SERPINB3

Summary

Gene Symbol: SERPINB3
Description: serpin family B member 3
Alias: HsT1196, SCC, SCCA-1, SCCA-PD, SCCA1, SSCA1, T4-A, serpin B3, protein T4-A, serine (or cysteine) proteinase inhibitor, clade B (ovalbumin), member 3, serpin peptidase inhibitor, clade B (ovalbumin), member 3, squamous cell carcinoma antigen 1
Species: human
Products:     SERPINB3

Top Publications

  1. Cataltepe S, Gornstein E, Schick C, Kamachi Y, Chatson K, Fries J, et al. Co-expression of the squamous cell carcinoma antigens 1 and 2 in normal adult human tissues and squamous cell carcinomas. J Histochem Cytochem. 2000;48:113-22 pubmed
    ..Recent molecular studies show that the SCCA is transcribed by two almost identical tandemly arrayed genes, SCCA1 and SCCA2. These genes are members of the high molecular weight serine proteinase inhibitor (serpin) superfamily...
  2. Mroczko B, Kozłowski M, Groblewska M, Łukaszewicz M, Niklinski J, Jelski W, et al. The diagnostic value of the measurement of matrix metalloproteinase 9 (MMP-9), squamous cell cancer antigen (SCC) and carcinoembryonic antigen (CEA) in the sera of esophageal cancer patients. Clin Chim Acta. 2008;389:61-6 pubmed
    ..We assayed serum levels of MMP-9 and classical tumor markers (SCC-Ag and CEA). We defined the prognostic value and diagnostic criteria for the measurands...
  3. Lim W, Kim H, Jeong W, Ahn S, Kim J, Kim Y, et al. SERPINB3 in the chicken model of ovarian cancer: a prognostic factor for platinum resistance and survival in patients with epithelial ovarian cancer. PLoS ONE. 2012;7:e49869 pubmed publisher
    ..Of these, squamous cell carcinoma antigen 1 (SCCA1), also known as a SERPINB3, was first identified in squamous cell carcinoma tissue from the ..
  4. Suminami Y, Kishi F, Sekiguchi K, Kato H. Squamous cell carcinoma antigen is a new member of the serine protease inhibitors. Biochem Biophys Res Commun. 1991;181:51-8 pubmed
    We have cloned cDNA of squamous cell carcinoma antigen. Sequence analysis of the complete 1711 basepairs SCC antigen cDNA revealed that it coded 390 amino acids and no typical signal sequence in the NH2-terminus...
  5. Mino N, Iio A, Hamamoto K. Availability of tumor-antigen 4 as a marker of squamous cell carcinoma of the lung and other organs. Cancer. 1988;62:730-4 pubmed
    The serum level of tumor-antigen 4 (TA-4) was measured in 401 patients with squamous cell carcinoma (SCC) of various organs (76 lung, 82 esophagus, and 234 head and neck). The mean serum level of TA-4 in patients with lung SCC was 3...
  6. Masumoto K, Sakata Y, Arima K, Nakao I, Izuhara K. Inhibitory mechanism of a cross-class serpin, the squamous cell carcinoma antigen 1. J Biol Chem. 2003;278:45296-304 pubmed
    ..Although SCCA2 inhibits serine proteinases such as cathepsin G and mast cell chymase, SCCA1 targets cysteine proteinases such as cathepsin S, K, L, and papain. SCCA1 is therefore called a cross-class serpin...
  7. Pontisso P, Calabrese F, Benvegnu L, Lise M, Belluco C, Ruvoletto M, et al. Overexpression of squamous cell carcinoma antigen variants in hepatocellular carcinoma. Br J Cancer. 2004;90:833-7 pubmed
    ..From sequence alignment, a novel SCCA1 variant (G(351) to A) was identified in five cases, while SCCA1 was revealed in six cases and SCCA2 in three cases...
  8. Katagiri C, Nakanishi J, Kadoya K, Hibino T. Serpin squamous cell carcinoma antigen inhibits UV-induced apoptosis via suppression of c-JUN NH2-terminal kinase. J Cell Biol. 2006;172:983-90 pubmed
    ..We demonstrate that up-regulation of squamous cell carcinoma antigen-1 (SCCA1) suppresses c-Jun NH2-terminal kinase-1 (JNK1) and thus blocks UV-induced keratinocyte apoptosis...
  9. Vidalino L, Doria A, Quarta S, Zen M, Gatta A, Pontisso P. SERPINB3, apoptosis and autoimmunity. Autoimmun Rev. 2009;9:108-12 pubmed publisher
    b>SERPINB3 (Squamous Cell Carcinoma Antigen, SCCA1) is a member of the ov-serpins, a serine protease inhibitors family expressed in many cell types including normal epithelium, leukocytes, tumors of epithelial origin and primary liver ..

More Information

Publications113 found, 100 shown here

  1. Turato C, Calabrese F, Biasiolo A, Quarta S, Ruvoletto M, Tono N, et al. SERPINB3 modulates TGF-beta expression in chronic liver disease. Lab Invest. 2010;90:1016-23 pubmed publisher
    ..TGF-beta1 and extent of fibrosis were correlated recently to the serpin SERPINB3 in idiopathic pulmonary fibrosis, a chronic disease recalling liver cirrhosis...
  2. Quarta S, Vidalino L, Turato C, Ruvoletto M, Calabrese F, Valente M, et al. SERPINB3 induces epithelial-mesenchymal transition. J Pathol. 2010;221:343-56 pubmed publisher
    ..b>SERPINB3 is a serine protease inhibitor, physiologically found in normal squamous epithelium but over-expressed in ..
  3. Catanzaro J, Guerriero J, Liu J, Ullman E, Sheshadri N, Chen J, et al. Elevated expression of squamous cell carcinoma antigen (SCCA) is associated with human breast carcinoma. PLoS ONE. 2011;6:e19096 pubmed publisher
    ..Elevated expression of SCCA has been used as a biomarker for aggressive squamous cell carcinoma (SCC) in cancers of the cervix, lung, head and neck, and liver...
  4. Biasiolo A, Tono N, Ruvoletto M, Quarta S, Turato C, Villano G, et al. IgM-linked SerpinB3 and SerpinB4 in sera of patients with chronic liver disease. PLoS ONE. 2012;7:e40658 pubmed publisher
    ..Recent findings have demonstrated that Squamous cell carcinoma antigen 1 (SCCA1) and 2 (SCCA2) isoforms, now classified as serpinB3 and serpinB4, are over-expressed in HCC, ..
  5. Vidalino L, Doria A, Quarta S, Crescenzi M, Ruvoletto M, Frezzato F, et al. SERPINB3 expression on B-cell surface in autoimmune diseases and hepatitis C virus-related chronic liver infection. Exp Biol Med (Maywood). 2012;237:793-802 pubmed publisher
    b>SERPINB3 is a serine protease inhibitor with pleiotropic functions. It is involved in several physiological and pathological processes, where it appears to exert antiapoptotic effects...
  6. Schneider S, Schick C, Fish K, Miller E, Pena J, Treter S, et al. A serine proteinase inhibitor locus at 18q21.3 contains a tandem duplication of the human squamous cell carcinoma antigen gene. Proc Natl Acad Sci U S A. 1995;92:3147-51 pubmed
    ..3. The genomic structure of the two genes, SCCA1 and SCCA2, was highly conserved...
  7. Schick C, Pemberton P, Shi G, Kamachi Y, Cataltepe S, Bartuski A, et al. Cross-class inhibition of the cysteine proteinases cathepsins K, L, and S by the serpin squamous cell carcinoma antigen 1: a kinetic analysis. Biochemistry. 1998;37:5258-66 pubmed
    ..1997) J. Biol. Chem. 272, 1849-1855]. We now show that, unlike SCCA2, SCCA1 lacks inhibitory activity against any of the more common types of serine proteinases but is a potent cross-class ..
  8. Shimada H, Nabeya Y, Okazumi S, Matsubara H, Shiratori T, Gunji Y, et al. Prediction of survival with squamous cell carcinoma antigen in patients with resectable esophageal squamous cell carcinoma. Surgery. 2003;133:486-94 pubmed
    Increased preoperative serum squamous cell carcinoma antigen (SCC-Ag) concentrations have been found to be associated with advanced stage and poor prognosis in lung and cervical cancers...
  9. Ray R, Choi M, Zhang Z, Silverman G, Askew D, Mukherjee A. Uteroglobin suppresses SCCA gene expression associated with allergic asthma. J Biol Chem. 2005;280:9761-4 pubmed
    ..bronchial epithelial cells with IL-4 or IL-13 stimulates phosphorylation of STAT-1 and STAT-6 leading to SCCA-1 (SERPINB3) and SCCA-2 (SERPINB4) gene expression...
  10. Yoon S, Shin K, Kim J, Seo S, Park S, Moon S, et al. Use of serum squamous cell carcinoma antigen for follow-up monitoring of cervical cancer patients who were treated by concurrent chemoradiotherapy. Radiat Oncol. 2010;5:78 pubmed publisher
    To investigate the significance of monitoring the levels of the serum squamous cell carcinoma antigen (SCC-Ag) for the detection of recurrent disease in patients with cervical cancer treated by concurrent chemoradiotherapy...
  11. Turato C, Buendia M, Fabre M, Redon M, Branchereau S, Quarta S, et al. Over-expression of SERPINB3 in hepatoblastoma: a possible insight into the genesis of this tumour?. Eur J Cancer. 2012;48:1219-26 pubmed publisher
    The serpin SERPINB3 (SB3) found over-expressed in human hepatocellular carcinoma and in regenerating liver in mice has been shown to induce apoptosis resistance, epithelial-to-mesenchymal transition and increasing cellular invasion...
  12. Trapphoff T, Heiligentag M, Dankert D, Demond H, Deutsch D, Fröhlich T, et al. Postovulatory aging affects dynamics of mRNA, expression and localization of maternal effect proteins, spindle integrity and pericentromeric proteins in mouse oocytes. Hum Reprod. 2016;31:133-49 pubmed publisher
    ..MSY2 was enriched in the subcortical RNP domain (SCRD) and in the spindle chromosome complex (SCC) in a distinct pattern, right and left to the chromosomes...
  13. Paiva P, Lockhart M, Girling J, Olshansky M, Woodrow N, Marino J, et al. Identification of genes differentially expressed in menstrual breakdown and repair. Mol Hum Reprod. 2016;22:898-912 pubmed
    ..including lipopolysaccharide binding protein, serpin peptidase inhibitor, clade B (ovalbumin), member 3 (SERPINB3) and -4 (SERPINB4), interleukin-17C (IL17C), V-set domain containing T-cell activation inhibitor 1 (VTCN1), ..
  14. Verma R, Krishna A. Effect of Letrozole, a selective aromatase inhibitor, on testicular activities in adult mice: Both in vivo and in vitro study. Gen Comp Endocrinol. 2017;241:57-68 pubmed publisher
    ..lymphoma factor-2; Bcl2), apoptotic (cysteine-aspartic proteases; caspase-3), steroidogenic (side chain cleavage; SCC, 3β-hydroxy steroid dehydrogenase enzyme; 3β HSD, steroidogenic acute regulatory protein; StAR, aromatase and ..
  15. Sannigrahi M, Sharma R, Singh V, Panda N, Rattan V, Khullar M. DNA methylation regulated microRNAs in HPV-16-induced head and neck squamous cell carcinoma (HNSCC). Mol Cell Biochem. 2018;: pubmed publisher
    ..HPV-negative cell line (UPCI:SCC-116) and HPV-16 +ve cell line (UPCI:SCC-090) were treated with methylation inhibitor (5-aza-2'-deoxycytidine, AZA) ..
  16. De Boyer Des Roches A, Faure M, Lussert A, Herry V, Rainard P, Durand D, et al. Behavioral and patho-physiological response as possible signs of pain in dairy cows during Escherichia coli mastitis: A pilot study. J Dairy Sci. 2017;100:8385-8397 pubmed publisher
    ..Evolution of the disease was assessed using bacteriological growth and somatic cell counts (SCC)...
  17. Martens M, Seebode C, Lehmann J, Emmert S. Photocarcinogenesis and Skin Cancer Prevention Strategies: An Update. Anticancer Res. 2018;38:1153-1158 pubmed
    ..and therefore contributes to the development of skin cancer entities such as squamous cell carcinoma (SCC), basal cell carcinoma (BCC), and melanoma...
  18. Xie J, Jiang Y, Jiang Y, Li C, Lim M, An O, et al. Super-Enhancer-Driven Long Non-Coding RNA LINC01503, Regulated by TP63, Is Over-Expressed and Oncogenic in Squamous Cell Carcinoma. Gastroenterology. 2018;154:2137-2151.e1 pubmed publisher
    ..We aimed to identify squamous cell carcinoma (SCC)-specific lncRNAs and investigate mechanisms that control their expression and function...
  19. Domingues J, Wajima C, Cesconetto P, Parisotto E, Winkelmann Duarte E, Santos K, et al. Experimentally-induced maternal hypothyroidism alters enzyme activities and the sensorimotor cortex of the offspring rats. Mol Cell Endocrinol. 2018;478:62-76 pubmed publisher
    ..Morphological and structural characterization of the sensorimotor cerebral cortex (SCC) showed unaltered thickness of the SCC...
  20. Matrka M, Cimperman K, Haas S, Guasch G, Ehrman L, Waclaw R, et al. Dek overexpression in murine epithelia increases overt esophageal squamous cell carcinoma incidence. PLoS Genet. 2018;14:e1007227 pubmed publisher
    ..Here we report that expression of the human DEK oncogene is strongly upregulated in esophageal SCC based on data in the cancer genome atlas (TCGA)...
  21. Yokoyama A, Mizukami T, Yokoyama T. Genetic polymorphisms of alcohol dehydrogense-1B and aldehyde dehydrogenase-2, alcohol flushing, mean corpuscular volume, and aerodigestive tract neoplasia in Japanese drinkers. Adv Exp Med Biol. 2015;815:265-79 pubmed publisher
    ..screening of 6,014 Japanese alcoholics yielded high detection rates of esophageal squamous cell carcinoma (SCC; 4.1%) and head and neck SCC (1.0%)...
  22. Stratigos A, Garbe C, Lebbe C, Malvehy J, del Marmol V, Pehamberger H, et al. Diagnosis and treatment of invasive squamous cell carcinoma of the skin: European consensus-based interdisciplinary guideline. Eur J Cancer. 2015;51:1989-2007 pubmed publisher
    ..The first line treatment of cutaneous SCC is complete surgical excision with histopathological control of excision margins...
  23. Solov eva N, Timoshenko O, Kugaevskaia E, Andreeva I, Zavalishina L. [Key enzymes of degradation and angiogenesis as a factors of tumor progression in squamous cell carcinoma of the cervix]. Bioorg Khim. 2014;40:743-51 pubmed
    ..particularity expression of key enzymes of destruction and angiogenesis in squamous cell carcinoma of the cervix (SCC)...
  24. Cao X, Zhang L, Feng G, Yang J, Wang R, Li J, et al. Preoperative Cyfra21-1 and SCC-Ag serum titers predict survival in patients with stage II esophageal squamous cell carcinoma. J Transl Med. 2012;10:197 pubmed publisher
    ..of preoperative serum level of cytokeratin 19 fragments (Cyfra21-1) and squamous cell carcinoma antigen (SCC-Ag) after complete resection in patients with stage II esophageal squamous cell carcinoma (ESCC)...
  25. Rana M, Kanatas A, Herzberg P, Gellrich N, Rana M. Relevance of psychosocial factors to quality of life in oral cancer and oral lichen planus: a prospective comparative study. Br J Oral Maxillofac Surg. 2015;53:621-6 pubmed publisher
    We can improve our understanding of how patients cope with oral squamous cell carcinoma (SCC) by making a comparison with their processes of coping and those used in other conditions...
  26. Overmiller A, McGuinn K, Roberts B, Cooper F, Brennan Crispi D, Deguchi T, et al. c-Src/Cav1-dependent activation of the EGFR by Dsg2. Oncotarget. 2016;7:37536-37555 pubmed publisher
    ..Functionally, overexpression of Dsg2 in human SCC A431 cells enhances EGFR activation and increases cell proliferation and migration through a c-Src and EGFR ..
  27. Tripathi M, Swanson P. Rare tumors of esophageal squamous mucosa. Ann N Y Acad Sci. 2016;1381:122-132 pubmed publisher
    ..of increasing incidence of esophageal adenocarcinoma in the last few decades, esophageal squamous cell carcinoma (SCC) still remains the dominant subtype of esophageal cancer worldwide...
  28. Ishihara R, Matsuura N, Hanaoka N, Yamamoto S, Akasaka T, Takeuchi Y, et al. Endoscopic imaging modalities for diagnosing invasion depth of superficial esophageal squamous cell carcinoma: a systematic review and meta-analysis. BMC Gastroenterol. 2017;17:24 pubmed publisher
    ..utilities of different endoscopic modalities for diagnosing invasion depth of esophageal squamous cell carcinoma (SCC)...
  29. Elsamra S, Poch M. Robotic inguinal lymphadenectomy for penile cancer: the why, how, and what. Transl Androl Urol. 2017;6:826-832 pubmed publisher
    Squamous cell carcinoma of the penis (SCC-P) demonstrates a reliable pattern of spread to the lymph nodes of the groin...
  30. Wakasaki T, Kiyohara H, Omori H, Nishi K, Taguchi K, Rikimaru F, et al. Massive internal jugular vein tumor thrombus derived from squamous cell carcinoma of the head and neck: two case reports. Oral Maxillofac Surg. 2017;21:69-74 pubmed publisher
    ..In the present study, we describe two cases of IJV tumor thrombosis originated from squamous cell carcinoma (SCC), which is the first case report...
  31. Matsui A. Screening for biliary atresia. Pediatr Surg Int. 2017;33:1305-1313 pubmed publisher
    ..Published analyses in English and Japanese indicate that screening by SCC and DB/CB is potentially feasible. Screening with SCC has been implemented in Tochigi Prefecture, Japan, since 1994...
  32. Barquet Muñoz S, Cruz Rodríguez E, Cantú de León D, Isla Ortiz D, Montalvo Esquivel G, Herrera Montalvo L, et al. Histology as Prognostic Factor in Early-Stage Cervical Carcinoma. Experience in a Third-Level Institution. Rev Invest Clin. 2017;69:286-292 pubmed
    ..The most common histopathological type is squamous cell carcinoma (SCC), followed by adenocarcinoma (AC) and adenosquamous carcinoma (ASC)...
  33. Duim B, Verstappen K, Kalupahana R, Ranathunga L, Fluit A, Wagenaar J. Methicillin-resistant Staphylococcus pseudintermedius among dogs in the description of novel SCCmec variants. Vet Microbiol. 2018;213:136-141 pubmed publisher
    ..Six MRSP CC45 isolates contained a pseudo-SCC element ?SCCmec57395...
  34. Detilleux J. Tolerance to bovine clinical mastitis: Total, direct, and indirect milk losses. J Dairy Sci. 2018;101:3334-3343 pubmed publisher
    ..Indirect losses, linked to indirect tolerance, are mediated by the increase in milk somatic cell count (SCC) in response to bacterial infection...
  35. Woldetsadik M, Goggin K, Staggs V, Wanyenze R, Beyeza Kashesya J, Mindry D, et al. Safer Conception Methods and Counseling: Psychometric Evaluation of New Measures of Attitudes and Beliefs Among HIV Clients and Providers. AIDS Behav. 2016;20:1370-81 pubmed publisher
    ..provider scales measuring constructs related to safer conception methods (SCM) and safer conception counselling (SCC). Several forms of validity (i.e...
  36. Damm M, Jensen T, Mahmood B, Lundh M, Poulsen S, Bindslev N, et al. Acetylcholine-related proteins in non-neoplastic appearing colonic mucosa from patients with colorectal neoplasia. Mol Carcinog. 2017;56:2223-2233 pubmed publisher
    ..Functional responses to ACh, measured as electrogenic transepithelial short circuit current (SCC), were recorded using the Ussing chamber technique...
  37. Hazkani I, Rabinovics N, Limon D, Silvern D, Koren S, Hadar T, et al. Brachytherapy for radiotherapy-resistant head and neck cancer: A review of a single center experience. Laryngoscope. 2016;126:2246-51 pubmed publisher
    ..Of those 13 patients, 10 patients were diagnosed with squamous cell carcinoma (SCC) of the oral cavity, two patients with SCC of the nasal mucosa, and one patient with eccrine duct carcinoma...
  38. Rapp J, Kiss E, Meggyes M, Szabó Meleg E, Feller D, Smuk G, et al. Increased Wnt5a in squamous cell lung carcinoma inhibits endothelial cell motility. BMC Cancer. 2016;16:915 pubmed
    ..two main subtypes of non-small-cell lung cancers (NSCLC) namely, adenocarcinoma (AC) and squamous cell carcinoma (SCC) respond differently to anti-angiogenic e.g...
  39. Gasmelseed N, Abudris D, Elhaj A, Eltayeb E, Elmadani A, Elhassan M, et al. Patterns of Esophageal Cancer in the National Cancer Institute at the University of Gezira, in Gezira State, Sudan, in 1999-2012. Asian Pac J Cancer Prev. 2015;16:6481-90 pubmed
    ..Squamous cell carcinoma (SCC) was the predominant EC tumor type (90%), and adenocarcinoma (ADC) was reported in 9.4% of the EC cases...
  40. Marioni G, Agostini M, Cappellesso R, Bedin C, Ottaviano G, Marchese Ragona R, et al. miR-19a and SOCS-1 expression in the differential diagnosis of laryngeal (glottic) verrucous squamous cell carcinoma. J Clin Pathol. 2016;69:415-21 pubmed publisher
    Laryngeal verrucous squamous cell carcinoma (VSCC) is a highly differentiated squamous cell carcinoma (SCC), the diagnosis of which can meet with many pitfalls: benign hyperplastic lesions and conventional SCC are the most important ..
  41. Ito T, Morita S, Shimeno N, Uehara K, Imai Y, Inokuma T. The prospect of endoscopic submucosal dissection for early anal canal squamous cell carcinoma. Clin J Gastroenterol. 2016;9:384-388 pubmed
    Squamous cell carcinoma (SCC) of the anal canal is seldom diagnosed at an early stage. Chemoradiation therapy is a standard in Europe and the United States, though in squamous cell carcinoma there is no evidence-based therapy...
  42. Fabbri A, Cossa M, Sonzogni A, Papotti M, Righi L, Gatti G, et al. Ki-67 labeling index of neuroendocrine tumors of the lung has a high level of correspondence between biopsy samples and surgical specimens when strict counting guidelines are applied. Virchows Arch. 2017;470:153-164 pubmed publisher
    ..A 20% cutoff distinguished TC and AC from LCNEC and SCC with 100% specificity and sensitivity, while mitoses and necrosis failed to a large extent...
  43. Moore F, Baldos U, Hertel T, Diaz D. New science of climate change impacts on agriculture implies higher social cost of carbon. Nat Commun. 2017;8:1607 pubmed publisher
    ..years, the scientific basis for damage functions in economic models used to calculate the social cost of carbon (SCC) is either undocumented, difficult to trace, or based on a small number of dated studies...
  44. Lyhne N, Johansen J, Kristensen C, Andersen E, Primdahl H, Andersen L, et al. Incidence of and survival after glottic squamous cell carcinoma in Denmark from 1971 to 2011-A report from the Danish Head and Neck Cancer Group. Eur J Cancer. 2016;59:46-56 pubmed publisher
    ..disease-specific mortality (DSM), and overall survival (OS) of patients with glottic squamous cell carcinomas (SCC) in Denmark from 1971-2011 in a national population-based cohort of consecutive patients...
  45. Thomas D, Thiagarajan P, Rai V, Reizes O, Lathia J, Egelhoff T. Increased cancer stem cell invasion is mediated by myosin IIB and nuclear translocation. Oncotarget. 2016;7:47586-47592 pubmed publisher
    ..We observed no difference between CSC and non-SCC in cellular migration rates on a 2D surface...
  46. Levine M, Chandrasekar P. Adverse effects of voriconazole: Over a decade of use. Clin Transplant. 2016;30:1377-1386 pubmed publisher
    ..Most concerning is the increased risk of cutaneous malignancies, primarily squamous cell carcinoma (SCC); this risk is duration dependent and the associated malignancies tend to be more aggressive and multifocal...
  47. López F, Williams M, Cardesa A, Hunt J, Strojan P, Rinaldo A, et al. How phenotype guides management of non-conventional squamous cell carcinomas of the larynx?. Eur Arch Otorhinolaryngol. 2017;274:2709-2726 pubmed publisher
    Although the majority of laryngeal malignancies are the conventional squamous cell carcinomas (SCC), a wide variety of malignant epithelial tumors can affect the larynx...
  48. Tagliabue E, Fargnoli M, Gandini S, Maisonneuve P, Liu F, Kayser M, et al. MC1R gene variants and non-melanoma skin cancer: a pooled-analysis from the M-SKIP project. Br J Cancer. 2015;113:354-63 pubmed publisher
    ..one MC1R variant had an increased risk of NMSC overall, basal cell carcinoma (BCC) and squamous cell carcinoma (SCC): SOR (95%CI) were 1.48 (1.24-1.76), 1.39 (1.15-1.69) and 1.61 (1.35-1.91), respectively...
  49. Manjunath A, Brenton T, Wylie S, Corbishley C, Watkin N. Topical Therapy for non-invasive penile cancer (Tis)-updated results and toxicity. Transl Androl Urol. 2017;6:803-808 pubmed publisher
    ..Ninety-five percent of cases of penile cancer are squamous cell carcinoma (SCC), which are staged using the TNM staging system...
  50. Van Batavia J, Yamany T, Molotkov A, Dan H, Mansukhani M, Batourina E, et al. Bladder cancers arise from distinct urothelial sub-populations. Nat Cell Biol. 2014;16:982-91, 1-5 pubmed publisher
    ..This heterogeneous set of lesions including urothelial carcinoma (Uca) and squamous cell carcinoma (SCC) arise from the urothelium, a stratified epithelium composed of K5-expressing basal cells, intermediate cells and ..
  51. Schonauer F, Di Martino A, Nele G, Santoro M, Dell Aversana Orabona G, Califano L. Submental flap as an alternative to microsurgical flap in intraoral post-oncological reconstruction in the elderly. Int J Surg. 2016;33 Suppl 1:S51-6 pubmed publisher
    Oral and oropharyngeal squamous cell carcinoma (Scc) occur most commonly in middle-aged and elderly individuals. Free flaps are commonly used for reconstruction of extensive tumor resection defects in the oral cavity...
  52. Ray J, Ranganathan K, Chattopadhyay A. Malignant transformation of oral submucous fibrosis: overview of histopathological aspects. Oral Surg Oral Med Oral Pathol Oral Radiol. 2016;122:200-9 pubmed publisher
    ..Malignant transformation of OSF to squamous cell carcinoma (SCC) has been estimated to be between 2% and 8%...
  53. Strom T, Caudell J, Harrison L. Management of BCC and SCC of the Head and Neck. Cancer Control. 2016;23:220-7 pubmed
    ..techniques used with RT for the management of cutaneous basal cell carcinoma (BCC) and squamous cell carcinoma (SCC) of the head and neck...
  54. Sakakibara A, Sakakibara S, Kusumoto J, Takeda D, Hasegawa T, Akashi M, et al. Upregulated Expression of Transient Receptor Potential Cation Channel Subfamily V Receptors in Mucosae of Patients with Oral Squamous Cell Carcinoma and Patients with a History of Alcohol Consumption or Smoking. PLoS ONE. 2017;12:e0169723 pubmed publisher
    ..Hence, we examined the relationship between oral squamous cell carcinoma (SCC) and TRPV1-4 expression. Oral SCC patients (n = 37) who underwent surgical resection were included in this study...
  55. Condas L, De Buck J, Nobrega D, Carson D, Roy J, Keefe G, et al. Distribution of non-aureus staphylococci species in udder quarters with low and high somatic cell count, and clinical mastitis. J Dairy Sci. 2017;100:5613-5627 pubmed publisher
    ..Overall, NAS intramammary infections (IMI) increase somatic cell count (SCC), with an effect categorized as mild, mostly causing subclinical or mild to moderate clinical mastitis...
  56. Mahmoud O, Sung K, Civantos F, Thomas G, Samuels M. Transoral robotic surgery for oropharyngeal squamous cell carcinoma in the era of human papillomavirus. Head Neck. 2017;: pubmed publisher
    ..TORS) ignited the debate between surgical and nonsurgical strategies on oropharyngeal squamous cell carcinoma (SCC) management; a question further complicated by human papillomavirus (HPV)...
  57. Languino L, Singh A, Prisco M, Inman G, Luginbuhl A, Curry J, et al. Exosome-mediated transfer from the tumor microenvironment increases TGF? signaling in squamous cell carcinoma. Am J Transl Res. 2016;8:2432-7 pubmed
    ..of function mutation in TGF? type II receptor (T?RII) is a frequent event in oral cavity squamous cell carcinoma (SCC)...
  58. Li H, Zheng H, Li L, Shen X, Zang W, Sun Y. The Effects of Matrix Metalloproteinase-9 on Dairy Goat Mastitis and Cell Survival of Goat Mammary Epithelial Cells. PLoS ONE. 2016;11:e0160989 pubmed publisher
    ..However, the relationship between MMP-9 and somatic cell count (SCC) in goat milk and the role of MMP-9 in the regulation of mastitis are still unknown...
  59. Kim S, Ryu Y, Kwon J, Choe M, Jung J, Cho J. Differential expression of cyclin D1, Ki?67, pRb, and p53 in psoriatic skin lesions and normal skin. Mol Med Rep. 2017;: pubmed publisher
    ..anti?p16INK4a, and anti?Ki?67 antibodies in normal skin, psoriatic epidermal tissue, and squamous cell carcinoma (SCC) tissue...
  60. Almadori G, Rigante M, Bussu F, Parrilla C, Gallus R, Barone Adesi L, et al. Impact of microvascular free flap reconstruction in oral cavity cancer: our experience in 130 cases. Acta Otorhinolaryngol Ital. 2015;35:386-93 pubmed publisher
    ..88.5% of patients were affected by SCC. There were 46 (35.4%) women and 84 (64.6%) men in the sample with a mean age of 58.5 years...
  61. Kubota H, Komarov D, Yasui H, Matsumoto S, Inanami O, Kirilyuk I, et al. Feasibility of in vivo three-dimensional T 2* mapping using dicarboxy-PROXYL and CW-EPR-based single-point imaging. MAGMA. 2017;30:291-298 pubmed publisher
    ..A clonogenic cell survival assay was performed with the 2H-DCP radical using squamous cell carcinoma (SCC VII) cells...
  62. Nakaminami H, Ito A, Sakanashi D, Suematsu H, Yamagishi Y, Mikamo H, et al. Genetic diversity of pvl-positive community-onset methicillin-resistant Staphylococcus aureus isolated at a university hospital in Japan. J Infect Chemother. 2017;23:856-858 pubmed publisher
    ..Panton-Valentine leukocidin gene (pvl)-positive sequence type (ST) 8-staphylococcal cassette chromosome (SCC) mec type IV (ST8-IV) as represented by the USA300 clone, is the most prevalent CA-MRSA in many countries...
  63. Corvo R, Margarino G, Sanguineti G, Geido E, Scala M, Mereu P, et al. Cell kinetics analysis in patients affected by squamous cell carcinoma of the head and neck treated with primary surgery and adjuvant radiotherapy. Tumori. 2000;86:53-8 pubmed
    The increasing complexity of management strategies for patients with head and neck squamous cell carcinoma (HN-SCC) calls for the investigation of new objective prognostic parameters to subdivide patients according to the tumor's ..
  64. Eimpunth S, Goldenberg A, Hamman M, Oganesyan G, Lee R, Hunnangkul S, et al. Squamous Cell Carcinoma In Situ Upstaged to Invasive Squamous Cell Carcinoma: A 5-Year, Single Institution Retrospective Review. Dermatol Surg. 2017;43:698-703 pubmed publisher
    ..be able to accurately distinguish squamous cell carcinoma in situ (SCCIS) from invasive squamous cell carcinoma (SCC)...
  65. Kashofer K, Regauer S. Analysis of full coding sequence of the TP53 gene in invasive vulvar cancers: Implications for therapy. Gynecol Oncol. 2017;146:314-318 pubmed publisher
    ..TP53 gene mutations and HPV status in 72 consecutively diagnosed primary invasive vulvar squamous cell carcinomas (SCC) during the past 5years...
  66. Cirillo N, Morgan D, Pedicillo M, Celentano A, Lo Muzio L, McCullough M, et al. Characterisation of the cancer-associated glucocorticoid system: key role of 11?-hydroxysteroid dehydrogenase type 2. Br J Cancer. 2017;117:984-993 pubmed publisher
    ..The presence of a functioning glucocorticoid system was assessed in human skin squamous cell carcinoma (SCC) and melanoma and further, in 16 epithelial cell lines from 8 different tissue types using ELISA, western blotting ..
  67. Svensson E, Karlsson M. Modelling of mycobacterial load reveals bedaquiline's exposure-response relationship in patients with drug-resistant TB. J Antimicrob Chemother. 2017;72:3398-3405 pubmed publisher
    Bedaquiline has been shown to reduce time to sputum culture conversion (SCC) and increase cure rates in patients with drug-resistant TB, but the influence of drug exposure remains uncharacterized...
  68. Qiao B, Cai J, King Yin Lam A, He B. MicroRNA-542-3p inhibits oral squamous cell carcinoma progression by inhibiting ILK/TGF-?1/Smad2/3 signaling. Oncotarget. 2017;8:70761-70776 pubmed publisher
    ..This was accompanied by high ILK expression and poor survival. Dual luciferase reporter assays of SCC-9 cells showed that miR-542-3p inhibited ILK gene expression by binding to its 3'UTR at 233-240 bp...
  69. Krasnov G, Puzanov G, Kudryavtseva A, Dmitriev A, Beniaminov A, Kondratieva T, et al. [Differential expression of an ensemble of the key genes involved in cell-cycle regulation in lung cancer]. Mol Biol (Mosk). 2017;51:849-856 pubmed publisher
    ..of specific molecular markers for the differential diagnosis of adenocarcinoma (ADC) and squamous cell lung cancer (SCC), as well as new targets for therapy...
  70. Mossad N, Mahmoud E, Osman E, Mahmoud S, Shousha H. Evaluation of squamous cell carcinoma antigen-immunoglobulin M complex (SCCA-IGM) and alpha-L-fucosidase (AFU) as novel diagnostic biomarkers for hepatocellular carcinoma. Tumour Biol. 2014;35:11559-64 pubmed publisher
    ..The significant difference between SCCA-IgM and AFU levels among HCC and cirrhotic patients suggests their use as potential diagnostic tools and allows identifying a new group of HCC patients even in the absence of elevated AFP. ..
  71. Tu M, Huang W, Hsu Y, Lo C, Deng J, Huang C. Comparison of neuropsychiatric symptoms and diffusion tensor imaging correlates among patients with subcortical ischemic vascular disease and Alzheimer's disease. BMC Neurol. 2017;17:144 pubmed publisher
    ..DTI parameters [fractional anisotropy (FA) and mean diffusivity (MD)] within the genu, body (BCC), and splenium (SCC) of the CC and other major fibers were assessed...
  72. Kuklinski L, Li S, Karagas M, Weng W, Kwong B. Effect of voriconazole on risk of nonmelanoma skin cancer after hematopoietic cell transplantation. J Am Acad Dermatol. 2017;77:706-712 pubmed publisher
    Voriconazole has previously been associated with increased risk for cutaneous squamous cell carcinoma (SCC) in solid organ transplant recipients. Less is known about the risk in patients after hematopoietic cell transplantation (HCT)...
  73. Tiefenböck Hansson K, Haapaniemi A, Farnebo L, Palmgren B, Tarkkanen J, Farnebo M, et al. WRAP53β, survivin and p16INK4a expression as potential predictors of radiotherapy/chemoradiotherapy response in T2N0-T3N0 glottic laryngeal cancer. Oncol Rep. 2017;38:2062-2068 pubmed publisher
    The current treatment recommendation for T2-3N0M0 glottic squamous cell carcinoma (SCC) in the Nordic countries comprises of radiotherapy (RT) and chemoradiotherapy (CRT)...
  74. Tan D, Chong F, Leong H, Toh S, Lau D, Kwang X, et al. Long noncoding RNA EGFR-AS1 mediates epidermal growth factor receptor addiction and modulates treatment response in squamous cell carcinoma. Nat Med. 2017;23:1167-1175 pubmed publisher
    ..2361G>A (encoding p.Gln787Gln), in two patients with head and neck SCC (HNSCC) who were exceptional responders to gefitinib, and we showed in patient-derived cultures that the A/A ..
  75. Xiang T, Bai J, She C, Yu D, Zhou X, Zhao T. Bromodomain protein BRD4 promotes cell proliferation in skin squamous cell carcinoma. Cell Signal. 2018;42:106-113 pubmed publisher
    ..the expression and biological functions of bromodomain-containing protein 4 (BRD4) in skin squamous cell carcinoma (SCC) cells...
  76. Nobeyama Y, Watanabe Y, Nakagawa H. Silencing of G0/G1 switch gene 2 in cutaneous squamous cell carcinoma. PLoS ONE. 2017;12:e0187047 pubmed publisher
    ..The aim of this study is to elucidate the methylation status of the CGI located in the 5' region of G0S2 (hereinafter called 5' G0S2 CGI) in cutaneous squamous cell carcinoma (SCC).
  77. Sheil F, Donohoe C, King S, O Toole D, Cunningham M, Cuffe S, et al. Outcomes for Esophageal Squamous Cell Carcinoma Treated with Curative Intent in a Western Cohort: Should Multimodal Therapy Be the Gold Standard?. World J Surg. 2018;42:1485-1495 pubmed publisher
    The standard of care for treatment of oesophageal squamous cell carcinoma (SCC) continues to evolve...
  78. Varghese V, Shukla V, Kabekkodu S, Pandey D, Satyamoorthy K. DNA methylation regulated microRNAs in human cervical cancer. Mol Carcinog. 2017;: pubmed publisher
    ..on Normal Cervical Epithelium (NCE), Cervical Intraepithelial Neoplasia (CIN I-III) and Squamous Cell Carcinoma (SCC) tissues to identify differentially methylated miRNAs followed by validation by bisulfite sequencing...
  79. Hamada M, Kameyama H, Iwai S, Yura Y. Induction of autophagy by sphingosine kinase 1 inhibitor PF-543 in head and neck squamous cell carcinoma cells. Cell Death Discov. 2017;3:17047 pubmed publisher
    Sphingosine kinase 1 (SphK1) overexpressed in head and neck squamous cell carcinoma (SCC) regulates tumor growth. The effects of PF-543, a specific SphK1 inhibitor, on human SCC cells were examined...
  80. Gu W, Zhu Y, Ye D. Beyond chemotherapy for advanced disease-the role of EGFR and PD-1 inhibitors. Transl Androl Urol. 2017;6:848-854 pubmed publisher
    Penile squamous cell carcinoma (SCC) is a rare malignancy with limited treatment options when the tumor is unresectable and/or chemorefractory...
  81. Kandeel S, Megahed A, Arnaout F, Constable P. Evaluation and Comparison of 2 On-Farm Tests for Estimating Somatic Cell Count in Quarter Milk Samples from Lactating Dairy Cattle. J Vet Intern Med. 2017;: pubmed publisher
    The somatic cell count (SCC) is commonly used to monitor udder health and diagnose subclinical intramammary infection (IMI) in dairy cattle.
  82. Richard M, Amici J, Basset Seguin N, Claudel J, Cribier B, Dreno B. Management of actinic keratosis at specific body sites in patients at high risk of carcinoma lesions: expert consensus from the AKTeam™ of expert clinicians. J Eur Acad Dermatol Venereol. 2017;: pubmed publisher
    ..If left untreated, AK may progress to invasive squamous cell carcinoma (SCC), although the rate of progression is low...
  83. Hamada K, Shinomiya H, Asano Y, Kihana T, Iwamoto M, Hanakawa Y, et al. Molecular cloning of human squamous cell carcinoma antigen 1 gene and characterization of its promoter. Biochim Biophys Acta. 2001;1518:124-31 pubmed
    ..Molecular cloning of the SCCA genomic region has revealed the presence of two tandemly arrayed genes, SCCA1 and SCCA2, which are 95% identical in nucleotide sequence...
  84. Salmenperä P, Karhemo P, Räsänen K, Laakkonen P, Vaheri A. Fibroblast spheroids as a model to study sustained fibroblast quiescence and their crosstalk with tumor cells. Exp Cell Res. 2016;345:17-24 pubmed publisher
    ..generation of quiescent fibroblasts in multicellular spheroids and their effects on squamous cell carcinoma (SCC) growth in soft-agarose and xenograft models...
  85. Cardesa A, Nadal A, Alos L, Lloreta Trull J, Ferlito A. Sebaceous Differentiation in Squamous Cell Carcinoma of the Larynx and Adjacent Pharynx: Case Report with Review and Discussion of the Literature. Head Neck Pathol. 2018;12:118-122 pubmed publisher
    Among the variants of squamous cell carcinoma (SCC) of the head and neck arising in mucosal surfaces, examples with sebaceous differentiation are exceedingly rare...
  86. Schmitz E, Herwig Carl M, Holz F, Loeffler K. Sebaceous gland carcinoma of the ocular adnexa - variability in clinical and histological appearance with analysis of immunohistochemical staining patterns. Graefes Arch Clin Exp Ophthalmol. 2017;255:2277-2285 pubmed publisher
    ..were specimens from four patients with basal cell carcinoma (BCC) and four patients with squamous cell carcinoma (SCC). Histological and immunohistochemical analysis included stains for HE, cytokeratins (CKpan, Cam5...
  87. Long W, Khayat K, Lemieux G, Hwang S, Han N. Performance-Based Specifications of Workability Characteristics of Prestressed, Precast Self-Consolidating Concrete-A North American Prospective. Materials (Basel). 2014;7:2474-2489 pubmed publisher
    ..In total, 33 self-consolidating concrete (SCC) mixtures made with various mixture proportioning parameters, including maximum size and type of aggregate, type ..
  88. Jitonnom J, Ketudat Cairns J, Hannongbua S. QM/MM modeling of the hydrolysis and transfructosylation reactions of fructosyltransferase from Aspergillus japonicas, an enzyme that produces prebiotic fructooligosaccharide. J Mol Graph Model. 2017;79:175-184 pubmed publisher
    ..Based on the SCC-DFTB/MM simulations of sucrose complexes of wildtype and D191A mutant FT, Asp191 is shown to be responsible for the ..
  89. Ricciardiello F, Caraglia M, Iorio B, Abate T, Boccellino M, Colella G, et al. Aggressiveness pattern and second primary tumor risk associated with basaloid squamous cell carcinoma of the larynx. Oncotarget. 2017;8:95791-95798 pubmed publisher
    Basaloid squamous cell carcinoma (BSCC) is a rare, aggressive and distinct variant of squamous cell carcinoma (SCC) of the upper respiratory and digestive tract...
  90. Feng X, Li J, Li J, Han Z, Xing R. Serum SCCA, Cyfra 21-1, EGFR and Cyclin D1 levels in patients with oral squamous cell carcinoma. Int J Biol Markers. 2010;25:93-8 pubmed
  91. Song W, Liu X, Tian X, Wang W, Liang C, Zhang T, et al. Utility of squamous cell carcinoma antigen, carcinoembryonic antigen, Cyfra 21-1 and neuron specific enolase in lung cancer diagnosis: a prospective study from China. Chin Med J (Engl). 2011;124:3244-8 pubmed
    ..Serum levels of four tumor markers including squamous cell carcinoma antigen (SCC), carcinoembryonic antigen (CEA), Cyfra 21-1 and neuron specific enolase (NSE) were assayed for each patient...
  92. Tay G, Iyer N, Ong W, Tai D, Ang M, Ha T, et al. Outcomes and Prognostic Factors of Radiation-Induced and De Novo Head and Neck Squamous Cell Carcinomas. Otolaryngol Head Neck Surg. 2016;154:880-7 pubmed publisher
    ..treatment patterns, and survival outcomes between radiation-induced squamous cell carcinoma (RISCC) and de novo SCC (DNSCC) of the head and neck, as well as identify prognostic factors in these patients. Case-control study...