PPARGC1B

Summary

Gene Symbol: PPARGC1B
Description: PPARG coactivator 1 beta
Alias: ERRL1, PERC, PGC-1(beta), PGC1B, peroxisome proliferator-activated receptor gamma coactivator 1-beta, PGC-1-related estrogen receptor alpha coactivator, PPAR-gamma coactivator 1-beta, PPARGC-1-beta, PPARgamma coactivator 1 beta, peroxisome proliferator-activated receptor gamma, coactivator 1 beta
Species: human
Products:     PPARGC1B

Top Publications

  1. Lin J, Puigserver P, Donovan J, Tarr P, Spiegelman B. Peroxisome proliferator-activated receptor gamma coactivator 1beta (PGC-1beta ), a novel PGC-1-related transcription coactivator associated with host cell factor. J Biol Chem. 2002;277:1645-8 pubmed
    ..HCF is shown to bind to both PGC-1alpha and -1beta and augment their transcriptional activity. ..
  2. Kressler D, Schreiber S, Knutti D, Kralli A. The PGC-1-related protein PERC is a selective coactivator of estrogen receptor alpha. J Biol Chem. 2002;277:13918-25 pubmed
    ..Because of its nuclear receptor selectivity, we have termed the new protein PERC (PGC-1 related Estrogen Receptor Coactivator)...
  3. Meirhaeghe A, Crowley V, Lenaghan C, Lelliott C, Green K, Stewart A, et al. Characterization of the human, mouse and rat PGC1 beta (peroxisome-proliferator-activated receptor-gamma co-activator 1 beta) gene in vitro and in vivo. Biochem J. 2003;373:155-65 pubmed
    ..These results suggest that PGC1 beta may play a role in constitutive adrenergic-independent mitochondrial biogenesis. ..
  4. Wirtenberger M, Tchatchou S, Hemminki K, Schmutzhard J, Sutter C, Schmutzler R, et al. Associations of genetic variants in the estrogen receptor coactivators PPARGC1A, PPARGC1B and EP300 with familial breast cancer. Carcinogenesis. 2006;27:2201-8 pubmed
    ..transcription factor, which activates gene expression through recruiting multiple coactivators, such as PPARGC1A, PPARGC1B and EP300...
  5. Patti M, Butte A, Crunkhorn S, Cusi K, Berria R, Kashyap S, et al. Coordinated reduction of genes of oxidative metabolism in humans with insulin resistance and diabetes: Potential role of PGC1 and NRF1. Proc Natl Acad Sci U S A. 2003;100:8466-71 pubmed
    ..in diabetic subjects, expression of both PPAR gamma coactivator 1-alpha and-beta (PGC1-alpha/PPARGC1 and PGC1-beta/PERC), coactivators of NRF-1 and PPAR gamma-dependent transcription, is decreased in both diabetic subjects and family ..
  6. Kressler D, Hock M, Kralli A. Coactivators PGC-1beta and SRC-1 interact functionally to promote the agonist activity of the selective estrogen receptor modulator tamoxifen. J Biol Chem. 2007;282:26897-907 pubmed
    ..Our findings suggest that tamoxifen-induced changes in the ERalpha LBD promote interactions with the coactivator PGC-1beta, which then cooperates with SRC-1 to enable tamoxifen agonism. ..
  7. Nahon K, Doornink F, Straat M, Botani K, Martinez Tellez B, Abreu Vieira G, et al. Effect of sitagliptin on energy metabolism and brown adipose tissue in overweight individuals with prediabetes: a randomised placebo-controlled trial. Diabetologia. 2018;: pubmed publisher
    ..In skeletal muscle, sitagliptin increased mRNA expression of PGC1? (also known as PPARGC1B) (+117%; p?<?0.05), a main controller of mitochondrial oxidative energy metabolism...
  8. Abe M, Xie W, Regan M, King I, Stampfer M, Kantoff P, et al. Single-nucleotide polymorphisms within the antioxidant defence system and associations with aggressive prostate cancer. BJU Int. 2011;107:126-34 pubmed publisher
    ..defence: glutathione peroxidase (GPX1, GPX4), peroxisome proliferator-activated receptor ? coactivator (PPARGC1A, PPARGC1B), SOD1, SOD2, and SOD3, and 'X-ray repair complementing defective repair in Chinese hamster cell 1' (XRCC1)...
  9. De Coster O, Forget P, Moens M, Matic M, Choustoulakis L, Poelaert J. A new minimally invasive technique for lead revision of perc-paddle leads. Acta Neurochir (Wien). 2018;160:831-833 pubmed publisher
    ..An Epiducer can be used to revise the SCS system in a minimal invasive way without a new puncture. Follow-up study of this technique as well as others for revising an SCS system should be encouraged and used in comparison study. ..

More Information

Publications121 found, 100 shown here

  1. Sweeney T, Suliman H, Hollingsworth J, Welty Wolf K, Piantadosi C. A toll-like receptor 2 pathway regulates the Ppargc1a/b metabolic co-activators in mice with Staphylococcal aureus sepsis. PLoS ONE. 2011;6:e25249 pubmed publisher
    ..This includes the metabolic and mitochondrial biogenesis master co-activators, Ppargc1a (PGC-1?) and Ppargc1b (PGC-1?) in Staphylococcus aureus (S. aureus) sepsis...
  2. Noureldin Y, Fahmy N, Anidjar M, Andonian S. Is there a place for virtual reality simulators in assessment of competency in percutaneous renal access?. World J Urol. 2016;34:733-9 pubmed publisher
    ..PCA competency of each participant was assessed objectively by performing task 4 on the PERC Mentorâ„¢ simulator, where they had to correctly access and pop 7 balloons in 7 different renal calyces and ..
  3. Beckford R, Howard S, Das S, Farmer A, Campagna S, Yu J, et al. Maternal consumption of fish oil programs reduced adiposity in broiler chicks. Sci Rep. 2017;7:13129 pubmed publisher
    ..adipocyte profile was paralleled by upregulated expression of the adipogenic regulator PPARG and its co-activator PPARGC1B, and reduced expression of LPL...
  4. Huss J, Kopp R, Kelly D. Peroxisome proliferator-activated receptor coactivator-1alpha (PGC-1alpha) coactivates the cardiac-enriched nuclear receptors estrogen-related receptor-alpha and -gamma. Identification of novel leucine-rich interaction motif within PGC-1alpha. J Biol Chem. 2002;277:40265-74 pubmed
  5. Akhmetov I, Popov D, Missina S, Vinogradova O, Rogozkin V. [The analysis of PPARGC1B gene polymorphism in athletes]. Ross Fiziol Zh Im I M Sechenova. 2009;95:1247-53 pubmed
    ..investigate allelic distribution of the peroxisome proliferator-activated receptor gamma coactivator 1beta gene (PPARGC1B; Ala203Pro polymorphism) in athletes (n = = 1535) and controls (n = 1113), and to find interrelation between ..
  6. Bozarth A, Bajaj N, Wessling M, Keffer D, Jallu S, Salzman G. Evaluation of the pulmonary embolism rule-out criteria in a retrospective cohort at an urban academic hospital. Am J Emerg Med. 2015;33:483-7 pubmed publisher
    The pulmonary embolism rule-out criteria (PERC) is an 8-variable clinical decision rule that identifies patients at low risk for pulmonary embolism (PE) to prevent unnecessary diagnostic testing in the evaluation of suspected PE in the ..
  7. Bialy L, Plint A, Zemek R, Johnson D, Klassen T, Osmond M, et al. Pediatric Emergency Research Canada: Origins and Evolution. Pediatr Emerg Care. 2018;34:138-144 pubmed publisher
    ..The success of Pediatric Emergency Research Canada (PERC) is described in terms of advancing the pediatric emergency medicine agenda, grant funding, peer-reviewed ..
  8. Brinkmann G, Norvang V, Norli E, Grøvle L, Haugen A, Lexberg A, et al. Treat to target strategy in early rheumatoid arthritis versus routine care - A comparative clinical practice study. Semin Arthritis Rheum. 2018;: pubmed publisher
    ..The T2T cohort included 293 patients (mean (SD) age 54 (13) years, 66% females, disease duration median (25,75 perc) 98 (57,164) days) and the routine care cohort 392 patients (age 54 (13) years, 68% females, 4 (0,30) days since ..
  9. Hirose T, Tanaka Y, Tanaka A, Sakai H, Sasaki Y, Shinohara N, et al. PD-L1/PD-L2-expressing B-1 cells inhibit alloreactive T cells in mice. PLoS ONE. 2017;12:e0178765 pubmed publisher
    ..Either splenic B cells, peritoneal cavity (PerC) B cells, or non-B cells from Balb/c mice were intravenously injected into B6 mice...
  10. Zhai N, Sun C, Gu W, He X, Shan A, Sun H, et al. Resistance to high-fat diet-induced obesity in male heterozygous Pprc1 knockout mice. Endocr J. 2015;62:633-44 pubmed publisher
    ..Other than the well-characterized Pgc1a and Pgc1b that act as regulators of mitochondrial biogenesis and oxidative metabolism, the function of Pprc1 in vivo is ..
  11. Hennelly K, Baskin M, Monuteuax M, Hudgins J, Kua E, Commeree A, et al. Detection of Pulmonary Embolism in High-Risk Children. J Pediatr. 2016;178:214-218.e3 pubmed publisher
    ..We evaluated the test characteristics of the Wells criteria and Pulmonary Embolism Rule-out Criteria (PERC) low-risk rule and used recursive partition analysis to derive a clinical decision rule...
  12. Sun D, Sahu B, Gao S, Schur R, Vaidya A, Maeda A, et al. Targeted Multifunctional Lipid ECO Plasmid DNA Nanoparticles as Efficient Non-viral Gene Therapy for Leber's Congenital Amaurosis. Mol Ther Nucleic Acids. 2017;7:42-52 pubmed publisher
    ..because of their intrinsic properties of pH-sensitive amphiphilic endosomal escape and reductive cytosolic release (PERC)...
  13. Kline J, Ellison A, Kanis J, Pike J, Hall C. Evaluation of the pulmonary embolism rule out criteria (PERC rule) in children evaluated for suspected pulmonary embolism. Thromb Res. 2018;168:1-4 pubmed publisher
    The pulmonary embolism rule out criteria (PERC) reliably predicts a low probability of PE in adults. We examine the diagnostic accuracy of the objective components of the PERC rule in children previously tested for PE...
  14. Nan H, Kraft P, Qureshi A, Guo Q, Chen C, Hankinson S, et al. Genome-wide association study of tanning phenotype in a population of European ancestry. J Invest Dermatol. 2009;129:2250-7 pubmed publisher
    ..Overall, these tanning ability-related loci are similar to the hair color-related loci previously reported in the GWAS of hair color. ..
  15. Kripke D, Kline L, Nievergelt C, Murray S, Shadan F, Dawson A, et al. Genetic variants associated with sleep disorders. Sleep Med. 2015;16:217-24 pubmed publisher
    ..In peroxisome proliferator-activated receptor gamma, coactivator 1 beta (PPARGC1B), rs6888451 was associated with several markers of obstructive sleep apnea...
  16. Andreadou I, Bibli S, Mastromanolis E, Zoga A, Efentakis P, Papaioannou N, et al. Transient carotid ischemia as a remote conditioning stimulus for myocardial protection in anesthetized rabbits: Insights into intracellular signaling. Int J Cardiol. 2015;184:140-51 pubmed publisher
    We investigated the effectiveness of perconditioning (Perc) applied at different time points along with the role of RISK, SAFE, STAT5 and eNOS pathways. Anesthetized rabbits were subjected to 30-min ischemia/3-hour reperfusion...
  17. Goldman N, Valiuskyte K, Londregan J, Swider A, Somerville J, Riggs J. Macrophage regulation of B cell proliferation. Cell Immunol. 2017;314:54-62 pubmed publisher
    ..We model the TME by culturing peritoneal cavity (PerC) cells that naturally have a high macrophage to lymphocyte ratio...
  18. Zhu L, Huang Q, Xie Z, Kang M, Ding H, Chen B, et al. PPARGC1A rs3736265 G>A polymorphism is associated with decreased risk of type 2 diabetes mellitus and fasting plasma glucose level. Oncotarget. 2017;8:37308-37320 pubmed publisher
    ..g. PPARGC1A and PPARGC1B) are key agents in the development and pathophysiology of type 2 diabetes mellitus (T2DM)...
  19. Liesa M, Borda d Agua B, Medina Gomez G, Lelliott C, Paz J, Rojo M, et al. Mitochondrial fusion is increased by the nuclear coactivator PGC-1beta. PLoS ONE. 2008;3:e3613 pubmed publisher
    ..In addition, we describe a novel role of PGC-1beta in mitochondrial physiology, namely the control of mitochondrial fusion mainly through Mfn2. ..
  20. Petrov P, Palou A, Bonet M, Ribot J. Cell-Autonomous Brown-Like Adipogenesis of Preadipocytes From Retinoblastoma Haploinsufficient Mice. J Cell Physiol. 2016;231:1941-52 pubmed publisher
    ..conditions increased glucose uptake and an enhanced expression of brown adipocyte-related genes (Pparg, Ppargc1a, Ppargc1b, Prdm16, Cpt1b) but not of purported beige/brite transcriptional markers (Cd137, Tmem26, Tbx1, Slc27a1, Hoxc9, ..
  21. Cichocki J, Furuya S, Konganti K, Luo Y, McDonald T, Iwata Y, et al. Impact of Nonalcoholic Fatty Liver Disease on Toxicokinetics of Tetrachloroethylene in Mice. J Pharmacol Exp Ther. 2017;361:17-28 pubmed publisher
    ..We examined the effect of NAFLD on toxicokinetics of tetrachloroethylene (PERC), a ubiquitous environmental contaminant that requires metabolic activation to induce adverse health effects...
  22. Petr M, Stastny P, Zajac A, Tufano J, Maciejewska Skrendo A. The Role of Peroxisome Proliferator-Activated Receptors and Their Transcriptional Coactivators Gene Variations in Human Trainability: A Systematic Review. Int J Mol Sci. 2018;19: pubmed publisher
    ..receptors (PPARA, PPARG, PPARD) and their transcriptional coactivators' (PPARGC1A, PPARGC1B) gene polymorphisms have been associated with muscle morphology, oxygen uptake, power output and endurance ..
  23. He Z, Hu Y, Li Y, Gong L, Cieszczyk P, Maciejewska Karlowska A, et al. PGC-related gene variants and elite endurance athletic status in a Chinese cohort: a functional study. Scand J Med Sci Sports. 2015;25:184-95 pubmed publisher
    ..Genotype distributions of 133 SNPs in PPARGC1A, PPARGC1B, PPRC1, TFAM, TFB1M, TFB2M, NRF1, GABPA, GABPB1, ERRα, and SIRT1 genes were compared between 235 elite Chinese ..
  24. Teixeira N, Rojas T, da Silveira W, Matheus Guimarães C, Silva N, Scaletsky I. Genetic analysis of enteropathogenic Escherichia coli (EPEC) adherence factor (EAF) plasmid reveals a new deletion within the EAF probe sequence among O119 typical EPEC strains. BMC Microbiol. 2015;15:200 pubmed publisher
    ..22 of which belonged to O119 serogroup, presented a 1652 pb deletion in the region between 1093-bp downstream perC and 616-bp of the EAF fragment. The bfpA, bfpG, and per genes were found in all typical strains...
  25. Dias C, Menezes H, Cardeal Z. Use of exhaled air as an improved biomonitoring method to assess perchloroethylene short-term exposure. Environ Res. 2017;156:108-112 pubmed publisher
    This paper shows the use of exhaled air as a biomonitoring method to assess perchloroethylene (PERC) environmental and occupational exposure...
  26. Mullerova D, Pesta M, Dvorakova J, Cedíková M, Kulda V, Dvorak P, et al. Polychlorinated biphenyl 153 in lipid medium modulates differentiation of human adipocytes. Physiol Res. 2017;66:653-662 pubmed
    ..in lipid vehicle was associated with down regulation of key master genes of adipogenesis: PPARgamma, SREBP-1, PPARGC1B, and PLIN2 during the whole process of differentiation; and with increased Akt and decreased Phospho-Akt protein ..
  27. Wang L, Liu Q, Li F, Qiu J, Fan H, Ma H, et al. Apoptosis induced by PGC-1? in breast cancer cells is mediated by the mTOR pathway. Oncol Rep. 2013;30:1631-8 pubmed publisher
    ..These results provide new evidence that cell apoptosis is orchestrated by the balance between several signaling pathways, and that PGC-1? takes part in these events in breast cancer cells mediated by the mTOR signaling pathway. ..
  28. Kauvar D, Martin E, Givens M. Thirty-Day Outcomes after Elective Percutaneous or Open Endovascular Repair of Abdominal Aortic Aneurysms. Ann Vasc Surg. 2016;31:46-51 pubmed publisher
    ..surgical exposure of the femoral artery for access (OPEN) were compared with those completed without such exposure (PERC)...
  29. Troynikov O, Watson C, Jadhav A, Nawaz N, Kettlewell R. Towards sustainable and safe apparel cleaning methods: A review. J Environ Manage. 2016;182:252-264 pubmed publisher
    Perchloroethylene (PERC) is a compound commonly used as a solvent in dry cleaning, despite its severe health and environmental impacts...
  30. Kumazoe M, Takai M, Hiroi S, Takeuchi C, Kadomatsu M, Nojiri T, et al. The FOXO3/PGC-1? signaling axis is essential for cancer stem cell properties of pancreatic ductal adenocarcinoma. J Biol Chem. 2017;292:10813-10823 pubmed publisher
    ..This suggests that cGMP induction and PGC-1? inhibition represent potential strategies for treating patients with pancreatic ductal adenocarcinoma. ..
  31. Ma L, Qiu H, Chen Z, Li L, Zeng Y, Luo J, et al. miR-25 modulates triacylglycerol and lipid accumulation in goat mammary epithelial cells by repressing PGC-1beta. J Anim Sci Biotechnol. 2018;9:48 pubmed publisher
    ..Taken together, our results show miR-25 is potentially involved in lipid metabolism and we reveal the function of the miR-25/PGC-1beta regulatory axis during lactation. ..
  32. Madsen T, Jedick R, Teeples T, Carlson M, Steenblik J. Impact of altitude-adjusted hypoxia on the Pulmonary Embolism Rule-out Criteria. Am J Emerg Med. 2018;: pubmed publisher
    The Pulmonary Embolism Rule-out Criteria (PERC) defines hypoxia as an oxygen saturation (O2 sat)?<?95%...
  33. Strekalova T, Costa Nunes J, Veniaminova E, Kubatiev A, Lesch K, Chekhonin V, et al. Insulin receptor sensitizer, dicholine succinate, prevents both Toll-like receptor 4 (TLR4) upregulation and affective changes induced by a high-cholesterol diet in mice. J Affect Disord. 2016;196:109-16 pubmed publisher
    ..measures of anxiety/depression, and Tlr4 and peroxisome-proliferator-activated-receptor-gamma coactivator-1b (PPARGC1b) expression...
  34. Hsu C, Yang C, Wang Y, Huang C, Lien S, Kung C, et al. Low Cost Local Contact Opening by Using Polystyrene Spheres Spin-Coating Method for PERC Solar Cells. Materials (Basel). 2016;9: pubmed publisher
    The passivated emitter and rear cell (PERC) concept is one of the most promising technologies for increasing crystalline silicon solar cell efficiency...
  35. Frizell A, Fogel N, Steenblik J, Carlson M, Bledsoe J, Madsen T. Prevalence of pulmonary embolism in patients presenting to the emergency department with syncope. Am J Emerg Med. 2018;36:253-256 pubmed publisher
    ..with a PE at the time of the ED visit or during the follow-up period were Pulmonary Embolism Rule Out Criteria (PERC) positive and reported shortness of breath in the ED...
  36. Drescher M, Fried J, Brass R, Medoro A, Murphy T, Delgado J. Knowledge Translation of the PERC Rule for Suspected Pulmonary Embolism: A Blueprint for Reducing the Number of CT Pulmonary Angiograms. West J Emerg Med. 2017;18:1091-1097 pubmed publisher
    ..We studied a department-endorsed, evidence-based clinical protocol that included the PE rule-out criteria (PERC) rule, multi-modal education using principles of knowledge translation (KT), and clinical decision support embedded ..
  37. Hara K, Tobe K, Okada T, Kadowaki H, Akanuma Y, Ito C, et al. A genetic variation in the PGC-1 gene could confer insulin resistance and susceptibility to Type II diabetes. Diabetologia. 2002;45:740-3 pubmed
    ..The Thr394Thr - Gly482Ser haplotype was associated with Type II diabetes (p = 0.00003). CONCLUSION/INTERPRETATION. The results of this study suggested that the PGC-1 gene might be implicated in the pathogenesis of Type II diabetes. ..
  38. Victorino V, Barroso W, Assunção A, Cury V, Jeremias I, Petroni R, et al. PGC-1β regulates HER2-overexpressing breast cancer cells proliferation by metabolic and redox pathways. Tumour Biol. 2016;37:6035-44 pubmed publisher
    ..In conclusion, we show an association of HER2-overexpression and PGC-1β. PGC-1β knockdown impairs HER2-overexpressing cells proliferation acting on ERRα signaling, metabolism, and redox balance. ..
  39. Wood M, Goldman N, DePierri K, Somerville J, Riggs J. Erythropoietin increases macrophage-mediated T cell suppression. Cell Immunol. 2016;306-307:17-24 pubmed publisher
    ..the high macrophage to lymphocyte ratio found in tumor microenvironments (TMEs) by culturing peritoneal cavity (PerC) cells that naturally have a high macrophage to T cell ratio...
  40. Valli H, Ahmad S, Fraser J, Jeevaratnam K, Huang C. Pro-arrhythmic atrial phenotypes in incrementally paced murine Pgc1?-/- hearts: effects of age. Exp Physiol. 2017;102:1619-1634 pubmed publisher
    ..aged (>52 week) wild-type (WT) and peroxisome proliferative activated receptor, gamma, coactivator 1 beta (Ppargc1b)-deficient (Pgc1?-/- ) Langendorff-perfused hearts, previously used to model mitochondrial energetic ..
  41. Shiraki T, Sakai N, Kanaya E, Jingami H. Activation of orphan nuclear constitutive androstane receptor requires subnuclear targeting by peroxisome proliferator-activated receptor gamma coactivator-1 alpha. A possible link between xenobiotic response and nutritional state. J Biol Chem. 2003;278:11344-50 pubmed
    ..These results indicate that PGC-1 alpha mediates the ligand-independent activation of CAR by means of subnuclear targeting through the RS domain of PGC-1 alpha. ..
  42. Lee S, Jang A, Woo Park S, Park J, Kim Y, Uh S, et al. Genetic effect of single-nucleotide polymorphisms in the PPARGC1B gene on airway hyperreactivity in asthmatic patients. Clin Exp Allergy. 2011;41:1533-44 pubmed publisher
    Peroxisome proliferator-activated receptor gamma coactivator 1 beta (PPARGC1B) is a co-activator for intracellular receptors such as the estrogen receptor, PPAR, and glucocorticoid receptor, which are involved in asthma development...
  43. Riehle C, Abel E. PGC-1 proteins and heart failure. Trends Cardiovasc Med. 2012;22:98-105 pubmed publisher
    ..Here, we discuss the regulation of PGC-1 proteins under conditions of pressure overload hypertrophy and heart failure. ..
  44. Cho Y, Hazen B, Russell A, Kralli A. Peroxisome proliferator-activated receptor ? coactivator 1 (PGC-1)- and estrogen-related receptor (ERR)-induced regulator in muscle 1 (Perm1) is a tissue-specific regulator of oxidative capacity in skeletal muscle cells. J Biol Chem. 2013;288:25207-18 pubmed publisher
    ..Elucidating the function of Perm1 may enable novel approaches for the treatment of disorders with compromised skeletal muscle bioenergetics, such as mitochondrial myopathies and age-related/disease-associated muscle atrophies. ..
  45. Galmés Pascual B, Nadal Casellas A, Bauzá Thorbrügge M, Sbert Roig M, Garcia Palmer F, Proenza A, et al. 17?-estradiol improves hepatic mitochondrial biogenesis and function through PGC1B. J Endocrinol. 2017;232:297-308 pubmed
    ..mitochondrial biogenesis and function, but little is known about the different contribution of hepatic PGC1A and PGC1B in these processes...
  46. Goldman N, Lomakova Y, Londregan J, Bucknum A, DePierri K, Somerville J, et al. High macrophage PD-L1 expression not responsible for T cell suppression. Cell Immunol. 2018;324:50-58 pubmed publisher
    ..Peritoneal cavity (PerC) cell culture reproduces key features of TMEs as lymphocyte proliferation is suppressed by PerC macrophages (MÏ•..
  47. Kelly C, Agy C, Carlson M, Steenblik J, Bledsoe J, Hartsell S, et al. Family history of venous thromboembolism predicts the diagnosis of acute pulmonary embolism in the emergency department. Am J Emerg Med. 2018;36:1550-1554 pubmed publisher
    ..2% vs. 1.6% (p?=?0.009). 82.3% of patients were Pulmonary Embolism Rule-out Criteria (PERC) positive, and among PERC-positive patients, those with a family history of VTE were more likely to be diagnosed ..
  48. Srivastava S, Diaz F, Iommarini L, Aure K, Lombes A, Moraes C. PGC-1alpha/beta induced expression partially compensates for respiratory chain defects in cells from patients with mitochondrial disorders. Hum Mol Genet. 2009;18:1805-12 pubmed publisher
    ..These results reinforce the concept that increased mitochondrial biogenesis is a promising venue for the treatment of mitochondrial diseases. ..
  49. Browne G, Dragon J, Hong D, Messier T, Gordon J, Farina N, et al. MicroRNA-378-mediated suppression of Runx1 alleviates the aggressive phenotype of triple-negative MDA-MB-231 human breast cancer cells. Tumour Biol. 2016;37:8825-39 pubmed publisher
    ..of Runx1 in late-stage breast cancer cells resulted in increased expression of both the miR-378 host gene PPARGC1B and pre-miR-378, suggesting a feedback loop...
  50. Freund Y, Rousseau A, Guyot Rousseau F, Claessens Y, Hugli O, Sanchez O, et al. PERC rule to exclude the diagnosis of pulmonary embolism in emergency low-risk patients: study protocol for the PROPER randomized controlled study. Trials. 2015;16:537 pubmed publisher
    ..The Pulmonary Embolism Rule-out Criteria (PERC) is an eight-item block of clinical criteria that can identify patients who can safely be discharged from the ED ..
  51. Booker M, Johnson J. Optimizing CT Pulmonary Angiogram Utilization in a Community Emergency Department: A Pre- and Postintervention Study. J Am Coll Radiol. 2017;14:65-71 pubmed publisher
    ..2% in the pre- and postintervention groups, respectively. Similarly, the workup of patients based on retrospective PERC and Wells-score criteria did not significantly improve after the intervention...
  52. Handschin C, Spiegelman B. Peroxisome proliferator-activated receptor gamma coactivator 1 coactivators, energy homeostasis, and metabolism. Endocr Rev. 2006;27:728-35 pubmed
    ..Recent studies have elucidated the function of the PGC-1 coactivators in different tissues and have highlighted the implications of PGC-1 dysregulation in diseases such as diabetes, obesity, cardiomyopathy, or neurodegeneration. ..
  53. Oelsner K, Guo Y, To S, Non A, Barkin S. Maternal BMI as a predictor of methylation of obesity-related genes in saliva samples from preschool-age Hispanic children at-risk for obesity. BMC Genomics. 2017;18:57 pubmed publisher
    ..Furthermore, eight of the 17 CpG sites reside in genes (FSTL1, SORCS2, NRF1, DLC1, PPARGC1B, CHN2, NXPH1) that have prior known associations with obesity, diabetes, and the insulin pathway...
  54. Alix Panabières C, Cayrefourcq L, Mazard T, Maudelonde T, Assenat E, Assou S. Molecular Portrait of Metastasis-Competent Circulating Tumor Cells in Colon Cancer Reveals the Crucial Role of Genes Regulating Energy Metabolism and DNA Repair. Clin Chem. 2017;63:700-713 pubmed publisher
    ..receptor ? coactivator 1A (PPARGC1A), peroxisome proliferator-activated receptor ? coactivator 1B (PPARGC1B), fatty acid binding protein 1 (FABP1), aldehyde dehydrogenase 3 family member A1 (ALDH3A1)], ..
  55. Kline J. Diagnosis and Exclusion of Pulmonary Embolism. Thromb Res. 2018;163:207-220 pubmed publisher
    ..for PE or a Wells score<2, they can reasonably exclude PE with the Pulmonary Embolism Rule out Criteria (PERC rule)...
  56. Wible R, Tran Q, Fathima S, Sutter C, Kensler T, Sutter T. Pharmacogenomics of Chemically Distinct Classes of Keap1-Nrf2 Activators Identify Common and Unique Gene, Protein, and Pathway Responses In Vivo. Mol Pharmacol. 2018;93:297-308 pubmed publisher
    ..Although both compounds modify Keap1 to affect canonical cytoprotective gene expression, additional unique sets of Nrf2-dependent genes were regulated by each agent with enrichment of selective metabolic pathways. ..
  57. Knutti D, Kaul A, Kralli A. A tissue-specific coactivator of steroid receptors, identified in a functional genetic screen. Mol Cell Biol. 2000;20:2411-22 pubmed
    ..Our findings suggest a regulatory function for hPGC-1 as a tissue-specific coactivator for a subset of nuclear receptors. ..
  58. Shoag J, Haq R, Zhang M, Liu L, Rowe G, Jiang A, et al. PGC-1 coactivators regulate MITF and the tanning response. Mol Cell. 2013;49:145-57 pubmed publisher
    ..These data identify PGC-1 coactivators as regulators of human tanning. ..
  59. Wen Y, Hao J, Xiao X, Wang W, Guo X, Lin W, et al. PPARGC1B gene is associated with Kashin-Beck disease in Han Chinese. Funct Integr Genomics. 2016;16:459-63 pubmed publisher
    ..The genetic basis of KBD remains elusive now. To investigate the relationship between PPARGC1B gene polymorphism and KBD, we conducted a two-stage association study using 2743 unrelated Han Chinese subjects...
  60. Pesce V, Nicassio L, Fracasso F, Musicco C, Cantatore P, Gadaleta M. Acetyl-L-carnitine activates the peroxisome proliferator-activated receptor-? coactivators PGC-1?/PGC-1?-dependent signaling cascade of mitochondrial biogenesis and decreases the oxidized peroxiredoxins content in old rat liver. Rejuvenation Res. 2012;15:136-9 pubmed publisher
    ..Furthermore, a remarkable decline of Drp1 and of Mfn2 proteins is reported here for the first time, suggesting a reduced mitochondrial dynamics in aging liver with no effect of ALCAR treatment. ..
  61. Li X, Liu H, Amos C, Lee J, Thomas N, Wei Q, et al. A PGC1? genetic variant associated with nevus count and melanoma mortality. Int J Cancer. 2017;141:1066-1067 pubmed publisher
  62. Luo Y, Cichocki J, McDonald T, Rusyn I. Simultaneous detection of the tetrachloroethylene metabolites S-(1,2,2-trichlorovinyl) glutathione, S-(1,2,2-trichlorovinyl)-L-cysteine, and N-acetyl-S-(1,2,2-trichlorovinyl)-L-cysteine in multiple mouse tissues via ultra-high performance liquid chro. J Toxicol Environ Health A. 2017;80:513-524 pubmed publisher
    Tetrachloroethylene (perchloroethylene; PERC) is a high-production volume chemical and ubiquitous environmental contaminant that is hazardous to human health...
  63. Esterbauer H, Oberkofler H, Krempler F, Patsch W. Human peroxisome proliferator activated receptor gamma coactivator 1 (PPARGC1) gene: cDNA sequence, genomic organization, chromosomal localization, and tissue expression. Genomics. 1999;62:98-102 pubmed
    ..Hence, PPARGC1 expression might influence insulin sensitivity as well as energy expenditure, thereby contributing to the development and pathophysiology of human obesity. ..
  64. Ek J, Andersen G, Urhammer S, Gaede P, Drivsholm T, Borch Johnsen K, et al. Mutation analysis of peroxisome proliferator-activated receptor-gamma coactivator-1 (PGC-1) and relationships of identified amino acid polymorphisms to Type II diabetes mellitus. Diabetologia. 2001;44:2220-6 pubmed
    ..0007). No interaction between this variant and the Pro12Ala polymorphism of PPAR-gamma2 was observed. A widespread Gly482Ser polymorphism of PGC-1 is associated with a 1.34 genotype relative risk of Type II diabetes. ..
  65. Mellies J, Platenkamp A, Osborn J, Ben Avi L. PerC Manipulates Metabolism and Surface Antigens in Enteropathogenic Escherichia coli. Front Cell Infect Microbiol. 2017;7:32 pubmed publisher
    ..The pEAF plasmid encodes an attachment factor as well as a regulatory operon, perABC. PerC, a poorly understood regulator, was previously shown to regulate expression of the type III secretion system ..
  66. Lacquemant C, Chikri M, Boutin P, Samson C, Froguel P. No association between the G482S polymorphism of the proliferator-activated receptor-gamma coactivator-1 (PGC-1) gene and Type II diabetes in French Caucasians. Diabetologia. 2002;45:602-3; author reply 604 pubmed
  67. Yao Z, Jones A, Fassone E, Sweeney M, Lebiedzinska M, Suski J, et al. PGC-1? mediates adaptive chemoresistance associated with mitochondrial DNA mutations. Oncogene. 2013;32:2592-600 pubmed publisher
    ..Altogether, our results suggest that partial respiratory chain defects because of mtDNA mutations can lead to compensatory upregulation of nuclear transcriptional co-regulators, in turn mediating resistance to genotoxic stress. ..
  68. Martínez Nava G, Burguete Garcia A, Lopez Carrillo L, Hernandez Ramirez R, Madrid Marina V, Cebrian M. PPAR? and PPARGC1B polymorphisms modify the association between phthalate metabolites and breast cancer risk. Biomarkers. 2013;18:493-501 pubmed publisher
    ..To investigate whether PPAR? and PPARGC1B polymorphisms modulate these associations. 208 BC cases were age-matched with 220 population controls...
  69. Chang H, Lee S, Lee J, Park J, Chung I, Park C. Functional Characterization of Exonic Variants of the PPARGC1B Gene in Coregulation of Estrogen Receptor Alpha. DNA Cell Biol. 2016;35:314-21 pubmed publisher
    Peroxisome proliferator-activated receptor gamma coactivator 1 beta (PPARGC1B) is a coactivator of estrogen receptor (ER)? and ER?...
  70. Cichocki J, Furuya S, Venkatratnam A, McDonald T, Knap A, Wade T, et al. Characterization of Variability in Toxicokinetics and Toxicodynamics of Tetrachloroethylene Using the Collaborative Cross Mouse Population. Environ Health Perspect. 2017;125:057006 pubmed publisher
    ..For most environmental pollutants, including perchloroethylene (PERC), experimental data are lacking, resulting in default assumptions being used to account for variability in ..
  71. Cheasley R, Keller C, Setton E. Lifetime excess cancer risk due to carcinogens in food and beverages: Urban versus rural differences in Canada. Can J Public Health. 2017;108:e288-e295 pubmed publisher
    ..Contaminant concentrations for arsenic, benzene, lead, polychlorinated biphenyls (PCBs) and tetrachloroethylene (PERC) were derived from government dietary studies...
  72. Srivastava S, Barrett J, Moraes C. PGC-1alpha/beta upregulation is associated with improved oxidative phosphorylation in cells harboring nonsense mtDNA mutations. Hum Mol Genet. 2007;16:993-1005 pubmed
    ..In conclusion, upregulation of PGC-1alpha and PGC-1beta in the colorectal tumor cells can be part of an adaptation mechanism to help overcome the severe consequences of mtDNA mutations on OXPHOS. ..
  73. Gao M, Wang J, Lu N, Fang F, Liu J, Wong C. Mitogen-activated protein kinase kinases promote mitochondrial biogenesis in part through inducing peroxisome proliferator-activated receptor ? coactivator-1? expression. Biochim Biophys Acta. 2011;1813:1239-44 pubmed publisher
    ..Thus, we conclude that mitogen-activated protein kinase kinases direct mitochondrial biogenesis through selectively inducing PGC-1? expression. ..
  74. Liu J, Lian Z, Xiao Y, Shi L, Chai W, Wang Y. Analysis of clinical indexes and RUNX3, TBKBP1, PPARGC1B polymorphisms in Chinese Han patients with ankylosing spondylitis. Genet Test Mol Biomarkers. 2015;19:37-43 pubmed publisher
    ..kinase 1 binding protein (TBKBP1), and peroxisome proliferator-activated receptor-gamma coactivator 1 beta (PPARGC1B) have recently been found to be associated with susceptibility to AS in patients of Western European descent...
  75. Litz C, Farach S, Fernández A, Elliott R, Dolan J, Patel N, et al. Percutaneous ultrasound-guided vs. intraoperative rectus sheath block for pediatric umbilical hernia repair: A randomized clinical trial. J Pediatr Surg. 2017;52:901-906 pubmed publisher
    Regional anesthesia is commonly used in children. Our hypothesis was that percutaneous ultrasound-guided (PERC) rectus sheath blocks would result in lower postoperative pain scores compared to intraoperative (IO) rectus sheath blocks ..
  76. Sen H, Seckiner I, Bayrak O, Dogan K, Erturhan S. A comparison of micro-PERC and retrograde intrarenal surgery results in pediatric patients with renal stones. J Pediatr Urol. 2017;13:619.e1-619.e5 pubmed publisher
    ..A total of 48 pediatric patients, who underwent RIRS or micro-PERC for pediatric kidney stone disease, were retrospectively analyzed...
  77. Hentschke M, Süsens U, Borgmeyer U. PGC-1 and PERC, coactivators of the estrogen receptor-related receptor gamma. Biochem Biophys Res Commun. 2002;299:872-9 pubmed
    ..We found that the expression of the coactivators PGC-1 (PGC-1alpha) and PERC (PGC-1beta) in mammalian cells augmented potently the transcriptional activation by ERRgamma...
  78. Rubio Infante N, Ilhuicatzi Alvarado D, Torres Martínez M, Reyes Grajeda J, Nava Acosta R, González González E, et al. The Macrophage Activation Induced by Bacillus thuringiensis Cry1Ac Protoxin Involves ERK1/2 and p38 Pathways and the Interaction with Cell-Surface-HSP70. J Cell Biochem. 2018;119:580-598 pubmed publisher
    ..csHSP70 also was evaluated in peritoneal-cavity (PerC) macrophages of untreated BALB/c mice, interestingly it was found that the predominant population namely large-..
  79. Andersen G, Wegner L, Yanagisawa K, Rose C, Lin J, Glumer C, et al. Evidence of an association between genetic variation of the coactivator PGC-1beta and obesity. J Med Genet. 2005;42:402-7 pubmed
    ..We studied variation in the coding region of human PPARGC1B in Danish whites and related these variations to the prevalence of obesity and type 2 diabetes in population ..
  80. Staiger H, Staiger K, Haas C, Weisser M, Machicao F, Haring H. Fatty acid-induced differential regulation of the genes encoding peroxisome proliferator-activated receptor-gamma coactivator-1alpha and -1beta in human skeletal muscle cells that have been differentiated in vitro. Diabetologia. 2005;48:2115-8 pubmed
    ..has not been assessed in detail, the aim of this study was to determine whether PPARGC1A (and PPARGC1B) expression is modulated by common plasma fatty acids in human skeletal muscle cells...
  81. Kelly T, Lerin C, Haas W, Gygi S, Puigserver P. GCN5-mediated transcriptional control of the metabolic coactivator PGC-1beta through lysine acetylation. J Biol Chem. 2009;284:19945-52 pubmed publisher
    ..These results suggest that PGC-1beta acetylation by GCN5 might be an important step in the control of glucose and lipid pathways and its dysregulation could contribute to metabolic diseases. ..
  82. Thiepold A, Lorenz N, Foltyn M, Engel A, Divé I, Urban H, et al. Mammalian target of rapamycin complex 1 activation sensitizes human glioma cells to hypoxia-induced cell death. Brain. 2017;140:2623-2638 pubmed publisher
    ..due to higher transcription rates of genes involved in mitochondrial respiratory function including PPARGC1A and PPARGC1B (also known as PGC-1? and -?)...
  83. Gao M, Wang J, Wang W, Liu J, Wong C. Phosphatidylinositol 3-kinase affects mitochondrial function in part through inducing peroxisome proliferator-activated receptor ? coactivator-1? expression. Br J Pharmacol. 2011;162:1000-8 pubmed publisher
    ..PI3K regulates mitochondrial homeostasis in part through PGC-1? and blocking this pathway induces ROS to arrest cell growth at the G? phase. ..
  84. Villegas R, Williams S, Gao Y, Long J, Shi J, Cai H, et al. Genetic variation in the peroxisome proliferator-activated receptor (PPAR) and peroxisome proliferator-activated receptor gamma co-activator 1 (PGC1) gene families and type 2 diabetes. Ann Hum Genet. 2014;78:23-32 pubmed publisher
    ..receptors (PPAR) and the PPAR gamma co-activator 1 (PGC1) gene families (PPARA, PPARG, PPARD, PPARGC1A, and PPARGC1B) are associated with type 2 diabetes (T2D) risk...
  85. Wolfrum C, Stoffel M. Coactivation of Foxa2 through Pgc-1beta promotes liver fatty acid oxidation and triglyceride/VLDL secretion. Cell Metab. 2006;3:99-110 pubmed
    ..These data demonstrate that Foxa2/Pgc-1beta regulate hepatic lipid homeostasis by affecting the clearance rate of fatty acids through oxidation and/or secretion of lipids in response to insulin. ..
  86. Hoeks J, Hesselink M, Russell A, Mensink M, Saris W, Mensink R, et al. Peroxisome proliferator-activated receptor-gamma coactivator-1 and insulin resistance: acute effect of fatty acids. Diabetologia. 2006;49:2419-26 pubmed
    ..065). Lipid infusion decreased PPARGC1A, PPARGC1B and PPARA expression to approximately 61, 77 and approximately 52% of basal values respectively, whereas ..
  87. Shao D, Liu Y, Liu X, Zhu L, Cui Y, Cui A, et al. PGC-1 beta-regulated mitochondrial biogenesis and function in myotubes is mediated by NRF-1 and ERR alpha. Mitochondrion. 2010;10:516-27 pubmed publisher
    ..Taken together, these results confirm the direct interaction of NRF-1 and ERR alpha with PGC-1 beta, and their participation in mitochondrial biogenesis and respiration. ..
  88. Chang W, Jan Wu Y, Chung W, Lee Y, Chin S, Chen T, et al. Genetic variants of PPAR-gamma coactivator 1B augment NLRP3-mediated inflammation in gouty arthritis. Rheumatology (Oxford). 2017;56:457-466 pubmed publisher
    ..receptor-γ, proliferator-activated receptor-γ coactivator 1α ( PPARGC1A ) and 1β ( PPARGC1B ). The association was validated by replication and combined-sample analyses...
  89. Penaloza A, Soulie C, Moumneh T, Delmez Q, Ghuysen A, El Kouri D, et al. Pulmonary embolism rule-out criteria (PERC) rule in European patients with low implicit clinical probability (PERCEPIC): a multicentre, prospective, observational study. Lancet Haematol. 2017;4:e615-e621 pubmed publisher
    The ability of the pulmonary embolism rule-out criteria (PERC) to exclude pulmonary embolism without further testing remains debated outside the USA, especially in the population with suspected pulmonary embolism who have a high ..
  90. Nanthirudjanar T, Furumoto H, Hirata T, Sugawara T. Oxidized eicosapentaenoic acids more potently reduce LXR?-induced cellular triacylglycerol via suppression of SREBP-1c, PGC-1? and GPA than its intact form. Lipids Health Dis. 2013;12:73 pubmed publisher
    ..Therefore, the advantageous effects of OEPAs on cardiovascular diseases might be due to their SREBP-1c, PGC-1? and GPA mediated ameliorating effects. ..
  91. Ling C, Wegner L, Andersen G, Almgren P, Hansen T, Pedersen O, et al. Impact of the peroxisome proliferator activated receptor-gamma coactivator-1beta (PGC-1beta) Ala203Pro polymorphism on in vivo metabolism, PGC-1beta expression and fibre type composition in human skeletal muscle. Diabetologia. 2007;50:1615-20 pubmed
    Peroxisome proliferator activated receptor-gamma coactivator-1beta (PGC-1beta, also known as PPARGC1B) expression is reduced in skeletal muscle from patients with type 2 diabetes mellitus and in elderly subjects...
  92. Wang H, Yan X, Ji L, Ji X, Wang P, Guo S, et al. miR-139 Functions as An Antioncomir to Repress Glioma Progression Through Targeting IGF-1 R, AMY-1, and PGC-1β. Technol Cancer Res Treat. 2017;16:497-511 pubmed publisher
    ..Taken together, these findings suggested miR-139 acted as a favorable factor against gliomas progression and uncovered a novel regulatory mechanism, which may provide a new evidenced prognostic marker and therapeutic target for gliomas. ..