TCN1

Summary

Gene Symbol: TCN1
Description: transcobalamin 1
Alias: TC-1, TC1, TCI, transcobalamin-1, haptocorin, haptocorrin, protein R, transcobalamin I (vitamin B12 binding protein, R binder family)
Species: human
Products:     TCN1

Top Publications

  1. McCaddon A, Blennow K, Hudson P, Hughes A, Barber J, Gray R, et al. Transcobalamin polymorphism and serum holo-transcobalamin in relation to Alzheimer's disease. Dement Geriatr Cogn Disord. 2004;17:215-21 pubmed
    ..008) and between 776C homozygotes and heterozygotes (Cox's F test F(46, 108) = 1.7; p = 0.02). Proportionately fewer TC 776C homozygotes appear to develop AD at any given age, but this will require confirmation in a longitudinal study. ..
  2. Hazra A, Kraft P, Lazarus R, Chen C, Chanock S, Jacques P, et al. Genome-wide significant predictors of metabolites in the one-carbon metabolism pathway. Hum Mol Genet. 2009;18:4677-87 pubmed publisher
    ..40 x 10(-15)). Genome-wide significant loci were not identified for plasma folate. These data reveal new biological candidates and confirm prior candidate genes for plasma homocysteine, plasma vitamin B12 and plasma PLP. ..
  3. Lievers K, Afman L, Kluijtmans L, Boers G, Verhoef P, den Heijer M, et al. Polymorphisms in the transcobalamin gene: association with plasma homocysteine in healthy individuals and vascular disease patients. Clin Chem. 2002;48:1383-9 pubmed
    ..Therefore, 259PP individuals, who represent >25% of the general population, may be more susceptible to reduction of plasma tHcy concentrations by increasing the vitamin B(12) status. ..
  4. Zetterberg H, Coppola A, D Angelo A, Palmer M, Rymo L, Blennow K. No association between the MTHFR A1298C and transcobalamin C776G genetic polymorphisms and hyperhomocysteinemia in thrombotic disease. Thromb Res. 2002;108:127-31 pubmed
  5. von Castel Dunwoody K, Kauwell G, Shelnutt K, Vaughn J, Griffin E, Maneval D, et al. Transcobalamin 776C->G polymorphism negatively affects vitamin B-12 metabolism. Am J Clin Nutr. 2005;81:1436-41 pubmed
    ..These data suggest that the TC 776C-->G polymorphism negatively affects the serum holo-TC concentration and provide additional evidence that vitamin B-12 status modulates the homocysteine concentration in this population. ..
  6. Martinelli M, Scapoli L, Palmieri A, Pezzetti F, Baciliero U, Padula E, et al. Study of four genes belonging to the folate pathway: transcobalamin 2 is involved in the onset of non-syndromic cleft lip with or without cleft palate. Hum Mutat. 2006;27:294 pubmed
    ..triad design to test for linkage disequilibrium in the case of seven SNPs mapping on four different genes: transcobalamin 1 and 2 (TCN1 and TCN2), methionine synthase (MTR), and MTR reductase (MTRR)...
  7. Alpers D. Absorption and blood/cellular transport of folate and cobalamin: Pharmacokinetic and physiological considerations. Biochimie. 2016;126:52-6 pubmed publisher
    ..receptor (TC-R), with the asialoglycoprotein receptor (ASGP-R) present in hepatocytes for uptake of haptocorrin-cbl (HC-cbl) complexes...
  8. Zhu X, Wang X, Zhang C, Wang X, Gu Q. A riboswitch sensor to determine vitamin B12 in fermented foods. Food Chem. 2015;175:523-8 pubmed publisher
    ..method has no or less responses to nucleic acid, pseudovitamin B12, vitamin B12 bound to intrinsic factor and haptocorrin. The riboswitch sensor results were similar with HPLC, but they were Ca...
  9. ó Proinsias K, Ociepa M, Pluta K, Chromiński M, Nexo E, Gryko D. Vitamin?B12 Phosphate Conjugation and Its Effect on Binding to the Human B12 -Binding Proteins Intrinsic Factor and Haptocorrin. Chemistry. 2016;22:8282-9 pubmed publisher
    ..The interaction of the alkylated derivatives with haptocorrin was less affected than the interaction with intrinsic factor...

More Information

Publications132 found, 100 shown here

  1. Herrera C, Licon M, Nation C, Jameson S, Wesson D. Genotype diversity of Trypanosoma cruzi in small rodents and Triatoma sanguisuga from a rural area in New Orleans, Louisiana. Parasit Vectors. 2015;8:123 pubmed publisher
    ..The DTUs TcI, TcIV and, for the first time, TcII, were identified in tissues of mice and rats naturally infected with T...
  2. Mutti E, Hunger M, Fedosov S, Nexo E, Krautler B. Organometallic DNA-B12 Conjugates as Potential Oligonucleotide Vectors: Synthesis and Structural and Binding Studies with Human Cobalamin-Transport Proteins. Chembiochem. 2017;18:2280-2291 pubmed publisher
    ..conjugates to three homologous human Cbl transporting proteins, transcobalamin (TC), intrinsic factor (IF), and haptocorrin (HC), are reported...
  3. Caballero Z, Costa Martins A, Ferreira R, P Alves J, Serrano M, Camargo E, et al. Phylogenetic and syntenic data support a single horizontal transference to a Trypanosoma ancestor of a prokaryotic proline racemase implicated in parasite evasion from host defences. Parasit Vectors. 2015;8:222 pubmed publisher
    ..conorhini and T. lewisi, all parasites of mammals. Polymorphisms in TcPRAC genes matched T. cruzi genotypes: TcI-TcIV and Tcbat have unique genes, while the hybrids TcV and TcVI contain TcPRACA and TcPRACB from parental TcII and ..
  4. Gumiel M, da Mota F, Rizzo V, Sarquis O, de Castro D, Lima M, et al. Characterization of the microbiota in the guts of Triatoma brasiliensis and Triatoma pseudomaculata infected by Trypanosoma cruzi in natural conditions using culture independent methods. Parasit Vectors. 2015;8:245 pubmed publisher
    ..Additionally, we identified TcI and TcII types of T. cruzi by sequencing amplicons from the gut metagenomic DNA with primers for the mini-exon gene...
  5. Vieira C, Waniek P, Castro D, Mattos D, Moreira O, Azambuja P. Impact of Trypanosoma cruzi on antimicrobial peptide gene expression and activity in the fat body and midgut of Rhodnius prolixus. Parasit Vectors. 2016;9:119 pubmed publisher
    ..prolixus infected with different T. cruzi strains. The T. cruzi Dm 28c clone (TcI) successfully develops whereas Y strain (TcII) does not complete its life- cycle in R. prolixus...
  6. Barnes P. Inflammatory mechanisms in patients with chronic obstructive pulmonary disease. J Allergy Clin Immunol. 2016;138:16-27 pubmed publisher
    ..is characterized by increased numbers of alveolar macrophages, neutrophils, T lymphocytes (predominantly TC1, TH1, and TH17 cells), and innate lymphoid cells recruited from the circulation...
  7. Campos C, Hartling I, Kaur M, Fernandes A, Santos R, Cerri R. Intramammary infusion of lipopolysaccharide promotes inflammation and alters endometrial gene expression in lactating Holstein cows. J Dairy Sci. 2018;101:10440-10455 pubmed publisher
    ..34-fold increase; IL6 = 3.42-fold increase; and TCN1 = 2.52-fold increase), adhesion molecules (CADM3 = 1.93-fold increase; MMP19 = 1.49-fold increase; EMMPRIN = 1...
  8. Galsgaard K, Winther Sørensen M, Ørskov C, Kissow H, Poulsen S, Vilstrup H, et al. Disruption of glucagon receptor signaling causes hyperaminoacidemia exposing a possible liver - alpha-cell axis. Am J Physiol Endocrinol Metab. 2017;:ajpendo.00198.2017 pubmed publisher
    ..Incubating cultured ?-TC1.9 cells with a mixture of amino acids (Vamin 1%) for 30 minutes and for up to 48 hours led to increased glucagon ..
  9. Alam A, Woo J, Schmitz J, Prinz B, Root K, Chen F, et al. Structural basis of transcobalamin recognition by human CD320 receptor. Nat Commun. 2016;7:12100 pubmed publisher
    ..The observed interaction chemistry can rationalize the high affinity of CD320 for TC and lack of haptocorrin binding...
  10. Zheng W, Zhang B, Shen Z, Yin M, Cao Y, Song H. Biological effects of bone marrow mesenchymal stem cells on hepatitis B virus in vitro. Mol Med Rep. 2017;15:2551-2559 pubmed publisher
    ..BM‑MSCs inhibited the expression of HBV DNA and enhanced the clearance of HBV, which may have been mediated by the regulation of the Tc1/Tc2 cell balance and the mode of cytokine secretion to modulate cytokine expression.
  11. Pei W, Wan X, Shahzad K, Zhang L, Song S, Jin X, et al. Direct modulation of myelin-autoreactive CD4+ and CD8+ T cells in EAE mice by a tolerogenic nanoparticle co-carrying myelin peptide-loaded major histocompatibility complexes, CD47 and multiple regulatory molecules. Int J Nanomedicine. 2018;13:3731-3750 pubmed publisher
    ..of the tNPs markedly decreased the MOG35-55-reactive Th1 and Th17 cells and MOG40-55-reactive Tc1 and Tc17 cells, increased regulatory T cells, inhibited T cell proliferation and elevated T cell apoptosis in ..
  12. Zhao X, Long J, Liang F, Liu N, Sun Y, Xi Y. Vaccination with a Novel Antigen-specific Tolerizing DNA Vaccine Encoding CCOL2A1 Protects Rats from Experimental Rheumatoid Arthritis. Hum Gene Ther. 2018;: pubmed publisher
    ..vaccination with pcDNA-CCOL2A1 markedly decreased serum contens of anti-CII IgG antibodies, induced Th1-to-Th2 and Tc1-to-Tc2 shifts, and decreased the percentages of CD4+CD29+ and Th17 T cells...
  13. Torres Vargas J, Jimenez Coello M, Guzman Marin E, Acosta Viana K, Yadon Z, Gutiérrez Blanco E, et al. Quantitative and histological assessment of maternal-fetal transmission of Trypanosoma cruzi in guinea pigs: An experimental model of congenital Chagas disease. PLoS Negl Trop Dis. 2018;12:e0006222 pubmed publisher
    ..Animals were infected with T. cruzi H4 strain (TcI lineage) before gestation (IBG) or during gestation (IDG)...
  14. Singhania A, Wallington J, Smith C, Horowitz D, Staples K, Howarth P, et al. Multi-tissue Transcriptomics Delineates the Diversity of Airway T Cell Functions in Asthma. Am J Respir Cell Mol Biol. 2017;: pubmed publisher
    ..with predominantly neutrophilic phenotype - several distinct processes were upregulated including neutrophilia (TCN1, MMP9), mucins and oxidative stress responses...
  15. Koo S, Chowdhury I, Szczesny B, Wan X, Garg N. Macrophages Promote Oxidative Metabolism To Drive Nitric Oxide Generation in Response to Trypanosoma cruzi. Infect Immun. 2016;84:3527-3541 pubmed
    ..Mouse (RAW 264.7) and human (THP-1 and primary) m?s were infected for 3 h and 18 h with T. cruzi TcI isolates, SylvioX10/4 (SYL, virulent) and TCC (nonpathogenic), which represent m? stimulation and infection states, ..
  16. Dario M, Rodrigues M, Barros J, Xavier S, D Andrea P, Roque A, et al. Ecological scenario and Trypanosoma cruzi DTU characterization of a fatal acute Chagas disease case transmitted orally (Espírito Santo state, Brazil). Parasit Vectors. 2016;9:477 pubmed publisher
    ..T. vitticeps was the only triatomine species identified and showed T. cruzi infection by DTUs TcI and TcIV. The analysis of cardiac tissue DNA showed mixed infection by T...
  17. Chávez S, Eastman G, Smircich P, Becco L, Oliveira Rizzo C, Fort R, et al. Transcriptome-wide analysis of the Trypanosoma cruzi proliferative cycle identifies the periodically expressed mRNAs and their multiple levels of control. PLoS ONE. 2017;12:e0188441 pubmed publisher
    ..Treating a TcI linage strain with hydroxyurea, we isolated epimastigotes in late G1, S and G2/M cell cycle stages at 70% purity...
  18. Martinez Perez A, Poveda C, Ramírez J, Norman F, Gironés N, Guhl F, et al. Prevalence of Trypanosoma cruzi's Discrete Typing Units in a cohort of Latin American migrants in Spain. Acta Trop. 2016;157:145-50 pubmed publisher
    ..The most common DTU found was TcV (58; 55.2%), followed by TcIV (17; 16.2%), TcII (10; 9.5%) and TcI (4; 3.8%). TcIII and TcVI were not identified from any patient, and 15.2% patients presented mixed infections...
  19. Na G, Yoon S, An J, Yeo R, Song J, Jo M, et al. The relationship between circulating neutrophil gelatinase-associated lipocalin and early alteration of metabolic parameters is associated with dietary saturated fat intake in non-diabetic Korean women. Endocr J. 2017;64:303-314 pubmed publisher
    ..Serum NGAL levels were higher in high-SFA consumers [?7g/day, ?7% of total calorie intake (TCI)] than in low-SFA consumers (<7g/day, <7% of TCI)...
  20. Curzytek K, Kubera M, Majewska Szczepanik M, Szczepanik M, Marcińska K, Ptak W, et al. Inhibition of 2,4-dinitrofluorobenzene-induced contact hypersensitivity reaction by antidepressant drugs. Pharmacol Rep. 2013;65:1237-46 pubmed
    ..The antidepressants significantly suppressed the CHS reaction mediated by Tc1 cells: desipramine by 55% and fluoxetine by 54% compared to the positive control...
  21. Majewska Szczepanik M, Yamamoto N, Askenase P, Szczepanik M. Epicutaneous immunization with phosphorylcholine conjugated to bovine serum albumin (PC-BSA) and TLR9 ligand CpG alleviates pneumococcal pneumonia in mice. Pharmacol Rep. 2014;66:570-5 pubmed publisher
    ..We have previously shown that EC immunization with various protein antigens inhibits both Th1- and Tc1-mediated contact hypersensitivity (CHS) in mice...
  22. Zaninotto L, Solmi M, Toffanin T, Veronese N, Cloninger C, Correll C. A meta-analysis of temperament and character dimensions in patients with mood disorders: Comparison to healthy controls and unaffected siblings. J Affect Disord. 2016;194:84-97 pubmed publisher
    ..results from the Tridimensional Personality Questionnaire (TPQ) or the Temperament and Character Inventory (TCI). Subgroup, sensitivity and meta-regression analyses were also conducted...
  23. Fraga J, Fernández Calienes A, Montalvo A, Maes I, Deborggraeve S, Büscher P, et al. Phylogenetic analysis of the Trypanosoma genus based on the heat-shock protein 70 gene. Infect Genet Evol. 2016;43:165-72 pubmed publisher
    ..cruzi clade, three groups of T. cruzi discrete typing units could be clearly distinguished, corresponding to TcI, TcIII, and TcII+V+VI, while support for TcIV was lacking...
  24. Song J, Gao Y, Zhou W, Yang C, Xu Y, Ping B, et al. [Immunomodulatory effects of human amniotic versus bone marrow-derived mesenchymal stem cells on peripheral blood T lymphocytes in vitro]. Nan Fang Yi Ke Da Xue Xue Bao. 2017;37:780-785 pubmed
    ..with either hAMSCs or hBMSCs significantly increased the proportions of Treg, Th2 and Tc2 and decreased Th1 and Tc1 cell subsets in the PBMCs as compared with the PBMCs cultured alone (P<0...
  25. Liu Y, Li Y, Gong Y, Yu N, Zhang Y, You R, et al. CD26 expression is down-regulated on CD8+ T cells in patients with Hashimoto's thyroiditis. Int Immunopharmacol. 2018;54:280-285 pubmed publisher
    ..07). The percentages of CD8+ T cells and Tc1 cells with CD26 expression were decreased in HT patients compared with those in healthy controls, and the mean ..
  26. Yamano E, Ishii A, Tanaka M, Nomura S, Watanabe Y. Neural basis of individual differences in the response to mental stress: a magnetoencephalography study. Brain Imaging Behav. 2016;10:1160-1171 pubmed
    ..Twenty healthy male volunteers completed the Temperament and Character Inventory (TCI). The experiment included two types of tasks: a non-stress-inducing task and a stress-inducing task...
  27. Gogoll K, Stein P, Lee K, Arnold P, Peters T, Schild H, et al. Solid nanoemulsion as antigen and immunopotentiator carrier for transcutaneous immunization. Cell Immunol. 2016;308:35-43 pubmed publisher
    ..Within this work, the immunostimulatory effect of imiquimod is further exploited in a transcutaneous immunization (TCI) approach based on a solid nanoemulsion (SN) formulation...
  28. Kuang L, Deng T, Wang Q, QIU S, Liang Y, He Z, et al. Dendritic cells induce Tc1 cell differentiation via the CD40/CD40L pathway in mice after exposure to cigarette smoke. Am J Physiol Lung Cell Mol Physiol. 2016;311:L581-9 pubmed publisher
    ..We investigated the role of the CD40/CD40L pathway in Tc1 cell differentiation induced by dendritic cells in a mouse model of emphysema, and in vitro...
  29. Neva J, Lakhani B, Brown K, Wadden K, Mang C, Ledwell N, et al. Multiple measures of corticospinal excitability are associated with clinical features of multiple sclerosis. Behav Brain Res. 2016;297:187-95 pubmed publisher
    ..short-interval intracortical inhibition (SICI), intracortical facilitation (ICF) and transcallosal inhibition (TCI) in 26 individuals with MS and 11 healthy controls...
  30. Panebianco F, Mazzanti C, Tomei S, Aretini P, Franceschi S, Lessi F, et al. The combination of four molecular markers improves thyroid cancer cytologic diagnosis and patient management. BMC Cancer. 2015;15:918 pubmed publisher
    ..of the BRAF V600E mutation (exon15) by pyrosequencing and further assessed for mRNA expression of four genes (KIT, TC1, miR-222, miR-146b) by quantitative polymerase chain reaction...
  31. Rojas Cortez M, Pinazo M, Garcia L, Arteaga M, Uriona L, Gamboa S, et al. Trypanosoma cruzi-infected Panstrongylus geniculatus and Rhodnius robustus adults invade households in the Tropics of Cochabamba region of Bolivia. Parasit Vectors. 2016;9:158 pubmed publisher
  32. Wang Y, Pryputniewicz Dobrinska D, Nagy E, Kaufman C, Singh M, Yant S, et al. Regulated complex assembly safeguards the fidelity of Sleeping Beauty transposition. Nucleic Acids Res. 2017;45:311-326 pubmed publisher
    The functional relevance of the inverted repeat structure (IR/DR) in a subgroup of the Tc1/mariner superfamily of transposons has been enigmatic...
  33. Zhu P, Bailey S, Lei B, Paulos C, Atkinson C, Tomlinson S. Targeted Complement Inhibition Protects Vascularized Composite Allografts From Acute Graft Injury and Prolongs Graft Survival When Combined With Subtherapeutic Cyclosporine A Therapy. Transplantation. 2017;101:e75-e85 pubmed publisher
    ..2 days. Protection was associated with significantly reduced T cell infiltration of allografts and Tc1 cells in recipient spleens...
  34. Nielsen R, Sørensen B, Birn H, Christensen E, Nexø E. Transcellular transport of vitamin B(12) in LLC-PK1 renal proximal tubule cells. J Am Soc Nephrol. 2001;12:1099-106 pubmed
    ..The release is polarized in such a way that vitamin in the apical medium is bound to proteins with the size of haptocorrin, whereas the B(12) released at the basolateral side is complexed to two different proteins with the sizes of ..
  35. Roychowdhury S, Shenoy U, Waghmare U, Biswas K. Tailoring of Electronic Structure and Thermoelectric Properties of a Topological Crystalline Insulator by Chemical Doping. Angew Chem Int Ed Engl. 2015;54:15241-5 pubmed publisher
    ..Owing to its vanishingly small bulk band gap, a TCI like Pb0.6 Sn0.4 Te has poor thermoelectric properties. Breaking of crystal symmetry can widen the band gap of TCI...
  36. Seo S, Ryu J, Kang S, Lee J, Kim H, Jang M, et al. Safety of Target-Controlled Propofol Infusion by Gastroenterologists in Patients Undergoing Endoscopic Resection. Dig Dis Sci. 2016;61:3199-3206 pubmed
    A target-controlled infusion (TCI) of a propofol system uses a pharmacokinetic model to achieve and maintain a selected target blood propofol concentration...
  37. Almendros I, Khalyfa A, Trzepizur W, Gileles Hillel A, Huang L, Akbarpour M, et al. Tumor Cell Malignant Properties Are Enhanced by Circulating Exosomes in Sleep Apnea. Chest. 2016;150:1030-1041 pubmed publisher
    ..C57/B6 male mice were randomized to 6 weeks of IH or room air (RA). A subgroup was injected with TC1 lung carcinoma cells in the left flank after 2 weeks of IH...
  38. Li J, Yan Y, Meng Z, Liu S, Beck P, Ghosh S, et al. Microscopic Colitis Evolved Into Inflammatory Bowel Diseases Is Characterized by Increased Th1/Tc1 Cells in Colonic Mucosal Lamina Propria. Dig Dis Sci. 2017;62:2755-2767 pubmed publisher
    ..detect major T cell subsets characterized by key cytokines and master transcription factors (IFN? and T-bet for Th1/Tc1, GATA-3 for Th2/Tc2, IL-17 and RORc for Th17/Tc17, FoxP3 for Treg/Tcreg) as well as TNF?+ cells (partly ..
  39. Tsiraki M, Savvaidis I. The effects of citrus extract (Citrox©) on the naturally occurring microflora and inoculated pathogens, Bacillus cereus and Salmonella enterica, in a model food system and the traditional Greek yogurt-based salad Tzatziki. Food Microbiol. 2016;53:150-5 pubmed publisher
    The antimicrobial effect of citrus extract (at 1 mL/kg [TC1] and 2 mL/kg [TC2]) on the naturally occurring microflora and inoculated pathogens (Bacillus cereus and Salmonella enterica, at ca...
  40. El Menyar A, Latifi R, Abdulrahman H, Zarour A, Tuma M, Parchani A, et al. Age and traumatic chest injury: a 3-year observational study. Eur J Trauma Emerg Surg. 2013;39:397-403 pubmed publisher
    A quarter of trauma-related deaths are attributable to traumatic chest injury (TCI). To outline the pattern and outcome of TCI in a rapidly developing country among different age groups...
  41. Chen J, Lv X, Zhang L, Chen Z. [Effects of remifentanil and dexmedetomidine on recovery profiles after oral and maxillofacial surgery]. Shanghai Kou Qiang Yi Xue. 2016;25:101-4 pubmed
    ..Dexmedetomidine can provide longer sedation time than TCI of remifentanil.
  42. Aluja A, García L, García Ã, Blanco E. Testosterone and disinhibited personality in healthy males. Physiol Behav. 2016;164:227-32 pubmed publisher
    ..Personality was assessed by the novelty seeking scale of Cloninger's Temperament-Character Inventory (TCI), and a reduced version of the Zuckerman-Kuhlman Personality Questionnaire (ZKPQ)...
  43. Kim M, Lee E, Shin H, Jung H, Kim T, Kim T, et al. The effect of PPAR? agonist on SGLT2 and glucagon expressions in alpha cells under hyperglycemia. J Endocrinol Invest. 2017;40:1069-1076 pubmed publisher
    ..An Alpha TC1-6 cell line was cultured in control (5 mM) or hyperglycemia (HG, 15 mM) for 72 h...
  44. Hodo C, Wilkerson G, Birkner E, Gray S, Hamer S. Trypanosoma cruzi Transmission Among Captive Nonhuman Primates, Wildlife, and Vectors. Ecohealth. 2018;15:426-436 pubmed publisher
    ..cruzi DNA, with two DTUs in equal proportions, TcI and TcIV. In contrast, consistently high concentrations of T...
  45. Pennone J, Mezencio B, Amadio A, Serrão J. Dynamic Parameters Variability: Time Interval Interference on Ground Reaction Force During Running. Percept Mot Skills. 2016;122:533-41 pubmed publisher
    ..48%, respectively. There was no significant difference for the ground reaction forces parameters Fy1, tFy1, TC1, Imp50, Fy2, and tFy2 between intervals and sessions...
  46. Oliveira M, Branquinho R, Alessio G, Mello C, Nogueira de Paiva N, Carneiro C, et al. TcI, TcII and TcVI Trypanosoma cruzi samples from Chagas disease patients with distinct clinical forms and critical analysis of in vitro and in vivo behavior, response to treatment and infection evolution in murine model. Acta Trop. 2017;167:108-120 pubmed publisher
    ..This study intended to characterize a range of biological properties of TcI, TcII and TcVI T. cruzi samples in order to verify the existence of these associations...
  47. Tomasini N, Diosque P. Phylogenomics of Trypanosoma cruzi: Few evidence of TcI/TcII mosaicism in TcIII challenges the hypothesis of an ancient TcI/TcII hybridization. Infect Genet Evol. 2017;50:25-27 pubmed publisher
    ..Some authors proposed that these lineages have been the result of an ancient hybridization between TcI and TcII, and this was one of the most accepted evolutionary models in the scientific community for several years...
  48. Kang H, Mohamed H, Takashina M, Mori T, Fujino Y, Hagihira S. Individual indicators of appropriate hypnotic level during propofol anesthesia: highest alpha power and effect-site concentrations of propofol at loss of response. J Anesth. 2017;31:502-509 pubmed publisher
    ..Propofol was infused using a TCI pump. Target concentration was adjusted so that Ce of propofol was gradually increased...
  49. Gao Y, Wu J, Zhang M, Hou M, Ji M. Mice lack of LRG-47 display the attenuated outcome of infection with Schistosoma japonicum. Parasitol Res. 2016;115:1185-93 pubmed publisher
    ..significantly decreased egg burden, low schistosome-specific antibody response, and the decreased Th1 and increased Tc1 responses...
  50. Wang X, Wang T, Tian Z, Brogan D, Li J, Ma Y. Asleep-awake-asleep regimen for epilepsy surgery: a prospective study of target-controlled infusion versus manually controlled infusion technique. J Clin Anesth. 2016;32:92-100 pubmed publisher
    ..of intravenous anesthesia for AAA craniotomies are widely used: infusion by means of target-controlled infusion (TCI) and traditional manually-controlled infusion (MCI)...
  51. Evangelinos M, Anagnostopoulos G, Karvela Kalogeraki I, Stathopoulou P, Scazzocchio C, Diallinas G. Minos as a novel Tc1/mariner-type transposable element for functional genomic analysis in Aspergillus nidulans. Fungal Genet Biol. 2015;81:1-11 pubmed publisher
    ..The Minos element from Drosophila hydei, a Tc1/mariner-like transposon, has proved as a very efficient tool for heterologous transposition in several metazoa...
  52. Jansen A, Xavier S, Roque A. The multiple and complex and changeable scenarios of the Trypanosoma cruzi transmission cycle in the sylvatic environment. Acta Trop. 2015;151:1-15 pubmed publisher
    ..Didelphis spp. are able to maintain high and long-lasting parasitemias (positive hemocultures) caused by TcI but maintain and rapidly control parasitemias caused by TcII to almost undetectable levels...
  53. Samson M, Ly K, Tournier B, Janikashvili N, Trad M, Ciudad M, et al. Involvement and prognosis value of CD8(+) T cells in giant cell arteritis. J Autoimmun. 2016;72:73-83 pubmed publisher
    ..T cells and levels of soluble granzymes A and B were higher in patients than in controls, whereas the percentage of Tc1 cells (CD3(+)CD8(+)IFN-?(+)) was similar...
  54. Baillie T. Targeted Covalent Inhibitors for Drug Design. Angew Chem Int Ed Engl. 2016;55:13408-13421 pubmed publisher
    ..on the reversible, noncovalent interaction of a ligand with its biological target, a targeted covalent inhibitor (TCI) is designed such that the initial, reversible association is followed by the formation of a covalent bond between ..
  55. Park H, Suh B, Lee H, Lee K. Temperament and characteristics related to attention deficit/hyperactivity disorder symptoms. Compr Psychiatry. 2016;70:112-7 pubmed publisher
    ..students completed the 140 5-point Likert items on the Temperament and Character Inventory-Revised Short version (TCI-RS) and the Attention Deficit/Hyperactivity Disorder Self-Rated Scale (ASRS)...
  56. Li X, Xu C, Luo Y, Zhang S, Huang C, Zou K, et al. Influence of the flow field on ?-cyclodextrin glycosyltransferase production by Escherichia coli BL21. Bioprocess Biosyst Eng. 2018;41:819-829 pubmed publisher
    ..were three layers stirring blades and C1 as a control, were selected to carry out batch fermentation experiments (TC1, TC6, TC7, and TC8) for validation...
  57. Reis Cunha J, Rodrigues Luiz G, Valdivia H, Baptista R, Mendes T, de Morais G, et al. Chromosomal copy number variation reveals differential levels of genomic plasticity in distinct Trypanosoma cruzi strains. BMC Genomics. 2015;16:499 pubmed publisher
    ..cruzi, the etiologic agent of Chagas disease, is currently divided into six discrete typing units (DTUs), named TcI-TcVI. CL Brener, the reference strain of the T...
  58. Chang Y, Tsai T, Hsu H, Chen Y, Chi K, Peng S. Sedation for gastrointestinal endoscopy with the application of target-controlled infusion. Turk J Gastroenterol. 2015;26:417-22 pubmed publisher
    ..The goal of our study was to establish the quality and plausibility of target-controlled infusion (TCI) as a sedation mechanism for upper and lower gastrointestinal (GI) endoscopies...
  59. Yang Y, Hu L, Chen H, Li B, Fan X, Li J, et al. Target-controlled infusion of remifentanil with or without flurbiprofen axetil in sedation for extracorporeal shock wave lithotripsy of pancreatic stones: a prospective, open-label, randomized controlled trial. BMC Anesthesiol. 2015;15:161 pubmed publisher
    ..One group of patients received target controlled infusion (TCI) of remifentanil, while the other group of patients received TCI of remifentanil plus a bolus of flurbiprofen ..
  60. Salehi B, Zarinfar N, Noori H. The relationship between personality traits and AIDS in patients with human immunodeficiency virus. Asian J Psychiatr. 2016;21:41-5 pubmed publisher
    ..Demographic information checklist and Cloninger' Temperament and Character inventory (TCI) were two instruments applied in the study. SPSS software V...
  61. Erić A, Erić I, Curković M, Dodig Curkovic K, Kralik K, Kovač V, et al. The temperament and character traits in patients with major depressive disorder and bipolar affective disorder with and without suicide attempt. Psychiatr Danub. 2017;29:171-178 pubmed
    ..were also assessed according to ICD-10 and a self-report questionnaire, the Temperament and Character Inventory (TCI) was applied...
  62. Crandall W, Davis J, Dotson J, Elmaraghy C, Fetzer M, Hayes D, et al. Clinical Indices Can Standardize and Monitor Pediatric Care: A Novel Mechanism to Improve Quality and Safety. J Pediatr. 2018;193:190-195.e1 pubmed publisher
    ..Index; CKDCI), Pulmonology (Lung Transplantation Care Index; LTCI), and Otolaryngology (Tracheostomy Care Index; TCI)...
  63. Nousiainen A, Björklöf K, Sagarkar S, Nielsen J, Kapley A, Jørgensen K. Bioremediation strategies for removal of residual atrazine in the boreal groundwater zone. Appl Microbiol Biotechnol. 2015;99:10249-59 pubmed publisher
    ..using citrate or molasses and augmentation with Pseudomonas citronellolis ADP or Arthrobacter aurescens strain TC1, up to 76% of atrazine was mineralized at 30 °C, and the atrazine degradation gene numbers increased up to 10(7) ..
  64. Kaurav M, Minz S, Sahu K, Kumar M, Madan J, Pandey R. Nanoparticulate mediated transcutaneous immunization: Myth or reality. Nanomedicine. 2016;12:1063-1081 pubmed publisher
    Transcutaneous immunization (TCI) is a promising route of vaccine delivery through skin due to many well documented advantages. The main obstacle in TCI is the skin's top dead layer i.e. stratum corneum which is difficult to penetrate...
  65. Yıldızer Keriş E, Atabek D, Gungor K. Effects of fixed and removable space maintainers on halitosis. BMC Oral Health. 2016;16:99 pubmed
    ..The the plaque index (PI), gingival index (GI), periodontal screening index (PSI), tongue coating index (TCI) records and the halitosis measurements were obtained at three time periods (T1: immediately after application, T2: ..
  66. Carranza N, Bonta H, Gualtieri A, Rojas M, Galli F, Caride F. Alveolar dimensional changes relevant to implant placement after minimally traumatic tooth extraction with primary closure. Acta Odontol Latinoam. 2016;29:105-114 pubmed
    ..After a minimally traumatic extraction, two CT scans were performed; the first within 24 hours postextraction (TC1) and the second 6 months (TC2) later...
  67. Anovazzi G, Medeiros M, Pigossi S, Finoti L, Mayer M, Rossa C, et al. Functional Haplotypes in Interleukin 4 Gene Associated with Periodontitis. PLoS ONE. 2017;12:e0169870 pubmed publisher
    ..Individuals carrying the TCI/CCI genotype (S-haplotype) of the IL-4 gene are 5 times more susceptible to CP, whereas the CTI/TTD genotype (P-..
  68. Cecere M, Leporace M, Fernández M, Zárate J, Moreno C, Gürtler R, et al. Host-Feeding Sources and Infection With Trypanosoma cruzi of Triatoma infestans and Triatoma eratyrusiformis (Hemiptera: Reduviidae) From the Calchaqui Valleys in Northwestern Argentina. J Med Entomol. 2016;53:666-673 pubmed
    ..6%), which thrived in the dry-shrub fences. The main T. cruzi DTU identified in both vectors was T. cruzi I (TcI)...
  69. Khedr E, Elbeh K, Elserogy Y, Khalifa H, Ahmed M, Hafez M, et al. Motor cortical excitability in obsessive-compulsive disorder: Transcranial magnetic stimulation study. Neurophysiol Clin. 2016;46:135-43 pubmed publisher
    ..RMT and AMT), motor evoked potential (MEP) amplitude, cortical silent period (CSP) and transcallosal inhibition (TCI) durations, short-interval intracortical inhibition (SICI), and intracortical facilitation...
  70. de Souza Godoi P, Piechnik C, de Oliveira A, Sfeir M, de Souza E, Rogez H, et al. qPCR for the detection of foodborne Trypanosoma cruzi. Parasitol Int. 2017;66:563-566 pubmed publisher
    ..0μL and positives and negatives controls were included in every run. As positive control DNA from two genotypes TcI and TcII were used. As negative control the reaction product without DNA of the parasite was used...
  71. Bolat N, Kadak T, Eliaçik K, Sargin E, Incekas S, Gunes H. Maternal and paternal personality profiles of adolescent suicide attempters. Psychiatry Res. 2017;248:77-82 pubmed publisher
    ..Given its neurobiological background, Cloninger's model of personality, the Temperament and Character Inventory (TCI), may help to identify the maternal and paternal personality dimensions associated with adolescent suicide attempts...
  72. Novotny L, Clements J, Goodman S, Bakaletz L. Transcutaneous Immunization with a Band-Aid Prevents Experimental Otitis Media in a Polymicrobial Model. Clin Vaccine Immunol. 2017;24: pubmed publisher
    ..clinically relevant viral-bacterial coinfection model of NTHI-induced OM, we performed transcutaneous immunization (TCI) via a band-aid delivery system to administer each of three promising NTHI vaccine candidates derived from ..
  73. Mahajan V, Samra T, Puri G. Anaesthetic depth control using closed loop anaesthesia delivery system vs. target controlled infusion in patients with moderate to severe left ventricular systolic dysfunction. J Clin Anesth. 2017;42:106-113 pubmed publisher
    ..of anaesthetic depth control using Closed Loop Anaesthesia Delivery System (CLADS) and Target Controlled Infusion (TCI) in patients with moderate to severe left ventricular dysfunction (LVSD). Randomized control trial...
  74. Liu S, Liu Y, Lv Y, Yao J, Yue D, Zhang M, et al. IL-18 Contributes to Bone Cancer Pain by Regulating Glia Cells and Neuron Interaction. J Pain. 2017;: pubmed publisher
    ..IL-18, released from glial cells, has been reported to be involved in neuropathic pain. Here, we investigated the role of IL-18 in bone cancer pain...
  75. Padilla C, Alvarado U, Ventura G, Luna Caipo D, Suárez M, Tuñoque J, et al. Identifying Trypanosoma cruzi discreet typing units in triatomines collected in different natural regions of Perú. Biomedica. 2017;37:167-179 pubmed publisher
    Trypanosoma cruzi has been divided by international consensus into six discrete typing units (DTU): TcI, TcII, TcIII, TcIV, TcV y TcVI. The factors determining the dynamics of T...
  76. Dario M, Lisboa C, Costa L, Moratelli R, Nascimento M, Costa L, et al. High Trypanosoma spp. diversity is maintained by bats and triatomines in Espírito Santo state, Brazil. PLoS ONE. 2017;12:e0188412 pubmed publisher
    ..and Callithrix geoffroyi, which was infected by T. minasense. Bats presented T. c. cruzi TcI and TcIII/V, T. c. marinkellei, T. dionisii, T. rangeli B and D, and Trypanosoma sp. infections...
  77. Anello G, Guéant Rodriguez R, Bosco P, Gueant J, Romano A, Namour B, et al. Homocysteine and methylenetetrahydrofolate reductase polymorphism in Alzheimer's disease. Neuroreport. 2004;15:859-61 pubmed
    ..of the methylenetetrahydrofolate reductase (MTHFR 677 C-->T and 1298 A-->C) and transcobalamin genes (TCN1 776 C-->G )...
  78. Cao T, Yang D, Zhang X, Wang Y, Qiao Z, Gao L, et al. FAM3D inhibits glucagon secretion via MKP1-dependent suppression of ERK1/2 signaling. Cell Biol Toxicol. 2017;33:457-466 pubmed publisher
    ..In the present study, we investigated whether FAM3D modulates glucagon production in mouse pancreatic alpha TC1 clone 6 (?TC1-6) cells...
  79. Fleming M, Rothwell J, Sztriha L, Teo J, Newham D. The effect of transcranial direct current stimulation on motor sequence learning and upper limb function after stroke. Clin Neurophysiol. 2017;128:1389-1398 pubmed publisher
    ..arrangement on the efficacy of tDCS in stroke survivors and determine whether changes in transcallosal inhibition (TCI) underlie improvements. 24 stroke survivors (3-124months post-stroke) with upper limb impairment participated...
  80. Araujo P, Terra R, Santos T, Chate R, Paiva A, Pego Fernandes P. Ultrasound-guided intrapleural positioning of pleural catheters: influence on immediate lung expansion and pleurodesis in patients with recurrent malignant pleural effusion. J Bras Pneumol. 2017;43:190-194 pubmed publisher
    ..A TC de tórax foi realizada duas vezes: imediatamente antes da pleurodese (TCi) e 30 dias após a pleurodese (TC30)...
  81. Atherton M, Stephenson K, Pol J, Wang F, Lefebvre C, Stojdl D, et al. Customized Viral Immunotherapy for HPV-Associated Cancer. Cancer Immunol Res. 2017;5:847-859 pubmed publisher
    ..MG1-E6E7 vaccination in the HPV+ murine model TC1 clears large tumors in a CD8+-dependent manner and results in durable immunologic memory...
  82. Zheng Y, Zhang L, Wang Y, Chen S, Lei L, Tang N, et al. Thyroid cancer 1 (C8orf4) shows high expression, no mutation and reduced methylation level in lung cancers, and its expression correlates with ?-catenin and DNMT1 expression and poor prognosis. Oncotarget. 2017;8:62880-62890 pubmed publisher
    Thyroid cancer 1 (TC1, C8orf4) plays important roles in tumors...
  83. Piskunov A, Fusté A, Teryaeva N, Moshkin A, Ruiz J. The hypothalamic-pituitary-thyroid axis and personality in a sample of healthy subjects. Psychoneuroendocrinology. 2018;87:181-187 pubmed publisher
    ..Personality traits were assessed using the revised short versions of the Temperament and Character Inventory (TCI-140) and the NEO Five-Factor Inventory (NEO-FFI)...
  84. Nouri Shirazi M, Tamjidi S, Nourishirazi E, Guinet E. TLR8 combined withTLR3 or TLR4 agonists enhances DC-NK driven effector Tc1 cells. Immunol Lett. 2018;193:58-66 pubmed publisher
    ..new vaccines formulation is moving toward a careful selection of adjuvants that also elicit significant Th1 or Tc1 responses...
  85. Cao T, Zhang X, Yang D, Wang Y, Qiao Z, Huang J, et al. Antioxidant effects of epigallocatechin-3-gallate on the aTC1-6 pancreatic alpha cell line. Biochem Biophys Res Commun. 2018;495:693-699 pubmed publisher
    ..study, we investigated whether epigallocatechin-3-gallate (EGCG) has antioxidant potential on pancreatic alpha TC1-6 (?TC1-6) cell lines and protect the normal function of ?-cells from H2O2 induced oxidative ..
  86. Nagano H, Kawabata M, Sugita G, Tsuruhara A, Ohori J, Jimura T, et al. Transcutaneous immunization with pneumococcal surface protein A in mice. Laryngoscope. 2017;: pubmed publisher
    ..The goal of the study was to investigate the effectiveness of transcutaneous immunization (TCI) for induction of pneumococcal surface protein A (PspA) responses in the upper respiratory tract.
  87. Johnston J, Yang Feng T, Berliner N. Genomic structure and mapping of the chromosomal gene for transcobalamin I (TCN1): comparison to human intrinsic factor. Genomics. 1992;12:459-64 pubmed
    ..The expression of the gene for TCI (TCN1) within neutrophils has been shown to be restricted to the later stages of myeloid development and can therefore be ..
  88. Johnston J, Bollekens J, Allen R, Berliner N. Structure of the cDNA encoding transcobalamin I, a neutrophil granule protein. J Biol Chem. 1989;264:15754-7 pubmed
    Transcobalamin I (TCI) is a member of the R binder family of vitamin B12 binding proteins. It is a major protein constituent of secondary granules in neutrophils...
  89. Guéant Rodriguez R, Juilliere Y, Candito M, Adjalla C, Gibelin P, Herbeth B, et al. Association of MTRRA66G polymorphism (but not of MTHFR C677T and A1298C, MTRA2756G, TCN C776G) with homocysteine and coronary artery disease in the French population. Thromb Haemost. 2005;94:510-5 pubmed
    ..5 (95% CI: 1.5-13.1, P = 0.0051). In conclusion, in contrast to North Europe studies, MTRRAA genotype is a genetic determinant of moderate hyperhomocysteinemia associated with CAD in a French population without vitamin fortification. ..
  90. Fedosov S, Fedosova N, Krautler B, Nexø E, Petersen T. Mechanisms of discrimination between cobalamins and their natural analogues during their binding to the specific B12-transporting proteins. Biochemistry. 2007;46:6446-58 pubmed
    Three proteins, intrinsic factor (IF), transcobalamin (TC), and haptocorrin (HC), all have an extremely high affinity for the cobalamins (Cbls, Kd approximately 5 fM) but discriminate these physiological ligands from Cbl analogues with ..
  91. Siegfried E, Jaworski J, KAISER J, Hebert A. Systematic review of published trials: long-term safety of topical corticosteroids and topical calcineurin inhibitors in pediatric patients with atopic dermatitis. BMC Pediatr. 2016;16:75 pubmed publisher
    ..a controversial Boxed Warning based on a theoretical risk of malignancy (eg, skin and lymphoma) that has limited TCI use for standard-of-care maintenance therapy...
  92. Mazzucco S, Li L, Tuna M, Pendlebury S, Wharton R, Rothwell P. Hemodynamic correlates of transient cognitive impairment after transient ischemic attack and minor stroke: A transcranial Doppler study. Int J Stroke. 2016;11:978-986 pubmed
    Transient cognitive impairment (TCI) on the Mini Mental State Evaluation score is common after transient ischemic attack/minor stroke and might identify patients at increased risk of dementia...