S100A4

Summary

Gene Symbol: S100A4
Description: S100 calcium binding protein A4
Alias: 18A2, 42A, CAPL, FSP1, MTS1, P9KA, PEL98, protein S100-A4, S100 calcium-binding protein A4 (calcium protein, calvasculin, metastasin, murine placental homolog), fibroblast-specific protein-1, leukemia multidrug resistance associated protein, malignant transformation suppression 1, placental calcium-binding protein, protein Mts1
Species: human

Top Publications

  1. ncbi Isolation of a YAC clone covering a cluster of nine S100 genes on human chromosome 1q21: rationale for a new nomenclature of the S100 calcium-binding protein family
    B W Schafer
    University of Zurich, Department of Pediatrics, Switzerland
    Genomics 25:638-43. 1995
  2. ncbi Binding to intracellular targets of the metastasis-inducing protein, S100A4 (p9Ka)
    H Chen
    Molecular Medicine Research Group, University of Liverpool, Liverpool, L69 7ZB, United Kingdom
    Biochem Biophys Res Commun 286:1212-7. 2001
  3. pmc Overexpression of S100A4 in pancreatic ductal adenocarcinomas is associated with poor differentiation and DNA hypomethylation
    Christophe Rosty
    Department of Pathology, The Johns Hopkins Medical Institutions, Baltimore, Maryland 21205 2196, USA
    Am J Pathol 160:45-50. 2002
  4. pmc S100A4 (p9Ka) protein in colon carcinoma and liver metastases: association with carcinoma cells and T-lymphocytes
    S Taylor
    Cancer Tissue Bank Research Centre, University of Liverpool, P O Box 147, Liverpool, L69 7ZB, UK
    Br J Cancer 86:409-16. 2002
  5. ncbi Solution structure of human Mts1 (S100A4) as determined by NMR spectroscopy
    Kristen M Vallely
    Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, 108 North Greene Street, Baltimore, Maryland 21201, USA
    Biochemistry 41:12670-80. 2002
  6. ncbi Mts1 regulates the assembly of nonmuscle myosin-IIA
    Zhong hua Li
    Department of Biochemistry, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, New York 10461, USA
    Biochemistry 42:14258-66. 2003
  7. ncbi Cancer predisposition in mice deficient for the metastasis-associated Mts1(S100A4) gene
    Christina EL Naaman
    Department of Molecular Cancer Biology, Danish Cancer Society, Strandboulevarden 49, DK2100 Copenhagen, Denmark
    Oncogene 23:3670-80. 2004
  8. ncbi The Mts1/S100A4 protein is a neuroprotectant
    Martin V Pedersen
    Protein Laboratory, Institute of Molecular Pathology, University of Copenhagen, Panum Institute 6 2, Copenhagen, Denmark
    J Neurosci Res 77:777-86. 2004
  9. ncbi Metastasis-associated protein S100A4 induces angiogenesis through interaction with Annexin II and accelerated plasmin formation
    Alexandre Semov
    Supratek Pharma Inc, Montreal, Quebec H9S 1A9, Canada
    J Biol Chem 280:20833-41. 2005
  10. pmc Expression of the calcium-binding protein S100A4 is markedly up-regulated by osmotic stress and is involved in the renal osmoadaptive response
    Christopher J Rivard
    Division of Renal Diseases and Hypertension, School of Medicine, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    J Biol Chem 282:6644-52. 2007

Research Grants

  1. Invivo role of S100A4 in OA pathophysiology
    Raghunatha R Yammani; Fiscal Year: 2013
  2. CALCIUM, S100 PROTEINS AND KERATINOCYTE DIFFERENTIATION
    RICHARD ECKERT; Fiscal Year: 2004
  3. The Structure and Function of S100 Proteins
    DAVID JOSEPH WEBER; Fiscal Year: 2010
  4. 600 MHz NMR Spectrometer Console
    David Weber; Fiscal Year: 2007
  5. TGF-beta in Mammary Development and Tumorigenesis
    Harold L Moses; Fiscal Year: 2013
  6. SARAH NICOLE FLIER; Fiscal Year: 2015
  7. Lisa M Curtis; Fiscal Year: 2015
  8. Qiang Ding; Fiscal Year: 2016
  9. Mechanisms of Dendritic Cell Tolerance in Autoimmune Pancreatitis
    CHAD STEPHEN BOOMERSHINE; Fiscal Year: 2010
  10. Heinz Josef Lenz; Fiscal Year: 2016

Detail Information

Publications204 found, 100 shown here

  1. ncbi Isolation of a YAC clone covering a cluster of nine S100 genes on human chromosome 1q21: rationale for a new nomenclature of the S100 calcium-binding protein family
    B W Schafer
    University of Zurich, Department of Pediatrics, Switzerland
    Genomics 25:638-43. 1995
    ..The new nomenclature should facilitate and further the understanding of this protein family and be easily expandable to other species...
  2. ncbi Binding to intracellular targets of the metastasis-inducing protein, S100A4 (p9Ka)
    H Chen
    Molecular Medicine Research Group, University of Liverpool, Liverpool, L69 7ZB, United Kingdom
    Biochem Biophys Res Commun 286:1212-7. 2001
    Experimentally elevated levels of S100A4 induce a metastatic phenotype in benign mammary tumour cells in vivo. In humans, the presence of S100A4 in breast cancer cells correlates strongly with reduced patient survival...
  3. pmc Overexpression of S100A4 in pancreatic ductal adenocarcinomas is associated with poor differentiation and DNA hypomethylation
    Christophe Rosty
    Department of Pathology, The Johns Hopkins Medical Institutions, Baltimore, Maryland 21205 2196, USA
    Am J Pathol 160:45-50. 2002
    Using the National Center for Biotechnology Information Serial Analysis of Gene Expression database, we found that S100A4, a calcium-binding protein previously implicated in metastasis, was expressed in five of seven pancreatic carcinoma ..
  4. pmc S100A4 (p9Ka) protein in colon carcinoma and liver metastases: association with carcinoma cells and T-lymphocytes
    S Taylor
    Cancer Tissue Bank Research Centre, University of Liverpool, P O Box 147, Liverpool, L69 7ZB, UK
    Br J Cancer 86:409-16. 2002
    The presence of the EF-hand-calcium-binding protein S100A4 in the carcinoma cells of the primary tumour is associated with a shorter survival time of a group of breast cancer patients...
  5. ncbi Solution structure of human Mts1 (S100A4) as determined by NMR spectroscopy
    Kristen M Vallely
    Department of Biochemistry and Molecular Biology, University of Maryland School of Medicine, 108 North Greene Street, Baltimore, Maryland 21201, USA
    Biochemistry 41:12670-80. 2002
    b>Mts1 is a member of the S100 family of Ca2+-binding proteins and is implicated in promoting tumor progression and metastasis...
  6. ncbi Mts1 regulates the assembly of nonmuscle myosin-IIA
    Zhong hua Li
    Department of Biochemistry, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, New York 10461, USA
    Biochemistry 42:14258-66. 2003
    ..In contrast, we demonstrate that mts1, a member of the Ca(2+)-regulated S100 family of proteins, may regulate the monomeric, unassembled state in an ..
  7. ncbi Cancer predisposition in mice deficient for the metastasis-associated Mts1(S100A4) gene
    Christina EL Naaman
    Department of Molecular Cancer Biology, Danish Cancer Society, Strandboulevarden 49, DK2100 Copenhagen, Denmark
    Oncogene 23:3670-80. 2004
    Metastasis-promoting Mts1(S100A4) protein belongs to the S100 family of Ca(2+)-binding proteins. A mouse strain with a germ-line inactivation of the S100A4 gene was generated...
  8. ncbi The Mts1/S100A4 protein is a neuroprotectant
    Martin V Pedersen
    Protein Laboratory, Institute of Molecular Pathology, University of Copenhagen, Panum Institute 6 2, Copenhagen, Denmark
    J Neurosci Res 77:777-86. 2004
    Mts1 (S100A4) is a calcium-binding protein of the EF-hand type, belonging to the S100 family of proteins...
  9. ncbi Metastasis-associated protein S100A4 induces angiogenesis through interaction with Annexin II and accelerated plasmin formation
    Alexandre Semov
    Supratek Pharma Inc, Montreal, Quebec H9S 1A9, Canada
    J Biol Chem 280:20833-41. 2005
    Many advanced tumors overexpress and secrete the S100A4 protein that is known to promote angiogenesis and metastasis development. The mechanisms of this effect and the endothelial receptor for S100A4 are both still unknown...
  10. pmc Expression of the calcium-binding protein S100A4 is markedly up-regulated by osmotic stress and is involved in the renal osmoadaptive response
    Christopher J Rivard
    Division of Renal Diseases and Hypertension, School of Medicine, University of Colorado Health Sciences Center, Denver, Colorado 80262, USA
    J Biol Chem 282:6644-52. 2007
    ..Of these proteins, one of the most robustly up-regulated (22-fold) was S100A4. The identity of the protein was verified by high pressure liquid chromatography-mass spectrometry...
  11. pmc Prognostic significance of S100A4 and vascular endothelial growth factor expression in pancreatic cancer
    Kai Xing Ai
    Department of General Surgery, 6th Affiliated Hospital of Shanghai Jiaotong University, Shanghai 200233, China
    World J Gastroenterol 14:1931-5. 2008
    To investigate the expression of vascular endothelial growth factor (VEGF) and calcium-binding protein S100A4 in pancreatic cancer and their relationship to the clinicopathological parameters and prognosis of pancreatic cancer.
  12. doi Crystal structure of the Ca(2+)-form and Ca(2+)-binding kinetics of metastasis-associated protein, S100A4
    Alexandre R Gingras
    Department of Biochemistry, University of Leicester, Henry Wellcome Building, Leicester LE1 9HN, UK
    FEBS Lett 582:1651-6. 2008
    b>S100A4 takes part in control of tumour cell migration and contributes to metastatic spread in in vivo models. In the active dimeric Ca(2+)-bound state it interacts with multiple intracellular targets...
  13. doi Activation of NF-kappaB by extracellular S100A4: analysis of signal transduction mechanisms and identification of target genes
    Kjetil Boye
    Department of Tumor Biology, Rikshospitalet Radiumhospitalet Medical Center, Montebello, N 0310 Oslo, Norway
    Int J Cancer 123:1301-10. 2008
    The metastasis-promoting protein S100A4 stimulates metastatic progression through both intracellular and extracellular functions...
  14. doi Different expression and clinical role of S100A4 in serous ovarian carcinoma at different anatomic sites
    Gunhild M Maelandsmo
    Department of Tumor Biology and Surgery, Norwegian Radium Hospital, Rikshospitalet University Hospital, Oslo, Norway
    Tumour Biol 30:15-25. 2009
    The present study analyzed the site-specific expression and clinical role of S100A4 in advanced-stage ovarian carcinoma (OC)...
  15. ncbi Significance of S100A4 as a prognostic marker of lung squamous cell carcinoma
    Mika Tsuna
    Bioscience Lab, Central Laboratory, Nippon Flour Mills Co, Ltd, Midorigaoka, Atsugi, Kanagawa Japan
    Anticancer Res 29:2547-54. 2009
    The prognostic significance of S100A as potential biomarker for breast cancer was reported; however, this finding has recently been challenged. Here, the aim was to assess whether S100A4 could also be a prognostic biomarker of lung cancer.
  16. pmc S100A4 and metastasis: a small actor playing many roles
    Kjetil Boye
    Department of Tumor Biology, Institute for Cancer Research, The Norwegian Radium Hospital, Oslo University Hospital, N 0310 Oslo, Norway
    Am J Pathol 176:528-35. 2010
    The calcium-binding protein S100A4 promotes metastasis in several experimental animal models, and S100A4 protein expression is associated with patient outcome in a number of tumor types...
  17. pmc Phenothiazines inhibit S100A4 function by inducing protein oligomerization
    Vladimir N Malashkevich
    Department of Biochemistry, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Proc Natl Acad Sci U S A 107:8605-10. 2010
    b>S100A4, a member of the S100 family of Ca(2+)-binding proteins, regulates carcinoma cell motility via interactions with myosin-IIA...
  18. pmc Expression of protein S100A4 is a predictor of recurrence in colorectal cancer
    Jung Myun Kwak
    Department of Surgery, Korea University Guro Hospital, 80 Guro dong, Guro Gu, Seoul, South Korea
    World J Gastroenterol 16:3897-904. 2010
    To investigate the prognostic significance of S100A4 expression in colorectal cancer and its correlation with expression of E-cadherin and p53.
  19. pmc Downregulation of S100A4 expression by RNA interference suppresses cell growth and invasion in human colorectal cancer cells
    Liyong Huang
    Department of Colorectal Surgery, Fudan University Shanghai Cancer Center, Shanghai 200032, PR China
    Oncol Rep 27:917-22. 2012
    b>S100A4 protein, a member of the S100 superfamily of calcium-binding proteins, is frequently observed in various types of human cancers, including colorectal cancer (CRC)...
  20. pmc Asymmetric mode of Ca²⁺-S100A4 interaction with nonmuscle myosin IIA generates nanomolar affinity required for filament remodeling
    Paul R Elliott
    Institute of Integrative Biology, Biosciences Building, Crown Street, University of Liverpool, Liverpool L69 7ZB, UK
    Structure 20:654-66. 2012
    Filament assembly of nonmuscle myosin IIA (NMIIA) is selectively regulated by the small Ca²⁺-binding protein, S100A4, which causes enhanced cell migration and metastasis in certain cancers...
  21. ncbi S100A4 silencing suppresses proliferation, angiogenesis and invasion of thyroid cancer cells through downregulation of MMP-9 and VEGF
    W Jia
    Department of Hepatobiliary and Pancreatic Surgery, Huaxi Hispital Sichuan University, Chengdu, Sichuan, China
    Eur Rev Med Pharmacol Sci 17:1495-508. 2013
    It is well documented that S100A4 is upregulated in many cancers and plays a pivotal role in tumor proliferation, invasion, metastasis and angiogenesis...
  22. pmc Structure of the S100A4/myosin-IIA complex
    Udupi A Ramagopal
    Department of Biochemistry, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, NY 10461, USA
    BMC Struct Biol 13:31. 2013
    b>S100A4, a member of the S100 family of Ca2+-binding proteins, modulates the motility of both non-transformed and cancer cells by regulating the localization and stability of cellular protrusions...
  23. pmc RAGE mediates S100A4-induced cell motility via MAPK/ERK and hypoxia signaling and is a prognostic biomarker for human colorectal cancer metastasis
    Mathias Dahlmann
    Experimental and Clinical Research Center, Charité University Medicine Berlin and Max Delbruck Center for Molecular Medicine, Robert Rössle Straße 10, 13125 Berlin, Germany
    Oncotarget 5:3220-33. 2014
    Survival of colorectal cancer patients is strongly dependent on development of distant metastases. S100A4 is a prognostic biomarker and inducer for colorectal cancer metastasis...
  24. pmc Binding of pEL98 protein, an S100-related calcium-binding protein, to nonmuscle tropomyosin
    K Takenaga
    Division of Chemotherapy, Chiba Cancer Center Research Institute, Japan
    J Cell Biol 124:757-68. 1994
    ..experiment revealed that the 10-kD protein was identical to a calcium-binding protein derived from mRNA named pEL98 or 18A2 that is homologous to S100 protein...
  25. ncbi Effect of Mts1 on the structure and activity of nonmuscle myosin II
    H L Ford
    Department of Biochemistry and Cancer Center, University of Rochester, 601 Elmwood Avenue, Rochester, New York 14642, USA
    Biochemistry 36:16321-7. 1997
    The mts1 gene codes for a 9 kDa protein belonging to the S100 subfamily of Ca2+-binding proteins and is known to play a role in metastasis...
  26. ncbi The dimerization interface of the metastasis-associated protein S100A4 (Mts1): in vivo and in vitro studies
    S Tarabykina
    Department of Molecular Cancer Biology, Danish Cancer Society, Copenhagen DK 2100, Denmark
    J Biol Chem 276:24212-22. 2001
    ..In this study we characterized the dimerization of S100A4 (also named Mts1) in vitro and in vivo...
  27. ncbi Tumor suppressor p53 protein is a new target for the metastasis-associated Mts1/S100A4 protein: functional consequences of their interaction
    M Grigorian
    Department of Molecular Cancer Biology, Institute of Cancer Biology, Danish Cancer Society, Strandboulevarden 49, DK 2100 Copenhagen Ø, Denmark
    J Biol Chem 276:22699-708. 2001
    A physical and functional interaction between the Ca(2+)-binding protein Mts1 (S100A4) and the tumor suppressor p53 protein is shown here for the first time...
  28. ncbi Liprin beta 1, a member of the family of LAR transmembrane tyrosine phosphatase-interacting proteins, is a new target for the metastasis-associated protein S100A4 (Mts1)
    Marina Kriajevska
    Department of Molecular Cancer Biology, Institute of Cancer Biology, Danish Cancer Society, Strandboulevarden 49, DK 2100 Copenhagen Ø, Denmark
    J Biol Chem 277:5229-35. 2002
    Metastasis-associated protein S100A4 (Mts1) induces invasiveness of primary tumors and promotes metastasis...
  29. ncbi Methionine aminopeptidase 2 is a new target for the metastasis-associated protein, S100A4
    Hideya Endo
    Division of Pathology, Department of Cancer Biology, The Institute of Medical Science, The University of Tokyo, 4 6 1 Shirokanedai, Minato ku, Tokyo 108 8639, Japan
    J Biol Chem 277:26396-402. 2002
    b>S100A4 is an EF-hand type calcium-binding protein that regulates tumor metastasis and a variety of cellular processes via interaction with different target proteins...
  30. pmc Expression of S100A4, E-cadherin, alpha- and beta-catenin in breast cancer biopsies
    K B Pedersen
    Department of Tumour Biology, The Norwegian Radium Hospital, Montebello, N 0310 Oslo, Norway
    Br J Cancer 87:1281-6. 2002
    In 66 breast cancer biopsies, the expression of the Ca(2+)-binding protein S100A4, E-cadherin, alpha- and beta-catenin was examined by immunohistochemistry, and the results were related to clinical and pathological parameters...
  31. ncbi Extracellular S100A4 stimulates the migration rate of astrocytic tumor cells by modifying the organization of their actin cytoskeleton
    Nathalie Belot
    Laboratory of Histopathology, Faculty of Medicine, Universite Libre de Bruxelles, Brussels, Belgium
    Biochim Biophys Acta 1600:74-83. 2002
    In previous studies, we have shown that numbers of S100 calcium-binding proteins (including S100A4) are expressed differentially in astrocytic tumors according to their levels of malignancy...
  32. ncbi S100A4 regulates membrane induced activation of matrix metalloproteinase-2 in osteosarcoma cells
    Berit Mathisen
    Department of Biochemistry, Institute of Medical Biology, University of Tromsø, Tromsø, Norway
    Clin Exp Metastasis 20:701-11. 2003
    To study the role of the metastasis associated protein S100A4, an osteosarcoma cell line (OHS) with a high level of this protein was transfected with a vector containing a ribozyme that degrades S100A4 mRNA and, as controls, OHS cells ..
  33. ncbi Interaction of metastasis-inducing S100A4 protein in vivo by fluorescence lifetime imaging microscopy
    Shu Zhang
    Cancer and Polio Research Fund Laboratories, School of Biological Sciences, University of Liverpool, Liverpool, L69 7ZB, UK
    Eur Biophys J 34:19-27. 2005
    Elevated levels of the calcium-binding regulatory protein, S100A4, have been shown to be causative of a metastatic phenotype in models of cancer metastasis and to be associated with reduced patient survival in breast cancer patients...
  34. ncbi Relaxin downregulates the calcium binding protein S100A4 in MDA-MB-231 human breast cancer cells
    Yvonne Radestock
    Department of Human Anatomy and Cell Sciences, University of Manitoba, Faculty of Medicine, 130 Basic Medical Sciences, Winnipeg, MB, R3E 0W3, Canada
    Ann N Y Acad Sci 1041:462-9. 2005
    ..Our investigations revealed downregulation of mRNA and protein of the calcium binding protein S100A4 (metastasin) in MDA-MB-231/pIRES-EGFP-H2 transfectants, indicating a distinct and novel role for relaxin in ..
  35. ncbi S100A4, a mediator of metastasis
    Sarah C Garrett
    Department of Biochemistry, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    J Biol Chem 281:677-80. 2006
  36. pmc S100A4 (Mts1) gene overexpression is associated with invasion and metastasis of papillary thyroid carcinoma
    M Zou
    Department of Genetics, King Faisal Specialist Hospital and Research Center, PO Box 3354, Riyadh 11211, Saudi Arabia
    Br J Cancer 93:1277-84. 2005
    Tumour cell invasion and metastasis are the hallmark of malignant neoplasm. S100A4 is a member of small calcium-binding protein family and is involved in the cell proliferation and cancer progression...
  37. ncbi Association of S100A4 and osteopontin with specific prognostic factors and survival of patients with minimally invasive breast cancer
    Suzete De Silva Rudland
    Cancer and Polio Research Fund Laboratories, School of Biological Sciences, Royal Liverpool University Hospital, UK
    Clin Cancer Res 12:1192-200. 2006
    b>S100A4 and the estrogen-inducible osteopontin are alone capable of inducing angiogenesis and metastasis in rodent models for breast cancer...
  38. ncbi Increase in production of matrix metalloproteinase 13 by human articular chondrocytes due to stimulation with S100A4: Role of the receptor for advanced glycation end products
    Raghunatha R Yammani
    Wake Forest University School of Medicine, Winston Salem, North Carolina 27157, USA
    Arthritis Rheum 54:2901-11. 2006
    ..The aims of this study were to determine whether chondrocytes produce S100A4 and whether S100A4 can stimulate the production of matrix metalloproteinase 13 (MMP-13) by articular chondrocytes ..
  39. pmc S100A4 accelerates tumorigenesis and invasion of human prostate cancer through the transcriptional regulation of matrix metalloproteinase 9
    Mohammad Saleem
    Department of Dermatology, University of Wisconsin, Madison, WI 53706, USA
    Proc Natl Acad Sci U S A 103:14825-30. 2006
    We previously showed that the calcium-binding protein S100A4 is overexpressed during the progression of prostate cancer (CaP) in humans and in the TRAMP (transgenic adenocarcinoma of the mouse prostate) mouse model...
  40. ncbi Modified expression of Mts1/S100A4 protein in C6 glioma cells or surrounding astrocytes affects migration of tumor cells in vitro and in vivo
    Keizo Takenaga
    Department of Neuroscience, Biomedical Center, Box 587, Uppsala University, 751 23 Uppsala, Sweden
    Neurobiol Dis 25:455-63. 2007
    The calcium-binding Mts1/S100A4 protein plays an important role in motility and metastatic activity of tumor cells...
  41. ncbi Up-regulation of metastasis-promoting S100A4 (Mts-1) in rheumatoid arthritis: putative involvement in the pathogenesis of rheumatoid arthritis
    Jorg Klingelhofer
    Danish Cancer Society, Copenhagen, Denmark
    Arthritis Rheum 56:779-89. 2007
    To examine the involvement of the metastasis-inducing protein S100A4 (Mts-1) in the pathogenesis of rheumatoid arthritis (RA).
  42. ncbi Metastasis-associated protein S100A4: spotlight on its role in cell migration
    S Tarabykina
    Novo Nordisk A S, Maaloev, Denmark
    Curr Cancer Drug Targets 7:217-28. 2007
    b>S100A4 (also known as Mts1, metastasin, p9Ka, pEL98, CAPL, calvasculin, Fsp-1, placental calcium-binding protein) belongs to the family of EF-hand calcium-binding proteins, whose expression is elevated in a number of pathological ..
  43. ncbi Expression of S100A4 by a variety of cell types present in the tumor microenvironment of human breast cancer
    Teresa Cabezon
    Department of Proteomics in Cancer, Institute of Cancer Biology, Danish Cancer Society, Copenhagen, Denmark
    Int J Cancer 121:1433-44. 2007
    The S100A4 protein, which is involved in the metastasis process, is a member of the S100 superfamily of Ca-binding proteins...
  44. ncbi S100A4 contributes to the suppression of BNIP3 expression, chemoresistance, and inhibition of apoptosis in pancreatic cancer
    Patrick C Mahon
    Centre for Molecular Oncology, Institute of Cancer and the Cancer Research UK Clinical Centre, Barts and the London School of Medicine, London, United Kingdom
    Cancer Res 67:6786-95. 2007
    ..This analysis identified several S100 family proteins, of which two, S100A2 and S100A4, showed in vitro the ability to repress exogenous BNIP3 promoter activity...
  45. pmc A biosensor of S100A4 metastasis factor activation: inhibitor screening and cellular activation dynamics
    Sarah C Garrett
    Department of Biochemistry, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, New York 10461, USA
    Biochemistry 47:986-96. 2008
    b>S100A4, a member of the S100 family of Ca2+-binding proteins, displays elevated expression in malignant human tumors compared with benign tumors, and increased expression correlates strongly with poor patient survival...
  46. pmc Structure of Ca2+-bound S100A4 and its interaction with peptides derived from nonmuscle myosin-IIA
    Vladimir N Malashkevich
    Department of Biochemistry, Albert Einstein College of Medicine, 1300 Morris Park Avenue, Bronx, New York 10461, USA
    Biochemistry 47:5111-26. 2008
    b>S100A4, also known as mts1, is a member of the S100 family of Ca2+-binding proteins that is directly involved in tumor invasion and metastasis via interactions with specific protein targets, including nonmuscle myosin-IIA (MIIA)...
  47. pmc Crystal structure of metastasis-associated protein S100A4 in the active calcium-bound form
    Puja Pathuri
    Department of Molecular Biology and Biochemistry, University of California, Irvine, CA 92697, USA
    J Mol Biol 383:62-77. 2008
    b>S100A4 (metastasin) is a member of the S100 family of calcium-binding proteins that is directly involved in tumorigenesis...
  48. doi The basic C-terminal amino acids of calcium-binding protein S100A4 promote metastasis
    Thamir M Ismail
    Cancer and Polio Research Fund Laboratories, Biosciences Building, University of Liverpool, Liverpool, UK
    Carcinogenesis 29:2259-66. 2008
    The calcium-binding protein S100A4 can induce a metastatic phenotype in animal model systems and its expression in various human cancers has been shown to be associated with metastasis and reduced patient survival...
  49. pmc Integrin alpha6beta4 controls the expression of genes associated with cell motility, invasion, and metastasis, including S100A4/metastasin
    Min Chen
    Department of Surgery, University of Texas Medical Branch, Galveston, Texas 77555, USA
    J Biol Chem 284:1484-94. 2009
    ..01). Of these genes, 36 are associated with pathways implicated in cell motility and metastasis, including S100A4/metastasin. S100A4 expression correlated well with integrin alpha6beta4 expression in established cell lines...
  50. doi Metastasis promoter S100A4 is a potentially valuable molecular target for cancer therapy
    G V Sherbet
    School of Electrical, Electronic and Computer Engineering, University of Newcastle, Newcastle upon Tyne NE1 7RU, UK
    Cancer Lett 280:15-30. 2009
    ..Several genetic determinants relating to proliferation and growth, invasion and metastasis have been identified. S100A4 appears to be able to activate and integrate pathways to generate the phenotypic responses that are characteristic ..
  51. doi S100A4 mRNA is a diagnostic and prognostic marker in pancreatic carcinoma
    Naoki Ikenaga
    Department of Surgery and Oncology, Graduate School of Medical Sciences, Kyushu University, 3 1 1 Maidashi, Fukuoka, 812 8582, Japan
    J Gastrointest Surg 13:1852-8. 2009
    The aim of this study is to evaluate the clinical significance of S100A4 mRNA expression in pancreatic cancer.
  52. doi Epidermal growth factor receptor ligands as new extracellular targets for the metastasis-promoting S100A4 protein
    Jorg Klingelhofer
    Department of Molecular Cancer Biology, Institute of Cancer Biology, Danish Cancer Society, Copenhagen, Denmark
    FEBS J 276:5936-48. 2009
    The function of S100A4, a member of the calcium-binding S100 protein family, has been associated with tumor invasion and metastasis...
  53. doi RNA interference targeting against S100A4 suppresses cell growth and motility and induces apoptosis in human pancreatic cancer cells
    Takahiro Tabata
    Department of Molecular Pathology, Tohoku University School of Medicine, Sendai, Miyagi 980 8575, Japan
    Biochem Biophys Res Commun 390:475-80. 2009
    b>S100A4 protein belongs to the S100 subfamily, which has grown to be one of the large subfamilies of the EF-hand Ca(2+)-binding proteins, and overexpression of S100A4 is suggested to associate with cell proliferation, invasion, and ..
  54. doi High-level expression of S100A4 correlates with lymph node metastasis and poor prognosis in patients with gastric cancer
    Yuan Yu Wang
    Wenzhou Medical College, Wenzhou, Zhejiang, People s Republic of China
    Ann Surg Oncol 17:89-97. 2010
    ..The present study investigated the clinical significance of S100 calcium binding protein A4 in the development, progression, and metastasis of gastric cancer...
  55. pmc Self-association of calcium-binding protein S100A4 and metastasis
    Thamir M Ismail
    School of Biological Sciences, University of Liverpool, Liverpool L69 7ZB, United Kingdom
    J Biol Chem 285:914-22. 2010
    Elevated levels of the calcium-binding protein S100A4 promote metastasis and in carcinoma cells are associated with reduced survival of cancer patients...
  56. doi Short hairpin RNA-mediated inhibition of S100A4 promotes apoptosis and suppresses proliferation of BGC823 gastric cancer cells in vitro and in vivo
    Jun Hua
    Department of Medical Genetics, China Medical University, Shenyang, Liaoning, China
    Cancer Lett 292:41-7. 2010
    b>S100A4 has been found to be over-expressed in gastric cancer and associated with poor prognosis of the patients, yet the exact role and molecular mechanism of S100A4 in gastric cancer has not been determined...
  57. ncbi Expression status of S100A14 and S100A4 correlates with metastatic potential and clinical outcome in colorectal cancer after surgery
    Hong Yi Wang
    Department of Surgery, Key laboratory of Carcinogenesis and Translational Research, Peking University School of Oncology, Beijing Cancer Hospital and Institute, Beijing, P R China
    Oncol Rep 23:45-52. 2010
    To investigate whether S100A14 and S100A4 expression correlates with metastatic potential and prognosis in colorectal cancer (CRC), we firstly used RT-PCR analysis to detect mRNA expression of S100A14 and S100A4 in 40 pairs of fresh tumor ..
  58. pmc Overexpression of S100A4 in human cancer cell lines resistant to methotrexate
    Núria Mencia
    Department of Biochemistry and Molecular Biology, School of Pharmacy, University of Barcelona, Barcelona, Spain
    BMC Cancer 10:250. 2010
    ..Combination treatments of MTX with other drugs that could modulate the expression of genes involved in MTX resistance would be an adequate strategy to prevent the development of this resistance...
  59. doi Nuclear S100A4 is a novel prognostic marker in colorectal cancer
    Kjetil Boye
    Department of Tumor Biology, Institute for Cancer Research, The Norwegian Radium Hospital, Oslo University Hospital, Oslo, Norway
    Eur J Cancer 46:2919-25. 2010
    ..b>S100A4 is a Ca(2+)-binding protein which promotes metastasis in several tumour types, and the aim of the present study ..
  60. doi Small interfering RNA-directed knockdown of S100A4 decreases proliferation and invasiveness of osteosarcoma cells
    Xu Ma
    Department of Orthopaedics, The First Affiliated Hospital, China Medical University, Shenyang 110001, Liaoning Province, PR China
    Cancer Lett 299:171-81. 2010
    ..b>S100A4 has been implicated in the proliferation, cell cycle progression, and metastasis of many malignant tumors, ..
  61. pmc Mechanism of the Ca²+-dependent interaction between S100A4 and tail fragments of nonmuscle myosin heavy chain IIA
    Sandip K Badyal
    Department of Biochemistry, University of Leicester, Henry Wellcome Building, Lancaster Road, Leicester LE1 9HN, UK
    J Mol Biol 405:1004-26. 2011
    The interaction between the calcium-binding protein S100A4 and the C-terminal fragments of nonmuscle myosin heavy chain IIA has been studied by equilibrium and kinetic methods...
  62. doi The epithelial-mesenchymal transition mediator S100A4 maintains cancer-initiating cells in head and neck cancers
    Jeng Fan Lo
    Institute of Oral Biology, National Yang Ming University, Taipei, Taiwan, ROC
    Cancer Res 71:1912-23. 2011
    ..HN-CIC), we determined as a candidate stemness-maintaining molecule for HN-CICs the proinflammatory mediator S100A4, which is also known to be an inducer of epithelial-mesenchymal transition...
  63. pmc S100A4 over-expression underlies lymph node metastasis and poor prognosis in colorectal cancer
    Li Yong Huang
    Department of Colorectal Surgery, Fudan University Shanghai Cancer Center, Shanghai 200032, China
    World J Gastroenterol 17:69-78. 2011
    ..To develop lymph node metastasis (LNM)-associated biomarkers for colorectal cancer (CRC) using quantitative proteome analysis...
  64. doi Stable knockdown of S100A4 suppresses cell migration and metastasis of osteosarcoma
    Masahiko Fujiwara
    Department of Human Pathology, Graduate School of Medicine, University of Tokyo, Tokyo, Japan
    Tumour Biol 32:611-22. 2011
    b>S100A4, a 10-12 kDa calcium-binding protein, plays functional roles in tumor progression and metastasis. The present study aimed to investigate the function of S100A4 in osteosarcoma (OS) metastasis, using a loss-of-function approach...
  65. pmc Nuclear expression of S100A4 calcium-binding protein increases cholangiocarcinoma invasiveness and metastasization
    Luca Fabris
    Department of Surgical and Gastroenterological Sciences, University of Padova, Italy
    Hepatology 54:890-9. 2011
    ..The mechanisms responsible for CCA invasiveness are unclear. S100A4, a member of the S100 family of small Ca(2+)-binding proteins, is expressed in mesenchymal cells, regulates cell ..
  66. pmc Two functional S100A4 monomers are necessary for regulating nonmuscle myosin-IIA and HCT116 cell invasion
    Reniqua P House
    Department of Biochemistry, Albert Einstein College of Medicine, Bronx, New York 10461, United States
    Biochemistry 50:6920-32. 2011
    b>S100A4, a member of the Ca(2+)-activated S100 protein family, regulates the motility and invasiveness of cancer cells. Moreover, high S100A4 expression levels correlate with poor patient survival in several cancers...
  67. doi Prognostic significance of S100A4 mRNA and protein expression in colorectal cancer
    Yoon Goo Kang
    Department of Hospital Pathology, College of Medicine, The Catholic University of Korea, Seoul, Republic of Korea
    J Surg Oncol 105:119-24. 2012
    The calcium-binding protein S100A4 promotes tumor progression and metastasis. We investigated the expression of S100A4 in colorectal cancer and its clinicopathologic significance in colorectal cancer.
  68. pmc S100A4 silencing blocks invasive ability of esophageal squamous cell carcinoma cells
    Dong Chen
    Department of Surgery, The Affiliated Hospital of Qingdao Medical College, Qingdao University, Qingdao 266003, Shandong Province, China
    World J Gastroenterol 18:915-22. 2012
    To investigate a potential role of S100A4 in esophagus squamous cell carcinoma metastasis (ESCCs).
  69. doi S100A4 regulates motility and invasiveness of human esophageal squamous cell carcinoma through modulating the AKT/Slug signal pathway
    K Zhang
    General Surgery, Affiliated Hospital of Medical College, Qingdao University, Qingdao, Shan Dong Province, China
    Dis Esophagus 25:731-9. 2012
    The involvement of S100A4 in modulating invasiveness of esophageal squamous cell carcinoma (ESCC) cell lines was explored. It was shown that S100A4 expression is positively correlated with the degree of invasiveness in human ESCC cells...
  70. ncbi Evaluation of plasma and tissue S100A4 protein and mRNA levels as potential markers of metastasis and prognosis in clear cell renal cell carcinoma
    H Yang
    Department of Nephrology, The Second Hospital of Tianjin Medical University, Tianjin, China
    J Int Med Res 40:475-85. 2012
    To investigate levels of S100A4 protein in plasma and S100A4 mRNA in tumours from patients with clear cell renal cell carcinoma (CCRCC), and correlate these with metastasis, survival and levels of vascular endothelial growth factor (VEGF).
  71. pmc Systemic shRNA mediated knock down of S100A4 in colorectal cancer xenografted mice reduces metastasis formation
    Mathias Dahlmann
    Experimental and Clinical Research Center, joint cooperation between Charité, Medical Faculty and Max Delbrück Center for Molecular Medicine, Berlin, Germany
    Oncotarget 3:783-97. 2012
    The metastasis-inducing protein S100A4 was found to be a prognostic indicator for the development of metachronous metastases...
  72. doi S100A4 siRNA inhibits human pancreatic cancer cell invasion in vitro
    Na Li
    Department of General Surgery, Beijing Tiantan Hospital, Capital Medical University, Beijing 100050, China
    Biomed Environ Sci 25:465-70. 2012
    Pancreatic cancer is one of the most deadly cancers, which is characterized by its high metastatic potential. S100A4 is a major prometastatic protein involved in tumor invasion and metastasis which precise role in pancreatic cancer has ..
  73. doi S100A4, frequently overexpressed in various human cancers, accelerates cell motility in pancreatic cancer cells
    Hitoshi Sekine
    Department of Molecular Pathology, Tohoku University School of Medicine, Sendai, Miyagi 980 8575, Japan
    Biochem Biophys Res Commun 429:214-9. 2012
    b>S100A4, a member of the Ca(2+) dependent S100 protein family, is reported to associate with metastasis through regulation of the motility and invasiveness of cancer cells...
  74. ncbi S100A4 promotes invasion and angiogenesis in breast cancer MDA-MB-231 cells by upregulating matrix metalloproteinase-13
    Lin Wang
    Department of Breast and Thyroid Diseases, Tianjin Union Medicine Centre, Tianjin, China
    Acta Biochim Pol 59:593-8. 2012
    b>S100A4 is a member of the S100 family of calcium-binding proteins that is directly involved in tumor metastasis...
  75. pmc Elevation of S100A4 expression in buccal mucosal fibroblasts by arecoline: involvement in the pathogenesis of oral submucous fibrosis
    Cheng Chia Yu
    Institute of Oral Science, Chung Shan Medical University, Taichung, Taiwan
    PLoS ONE 8:e55122. 2013
    b>S100A4, a member of the calcium-binding proteins, is dramatically elevated in a variety of fibrotic diseases. Areca quid chewing is the most important etiological factor in the pathogenesis of oral submucous fibrosis (OSF)...
  76. pmc Silencing of S100A4, a metastasis-associated protein, in endothelial cells inhibits tumor angiogenesis and growth
    Takahiro Ochiya
    Division of Molecular and Cellular Medicine, National Cancer Center Research Institute, 5 1 1, Tsukiji, Chuo Ku, Tokyo, 104 0045, Japan
    Angiogenesis 17:17-26. 2014
    Endothelial cells express S100A4, a metastasis-associated protein, but its role in angiogenesis remains to be elucidated...
  77. ncbi S100A4 regulates migration and invasion in hepatocellular carcinoma HepG2 cells via NF-κB-dependent MMP-9 signal
    J Zhang
    Department of Surgery, the Affiliated Hospital of Medical College, Qingdao University, Qingdao, China
    Eur Rev Med Pharmacol Sci 17:2372-82. 2013
    We previously showed that the calcium-binding protein S100A4 is overexpressed and related to metastasis in hepatocellular carcinoma (HCC)...
  78. ncbi Correlation between expression of S100A4 and VEGF-C, and lymph node metastasis and prognosis in gastric carcinoma
    L Z Feng
    Department of Surgery, The Second Hospital of Jiaxing City, Jiaxing, Zhejiang Province, China
    J Int Med Res 39:1333-43. 2011
    This semiquantitative immunohistochemical study investigated the clinical significance of S100A4 and vascular endothelial growth factor C (VEGF-C) protein expression in gastric carcinoma...
  79. pmc S100A4 mediates endometrial cancer invasion and is a target of TGF-beta1 signaling
    Ran Xie
    Department of Pathology, University of Texas M D Anderson Cancer Center, Houston, TX, USA
    Lab Invest 89:937-47. 2009
    The molecular mechanisms of endometrial cancer invasion are poorly understood. S100A4, also known as FSP1 (fibroblast-specific protein 1), has long been known to be a molecular marker of fibrosis in a variety of different fibrotic ..
  80. ncbi Effects of E-cadherin transfection on gene expression of a gallbladder carcinoma cell line: repression of MTS1/S100A4 gene expression
    Naohiko Kohya
    Department of Surgery, Saga Medical School, Saga, Japan
    Int J Cancer 104:44-53. 2003
    ..Conventional RT-PCR revealed that E-cadherin transfection suppressed expression of mts1 mRNA and increased that of c-myc and MT1-MMP...
  81. ncbi Microarray analysis of metastasis-associated gene expression profiling in a murine model of thyroid carcinoma pulmonary metastasis: identification of S100A4 (Mts1) gene overexpression as a poor prognostic marker for thyroid carcinoma
    Minjing Zou
    Department of Genetics, King Faisal Specialist Hospital and Research Centre, Riyadh 11211, Saudi Arabia
    J Clin Endocrinol Metab 89:6146-54. 2004
    ..to tumor progression were identified, such as c-Met, ezrin, integrin, motility-related protein-1, cadherin, and S100A4. The most highly expressed gene is the S100A4 (8-fold higher than control), which is a member of a small calcium ..
  82. ncbi Mutually antagonistic actions of S100A4 and S100A1 on normal and metastatic phenotypes
    Guozheng Wang
    School of Biological Sciences, University of Liverpool, Crown Street, Liverpool L69 7ZB, UK
    Oncogene 24:1445-54. 2005
    Increased levels of the homodimeric calcium-binding protein, S100A4, have been shown to cause a metastatic phenotype in at least three independent model systems of breast cancer and its presence in carcinoma cells has been shown to be ..
  83. ncbi S100A4 expression is an early event of papillary carcinoma of the thyroid
    Yasuhiro Ito
    Kuma Hospital, Kobe, Japan
    Oncology 67:397-402. 2004
    b>S100A4 is a calcium-binding protein related to the metastatic potential of carcinoma. In order to elucidate its contribution to the progression of thyroid carcinoma, we investigated S100A4 expression in various thyroid neoplasms.
  84. ncbi Hypomethylation-induced expression of S100A4 in endometrial carcinoma
    Ran Xie
    Department of Pathology, University of Texas MD Anderson Cancer Center, Houston, TX 77030 4095, USA
    Mod Pathol 20:1045-54. 2007
    ..We hypothesized that S100A4 would be overexpressed in endometrial carcinoma compared to benign endometrium...
  85. doi Functional interaction between Smad3 and S100A4 (metastatin-1) for TGF-beta-mediated cancer cell invasiveness
    Isao Matsuura
    Division of Molecular and Genomic Medicine, National Health Research Institutes, 35 Keyan Road, Zhunan, Miaoli County 35053, Taiwan
    Biochem J 426:327-35. 2010
    ..In the present study, we show that S100A4, a metastasis-associated protein, also called metastatin-1, can physically and functionally interact with Smad3, ..
  86. pmc A role for CCN3 (NOV) in calcium signalling
    C L Li
    Laboratoire d Oncologie Virale et Moléculaire LOVM, UFR de Biochimie, Université Paris 7 D Diderot, 2 place Jussieu, 75005 Paris, France
    Mol Pathol 55:250-61. 2002
    ....
  87. ncbi Characterization of the metastasis-associated protein, S100A4. Roles of calcium binding and dimerization in cellular localization and interaction with myosin
    Edward J Kim
    Cold Spring Harbor Laboratory, Cold Spring Harbor, New York 11724, USA
    J Biol Chem 278:30063-73. 2003
    Elevated S100A4 protein expression is associated with metastatic tumor progression and appears to be a strong molecular marker for clinical prognosis...
  88. pmc Calcium-binding S100 protein expression in pterygium
    Andri K Riau
    Singapore Eye Research Institute, Singapore
    Mol Vis 15:335-42. 2009
    ..The aim of this study was to investigate the presence of various S100 proteins in pterygium compared to normal conjunctiva...
  89. doi TD-11 workshop report: characterization of monoclonal antibodies to S100 proteins
    Elisabeth Paus
    Department of Medical Biochemistry, Oslo University Hospital, Oslo, Norway
    Tumour Biol 32:1-12. 2011
    ..The mimotopes of antibodies against S100A4 were determined by random peptide phage display libraries...
  90. ncbi RAGE: a single receptor for several ligands and different cellular responses: the case of certain S100 proteins
    Rosario Donato
    Department of Experimental Medicine and Biochemical Sciences, University of Perugia, Via del Giochetto, 06122 Perugia, Italy
    Curr Mol Med 7:711-24. 2007
    ..receptor for advanced glycation end products (RAGE) has been shown to transduce extracellular effects of S100B, S100A4, S100A6, S100A11, S100A12, S100A13 and S100P...
  91. ncbi Immunohistochemical localization of the Ca2+ binding S100 proteins in normal human skin and melanocytic lesions
    R Boni
    Department of Dermatology, University of Zurich, Switzerland
    Br J Dermatol 137:39-43. 1997
    ..The purpose of this study was to evaluate the expression of the Ca(2+)-binding S100 proteins S100A1, S100A2, S100A3, S100A4, S100A6 and S100B in normal skin...
  92. ncbi Development and progression of malignancy in human colon tissues are correlated with expression of specific Ca(2+)-binding S100 proteins
    Y Bronckart
    Laboratory of Histopathology, Faculty of Medicine, Free University of Brussels, Belgium
    Histol Histopathol 16:707-12. 2001
    The expression levels of seven different S100 proteins (S100A1, S100A2, S100A3, S100A4, S100A5, S100A6, and S100B) were characterized by immunohistochemistry in the epithelial versus connective tissues of a series of 35 colon specimens, ..
  93. doi Direct inhibitory and indirect stimulatory effects of RAGE ligand S100 on sRANKL-induced osteoclastogenesis
    Tomohiko Yoshida
    Department of Molecular Pharmacology and Biological Chemistry, Northwestern University Feinberg School of Medicine, Chicago, Illinois 60611, USA
    J Cell Biochem 107:917-25. 2009
    ..S100 proteins are ligands for the receptor of AGEs (RAGE). An intracellular role of the S100 family member S100A4 (Mts1) to suppress mineralization has been described in pre-osteoblastic MC3T3-E1 cells...
  94. doi 15N relaxation studies of Apo-Mts1: a dynamic S100 protein
    Kaushik Dutta
    New York Structural Biology Center, 89 Convent Avenue, New York, New York 10033, USA
    Biochemistry 47:7637-47. 2008
    b>Mts1 is a member of the S100 family of EF-hand calcium-binding proteins...
  95. ncbi The mitochondrial protein targeting suppressor (mts1) mutation maps to the mRNA-binding domain of Npl3p and affects translation on cytoplasmic polysomes
    S Gratzer
    Department of Biochemistry, La Trobe University, Bundoora 3083, Australia
    Mol Microbiol 35:1277-85. 2000
    ..As a result, defects in nascent polypeptide targeting to subcellular compartments such as the mitochondria are also suppressed...
  96. ncbi Immunolocalization of fibroblast growth factor-1 (FGF-1), its receptor (FGFR-1), and fibroblast-specific protein-1 (FSP-1) in inflammatory renal disease
    Michele Rossini
    Department of Pathology, Vanderbilt University Medical Center, Nashville, TN 37232, USA
    Kidney Int 68:2621-8. 2005
    ....
  97. ncbi The Saccharomyces cerevisiae MTS1 gene encodes a putative RNA-binding protein involved in mitochondrial protein targeting
    E M Ellis
    Institute of Cell and Molecular Biology, University of Edinburgh, Scotland, UK
    Gene 132:175-83. 1993
    ..Two yeast mutants (mts1 and mts2) were isolated as extragenic suppressors of a known targeting defect in the presequence of the beta-..
  98. ncbi cDNA cloning of S100 calcium-binding proteins from bovine periodontal ligament and their expression in oral tissues
    W R Duarte
    Department of Periodontology, Faculty of Dentistry, Tokyo Medical and Dental University, Japan
    J Dent Res 77:1694-9. 1998
    ..We screened the PDL cDNA library with a mouse S100A4 cDNA, and cloned the bovine cDNAs of two S100 CaBPs (S100A4 and S100A2)...
  99. ncbi Role of basic fibroblast growth factor-2 in epithelial-mesenchymal transformation
    Frank Strutz
    Department of Nephrology and Rheumatology, Georg August University Medical Center, Gottingen, Germany
    Kidney Int 61:1714-28. 2002
    ....
  100. ncbi Effects of sulfasalazine and a sulfasalazine analogue on the formation of lipoxygenase and cyclooxygenase products
    S Tornhamre
    Department of Physiological Chemistry, Karolinska Institutet, Stockholm, Sweden
    Eur J Pharmacol 169:225-34. 1989
    A sulfasalazine analogue, 5'-(2,4-dichlorobenzoyl)2'-hydroxyphenylacetic acid (CL 42A), potently inhibited the formation of 5-lipoxygenase products (leukotrienes B4 and C4 and 5-hydroxyeicosatetraenoic acid) by human leukocytes...
  101. ncbi Expression of members of the S100 Ca2+-binding protein family in guinea-pig smooth muscle
    B Daub
    Department of Physiology, University of Cologne, Robert Koch Strasse 39, 50931 Cologne, Germany
    Cell Calcium 33:1-10. 2003
    ..Transcripts of cDNA of S100A1, S100A4, S100A6 and S100A10 were amplified from smooth muscle RNA of neonatal and adult urinary bladder, ileum, aorta and ..

Research Grants40

  1. Invivo role of S100A4 in OA pathophysiology
    Raghunatha R Yammani; Fiscal Year: 2013
    ..The purpose is to obtain pilot data on the role of S100A4 in the development of osteoarthritis...
  2. CALCIUM, S100 PROTEINS AND KERATINOCYTE DIFFERENTIATION
    RICHARD ECKERT; Fiscal Year: 2004
    ..Specific Aim 1, they clone, express, and generate antibodies to the remaining keratinocyte S100 proteins, S100A2, S100A4, S100A6, S100A8, and S100A9...
  3. The Structure and Function of S100 Proteins
    DAVID JOSEPH WEBER; Fiscal Year: 2010
    ..e. for S100A1, S100A2, and S100A4) will identify the molecular determinants that provide specificity in S100-target protein complexes;and (3) we ..
  4. 600 MHz NMR Spectrometer Console
    David Weber; Fiscal Year: 2007
    ..Dr. James Nataro, Structure/Function studies of Dispersin; 8. Dr. Kristen Varney, Structure and Function of Mts1 (S100A4)...
  5. TGF-beta in Mammary Development and Tumorigenesis
    Harold L Moses; Fiscal Year: 2013
    ..By conditional knockout of the type II TGFss receptor gene (Tgfbr2) in a subset of tissue fibroblasts using FSP1-Cre (Tgfbr2FSPKO), we have shown that loss of TGF-ss signaling enhances the initiation and progression of ..
  6. SARAH NICOLE FLIER; Fiscal Year: 2015
    ..Although fibroblasts are considered a heterogeneous population, those that express fibroblast-specific protein 1 (FSP1) or 1-smooth muscle actin (1SMA) have been most extensively studied in the context of fibrosis...
  7. Lisa M Curtis; Fiscal Year: 2015
    ..The overall hypothesis of the proposal is that renal reparative cells reside in the Fsp1+ cell population of the renal papilla and are recruited to sites of injury in response to the specific factors, HGF ..
  8. Qiang Ding; Fiscal Year: 2016
    ..Increased S100A4 expression is associated with increased lung fibrosis in FRNK deficient mice...
  9. Mechanisms of Dendritic Cell Tolerance in Autoimmune Pancreatitis
    CHAD STEPHEN BOOMERSHINE; Fiscal Year: 2010
    ..in transgenic mice lacking the ability to respond to transforming growth factor [unreadable] (TGF[unreadable]) in S100A4 expressing cells...
  10. Heinz Josef Lenz; Fiscal Year: 2016
    ..in regulating the expression of Wnt/[unreadable]-catenin regulated genes including survivin, EGFR, VEGF, EphB2, S100A4,CD44, connexin 43 and cyclin D1, which play important roles in initiation, proliferation, angiogenesis, metastasis ..
  11. Shideng Bao; Fiscal Year: 2014
    ..of GBM stem cells, and decreases expression of three invasion-associated proteins (RhoC, Cathepsin L2 and S100A4/Metastasin), suggesting that L1CAM plays a crucial role in mediating GBM stem cell invasion, and L1CAM may ..
  12. Assembly and disassembly of the stromal architecture in the tumor microenvironmen
    Frank C Marini; Fiscal Year: 2010
    ..Tie2 promoter), GFP-labeled myeloid progenitors (cFMS-promoter), YFP-bone marrow fibroblasts/mesenchyme (FSP1-promoter) known to participate in tumor stroma formation...
  13. High Resolution Ultrasound Biomicroscopy System
    Daniel Bernstein; Fiscal Year: 2005
    ..the apelin/APJ-receptor, microtubule-associated protein light chain 3 (LC3), the calcium binding protein S100A4/Mtsl, and bone morphogenetic protein receptors (BMP-R) I and II...
  14. MOLECULAR CLONING OF FAMILIAL SPASTIC PARAPLEGIA
    Eric Hoffman; Fiscal Year: 1999
    ..There is genetic heterogeneity in autosomal FSP, with autosomal dominant loci at 14q, 2p, and 15q (FSP1, FSP2, and FSP3 respectively) and an autosomal recessive locus at 8q...
  15. DNA MUTATION BIOMARKERS FOR NONMELANOMA SKIN CANCER
    James Gale; Fiscal Year: 2000
    ..measure UVR-specific mutations in critical oncogenes or tumor suppressor genes linked to skin cancers (ras, p53, MTS1, etc...
  16. MOLECULAR MECHANISMS OF RENAL FIBROSIS
    ERIC NEILSON; Fiscal Year: 2007
    ..study and better understand their role, we recently discovered a new protein called fibroblast-specific protein-I (FSP1)...
  17. REGULATION OF MEIOTIC DEVELOPMENT BY MTS1-MTS2 PROTEIN
    WAYNE WAHLS; Fiscal Year: 2004
    ..Dr. Wahls and colleagues purified a heterodimeric protein, Mts1-Mts2-M26 complex serves as an enhancer of recombination...
  18. REGULATION OF SIC1 INHIBITION OF YEAST CDK COMPLEXES
    MICHAEL MENDENHALL; Fiscal Year: 1999
    ..Other proteins with Cdk inhibitory activity include a potent tumor suppressor (MTS1/INK4) and a key target of the p53 tumor suppressor (CIP1/WAF1)...
  19. P16 AND CELL SENESCENCE AND ONCOGENESIS
    Manuel Diaz; Fiscal Year: 2001
    DESCRIPTION: (Applicant's Abstract) The tumor suppressor gene INK4A (MTS1, CDK41, CDKN2) codes for p16, an inhibitor of the G1 cyclin-dependent kinases CDK4 and CDK6...
  20. Combinatoial CREB/ATF dimers and cellular growth control
    WAYNE WAHLS; Fiscal Year: 2004
    ..Aim 3, To further characterize regulatory mechanisms for stress responses mediated by the Mts1 bZIP protein: elucidate the role of the MAP kinase Spcl in controlling an autoinhibitory function of Mts1...
  21. Fibroblast Specific Protein 1 in Pulmonary Fibrosis
    TIMOTHY BLACKWELL; Fiscal Year: 2004
    ..b>Fibroblast specific protein 1 (FSP1) is a member of the S100 protein superfamily and appears to play an early role in establishing ..
  22. Novel Mechanisms of Myosin-II Mediated Motility
    Anne Bresnick; Fiscal Year: 2007
    ..Several proteins have been shown to stabilize filamentous myosin-II assemblies; however mts1, a member of the Ca2+regulated S100 family of proteins, is the first protein to be identified that promotes the ..
  23. ISOLATION CHROMOSOME 17Q25 GENE INVOLED IN BREAST CANCER
    ELIZABETH PETTY; Fiscal Year: 1999
    ..Other genes, including TP53 and MTS1, have demonstrated involvement in breast carcinogenesis...
  24. TGF BETA EXPRESSION FOLLOWING ISCHEMIC ACUTE RENAL FAIL
    DAVID BASILE; Fiscal Year: 2002
    ..abstract_text> ..
  25. Immunological Secretomes of the Early Anthrax Infection
    Chun Ming Huang; Fiscal Year: 2010
    ..This protein will thus serve as a positive control to evaluate novel antigens identified in the proposed studies. ..
  26. Pathology of the FSGS Kidney
    Agnes B Fogo; Fiscal Year: 2010
    ..These approaches could ultimately identify novel therapeutic targets in FSGS. ..
  27. Secretomes captured in vivo via ultrafiltration probes
    Chun Ming Huang; Fiscal Year: 2008
    ..We believe that using CUF probes/Mass spectrometry will be a powerful tool which can be applied to other animal models and other human diseases. [unreadable] [unreadable] [unreadable]..
  28. HSP27 in Kidney Epithelial to Mesenchymal Transformation
    Arjang Djamali; Fiscal Year: 2008
    ..Overexpression of HSP27 will be obtained by recombinant virus-mediated HSP27 gene transfer. This proposal would allow us to determine whether HSP27 overexpression can prevent/delay EMT. ..
  29. The Biology and Function of BMP-7 in the Kidney
    Raghu Kalluri; Fiscal Year: 2007
    ..The physiological role of BMP-7 in kidney health and pathology will be established. These studies will directly benefit the development of this molecule in the clinic as a drug for patients with kidney fibrosis. ..
  30. Anthrax vaccination by targeting spore germination
    Chun Ming Huang; Fiscal Year: 2005
    ..This unprecedented study will elicit the pathological mechanisms and vaccination capabilities of immune inhibitor A and camelysin expressed in Bacillus anthracis. ..
  31. Regulation of Angiogenesis by Tumstatin
    Raghu Kalluri; Fiscal Year: 2006
    ..abstract_text> ..
  32. International Meeting--Epithelial /Mesenchymal Tranition
    Raghu Kalluri; Fiscal Year: 2005
    ..abstract_text> ..
  33. ANTI-GLOMERULAR BASEMENT MEMBRANE DISEASE
    Raghu Kalluri; Fiscal Year: 2001
    ..Successful completion of this project should provide new experimental information regarding the processes that govern the pathogenesis of human anti-GBM disease. ..
  34. Acne Vaccines Targeting a Surface Sialidase and a Secreted CAMP Factor Toxin
    Chun Ming Huang; Fiscal Year: 2008
    ..The goal of this proposal is to develop systemically effective acne vaccines that can specifically suppress P. acnes-induced skin inflammation without disturbing the balance of skin flora. [unreadable] [unreadable] [unreadable]..
  35. Role of Fibroblasts in Cancer
    Raghu Kalluri; Fiscal Year: 2010
    ..microenvironment, we have now identified a population of CAF that are positive for fibroblast specific protein-1 (FSP1) but not for alpha-smooth muscle actin (alphaSMA)...
  36. Matrix Microenvironment and Liver Fibrosis
    Raghu Kalluri; Fiscal Year: 2007
    ..Therefore, this application is well poised to identify a unique mechanism of liver fibrosis and also study a therapeutic agent, which works against this mechanism and inhibits progression of liver disease. ..
  37. S100A4: A Novel Regulator of Biomineralization
    WAGNER DUARTE; Fiscal Year: 2003
    ..b>S100A4 is a calcium-binding protein that has been implicated in cancer metastasis, however, recent evidence has shown ..