serotonin transporter

Summary

Gene Symbol: serotonin transporter
Description: solute carrier family 6 member 4
Alias: 5-HTT, 5-HTTLPR, 5HTT, HTT, OCD1, SERT, SERT1, hSERT, sodium-dependent serotonin transporter, 5-hydroxytryptamine (serotonin) transporter, 5HT transporter, Na+/Cl- dependent serotonin transporter, serotonin transporter 1, solute carrier family 6 (neurotransmitter transporter), member 4, solute carrier family 6 (neurotransmitter transporter, serotonin), member 4
Species: human
Products:     serotonin transporter

Top Publications

  1. Risch N, Herrell R, Lehner T, Liang K, Eaves L, Hoh J, et al. Interaction between the serotonin transporter gene (5-HTTLPR), stressful life events, and risk of depression: a meta-analysis. JAMA. 2009;301:2462-71 pubmed publisher
    ..disorders through inclusion of environmental exposures following the report of an interaction between the serotonin transporter linked polymorphic region (5-HTTLPR) and stressful life events on an increased risk of major depression...
  2. Lau J, Goldman D, Buzas B, Fromm S, Guyer A, Hodgkinson C, et al. Amygdala function and 5-HTT gene variants in adolescent anxiety and major depressive disorder. Biol Psychiatry. 2009;65:349-55 pubmed publisher
    Associations between a functional polymorphism in the serotonin transporter gene and amygdala activation have been found in healthy, depressed, and anxious adults...
  3. Murphy D, Moya P. Human serotonin transporter gene (SLC6A4) variants: their contributions to understanding pharmacogenomic and other functional G×G and G×E differences in health and disease. Curr Opin Pharmacol. 2011;11:3-10 pubmed publisher
    Recent major findings from studies of SLC6A4 and its corresponding protein, the serotonin (5-HT) transporter (SERT) in humans, rodents and non-human primates indicate that combinations of SLC6A4 non-coding 5', 3' UTRs and intronic regions ..
  4. Cevoli S, Marzocchi N, Capellari S, Scapoli C, Pierangeli G, Grimaldi D, et al. Lack of association between five serotonin metabolism-related genes and medication overuse headache. J Headache Pain. 2010;11:53-8 pubmed publisher
    ..We performed a genetic association study using polymorphisms of five serotonin metabolism-related genes: serotonin transporter (5HTT), serotonin receptor 1A(5-HT1A), serotonin receptor 1B (5-HT1B), serotonin receptor 2A (5-HT2A) and ..
  5. Huezo Diaz P, Uher R, Smith R, Rietschel M, Henigsberg N, Marusic A, et al. Moderation of antidepressant response by the serotonin transporter gene. Br J Psychiatry. 2009;195:30-8 pubmed publisher
    There have been conflicting reports on whether the length polymorphism in the promoter of the serotonin transporter gene (5-HTTLPR) moderates the antidepressant effects of selective serotonin reuptake inhibitors (SSRIs)...
  6. Terracciano A, Balaci L, Thayer J, Scally M, Kokinos S, Ferrucci L, et al. Variants of the serotonin transporter gene and NEO-PI-R Neuroticism: No association in the BLSA and SardiNIA samples. Am J Med Genet B Neuropsychiatr Genet. 2009;150B:1070-7 pubmed publisher
    The polymorphism in the serotonin transporter gene promoter region (5-HTTLPR) is by far the most studied variant hypothesized to influence Neuroticism-related personality traits...
  7. Fergusson D, Horwood L, Miller A, Kennedy M. Life stress, 5-HTTLPR and mental disorder: findings from a 30-year longitudinal study. Br J Psychiatry. 2011;198:129-35 pubmed publisher
    ..have raised concerns about the replicability of gene × environment interactions involving the serotonin transporter gene (5-HTTLPR) in moderating the associations between adverse life events and mental disorders...
  8. Caspi A, Hariri A, Holmes A, Uher R, Moffitt T. Genetic sensitivity to the environment: the case of the serotonin transporter gene and its implications for studying complex diseases and traits. Am J Psychiatry. 2010;167:509-27 pubmed publisher
    ..review research about one of the most extensive areas of inquiry: variation in the promoter region of the serotonin transporter gene (SLC6A4; also known as 5-HTT) and its contribution to stress sensitivity...
  9. Terracciano A, Tanaka T, Sutin A, Deiana B, Balaci L, Sanna S, et al. BDNF Val66Met is associated with introversion and interacts with 5-HTTLPR to influence neuroticism. Neuropsychopharmacology. 2010;35:1083-9 pubmed publisher
    ..Finally, on the basis of recent reports of an epistatic effect between BDNF and the serotonin transporter, we explored a Val66Met x 5-HTTLPR interaction in a larger SardiNIA sample (n=2333)...

More Information

Publications128 found, 100 shown here

  1. Saito Y, Larson J, Atkinson E, Ryu E, Almazar A, Petersen G, et al. The role of 5-HTT LPR and GN?3 825C>T polymorphisms and gene-environment interactions in irritable bowel syndrome (IBS). Dig Dis Sci. 2012;57:2650-7 pubmed
    Smaller studies have evaluated SLC6A4 5-HTTLPR and GN?3 825C>T polymorphisms in IBS, and interactions between 5-HTT LPR with life events have been reported in the psychiatric literature, but gene-environment studies in IBS are lacking...
  2. Schürks M, Rist P, Kurth T. STin2 VNTR polymorphism in the serotonin transporter gene and migraine: pooled and meta-analyses. J Headache Pain. 2010;11:317-26 pubmed publisher
    ..12 alleles compared to STin2.12 alleles, respectively, 10/12 and 10/10 genotypes compared to the 12/12 genotype against migraine among populations of European descent. Associations in non-European populations may differ. ..
  3. Roiser J, De Martino B, Tan G, Kumaran D, Seymour B, Wood N, et al. A genetically mediated bias in decision making driven by failure of amygdala control. J Neurosci. 2009;29:5985-91 pubmed publisher
    Genetic variation at the serotonin transporter-linked polymorphic region (5-HTTLPR) is associated with altered amygdala reactivity and lack of prefrontal regulatory control...
  4. Mellman T, Alim T, Brown D, Gorodetsky E, Buzas B, Lawson W, et al. Serotonin polymorphisms and posttraumatic stress disorder in a trauma exposed African American population. Depress Anxiety. 2009;26:993-7 pubmed publisher
    ..The objective of our study was to determine if a variable length polymorphism for the promoter regions of the 5HT transporter (5HTTLPR), and/or a substitution polymorphism in the promoter region for the 5HT2A receptor, would be ..
  5. Pérez Edgar K, Bar Haim Y, McDermott J, Gorodetsky E, Hodgkinson C, Goldman D, et al. Variations in the serotonin-transporter gene are associated with attention bias patterns to positive and negative emotion faces. Biol Psychol. 2010;83:269-71 pubmed publisher
    ..The data indicate a linear relation between 5-HTTLPR allelic status and attention biases to emotion, demonstrating a genetic mechanism for biased attention using ecologically valid stimuli that target socioemotional adaptation. ..
  6. Araya R, Hu X, Heron J, ENOCH M, Evans J, Lewis G, et al. Effects of stressful life events, maternal depression and 5-HTTLPR genotype on emotional symptoms in pre-adolescent children. Am J Med Genet B Neuropsychiatr Genet. 2009;150B:670-82 pubmed publisher
    There has been a large but inconsistent literature on interactions between the 5-HTTLPR polymorphism of the serotonin transporter gene and adversity on emotional disorders...
  7. Lewis G, Mulligan J, Wiles N, Cowen P, Craddock N, Ikeda M, et al. Polymorphism of the 5-HT transporter and response to antidepressants: randomised controlled trial. Br J Psychiatry. 2011;198:464-71 pubmed publisher
    ..To test the hypothesis that patients homozygous for the long (insertion) polymorphism of the serotonin transporter (5-HTTLPR) have an increased response to SSRI antidepressants but not to NARI antidepressants...
  8. Konneker T, Crowley J, Quackenbush C, Keefe R, Perkins D, Stroup T, et al. No association of the serotonin transporter polymorphisms 5-HTTLPR and RS25531 with schizophrenia or neurocognition. Am J Med Genet B Neuropsychiatr Genet. 2010;153B:1115-7 pubmed publisher
    A promoter polymorphism in the serotonin transporter gene has been widely studied in neuropsychiatry. We genotyped the 5-HTTLPR/rs25531 triallelic polymorphism in 728 schizophrenia cases from the CATIE study and 724 control subjects...
  9. Goodyer I, Bacon A, Ban M, Croudace T, Herbert J. Serotonin transporter genotype, morning cortisol and subsequent depression in adolescents. Br J Psychiatry. 2009;195:39-45 pubmed publisher
    The short (s) allele of the serotonin transporter gene promoter (5-HTTLPR) may be associated with exposure to social adversities and the subsequent onset of depressive illness in adulthood...
  10. Lenze E, Munin M, Ferrell R, Pollock B, Skidmore E, Lotrich F, et al. Association of the serotonin transporter gene-linked polymorphic region (5-HTTLPR) genotype with depression in elderly persons after hip fracture. Am J Geriatr Psychiatry. 2005;13:428-32 pubmed
    The authors examined the serotonin transporter gene-linked polymorphic region (5-HTTLPR) as a predictor of major depressive disorder and depressive symptoms after hip fracture, a common stressful medical event.
  11. Owens M, Goodyer I, Wilkinson P, Bhardwaj A, Abbott R, Croudace T, et al. 5-HTTLPR and early childhood adversities moderate cognitive and emotional processing in adolescence. PLoS ONE. 2012;7:e48482 pubmed publisher
    Polymorphisms in the promoter region of the serotonin transporter gene (5-HTTLPR) and exposure to early childhood adversities (CA) are independently associated with individual differences in cognitive and emotional processing...
  12. Reimold M, Knobel A, Rapp M, Batra A, Wiedemann K, Ströhle A, et al. Central serotonin transporter levels are associated with stress hormone response and anxiety. Psychopharmacology (Berl). 2011;213:563-72 pubmed publisher
    ..by both stress hormone dysregulation and serotonergic dysfunction, reflected by altered thalamic serotonin transporter (5-HTT) levels...
  13. Wankerl M, Miller R, Kirschbaum C, Hennig J, Stalder T, Alexander N. Effects of genetic and early environmental risk factors for depression on serotonin transporter expression and methylation profiles. Transl Psychiatry. 2014;4:e402 pubmed publisher
    The serotonin transporter (SERT) gene-linked polymorphic region (5-HTTLPR) has been implicated in moderating the link between life stress and depression...
  14. Zhao J, Goldberg J, Bremner J, Vaccarino V. Association between promoter methylation of serotonin transporter gene and depressive symptoms: a monozygotic twin study. Psychosom Med. 2013;75:523-9 pubmed publisher
    Epigenetic mechanisms have been implicated in the pathogenesis of psychiatric disorders. The serotonin transporter gene (SLC6A4) is a key candidate gene for depression...
  15. Farjadian S, Fakhraei B, Moeini M, Nasiri M, Fattahi M. Serotonin transporter gene polymorphisms in Southwestern Iranian patients with irritable bowel syndrome. Arab J Gastroenterol. 2013;14:59-62 pubmed publisher
    ..Transcription activity of the serotonin transporter gene is affected by some polymorphisms in this gene...
  16. Areeshi M, Haque S, Panda A, Mandal R. A serotonin transporter gene (SLC6A4) polymorphism is associated with reduced risk of irritable bowel syndrome in American and Asian population: a meta-analysis. PLoS ONE. 2013;8:e75567 pubmed publisher
    Association studies of serotonin transporter gene SLC6A4 I/S polymorphism and irritable bowel syndrome (IBS) have shown inconsistent and contradictory results among different populations...
  17. Zhang H, Xu M, Xia J, Qin R. Association between serotonin transporter (SERT) gene polymorphism and idiopathic pulmonary arterial hypertension: a meta-analysis and review of the literature. Metabolism. 2013;62:1867-75 pubmed publisher
    Idiopathic pulmonary arterial hypertension (IPAH) is a rare and often fatal disease of unknown etiology. Serotonin transporter (SERT) protein, whose genes can have two allelic forms, namely long (L) and short (S), is suspected to be ..
  18. Vinberg M, Miskowiak K, Kessing L. Serotonin transporter genotype, salivary cortisol, neuroticism and life events: impact on subsequent psychopathology in healthy twins at high and low risk for affective disorder. Prog Neuropsychopharmacol Biol Psychiatry. 2014;48:193-8 pubmed publisher
    To investigate if cortisol alone or in interaction with other risk factors (familial risk, the serotonin transporter genotype, neuroticism and life events (LEs)) predicts onset of psychiatric disorder in healthy individuals at heritable ..
  19. Gressier F, Calati R, Balestri M, Marsano A, Alberti S, Antypa N, et al. The 5-HTTLPR polymorphism and posttraumatic stress disorder: a meta-analysis. J Trauma Stress. 2013;26:645-53 pubmed publisher
    ..Variation in the 5-HTTLPR polymorphism of the serotonin transporter gene has been hypothesized to affect risk for PTSD...
  20. Rahbek Clemmensen T, Bay T, Eriksen J, Gether U, Jørgensen T. The serotonin transporter undergoes constitutive internalization and is primarily sorted to late endosomes and lysosomal degradation. J Biol Chem. 2014;289:23004-19 pubmed publisher
    The serotonin transporter (SERT) plays a critical role in regulating serotonin signaling by mediating reuptake of serotonin from the extracellular space...
  21. Antypa N, Serretti A, Rujescu D. Serotonergic genes and suicide: a systematic review. Eur Neuropsychopharmacol. 2013;23:1125-42 pubmed publisher
    ..examining the association between various serotonergic genes (Tryptophan Hydroxylase genes: TPH1; TPH2, Serotonin Transporter gene: 5-HTTLPR in SLC6A4, Serotonin Receptor genes: HTR1A, HTR2A, HTR1B, HTR2C and Monoamine Oxidase A ..
  22. Xu H, Zhang Q, Hou X, Wang Q, Xu Y, Li L, et al. The effect of the polymorphisms of 5-HTTLPR on new onset of depression in patients who underwent pacemaker implantation. Psychiatr Genet. 2014;24:70-4 pubmed publisher
    To study the role of serotonin transporter gene (5-HTTLPR) polymorphisms in the incidence of depression in a Chinese cohort who underwent pacemaker (PM) implantation. A total of 294 patients treated with PMs were enrolled...
  23. Xu J, Cheng Y, Chen B, Bai R, Li S, Xu X, et al. Depression in systemic lupus erythematosus patients is associated with link-polymorphism but not methylation status of the 5HTT promoter region. Lupus. 2013;22:1001-10 pubmed publisher
    ..The present study was conducted to explore whether the polymorphism and methylation status of the serotonin transporter gene (5HTT) promoter region (PR-5HTT) contribute to depression in SLE patients from both genetic and ..
  24. Seimandi M, Seyer P, Park C, Vandermoere F, Chanrion B, Bockaert J, et al. Calcineurin interacts with the serotonin transporter C-terminus to modulate its plasma membrane expression and serotonin uptake. J Neurosci. 2013;33:16189-99 pubmed publisher
    ..serotonergic transmission critically depends on the rate of serotonin reuptake via its plasma membrane transporter (SERT)...
  25. Belsky J, Beaver K. Cumulative-genetic plasticity, parenting and adolescent self-regulation. J Child Psychol Psychiatry. 2011;52:619-26 pubmed publisher
    ..To afford comparative evaluation of differential-susceptibility vs. diathesis-stress models of environmental action, future G×E work should focus on positive as well as negative environmental conditions and developmental outcomes. ..
  26. Sakai J, Lessem J, Haberstick B, Hopfer C, Smolen A, Ehringer M, et al. Case-control and within-family tests for association between 5HTTLPR and conduct problems in a longitudinal adolescent sample. Psychiatr Genet. 2007;17:207-14 pubmed
    Several recent studies have reported an association between the serotonin transporter 5HTTLPR (s-allele) and aggression; however, non-replications have also been reported. Inconsistencies may be explained by gene-environment interactions...
  27. Surguladze S, Elkin A, Ecker C, Kalidindi S, Corsico A, Giampietro V, et al. Genetic variation in the serotonin transporter modulates neural system-wide response to fearful faces. Genes Brain Behav. 2008;7:543-51 pubmed publisher
    ..The extent to which a genetic variation of serotonin transporter gene 5-HTTLPR impacts functional connectivity between the amygdala and the other components of this neural ..
  28. Matsushita S, Yoshino A, Murayama M, Kimura M, Muramatsu T, Higuchi S. Association study of serotonin transporter gene regulatory region polymorphism and alcoholism. Am J Med Genet. 2001;105:446-50 pubmed
    ..associations between a functional biallelic repetitive element in the 5' regulatory region of the serotonin transporter gene (5-HTTLPR) and alcoholic subjects who have either dissocial personality disorder or severe withdrawal ..
  29. van Lelyveld N, Linde J, Schipper M, Samsom M. Candidate genotypes associated with functional dyspepsia. Neurogastroenterol Motil. 2008;20:767-73 pubmed publisher
    ..Polymorphisms in genes encoding the serotonin receptor type three A subunit (HTR3A), the serotonin transporter (SERT) and the G-protein beta3 subunit (GNB3) were analysed...
  30. Coutinho A, Oliveira G, Morgadinho T, Fesel C, Macedo T, Bento C, et al. Variants of the serotonin transporter gene (SLC6A4) significantly contribute to hyperserotonemia in autism. Mol Psychiatry. 2004;9:264-71 pubmed
    ..We have examined the association of platelet serotonin levels with two SLC6A4 polymorphisms, 5-HTT gene-linked polymorphic region (HTTLPR) in the promoter and intron 2 variable number of tandem repeats (VNTR), in a ..
  31. Guimarães A, Zeni C, Polanczyk G, Genro J, Roman T, Rohde L, et al. Serotonin genes and attention deficit/hyperactivity disorder in a Brazilian sample: preferential transmission of the HTR2A 452His allele to affected boys. Am J Med Genet B Neuropsychiatr Genet. 2007;144B:69-73 pubmed
    ..In the present study, we investigated a polymorphism in the promoter region of the serotonin transporter (SLC6A4) and two polymorphisms (-1438 A > G and His452Tyr) in the serotonin 5-HTR2A receptor gene using ..
  32. Pacheco J, Beevers C, Benavides C, McGeary J, Stice E, Schnyer D. Frontal-limbic white matter pathway associations with the serotonin transporter gene promoter region (5-HTTLPR) polymorphism. J Neurosci. 2009;29:6229-33 pubmed publisher
    Variation in the serotonin transporter gene-linked polymorphic region (5-HTTLPR) has been associated with heightened neural activity in limbic and prefrontal regions in response to emotional stimuli...
  33. Torres G, Yao W, Mohn A, Quan H, Kim K, Levey A, et al. Functional interaction between monoamine plasma membrane transporters and the synaptic PDZ domain-containing protein PICK1. Neuron. 2001;30:121-34 pubmed
    ..These findings indicate a role for PDZ-mediated protein interactions in the localization, expression, and function of monoamine transporters. ..
  34. Kohen R, Cain K, Mitchell P, Becker K, Buzaitis A, Millard S, et al. Association of serotonin transporter gene polymorphisms with poststroke depression. Arch Gen Psychiatry. 2008;65:1296-302 pubmed publisher
    Polymorphisms of the serotonin transporter gene (SERT) have been associated with mental illness...
  35. Luo S, Wang F, Xie Z, Huang X, Lu Y. [Study on the correlation of the 5-HTTLPR polymorphism with premature ejaculation in Han Chinese population]. Beijing Da Xue Xue Bao Yi Xue Ban. 2011;43:514-8 pubmed
    ..The gene polymorphism of the 5-HTT was detected by polymerase chain reaction analysis in all the cases, and the gene frequency differences among the ..
  36. Willeit M, Praschak Rieder N, Neumeister A, Zill P, Leisch F, Stastny J, et al. A polymorphism (5-HTTLPR) in the serotonin transporter promoter gene is associated with DSM-IV depression subtypes in seasonal affective disorder. Mol Psychiatry. 2003;8:942-6 pubmed
    ..The expression of the serotonin transporter (5-HTT) is regulated in part by an insertion/deletion polymorphism in the serotonin transporter gene ..
  37. Graff Guerrero A, de la Fuente Sandoval C, Camarena B, Gómez Martín D, Apiquian R, Fresan A, et al. Frontal and limbic metabolic differences in subjects selected according to genetic variation of the SLC6A4 gene polymorphism. Neuroimage. 2005;25:1197-204 pubmed
    Allelic variants in the promoter region of the serotonin transporter (5-HTT) gene have been implicated in several psychiatric disorders and personality traits...
  38. de Lima K, Guembarovski R, Oda J, Ramos G, Oliveira B, Cavalli I, et al. Association between the STin2 VNTR polymorphism and smoking behavior in oral cancer patients and healthy individuals. Clin Exp Med. 2012;12:13-9 pubmed publisher
    ..supporting the beneficial effect of selective serotonin reuptake for quitting smoking suggesting that the serotonin transporter (5-HTT) is a plausible target for the understanding and elucidation of smoking behavior...
  39. Vaske J, Newsome J, Wright J. Interaction of serotonin transporter linked polymorphic region and childhood neglect on criminal behavior and substance use for males and females. Dev Psychopathol. 2012;24:181-93 pubmed publisher
    ..The current study investigates whether a genetic variant (serotonin transporter linked polymorphic region [5-HTTLPR]) in the 5-hydroxytryptamine (5-HTT) gene moderates the effect of ..
  40. Yoshida K, Takahashi H, Higuchi H, Kamata M, Ito K, Sato K, et al. Prediction of antidepressant response to milnacipran by norepinephrine transporter gene polymorphisms. Am J Psychiatry. 2004;161:1575-80 pubmed
    ..The purpose of the present study was to determine whether norepinephrine transporter gene (NET) and serotonin transporter gene (5-HTT) polymorphisms are associated with the antidepressant response to milnacipran, a dual ..
  41. Bonvicini C, Minelli A, Scassellati C, Bortolomasi M, Segala M, Sartori R, et al. Serotonin transporter gene polymorphisms and treatment-resistant depression. Prog Neuropsychopharmacol Biol Psychiatry. 2010;34:934-9 pubmed publisher
    ..Some polymorphisms in the promoter region of the serotonin transporter gene (SLC6A4) are likely to be involved in the pathogenesis/treatment of MDD; however, no data are ..
  42. Brockmann H, Zobel A, Schuhmacher A, Daamen M, Joe A, Biermann K, et al. Influence of 5-HTTLPR polymorphism on resting state perfusion in patients with major depression. J Psychiatr Res. 2011;45:442-51 pubmed publisher
    ..While the clinical impact of these findings will need to be further investigated in larger cohort studies, the necessity to monitor and to account for individual 5-HTTLPR-status in future MDD imaging studies is highly recommended. ..
  43. Furmark T, Henningsson S, Appel L, Ahs F, Linnman C, Pissiota A, et al. Genotype over-diagnosis in amygdala responsiveness: affective processing in social anxiety disorder. J Psychiatry Neurosci. 2009;34:30-40 pubmed
    ..Emotion activation studies comparing amygdala excitability in patient and control groups could benefit from taking variation in 5-HT-related genes into account. ..
  44. Tharoor H, Lobos E, Todd R, Reiersen A. Association of dopamine, serotonin, and nicotinic gene polymorphisms with methylphenidate response in ADHD. Am J Med Genet B Neuropsychiatr Genet. 2008;147B:527-30 pubmed
    ..D4 variable number tandem repeat (DRD4VNTR), nicotinic acetylcholine receptor alpha 4 subunit (CHRNA4) and serotonin transporter promoter (SLC6A4-5HTTLPR) are under consideration as potential risk factors for attention-deficit/..
  45. Wilkie M, Smith G, Day R, Matthews K, Smith D, Blackwood D, et al. Polymorphisms in the SLC6A4 and HTR2A genes influence treatment outcome following antidepressant therapy. Pharmacogenomics J. 2009;9:61-70 pubmed publisher
    ..In this study, nine polymorphisms in four serotonin receptor genes (HTR1B, HTR2A, HTR5A and HTR6) and the serotonin transporter gene (SLC6A4) were analysed to investigate their influence on antidepressant response in a well-..
  46. Brummett B, Muller C, Collins A, Boyle S, Kuhn C, Siegler I, et al. 5-HTTLPR and gender moderate changes in negative affect responses to tryptophan infusion. Behav Genet. 2008;38:476-83 pubmed publisher
    Expression of the serotonin transporter is affected by the genotype of the 5-HTTLPR (short and long forms) as well as the genotype of the SNP rs25531 within this region...
  47. Mileva Seitz V, Kennedy J, Atkinson L, Steiner M, Levitan R, Matthews S, et al. Serotonin transporter allelic variation in mothers predicts maternal sensitivity, behavior and attitudes toward 6-month-old infants. Genes Brain Behav. 2011;10:325-33 pubmed publisher
    ..In a sample of 204 mothers, we assessed maternal genotype at the serotonin transporter-linked polymorphic region (5-HTTLPR) and an adjacent upstream polymorphism (rs25531), together giving rise ..
  48. Passamonti L, Cerasa A, Gioia M, Magariello A, Muglia M, Quattrone A, et al. Genetically dependent modulation of serotonergic inactivation in the human prefrontal cortex. Neuroimage. 2008;40:1264-73 pubmed publisher
    ..Although with conflicting findings, the monoamine oxidase-A (MAOA) and the serotonin transporter (5HTT) gene polymorphisms have been associated with an increased risk to develop impulsive and aggressive ..
  49. Sikander A, Rana S, Sinha S, Prasad K, Arora S, Sharma S, et al. Serotonin transporter promoter variant: Analysis in Indian IBS patients and control population. J Clin Gastroenterol. 2009;43:957-61 pubmed publisher
    Studies of serotonin reuptake transporter (SERT-P) polymorphism and irritable bowel syndrome (IBS) have shown diverse results among different populations, which might be due to racial and ethnic difference...
  50. Markoutsaki T, Karantanos T, Gazouli M, Anagnou N, Ladas S, Karamanolis D. Serotonin transporter and G protein beta 3 subunit gene polymorphisms in Greeks with irritable bowel syndrome. Dig Dis Sci. 2011;56:3276-80 pubmed publisher
    Polymorphisms in the serotonin transporter (SERT) and G protein ?3 subunit (GNB3) genes might contribute to the pathophysiology of irritable bowel syndrome (IBS)...
  51. Oberlander T, Bonaguro R, Misri S, Papsdorf M, Ross C, Simpson E. Infant serotonin transporter (SLC6A4) promoter genotype is associated with adverse neonatal outcomes after prenatal exposure to serotonin reuptake inhibitor medications. Mol Psychiatry. 2008;13:65-73 pubmed
    ..In adults, effects of these medications may be related to the genotype for the serotonin transporter (SLC6A4) promoter...
  52. Beevers C, Pacheco J, Clasen P, McGeary J, Schnyer D. Prefrontal morphology, 5-HTTLPR polymorphism and biased attention for emotional stimuli. Genes Brain Behav. 2010;9:224-33 pubmed publisher
    ..e. spatial cueing task). Participants were also genotyped for the serotonin transporter-linked promoter region (5-HTTLPR) gene...
  53. Sadeh N, Javdani S, Jackson J, Reynolds E, Potenza M, Gelernter J, et al. Serotonin transporter gene associations with psychopathic traits in youth vary as a function of socioeconomic resources. J Abnorm Psychol. 2010;119:604-9 pubmed publisher
    ..Consequently, we investigated the influence of polymorphic variation at the serotonin transporter protein gene (SLC6A4) and socioeconomic resources (SES) on psychopathic traits in youth across two ..
  54. Koenen K, Uddin M, Chang S, Aiello A, Wildman D, Goldmann E, et al. SLC6A4 methylation modifies the effect of the number of traumatic events on risk for posttraumatic stress disorder. Depress Anxiety. 2011;28:639-47 pubmed publisher
    ..We examined whether serotonin transporter (SLC6A4) promoter genotype and methylation status modified the association between number of traumatic ..
  55. Peyrot W, Middeldorp C, Jansen R, Smit J, de Geus E, Hottenga J, et al. Strong effects of environmental factors on prevalence and course of major depressive disorder are not moderated by 5-HTTLPR polymorphisms in a large Dutch sample. J Affect Disord. 2013;146:91-9 pubmed publisher
    ..Environmental factors were not assessed before the onset of MDD. Environmental factors had a strong impact on the presence and course of MDD, but no evidence for gene-by-environment interaction was found. ..
  56. Szilagyi A, Boor K, Orosz I, Szantai E, Szekely A, Kalasz H, et al. Contribution of serotonin transporter gene polymorphisms to pediatric migraine. Headache. 2006;46:478-85 pubmed
    The serotonin transporter gene is a promising candidate locus for the genetic susceptibility of migraine...
  57. Dragan W, Oniszczenko W. Association of a functional polymorphism in the serotonin transporter gene with personality traits in females in a Polish population. Neuropsychobiology. 2006;54:45-50 pubmed
    ..5, p = 0.012). These findings support a role of the 5-HTTLPR polymorphism in the modulation of personality and temperamental traits. ..
  58. Lee B, Ham B. Serotonergic genes and amygdala activity in response to negative affective facial stimuli in Korean women. Genes Brain Behav. 2008;7:899-905 pubmed publisher
    ..All participants were genotyped with regard to the following polymorphisms: the serotonin transporter-gene-linked polymorphic region (5-HTTLPR), tryptophan hydroxylase 2 (TPH2) G(-703)T, 5-HT(1A) C(-1019)G ..
  59. Korkhov V, Holy M, Freissmuth M, Sitte H. The conserved glutamate (Glu136) in transmembrane domain 2 of the serotonin transporter is required for the conformational switch in the transport cycle. J Biol Chem. 2006;281:13439-48 pubmed
    ..Here, we focused on Glu136 of the serotonin transporter (SERT); this residue is conserved in transmembrane domain 2 of neurotransmitter/sodium symporters and ..
  60. Kwang T, Wells T, McGeary J, Swann W, Beevers C. Association of the serotonin transporter promoter region polymorphism with biased attention for negative word stimuli. Depress Anxiety. 2010;27:746-51 pubmed publisher
    ..These findings replicate previous work and suggest that 5-HTTLPR L(A) homozygotes possess a protective attentional bias that may decrease susceptibility to depression and anxiety. ..
  61. Manor I, Eisenberg J, Tyano S, Sever Y, Cohen H, Ebstein R, et al. Family-based association study of the serotonin transporter promoter region polymorphism (5-HTTLPR) in attention deficit hyperactivity disorder. Am J Med Genet. 2001;105:91-5 pubmed
    ..Recently, a common 44-bp deletion in the promoter region of the serotonin transporter (5-HTTLPR) that results in reduced transcription and lower transporter protein levels was described...
  62. Munafo M, Clark T, Johnstone E, Murphy M, Walton R. The genetic basis for smoking behavior: a systematic review and meta-analysis. Nicotine Tob Res. 2004;6:583-97 pubmed
    ..The meta-analysis included data on the DRD2, DAT, 5HTT, and CYP2A6 genes and smoking behavior...
  63. Lin P. Meta-analysis of the association of serotonin transporter gene polymorphism with obsessive-compulsive disorder. Prog Neuropsychopharmacol Biol Psychiatry. 2007;31:683-9 pubmed
    ..Many studies examined the association between OCD and a functional polymorphism of the serotonin transporter gene promoter (5-HTTLPR) but yielded inconsistent results...
  64. Ezaki N, Nakamura K, Sekine Y, Thanseem I, Anitha A, Iwata Y, et al. Short allele of 5-HTTLPR as a risk factor for the development of psychosis in Japanese methamphetamine abusers. Ann N Y Acad Sci. 2008;1139:49-56 pubmed publisher
    ..Our PET studies revealed that the serotonin transporter (5-HTT) density in global brain regions is significantly lower in MAP abusers...
  65. Gillihan S, Rao H, Brennan L, Wang D, Detre J, Sankoorikal G, et al. Serotonin transporter genotype modulates the association between depressive symptoms and amygdala activity among psychiatrically healthy adults. Psychiatry Res. 2011;193:161-7 pubmed publisher
    ..the biological bases of depression vulnerability have revealed that both the short allele of the serotonin transporter-linked polymorphic region (5-HTTLPR) and activity in the amygdala are associated with depression...
  66. Mendlewicz J, Massat I, Souery D, Del Favero J, Oruc L, Nothen M, et al. Serotonin transporter 5HTTLPR polymorphism and affective disorders: no evidence of association in a large European multicenter study. Eur J Hum Genet. 2004;12:377-82 pubmed
    The available data from preclinical and pharmacological studies on the role of the serotonin transporter (5-HTT) support the hypothesis that a dysfunction in brain serotonergic system activity contributes to the vulnerability to ..
  67. Brenner B, Harney J, Ahmed B, Jeffus B, Unal R, Mehta J, et al. Plasma serotonin levels and the platelet serotonin transporter. J Neurochem. 2007;102:206-15 pubmed
    ..The actions of 5HT are mediated by different types of receptors and terminated by a single 5HT transporter (SERT)...
  68. Oʼhara R, Marcus P, Thompson W, Flournoy J, Vahia I, Lin X, et al. 5-HTTLPR short allele, resilience, and successful aging in older adults. Am J Geriatr Psychiatry. 2012;20:452-6 pubmed publisher
    Resilience is proposed as a significant component of successful aging. Young adult carriers of the Serotonin Transporter Polymorphism (5-HTTLPR) short(s) allele appear to have reduced resilience to stress...
  69. Stoltenberg S, Anderson C, Nag P, Anagnopoulos C. Association between the serotonin transporter triallelic genotype and eating problems is moderated by the experience of childhood trauma in women. Int J Eat Disord. 2012;45:492-500 pubmed publisher
    This study investigated a potential interaction between the triallelic polymorphism of the serotonin transporter gene (SLC6A4) promoter and the experience of childhood trauma on the number of problem eating behaviors...
  70. Frodl T, Reinhold E, Koutsouleris N, Donohoe G, Bondy B, Reiser M, et al. Childhood stress, serotonin transporter gene and brain structures in major depression. Neuropsychopharmacology. 2010;35:1383-90 pubmed publisher
    ..hippocampal volumes and other brain alterations are associated with the tri-allelic polymorphism of the serotonin transporter and childhood stress in patients with MD and healthy subjects...
  71. Uher R, McGuffin P. The moderation by the serotonin transporter gene of environmental adversity in the aetiology of mental illness: review and methodological analysis. Mol Psychiatry. 2008;13:131-46 pubmed
    ..interaction (G x E) between a common functional polymorphism in the promoter region of the serotonin transporter gene (5-HTT) and environmental adversity on the onset of depression in humans has been found in fifteen ..
  72. Stein M, Schork N, Gelernter J. Gene-by-environment (serotonin transporter and childhood maltreatment) interaction for anxiety sensitivity, an intermediate phenotype for anxiety disorders. Neuropsychopharmacology. 2008;33:312-9 pubmed
    ..The serotonin transporter gene (SLC6A4) promoter polymorphism (5-HTTLPR) has been associated with depression, but most consistently ..
  73. Pauli Pott U, Friedel S, Friedl S, Hinney A, Hebebrand J. Serotonin transporter gene polymorphism (5-HTTLPR), environmental conditions, and developing negative emotionality and fear in early childhood. J Neural Transm (Vienna). 2009;116:503-12 pubmed publisher
    Studies on neural and behavioral correlates of the serotonin transporter gene polymorphism (5-HTTLPR) strongly suggested interaction effects between the 5-HTTLPR genotype and environmental conditions on infant emotionality development...
  74. Wankerl M, Zyriax B, Bondy B, Hinkelmann K, Windler E, Otte C. Serotonin transporter gene-linked polymorphic region (5-HTTLPR) and diurnal cortisol: A sex by genotype interaction. Biol Psychol. 2010;85:344-6 pubmed publisher
    In interaction with stressful life events, the serotonin transporter gene-linked polymorphic region (5-HTTLPR) is associated with depression. In response to stress, the hypothalamic-pituitary-adrenal (HPA) axis is activated...
  75. Palit S, Sheaff R, France C, McGlone S, Potter W, Harkness A, et al. Serotonin transporter gene (5-HTTLPR) polymorphisms are associated with emotional modulation of pain but not emotional modulation of spinal nociception. Biol Psychol. 2011;86:360-9 pubmed publisher
    The short allele of the serotonin transporter gene (5-HTTLPR) is associated with greater negative emotionality. Given that emotion modulates pain, short allele carriers (s-carriers) may also demonstrate altered pain modulation...
  76. Seeger G, Schloss P, Schmidt M. Functional polymorphism within the promotor of the serotonin transporter gene is associated with severe hyperkinetic disorders. Mol Psychiatry. 2001;6:235-8 pubmed
    ..relates to the concentration of the neurotransmitter in the synaptic cleft and is controlled by the serotonin transporter (5-HTT), which selectively removes serotonin out of the synaptic cleft...
  77. Zoroğlu S, Erdal M, Alasehirli B, Erdal N, Sivasli E, Tutkun H, et al. Significance of serotonin transporter gene 5-HTTLPR and variable number of tandem repeat polymorphism in attention deficit hyperactivity disorder. Neuropsychobiology. 2002;45:176-81 pubmed
    ..relationship between attention deficit hyperactivity disorder (ADHD) and polymorphism of the two regions of the 5-HTT gene [variable number of tandem repeats (VNTR) and 5-HTTLRR] in a sample of Turkish children...
  78. Schinka J, Busch R, Robichaux Keene N. A meta-analysis of the association between the serotonin transporter gene polymorphism (5-HTTLPR) and trait anxiety. Mol Psychiatry. 2004;9:197-202 pubmed
    Studies of the association between polymorphisms of the serotonin transporter gene (5-HTT) and trait anxiety have produced inconsistent results, raising questions about the strength of the relationship and the methodological conditions ..
  79. Lang U, Bajbouj M, Wernicke C, Rommelspacher H, Danker Hopfe H, Gallinat J. No association of a functional polymorphism in the serotonin transporter gene promoter and anxiety-related personality traits. Neuropsychobiology. 2004;49:182-4 pubmed
    Serotonergic neurotransmission, which is involved in many psychiatric disorders, is mediated by the serotonin transporter protein...
  80. Lindstedt F, Lonsdorf T, Schalling M, Kosek E, Ingvar M. Perception of thermal pain and the thermal grill illusion is associated with polymorphisms in the serotonin transporter gene. PLoS ONE. 2011;6:e17752 pubmed publisher
    ..of thermal pain thresholds is associated with genetically inferred levels of expression of the 5-HT transporter (5-HTT). Additionally, the perception of the so-called thermal grill illusion (TGI) was assessed...
  81. Pluess M, Velders F, Belsky J, van IJzendoorn M, Bakermans Kranenburg M, Jaddoe V, et al. Serotonin transporter polymorphism moderates effects of prenatal maternal anxiety on infant negative emotionality. Biol Psychiatry. 2011;69:520-5 pubmed publisher
    ..In recent years, a polymorphism in the serotonin transporter gene (5-HTTLPR) emerged as a moderator of diverse environmental influences on different outcomes, with ..
  82. Janssen P, Bakker S, Rethelyi J, Zwinderman A, Touw D, Olivier B, et al. Serotonin transporter promoter region (5-HTTLPR) polymorphism is associated with the intravaginal ejaculation latency time in Dutch men with lifelong premature ejaculation. J Sex Med. 2009;6:276-84 pubmed publisher
    ..Controls consisted of 92 Dutch Caucasian men. All men with LPE were genotyped for a 5-HTT-promoter polymorphism...
  83. Li Y, Nie Y, Xie J, Tang W, Liang P, Sha W, et al. The association of serotonin transporter genetic polymorphisms and irritable bowel syndrome and its influence on tegaserod treatment in Chinese patients. Dig Dis Sci. 2007;52:2942-9 pubmed
    ..The frequency of the L/L genotype in the serotonin transporter gene-linked polymorphic region was significantly higher in patients with constipation than in controls (25...
  84. Lanctot K, Rapoport M, Chan F, Rajaram R, Strauss J, Sicard T, et al. Genetic predictors of response to treatment with citalopram in depression secondary to traumatic brain injury. Brain Inj. 2010;24:959-69 pubmed publisher
    ..Six functional SNPs in genes related to the serotonergic system were examined: serotonin transporter (5HTTLPR including rs25531), 5HT1A C-(1019)G and 5HT2A T-(102)C, methylene tetrahydrofolate reductase (..
  85. Beevers C, Marti C, Lee H, Stote D, Ferrell R, Hariri A, et al. Associations between serotonin transporter gene promoter region (5-HTTLPR) polymorphism and gaze bias for emotional information. J Abnorm Psychol. 2011;120:187-97 pubmed publisher
    The serotonin transporter promoter region polymorphism (5-HTTLPR) is associated with neural response to negative images in brain regions involved in the experience of emotion...
  86. De Luca V, Zai G, Tharmalingam S, de Bartolomeis A, Wong G, Kennedy J. Association study between the novel functional polymorphism of the serotonin transporter gene and suicidal behaviour in schizophrenia. Eur Neuropsychopharmacol. 2006;16:268-71 pubmed
    A serotonin transporter gene linked polymorphic region (5-HTTLPR) has been investigated in several genetic association studies, including studies of schizophrenia and suicidality...
  87. Karwautz A, Campos de Sousa S, Wöber C, Wagner G, Li T, Konrad A, et al. Family-based analysis of serotonin transporter gene polymorphisms in migraine with and without aura. Cephalalgia. 2007;27:773-80 pubmed
    ..Consequently, we examined two functional VNTR polymorphisms in the serotonin transporter gene, the 5-HTTLPR and the intron 2 VNTR, in a sample of 212 family trios each with a proband with ..
  88. Olsson C, Foley D, Parkinson Bates M, Byrnes G, McKenzie M, Patton G, et al. Prospects for epigenetic research within cohort studies of psychological disorder: a pilot investigation of a peripheral cell marker of epigenetic risk for depression. Biol Psychol. 2010;83:159-65 pubmed publisher
    ..Epigenotyping was limited to promoter methylation of the serotonin transporter gene (5HTT). A transcription limiting VNTR in the 5HTT promoter (5HTTLPR) was also genotyped...
  89. Iga J, Ueno S, Yamauchi K, Motoki I, Tayoshi S, Ohta K, et al. Serotonin transporter mRNA expression in peripheral leukocytes of patients with major depression before and after treatment with paroxetine. Neurosci Lett. 2005;389:12-6 pubmed
    b>Serotonin transporter (5HTT) is thought to be involved in the pathophysiology of major depression and the target of antidepressants...
  90. David S, Munafo M, Murphy M, Walton R, Johnstone E. The serotonin transporter 5-HTTLPR polymorphism and treatment response to nicotine patch: follow-up of a randomized controlled trial. Nicotine Tob Res. 2007;9:225-31 pubmed
    ..of European ancestry who were randomized to receive active patch or placebo patch were genotyped for the serotonin transporter gene-linked polymorphic region...
  91. Wüst S, Kumsta R, Treutlein J, Frank J, Entringer S, Schulze T, et al. Sex-specific association between the 5-HTT gene-linked polymorphic region and basal cortisol secretion. Psychoneuroendocrinology. 2009;34:972-82 pubmed publisher
    A key regulator of serotonergic neurotransmission is the serotonin transporter (5-HTT) and a common 5HTT gene promoter polymorphism, termed 5HTTLPR, is associated with phenotypes related to anxiety and depression...
  92. Fortier E, Noreau A, Lepore F, Boivin M, Perusse D, Rouleau G, et al. Early impact of 5-HTTLPR polymorphism on the neural correlates of sadness. Neurosci Lett. 2010;485:261-5 pubmed publisher
    Healthy adults carrying the short (S) allele of the human serotonin transporter gene linked polymorphism (5-HTTLPR) show increased amygdala activation during visual processing of emotionally negative stimuli compared to healthy adults ..