S100A4

Summary

Gene Symbol: S100A4
Description: S100 calcium binding protein A4
Alias: 18A2, 42A, CAPL, FSP1, MTS1, P9KA, PEL98, protein S100-A4, S100 calcium-binding protein A4 (calcium protein, calvasculin, metastasin, murine placental homolog), calcium placental protein, fibroblast-specific protein-1, leukemia multidrug resistance associated protein, malignant transformation suppression 1, metastasin 1, murine placental homolog, placental calcium-binding protein, protein Mts1
Species: human
Products:     S100A4

Top Publications

  1. Boye K, Maelandsmo G. S100A4 and metastasis: a small actor playing many roles. Am J Pathol. 2010;176:528-35 pubmed publisher
    The calcium-binding protein S100A4 promotes metastasis in several experimental animal models, and S100A4 protein expression is associated with patient outcome in a number of tumor types...
  2. Ma X, Yang Y, Wang Y, An G, Lv G. Small interfering RNA-directed knockdown of S100A4 decreases proliferation and invasiveness of osteosarcoma cells. Cancer Lett. 2010;299:171-81 pubmed publisher
    ..b>S100A4 has been implicated in the proliferation, cell cycle progression, and metastasis of many malignant tumors, ..
  3. Dahlmann M, Sack U, Herrmann P, Lemm M, Fichtner I, Schlag P, et al. Systemic shRNA mediated knock down of S100A4 in colorectal cancer xenografted mice reduces metastasis formation. Oncotarget. 2012;3:783-97 pubmed
    The metastasis-inducing protein S100A4 was found to be a prognostic indicator for the development of metachronous metastases...
  4. Zou M, Famulski K, Parhar R, Baitei E, Al Mohanna F, Farid N, et al. Microarray analysis of metastasis-associated gene expression profiling in a murine model of thyroid carcinoma pulmonary metastasis: identification of S100A4 (Mts1) gene overexpression as a poor prognostic marker for thyroid carcinoma. J Clin Endocrinol Metab. 2004;89:6146-54 pubmed
    ..to tumor progression were identified, such as c-Met, ezrin, integrin, motility-related protein-1, cadherin, and S100A4. The most highly expressed gene is the S100A4 (8-fold higher than control), which is a member of a small calcium ..
  5. Ikenaga N, Ohuchida K, Mizumoto K, Yu J, Fujita H, Nakata K, et al. S100A4 mRNA is a diagnostic and prognostic marker in pancreatic carcinoma. J Gastrointest Surg. 2009;13:1852-8 pubmed publisher
    The aim of this study is to evaluate the clinical significance of S100A4 mRNA expression in pancreatic cancer...
  6. Xie R, Schlumbrecht M, Shipley G, Xie S, Bassett R, Broaddus R. S100A4 mediates endometrial cancer invasion and is a target of TGF-beta1 signaling. Lab Invest. 2009;89:937-47 pubmed publisher
    The molecular mechanisms of endometrial cancer invasion are poorly understood. S100A4, also known as FSP1 (fibroblast-specific protein 1), has long been known to be a molecular marker of fibrosis in a variety of different fibrotic ..
  7. Zibert J, Skov L, Thyssen J, Jacobsen G, Grigorian M. Significance of the S100A4 protein in psoriasis. J Invest Dermatol. 2010;130:150-60 pubmed publisher
    The S100A4 protein is reported as a pivotal player in the tumor microenvironment with a metastasis-promoting function...
  8. Taylor S, Herrington S, Prime W, Rudland P, Barraclough R. S100A4 (p9Ka) protein in colon carcinoma and liver metastases: association with carcinoma cells and T-lymphocytes. Br J Cancer. 2002;86:409-16 pubmed
    The presence of the EF-hand-calcium-binding protein S100A4 in the carcinoma cells of the primary tumour is associated with a shorter survival time of a group of breast cancer patients...
  9. Zhang K, Zhang M, Zhao H, Yan B, Zhang D, Liang J. S100A4 regulates motility and invasiveness of human esophageal squamous cell carcinoma through modulating the AKT/Slug signal pathway. Dis Esophagus. 2012;25:731-9 pubmed publisher
    The involvement of S100A4 in modulating invasiveness of esophageal squamous cell carcinoma (ESCC) cell lines was explored. It was shown that S100A4 expression is positively correlated with the degree of invasiveness in human ESCC cells...

More Information

Publications92

  1. Li N, Song M, Chen X, Liu L, Li F. S100A4 siRNA inhibits human pancreatic cancer cell invasion in vitro. Biomed Environ Sci. 2012;25:465-70 pubmed publisher
    Pancreatic cancer is one of the most deadly cancers, which is characterized by its high metastatic potential. S100A4 is a major prometastatic protein involved in tumor invasion and metastasis which precise role in pancreatic cancer has ..
  2. Boye K, Nesland J, Sandstad B, Mælandsmo G, Flatmark K. Nuclear S100A4 is a novel prognostic marker in colorectal cancer. Eur J Cancer. 2010;46:2919-25 pubmed publisher
    ..b>S100A4 is a Ca(2+)-binding protein which promotes metastasis in several tumour types, and the aim of the present study ..
  3. Takenaga K, Nygren J, Zelenina M, Ohira M, Iuchi T, Lukanidin E, et al. Modified expression of Mts1/S100A4 protein in C6 glioma cells or surrounding astrocytes affects migration of tumor cells in vitro and in vivo. Neurobiol Dis. 2007;25:455-63 pubmed
    The calcium-binding Mts1/S100A4 protein plays an important role in motility and metastatic activity of tumor cells...
  4. Radestock Y, Hoang Vu C, Hombach Klonisch S. Relaxin downregulates the calcium binding protein S100A4 in MDA-MB-231 human breast cancer cells. Ann N Y Acad Sci. 2005;1041:462-9 pubmed
    ..Our investigations revealed downregulation of mRNA and protein of the calcium binding protein S100A4 (metastasin) in MDA-MB-231/pIRES-EGFP-H2 transfectants, indicating a distinct and novel role for relaxin in ..
  5. Chen H, Fernig D, Rudland P, Sparks A, Wilkinson M, Barraclough R. Binding to intracellular targets of the metastasis-inducing protein, S100A4 (p9Ka). Biochem Biophys Res Commun. 2001;286:1212-7 pubmed
    Experimentally elevated levels of S100A4 induce a metastatic phenotype in benign mammary tumour cells in vivo. In humans, the presence of S100A4 in breast cancer cells correlates strongly with reduced patient survival...
  6. Chen D, Zheng X, Yang Z, Liu D, Zhang G, Jiao X, et al. S100A4 silencing blocks invasive ability of esophageal squamous cell carcinoma cells. World J Gastroenterol. 2012;18:915-22 pubmed publisher
    To investigate a potential role of S100A4 in esophagus squamous cell carcinoma metastasis (ESCCs)...
  7. Rosty C, Ueki T, Argani P, Jansen M, Yeo C, Cameron J, et al. Overexpression of S100A4 in pancreatic ductal adenocarcinomas is associated with poor differentiation and DNA hypomethylation. Am J Pathol. 2002;160:45-50 pubmed
    Using the National Center for Biotechnology Information Serial Analysis of Gene Expression database, we found that S100A4, a calcium-binding protein previously implicated in metastasis, was expressed in five of seven pancreatic carcinoma ..
  8. Kwak J, Lee H, Kim S, Kim H, Mok Y, Park Y, et al. Expression of protein S100A4 is a predictor of recurrence in colorectal cancer. World J Gastroenterol. 2010;16:3897-904 pubmed
    To investigate the prognostic significance of S100A4 expression in colorectal cancer and its correlation with expression of E-cadherin and p53...
  9. Kiss B, Duelli A, Radnai L, Kekesi K, Katona G, Nyitray L. Crystal structure of the S100A4-nonmuscle myosin IIA tail fragment complex reveals an asymmetric target binding mechanism. Proc Natl Acad Sci U S A. 2012;109:6048-53 pubmed publisher
    b>S100A4 is a member of the S100 family of calcium-binding proteins that is directly involved in tumor metastasis...
  10. Tabata T, Tsukamoto N, Fooladi A, Yamanaka S, Furukawa T, Ishida M, et al. RNA interference targeting against S100A4 suppresses cell growth and motility and induces apoptosis in human pancreatic cancer cells. Biochem Biophys Res Commun. 2009;390:475-80 pubmed publisher
    b>S100A4 protein belongs to the S100 subfamily, which has grown to be one of the large subfamilies of the EF-hand Ca(2+)-binding proteins, and overexpression of S100A4 is suggested to associate with cell proliferation, invasion, and ..
  11. Jia W, Gao X, Zhang Z, Yang Z, Zhang G. S100A4 silencing suppresses proliferation, angiogenesis and invasion of thyroid cancer cells through downregulation of MMP-9 and VEGF. Eur Rev Med Pharmacol Sci. 2013;17:1495-508 pubmed
    It is well documented that S100A4 is upregulated in many cancers and plays a pivotal role in tumor proliferation, invasion, metastasis and angiogenesis...
  12. Zou M, Al Baradie R, Al Hindi H, Farid N, Shi Y. S100A4 (Mts1) gene overexpression is associated with invasion and metastasis of papillary thyroid carcinoma. Br J Cancer. 2005;93:1277-84 pubmed
    Tumour cell invasion and metastasis are the hallmark of malignant neoplasm. S100A4 is a member of small calcium-binding protein family and is involved in the cell proliferation and cancer progression...
  13. Andersen K, Mori H, Fata J, Bascom J, Oyjord T, Mælandsmo G, et al. The metastasis-promoting protein S100A4 regulates mammary branching morphogenesis. Dev Biol. 2011;352:181-90 pubmed publisher
    High levels of the S100 calcium binding protein S100A4 also called fibroblast specific protein 1 (FSP1) have been established as an inducer of metastasis and indicator of poor prognosis in breast cancer...
  14. Huang L, Xu Y, Cai G, Guan Z, Cai S. Downregulation of S100A4 expression by RNA interference suppresses cell growth and invasion in human colorectal cancer cells. Oncol Rep. 2012;27:917-22 pubmed publisher
    b>S100A4 protein, a member of the S100 superfamily of calcium-binding proteins, is frequently observed in various types of human cancers, including colorectal cancer (CRC)...
  15. Badyal S, Basran J, Bhanji N, Kim J, Chavda A, Jung H, et al. Mechanism of the Ca²+-dependent interaction between S100A4 and tail fragments of nonmuscle myosin heavy chain IIA. J Mol Biol. 2011;405:1004-26 pubmed publisher
    The interaction between the calcium-binding protein S100A4 and the C-terminal fragments of nonmuscle myosin heavy chain IIA has been studied by equilibrium and kinetic methods...
  16. Zhang H, Zheng X, Wang X, Xuan X, Wang F, Li S. S100A4 mediated cell invasion and metastasis of esophageal squamous cell carcinoma via the regulation of MMP-2 and E-cadherin activity. Mol Biol Rep. 2012;39:199-208 pubmed publisher
    It is well documented that S100A4 is upregulated in a large amount of invasive tumors and plays a pivotal role in tumor invasion and metastasis...
  17. Bettum I, Vasiliauskaite K, Nygaard V, Clancy T, Pettersen S, Tenstad E, et al. Metastasis-associated protein S100A4 induces a network of inflammatory cytokines that activate stromal cells to acquire pro-tumorigenic properties. Cancer Lett. 2014;344:28-39 pubmed publisher
    ..we show that the stroma adjacent to metastatic lesions is enriched in the known metastasis-promoting protein S100A4. S100A4 stimulates cancer cells to secrete paracrine factors, such as inflammatory cytokines IL8, CCL2 and SAA, ..
  18. Ramagopal U, Dulyaninova N, Varney K, Wilder P, Nallamsetty S, Brenowitz M, et al. Structure of the S100A4/myosin-IIA complex. BMC Struct Biol. 2013;13:31 pubmed publisher
    b>S100A4, a member of the S100 family of Ca2+-binding proteins, modulates the motility of both non-transformed and cancer cells by regulating the localization and stability of cellular protrusions...
  19. Dahlmann M, Okhrimenko A, Marcinkowski P, Osterland M, Herrmann P, Smith J, et al. RAGE mediates S100A4-induced cell motility via MAPK/ERK and hypoxia signaling and is a prognostic biomarker for human colorectal cancer metastasis. Oncotarget. 2014;5:3220-33 pubmed
    Survival of colorectal cancer patients is strongly dependent on development of distant metastases. S100A4 is a prognostic biomarker and inducer for colorectal cancer metastasis...
  20. Sherbet G. Metastasis promoter S100A4 is a potentially valuable molecular target for cancer therapy. Cancer Lett. 2009;280:15-30 pubmed publisher
    ..Several genetic determinants relating to proliferation and growth, invasion and metastasis have been identified. S100A4 appears to be able to activate and integrate pathways to generate the phenotypic responses that are characteristic ..
  21. Tsuna M, Kageyama S, Fukuoka J, Kitano H, Doki Y, Tezuka H, et al. Significance of S100A4 as a prognostic marker of lung squamous cell carcinoma. Anticancer Res. 2009;29:2547-54 pubmed
    ..Here, the aim was to assess whether S100A4 could also be a prognostic biomarker of lung cancer...
  22. Elliott P, Irvine A, Jung H, Tozawa K, Pastok M, Picone R, et al. Asymmetric mode of Ca²?-S100A4 interaction with nonmuscle myosin IIA generates nanomolar affinity required for filament remodeling. Structure. 2012;20:654-66 pubmed publisher
    Filament assembly of nonmuscle myosin IIA (NMIIA) is selectively regulated by the small Ca²?-binding protein, S100A4, which causes enhanced cell migration and metastasis in certain cancers...
  23. Sekine H, Chen N, Sato K, Saiki Y, Yoshino Y, Umetsu Y, et al. S100A4, frequently overexpressed in various human cancers, accelerates cell motility in pancreatic cancer cells. Biochem Biophys Res Commun. 2012;429:214-9 pubmed publisher
    b>S100A4, a member of the Ca(2+) dependent S100 protein family, is reported to associate with metastasis through regulation of the motility and invasiveness of cancer cells...
  24. Endo H, Takenaga K, Kanno T, Satoh H, Mori S. Methionine aminopeptidase 2 is a new target for the metastasis-associated protein, S100A4. J Biol Chem. 2002;277:26396-402 pubmed
    b>S100A4 is an EF-hand type calcium-binding protein that regulates tumor metastasis and a variety of cellular processes via interaction with different target proteins...
  25. Ito Y, Yoshida H, Tomoda C, Uruno T, Miya A, Kobayashi K, et al. S100A4 expression is an early event of papillary carcinoma of the thyroid. Oncology. 2004;67:397-402 pubmed
    b>S100A4 is a calcium-binding protein related to the metastatic potential of carcinoma. In order to elucidate its contribution to the progression of thyroid carcinoma, we investigated S100A4 expression in various thyroid neoplasms...
  26. Chen M, Sinha M, Luxon B, Bresnick A, O Connor K. Integrin alpha6beta4 controls the expression of genes associated with cell motility, invasion, and metastasis, including S100A4/metastasin. J Biol Chem. 2009;284:1484-94 pubmed publisher
    ..01). Of these genes, 36 are associated with pathways implicated in cell motility and metastasis, including S100A4/metastasin. S100A4 expression correlated well with integrin alpha6beta4 expression in established cell lines...
  27. Belot N, Pochet R, Heizmann C, Kiss R, Decaestecker C. Extracellular S100A4 stimulates the migration rate of astrocytic tumor cells by modifying the organization of their actin cytoskeleton. Biochim Biophys Acta. 2002;1600:74-83 pubmed
    In previous studies, we have shown that numbers of S100 calcium-binding proteins (including S100A4) are expressed differentially in astrocytic tumors according to their levels of malignancy...
  28. Vallely K, Rustandi R, Ellis K, Varlamova O, Bresnick A, Weber D. Solution structure of human Mts1 (S100A4) as determined by NMR spectroscopy. Biochemistry. 2002;41:12670-80 pubmed
    b>Mts1 is a member of the S100 family of Ca2+-binding proteins and is implicated in promoting tumor progression and metastasis...
  29. Mencia N, Selga E, Rico I, de Almagro M, Villalobos X, Ramirez S, et al. Overexpression of S100A4 in human cancer cell lines resistant to methotrexate. BMC Cancer. 2010;10:250 pubmed publisher
    ..b>S100A4 mRNA and protein levels were determined by RT-Real-Time PCR and Western blot, respectively...
  30. Garrett S, Hodgson L, Rybin A, Toutchkine A, Hahn K, Lawrence D, et al. A biosensor of S100A4 metastasis factor activation: inhibitor screening and cellular activation dynamics. Biochemistry. 2008;47:986-96 pubmed
    b>S100A4, a member of the S100 family of Ca2+-binding proteins, displays elevated expression in malignant human tumors compared with benign tumors, and increased expression correlates strongly with poor patient survival...
  31. Wang L, Wang X, Liang Y, Diao X, Chen Q. S100A4 promotes invasion and angiogenesis in breast cancer MDA-MB-231 cells by upregulating matrix metalloproteinase-13. Acta Biochim Pol. 2012;59:593-8 pubmed
    b>S100A4 is a member of the S100 family of calcium-binding proteins that is directly involved in tumor metastasis...
  32. Huang L, Xu Y, Cai G, Guan Z, Sheng W, Lu H, et al. S100A4 over-expression underlies lymph node metastasis and poor prognosis in colorectal cancer. World J Gastroenterol. 2011;17:69-78 pubmed publisher
    ..Forty-three proteins were found to be differentially expressed by at least 2.5-fold in two types of CRC. S100A4 was significantly upregulated in LNM CRC compared with non-LNM CRC, which was confirmed by Western blotting, ..
  33. Li Z, Spektor A, Varlamova O, Bresnick A. Mts1 regulates the assembly of nonmuscle myosin-IIA. Biochemistry. 2003;42:14258-66 pubmed
    ..In contrast, we demonstrate that mts1, a member of the Ca(2+)-regulated S100 family of proteins, may regulate the monomeric, unassembled state in an ..
  34. Mathisen B, Lindstad R, Hansen J, El Gewely S, Maelandsmo G, Hovig E, et al. S100A4 regulates membrane induced activation of matrix metalloproteinase-2 in osteosarcoma cells. Clin Exp Metastasis. 2003;20:701-11 pubmed
    To study the role of the metastasis associated protein S100A4, an osteosarcoma cell line (OHS) with a high level of this protein was transfected with a vector containing a ribozyme that degrades S100A4 mRNA and, as controls, OHS cells ..
  35. Zhang J, Zhang D, Jiao X, Dong Q. S100A4 regulates migration and invasion in hepatocellular carcinoma HepG2 cells via NF-?B-dependent MMP-9 signal. Eur Rev Med Pharmacol Sci. 2013;17:2372-82 pubmed
    We previously showed that the calcium-binding protein S100A4 is overexpressed and related to metastasis in hepatocellular carcinoma (HCC)...
  36. Ismail T, Fernig D, Rudland P, Terry C, Wang G, Barraclough R. The basic C-terminal amino acids of calcium-binding protein S100A4 promote metastasis. Carcinogenesis. 2008;29:2259-66 pubmed publisher
    The calcium-binding protein S100A4 can induce a metastatic phenotype in animal model systems and its expression in various human cancers has been shown to be associated with metastasis and reduced patient survival...
  37. Kang Y, Jung C, Lee A, Kang W, Oh S, Kang C. Prognostic significance of S100A4 mRNA and protein expression in colorectal cancer. J Surg Oncol. 2012;105:119-24 pubmed publisher
    The calcium-binding protein S100A4 promotes tumor progression and metastasis. We investigated the expression of S100A4 in colorectal cancer and its clinicopathologic significance in colorectal cancer...
  38. Fabris L, Cadamuro M, Moserle L, Dziura J, Cong X, Sambado L, et al. Nuclear expression of S100A4 calcium-binding protein increases cholangiocarcinoma invasiveness and metastasization. Hepatology. 2011;54:890-9 pubmed publisher
    ..The mechanisms responsible for CCA invasiveness are unclear. S100A4, a member of the S100 family of small Ca(2+)-binding proteins, is expressed in mesenchymal cells, regulates cell ..
  39. Gingras A, Basran J, Prescott A, Kriajevska M, Bagshaw C, Barsukov I. Crystal structure of the Ca(2+)-form and Ca(2+)-binding kinetics of metastasis-associated protein, S100A4. FEBS Lett. 2008;582:1651-6 pubmed publisher
    b>S100A4 takes part in control of tumour cell migration and contributes to metastatic spread in in vivo models. In the active dimeric Ca(2+)-bound state it interacts with multiple intracellular targets...
  40. Xie R, Loose D, Shipley G, Xie S, Bassett R, Broaddus R. Hypomethylation-induced expression of S100A4 in endometrial carcinoma. Mod Pathol. 2007;20:1045-54 pubmed
    ..We hypothesized that S100A4 would be overexpressed in endometrial carcinoma compared to benign endometrium...
  41. Grigorian M, Andresen S, Tulchinsky E, Kriajevska M, Carlberg C, Kruse C, et al. Tumor suppressor p53 protein is a new target for the metastasis-associated Mts1/S100A4 protein: functional consequences of their interaction. J Biol Chem. 2001;276:22699-708 pubmed
    A physical and functional interaction between the Ca(2+)-binding protein Mts1 (S100A4) and the tumor suppressor p53 protein is shown here for the first time...
  42. Pedersen M, Køhler L, Grigorian M, Novitskaya V, Bock E, Lukanidin E, et al. The Mts1/S100A4 protein is a neuroprotectant. J Neurosci Res. 2004;77:777-86 pubmed
    Mts1 (S100A4) is a calcium-binding protein of the EF-hand type, belonging to the S100 family of proteins...
  43. Matsuura I, Lai C, Chiang K. Functional interaction between Smad3 and S100A4 (metastatin-1) for TGF-beta-mediated cancer cell invasiveness. Biochem J. 2010;426:327-35 pubmed publisher
    ..In the present study, we show that S100A4, a metastasis-associated protein, also called metastatin-1, can physically and functionally interact with Smad3, ..
  44. De Silva Rudland S, Martin L, Roshanlall C, Winstanley J, Leinster S, Platt Higgins A, et al. Association of S100A4 and osteopontin with specific prognostic factors and survival of patients with minimally invasive breast cancer. Clin Cancer Res. 2006;12:1192-200 pubmed
    b>S100A4 and the estrogen-inducible osteopontin are alone capable of inducing angiogenesis and metastasis in rodent models for breast cancer...
  45. Kim E, Helfman D. Characterization of the metastasis-associated protein, S100A4. Roles of calcium binding and dimerization in cellular localization and interaction with myosin. J Biol Chem. 2003;278:30063-73 pubmed
    Elevated S100A4 protein expression is associated with metastatic tumor progression and appears to be a strong molecular marker for clinical prognosis...
  46. Fujiwara M, Kashima T, Kunita A, Kii I, Komura D, Grigoriadis A, et al. Stable knockdown of S100A4 suppresses cell migration and metastasis of osteosarcoma. Tumour Biol. 2011;32:611-22 pubmed publisher
    b>S100A4, a 10-12 kDa calcium-binding protein, plays functional roles in tumor progression and metastasis. The present study aimed to investigate the function of S100A4 in osteosarcoma (OS) metastasis, using a loss-of-function approach...
  47. Yang H, Zhao K, Yu Q, Wang X, Song Y, Li R. Evaluation of plasma and tissue S100A4 protein and mRNA levels as potential markers of metastasis and prognosis in clear cell renal cell carcinoma. J Int Med Res. 2012;40:475-85 pubmed
    To investigate levels of S100A4 protein in plasma and S100A4 mRNA in tumours from patients with clear cell renal cell carcinoma (CCRCC), and correlate these with metastasis, survival and levels of vascular endothelial growth factor (VEGF)...
  48. Tarabykina S, Scott D, Herzyk P, Hill T, Tame J, Kriajevska M, et al. The dimerization interface of the metastasis-associated protein S100A4 (Mts1): in vivo and in vitro studies. J Biol Chem. 2001;276:24212-22 pubmed
    ..In this study we characterized the dimerization of S100A4 (also named Mts1) in vitro and in vivo...
  49. Takenaga K, Nakamura Y, Sakiyama S, Hasegawa Y, Sato K, Endo H. Binding of pEL98 protein, an S100-related calcium-binding protein, to nonmuscle tropomyosin. J Cell Biol. 1994;124:757-68 pubmed
    ..experiment revealed that the 10-kD protein was identical to a calcium-binding protein derived from mRNA named pEL98 or 18A2 that is homologous to S100 protein...
  50. Hua J, Chen D, Fu H, Zhang R, Shen W, Liu S, et al. Short hairpin RNA-mediated inhibition of S100A4 promotes apoptosis and suppresses proliferation of BGC823 gastric cancer cells in vitro and in vivo. Cancer Lett. 2010;292:41-7 pubmed publisher
    b>S100A4 has been found to be over-expressed in gastric cancer and associated with poor prognosis of the patients, yet the exact role and molecular mechanism of S100A4 in gastric cancer has not been determined...
  51. Cabezon T, Celis J, Skibshøj I, Klingelhofer J, Grigorian M, Gromov P, et al. Expression of S100A4 by a variety of cell types present in the tumor microenvironment of human breast cancer. Int J Cancer. 2007;121:1433-44 pubmed
    The S100A4 protein, which is involved in the metastasis process, is a member of the S100 superfamily of Ca-binding proteins...
  52. Malashkevich V, Varney K, Garrett S, Wilder P, Knight D, Charpentier T, et al. Structure of Ca2+-bound S100A4 and its interaction with peptides derived from nonmuscle myosin-IIA. Biochemistry. 2008;47:5111-26 pubmed publisher
    b>S100A4, also known as mts1, is a member of the S100 family of Ca2+-binding proteins that is directly involved in tumor invasion and metastasis via interactions with specific protein targets, including nonmuscle myosin-IIA (MIIA)...
  53. Pathuri P, Vogeley L, Luecke H. Crystal structure of metastasis-associated protein S100A4 in the active calcium-bound form. J Mol Biol. 2008;383:62-77 pubmed publisher
    b>S100A4 (metastasin) is a member of the S100 family of calcium-binding proteins that is directly involved in tumorigenesis...
  54. Klingelhofer J, Møller H, Sumer E, Berg C, Poulsen M, Kiryushko D, et al. Epidermal growth factor receptor ligands as new extracellular targets for the metastasis-promoting S100A4 protein. FEBS J. 2009;276:5936-48 pubmed publisher
    The function of S100A4, a member of the calcium-binding S100 protein family, has been associated with tumor invasion and metastasis...
  55. Wang Y, Ye Z, Zhao Z, Tao H, Chu Y. High-level expression of S100A4 correlates with lymph node metastasis and poor prognosis in patients with gastric cancer. Ann Surg Oncol. 2010;17:89-97 pubmed publisher
    ..0 array. The expression of S100A4 was detected by real-time quantitative reverse-transcription polymerase chain reaction (RT-PCR) in gastric tumor ..
  56. Wang G, Zhang S, Fernig D, Martin Fernandez M, Rudland P, Barraclough R. Mutually antagonistic actions of S100A4 and S100A1 on normal and metastatic phenotypes. Oncogene. 2005;24:1445-54 pubmed
    Increased levels of the homodimeric calcium-binding protein, S100A4, have been shown to cause a metastatic phenotype in at least three independent model systems of breast cancer and its presence in carcinoma cells has been shown to be ..
  57. Kriajevska M, Fischer Larsen M, Moertz E, Vorm O, Tulchinsky E, Grigorian M, et al. Liprin beta 1, a member of the family of LAR transmembrane tyrosine phosphatase-interacting proteins, is a new target for the metastasis-associated protein S100A4 (Mts1). J Biol Chem. 2002;277:5229-35 pubmed
    Metastasis-associated protein S100A4 (Mts1) induces invasiveness of primary tumors and promotes metastasis...
  58. Malashkevich V, Dulyaninova N, Ramagopal U, Liriano M, Varney K, Knight D, et al. Phenothiazines inhibit S100A4 function by inducing protein oligomerization. Proc Natl Acad Sci U S A. 2010;107:8605-10 pubmed publisher
    b>S100A4, a member of the S100 family of Ca(2+)-binding proteins, regulates carcinoma cell motility via interactions with myosin-IIA...
  59. Pedersen K, Nesland J, Fodstad Ø, Maelandsmo G. Expression of S100A4, E-cadherin, alpha- and beta-catenin in breast cancer biopsies. Br J Cancer. 2002;87:1281-6 pubmed
    In 66 breast cancer biopsies, the expression of the Ca(2+)-binding protein S100A4, E-cadherin, alpha- and beta-catenin was examined by immunohistochemistry, and the results were related to clinical and pathological parameters...
  60. Klingelhofer J, Senolt L, Baslund B, Nielsen G, Skibshøj I, Pavelka K, et al. Up-regulation of metastasis-promoting S100A4 (Mts-1) in rheumatoid arthritis: putative involvement in the pathogenesis of rheumatoid arthritis. Arthritis Rheum. 2007;56:779-89 pubmed
    To examine the involvement of the metastasis-inducing protein S100A4 (Mts-1) in the pathogenesis of rheumatoid arthritis (RA)...
  61. Ochiya T, Takenaga K, Endo H. Silencing of S100A4, a metastasis-associated protein, in endothelial cells inhibits tumor angiogenesis and growth. Angiogenesis. 2014;17:17-26 pubmed publisher
    Endothelial cells express S100A4, a metastasis-associated protein, but its role in angiogenesis remains to be elucidated...
  62. Schafer B, Wicki R, Engelkamp D, Mattei M, Heizmann C. Isolation of a YAC clone covering a cluster of nine S100 genes on human chromosome 1q21: rationale for a new nomenclature of the S100 calcium-binding protein family. Genomics. 1995;25:638-43 pubmed
    ..The new nomenclature should facilitate and further the understanding of this protein family and be easily expandable to other species. ..
  63. Maelandsmo G, Flørenes V, Nguyen M, Flatmark K, Davidson B. Different expression and clinical role of S100A4 in serous ovarian carcinoma at different anatomic sites. Tumour Biol. 2009;30:15-25 pubmed publisher
    The present study analyzed the site-specific expression and clinical role of S100A4 in advanced-stage ovarian carcinoma (OC)...
  64. Garrett S, Varney K, Weber D, Bresnick A. S100A4, a mediator of metastasis. J Biol Chem. 2006;281:677-80 pubmed
  65. Ford H, Silver D, Kachar B, Sellers J, Zain S. Effect of Mts1 on the structure and activity of nonmuscle myosin II. Biochemistry. 1997;36:16321-7 pubmed
    The mts1 gene codes for a 9 kDa protein belonging to the S100 subfamily of Ca2+-binding proteins and is known to play a role in metastasis...
  66. Lo J, Yu C, Chiou S, Huang C, Jan C, Lin S, et al. The epithelial-mesenchymal transition mediator S100A4 maintains cancer-initiating cells in head and neck cancers. Cancer Res. 2011;71:1912-23 pubmed publisher
    ..HN-CIC), we determined as a candidate stemness-maintaining molecule for HN-CICs the proinflammatory mediator S100A4, which is also known to be an inducer of epithelial-mesenchymal transition...
  67. Yammani R, Carlson C, Bresnick A, Loeser R. Increase in production of matrix metalloproteinase 13 by human articular chondrocytes due to stimulation with S100A4: Role of the receptor for advanced glycation end products. Arthritis Rheum. 2006;54:2901-11 pubmed
    ..The aims of this study were to determine whether chondrocytes produce S100A4 and whether S100A4 can stimulate the production of matrix metalloproteinase 13 (MMP-13) by articular chondrocytes ..
  68. Rivard C, Brown L, Almeida N, Maunsbach A, Pihakaski Maunsbach K, Andres Hernando A, et al. Expression of the calcium-binding protein S100A4 is markedly up-regulated by osmotic stress and is involved in the renal osmoadaptive response. J Biol Chem. 2007;282:6644-52 pubmed
    ..Of these proteins, one of the most robustly up-regulated (22-fold) was S100A4. The identity of the protein was verified by high pressure liquid chromatography-mass spectrometry...
  69. EL Naaman C, Grum Schwensen B, Mansouri A, Grigorian M, Santoni Rugiu E, Hansen T, et al. Cancer predisposition in mice deficient for the metastasis-associated Mts1(S100A4) gene. Oncogene. 2004;23:3670-80 pubmed
    Metastasis-promoting Mts1(S100A4) protein belongs to the S100 family of Ca(2+)-binding proteins. A mouse strain with a germ-line inactivation of the S100A4 gene was generated...
  70. Yu C, Tsai C, Hsu H, Chang Y. Elevation of S100A4 expression in buccal mucosal fibroblasts by arecoline: involvement in the pathogenesis of oral submucous fibrosis. PLoS ONE. 2013;8:e55122 pubmed publisher
    b>S100A4, a member of the calcium-binding proteins, is dramatically elevated in a variety of fibrotic diseases. Areca quid chewing is the most important etiological factor in the pathogenesis of oral submucous fibrosis (OSF)...
  71. Tarabykina S, Griffiths T, Tulchinsky E, Mellon J, Bronstein I, Kriajevska M. Metastasis-associated protein S100A4: spotlight on its role in cell migration. Curr Cancer Drug Targets. 2007;7:217-28 pubmed
    b>S100A4 (also known as Mts1, metastasin, p9Ka, pEL98, CAPL, calvasculin, Fsp-1, placental calcium-binding protein) belongs to the family of EF-hand calcium-binding proteins, whose expression is elevated in a number of pathological ..
  72. Saleem M, Kweon M, Johnson J, Adhami V, Elcheva I, Khan N, et al. S100A4 accelerates tumorigenesis and invasion of human prostate cancer through the transcriptional regulation of matrix metalloproteinase 9. Proc Natl Acad Sci U S A. 2006;103:14825-30 pubmed
    We previously showed that the calcium-binding protein S100A4 is overexpressed during the progression of prostate cancer (CaP) in humans and in the TRAMP (transgenic adenocarcinoma of the mouse prostate) mouse model...
  73. Ai K, Lu L, Huang X, Chen W, Zhang H. Prognostic significance of S100A4 and vascular endothelial growth factor expression in pancreatic cancer. World J Gastroenterol. 2008;14:1931-5 pubmed
    To investigate the expression of vascular endothelial growth factor (VEGF) and calcium-binding protein S100A4 in pancreatic cancer and their relationship to the clinicopathological parameters and prognosis of pancreatic cancer...
  74. Li C, Martinez V, He B, Lombet A, Perbal B. A role for CCN3 (NOV) in calcium signalling. Mol Pathol. 2002;55:250-61 pubmed
    ..The two hybrid system identified the S100A4 (mts1) calcium binding protein as a partner of CCN3 and the use of the GST fusion proteins showed that the ..
  75. Ismail T, Zhang S, Fernig D, Gross S, Martin Fernandez M, See V, et al. Self-association of calcium-binding protein S100A4 and metastasis. J Biol Chem. 2010;285:914-22 pubmed publisher
    Elevated levels of the calcium-binding protein S100A4 promote metastasis and in carcinoma cells are associated with reduced survival of cancer patients...
  76. Feng L, Zheng X, Zhou L, Fu B, Yu Y, Lu S, et al. Correlation between expression of S100A4 and VEGF-C, and lymph node metastasis and prognosis in gastric carcinoma. J Int Med Res. 2011;39:1333-43 pubmed
    This semiquantitative immunohistochemical study investigated the clinical significance of S100A4 and vascular endothelial growth factor C (VEGF-C) protein expression in gastric carcinoma...
  77. Semov A, Moreno M, Onichtchenko A, Abulrob A, Ball M, Ekiel I, et al. Metastasis-associated protein S100A4 induces angiogenesis through interaction with Annexin II and accelerated plasmin formation. J Biol Chem. 2005;280:20833-41 pubmed
    Many advanced tumors overexpress and secrete the S100A4 protein that is known to promote angiogenesis and metastasis development. The mechanisms of this effect and the endothelial receptor for S100A4 are both still unknown...
  78. Mahon P, Baril P, Bhakta V, Chelala C, Caulee K, Harada T, et al. S100A4 contributes to the suppression of BNIP3 expression, chemoresistance, and inhibition of apoptosis in pancreatic cancer. Cancer Res. 2007;67:6786-95 pubmed
    ..This analysis identified several S100 family proteins, of which two, S100A2 and S100A4, showed in vitro the ability to repress exogenous BNIP3 promoter activity...
  79. Wang H, Zhang J, Cui J, Tan X, Li W, Gu J, et al. Expression status of S100A14 and S100A4 correlates with metastatic potential and clinical outcome in colorectal cancer after surgery. Oncol Rep. 2010;23:45-52 pubmed
    To investigate whether S100A14 and S100A4 expression correlates with metastatic potential and prognosis in colorectal cancer (CRC), we firstly used RT-PCR analysis to detect mRNA expression of S100A14 and S100A4 in 40 pairs of fresh tumor ..
  80. Boye K, Grotterød I, Aasheim H, Hovig E, Maelandsmo G. Activation of NF-kappaB by extracellular S100A4: analysis of signal transduction mechanisms and identification of target genes. Int J Cancer. 2008;123:1301-10 pubmed publisher
    The metastasis-promoting protein S100A4 stimulates metastatic progression through both intracellular and extracellular functions...
  81. House R, Pozzuto M, Patel P, Dulyaninova N, Li Z, Zencheck W, et al. Two functional S100A4 monomers are necessary for regulating nonmuscle myosin-IIA and HCT116 cell invasion. Biochemistry. 2011;50:6920-32 pubmed publisher
    b>S100A4, a member of the Ca(2+)-activated S100 protein family, regulates the motility and invasiveness of cancer cells. Moreover, high S100A4 expression levels correlate with poor patient survival in several cancers...
  82. Kohya N, Kitajima Y, Jiao W, Miyazaki K. Effects of E-cadherin transfection on gene expression of a gallbladder carcinoma cell line: repression of MTS1/S100A4 gene expression. Int J Cancer. 2003;104:44-53 pubmed
    ..Conventional RT-PCR revealed that E-cadherin transfection suppressed expression of mts1 mRNA and increased that of c-myc and MT1-MMP...
  83. Zhang S, Wang G, Fernig D, Rudland P, Webb S, Barraclough R, et al. Interaction of metastasis-inducing S100A4 protein in vivo by fluorescence lifetime imaging microscopy. Eur Biophys J. 2005;34:19-27 pubmed
    Elevated levels of the calcium-binding regulatory protein, S100A4, have been shown to be causative of a metastatic phenotype in models of cancer metastasis and to be associated with reduced patient survival in breast cancer patients...