TIE1

Summary

Gene Symbol: TIE1
Description: tyrosine kinase with immunoglobulin like and EGF like domains 1
Alias: JTK14, TIE, tyrosine-protein kinase receptor Tie-1, tyrosine kinase with immunoglobulin and epidermal growth factor homology domains 1
Species: human
Products:     TIE1

Top Publications

  1. Marron M, Hughes D, Edge M, Forder C, Brindle N. Evidence for heterotypic interaction between the receptor tyrosine kinases TIE-1 and TIE-2. J Biol Chem. 2000;275:39741-6 pubmed
    The orphan receptor tyrosine kinase Tie-1 is expressed in endothelial cells and is essential for vascular development. Nothing is known about the signaling pathways utilized by this receptor...
  2. Kontos C, Cha E, York J, Peters K. The endothelial receptor tyrosine kinase Tie1 activates phosphatidylinositol 3-kinase and Akt to inhibit apoptosis. Mol Cell Biol. 2002;22:1704-13 pubmed
    b>Tie1 is an orphan receptor tyrosine kinase that is expressed almost exclusively in endothelial cells and that is required for normal embryonic vascular development...
  3. Tsiamis A, Morris P, Marron M, Brindle N. Vascular endothelial growth factor modulates the Tie-2:Tie-1 receptor complex. Microvasc Res. 2002;63:149-58 pubmed
    The receptor tyrosine kinase Tie-1 is expressed predominantly in endothelial cells where it physically associates with the related receptor Tie-2...
  4. Marron M, Singh H, Tahir T, Kavumkal J, Kim H, Koh G, et al. Regulated proteolytic processing of Tie1 modulates ligand responsiveness of the receptor-tyrosine kinase Tie2. J Biol Chem. 2007;282:30509-17 pubmed
    ..The receptor-tyrosine kinase Tie1 is known to undergo ectodomain cleavage generating a membrane-tethered endodomain...
  5. Singh H, Hansen T, Patel N, Brindle N. The molecular balance between receptor tyrosine kinases Tie1 and Tie2 is dynamically controlled by VEGF and TNFα and regulates angiopoietin signalling. PLoS ONE. 2012;7:e29319 pubmed publisher
    Angiopoietin-1 (Ang1) signals via the receptor tyrosine kinase Tie2 which exists in complex with the related protein Tie1 at the endothelial cell surface...
  6. Partanen J, Armstrong E, Mäkelä T, Korhonen J, Sandberg M, Renkonen R, et al. A novel endothelial cell surface receptor tyrosine kinase with extracellular epidermal growth factor homology domains. Mol Cell Biol. 1992;12:1698-707 pubmed
    ..Here we describe the cloning and characterization of tie, a novel type of human endothelial cell surface receptor tyrosine kinase...
  7. Dong L, Lei D, Zhang H. Clinical strategies for acquired epidermal growth factor receptor tyrosine kinase inhibitor resistance in non-small-cell lung cancer patients. Oncotarget. 2017;8:64600-64606 pubmed publisher
    ..This review focuses on improved anticancer agents and therapy options for NSCLC patients with acquired EGFR TKI resistance...
  8. Du Y, Liu J, Tang J, Ge J, Chen Y, Cheng K, et al. Acquired tumor cell resistance to sunitinib by increased invasion and epithelial-mesenchymal transition in LL/2 murine lung cancer. Oncotarget. 2017;8:68270-68279 pubmed publisher
    ..This study aims to investigate biological behavior changes in a murine lung cancer cell characterized by acquired resistance to sunitinib, a potent inhibitor of multiple-targeted receptor tyrosine kinase...
  9. Tanaka M, Yoshimoto T, Nakamura T. A double-edged sword: The world according to Capicua in cancer. Cancer Sci. 2017;: pubmed publisher
    ..These data reveal the importance of CIC as a key molecule in signal transduction, carcinogenesis, and developing novel therapies...
  10. Zeng L, Kang R, Zhu S, Wang X, Cao L, Wang H, et al. ALK is a therapeutic target for lethal sepsis. Sci Transl Med. 2017;9: pubmed publisher
    ..These findings uncover a key role for ALK in modulating the inflammatory signaling pathway and shed light on the development of ALK-targeting therapeutics for lethal systemic inflammatory disorders...

Detail Information

Publications62

  1. Marron M, Hughes D, Edge M, Forder C, Brindle N. Evidence for heterotypic interaction between the receptor tyrosine kinases TIE-1 and TIE-2. J Biol Chem. 2000;275:39741-6 pubmed
    The orphan receptor tyrosine kinase Tie-1 is expressed in endothelial cells and is essential for vascular development. Nothing is known about the signaling pathways utilized by this receptor...
  2. Kontos C, Cha E, York J, Peters K. The endothelial receptor tyrosine kinase Tie1 activates phosphatidylinositol 3-kinase and Akt to inhibit apoptosis. Mol Cell Biol. 2002;22:1704-13 pubmed
    b>Tie1 is an orphan receptor tyrosine kinase that is expressed almost exclusively in endothelial cells and that is required for normal embryonic vascular development...
  3. Tsiamis A, Morris P, Marron M, Brindle N. Vascular endothelial growth factor modulates the Tie-2:Tie-1 receptor complex. Microvasc Res. 2002;63:149-58 pubmed
    The receptor tyrosine kinase Tie-1 is expressed predominantly in endothelial cells where it physically associates with the related receptor Tie-2...
  4. Marron M, Singh H, Tahir T, Kavumkal J, Kim H, Koh G, et al. Regulated proteolytic processing of Tie1 modulates ligand responsiveness of the receptor-tyrosine kinase Tie2. J Biol Chem. 2007;282:30509-17 pubmed
    ..The receptor-tyrosine kinase Tie1 is known to undergo ectodomain cleavage generating a membrane-tethered endodomain...
  5. Singh H, Hansen T, Patel N, Brindle N. The molecular balance between receptor tyrosine kinases Tie1 and Tie2 is dynamically controlled by VEGF and TNFα and regulates angiopoietin signalling. PLoS ONE. 2012;7:e29319 pubmed publisher
    Angiopoietin-1 (Ang1) signals via the receptor tyrosine kinase Tie2 which exists in complex with the related protein Tie1 at the endothelial cell surface...
  6. Partanen J, Armstrong E, Mäkelä T, Korhonen J, Sandberg M, Renkonen R, et al. A novel endothelial cell surface receptor tyrosine kinase with extracellular epidermal growth factor homology domains. Mol Cell Biol. 1992;12:1698-707 pubmed
    ..Here we describe the cloning and characterization of tie, a novel type of human endothelial cell surface receptor tyrosine kinase...
  7. Dong L, Lei D, Zhang H. Clinical strategies for acquired epidermal growth factor receptor tyrosine kinase inhibitor resistance in non-small-cell lung cancer patients. Oncotarget. 2017;8:64600-64606 pubmed publisher
    ..This review focuses on improved anticancer agents and therapy options for NSCLC patients with acquired EGFR TKI resistance...
  8. Du Y, Liu J, Tang J, Ge J, Chen Y, Cheng K, et al. Acquired tumor cell resistance to sunitinib by increased invasion and epithelial-mesenchymal transition in LL/2 murine lung cancer. Oncotarget. 2017;8:68270-68279 pubmed publisher
    ..This study aims to investigate biological behavior changes in a murine lung cancer cell characterized by acquired resistance to sunitinib, a potent inhibitor of multiple-targeted receptor tyrosine kinase...
  9. Tanaka M, Yoshimoto T, Nakamura T. A double-edged sword: The world according to Capicua in cancer. Cancer Sci. 2017;: pubmed publisher
    ..These data reveal the importance of CIC as a key molecule in signal transduction, carcinogenesis, and developing novel therapies...
  10. Zeng L, Kang R, Zhu S, Wang X, Cao L, Wang H, et al. ALK is a therapeutic target for lethal sepsis. Sci Transl Med. 2017;9: pubmed publisher
    ..These findings uncover a key role for ALK in modulating the inflammatory signaling pathway and shed light on the development of ALK-targeting therapeutics for lethal systemic inflammatory disorders...
  11. Hossein G, Arabzadeh S, Salehi Dulabi Z, Dehghani Ghobadi Z, Heidarian Y, Talebi Juybari M. Wnt5A regulates the expression of ROR2 tyrosine kinase receptor in ovarian cancer cells. Biochem Cell Biol. 2017;95:609-615 pubmed publisher
    ..05; r = 0.38). This is the first report to show the regulatory role of Wnt5A on ROR2 expression in ovarian cancer...
  12. Xu L, Chen Y, Dutra Clarke M, Mayakonda A, Hazawa M, Savinoff S, et al. BCL6 promotes glioma and serves as a therapeutic target. Proc Natl Acad Sci U S A. 2017;114:3981-3986 pubmed publisher
    ..Together, these findings uncover a glioma-promoting role of BCL6 and provide the rationale of targeting BCL6 as a potential therapeutic approach...
  13. Lin W, Li A, Chi C, Chung W, Huang C, Lui W, et al. tie-1 protein tyrosine kinase: a novel independent prognostic marker for gastric cancer. Clin Cancer Res. 1999;5:1745-51 pubmed
    ..We have identified 17 PTKs from a gastric adenocarcinoma. Two receptor PTKs, tie-1 and axl, were selected for in situ immunohistochemistry studies because of their higher expression level and ..
  14. Yang P, Chen N, Yang D, Crane J, Huang B, Dong R, et al. Cervical cancer cell-derived angiopoietins promote tumor progression. Tumour Biol. 2017;39:1010428317711658 pubmed publisher
    ..In this study, we found that angiopoietins and Tie receptors were highly expressed in cervical cancer cells...
  15. Kumar B, Chandran B. KSHV Entry and Trafficking in Target Cells-Hijacking of Cell Signal Pathways, Actin and Membrane Dynamics. Viruses. 2016;8: pubmed
    ....
  16. Schille C, Bayerlová M, Bleckmann A, Schambony A. Ror2 signaling is required for local upregulation of GDF6 and activation of BMP signaling at the neural plate border. Development. 2016;143:3182-94 pubmed publisher
    ..Thereby, Ror2 links Wnt/planar cell polarity signaling to BMP signaling in neural plate border specification and neural crest induction...
  17. Al Fayyadh M, Hassan R, Tran Z, Kempenich J, Bunegin L, Dent D, et al. Immediate Auditory Feedback is Superior to Other Types of Feedback for Basic Surgical Skills Acquisition. J Surg Educ. 2017;: pubmed publisher
    ..Sixty-nine first- and second-year medical students were taught to tie 2-handed knots. All participants completed 3 pretest knot-tying trials without feedback...
  18. Ali A, Gale R, Shakoori A. Detection of FLT3/TKD and IDH1 Mutations in Pakistani Acute Myeloid Leukemia Patients by Denaturing HPLC. J Cell Biochem. 2017;118:1174-1181 pubmed publisher
    ..In conclusion, the overall incidence of all these mutations in Pakistani patients was within the globally reported ranges. J. Cell. Biochem. 118: 1174-1181, 2017. © 2016 Wiley Periodicals, Inc...
  19. Mehler W, Keough M, Pettigrove V. Development of whole-sediment toxicity identification and evaluation (TIE) techniques for two Australian freshwater species: Chironomus tepperi and Austrochiltonia subtenuis. Environ Toxicol Chem. 2017;36:2476-2484 pubmed publisher
    ..Environ Toxicol Chem 2017;36:2476-2484. © 2017 SETAC...
  20. Lee E, Ji K, Kim E, Kim S, Song H, Choi H, et al. Blockade of Axl signaling ameliorates HPV16E6-mediated tumorigenecity of cervical cancer. Sci Rep. 2017;7:5759 pubmed publisher
    ..Taken together, Axl expression was induced by HPV16E6 in cervical cancer cells, suggesting that blockade of Axl signalling might be an effective way to reduce the progression of cervical cancer. ..
  21. Deng J, Yuan Q, Wang M, Yang Y. [Effect of Acupuncture on Expression of Receptor Tyrosine Kinase c-kit in Interstitial Cells of Cajal, Carbon Monoxide and Heme Oxygenase in Colon Tissue After Colonic Anastomosis in Rats]. Zhen Ci Yan Jiu. 2017;42:296-301 pubmed
    ....
  22. Yao Z, Yaeger R, Rodrik Outmezguine V, Tao A, Torres N, Chang M, et al. Tumours with class 3 BRAF mutants are sensitive to the inhibition of activated RAS. Nature. 2017;548:234-238 pubmed publisher
    ..We have thus defined three distinct functional classes of BRAF mutants in human tumours. The mutants activate ERK signalling by different mechanisms that dictate their sensitivity to therapeutic inhibitors of the pathway...
  23. Mo H, Liu P. Targeting MET in cancer therapy. Chronic Dis Transl Med. 2017;3:148-153 pubmed publisher
    ..In hepatocellular carcinoma, based on the encouraging results of some phase II studies, a series of phase III trials are currently recruiting patients to access the efficacy and safety of MET inhibitors...
  24. Liefers Visser J, Meijering R, Reyners A, van der Zee A, de Jong S. IGF system targeted therapy: Therapeutic opportunities for ovarian cancer. Cancer Treat Rev. 2017;60:90-99 pubmed publisher
    ..Multiple-targeted approaches circumventing bidirectional receptor tyrosine kinase (RTK) compensation and prevention of system rewiring are expected to have more therapeutic potential. ..
  25. Almodóvar K, Iams W, Meador C, Zhao Z, York S, Horn L, et al. Longitudinal Cell-Free DNA Analysis in Patients with Small Cell Lung Cancer Reveals Dynamic Insights into Treatment Efficacy and Disease Relapse. J Thorac Oncol. 2017;: pubmed publisher
    ....
  26. Schiller J. Adjuvant systemic therapies in early-stage non-small-cell lung cancer. Clin Lung Cancer. 2003;5 Suppl 1:S29-35 pubmed
    ..A combination of these new approaches and standard therapy for NSCLC may improve long-term survival in patients with lung cancer..
  27. Uozu S, Imaizumi K, Yamaguchi T, Goto Y, Kawada K, Minezawa T, et al. Feasibility of tissue re-biopsy in non-small cell lung cancers resistant to previous epidermal growth factor receptor tyrosine kinase inhibitor therapies. BMC Pulm Med. 2017;17:175 pubmed publisher
    ..However, the process of TKI-sensitive tumor re-progression and whether re-biopsy is possible in all cases of acquired resistance to EGFR-TKI remain unclear...
  28. Landry M, Pomerleau V, Saucier C. Non-canonical dynamic mechanisms of interaction between the p66Shc protein and Met receptor. Biochem J. 2016;473:1617-27 pubmed publisher
    ....
  29. Jeong H, Phan A, Choi J. Anti-cancer Effects of Polyphenolic Compounds in Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor-resistant Non-small Cell Lung Cancer. Pharmacogn Mag. 2017;13:595-599 pubmed publisher
    ....
  30. Higgins S, Purcell L, Silver K, Tran V, Crowley V, Hawkes M, et al. Dysregulation of angiopoietin-1 plays a mechanistic role in the pathogenesis of cerebral malaria. Sci Transl Med. 2016;8:358ra128 pubmed publisher
    ..Microvascular leak plays an important role in the pathogenesis of cerebral malaria. The angiopoietin (Ang)-Tie-2 system is a critical regulator of vascular function...
  31. Trenker R, Call M, Call M. Progress and prospects for structural studies of transmembrane interactions in single-spanning receptors. Curr Opin Struct Biol. 2016;39:115-123 pubmed publisher
    ....
  32. Testa U, Castelli G, Pelosi E. Esophageal Cancer: Genomic and Molecular Characterization, Stem Cell Compartment and Clonal Evolution. Medicines (Basel). 2017;4: pubmed publisher
    ..The reviewed studies suggest that current molecular and cellular characterization of EAC and ESCC should serve as background for development of new treatment strategies. ..
  33. Zenke Y, Umemura S, Sugiyama E, Kirita K, Matsumoto S, Yoh K, et al. Successful treatment with afatinib after grade 3 hepatotoxicity induced by both gefitinib and erlotinib in EGFR mutation-positive non-small cell lung cancer. Lung Cancer. 2016;99:1-3 pubmed publisher
    ..We describe successful management of the patient's tumor by switching to afatinib. Evaluation of single nucleotide polymorphisms (SNPs) in metabolic enzymes might be useful to predict severe hepatotoxicity induced by EGFR-TKIs. ..
  34. Kulkarni R, Stuart W, Waltz S. Ron receptor-dependent gene regulation of Kupffer cells during endotoxemia. Hepatobiliary Pancreat Dis Int. 2014;13:281-92 pubmed
    ....
  35. Kampa Schittenhelm K, Frey J, Haeusser L, Illing B, Pavlovsky A, Blumenstock G, et al. Crenolanib is a type I tyrosine kinase inhibitor that inhibits mutant KIT D816 isoforms prevalent in systemic mastocytosis and core binding factor leukemia. Oncotarget. 2017;8:82897-82909 pubmed publisher
    ..In conclusion, we demonstrate that crenolanib is an inhibitor of mutant-KIT D816 isoforms at clinically achievable concentrations, and thus may be a potential treatment for SM and CBF AML as a monotherapy or in combination approaches...
  36. Zhong J, Li L, Wang Z, Bai H, Gai F, Duan J, et al. Potential Resistance Mechanisms Revealed by Targeted Sequencing from Lung Adenocarcinoma Patients with Primary Resistance to Epidermal Growth Factor Receptor (EGFR) Tyrosine Kinase Inhibitors (TKIs). J Thorac Oncol. 2017;12:1766-1778 pubmed publisher
    ..Mutations in EGFR and its downstream pathway, as well as mutations that affect tumor cell function, are related to primary resistance. Somatic single-nucleotide mutation patterns might be associated with primary resistance to EGFR TKIs. ..
  37. Cai J, Sun M, Ge X, Sun Y. EGFR tyrosine kinase inhibitors differentially affect autophagy in head and neck squamous cell carcinoma. Biochem Biophys Res Commun. 2017;486:1027-1033 pubmed publisher
    ..Blocking the initiation of autophagy does not affect the second-generation EGFR TKI-induced HNSCC growth suppression. This suggests that the anti-growth effect of the second-generation EGFR TKIs on HNSCC is not dependent on autophagy...
  38. Knittle A, Helkkula M, Johnson M, Sundvall M, Elenius K. Sumoylation regulates nuclear accumulation and signaling activity of the soluble intracellular domain of the erbb4 receptor tyrosine kinase. J Biol Chem. 2017;: pubmed publisher
    ..Our findings indicate that a SUMOylation-mediated mechanism regulates nuclear localization and function of the ICD of ErbB4 receptor tyrosine kinase...
  39. Bryson P, Han X, Truong N, Wang P. Breast cancer vaccines delivered by dendritic cell-targeted lentivectors induce potent antitumor immune responses and protect mice from mammary tumor growth. Vaccine. 2017;35:5842-5849 pubmed publisher
    ..Furthermore, they could be combined with other immunotherapeutic regimens to improve outcomes for patients with breast cancer. ..
  40. Zhang X, Ji J, Zhang G, Fang C, Jiang F, Ma S, et al. Expression and significance of B7-H3 and Tie-2 in the tumor vasculature of clear cell renal carcinoma. Onco Targets Ther. 2017;10:5417-5424 pubmed publisher
    Tumor angiogenesis is required for tumor growth and metastasis, and the Ang/Tie-2 axis plays a pivotal role in angiogenesis...
  41. Tian Y, Li Y, Li J, Feng S, Li S, Mao J, et al. Bufei Yishen Granules Combined with Acupoint Sticking Therapy Suppress Inflammation in Chronic Obstructive Pulmonary Disease Rats: Via JNK/p38 Signaling Pathway. Evid Based Complement Alternat Med. 2017;2017:1768243 pubmed publisher
    ..to explore the mechanism of the effects of Bufei Yishen granules combined with acupoint sticking therapy (Shu-Fei Tie) on inflammation regulated by c-Jun N-terminal kinase (JNK) and p38 MAPK signaling in COPD rats...
  42. Unsal D, Kacan M, Temiz Resitoglu M, Guden D, Korkmaz B, Sari A, et al. The role of Syk/IĸB-α/NF-ĸB pathway activation in the reversal effect of BAY 61-3606, a selective Syk inhibitor, on hypotension and inflammation in a rat model of zymosan-induced non-septic shock. Clin Exp Pharmacol Physiol. 2017;: pubmed publisher
    ..These results suggest that Syk/IĸB-α/NF-ĸB pathway activation contributes to hypotension and inflammation caused by the production of vasodilator and proinflammatory mediators in the zymosan-induced non-septic shock model...
  43. Kanzaki R, Naito H, Kise K, Takara K, Eino D, Minami M, et al. Gas6 derived from cancer-associated fibroblasts promotes migration of Axl-expressing lung cancer cells during chemotherapy. Sci Rep. 2017;7:10613 pubmed publisher
    ..9% vs 51.3%, p = 0.04). Based on these findings, it is presumed that Gas6 derived from CAFs promotes migration of Axl-expressing lung cancer cells during chemotherapy and is involved in poor clinical outcome. ..
  44. Lin J, Shaw A. Recent Advances in Targeting ROS1 in Lung Cancer. J Thorac Oncol. 2017;12:1611-1625 pubmed publisher
    ..This review discusses the biology and diagnosis of ROS1-rearranged NSCLC, and current and emerging treatment options for this disease. Future challenges in the field are highlighted. ..
  45. Ramachandra C, Mehta A, Lua C, Chitre A, Ja K, Shim W. ErbB Receptor Tyrosine Kinase: A Molecular Switch Between Cardiac and Neuroectoderm Specification in Human Pluripotent Stem Cells. Stem Cells. 2016;34:2461-2470 pubmed publisher
    ..Forced overexpression of ErbB4 rescued cardiac commitment by augmenting Wnt11 signaling. Convergence between EGFR/ErbB4 and canonical/noncanonical Wnt signaling determines cardiogenic fate in hPSCs. Stem Cells 2016;34:2461-2470...
  46. Barrows D, He J, Parsons R. PREX1 Protein Function Is Negatively Regulated Downstream of Receptor Tyrosine Kinase Activation by p21-activated Kinases (PAKs). J Biol Chem. 2016;291:20042-54 pubmed publisher
    ..Our data point to multiple mechanisms of PREX1 negative regulation by PAKs within receptor tyrosine kinase and GPCR-stimulated signaling pathways that have important roles in diseases such as diabetes and cancer...
  47. Sherbet G. Suppression of angiogenesis and tumour progression by combretastatin and derivatives. Cancer Lett. 2017;403:289-295 pubmed publisher
    ..It is essential to establish the perceived inhibition of EMT beyond reasonable doubt. This might justify using the combretastatins with allosteric EMT and Akt inhibitors as additional choices for pre-clinical/clinical studies. ..
  48. Chang S, Hur J, Hong Y, Lee H, Kim Y, Han K, et al. Adverse Prognostic CT Findings for Patients With Advanced Lung Adenocarcinoma Receiving First-Line Epidermal Growth Factor Receptor-Tyrosine Kinase Inhibitor Therapy. AJR Am J Roentgenol. 2017;:1-9 pubmed publisher
    ....
  49. Sarabipour S. Parallels and Distinctions in FGFR, VEGFR, and EGFR Mechanisms of Transmembrane Signaling. Biochemistry. 2017;56:3159-3173 pubmed publisher
    ..These insights reveal distinct steps in and factors of RTK signaling across the plasma membrane that can guide the drug discovery process for RTK targeting therapeutics...
  50. Kitazono T, Hara Kuge S, Matsuda O, Inoue A, Fujiwara M, Ishihara T. Multiple Signaling Pathways Coordinately Regulate Forgetting of Olfactory Adaptation through Control of Sensory Responses in Caenorhabditis elegans. J Neurosci. 2017;37:10240-10251 pubmed publisher
    ..We suggest that multiple pathways may coordinately and temporally regulate forgetting through control of sensory responses. This study should lead to a better understanding of forgetting in higher organisms. ..
  51. Galetta D, Catino A, Misino A, De Ceglie A, Logroscino A, Simone G, et al. Bladder and gastric metastases from lung adenocarcinoma harboring codon 13 KRAS mutation: a case report with unusual clinical outcome. Tumori. 2015;101:e138-40 pubmed publisher
    ..In this report, the authors describe a case of lung adenocarcinoma harboring a codon 13 KRAS mutation detected in all the biopsies performed in unusual metastatic sites during an atypical disease course...
  52. Dutton J, Chen H, You C, Brodie M, Lasek A. Anaplastic lymphoma kinase regulates binge-like drinking and dopamine receptor sensitivity in the ventral tegmental area. Addict Biol. 2017;22:665-678 pubmed publisher
    ..These data support the possibility that ALK might be a novel target of pharmacotherapy for reducing excessive alcohol consumption...
  53. Chen K, Yu X, Wang H, Huang Z, Xu Y, Gong L, et al. Uncommon mutation types of epidermal growth factor receptor and response to EGFR tyrosine kinase inhibitors in Chinese non-small cell lung cancer patients. Cancer Chemother Pharmacol. 2017;80:1179-1187 pubmed publisher
    ..However, the efficacy of EGFR-TKIs in patients with uncommon EGFR mutations (other than exon 19 deletions or exon 21 L858R mutation) remains undetermined...
  54. Rafferty N. Effects of global change on insect pollinators: multiple drivers lead to novel communities. Curr Opin Insect Sci. 2017;23:22-27 pubmed publisher
    ..Genetic analyses tie bee fitness to habitat quality. Across drivers, novel communities are a common outcome that deserves more study.
  55. Dearing J, Beacom A, Chamberlain S, Meng J, Berta W, Keefe J, et al. Pathways for best practice diffusion: the structure of informal relationships in Canada's long-term care sector. Implement Sci. 2017;12:11 pubmed publisher
    ..We sought to identify existing influence throughout Canada's long-term care sector and the extent to which informal advice-seeking relationships tie the sector together as a network.
  56. Pierce E, Bloodworth C, Siefert A, Easley T, Takayama T, Kawamura T, et al. Mitral annuloplasty ring suture forces: Impact of surgeon, ring, and use conditions. J Thorac Cardiovasc Surg. 2017;: pubmed publisher
    ..to quantify the effect of ring type, ring-annulus sizing, suture position, and surgeon on the forces required to tie down and constrain a mitral annuloplasty ring to a beating heart...
  57. Vanli G, Cuesta Marbán A, Widmann C. Evaluation and validation of commercial antibodies for the detection of Shb. PLoS ONE. 2017;12:e0188311 pubmed publisher
    ..This article provides a resource for the available molecular tools that can be used in future research on Shb...
  58. von Suesskind Schwendi M, Boxhammer E, Hirt S, Schreml S, Schmid C, Wollin L, et al. The activity of nintedanib in an animal model of allogenic left lung transplantation resembling aspects of allograft rejection. Exp Lung Res. 2017;43:259-270 pubmed publisher
    ..Growth factors may play an important role in the development of CLAD. This study evaluated the effects of nintedanib, a receptor tyrosine kinase inhibitor, in the treatment of CLAD after experimental LTx...
  59. Dickinson S, Sutton C, Brady K, Salerno A, Katopodi T, Williams R, et al. The Wnt5a Receptor, Receptor Tyrosine Kinase-Like Orphan Receptor 2, Is a Predictive Cell Surface Marker of Human Mesenchymal Stem Cells with an Enhanced Capacity for Chondrogenic Differentiation. Stem Cells. 2017;35:2280-2291 pubmed publisher
    ..We conclude that MSCs expressing high levels of ROR2 provide a defined population capable of predictably enhanced cartilage production. Stem Cells 2017;35:2280-2291...
  60. Rossin A, Lounnas N, Durivault J, Miloro G, Gagnoux Palacios L, Hueber A. The Btk-dependent PIP5K1γ lipid kinase activation by Fas counteracts FasL-induced cell death. Apoptosis. 2017;22:1344-1352 pubmed publisher
    ....