TERT

Summary

Gene Symbol: TERT
Description: telomerase reverse transcriptase
Alias: CMM9, DKCA2, DKCB4, EST2, PFBMFT1, TCS1, TP2, TRT, hEST2, hTRT, telomerase reverse transcriptase, telomerase catalytic subunit, telomerase-associated protein 2
Species: human
Products:     TERT

Top Publications

  1. Renaud S, Loukinov D, Bosman F, Lobanenkov V, Benhattar J. CTCF binds the proximal exonic region of hTERT and inhibits its transcription. Nucleic Acids Res. 2005;33:6850-60 pubmed
    ..Our results suggest that CTCF participates in key cellular mechanisms underlying immortality by regulating hTERT gene expression. ..
  2. Myneni A, Chang S, Niu R, Liu L, Ochs Balcom H, Li Y, et al. Genetic polymorphisms of TERT and CLPTM1L and risk of lung cancer--a case-control study in a Chinese population. Lung Cancer. 2013;80:131-7 pubmed publisher
    Genetic variants of telomerase reverse transcriptase (TERT) and cleft lip and palate trans-membrane 1 like (CLPTM1L) genes in chromosome 5p15.33 region were previously identified to influence the susceptibility to lung cancer...
  3. Calado R, Brudno J, Mehta P, Kovacs J, Wu C, Zago M, et al. Constitutional telomerase mutations are genetic risk factors for cirrhosis. Hepatology. 2011;53:1600-7 pubmed publisher
    ..University of Arizona, between May 2008 and July 2009, and 528 healthy subjects were screened for variation in the TERT and TERC genes by direct sequencing; an additional 1,472 controls were examined for the most common genetic ..
  4. Huang F, Hodis E, Xu M, Kryukov G, Chin L, Garraway L. Highly recurrent TERT promoter mutations in human melanoma. Science. 2013;339:957-9 pubmed publisher
    ..Here, we describe two independent mutations within the core promoter of telomerase reverse transcriptase (TERT), the gene coding for the catalytic subunit of telomerase, which collectively occur in 50 of 70 ..
  5. Haiman C, Chen G, Vachon C, Canzian F, Dunning A, Millikan R, et al. A common variant at the TERT-CLPTM1L locus is associated with estrogen receptor-negative breast cancer. Nat Genet. 2011;43:1210-4 pubmed publisher
    ..We identified a common risk variant for ER-negative breast cancer at the TERT-CLPTM1L locus on chromosome 5p15 (rs10069690: per-allele odds ratio (OR) = 1.18 per allele, P = 1.0 × 10(-10))...
  6. Shen J, Gammon M, Wu H, Terry M, Wang Q, Bradshaw P, et al. Multiple genetic variants in telomere pathway genes and breast cancer risk. Cancer Epidemiol Biomarkers Prev. 2010;19:219-28 pubmed publisher
    ..05. The top three statistically significant SNPs under a dominant model were TERT-07 (rs2736109), TERT-54 (rs3816659), and POT1-03 (rs33964002). The odds ratios (OR) were 1...
  7. Petersen G, Amundadottir L, Fuchs C, Kraft P, Stolzenberg Solomon R, Jacobs K, et al. A genome-wide association study identifies pancreatic cancer susceptibility loci on chromosomes 13q22.1, 1q32.1 and 5p15.33. Nat Genet. 2010;42:224-8 pubmed publisher
    ..71-0.84). A single SNP, rs401681 (P = 3.66 x 10(-7), per-allele OR 1.19, 95% CI 1.11-1.27), maps to the CLPTM1L-TERT locus on 5p15.33, which is associated with multiple cancers...
  8. Hosgood H, Cawthon R, He X, Chanock S, Lan Q. Genetic variation in telomere maintenance genes, telomere length, and lung cancer susceptibility. Lung Cancer. 2009;66:157-61 pubmed publisher
    ..length separately and in conjunction with single nucleotide polymorphisms in the telomere maintenance genes POT1, TERT, and TERF2, which we have previously reported were associated with risk of lung cancer in this study...
  9. Bojesen S, Pooley K, Johnatty S, Beesley J, Michailidou K, Tyrer J, et al. Multiple independent variants at the TERT locus are associated with telomere length and risks of breast and ovarian cancer. Nat Genet. 2013;45:371-84, 384e1-2 pubmed publisher
    b>TERT-locus SNPs and leukocyte telomere measures are reportedly associated with risks of multiple cancers...

More Information

Publications274 found, 100 shown here

  1. Turnbull C, Rapley E, Seal S, Pernet D, Renwick A, Hughes D, et al. Variants near DMRT1, TERT and ATF7IP are associated with testicular germ cell cancer. Nat Genet. 2010;42:604-7 pubmed publisher
    ..We identified two independent signals within the TERT-CLPTM1L locus on chromosome 5, which has previously been associated with multiple other cancers (rs4635969, OR=1...
  2. Fingerlin T, Murphy E, Zhang W, Peljto A, Brown K, Steele M, et al. Genome-wide association study identifies multiple susceptibility loci for pulmonary fibrosis. Nat Genet. 2013;45:613-20 pubmed publisher
    ..We confirmed association with TERT at 5p15, MUC5B at 11p15 and the 3q26 region near TERC, and we identified seven newly associated loci (Pmeta = 2...
  3. Maida Y, Yasukawa M, Okamoto N, Ohka S, Kinoshita K, Totoki Y, et al. Involvement of telomerase reverse transcriptase in heterochromatin maintenance. Mol Cell Biol. 2014;34:1576-93 pubmed publisher
    ..In association with the telomerase RNA component (TERC), the telomerase reverse transcriptase (TERT) forms telomerase and counteracts telomere attrition, and without TERC, TERT has been ..
  4. Heidenreich B, Nagore E, Rachakonda P, Garcia Casado Z, Requena C, Traves V, et al. Telomerase reverse transcriptase promoter mutations in primary cutaneous melanoma. Nat Commun. 2014;5:3401 pubmed publisher
    ..somatic mutations in metastasized tumours from unrelated patients in the core promoter region of the telomerase reverse transcriptase (TERT) gene...
  5. Li Y, Tergaonkar V. Noncanonical functions of telomerase: implications in telomerase-targeted cancer therapies. Cancer Res. 2014;74:1639-44 pubmed publisher
    ..This review summarizes recent insights to the noncanonical functions of telomerase reverse transcriptase (TERT) catalytic subunit, in particular in cancer progression, and highlights two major signaling ..
  6. Heidenreich B, Rachakonda P, Hemminki K, Kumar R. TERT promoter mutations in cancer development. Curr Opin Genet Dev. 2014;24:30-7 pubmed publisher
    Human telomerase reverse transcriptase (TERT) encodes a rate-limiting catalytic subunit of telomerase that maintains genomic integrity...
  7. Pópulo H, Boaventura P, Vinagre J, Batista R, Mendes A, Caldas R, et al. TERT promoter mutations in skin cancer: the effects of sun exposure and X-irradiation. J Invest Dermatol. 2014;134:2251-2257 pubmed publisher
    The reactivation or reexpression of telomerase (TERT) is a widespread feature of neoplasms. TERT promoter mutations were recently reported that were hypothesized to result from UV radiation...
  8. Killela P, Pirozzi C, Healy P, Reitman Z, Lipp E, Rasheed B, et al. Mutations in IDH1, IDH2, and in the TERT promoter define clinically distinct subgroups of adult malignant gliomas. Oncotarget. 2014;5:1515-25 pubmed
    Frequent mutations in isocitrate dehydrogenase 1 and 2 (IDH1 and IDH2) and the promoter of telomerase reverse transcriptase (TERT) represent two significant discoveries in glioma genomics...
  9. Wang N, Liu T, Sofiadis A, Juhlin C, Zedenius J, Höög A, et al. TERT promoter mutation as an early genetic event activating telomerase in follicular thyroid adenoma (FTA) and atypical FTA. Cancer. 2014;120:2965-79 pubmed publisher
    The telomerase reverse transcriptase (TERT) promoter mutations C228T and C250T have been found in many malignancies, including in thyroid carcinomas. However, it is unclear how early these mutations occur in thyroid tumorigenesis...
  10. Xing M, Liu R, Liu X, Murugan A, Zhu G, Zeiger M, et al. BRAF V600E and TERT promoter mutations cooperatively identify the most aggressive papillary thyroid cancer with highest recurrence. J Clin Oncol. 2014;32:2718-26 pubmed publisher
    To investigate the prognostic value of the BRAF V600E mutation and the recently identified TERT promoter mutation chr5:1,295,228C>T (C228T), individually and in their coexistence, in papillary thyroid cancer (PTC)...
  11. Xie H, Liu T, Wang N, Björnhagen V, Höög A, Larsson C, et al. TERT promoter mutations and gene amplification: promoting TERT expression in Merkel cell carcinoma. Oncotarget. 2014;5:10048-57 pubmed
    Telomerase activation through the induction of its catalytic component TERT is essential in carcinogenesis...
  12. Wang K, Liu T, Liu L, Liu J, Liu C, Wang C, et al. TERT promoter mutations in renal cell carcinomas and upper tract urothelial carcinomas. Oncotarget. 2014;5:1829-36 pubmed
    b>TERT promoter mutations are identified in many malignancies including bladder cancer (BC) and upper tract urothelial carcinoma (UTUC). In contrast, no mutations were found in renal cell carcinoma (RCC) as reported in a recent study...
  13. Xi L, Cech T. Inventory of telomerase components in human cells reveals multiple subpopulations of hTR and hTERT. Nucleic Acids Res. 2014;42:8565-77 pubmed publisher
    ..levels of the human telomerase RNP and its two key components, human telomerase RNA (hTR) and human telomerase reverse transcriptase (hTERT)...
  14. Terrin L, Dal Col J, Rampazzo E, Zancai P, Pedrotti M, Ammirabile G, et al. Latent membrane protein 1 of Epstein-Barr virus activates the hTERT promoter and enhances telomerase activity in B lymphocytes. J Virol. 2008;82:10175-87 pubmed publisher
  15. Venteicher A, Abreu E, Meng Z, McCann K, Terns R, Veenstra T, et al. A human telomerase holoenzyme protein required for Cajal body localization and telomere synthesis. Science. 2009;323:644-8 pubmed publisher
    ..Active human telomerase consists of at least three principal subunits, including the telomerase reverse transcriptase, the telomerase RNA (TERC), and dyskerin...
  16. Robart A, Collins K. Investigation of human telomerase holoenzyme assembly, activity, and processivity using disease-linked subunit variants. J Biol Chem. 2010;285:4375-86 pubmed publisher
    ..Structure/function studies of disease-linked variants of human telomerase RNA (hTR) or telomerase reverse transcriptase (TERT) have exploited in vitro reconstitution of the enzyme catalytic core and/or a PCR-amplified ..
  17. Mukherjee S, Firpo E, Wang Y, Roberts J. Separation of telomerase functions by reverse genetics. Proc Natl Acad Sci U S A. 2011;108:E1363-71 pubmed publisher
    ..Thus, enhanced cell proliferation is an independent function of hTERT that could provide a new target for the development of anti-telomerase cancer therapeutic agents. ..
  18. Miller J, Dakic A, Chen R, Palechor Ceron N, Dai Y, Kallakury B, et al. HPV16 E7 protein and hTERT proteins defective for telomere maintenance cooperate to immortalize human keratinocytes. PLoS Pathog. 2013;9:e1003284 pubmed publisher
    Previous studies have shown that wild-type human telomerase reverse transcriptase (hTERT) protein can functionally replace the human papillomavirus type 16 (HPV-16) E6 protein, which cooperates with the viral E7 protein in the ..
  19. Wu R, Ayhan A, Maeda D, Kim K, Clarke B, Shaw P, et al. Frequent somatic mutations of the telomerase reverse transcriptase promoter in ovarian clear cell carcinoma but not in other major types of gynaecological malignancy. J Pathol. 2014;232:473-81 pubmed publisher
    Up-regulated expression of telomerase reverse transcriptase (TERT) and subsequent maintenance of telomere length are essential in tumour development...
  20. Armanios M, Chen J, Cogan J, Alder J, Ingersoll R, Markin C, et al. Telomerase mutations in families with idiopathic pulmonary fibrosis. N Engl J Med. 2007;356:1317-26 pubmed
    ..Germ-line mutations in the genes hTERT and hTR, encoding telomerase reverse transcriptase and telomerase RNA, respectively, cause autosomal dominant dyskeratosis congenita, a rare hereditary ..
  21. Liu Z, Li G, Wei S, Niu J, Wang L, Sturgis E, et al. Genetic variations in TERT-CLPTM1L genes and risk of squamous cell carcinoma of the head and neck. Carcinogenesis. 2010;31:1977-81 pubmed publisher
    Single-nucleotide polymorphisms (SNPs) of TERT-rs2736098 (C > T) and CLPTM1L-rs401681(C > T) at the 5p15...
  22. Lee S, Kim J, Lee H, Cho Y, Oh S, Kim Y, et al. Interferon regulatory factor-1 (IRF-1) is a mediator for interferon-gamma induced attenuation of telomerase activity and human telomerase reverse transcriptase (hTERT) expression. Oncogene. 2003;22:381-91 pubmed
    ..In this study, we show that IFN-gamma signaling represses telomerase activity and human telomerase reverse transcriptase (hTERT) transcription, and suggest that this signaling is mediated by IRF-1...
  23. Armbruster B, Linardic C, Veldman T, Bansal N, Downie D, Counter C. Rescue of an hTERT mutant defective in telomere elongation by fusion with hPot1. Mol Cell Biol. 2004;24:3552-61 pubmed
    ..However, this rescue depended on the ability of hPot1 to localize to telomeres rather than binding to DNA per se. These data support a model whereby the DAT domain of hTERT is implicated in telomere-telomerase associations. ..
  24. Beattie T, Zhou W, Robinson M, Harrington L. Polymerization defects within human telomerase are distinct from telomerase RNA and TEP1 binding. Mol Biol Cell. 2000;11:3329-40 pubmed
    ..core of human telomerase is postulated to contain two components, the telomerase RNA hTER and the telomerase reverse transcriptase hTERT...
  25. Xu M, Luo W, Elzi D, Grandori C, Galloway D. NFX1 interacts with mSin3A/histone deacetylase to repress hTERT transcription in keratinocytes. Mol Cell Biol. 2008;28:4819-28 pubmed publisher
    ..These data demonstrate that targeted degradation of NFX1-91 by E6/E6AP dissociates the mSin3A/HDAC complex from the hTERT promoter and induces hTERT transcription. ..
  26. Harrington L, Zhou W, McPhail T, Oulton R, Yeung D, Mar V, et al. Human telomerase contains evolutionarily conserved catalytic and structural subunits. Genes Dev. 1997;11:3109-15 pubmed
    We have cloned and characterized a human gene encoding TP2 (telomerase-associated protein 2), a protein with similarity to reverse transcriptases and the catalytic telomerase subunits from Saccharomyces cerevisiae and Euplotes ..
  27. Anderson C, Hoare S, Ashcroft M, Bilsland A, Keith W. Hypoxic regulation of telomerase gene expression by transcriptional and post-transcriptional mechanisms. Oncogene. 2006;25:61-9 pubmed
    ..These studies show that hTERT and hTR are subject to similar controls under hypoxia and highlight the rapid and dynamic regulation of the telomerase genes in vivo. ..
  28. D Souza Y, Chu T, Autexier C. A translocation-defective telomerase with low levels of activity and processivity stabilizes short telomeres and confers immortalization. Mol Biol Cell. 2013;24:1469-79 pubmed publisher
    ..G-rich telomeric sequences are synthesized by telomerase, a ribonucleoprotein consisting of telomerase reverse transcriptase (TERT) and an integrally associated RNA...
  29. Zaug A, Crary S, Jesse Fioravanti M, Campbell K, Cech T. Many disease-associated variants of hTERT retain high telomerase enzymatic activity. Nucleic Acids Res. 2013;41:8969-78 pubmed publisher
    Mutations in the gene for telomerase reverse transcriptase (hTERT) are associated with diseases including dyskeratosis congenita, aplastic anemia, pulmonary fibrosis and cancer...
  30. Wang L, Soria J, Chang Y, Lee H, Wei Q, Mao L. Association of a functional tandem repeats in the downstream of human telomerase gene and lung cancer. Oncogene. 2003;22:7123-9 pubmed
    ..18; 95% confidence interval=0.92, 5.20) after adjustment for age, sex, ethnicity, and smoking status, suggesting a potential role of MNS16A in lung cancer susceptibility. Larger studies are needed to verify our findings. ..
  31. Kohno T, Kunitoh H, Shimada Y, Shiraishi K, Ishii Y, Goto K, et al. Individuals susceptible to lung adenocarcinoma defined by combined HLA-DQA1 and TERT genotypes. Carcinogenesis. 2010;31:834-41 pubmed publisher
    ..DQA1*03 and the minor allele for a polymorphism, rs2736100, in TERT, another lung cancer susceptibility locus identified in recent GWASs on Europeans and Americans, were indicated to ..
  32. Kovalenko O, Caron M, Ulema P, Medrano C, Thomas A, Kimura M, et al. A mutant telomerase defective in nuclear-cytoplasmic shuttling fails to immortalize cells and is associated with mitochondrial dysfunction. Aging Cell. 2010;9:203-19 pubmed publisher
  33. Takakura M, Kyo S, Kanaya T, Hirano H, Takeda J, Yutsudo M, et al. Cloning of human telomerase catalytic subunit (hTERT) gene promoter and identification of proximal core promoter sequences essential for transcriptional activation in immortalized and cancer cells. Cancer Res. 1999;59:551-7 pubmed
    ..Of the three major subunits comprising human telomerase, human telomerase catalytic subunit (hTERT) has been shown to be a rate-limiting determinant of the enzymatic activity of human telomerase...
  34. Holt S, Glinsky V, Ivanova A, Glinsky G. Resistance to apoptosis in human cells conferred by telomerase function and telomere stability. Mol Carcinog. 1999;25:241-8 pubmed
    ..Taken together, these results provide the first direct experimental evidence supporting the hypothesis that telomerase activity and maintenance of telomere stability are associated with increased cellular resistance to apoptosis. ..
  35. Osterhage J, Friedman K. Chromosome end maintenance by telomerase. J Biol Chem. 2009;284:16061-5 pubmed publisher
    ..This minireview provides an overview of telomerase structure, function, and regulation and the role of telomerase in human disease. ..
  36. Zhang R, Zhao J, Yang L, Yang S, Wang R, Chen W, et al. RNA interference-mediated hTERT inhibition enhances TRAIL-induced apoptosis in resistant hepatocellular carcinoma cells. Oncol Rep. 2010;23:1013-9 pubmed
    ..It has been shown that human telomerase catalytic subunit (hTERT) is overexpressed in human HCCs...
  37. Won J, Yim J, Kim T. Sp1 and Sp3 recruit histone deacetylase to repress transcription of human telomerase reverse transcriptase (hTERT) promoter in normal human somatic cells. J Biol Chem. 2002;277:38230-8 pubmed
    ..cells, telomerase activity is tightly regulated by the expression of its catalytic subunit, human telomerase reverse transcriptase (hTERT)...
  38. Agarwal M, Pandita S, Hunt C, Gupta A, Yue X, Khan S, et al. Inhibition of telomerase activity enhances hyperthermia-mediated radiosensitization. Cancer Res. 2008;68:3370-8 pubmed publisher
    ..in enhanced hyperthermia-mediated IR-induced cell killing, and ectopic expression of catalytic unit of telomerase (TERT) decreased hyperthermia-mediated IR-induced cell killing...
  39. Catarino R, Araujo A, Coelho A, Gomes M, Nogueira A, Lopes C, et al. Prognostic significance of telomerase polymorphism in non-small cell lung cancer. Clin Cancer Res. 2010;16:3706-12 pubmed publisher
    ..The assessment of telomerase genetic variants could supplement prognosis of survival in the course of NSCLC and may be a promising molecular marker of treatment response in these patients. ..
  40. Won J, Yim J, Kim T. Opposing regulatory roles of E2F in human telomerase reverse transcriptase (hTERT) gene expression in human tumor and normal somatic cells. FASEB J. 2002;16:1943-5 pubmed
    ..Telomerase activity is tightly regulated by the expression of its catalytic subunit human telomerase reverse transcriptase (hTERT)...
  41. Melissourgos N, Kastrinakis N, Davilas I, Foukas P, Farmakis A, Lykourinas M. Detection of human telomerase reverse transcriptase mRNA in urine of patients with bladder cancer: evaluation of an emerging tumor marker. Urology. 2003;62:362-7 pubmed
    ..detection marker, we investigated the expression of the catalytic subunit of the complex (human telomerase reverse transcriptase [hTERT]) in the urine of patients with malignant or benign urinary lesions, as well as of healthy ..
  42. Yamaguchi H, Calado R, Ly H, Kajigaya S, Baerlocher G, Chanock S, et al. Mutations in TERT, the gene for telomerase reverse transcriptase, in aplastic anemia. N Engl J Med. 2005;352:1413-24 pubmed
    ..cause an amino acid change in the corresponding protein) were identified in TERT, the gene for the telomerase reverse transcriptase catalytic enzyme, among seven unrelated patients...
  43. Deng W, Jayachandran G, Wu G, Xu K, Roth J, Ji L. Tumor-specific activation of human telomerase reverses transcriptase promoter activity by activating enhancer-binding protein-2beta in human lung cancer cells. J Biol Chem. 2007;282:26460-70 pubmed
    The up-regulated expression and telomerase activity of human telomerase reverse transcriptase (hTERT) are hallmarks of tumorigenesis...
  44. Kolquist K, Ellisen L, Counter C, Meyerson M, Tan L, Weinberg R, et al. Expression of TERT in early premalignant lesions and a subset of cells in normal tissues. Nat Genet. 1998;19:182-6 pubmed
    ..of TERC, the RNA component of telomerase, is widespread, the restricted expression pattern of TERT, the telomerase catalytic subunit gene, is correlated with telomerase activity, and its ectopic expression in telomerase-negative cells ..
  45. Jin X, Beck S, Sohn Y, Kim J, Kim S, Yin J, et al. Human telomerase catalytic subunit (hTERT) suppresses p53-mediated anti-apoptotic response via induction of basic fibroblast growth factor. Exp Mol Med. 2010;42:574-82 pubmed
    Although human telomerase catalytic subunit (TERT) has several cellular functions including telomere homeostasis, genomic stability, cell proliferation, and tumorigenesis, the molecular mechanism underlying anti-apoptosis regulated by ..
  46. Pande M, Spitz M, Wu X, Gorlov I, Chen W, Amos C. Novel genetic variants in the chromosome 5p15.33 region associate with lung cancer risk. Carcinogenesis. 2011;32:1493-9 pubmed publisher
    ..A few single-nucleotide polymorphisms (SNPs) in the telomerase reverse transcriptase (TERT) and cleft lip and palate transmembrane 1-like (CLPTM1L) genes located in this region have ..
  47. Wu X, Huang C, He X, Tian Y, Zhou D, He Y, et al. Feedback regulation of telomerase reverse transcriptase: new insight into the evolving field of telomerase in cancer. Cell Signal. 2013;25:2462-8 pubmed publisher
    b>Telomerase reverse transcriptase (TERT) is the catalytic component of telomerase, especially the rate-limiting determinant of telomerase activity...
  48. Wu S, Huang P, Li C, Huang Y, Li X, Wang Y, et al. Telomerase reverse transcriptase gene promoter mutations help discern the origin of urogenital tumors: a genomic and molecular study. Eur Urol. 2014;65:274-7 pubmed publisher
    ..sequencing, 302 patients with various urogenital cancers for somatic mutations in the promoter of the telomerase reverse transcriptase (TERT) gene and determined the clinical relevance of TERT promoter mutations in urogenital cancer...
  49. Lincz L, Mudge L, Scorgie F, Sakoff J, Hamilton C, Seldon M. Quantification of hTERT splice variants in melanoma by SYBR green real-time polymerase chain reaction indicates a negative regulatory role for the beta deletion variant. Neoplasia. 2008;10:1131-7 pubmed
    ..activity is primarily determined by transcriptional regulation of the catalytic subunit, human telomerase reverse transcriptase (hTERT)...
  50. Wang Y, Kowalski J, Tsai H, Marik R, Prasad N, Somervell H, et al. Differentiating alternative splice variant patterns of human telomerase reverse transcriptase in thyroid neoplasms. Thyroid. 2008;18:1055-63 pubmed publisher
    ..The aim of this study was to investigate the gene expression patterns of human telomerase reverse transcriptase (hTERT) alternative splice variants in benign and malignant thyroid tumors in an attempt to find a ..
  51. Liu X, Dakic A, Zhang Y, Dai Y, Chen R, Schlegel R. HPV E6 protein interacts physically and functionally with the cellular telomerase complex. Proc Natl Acad Sci U S A. 2009;106:18780-5 pubmed publisher
  52. Zhang Q, Kim N, Feigon J. Architecture of human telomerase RNA. Proc Natl Acad Sci U S A. 2011;108:20325-32 pubmed publisher
    ..We review this progress to determine the overall architecture of human telomerase RNA. ..
  53. Sexton A, Youmans D, Collins K. Specificity requirements for human telomere protein interaction with telomerase holoenzyme. J Biol Chem. 2012;287:34455-64 pubmed publisher
    ..maintained by the enzyme telomerase, which uses a template within its integral RNA subunit (hTR) and telomerase reverse transcriptase protein (TERT) to accomplish the synthesis of single-stranded DNA repeats...
  54. Landa I, Ganly I, Chan T, Mitsutake N, Matsuse M, Ibrahimpasić T, et al. Frequent somatic TERT promoter mutations in thyroid cancer: higher prevalence in advanced forms of the disease. J Clin Endocrinol Metab. 2013;98:E1562-6 pubmed publisher
    b>TERT encodes the reverse transcriptase component of telomerase, which adds telomere repeats to chromosome ends, thus enabling cell replication. Telomerase activity is required for cell immortalization...
  55. Wang Y, Hu Z, Liang J, Wang Z, Tang J, Wang S, et al. A tandem repeat of human telomerase reverse transcriptase (hTERT) and risk of breast cancer development and metastasis in Chinese women. Carcinogenesis. 2008;29:1197-201 pubmed publisher
    ..A minisatellite tandem repeat, MNS16A, located in the downstream of the human telomerase reverse transcriptase (hTERT) gene was recently identified and reported to have an effect on hTERT expression and ..
  56. Pellatt A, Wolff R, Torres Mejía G, John E, Herrick J, Lundgreen A, et al. Telomere length, telomere-related genes, and breast cancer risk: the breast cancer health disparities study. Genes Chromosomes Cancer. 2013;52:595-609 pubmed publisher
    ..TL-related genes assessed were MEN1, MRE11A, RECQL5, TEP1, TERC, TERF2, TERT, TNKS, and TNKS2. Longer TL was associated with increased breast cancer risk [odds ratio (OR) 1...
  57. Delhommeau F, Thierry A, Feneux D, Lauret E, Leclercq E, Courtier M, et al. Telomere dysfunction and telomerase reactivation in human leukemia cell lines after telomerase inhibition by the expression of a dominant-negative hTERT mutant. Oncogene. 2002;21:8262-71 pubmed
  58. Katzenellenbogen R, Vliet Gregg P, Xu M, Galloway D. NFX1-123 increases hTERT expression and telomerase activity posttranscriptionally in human papillomavirus type 16 E6 keratinocytes. J Virol. 2009;83:6446-56 pubmed publisher
    ..Together, these studies describe the first evidence of posttranscriptional regulation of hTERT, through the direct interaction of the cytoplasmic protein NFX1-123 with hTERT mRNA, in HPV16 E6-expressing keratinocytes. ..
  59. Nishi H, Nakada T, Kyo S, Inoue M, Shay J, Isaka K. Hypoxia-inducible factor 1 mediates upregulation of telomerase (hTERT). Mol Cell Biol. 2004;24:6076-83 pubmed
  60. Li W, Li L, Liu Z, Liu C, Liu Z, Strååt K, et al. Expression of the full-length telomerase reverse transcriptase (hTERT) transcript in both malignant and normal gastric tissues. Cancer Lett. 2008;260:28-36 pubmed
    Activation of telomerase by the induction of a full-length telomerase reverse transcriptase (hTERT) transcript is a critical step during cellular immortalization and malignant transformation...
  61. Allory Y, Beukers W, Sagrera A, Flandez M, Marqués M, Márquez M, et al. Telomerase reverse transcriptase promoter mutations in bladder cancer: high frequency across stages, detection in urine, and lack of association with outcome. Eur Urol. 2014;65:360-6 pubmed publisher
    Hotspot mutations in the promoter of the gene coding for telomerase reverse transcriptase (TERT) have been described and proposed to activate gene expression...
  62. Yang Y, Chen Y, Zhang C, Huang H, Weissman S. Nucleolar localization of hTERT protein is associated with telomerase function. Exp Cell Res. 2002;277:201-9 pubmed
    ..One is a reverse transcriptase subunit, TERT (telomerase reverse transcriptase); another is an RNA template subunit, TR (telomerase RNA)...
  63. Sprague D, Phillips S, Mitchell C, Berger K, Lace M, Turek L, et al. Telomerase activation in cervical keratinocytes containing stably replicating human papillomavirus type 16 episomes. Virology. 2002;301:247-54 pubmed
  64. Tomlinson R, Abreu E, Ziegler T, Ly H, Counter C, Terns R, et al. Telomerase reverse transcriptase is required for the localization of telomerase RNA to cajal bodies and telomeres in human cancer cells. Mol Biol Cell. 2008;19:3793-800 pubmed publisher
    ..The two essential components of human telomerase, telomerase RNA (hTR) and telomerase reverse transcriptase (hTERT), are recruited from distinct subnuclear sites to telomeres during S phase...
  65. Calado R, Regal J, Kajigaya S, Young N. Erosion of telomeric single-stranded overhang in patients with aplastic anaemia carrying telomerase complex mutations. Eur J Clin Invest. 2009;39:1025-32 pubmed publisher
    ..Disrupted telomere structure caused by short telomeric overhangs may contribute to the mechanisms of abnormal haematopoietic compartment senescence and chromosomal instability in human bone marrow failure. ..
  66. Sharma N, Reyes A, Green P, Caron M, Bonini M, Gordon D, et al. Human telomerase acts as a hTR-independent reverse transcriptase in mitochondria. Nucleic Acids Res. 2012;40:712-25 pubmed publisher
    Human telomerase reverse transcriptase (hTERT) is localized to mitochondria, as well as the nucleus, but details about its biology and function in the organelle remain largely unknown...
  67. Zagouri F, Sergentanis T, Gazouli M, Tsigginou A, Dimitrakakis C, Eleutherakis Papaiakovou E, et al. HTERT MNS16A polymorphism in breast cancer: a case-control study. Mol Biol Rep. 2012;39:10859-63 pubmed publisher
    ..Further, larger studies from other countries and subjects seem to be needed as this novel polymorphism is being examined in depth. ..
  68. Goueli B, Janknecht R. Regulation of telomerase reverse transcriptase gene activity by upstream stimulatory factor. Oncogene. 2003;22:8042-7 pubmed
    Upregulation of human telomerase reverse transcriptase (hTERT) transcription accounts for the immortalization of greater than 85% of all human tumor cells. However, the mechanism whereby hTERT expression is activated remains unresolved...
  69. Naka K, Tachibana A, Ikeda K, Motoyama N. Stress-induced premature senescence in hTERT-expressing ataxia telangiectasia fibroblasts. J Biol Chem. 2004;279:2030-7 pubmed
    ..These results suggest that the ATM-dependent signaling pathway triggered by DNA damage is dispensable for activation of p38 MAPK and SIPS in response to IR or oxidative stress. ..
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    ..6 × 10(-7) under a fixed-effects model and P = 1.2 × 10(-3) under a random-effects model). These newly associated variants showed no association with nevus or pigmentation phenotypes in a large British case-control series. ..
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    ..GNL3L/NS forms a complex with the telomerase catalytic subunit [human telomerase reverse transcriptase (hTERT)] and the SWItch-Sucrose NonFermentable (SWI-SNF) complex protein brahma-related gene 1 (BRG1),..
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