RBP4

Summary

Gene Symbol: RBP4
Description: retinol binding protein 4
Alias: MCOPCB10, RDCCAS, retinol-binding protein 4, PRBP, RBP, plasma retinol-binding protein, retinol binding protein 4, plasma, retinol-binding protein 4, interstitial
Species: human
Products:     RBP4

Top Publications

  1. Toruner F, Altinova A, Akturk M, Kaya M, Arslan E, Bukan N, et al. The relationship between adipocyte fatty acid binding protein-4, retinol binding protein-4 levels and early diabetic nephropathy in patients with type 2 diabetes. Diabetes Res Clin Pract. 2011;91:203-7 pubmed publisher
    Adipocyte fatty acid binding protein-4 (A-FABP4) and retinol binding protein-4 (RBP4) have recently been linked to type 2 diabetes mellitus (DM)...
  2. Salgado Somoza A, Teijeira Fernandez E, Rubio J, Couso E, Gonzalez Juanatey J, Eiras S. Coronary artery disease is associated with higher epicardial retinol-binding protein 4 (RBP4) and lower glucose transporter (GLUT) 4 levels in epicardial and subcutaneous adipose tissue. Clin Endocrinol (Oxf). 2012;76:51-8 pubmed publisher
    Retinol-binding protein 4 (RBP4), produced by adipocytes and hepatocytes, contributes to an unfavourable lipid profile and insulin resistance, which can contribute to the development of coronary artery disease (CAD)...
  3. Naylor H, Newcomer M. The structure of human retinol-binding protein (RBP) with its carrier protein transthyretin reveals an interaction with the carboxy terminus of RBP. Biochemistry. 1999;38:2647-53 pubmed
    ..or retinol, vitamin A is transported to the target cells as all-trans-retinol bound to retinol-binding protein (RBP)...
  4. Yang Q, Graham T, Mody N, Preitner F, Peroni O, Zabolotny J, et al. Serum retinol binding protein 4 contributes to insulin resistance in obesity and type 2 diabetes. Nature. 2005;436:356-62 pubmed
    ..Here we show, using DNA arrays, that expression of retinol binding protein-4 (RBP4) is elevated in adipose tissue of adipose-Glut4(-/-) mice...
  5. El Mesallamy H, Hamdy N, Zaghloul A, Sallam A. Serum retinol binding protein-4 and neutrophil gelatinase-associated lipocalin are interrelated in pancreatic cancer patients. Scand J Clin Lab Invest. 2012;72:602-7 pubmed publisher
    ..We aimed to determine serum retinol binding protein-4 (RBP-4) and neutophil gelatinase-associated lipocalin (NGAL) levels in pancreatic cancer patients...
  6. Ost A, Danielsson A, Lidén M, Eriksson U, Nystrom F, Stralfors P. Retinol-binding protein-4 attenuates insulin-induced phosphorylation of IRS1 and ERK1/2 in primary human adipocytes. FASEB J. 2007;21:3696-704 pubmed
    ..Animal models and patients with type 2 diabetes exhibit elevated levels of circulating retinol-binding protein (RBP4), and RBP4 can induce insulin resistance in mice. However, little is known about how RBP4 affects insulin signaling...
  7. Biesalski H, Frank J, Beck S, Heinrich F, Illek B, Reifen R, et al. Biochemical but not clinical vitamin A deficiency results from mutations in the gene for retinol binding protein. Am J Clin Nutr. 1999;69:931-6 pubmed
    ..In both siblings, plasma retinol binding protein (RBP) concentrations were below the limit of detection (<0...
  8. Frey S, Spranger J, Henze A, Pfeiffer A, Schweigert F, Raila J. Factors that influence retinol-binding protein 4-transthyretin interaction are not altered in overweight subjects and overweight subjects with type 2 diabetes mellitus. Metabolism. 2009;58:1386-92 pubmed publisher
    Retinol-binding protein 4 (RBP4) is an adipokine bound in plasma to transthyretin (TTR), which prevents its glomerular filtration and subsequent catabolism in the kidney...
  9. Seeliger M, Biesalski H, Wissinger B, Gollnick H, Gielen S, Frank J, et al. Phenotype in retinol deficiency due to a hereditary defect in retinol binding protein synthesis. Invest Ophthalmol Vis Sci. 1999;40:3-11 pubmed
    ..compound heterozygous missense mutations (Ile41Asn and Gly75Asp) in the gene for serum retinol binding protein (RBP)...
  10. Wallenius V, Elias E, Bergstrom G, Zetterberg H, Behre C. The lipocalins retinol-binding protein-4, lipocalin-2 and lipocalin-type prostaglandin D2-synthase correlate with markers of inflammatory activity, alcohol intake and blood lipids, but not with insulin sensitivity in metabolically healthy 58-year-old. Exp Clin Endocrinol Diabetes. 2011;119:75-80 pubmed publisher
    The lipocalins retinol-binding protein (RBP)-4, lipocalin-2 and lipocalin-type prostaglandin D-synthase (L-PGDS) have been suggested to mediate obesity-associated insulin resistance and other metabolic co-morbidities...

Detail Information

Publications62

  1. Toruner F, Altinova A, Akturk M, Kaya M, Arslan E, Bukan N, et al. The relationship between adipocyte fatty acid binding protein-4, retinol binding protein-4 levels and early diabetic nephropathy in patients with type 2 diabetes. Diabetes Res Clin Pract. 2011;91:203-7 pubmed publisher
    Adipocyte fatty acid binding protein-4 (A-FABP4) and retinol binding protein-4 (RBP4) have recently been linked to type 2 diabetes mellitus (DM)...
  2. Salgado Somoza A, Teijeira Fernandez E, Rubio J, Couso E, Gonzalez Juanatey J, Eiras S. Coronary artery disease is associated with higher epicardial retinol-binding protein 4 (RBP4) and lower glucose transporter (GLUT) 4 levels in epicardial and subcutaneous adipose tissue. Clin Endocrinol (Oxf). 2012;76:51-8 pubmed publisher
    Retinol-binding protein 4 (RBP4), produced by adipocytes and hepatocytes, contributes to an unfavourable lipid profile and insulin resistance, which can contribute to the development of coronary artery disease (CAD)...
  3. Naylor H, Newcomer M. The structure of human retinol-binding protein (RBP) with its carrier protein transthyretin reveals an interaction with the carboxy terminus of RBP. Biochemistry. 1999;38:2647-53 pubmed
    ..or retinol, vitamin A is transported to the target cells as all-trans-retinol bound to retinol-binding protein (RBP)...
  4. Yang Q, Graham T, Mody N, Preitner F, Peroni O, Zabolotny J, et al. Serum retinol binding protein 4 contributes to insulin resistance in obesity and type 2 diabetes. Nature. 2005;436:356-62 pubmed
    ..Here we show, using DNA arrays, that expression of retinol binding protein-4 (RBP4) is elevated in adipose tissue of adipose-Glut4(-/-) mice...
  5. El Mesallamy H, Hamdy N, Zaghloul A, Sallam A. Serum retinol binding protein-4 and neutrophil gelatinase-associated lipocalin are interrelated in pancreatic cancer patients. Scand J Clin Lab Invest. 2012;72:602-7 pubmed publisher
    ..We aimed to determine serum retinol binding protein-4 (RBP-4) and neutophil gelatinase-associated lipocalin (NGAL) levels in pancreatic cancer patients...
  6. Ost A, Danielsson A, Lidén M, Eriksson U, Nystrom F, Stralfors P. Retinol-binding protein-4 attenuates insulin-induced phosphorylation of IRS1 and ERK1/2 in primary human adipocytes. FASEB J. 2007;21:3696-704 pubmed
    ..Animal models and patients with type 2 diabetes exhibit elevated levels of circulating retinol-binding protein (RBP4), and RBP4 can induce insulin resistance in mice. However, little is known about how RBP4 affects insulin signaling...
  7. Biesalski H, Frank J, Beck S, Heinrich F, Illek B, Reifen R, et al. Biochemical but not clinical vitamin A deficiency results from mutations in the gene for retinol binding protein. Am J Clin Nutr. 1999;69:931-6 pubmed
    ..In both siblings, plasma retinol binding protein (RBP) concentrations were below the limit of detection (<0...
  8. Frey S, Spranger J, Henze A, Pfeiffer A, Schweigert F, Raila J. Factors that influence retinol-binding protein 4-transthyretin interaction are not altered in overweight subjects and overweight subjects with type 2 diabetes mellitus. Metabolism. 2009;58:1386-92 pubmed publisher
    Retinol-binding protein 4 (RBP4) is an adipokine bound in plasma to transthyretin (TTR), which prevents its glomerular filtration and subsequent catabolism in the kidney...
  9. Seeliger M, Biesalski H, Wissinger B, Gollnick H, Gielen S, Frank J, et al. Phenotype in retinol deficiency due to a hereditary defect in retinol binding protein synthesis. Invest Ophthalmol Vis Sci. 1999;40:3-11 pubmed
    ..compound heterozygous missense mutations (Ile41Asn and Gly75Asp) in the gene for serum retinol binding protein (RBP)...
  10. Wallenius V, Elias E, Bergstrom G, Zetterberg H, Behre C. The lipocalins retinol-binding protein-4, lipocalin-2 and lipocalin-type prostaglandin D2-synthase correlate with markers of inflammatory activity, alcohol intake and blood lipids, but not with insulin sensitivity in metabolically healthy 58-year-old. Exp Clin Endocrinol Diabetes. 2011;119:75-80 pubmed publisher
    The lipocalins retinol-binding protein (RBP)-4, lipocalin-2 and lipocalin-type prostaglandin D-synthase (L-PGDS) have been suggested to mediate obesity-associated insulin resistance and other metabolic co-morbidities...
  11. Bahr M, Boeker K, Manns M, Tietge U. Decreased hepatic RBP4 secretion is correlated with reduced hepatic glucose production but is not associated with insulin resistance in patients with liver cirrhosis. Clin Endocrinol (Oxf). 2009;70:60-5 pubmed publisher
    ..This study was designed to determine circulating levels and hepatic production of retinol-binding protein 4 (RBP4) in relation to parameters of hepatic and systemic metabolism in patients with liver cirrhosis...
  12. Alapatt P, Guo F, Komanetsky S, Wang S, Cai J, Sargsyan A, et al. Liver retinol transporter and receptor for serum retinol-binding protein (RBP4). J Biol Chem. 2013;288:1250-65 pubmed publisher
    ..in the small intestine, stored in liver, and secreted into circulation bound to serum retinol-binding protein (RBP4)...
  13. Craig R, Chu W, Elbein S. Retinol binding protein 4 as a candidate gene for type 2 diabetes and prediabetic intermediate traits. Mol Genet Metab. 2007;90:338-44 pubmed
    Serum retinol binding protein 4 (RBP4) was recently described as a new adipokine that reduced peripheral and hepatic insulin sensitivity and increased hepatic gluconeogenesis...
  14. Jaconi S, Rose K, Hughes G, Saurat J, Siegenthaler G. Characterization of two post-translationally processed forms of human serum retinol-binding protein: altered ratios in chronic renal failure. J Lipid Res. 1995;36:1247-53 pubmed
    Retinol-binding protein (RBP) is the specific blood carrier for the transport of retinol (vitamin A) to target tissues...