SIRT1

Summary

Gene Symbol: SIRT1
Description: sirtuin 1
Alias: SIR2, SIR2L1, SIR2alpha, NAD-dependent protein deacetylase sirtuin-1, SIR2-like protein 1, regulatory protein SIR2 homolog 1, sirtuin type 1
Species: human
Products:     SIRT1

Top Publications

  1. Oppenheimer H, Gabay O, Meir H, Haze A, Kandel L, Liebergall M, et al. 75-kd sirtuin 1 blocks tumor necrosis factor α-mediated apoptosis in human osteoarthritic chondrocytes. Arthritis Rheum. 2012;64:718-28 pubmed publisher
    Sirtuin 1 (SirT1) has been implicated in the regulation of human cartilage homeostasis and chondrocyte survival...
  2. Walker A, Yang F, Jiang K, Ji J, Watts J, Purushotham A, et al. Conserved role of SIRT1 orthologs in fasting-dependent inhibition of the lipid/cholesterol regulator SREBP. Genes Dev. 2010;24:1403-17 pubmed publisher
    ..We demonstrate here a conserved role for orthologs of the NAD(+)-dependent deacetylase SIRT1 in metazoans in down-regulation of SREBP orthologs during fasting, resulting in inhibition of lipid synthesis and ..
  3. Purushotham A, Schug T, Xu Q, Surapureddi S, Guo X, Li X. Hepatocyte-specific deletion of SIRT1 alters fatty acid metabolism and results in hepatic steatosis and inflammation. Cell Metab. 2009;9:327-38 pubmed publisher
    ..b>SIRT1, a NAD+-dependent protein deacetylase, is an important regulator of energy homeostasis in response to nutrient ..
  4. Zannini L, Buscemi G, Kim J, Fontanella E, Delia D. DBC1 phosphorylation by ATM/ATR inhibits SIRT1 deacetylase in response to DNA damage. J Mol Cell Biol. 2012;4:294-303 pubmed publisher
    ..is a nuclear protein that, in response to DNA damage, competitively inhibits the NAD(+)-dependent deacetylase SIRT1, a regulator of p53 apoptotic functions in response to genotoxic stress...
  5. Abdelmohsen K, Pullmann R, Lal A, Kim H, Galban S, Yang X, et al. Phosphorylation of HuR by Chk2 regulates SIRT1 expression. Mol Cell. 2007;25:543-57 pubmed
    ..that HuR associated with the 3' untranslated region of the mRNA encoding the longevity and stress-response protein SIRT1, stabilized the SIRT1 mRNA, and increased SIRT1 expression levels...
  6. Maeda S, Koya D, Araki S, Babazono T, Umezono T, Toyoda M, et al. Association between single nucleotide polymorphisms within genes encoding sirtuin families and diabetic nephropathy in Japanese subjects with type 2 diabetes. Clin Exp Nephrol. 2011;15:381-390 pubmed publisher
    ..We examined 52 SNPs within the SIRT genes (11 in SIRT1, 7 in SIRT2, 14 in SIRT3, 7 in SIRT4, 9 in SIRT5, and 4 in SIRT6) in 3 independent Japanese populations with type ..
  7. Milner J. Cellular regulation of SIRT1. Curr Pharm Des. 2009;15:39-44 pubmed
    ..A key player amongst these is SIRT1, a member of the mammalian sirtuin family (SIRT1-7)...
  8. Wang R, Sengupta K, Li C, Kim H, Cao L, Xiao C, et al. Impaired DNA damage response, genome instability, and tumorigenesis in SIRT1 mutant mice. Cancer Cell. 2008;14:312-23 pubmed publisher
    ..Here we mutated the Sirt1 gene, a homolog of yeast Sir2, in mice to study its function...
  9. Dong Y, Guo T, Traurig M, Mason C, Kobes S, Perez J, et al. SIRT1 is associated with a decrease in acute insulin secretion and a sex specific increase in risk for type 2 diabetes in Pima Indians. Mol Genet Metab. 2011;104:661-5 pubmed publisher
    Genetic variation in SIRT1 affects obesity-related phenotypes in several populations...

More Information

Publications76

  1. Lee C, Wong L, Tse E, Liu H, Leong V, Lee J, et al. AMPK promotes p53 acetylation via phosphorylation and inactivation of SIRT1 in liver cancer cells. Cancer Res. 2012;72:4394-404 pubmed publisher
    ..The p53 deacetylase, SIRT1, was phosphorylated and inactivated by AMPK at Thr344, promoting p53 acetylation and apoptosis of HCC cells...
  2. Revollo J, Li X. The ways and means that fine tune Sirt1 activity. Trends Biochem Sci. 2013;38:160-7 pubmed publisher
    b>Sirt1 is the most evolutionarily conserved mammalian sirtuin. It plays a vital role in the regulation of metabolism, stress responses, genome stability, and ultimately aging...
  3. Yuan J, Luo K, Liu T, Lou Z. Regulation of SIRT1 activity by genotoxic stress. Genes Dev. 2012;26:791-6 pubmed publisher
    b>SIRT1 regulates a variety of cellular functions, including cellular stress responses and energy metabolism. SIRT1 activity is negatively regulated by DBC1 (Deleted in Breast Cancer 1) through direct binding...
  4. Clark S, Falchi M, Olsson B, Jacobson P, Cauchi S, Balkau B, et al. Association of sirtuin 1 (SIRT1) gene SNPs and transcript expression levels with severe obesity. Obesity (Silver Spring). 2012;20:178-85 pubmed publisher
    Recent studies have reported associations of sirtuin 1 (SIRT1) single nucleotide polymorphisms (SNPs) to both obesity and BMI. This study was designed to investigate association between SIRT1 SNPs, SIRT1 gene expression and obesity...
  5. Sung J, Kim R, Kim J, Lee J. Balance between SIRT1 and DBC1 expression is lost in breast cancer. Cancer Sci. 2010;101:1738-44 pubmed publisher
    b>SIRT1 (silent mating-type information regulation 2 homologue 1)-mediated cellular resistance to various stresses is negatively regulated by deleted in breast cancer 1 (DBC1), which was originally reported to be deleted in breast cancer...
  6. Kang H, Suh J, Jung Y, Jung J, Kim M, Chung J. Peptide switch is essential for Sirt1 deacetylase activity. Mol Cell. 2011;44:203-13 pubmed publisher
    In mammals, the Sirtuins are composed of seven Sir2 orthologs (Sirt1-7) with a conserved deacetylase core that utilizes NAD(+) as a cofactor. Interestingly, the deacetylase core of Sirt1 by itself has no catalytic activity...
  7. Gagarina V, Gabay O, Dvir Ginzberg M, Lee E, Brady J, Quon M, et al. SirT1 enhances survival of human osteoarthritic chondrocytes by repressing protein tyrosine phosphatase 1B and activating the insulin-like growth factor receptor pathway. Arthritis Rheum. 2010;62:1383-92 pubmed publisher
    The protein deacetylase SirT1 inhibits apoptosis in a variety of cell systems by distinct mechanisms, yet its role in chondrocyte death has not been explored...
  8. Kim J, Moon Y, Kwon K, Bae J, Wagle S, Yu T, et al. Expression of SIRT1 and DBC1 is associated with poor prognosis of soft tissue sarcomas. PLoS ONE. 2013;8:e74738 pubmed publisher
    Recently, the roles of SIRT1 and deleted in breast cancer 1 (DBC1) in human cancer have been extensively studied and it has been demonstrated that they are involved in many human carcinomas...
  9. Noh S, Baek H, Park H, Jang K, Moon W, Kang M, et al. Expression of SIRT1 and cortactin is associated with progression of non-small cell lung cancer. Pathol Res Pract. 2013;209:365-70 pubmed publisher
    ..Recent reports suggest that silent mating-type information regulation 2 homologue 1 (sirtuin1; SIRT1) enhances the function of cortactin and promotes cell migration...
  10. Zhang L, Huang Q, Fan X, Wu H, Yang J, Feng A. Clinicopathological significance of SIRT1 and p300/CBP expression in gastroesophageal junction (GEJ) cancer and the correlation with E-cadherin and MLH1. Pathol Res Pract. 2013;209:611-7 pubmed publisher
    b>SIRT1 and p300/CBP, which are considered to be essential histone deacetylases and acetyltransferases, are also considered to be relative to tumorigenesis because they modulate the expression of several tumor suppressor genes...
  11. Tegla C, Azimzadeh P, Andrian Albescu M, Martín A, Cudrici C, Trippe R, et al. SIRT1 is decreased during relapses in patients with multiple sclerosis. Exp Mol Pathol. 2014;96:139-48 pubmed publisher
    b>SIRT1 is a member of the histone deacetylase (HDAC) class III family of proteins and is an NAD-dependent histone and protein deacetylase...
  12. Zhang Z, Chung S, Xu Z, Xu Y. Oct4 maintains the pluripotency of human embryonic stem cells by inactivating p53 through Sirt1-mediated deacetylation. Stem Cells. 2014;32:157-65 pubmed publisher
    ..We further discovered that the silencing of Oct4 significantly reduces the expression of Sirt1, a deacetylase known to inhibit p53 activity and the differentiation of ESCs, leading to increased acetylation of ..
  13. Stenzinger A, Endris V, Klauschen F, Sinn B, Lorenz K, Warth A, et al. High SIRT1 expression is a negative prognosticator in pancreatic ductal adenocarcinoma. BMC Cancer. 2013;13:450 pubmed publisher
    Several lines of evidence indicate that Sirt1, a class III histone deacetylase (HDAC) is implicated in the initiation and progression of malignancies and thus gained attraction as druggable target...
  14. Nihal M, Ahmad N, Wood G. SIRT1 is upregulated in cutaneous T-cell lymphoma, and its inhibition induces growth arrest and apoptosis. Cell Cycle. 2014;13:632-40 pubmed publisher
    Silent information regulator type-1 (SIRT1) is the best-studied member of the Sirtuin (Sir2) family of nicotinamide dinucleotide (NAD)-dependent class III histone deacetylases (HDACs), but has not yet been explored in cutaneous T-cell ..
  15. Zhang L, Wang X, Chen P. MiR-204 down regulates SIRT1 and reverts SIRT1-induced epithelial-mesenchymal transition, anoikis resistance and invasion in gastric cancer cells. BMC Cancer. 2013;13:290 pubmed publisher
    Our previous studies showed that SIRT1 was over-expressed in gastric cancer specimens and related with lymph node metastasis...
  16. Sasca D, Hähnel P, Szybinski J, Khawaja K, Kriege O, Pante S, et al. SIRT1 prevents genotoxic stress-induced p53 activation in acute myeloid leukemia. Blood. 2014;124:121-33 pubmed publisher
    b>SIRT1 is an important regulator of cellular stress response and genomic integrity. Its role in tumorigenesis is controversial...
  17. Hubbard B, Loh C, Gomes A, Li J, Lu Q, Doyle T, et al. Carboxamide SIRT1 inhibitors block DBC1 binding via an acetylation-independent mechanism. Cell Cycle. 2013;12:2233-40 pubmed publisher
    b>SIRT1 is an NAD (+) -dependent deacetylase that counteracts multiple disease states associated with aging and may underlie some of the health benefits of calorie restriction...
  18. Choi G, Lee J, Ji J, Woo J, Kang N, Cho S, et al. Discovery of a potent small molecule SIRT1/2 inhibitor with anticancer effects. Int J Oncol. 2013;43:1205-11 pubmed publisher
    b>SIRT1 and SIRT2 are deacetylase enzymes that belong to the sirtuin family and are involved in tumorigenesis. In our screen for small molecules inhibiting SIRT1/2 toxoflavin was identified...
  19. Liu B, Zhang B, Guo R, Li S, Xu Y. Enhancement in efferocytosis of oxidized low-density lipoprotein-induced apoptotic RAW264.7 cells through Sirt1-mediated autophagy. Int J Mol Med. 2014;33:523-33 pubmed publisher
    ..Sirtuin1 (Sirt1), a member of the conserved sirtuin family and a key regulator in the progression of atherosclerosis exerts ..
  20. Kilic U, Gok O, Bacaksiz A, Izmirli M, Elibol Can B, Uysal O. SIRT1 gene polymorphisms affect the protein expression in cardiovascular diseases. PLoS ONE. 2014;9:e90428 pubmed publisher
    ..b>SIRT1 protein and its downstream pathways are critical for both normal homeostasis and protection from CVD-induced ..
  21. Woo S, Byun J, Kim Y, Park E, Joo H, Yun M, et al. SIRT1 suppresses cellular accumulation of ?-TrCP E3 ligase via protein degradation. Biochem Biophys Res Commun. 2013;441:831-7 pubmed publisher
    ..Here, we showed that SIRT1 suppresses ?-TrCP protein synthesis via post-translational degradation...
  22. Zheng H, Yang L, Peng L, Izumi V, Koomen J, Seto E, et al. hMOF acetylation of DBC1/CCAR2 prevents binding and inhibition of SirT1. Mol Cell Biol. 2013;33:4960-70 pubmed publisher
    The NAD(+)-dependent deacetylase SirT1 regulates gene silencing and genomic stability in response to nutrient deprivation and DNA damage...
  23. Yang Q, Wang B, Gao W, Huang S, Liu Z, Li W, et al. SIRT1 is downregulated in gastric cancer and leads to G1-phase arrest via NF-?B/Cyclin D1 signaling. Mol Cancer Res. 2013;11:1497-507 pubmed publisher
    Sirtuin 1 (SIRT1) is a class III histone/protein deacetylase, and its activation status has been well documented to have physiologic benefits in human health. However, the function of SIRT1 in cancer remains controversial...
  24. Zhang J, Hong D, Zhang C, Sun X, Wang Z, Shi Y, et al. Sirtuin 1 facilitates chemoresistance of pancreatic cancer cells by regulating adaptive response to chemotherapy-induced stress. Cancer Sci. 2014;105:445-54 pubmed publisher
    ..Our previous research showed that sirtuin 1 (SIRT1) was overexpressed in pancreatic cancer patients and deregulation of SIRT1 with RNAi could enhance ..
  25. Ou X, Lee M, Huang X, Messina Graham S, Broxmeyer H. SIRT1 positively regulates autophagy and mitochondria function in embryonic stem cells under oxidative stress. Stem Cells. 2014;32:1183-94 pubmed publisher
    b>SIRT1, an NAD-dependent deacetylase, plays a role in regulation of autophagy...
  26. Kitada M, Kume S, Takeda Watanabe A, Tsuda S, Kanasaki K, Koya D. Calorie restriction in overweight males ameliorates obesity-related metabolic alterations and cellular adaptations through anti-aging effects, possibly including AMPK and SIRT1 activation. Biochim Biophys Acta. 2013;1830:4820-7 pubmed publisher
    ..Several important signal transduction pathways including AMPK and SIRT1 are implicated in the regulation of physiological processes of CR...
  27. Kauppinen A, Suuronen T, Ojala J, Kaarniranta K, Salminen A. Antagonistic crosstalk between NF-?B and SIRT1 in the regulation of inflammation and metabolic disorders. Cell Signal. 2013;25:1939-48 pubmed publisher
    ..innate immunity and energy metabolism are connected together through an antagonistic crosstalk between NF-?B and SIRT1 signaling pathways...
  28. Zhang S, Liu L, Wang R, Tuo H, Guo Y, Yi L, et al. MiR-199a-5p promotes migration and tube formation of human cytomegalovirus-infected endothelial cells through downregulation of SIRT1 and eNOS. Arch Virol. 2013;158:2443-52 pubmed publisher
    ..We found that HCMV infection of endothelial cells (ECs) enhanced expression of miR-199a-5p and reduced the SIRT1 protein level at 24 h postinfection (hpi)...
  29. Liu X, Wang D, Zhao Y, Tu B, Zheng Z, Wang L, et al. Methyltransferase Set7/9 regulates p53 activity by interacting with Sirtuin 1 (SIRT1). Proc Natl Acad Sci U S A. 2011;108:1925-30 pubmed publisher
    Numerous studies indicate that Sirtuin 1 (SIRT1), a mammalian nicotinamide adenine dinucleotide (NAD(+))-dependent histone deacetylase (HDAC), plays a crucial role in p53-mediated stress responses by deacetylating p53...
  30. Cha E, Noh S, Kwon K, Kim C, Park B, Park H, et al. Expression of DBC1 and SIRT1 is associated with poor prognosis of gastric carcinoma. Clin Cancer Res. 2009;15:4453-9 pubmed publisher
    b>SIRT1 (silent mating-type information regulation 2 homologue 1) expression has been reported to predict poor survival in some cancers...
  31. Allison S, Jiang M, Milner J. Oncogenic viral protein HPV E7 up-regulates the SIRT1 longevity protein in human cervical cancer cells. Aging (Albany NY). 2009;1:316-27 pubmed
    ..We now present evidence that SIRT1, an aging-related NAD-dependent deacetylase, mediates HPV E7 survival function in SiHa cervical cancer cells...
  32. Menghini R, Casagrande V, Cardellini M, Martelli E, Terrinoni A, Amati F, et al. MicroRNA 217 modulates endothelial cell senescence via silent information regulator 1. Circulation. 2009;120:1524-32 pubmed publisher
    ..miR-217 regulates the expression of silent information regulator 1 (SirT1), a major regulator of longevity and metabolic disorders that is progressively reduced in multiple tissues during ..
  33. Moore R, Dai Y, Faller D. Sirtuin 1 (SIRT1) and steroid hormone receptor activity in cancer. J Endocrinol. 2012;213:37-48 pubmed publisher
    ..Furthermore, disruption of sirtuin activity may be an important step in the development of steroid hormone-refractory cancers. ..
  34. Shimoyama Y, Mitsuda Y, Tsuruta Y, Suzuki K, Hamajima N, Niwa T. SIRTUIN 1 gene polymorphisms are associated with cholesterol metabolism and coronary artery calcification in Japanese hemodialysis patients. J Ren Nutr. 2012;22:114-9 pubmed publisher
    Sirtuin 1 (SIRT1), a longevity gene, protects cells against oxidative and genotoxic stress...
  35. Bitterman K, Anderson R, Cohen H, Latorre Esteves M, Sinclair D. Inhibition of silencing and accelerated aging by nicotinamide, a putative negative regulator of yeast sir2 and human SIRT1. J Biol Chem. 2002;277:45099-107 pubmed
    ..A human homologue of Sir2, SIRT1, regulates the activity of the p53 tumor suppressor and inhibits apoptosis...
  36. Dickson B, Riddle N, Brooks J, Pasha T, Zhang P. Sirtuin 1 (SIRT1): a potential immunohistochemical marker and therapeutic target in soft tissue neoplasms with myoid differentiation. Hum Pathol. 2013;44:1125-30 pubmed publisher
    Sirtuin, silent mating-type information regulation 2 homolog Saccharomyces cerevisiae 1 (SIRT1), is a protein that has been implicated in multiple mammalian functions including cell aging, stress resistance, and differentiation...
  37. Canto C, Auwerx J. Caloric restriction, SIRT1 and longevity. Trends Endocrinol Metab. 2009;20:325-31 pubmed publisher
    ..Among the different mechanisms by which caloric restriction might act, Sir2/SIRT1 (Silent information regulator 2/Silent information regulator T1) has been the focus of much attention because of ..
  38. Yamamori T, Dericco J, Naqvi A, Hoffman T, Mattagajasingh I, Kasuno K, et al. SIRT1 deacetylates APE1 and regulates cellular base excision repair. Nucleic Acids Res. 2010;38:832-45 pubmed publisher
    ..Here, we show that APE1 is a target of the SIRTUIN1 (SIRT1) protein deacetylase. SIRT1 associates with APE1, and this association is increased with genotoxic stress...
  39. Choi H, Bae J, Jamiyandorj U, Noh S, Park H, Jang K, et al. Expression and role of SIRT1 in hepatocellular carcinoma. Oncol Rep. 2011;26:503-10 pubmed publisher
    Silent mating type information regulation 2 homolog 1 (SIRT1) is a multifaceted, nicotinamide adenine dinucleotide-dependent protein deacetylase with involvement in a wide variety of cellular processes ranging from cancer to aging...
  40. Nakahata Y, Kaluzova M, Grimaldi B, Sahar S, Hirayama J, Chen D, et al. The NAD+-dependent deacetylase SIRT1 modulates CLOCK-mediated chromatin remodeling and circadian control. Cell. 2008;134:329-40 pubmed publisher
    ..We show that the HDAC activity of the NAD(+)-dependent SIRT1 enzyme is regulated in a circadian manner, correlating with rhythmic acetylation of BMAL1 and H3 Lys9/Lys14 at ..
  41. Kabra N, Li Z, Chen L, Li B, Zhang X, Wang C, et al. SirT1 is an inhibitor of proliferation and tumor formation in colon cancer. J Biol Chem. 2009;284:18210-7 pubmed publisher
    The NAD-dependent deacetylase SirT1 regulates factors involved in stress response and cell survival and is a potential drug target of activators and inhibitors...
  42. Strum J, Johnson J, Ward J, Xie H, Feild J, Hester A, et al. MicroRNA 132 regulates nutritional stress-induced chemokine production through repression of SirT1. Mol Endocrinol. 2009;23:1876-84 pubmed publisher
    ..MiR-132 was shown to inhibit silent information regulator 1 (SirT1) expression through a miR-132 binding site in the 3'-untranslated region of SirT1...
  43. Wakeling L, Ions L, Ford D. Could Sirt1-mediated epigenetic effects contribute to the longevity response to dietary restriction and be mimicked by other dietary interventions?. Age (Dordr). 2009;31:327-41 pubmed publisher
    ..The pivotal role of the mammalian histone deacetylase (HDAC) Sirt1, and its homologue in other organisms, in mediating the effects of both DR and resveratrol on lifespan/ageing ..
  44. Yamakuchi M, Ferlito M, Lowenstein C. miR-34a repression of SIRT1 regulates apoptosis. Proc Natl Acad Sci U S A. 2008;105:13421-6 pubmed publisher
    ..We now show that the microRNA miR-34a regulates silent information regulator 1 (SIRT1) expression. MiR-34a inhibits SIRT1 expression through a miR-34a-binding site within the 3' UTR of SIRT1...
  45. Yuan Z, Zhang X, Sengupta N, Lane W, Seto E. SIRT1 regulates the function of the Nijmegen breakage syndrome protein. Mol Cell. 2007;27:149-62 pubmed
    ..Here, we report that NBS1 is an acetylated protein and that the acetylation level is tightly regulated by the SIRT1 deacetylase...
  46. Dai Y, Ngo D, Forman L, Qin D, Jacob J, Faller D. Sirtuin 1 is required for antagonist-induced transcriptional repression of androgen-responsive genes by the androgen receptor. Mol Endocrinol. 2007;21:1807-21 pubmed
    ..In this report, we demonstrate that sirtuin 1 (SIRT1), a nicotinamide adenosine dinucleotide-dependent histone deacetylase (HDAC) linked to the regulation of longevity,..
  47. Yamamoto H, Schoonjans K, Auwerx J. Sirtuin functions in health and disease. Mol Endocrinol. 2007;21:1745-55 pubmed
    ..The mammalian sirtuins SIRT1-SIRT7 are implicated in a variety of cellular functions ranging from gene silencing, over the control of the cell ..
  48. Inamori T, Goda T, Kasezawa N, Yamakawa Kobayashi K. The combined effects of genetic variation in the SIRT1 gene and dietary intake of n-3 and n-6 polyunsaturated fatty acids on serum LDL-C and HDL-C levels: a population based study. Lipids Health Dis. 2013;12:4 pubmed publisher
    ..Both SIRT1 and PUFAs can influence the expression of genes for nuclear receptors and transcription factors related to lipid ..
  49. Pagans S, Pedal A, North B, Kaehlcke K, Marshall B, Dorr A, et al. SIRT1 regulates HIV transcription via Tat deacetylation. PLoS Biol. 2005;3:e41 pubmed
    ..We report here that Tat is deacetylated by human sirtuin 1 (SIRT1), a nicotinamide adenine dinucleotide-dependent class III protein deacetylase in vitro and in vivo...
  50. Ghosh H, Spencer J, Ng B, McBurney M, Robbins P. Sirt1 interacts with transducin-like enhancer of split-1 to inhibit nuclear factor kappaB-mediated transcription. Biochem J. 2007;408:105-11 pubmed
    b>Sirt1 is an NAD+-dependent deacetylase that plays a role in cellular processes such as transcriptional regulation, stress response, longevity and apoptosis...
  51. Byles V, Chmilewski L, Wang J, Zhu L, Forman L, Faller D, et al. Aberrant cytoplasm localization and protein stability of SIRT1 is regulated by PI3K/IGF-1R signaling in human cancer cells. Int J Biol Sci. 2010;6:599-612 pubmed
    b>SIRT1, an NAD-dependent histone/protein deacetylase, has classically been thought of as a nuclear protein...
  52. Aquilano K, Vigilanza P, Baldelli S, Pagliei B, Rotilio G, Ciriolo M. Peroxisome proliferator-activated receptor gamma co-activator 1alpha (PGC-1alpha) and sirtuin 1 (SIRT1) reside in mitochondria: possible direct function in mitochondrial biogenesis. J Biol Chem. 2010;285:21590-9 pubmed publisher
    The transcriptional co-activator PGC-1alpha and the NAD(+)-dependent deacetylase SIRT1 are considered important inducers of mitochondrial biogenesis because in the nucleus they regulate transcription of nucleus-encoded mitochondrial ..
  53. Ma J, Li H, Chen X, Yang X, Wang Q, Wu M, et al. Expression patterns and potential roles of SIRT1 in human medulloblastoma cells in vivo and in vitro. Neuropathology. 2013;33:7-16 pubmed publisher
    ..Sirtuin 1 (SIRT1), a class III histone deacetylase (HDAC), regulates differentiation of neuronal stem cells but its status in ..
  54. Gao Z, Ye J. Inhibition of transcriptional activity of c-JUN by SIRT1. Biochem Biophys Res Commun. 2008;376:793-6 pubmed publisher
    ..b>SIRT1 (Sirtuin 1) is a histone deacetylase that controls gene transcription through modification of chromatin structure...
  55. Alvarez Y, Rodriguez M, Municio C, Hugo E, Alonso S, Ibarrola N, et al. Sirtuin 1 is a key regulator of the interleukin-12 p70/interleukin-23 balance in human dendritic cells. J Biol Chem. 2012;287:35689-701 pubmed publisher
    ..Zymosan produced the location of sirtuin 1 (SIRT1) to the nucleus, enhanced its association with the il12a promoter, increased the nuclear concentration of the ..
  56. Byles V, Zhu L, Lovaas J, Chmilewski L, Wang J, Faller D, et al. SIRT1 induces EMT by cooperating with EMT transcription factors and enhances prostate cancer cell migration and metastasis. Oncogene. 2012;31:4619-29 pubmed publisher
    ..we propose a novel mechanism through which the nicotinamide adenine dinucleotide-dependent histone deacetylase SIRT1 regulates EMT in prostate cancer cells through cooperation with the EMT inducing transcription factor ZEB1...
  57. Nasrin N, Kaushik V, Fortier E, Wall D, Pearson K, De Cabo R, et al. JNK1 phosphorylates SIRT1 and promotes its enzymatic activity. PLoS ONE. 2009;4:e8414 pubmed publisher
    b>SIRT1 is a NAD-dependent deacetylase that regulates a variety of pathways including the stress protection pathway...
  58. Nakane K, Fujita Y, Terazawa R, Atsumi Y, Kato T, Nozawa Y, et al. Inhibition of cortactin and SIRT1 expression attenuates migration and invasion of prostate cancer DU145 cells. Int J Urol. 2012;19:71-9 pubmed publisher
  59. Orimo M, Minamino T, Miyauchi H, Tateno K, Okada S, Moriya J, et al. Protective role of SIRT1 in diabetic vascular dysfunction. Arterioscler Thromb Vasc Biol. 2009;29:889-94 pubmed publisher
    ..b>SIRT1, a mammalian homolog of Sir2, has been reported to downregulate p53 activity and thereby prolong the lifespan of ..
  60. Rajendrasozhan S, Yang S, Kinnula V, Rahman I. SIRT1, an antiinflammatory and antiaging protein, is decreased in lungs of patients with chronic obstructive pulmonary disease. Am J Respir Crit Care Med. 2008;177:861-70 pubmed publisher
    ..Human sirtuin (SIRT1), an antiaging and antiinflammatory protein, is a metabolic NAD(+)-dependent protein/histone deacetylase that ..
  61. Das C, Lucia M, Hansen K, Tyler J. CBP/p300-mediated acetylation of histone H3 on lysine 56. Nature. 2009;459:113-7 pubmed publisher
    ..known as Nejire) in flies and CBP and p300 (Ep300) in humans acetylate H3K56, whereas Drosophila Sir2 and human SIRT1 and SIRT2 deacetylate H3K56ac...
  62. Zhang W, Bai X, Chen X. SIRT1 variants are associated with aging in a healthy Han Chinese population. Clin Chim Acta. 2010;411:1679-83 pubmed publisher
    Aging is influenced by diverse environmental and genetic risk factors. The SIRT1 (silent information regulator 1) gene has been shown to regulate lifespan and aging in previous studies...
  63. Li Z, Chen L, Kabra N, Wang C, Fang J, Chen J. Inhibition of SUV39H1 methyltransferase activity by DBC1. J Biol Chem. 2009;284:10361-6 pubmed publisher
    ..SUV39H1 forms a complex with SirT1, and its activity is stimulated by SirT1 binding...
  64. Lai C, Lin P, Lin S, Hsu C, Lin H, Hu M, et al. Altered expression of SIRT gene family in head and neck squamous cell carcinoma. Tumour Biol. 2013;34:1847-54 pubmed publisher
    ..Currently, seven human sirtuin (SIRT1-7) genes have been identified, but the roles of SIRT genes in HNSCC are still uncertain...
  65. Nakamaru Y, Vuppusetty C, Wada H, Milne J, Ito M, Rossios C, et al. A protein deacetylase SIRT1 is a negative regulator of metalloproteinase-9. FASEB J. 2009;23:2810-9 pubmed publisher
    ..increase of MMP9 expression, and here we show that oxidative stress-dependent reduction of a protein deacetylase, SIRT1, known as a putative antiaging enzyme, causes elevation of MMP9 expression...
  66. O Hagan H, Wang W, Sen S, DeStefano Shields C, Lee S, Zhang Y, et al. Oxidative damage targets complexes containing DNA methyltransferases, SIRT1, and polycomb members to promoter CpG Islands. Cancer Cell. 2011;20:606-19 pubmed publisher
    ..Thus, oxidative damage induces formation and relocalization of a silencing complex that may explain cancer-specific aberrant DNA methylation and transcriptional silencing. ..
  67. Kriegl L, Vieth M, Kirchner T, Menssen A. Up-regulation of c-MYC and SIRT1 expression correlates with malignant transformation in the serrated route to colorectal cancer. Oncotarget. 2012;3:1182-93 pubmed
    ..Here, we investigate the expression of the c-MYC oncogene and the SIRT1 protein deacetylase by immunohistochemical staining in subgroups of colorectal serrated lesions that were ..