Failure to ubquitinate c-Met is due to sequestration of the E3 ubiquitin ligase c-Cbl by 31 integrin in the Golgi apparatus. This grant will investigate the roles of c-Cbl, c-Met and protein glycosylation in the pathogenesis of PKD. ..
- Michael R Freeman; Fiscal Year: 2014..DRF3 loss and the MAT may also be functionally important in other solid tumor systems. Consequently, these studies may provide information of more general significance to human cancer. ..
- Genetic Basis for Impaired Angiogenic Signaling in BPDSTEVEN HERBERT ABMAN; Fiscal Year: 2012..critical interactions between VEGF-NO signaling and other angiogenic molecules, including the angiopoietin-Tie 2 system, endothelin-1, and prostacyclin, and circulating endothelial progenitor cells (EPCs) in lung growth and ..
- Role of DDR2 in OA-like Pathogenesis in OsteochondrodysplasiasYefu Li; Fiscal Year: 2010..This study should not only provide novel insights into the role of DDR2 in the progression of genetic forms of OA, but may shed light on aspects of disease progression in non-genetic forms as well. ..
- Pat Levitt; Fiscal Year: 2016..This project includes basic and clinical translational studies that will provide insight into gene- gene and gene-environment interactions that may underlie atypical brain functions in ASD. ..
- The role of the orphan receptor tyrosine kinase Ros1 in vascular diseaseZIAD ANWAR ALI; Fiscal Year: 2011..Thus, understanding how this receptor is activated and identifying the pathways that regulate its function may lead to new therapies for blood vessel disorders - currently the leading killer in the Western World. ..
- Mechanisms of VEGF-A regulated tumor lymphangiogenesisSophia Ran; Fiscal Year: 2007..treatment suppressed expression of three pro- lymphangiogenic mediators: angiopoietin-2 (Ang-2), its receptor Tie-2 and VEGFR-3, a main receptor transmitting VEGF-C signals...
- Novel c-Met and Tie-2 antagonists against human gliomaYouzhi Tong; Fiscal Year: 2007..We found that ANG 797 also targets another receptor tyrosine kinase, Tie-2, involved in angiogenesis and in particular with sustaining tumor neovascularization...
- Cell-based screening for EphA2 receptor inhibitorsElena B Pasquale; Fiscal Year: 2011..Chemical compounds that inhibit EphA2 function will have potential research applications to clarify the role of EphA2 in cancer progression, which is currently not well understood, and therapeutic applications as anti-cancer agents. ..
- Prevention of neointimal thickening by Mst1Junichi Sadoshima; Fiscal Year: 2006..regeneration, we will utilize cell type-specific targeting using tissue specific promoters, including SM22a and Tie-2 promoters...
- Functional role of Angiopoietin-2 in diabetic heartJian xiong Chen; Fiscal Year: 2007..b>Tie-2 is an endothelial- specific receptor tyrosine kinase...
- Analysis of the Novel Kinase ROR2: A New Molecular Target in Renal Cell CarcinomaTricia M Wright; Fiscal Year: 2010..The long term goal of this study is not only to analyze the importance of ROR2 in RCC but also to use the gained knowledge of ROR2 function in the hopes of finding inhibitors that can be used clinically for treating RCC. ..
- ENDOTHELIAL SIGNAL TRANSDUCTION BY TEK AND TIEChristopher Kontos; Fiscal Year: 2001..have demonstrated essential, nonoverlapping roles for the endothelium-specific receptor tyrosine kinases (RTKs) Tie-1 and Tek (also known as Tie-2) in embryonic vascular development...
- Role of receptor tyrosine kinase signaling in branching morphogenesisPENGFEI PAUL LU; Fiscal Year: 2010..If deregulation of RTK signaling could be prevented then we would greatly improve therapeutic interventions of human congenital illnesses inflicting the above epithelial organs and save the lives of millions of patients. ..