SLC2A2

Summary

Gene Symbol: SLC2A2
Description: solute carrier family 2 member 2
Alias: GLUT2, solute carrier family 2, facilitated glucose transporter member 2, glucose transporter type 2, liver, solute carrier family 2 (facilitated glucose transporter), member 2
Species: human
Products:     SLC2A2

Top Publications

  1. Tanizawa Y, Riggs A, Chiu K, Janssen R, Bell D, Go R, et al. Variability of the pancreatic islet beta cell/liver (GLUT 2) glucose transporter gene in NIDDM patients. Diabetologia. 1994;37:420-7 pubmed
    ..The allelic frequency of the ATT (Ile110) in NIDDM patients (39.6%, n = 48) and that in controls (47.1%, n = 52) did not differ (p = 0.32, Fisher's exact test).(ABSTRACT TRUNCATED AT 250 WORDS) ..
  2. Dupuis J, Langenberg C, Prokopenko I, Saxena R, Soranzo N, Jackson A, et al. New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk. Nat Genet. 2010;42:105-16 pubmed publisher
    ..These include nine loci newly associated with fasting glucose (in or near ADCY5, MADD, ADRA2A, CRY2, FADS1, GLIS3, SLC2A2, PROX1 and C2CD4B) and one influencing fasting insulin and HOMA-IR (near IGF1)...
  3. Møller A, Jensen N, Pildal J, Drivsholm T, Borch Johnsen K, Urhammer S, et al. Studies of genetic variability of the glucose transporter 2 promoter in patients with type 2 diabetes mellitus. J Clin Endocrinol Metab. 2001;86:2181-6 pubmed
    ..This study was performed to test the hypothesis that genetic variation in the promoter of the glucose transporter 2 (GLUT2) might predispose to prediabetic phenotypes or type 2 diabetes...
  4. Dawson P, Mychaleckyj J, Fossey S, Mihic S, Craddock A, Bowden D. Sequence and functional analysis of GLUT10: a glucose transporter in the Type 2 diabetes-linked region of chromosome 20q12-13.1. Mol Genet Metab. 2001;74:186-99 pubmed
    ..3 mM. D-Glucose and D-galactose competed with 2-deoxy-D-glucose and transport was inhibited by phloretin. The gene localization and functional properties suggest a role for GLUT10 in glucose metabolism and Type 2 diabetes. ..
  5. Laukkanen O, Lindström J, Eriksson J, Valle T, Hämäläinen H, Ilanne Parikka P, et al. Polymorphisms in the SLC2A2 (GLUT2) gene are associated with the conversion from impaired glucose tolerance to type 2 diabetes: the Finnish Diabetes Prevention Study. Diabetes. 2005;54:2256-60 pubmed
    ..study was to investigate whether single nucleotide polymorphisms (SNPs) in the genes regulating insulin secretion (SLC2A2 [encoding GLUT2], GCK, TCF1 [encoding HNF-1alpha], HNF4A, GIP, and GLP1R) are associated with the conversion from ..
  6. Manzano S, Williamson G. Polyphenols and phenolic acids from strawberry and apple decrease glucose uptake and transport by human intestinal Caco-2 cells. Mol Nutr Food Res. 2010;54:1773-80 pubmed publisher
    ..Using sodium-containing (glucose transporters SGLT1 and GLUT2 both active) and sodium-free (only GLUT2 active) conditions, we show that the inhibition of GLUT2 was greater than ..
  7. Ait Omar A, Monteiro Sepulveda M, Poitou C, Le Gall M, Cotillard A, Gilet J, et al. GLUT2 accumulation in enterocyte apical and intracellular membranes: a study in morbidly obese human subjects and ob/ob and high fat-fed mice. Diabetes. 2011;60:2598-607 pubmed publisher
    In healthy rodents, intestinal sugar absorption in response to sugar-rich meals and insulin is regulated by GLUT2 in enterocyte plasma membranes. Loss of insulin action maintains apical GLUT2 location...
  8. Santer R, Schneppenheim R, Dombrowski A, Gotze H, Steinmann B, Schaub J. Mutations in GLUT2, the gene for the liver-type glucose transporter, in patients with Fanconi-Bickel syndrome. Nat Genet. 1997;17:324-6 pubmed
    ..Here we report mutations in the gene encoding the facilitative glucose transporter 2 (GLUT2) in three FBS families, including the original patient described in 1949 by Fanconi and Bickel...
  9. Barroso I, Luan J, Middelberg R, Harding A, Franks P, Jakes R, et al. Candidate gene association study in type 2 diabetes indicates a role for genes involved in beta-cell function as well as insulin action. PLoS Biol. 2003;1:E20 pubmed
    ..2), SLC2A2 (GLUT2), HNF4A (HNF4alpha), and INS (insulin)-significantly altered disease risk, and in three genes, the risk ..

More Information

Publications121 found, 100 shown here

  1. Roncero I, Alvarez E, Chowen J, Sanz C, Rabano A, Vazquez P, et al. Expression of glucose transporter isoform GLUT-2 and glucokinase genes in human brain. J Neurochem. 2004;88:1203-10 pubmed
  2. Kilpeläinen T, Lakka T, Laaksonen D, Laukkanen O, Lindstrom J, Eriksson J, et al. Physical activity modifies the effect of SNPs in the SLC2A2 (GLUT2) and ABCC8 (SUR1) genes on the risk of developing type 2 diabetes. Physiol Genomics. 2007;31:264-72 pubmed
    Single nucleotide polymorphisms (SNPs) in two genes regulating insulin secretion, SLC2A2 (encoding GLUT2) and ABCC8 (encoding SUR1), were associated with the conversion from impaired glucose tolerance (IGT) to type 2 diabetes (T2D) in the ..
  3. Igl W, Johansson A, Wilson J, Wild S, Polasek O, Hayward C, et al. Modeling of environmental effects in genome-wide association studies identifies SLC2A2 and HP as novel loci influencing serum cholesterol levels. PLoS Genet. 2010;6:e1000798 pubmed publisher
    ..6 x 10(-5), p(SE,adjusted) = 2.2 x 10(-6), p(NS,unadjusted) = 0.047) in the SLC2A2 (Glucose transporter type 2) and rs2000999 (p(SE,unadjusted) = 1.1 x 10(-3), p(SE,adjusted) = 3...
  4. Jacometo C, Zhou Z, Luchini D, Trevisi E, Corrêa M, Loor J. Maternal rumen-protected methionine supplementation and its effect on blood and liver biomarkers of energy metabolism, inflammation, and oxidative stress in neonatal Holstein calves. J Dairy Sci. 2016;99:6753-6763 pubmed publisher
    ..1 (FBP1), phosphoenolpyruvate carboxykinase 1 (PCK1), and the facilitated bidirectional glucose transporter SLC2A2 in MET calves indicated alterations in gluconeogenesis and glucose uptake and release...
  5. Liao P, Liao M, Li L, Tan B, Yin Y. Effect of deoxynivalenol on apoptosis, barrier function, and expression levels of genes involved in nutrient transport, mitochondrial biogenesis and function in IPEC-J2 cells. Toxicol Res (Camb). 2017;6:866-877 pubmed publisher
    ..05), while the Na+-dependent neutral amino acid transporter 2 (ASCT2) and glucose transporter type 2 (GLUT2) showed a significant increase (P < 0.01)...
  6. Hong S, Lee J, Cho J, Kwon H, Park S, Rhee E, et al. Pioglitazone Attenuates Palmitate-Induced Inflammation and Endoplasmic Reticulum Stress in Pancreatic β-Cells. Endocrinol Metab (Seoul). 2018;33:105-113 pubmed publisher
    ..protein-1, prevented α-cell infiltration into the pancreatic islets, and upregulated glucose transporter 2 (Glut2) expression in β-cells...
  7. Liu Y, Song A, Zang S, Wang C, Song G, Li X, et al. Jinlida reduces insulin resistance and ameliorates liver oxidative stress in high-fat fed rats. J Ethnopharmacol. 2015;162:244-52 pubmed publisher
    ..substrate-1 (IRS-1), phosphoinositide-3-kinase (PI3K), protein kinase beta (AKT), and glucose transporter type 2 (GLUT2), were assessed by quantitative RT-PCR...
  8. Yin X, Liu H, Zhang Y. Mulberry branch bark powder significantly improves hyperglycemia and regulates insulin secretion in type II diabetic mice. Food Nutr Res. 2017;61:1368847 pubmed publisher
    ..which are related to glucose metabolism in the liver, and increase the expression of the genes PDX-1, GLUT2, MafA, and glucokinase, related to insulin secretion...
  9. Kang H, Lim W, Lee J, Ho J, Lim E, Cho H. Germinated Waxy Black Rice Ameliorates Hyperglycemia and Dyslipidemia in Streptozotocin-Induced Diabetic Rats. Biol Pharm Bull. 2017;40:1846-1855 pubmed publisher
    ..factor (HNF)-1?, HNF-1?, and HNF-4?, transcriptional factors that are involved in the regulation of SGLT1 and GLUT2, compared with the rats with STZ-induced diabetes that did not receive GWBR supplements...
  10. Iizuka K. The Role of Carbohydrate Response Element Binding Protein in Intestinal and Hepatic Fructose Metabolism. Nutrients. 2017;9: pubmed publisher
    ..ChREBP target genes are involved in glycolysis (Glut2, liver pyruvate kinase), fructolysis (Glut5, ketohexokinase), and lipogenesis (acetyl CoA carboxylase, fatty acid ..
  11. Huang M, Wang F, Zhou X, Yang H, Wang Y. Hypoglycemic and hypolipidemic properties of polysaccharides from Enterobacter cloacae Z0206 in KKAy mice. Carbohydr Polym. 2015;117:91-8 pubmed publisher
    ..adipose triglyceride lipase (ATGL), carnitine palmitoyl transferase 1-α (CPT1-α), glucose transporter 2 (Glut2), adenosine monophosphate activated protein kinase (AMPK) and silent information regulator 1 (Sirt1), but ..
  12. Gundala N, Naidu V, Das U. Arachidonic acid and lipoxin A4 attenuate alloxan-induced cytotoxicity to RIN5F cells in vitro and type 1 diabetes mellitus in vivo. Biofactors. 2017;43:251-271 pubmed publisher
    ..Expression of PDX1, P65 NF-kB and IKB in RIN5F cells and Nrf2, GLUT2, COX2, iNOS protein levels in the pancreatic tissue and plasma glucose, insulin and tumor necrosis factor-? and ..
  13. Faseleh Jahromi M, Wesam Altaher Y, Shokryazdan P, Ebrahimi R, Ebrahimi M, Idrus Z, et al. Dietary supplementation of a mixture of Lactobacillus strains enhances performance of broiler chickens raised under heat stress conditions. Int J Biometeorol. 2016;60:1099-110 pubmed publisher
    ..the two Lactobacillus strains significantly increased the expression of the four sugar transporter genes tested (GLUT2, GLUT5, SGLT1, and SGLT4) indicating probiotic enhances the absorption of this nutrient...
  14. Satoh T, Igarashi M, Yamada S, Takahashi N, Watanabe K. Inhibitory effect of black tea and its combination with acarbose on small intestinal α-glucosidase activity. J Ethnopharmacol. 2015;161:147-55 pubmed publisher
    ..JAT had no effect on the uptake of 2'-deoxy-d-glucose by glucose transporter 2 (GLUT2) and the uptake of α-methyl-d-glucose by sodium-dependent glucose transporter 1 (SGLT1)...
  15. Teixeira S, Panveloski Costa A, Carvalho A, Monteiro Schiavon F, Ruiz Marque A, Campello R, et al. Thyroid hormone treatment decreases hepatic glucose production and renal reabsorption of glucose in alloxan-induced diabetic Wistar rats. Physiol Rep. 2016;4: pubmed
    ..liver PEPCK, GAPDH, and pAKT expression, as well as urine glucose concentration and renal expression of SGLT2 and GLUT2. T3 reduced blood glucose, hepatic glucose production, liver PEPCK, GAPDH, and pAKT content and the renal ..
  16. Weber C, Schäff C, Kautzsch U, Borner S, Erdmann S, Bruckmaier R, et al. Variable liver fat concentration as a proxy for body fat mobilization postpartum has minor effects on insulin-induced changes in hepatic gene expression related to energy metabolism in dairy cows. J Dairy Sci. 2017;100:1507-1520 pubmed publisher
    ..and hydroxyl-methyl-glutaryl-CoA-synthase 1 increased, but the mRNA abundance of solute carrier family 2 (SLC2A2 and SLC2A4), growth hormone receptor 1A (GHR1A), insulin-like growth factor 1 (IGF1), sterol regulatory element ..
  17. Zhang Q, Yuan H, Zhang C, Guan Y, Wu Y, Ling F, et al. Epigallocatechin gallate improves insulin resistance in HepG2 cells through alleviating inflammation and lipotoxicity. Diabetes Res Clin Pract. 2018;142:363-373 pubmed publisher
    ..The glucose transporter 2 (GLUT2) protein and its downstream proteins peroxisome proliferator-activated receptor ? coactivator (PGC)-1? were ..
  18. Principi E, Buschiazzo A, Papait A, Castagnola P, Costa D, Pece R, et al. Anthropometric and glucometabolic changes in an aged mouse model of lipocalin-2 overexpression. Int J Obes (Lond). 2018;: pubmed publisher
    ..0122) and a statistically significant impaired glucose tolerance and insulin sensitivity consistent with Slc2a2 mRNA (P ≤ 0.0001) downregulated expression. On the other hand, Insr mRNA (P ≤ 0...
  19. Vallon V, Rose M, Gerasimova M, Satriano J, Platt K, Koepsell H, et al. Knockout of Na-glucose transporter SGLT2 attenuates hyperglycemia and glomerular hyperfiltration but not kidney growth or injury in diabetes mellitus. Am J Physiol Renal Physiol. 2013;304:F156-67 pubmed publisher
    ..The absence of SGLT2 did not affect renal mRNA expression of glucose transporters SGLT1, NaGLT1, GLUT1, or GLUT2 in response to STZ. Application of STZ increased blood glucose levels to a lesser extent in Sglt2(-/-) vs...
  20. Wu H, Liu Y, Wang H, Xu X. High-fat diet induced insulin resistance in pregnant rats through pancreatic pax6 signaling pathway. Int J Clin Exp Pathol. 2015;8:5196-202 pubmed
    ..factor-1 (Pdx1), v-maf musculoaponeurotic fibrosarcoma oncogene homolog A (MafA) and glucose transporter 2 (Glut2) were decreased significantly compared with those of normal control group...
  21. Vasu S, Ojo O, Moffett R, Conlon J, Flatt P, Abdel Wahab Y. Anti-diabetic actions of esculentin-2CHa(1-30) and its stable analogues in a diet-induced model of obesity-diabetes. Amino Acids. 2017;49:1705-1717 pubmed publisher
    ..Peptide treatments had beneficial effects on expression of islet genes (Ins1, Slc2a2, Pdx1) and skeletal muscle genes involved in insulin action (Slc2a4, Pdk1, Irs1, Akt1)...
  22. Maqbool F, Bahadar H, Niaz K, Baeeri M, Rahimifard M, Navaei Nigjeh M, et al. Effects of methyl mercury on the activity and gene expression of mouse Langerhans islets and glucose metabolism. Food Chem Toxicol. 2016;93:119-28 pubmed publisher
    ..MeHg disrupted gluconeogenesis/glycogenolysis pathways and insulin secretory functions of islets by targeting GDH, GLUT2 and GCK genes of pancreatic islets...
  23. Ali M, Eid R, Hanafi M. Vitamin C and E chronic supplementation differentially affect hepatic insulin signaling in rats. Life Sci. 2018;194:196-204 pubmed publisher
    ..its effect downstream insulin receptor in the insulin signaling pathway, reducing hepatic glucose transporter-2 (GLUT2) and phosphorylated protein kinase (p-Akt)...
  24. Antu K, Riya M, Nair A, Mishra A, Srivastava A, Raghu K. Symplocos cochinchinensis enhances insulin sensitivity via the down regulation of lipogenesis and insulin resistance in high energy diet rat model. J Ethnopharmacol. 2016;193:500-509 pubmed publisher
    ..synthase (FAS), glucose 6 phosphatase (G6Pase), phosphoenol pyruvate carboxykinase (PEPCK), glucose transporter 2 (GLUT2), protein tyrosine phosphatse 1B (PTP1B), peroxisome proliferator activated receptor alpha (PPAR alpha), sirtuin 1 ..
  25. Okauchi S, Shimoda M, Obata A, Kimura T, Hirukawa H, Kohara K, et al. Protective effects of SGLT2 inhibitor luseogliflozin on pancreatic β-cells in obese type 2 diabetic db/db mice. Biochem Biophys Res Commun. 2016;470:772-782 pubmed publisher
    ..Furthermore, in gene analysis using isolated islets, insulin 1, insulin 2, MafA, PDX-1 and GLUT2 gene expression levels were significantly higher in Luse groups compared to control group...
  26. Ding Y, Tian Y, Guo M, Liu J, Heng D, Zhu B, et al. Regulation of glucose transport by thyroid hormone in rat ovary. Cell Tissue Res. 2016;366:455-466 pubmed publisher
    ..In contrast, L-thyroxine significantly increased Glut4 mRNA level and protein content but had little effect on Glut2 and Glut3 expression...
  27. Kinoshita A, Kenéz Ã, Locher L, Meyer U, Dänicke S, Rehage J, et al. Insulin Signaling in Liver and Adipose Tissues in Periparturient Dairy Cows Supplemented with Dietary Nicotinic Acid. PLoS ONE. 2016;11:e0147028 pubmed publisher
    ..involved in hepatic and adipose insulin signaling and protein expression of hepatic glucose transporter 2 (GLUT2) were affected by dietary NA and dietary concentrate intake in periparturient dairy cows...
  28. Mi Y, Zhang W, Tian H, Li R, Huang S, Li X, et al. EGCG evokes Nrf2 nuclear translocation and dampens PTP1B expression to ameliorate metabolic misalignment under insulin resistance condition. Food Funct. 2018;9:1510-1523 pubmed publisher
    ..Our results indicated that EGCG accelerates the glucose uptake and evokes IRS-1/Akt/GLUT2 signaling pathway via dampening the expression of protein tyrosine phosphatase 1B (PTP1B)...
  29. Volkov P, Bacos K, Ofori J, Esguerra J, Eliasson L, Rönn T, et al. Whole-Genome Bisulfite Sequencing of Human Pancreatic Islets Reveals Novel Differentially Methylated Regions in Type 2 Diabetes Pathogenesis. Diabetes. 2017;66:1074-1085 pubmed publisher
    ..We also identified 457 genes, including NR4A3, PARK2, PID1, SLC2A2, and SOCS2, that had both DMRs and significant expression changes in T2D islets...
  30. Solini A, Sebastiani G, Nigi L, Santini E, Rossi C, Dotta F. Dapagliflozin modulates glucagon secretion in an SGLT2-independent manner in murine alpha cells. Diabetes Metab. 2017;43:512-520 pubmed publisher
    ..GLUT1 and GLUT2, as well as regulators of glucagon release and alpha-cell phenotype (chromogranin A, paired box 6, proprotein ..
  31. Segev H, Fishman B, Schulman R, Itskovitz Eldor J. The expression of the class 1 glucose transporter isoforms in human embryonic stem cells, and the potential use of GLUT2 as a marker for pancreatic progenitor enrichment. Stem Cells Dev. 2012;21:1653-61 pubmed publisher
    ..We also examined the potential use of GLUT2 as a marker for differentiating pancreatic progenitor cells...
  32. Franssens L, Lesuisse J, Wang Y, Willems E, Willemsen H, Koppenol A, et al. The effect of insulin on plasma glucose concentrations, expression of hepatic glucose transporters and key gluconeogenic enzymes during the perinatal period in broiler chickens. Gen Comp Endocrinol. 2016;232:67-75 pubmed publisher
    ..In addition, at the minimum plasma glucose level seven hours post-injection (PI), hepatic GLUT2, FBP1 and PCK2 mRNA abundance was decreased in insulin-injected embryos, compared to sham and control groups, ..
  33. Hirata T, Yoshitomi T, Inoue M, Iigo Y, Matsumoto K, Kubota K, et al. Pathological and gene expression analysis of a polygenic diabetes model, NONcNZO10/LtJ mice. Gene. 2017;629:52-58 pubmed publisher
    ..regulated by miR-29a/b) were observed, and zinc homeostasis (Slc30a8, Mt1 and Mt2) or glucose metabolism (Slc2a2) was suggested as being the candidate mechanism of pancreas failure in NONcNZO10/LtJ mice...
  34. Mohd Fauzi F, John C, Karunanidhi A, Mussa H, Ramasamy R, Adam A, et al. Understanding the mode-of-action of Cassia auriculata via in silico and in vivo studies towards validating it as a long term therapy for type II diabetes. J Ethnopharmacol. 2017;197:61-72 pubmed publisher
    ..28 days and the expression levels of genes regulating insulin signalling pathway, glucose transporters of hepatic (GLUT2) and muscular (GLUT4) tissue, insulin receptor substrate (IRS), phosphorylated insulin receptor (AKT), ..
  35. Hinden L, Udi S, Drori A, Gammal A, Nemirovski A, Hadar R, et al. Modulation of Renal GLUT2 by the Cannabinoid-1 Receptor: Implications for the Treatment of Diabetic Nephropathy. J Am Soc Nephrol. 2018;29:434-448 pubmed publisher
    Altered glucose reabsorption via the facilitative glucose transporter 2 (GLUT2) during diabetes may lead to renal proximal tubule cell (RPTC) injury, inflammation, and interstitial fibrosis...
  36. Nishimura W, Kapoor A, El Khattabi I, Jin W, Yasuda K, Bonner Weir S, et al. Compensatory Response by Late Embryonic Tubular Epithelium to the Reduction in Pancreatic Progenitors. PLoS ONE. 2015;10:e0142286 pubmed publisher
    ..endocrine cells resulted from a higher proliferation of tubular epithelial cells expressing the progenitor marker Glut2 in E17.5 bigenic embryos and increased number of Neurog3-expressing cells at E19.5...
  37. Abbasi N, Purslow P, Tosh S, Bakovic M. Oat β-glucan depresses SGLT1- and GLUT2-mediated glucose transport in intestinal epithelial cells (IEC-6). Nutr Res. 2016;36:541-52 pubmed publisher
    ..expressions of glucose transporters sodium-glucose-linked transport protein 1 (SGLT1) and glucose transporter 2 (GLUT2) increased with time (0-60 minutes) and glucose levels (5-25 mmol/L)...
  38. Liang X, Giacomini K. Transporters Involved in Metformin Pharmacokinetics and Treatment Response. J Pharm Sci. 2017;106:2245-2250 pubmed publisher
    ..Furthermore, a recent genome-wide association study in a large multi-ethnic population implicated polymorphisms in SLC2A2, encoding the glucose transporter, GLUT2, as important determinants of response to metformin...
  39. Meneses M, Bernardino R, Sa R, Silva J, Barros A, Sousa M, et al. Pioglitazone increases the glycolytic efficiency of human Sertoli cells with possible implications for spermatogenesis. Int J Biochem Cell Biol. 2016;79:52-60 pubmed publisher
    ..Protein levels of phosphofructokinase 1, lactate dehydrogenase, hexokinase, glucose transporters (GLUT1, GLUT2, GLUT3), monocarboxylate transporter 4 and oxidative phosphorylation complexes were determined by Western blot...
  40. Elsner M, Tiedge M, Lenzen S. Mechanism underlying resistance of human pancreatic beta cells against toxicity of streptozotocin and alloxan. Diabetologia. 2003;46:1713-4 pubmed
  41. Song M, Wang J, Ka S, Bae E, Park B. Insulin secretion impairment in Sirt6 knockout pancreatic β cells is mediated by suppression of the FoxO1-Pdx1-Glut2 pathway. Sci Rep. 2016;6:30321 pubmed publisher
    ..its nuclear export and releases its transcriptional repression of key glucose sensing genes such as Pdx1 and Glut2. Ectopic overexpression of Sirt6 in knockout islets resulted in rescue of the defective insulin secretion and ..
  42. Daci A, Bozalija A, Jashari F, Krasniqi S. Individualizing Treatment Approaches for Epileptic Patients with Glucose Transporter Type1 (GLUT-1) Deficiency. Int J Mol Sci. 2018;19: pubmed publisher
    ..variation in solute carrier family 2, facilitated glucose transporter member 1 (SLC2A1) and mutations of the GLUT1/SLC2A2 gene results in the failure of glucose transport, which is related with a glucose type-1 transporter (GLUT1) ..
  43. Lyu J, Imachi H, Yoshimoto T, Fukunaga K, Sato S, Ibata T, et al. Thyroid stimulating hormone stimulates the expression of glucose transporter 2 via its receptor in pancreatic β cell line, INS-1 cells. Sci Rep. 2018;8:1986 pubmed publisher
    ..TSH directly affected the glucose uptake in INS cells by up-regulating the expression of GLUT2, and furthermore this process was blocked by SB203580, the specific inhibitor of the p38 MAPK signaling pathway...
  44. Su Z, Du M, Chen H, Chen Q, Yu C, Mal H. Two cases of Fanconi-Bickel syndrome: first report from China with novel mutations of SLC2A2 gene. J Pediatr Endocrinol Metab. 2011;24:749-53 pubmed
    Fanconi-Bickel syndrome (FBS) is a rare inherited disease caused by mutations in the glucose transporter 2 gene, SLC2A2. We reported the first two Chinese cases of FBS...
  45. Grefner N, Gromova L, Gruzdkov A, Komissarchik I. [The interaction between SGLT1 or GLUT2 glucose transporter and the cytoskeleton in the enterocyte as well as Caco2 cell during hexose absorption]. Tsitologiia. 2014;56:749-57 pubmed
    The distribution of cytoskeleton elements (microtubules and actin filaments) and SGLT1 or GLUT2 glucose transporter in enterocyte of rat intestine and Caco2 cell during hexose absorption has been considered...
  46. Ding Y, Xian X, Holland W, TSAI S, Herz J. Low-Density Lipoprotein Receptor-Related Protein-1 Protects Against Hepatic Insulin Resistance and Hepatic Steatosis. EBioMedicine. 2016;7:135-45 pubmed publisher
    ..resistance, reduced expression of insulin receptors on the hepatocyte surface and decreased glucose transporter 2 (GLUT2) translocation...
  47. Kim G, Shin K, Pae E. Zinc Up-Regulates Insulin Secretion from ? Cell-Like Cells Derived from Stem Cells from Human Exfoliated Deciduous Tooth (SHED). Int J Mol Sci. 2016;17: pubmed
    ..at day 10 increased the levels of most pancreatic ? cell markers-particularly Insulin and glucose transporter 2 (GLUT2). We confirmed that SHED-? cells produce insulin successfully...
  48. Norton L, Shannon C, Fourcaudot M, Hu C, Wang N, Ren W, et al. Sodium-glucose co-transporter (SGLT) and glucose transporter (GLUT) expression in the kidney of type 2 diabetic subjects. Diabetes Obes Metab. 2017;19:1322-1326 pubmed publisher
    ..In contrast, our data demonstrate that the levels of SGLT2 and GLUT2 mRNA are downregulated in diabetic patients, but not to a statistically significant level...
  49. Kang O, Shon M, Kong R, Seo Y, Zhou T, Kim D, et al. Anti-diabetic effect of black ginseng extract by augmentation of AMPK protein activity and upregulation of GLUT2 and GLUT4 expression in db/db mice. BMC Complement Altern Med. 2017;17:341 pubmed publisher
    ..Moreover, GBG05-FF increased the phosphorylation of the AMPK in the liver and upregulated the expression of GLUT2 in liver and GLUT4 in muscle...
  50. Neelankal John A, Ram R, Jiang F. RNA-Seq Analysis of Islets to Characterise the Dedifferentiation in Type 2 Diabetes Model Mice db/db. Endocr Pathol. 2018;29:207-221 pubmed publisher
    ..A reduction in both insulin secretion and the expression of Ins1, Ins2, Glut2, Pdx1 and MafA was indicative of dedifferentiation in db/db islets...
  51. Chen L, Tuo B, Dong H. Regulation of Intestinal Glucose Absorption by Ion Channels and Transporters. Nutrients. 2016;8: pubmed publisher
    ..lumen into enterocytes is the Na⁺/glucose cotransporter (SGLT1), although glucose transporter type 2 (GLUT2) may also play a role...
  52. Adamu H, Imam M, Ooi D, Esa N, Rosli R, Ismail M. Perinatal exposure to germinated brown rice and its gamma amino-butyric acid-rich extract prevents high fat diet-induced insulin resistance in first generation rat offspring. Food Nutr Res. 2016;60:30209 pubmed publisher
    ..assessment of insulin resistance, leptin, oxidative stress, and RBP4 levels, while their hepatic mRNA levels of GLUT2 and IPF1 were increased...
  53. Tsytkin Kirschenzweig S, Cohen M, Nahmias Y. Tracking GLUT2 Translocation by Live-Cell Imaging. Methods Mol Biol. 2018;1713:241-254 pubmed publisher
    ..The facilitative GLUT2 transporter is uniquely expressed in metabolic epithelial cells of the intestine, pancreas, liver, and kidney...
  54. McVie Wylie A, Lamson D, Chen Y. Molecular cloning of a novel member of the GLUT family of transporters, SLC2a10 (GLUT10), localized on chromosome 20q13.1: a candidate gene for NIDDM susceptibility. Genomics. 2001;72:113-7 pubmed
    ..From these data, we believe that the chromosomal localization, tissue distribution, and predicted function make GLUT10 an excellent candidate for a susceptibility gene involved in NIDDM. ..
  55. Xiong X, Li Q, Cui W, Gao Z, Liu J. Deteriorated high-fat diet-induced diabetes caused by pancreatic ?-cell-specific overexpression of Reg3? gene in mice. Endocrine. 2016;54:360-370 pubmed
    ..Glucose and insulin tolerance tests, immunofluorescence for insulin, eIF2?, and GLUT2 in islets, Western blots on phosphorylated AMPK? and hepatic histology were performed...
  56. Williams A, Hansen T, Krych L, Ahmad H, Nielsen D, Skovgaard K, et al. Dietary cinnamaldehyde enhances acquisition of specific antibodies following helminth infection in pigs. Vet Immunol Immunopathol. 2017;189:43-52 pubmed publisher
    ..of genes encoding the B-cell marker CD19, sodium/glucose co-transporter1 (SCA5L1) and glucose transporter 2 (SLC2A2) in the jejunal mucosa of A.suum-infected pigs...
  57. Sakamoto O, Ogawa E, Ohura T, Igarashi Y, Matsubara Y, Narisawa K, et al. Mutation analysis of the GLUT2 gene in patients with Fanconi-Bickel syndrome. Pediatr Res. 2000;48:586-9 pubmed
    ..Several mutations in a gene encoding a glucose transporter, GLUT2, have recently been reported in patients with FBS...
  58. Liu Y, Pu Q, Wu M, Yu C. Proteomic analysis for the impact of hypercholesterolemia on expressions of hepatic drug transporters and metabolizing enzymes. Xenobiotica. 2016;46:940-7 pubmed publisher
    ..Among those, protein levels of hepatic drug transporters (MRP2, ABCD3, OAT2, SLC25A12, SCL38A3, SLC2A2 and SLC25A5) and metabolizing enzymes (CYP2B3, CYP2C7, CYP2C11, CYP2C13, CYP4A2 and UGT2B) were markedly reduced, ..
  59. Cha J, Kim H, Kim H, Im S, Kim S, Kim J, et al. Analysis of polymorphism of the GLUT2 promoter in NIDDM patients and its functional consequence to the promoter activity. Ann Clin Lab Sci. 2002;32:114-22 pubmed
    Glucose transporter type 2 (GLUT2), along with glucokinase, has been implicated to participate in glucose-induced insulin secretion in pancreatic beta-cells...
  60. Lahmy R, Soleimani M, Sanati M, Behmanesh M, Kouhkan F, Mobarra N. Pancreatic islet differentiation of human embryonic stem cells by microRNA overexpression. J Tissue Eng Regen Med. 2016;10:527-34 pubmed publisher
    ..1, Glut2 and insulin, were detected by quantitative real-time PCR...
  61. Sun W, Zhang B, Zheng H, Zhuang C, Li X, Lu X, et al. Trivaric acid, a new inhibitor of PTP1b with potent beneficial effect on diabetes. Life Sci. 2017;169:52-64 pubmed publisher
    ..Trivaric acid also enhanced the ability of insulin to stimulate the IR/IRS/Akt/GLUT2 pathway and increase the glucose consumption in HepG2 cells...
  62. Meier S, Mattheisen M, Vassos E, Strohmaier J, Treutlein J, Josef F, et al. Genome-wide significant association between a 'negative mood delusions' dimension in bipolar disorder and genetic variation on chromosome 3q26.1. Transl Psychiatry. 2012;2:e165 pubmed publisher
    ..1 and in the vicinity of the solute carrier family 2 (facilitated glucose transporter), member 2 gene (SLC2A2), was significantly associated with the factor analysis-derived dimension 'negative mood delusions' (n=927; P=4...
  63. Fukumoto H, Seino S, Imura H, Seino Y, Eddy R, Fukushima Y, et al. Sequence, tissue distribution, and chromosomal localization of mRNA encoding a human glucose transporter-like protein. Proc Natl Acad Sci U S A. 1988;85:5434-8 pubmed
    ..The single-copy gene encoding this glucose transporter-like protein has been localized to the q26.1----q26.3 region of chromosome 3. ..
  64. Mariggio S, Iurisci C, Sebastia J, Patton Vogt J, Corda D. Molecular characterization of a glycerophosphoinositol transporter in mammalian cells. FEBS Lett. 2006;580:6789-96 pubmed
    ..Such a transporter, GIT1, has been cloned in yeast. By PSI-BLAST analysis, we have identified the Glut2 transporter as a human-genome candidate ortholog of GIT1...
  65. Willer C, Bonnycastle L, Conneely K, Duren W, Jackson A, Scott L, et al. Screening of 134 single nucleotide polymorphisms (SNPs) previously associated with type 2 diabetes replicates association with 12 SNPs in nine genes. Diabetes. 2007;56:256-64 pubmed
    ..05) for 12 SNPs: PPARG Pro12Ala and His447, KCNJ11 Glu23Lys and rs5210, TNF -857, SLC2A2 Ile110Thr, HNF1A/TCF1 rs2701175 and GE117881_360, PCK1 -232, NEUROD1 Thr45Ala, IL6 -598, and ENPP1 Lys121Gln...
  66. Freitas H, D Agord Schaan B, da Silva R, Okamoto M, Oliveira Souza M, Machado U. Insulin but not phlorizin treatment induces a transient increase in GLUT2 gene expression in the kidney of diabetic rats. Nephron Physiol. 2007;105:p42-51 pubmed
    ..Here we investigate the GLUT2 gene expression changes in the kidney of diabetic rats, by using insulin or phlorizin treatment...
  67. Im S, Kim S, Kim H, Ahn Y. Transcriptional regulation of glucose sensors in pancreatic beta cells and liver. Curr Diabetes Rev. 2006;2:11-8 pubmed
    ..Glucose also acts as a key signal in pancreatic beta-cells for regulating insulin secretion. Because GLUT2 and GK expressed in liver and beta-cells are responsible for sensing glucose levels in the blood, studies on the ..
  68. Beamish C, Strutt B, Arany E, Hill D. Insulin-positive, Glut2-low cells present within mouse pancreas exhibit lineage plasticity and are enriched within extra-islet endocrine cell clusters. Islets. 2016;8:65-82 pubmed publisher
    ..islets suggest that the HPAP(+)Ck19(+) cells had derived from insulin-positive, glucose-transporter-2-low (Ins(+)Glut2(LO)) cells, representing 3.5% of all insulin-expressing cells...
  69. Zhao P, Wendt D, Goodin S, Ravichandran S, Chouinard T, Strader A. Adaptation of Intestinal and Bile Acid Physiology Accompany the Metabolic Benefits Following Ileal Interposition in the Rat. Obes Surg. 2018;28:725-734 pubmed publisher
    ..The interposed segment becomes jejunized in its new location as indicated by an increase in Glut2 and Pepck mRNA, genes predominantly synthesized within the jejunum...
  70. Udoh U, Valcin J, Swain T, Filiano A, Gamble K, Young M, et al. Genetic deletion of the circadian clock transcription factor BMAL1 and chronic alcohol consumption differentially alter hepatic glycogen in mice. Am J Physiol Gastrointest Liver Physiol. 2017;:ajpgi.00281.2017 pubmed publisher
    ..Alcohol consumption significantly altered Gck, Glut2, and Ppp1r3g rhythms in livers of control genotype mice, with diurnal rhythms of Pklr, Glut2
  71. Takeda J, Kayano T, Fukomoto H, Bell G. Organization of the human GLUT2 (pancreatic beta-cell and hepatocyte) glucose transporter gene. Diabetes. 1993;42:773-7 pubmed
    ..the predominant facilitative glucose transporter expressed in pancreatic beta-cells and hepatocytes, termed GLUT2, has been cloned and characterized...
  72. Borglykke A, Grarup N, Sparsø T, Linneberg A, Fenger M, Jeppesen J, et al. Genetic variant SLC2A2 [corrected] Is associated with risk of cardiovascular disease – assessing the individual and cumulative effect of 46 type 2 diabetes related genetic variants. PLoS ONE. 2012;7:e50418 pubmed publisher
    ..gene variants were significantly associated with incident CVD independently of known diabetes status at baseline; SLC2A2 rs11920090 (HR 1.147, 95% CI 1.027-1.283 , P = 0.0154), C2CD4A rs7172432 (1.112, 1.027-1.205 , P = 0...
  73. Al Wakeel R, Shukry M, Abdel Azeez A, Mahmoud S, Saad M. Alleviation by gamma amino butyric acid supplementation of chronic heat stress-induced degenerative changes in jejunum in commercial broiler chickens. Stress. 2017;20:562-572 pubmed publisher
    ..GABA supplementation significantly modulated HS-induced changes in glucose facilitated transporter 2 (GLUT2), peptide transporter 1 (PEPT1) and heat shock protein 70 (HSP70) mRNA expression in the jejunal mucosa (p?<?...
  74. Kruse M, Suarez L, Coirini H. LXR activation increases the expression of GnRH AND αMSH in the rat hypothalamus in vivo. Neurosci Lett. 2018;664:20-27 pubmed publisher
    ..As a positive control the cholesterol ABCA1 and glucose GLUT2 transporters were used. No changes were observed in the expression of the factors evaluated in vitro...
  75. Santer R, Schneppenheim R, Dombrowski A, Gotze H, Steinmann B, Schaub J. Fanconi-Bickel syndrome--a congenital defect of the liver-type facilitative glucose transporter. SSIEM Award. Society for the Study of Inborn Errors of Metabolism. J Inherit Metab Dis. 1998;21:191-4 pubmed
  76. Ban N, Yamada Y, Someya Y, Miyawaki K, Ihara Y, Hosokawa M, et al. Hepatocyte nuclear factor-1alpha recruits the transcriptional co-activator p300 on the GLUT2 gene promoter. Diabetes. 2002;51:1409-18 pubmed
    ..Here we show that the human GLUT2 gene is closely regulated by HNF-1alpha via sequences downstream of the transcriptional start site by interaction ..
  77. Guillemain G, Munoz Alonso M, Cassany A, Loizeau M, Faussat A, Burnol A, et al. Karyopherin alpha2: a control step of glucose-sensitive gene expression in hepatic cells. Biochem J. 2002;364:201-9 pubmed
    Glucose is required for an efficient expression of the glucose transporter GLUT2 and other genes...
  78. Michau A, Guillemain G, Grosfeld A, Vuillaumier Barrot S, Grand T, Keck M, et al. Mutations in SLC2A2 gene reveal hGLUT2 function in pancreatic ? cell development. J Biol Chem. 2013;288:31080-92 pubmed publisher
    The structure-function relationships of sugar transporter-receptor hGLUT2 coded by SLC2A2 and their impact on insulin secretion and ? cell differentiation were investigated through the detailed characterization of a panel of mutations ..
  79. Vionnet N, Tregouet D, Kazeem G, Gut I, Groop P, Tarnow L, et al. Analysis of 14 candidate genes for diabetic nephropathy on chromosome 3q in European populations: strongest evidence for association with a variant in the promoter region of the adiponectin gene. Diabetes. 2006;55:3166-74 pubmed
    ..Polymorphisms in three genes, glucose transporter 2 (SLC2A2), kininogen (KNG1), and adiponectin (ADIPOQ), showed nominal association with diabetic nephropathy in single-point ..
  80. Yamanaka T, Tashima K, Takahashi R, Takashima S, Goto T, Hirabayashi M, et al. Direct comparison of Cryotop® vitrification and Bicell® freezing on recovery of functional rat pancreatic islets. Cryobiology. 2016;73:376-382 pubmed publisher
    ..that Bicell® freeze-thawing compromised expression of genes relating to β-cell function (Pdx1 and Glut2), but not to one of apoptotic pathways (Bax/Bcl2 ratio)...
  81. Coskun E, Ercin M, Gezginci Oktayoglu S. The Role of Epigenetic Regulation and Pluripotency-Related MicroRNAs in Differentiation of Pancreatic Stem Cells to Beta Cells. J Cell Biochem. 2018;119:455-467 pubmed publisher
    ..1, NGN3, INS2, and GLUT2. As a result the valproic acid, is an inhibitor of class-I HDACs, caused the highest beta cell differentiation in ..
  82. Khandelwal P, Sinha A, Jain V, Houghton J, Hari P, Bagga A. Fanconi syndrome and neonatal diabetes: phenotypic heterogeneity in patients with GLUT2 defects. CEN Case Rep. 2018;7:1-4 pubmed publisher
    Fanconi-Bickel syndrome, caused by mutations in SLC2A2 encoding the glucose transporter 2 (GLUT2), is characterized by generalized proximal renal tubular dysfunction manifesting in late infancy...
  83. Casanova L, Gu W, Costa S, Jeppesen P. Phenolic Substances from Ocimum Species Enhance Glucose-Stimulated Insulin Secretion and Modulate the Expression of Key Insulin Regulatory Genes in Mice Pancreatic Islets. J Nat Prod. 2017;: pubmed publisher
    ..insulin regulatory genes INS1, INS2, PDX1, INSR, IRS1, and proliferative genes as well as glucose transporter 2 (GLUT2), in treated islets. Thus, they may play an important role in diabetes treatment...
  84. Wu L, Fritz J, Powers A. Different functional domains of GLUT2 glucose transporter are required for glucose affinity and substrate specificity. Endocrinology. 1998;139:4205-12 pubmed
    b>GLUT2 is the major glucose transporter in pancreatic beta-cells and hepatocytes. It plays an important role in insulin secretion from beta-cells and glucose metabolism in hepatocytes...
  85. Zheng Y, Scow J, Duenes J, Sarr M. Mechanisms of glucose uptake in intestinal cell lines: role of GLUT2. Surgery. 2012;151:13-25 pubmed publisher
    b>GLUT2 is translocated to the apical membrane of enterocytes exposed to glucose concentrations >?50 mM. Mechanisms of GLUT2-mediated glucose uptake in cell culture models of enterocytes have not been studied...
  86. Szablewski L. Glucose Transporters in Brain: In Health and in Alzheimer's Disease. J Alzheimers Dis. 2017;55:1307-1320 pubmed publisher
    ..as the compensatory mechanisms in AD are the utilization of endogenous brain substances and drastic increase in GLUT2 levels. The present review focuses on the changes in the expression of glucose transporters due to AD.
  87. Sinha N, Suárez Diez M, van Schothorst E, Keijer J, Martins Dos Santos V, Hooiveld G. Predicting the murine enterocyte metabolic response to diets that differ in lipid and carbohydrate composition. Sci Rep. 2017;7:8784 pubmed publisher
    ..sodium as a limiting factor for active glucose absorption; necessity of apical localization of glucose transporter GLUT2 for absorption of all glucose in the postprandial state; potential for gluconeogenesis in enterocytes; and the ..
  88. Labouèbe G, Thorens B, Lamy C. GLUT2-Expressing Neurons as Glucose Sensors in the Brain: Electrophysiological Analysis. Methods Mol Biol. 2018;1713:255-267 pubmed publisher
    ..Recent publications report that neurons expressing glucose transporter GLUT2 act as glucose sensors in different regions of the brain and contribute to the control of glucose homeostasis and ..
  89. Qin C, Yang L, Zheng W, Yan X, Lu R, Xie D, et al. Effects of dietary glucose and sodium chloride on intestinal glucose absorption of common carp (Cyprinus carpio L.). Biochem Biophys Res Commun. 2018;495:1948-1955 pubmed publisher
    ..showed that food intake greatly enhanced sodium/glucose cotransporter 1 (SGLT1) and glucose transporter type 2 (GLUT2) expressions, and improved glucose absorption, with highest levels at 09:00 a.m....
  90. Corpe C, Eck P, Wang J, Al Hasani H, Levine M. Intestinal dehydroascorbic acid (DHA) transport mediated by the facilitative sugar transporters, GLUT2 and GLUT8. J Biol Chem. 2013;288:9092-101 pubmed publisher
    ..Using Xenopus oocyte expression, we investigated whether facilitative glucose transporters GLUT2 and GLUT5-12 transported DHA...
  91. Ramzy A, Mojibian M, Kieffer T. Insulin-Deficient Mouse β-Cells Do Not Fully Maturebut Can Be Remedied Through Insulin Replacementby Islet Transplantation. Endocrinology. 2018;159:83-102 pubmed publisher
    ..Our findings suggest that tightly regulated glycemia, insulin species, or other islet factors are necessary for β-cell maturation. ..