PEX19

Summary

Gene Symbol: PEX19
Description: peroxisomal biogenesis factor 19
Alias: D1S2223E, HK33, PBD12A, PMP1, PMPI, PXF, PXMP1, peroxisomal biogenesis factor 19, 33 kDa housekeeping protein, housekeeping gene, 33kD, peroxin-19, peroxisomal farnesylated protein
Species: human
Products:     PEX19

Top Publications

  1. Sacksteder K, Jones J, South S, Li X, Liu Y, Gould S. PEX19 binds multiple peroxisomal membrane proteins, is predominantly cytoplasmic, and is required for peroxisome membrane synthesis. J Cell Biol. 2000;148:931-44 pubmed
    ..Here, we show that PEX19 binds a broad spectrum of PMPs, displays saturable PMP binding, and interacts with regions of PMPs required for ..
  2. Sato Y, Shibata H, Nakano H, Matsuzono Y, Kashiwayama Y, Kobayashi Y, et al. Characterization of the interaction between recombinant human peroxin Pex3p and Pex19p: identification of TRP-104 IN Pex3p as a critical residue for the interaction. J Biol Chem. 2008;283:6136-44 pubmed publisher
    ..These findings suggest that the indole ring of Trp-104 directly interacts with Pex19p to facilitate the specific peroxisomal translocation of the Pex19p-PMP complexes. ..
  3. Matsuzaki T, Fujiki Y. The peroxisomal membrane protein import receptor Pex3p is directly transported to peroxisomes by a novel Pex19p- and Pex16p-dependent pathway. J Cell Biol. 2008;183:1275-86 pubmed publisher
    ..Based on these novel findings, we suggest a model for the import of PMPs that provides new insights into the molecular mechanisms underlying the biogenesis of peroxisomes and its regulation involving Pex3p, Pex19p, and Pex16p. ..
  4. Halbach A, Landgraf C, Lorenzen S, Rosenkranz K, Volkmer Engert R, Erdmann R, et al. Targeting of the tail-anchored peroxisomal membrane proteins PEX26 and PEX15 occurs through C-terminal PEX19-binding sites. J Cell Sci. 2006;119:2508-17 pubmed
    ..Its C-terminal-targeting signal contains two binding sites for PEX19, the import receptor for several peroxisomal membrane proteins...
  5. Matsuzono Y, Fujiki Y. In vitro transport of membrane proteins to peroxisomes by shuttling receptor Pex19p. J Biol Chem. 2006;281:36-42 pubmed
    ..Together, these results strongly suggested that Pex19p translocates the membrane peroxins from the cytosol to peroxisomes in an ATP- and Pex3p-dependent manner and then shuttles back to the cytosol. ..
  6. Halbach A, Lorenzen S, Landgraf C, Volkmer Engert R, Erdmann R, Rottensteiner H. Function of the PEX19-binding site of human adrenoleukodystrophy protein as targeting motif in man and yeast. PMP targeting is evolutionarily conserved. J Biol Chem. 2005;280:21176-82 pubmed
    We predicted in human peroxisomal membrane proteins (PMPs) the binding sites for PEX19, a key player in the topogenesis of PMPs, by virtue of an algorithm developed for yeast PMPs...
  7. Shibata H, Kashiwayama Y, Imanaka T, Kato H. Domain architecture and activity of human Pex19p, a chaperone-like protein for intracellular trafficking of peroxisomal membrane proteins. J Biol Chem. 2004;279:38486-94 pubmed
    ..This idea is supported by our detection of the Pex19p-Pex3p-PMP22 ternary complex...
  8. Fang Y, Morrell J, Jones J, Gould S. PEX3 functions as a PEX19 docking factor in the import of class I peroxisomal membrane proteins. J Cell Biol. 2004;164:863-75 pubmed
    b>PEX19 is a chaperone and import receptor for newly synthesized, class I peroxisomal membrane proteins (PMPs)...
  9. Pinto M, Grou C, Alencastre I, Oliveira M, Sa Miranda C, Fransen M, et al. The import competence of a peroxisomal membrane protein is determined by Pex19p before the docking step. J Biol Chem. 2006;281:34492-502 pubmed

More Information

Publications86

  1. Jones J, Morrell J, Gould S. PEX19 is a predominantly cytosolic chaperone and import receptor for class 1 peroxisomal membrane proteins. J Cell Biol. 2004;164:57-67 pubmed
    ..Here, we demonstrate that PEX19 binds and stabilizes newly synthesized PMPs in the cytosol, binds to multiple PMP targeting signals (mPTSs), ..
  2. Brosius U, Dehmel T, Gartner J. Two different targeting signals direct human peroxisomal membrane protein 22 to peroxisomes. J Biol Chem. 2002;277:774-84 pubmed
    ..Both of these peroxisomal targeting regions interact with PEX19, a factor required for peroxisome membrane synthesis...
  3. Jones J, Morrell J, Gould S. Multiple distinct targeting signals in integral peroxisomal membrane proteins. J Cell Biol. 2001;153:1141-50 pubmed
    ..These results challenge a major assumption of most PMP targeting studies. In addition, we demonstrate that PEX19, a factor required for peroxisomal membrane biogenesis, interacts with the two minimal targeting regions of PMP34...
  4. Schmidt F, Treiber N, Zocher G, Bjelic S, Steinmetz M, Kalbacher H, et al. Insights into peroxisome function from the structure of PEX3 in complex with a soluble fragment of PEX19. J Biol Chem. 2010;285:25410-7 pubmed publisher
    The human peroxins PEX3 and PEX19 play a central role in peroxisomal membrane biogenesis. The membrane-anchored PEX3 serves as the receptor for cytosolic PEX19, which in turn recognizes newly synthesized peroxisomal membrane proteins...
  5. Neufeld C, Filipp F, Simon B, Neuhaus A, Schüller N, David C, et al. Structural basis for competitive interactions of Pex14 with the import receptors Pex5 and Pex19. EMBO J. 2009;28:745-54 pubmed publisher
    ..Pex14 is a central component of the peroxisomal import machinery and binds the soluble receptors Pex5 and Pex19, which have important function in the assembly of peroxisome matrix and membrane, respectively...
  6. Schueller N, Holton S, Fodor K, Milewski M, Konarev P, Stanley W, et al. The peroxisomal receptor Pex19p forms a helical mPTS recognition domain. EMBO J. 2010;29:2491-500 pubmed publisher
  7. Matsuzono Y, Kinoshita N, Tamura S, Shimozawa N, Hamasaki M, Ghaedi K, et al. Human PEX19: cDNA cloning by functional complementation, mutation analysis in a patient with Zellweger syndrome, and potential role in peroxisomal membrane assembly. Proc Natl Acad Sci U S A. 1999;96:2116-21 pubmed
    ..We have isolated a human PEX19 cDNA (HsPEX19) by functional complementation of peroxisome deficiency of a mutant Chinese hamster ovary cell line, ..
  8. Matsuzono Y, Matsuzaki T, Fujiki Y. Functional domain mapping of peroxin Pex19p: interaction with Pex3p is essential for function and translocation. J Cell Sci. 2006;119:3539-50 pubmed
    ..the C-terminal 38 amino acid residues and the N-terminal 11 residues, maintained peroxisome-restoring activity in pex19 cells. The sequence 12-261 was essential for re-establishing peroxisome activity...
  9. Kammerer S, Arnold N, Gutensohn W, Mewes H, Kunau W, Höfler G, et al. Genomic organization and molecular characterization of a gene encoding HsPXF, a human peroxisomal farnesylated protein. Genomics. 1997;45:200-10 pubmed
    ..Recently we published data on the cDNA of the human gene HK33 (A. Braun et al...
  10. Gotte K, Girzalsky W, Linkert M, Baumgart E, Kammerer S, Kunau W, et al. Pex19p, a farnesylated protein essential for peroxisome biogenesis. Mol Cell Biol. 1998;18:616-28 pubmed
    ..The human HK33 gene product was identified as the putative human ortholog of Pex19p...
  11. Fransen M, Vastiau I, Brees C, Brys V, Mannaerts G, Van Veldhoven P. Analysis of human Pex19p's domain structure by pentapeptide scanning mutagenesis. J Mol Biol. 2005;346:1275-86 pubmed
    ..Here, we have employed transposon mutagenesis to generate a library of human pex19 alleles coding for Pex19p variants containing random in-frame pentapeptide insertions...
  12. Fransen M, Vastiau I, Brees C, Brys V, Mannaerts G, Van Veldhoven P. Potential role for Pex19p in assembly of PTS-receptor docking complexes. J Biol Chem. 2004;279:12615-24 pubmed
    ..Importantly, we also found that amino acid substitutions resulting in a strongly reduced binding affinity for Pex13p affect the peroxisomal localization of Pex14p. ..
  13. Fransen M, Wylin T, Brees C, Mannaerts G, Van Veldhoven P. Human pex19p binds peroxisomal integral membrane proteins at regions distinct from their sorting sequences. Mol Cell Biol. 2001;21:4413-24 pubmed
  14. Fujiki Y, Matsuzono Y, Matsuzaki T, Fransen M. Import of peroxisomal membrane proteins: the interplay of Pex3p- and Pex19p-mediated interactions. Biochim Biophys Acta. 2006;1763:1639-46 pubmed
    ..Here we review the recent progress made in our understanding of the role of two key players in PMP biogenesis, Pex3p and Pex19p. ..
  15. Muntau A, Roscher A, Kunau W, Dodt G. The interaction between human PEX3 and PEX19 characterized by fluorescence resonance energy transfer (FRET) analysis. Eur J Cell Biol. 2003;82:333-42 pubmed
    ..Among the corresponding peroxins the interaction between PEX3 and PEX19 is essential for early peroxisome biogenesis...
  16. Gloeckner C, Mayerhofer P, Landgraf P, Muntau A, Holzinger A, Gerber J, et al. Human adrenoleukodystrophy protein and related peroxisomal ABC transporters interact with the peroxisomal assembly protein PEX19p. Biochem Biophys Res Commun. 2000;271:144-50 pubmed
  17. Delille H, Schrader M. Targeting of hFis1 to peroxisomes is mediated by Pex19p. J Biol Chem. 2008;283:31107-15 pubmed publisher
    ..Our findings indicate that targeting of hFis1 to peroxisomes and mitochondria are independent events and support a direct, Pex19p-dependent targeting of peroxisomal tail-anchored proteins. ..
  18. Sato Y, Shibata H, Nakatsu T, Nakano H, Kashiwayama Y, Imanaka T, et al. Structural basis for docking of peroxisomal membrane protein carrier Pex19p onto its receptor Pex3p. EMBO J. 2010;29:4083-93 pubmed publisher
    ..The Pex19p peptide contains a characteristic motif, consisting of the leucine triad (Leu18, Leu21, Leu22), and Phe29, which are critical for the Pex3p binding and peroxisome biogenesis. ..
  19. Biermanns M, Gartner J. Targeting elements in the amino-terminal part direct the human 70-kDa peroxisomal integral membrane protein (PMP70) to peroxisomes. Biochem Biophys Res Commun. 2001;285:649-55 pubmed
    ..Furthermore, peroxin 19 (PEX19) interactions are not required for targeting human PMP70 to peroxisomes...
  20. Miglior S, Bertuzzi F. Exfoliative glaucoma: new evidence in the pathogenesis and treatment. Prog Brain Res. 2015;221:233-41 pubmed publisher
    Exfoliation or pseudoexfoliation syndrome (PXF) is an age-related ocular and systemic disease in which abnormal extracellular material is produced and accumulates in many tissues...
  21. Jiang H, Yang L, Xing X, Yan M, Guo X, Yang B, et al. HPLC-PDA Combined with Chemometrics for Quantitation of Active Components and Quality Assessment of Raw and Processed Fruits of Xanthium strumarium L. Molecules. 2018;23: pubmed publisher
    ..was proposed for evaluating the active components in 30 batches of raw and processed Xanthii Fructus (RXF and PXF) samples, based on high-performance liquid chromatography coupled with photodiode array detection (HPLC-PDA)...
  22. Vasilevsky S, Stojanov M, Greub G, Baud D. Chlamydial polymorphic membrane proteins: regulation, function and potential vaccine candidates. Virulence. 2016;7:11-22 pubmed publisher
    ..In C. trachomatis, PmpB, PmpC, PmpD and PmpI were the proteins eliciting the strongest immune response among adolescents with and without pelvic inflammatory ..
  23. Giannopoulou E, Emmanouilidis L, Sattler M, Dodt G, Wilmanns M. Towards the molecular mechanism of the integration of peroxisomal membrane proteins. Biochim Biophys Acta. 2016;1863:863-9 pubmed publisher
    ..Nevertheless, it is generally accepted that peroxisomes employ three proteins - Pex3, Pex19 and Pex16 in mammals - for the insertion of peroxisomal membrane proteins into the peroxisomal membrane...
  24. Lossouarn J, Nesbø C, Mercier C, Zhaxybayeva O, Johnson M, Charchuck R, et al. 'Ménage à trois': a selfish genetic element uses a virus to propagate within Thermotogales. Environ Microbiol. 2015;17:3278-88 pubmed publisher
    ..3 kb (pMP1) also carried by M. piezophila...
  25. Govetto A, Lorente R, Vázquez de Parga P, Rojas L, Moreno C, Lagoa F, et al. Frequency of pseudoexfoliation among patients scheduled for cataract surgery. J Cataract Refract Surg. 2015;41:1224-31 pubmed publisher
    To assess the frequency of pseudoexfoliation syndrome (PXF) in patients scheduled for cataract surgery and to evaluate its association with pupil dilation, lens nucleus hardness, intraocular pressure (IOP), glaucoma, age, and sex...
  26. Huang W, Xue D, Chen J, Zhou J, Wu D, Xing N. [Effects on vascular permeability with different fluid resuscitation regimens during burn stage in swines]. Zhonghua Yi Xue Za Zhi. 2015;95:943-6 pubmed
    ..Then lung tissue samples were obtained and pulmonary vascular permeability index (PMPI) was measured. Statistical analyses were performed. All swines survived shock stage...
  27. Samra N, Arava Y. Novel RNA-Binding Proteins Isolation by the RaPID Methodology. J Vis Exp. 2016;: pubmed publisher
    ..We recently used this protocol to identify novel proteins associated with the ER-associated PMP1 mRNA. Here, we provide a detailed protocol of RaPID, and discuss some of its limitations and advantages.
  28. Lee M, Sumpter R, Zou Z, Sirasanagandla S, Wei Y, Mishra P, et al. Peroxisomal protein PEX13 functions in selective autophagy. EMBO Rep. 2017;18:48-60 pubmed publisher
    ..function of PEX13 is shared with another peroxin family member PEX3, but not with two other peroxins, PEX14 and PEX19, which are required for general autophagy...
  29. Satoh R, Matsumura Y, Tanaka A, Takada M, Ito Y, Hagihara K, et al. Spatial regulation of the KH domain RNA-binding protein Rnc1 mediated by a Crm1-independent nuclear export system in Schizosaccharomyces pombe. Mol Microbiol. 2017;104:428-448 pubmed publisher
    ..Fission yeast rnc1+ encodes a K Homology (KH)-type RBP, which binds and stabilizes the Pmp1 MAPK phosphatase mRNA thereby suppressing the Cl- hypersensitivity of calcineurin deletion and MAPK ..
  30. Mohamed S, El Meleagy E, Nasr A, Ebberink M, Wanders R, Waterham H. A mutation in PEX19 causes a severe clinical phenotype in a patient with peroxisomal biogenesis disorder. Am J Med Genet A. 2010;152A:2318-21 pubmed publisher
    ..Immunofluoresence microscopy revealed the absence of peroxisomes in fibroblasts. The patient was assigned to the PEX19 complementation group. Subsequent mutation analysis of the PEX19 gene revealed homozygosity for a c...
  31. Gartner J, Jimenez Sanchez G, Roerig P, Valle D. Genomic organization of the 70-kDa peroxisomal membrane protein gene (PXMP1). Genomics. 1998;48:203-8 pubmed
    ..We report the cloning and characterization of the human PMP70 structural gene (gene symbol: PXMP1) localized on human chromosome 1p21-p22...
  32. Emmanouilidis L, Schütz U, Tripsianes K, Madl T, Radke J, Rucktäschel R, et al. Allosteric modulation of peroxisomal membrane protein recognition by farnesylation of the peroxisomal import receptor PEX19. Nat Commun. 2017;8:14635 pubmed publisher
    The transport of peroxisomal membrane proteins (PMPs) requires the soluble PEX19 protein as chaperone and import receptor. Recognition of cargo PMPs by the C-terminal domain (CTD) of PEX19 is required for peroxisome biogenesis in vivo...
  33. Mayerhofer P, Kattenfeld T, Roscher A, Muntau A. Two splice variants of human PEX19 exhibit distinct functions in peroxisomal assembly. Biochem Biophys Res Commun. 2002;291:1180-6 pubmed
    b>PEX19 has been shown to play a central role in the early steps of peroxisomal membrane synthesis...
  34. Vazquez Ferreiro P, Carrera Hueso F, Poquet Jornet J, Fikri Benbrahim N, Diaz Rey M, Sanjuan Cerveró R. Intraoperative complications of phacoemulsification in pseudoexfoliation: Metaanalysis. J Cataract Refract Surg. 2016;42:1666-1675 pubmed publisher
    This review analyzed the effect of pseudoexfoliation (PXF) syndrome on the risk for surgical complications during phacoemulsification...
  35. Kinoshita N, Matsuura A, Fujiki Y. Peroxisome biogenesis: a novel inducible PEX19 splicing variant is involved in early stages of peroxisome proliferation. J Biochem. 2017;161:297-308 pubmed publisher
    ..By functional phenotype-complementation assay using a pex19 Chinese hamster ovary cell mutant ZP119, we herein cloned a rat cDNA encoding a protein similar to Pex19p, but ..
  36. Hasan M, Yaguchi T, Sugihara T, Kumar P, Taira K, Reddel R, et al. CARF is a novel protein that cooperates with mouse p19ARF (human p14ARF) in activating p53. J Biol Chem. 2002;277:37765-70 pubmed
    ..It co-localizes and interacts with ARF in the nucleolus. We demonstrate that CARF is co-regulated with ARF, cooperates with it in activating p53, and thus acts as a novel component of the ARF-p53-p21 pathway. ..
  37. Esmaeili M, Ghaedi K, Shoaraye Nejati A, Nematollahi M, Shiralyian H, Nasr Esfahani M. Pioglitazone significantly prevented decreased rate of neural differentiation of mouse embryonic stem cells which was reduced by Pex11β knock-down. Neuroscience. 2016;312:35-47 pubmed publisher
    ..Additionally, mRNA levels of other peroxisome-related genes such as PMP70, Pex11α, Catalase, Pex19 and Pex5 were also significantly reduced by Pex11β knock-down (p<0.05)...
  38. Armarnik S, Mimouni M, Rosen E, Assia E, Segev F. Modified corneal incisions in intraoperative floppy iris syndrome (IFIS)-prone patients. Graefes Arch Clin Exp Ophthalmol. 2016;254:123-7 pubmed publisher
    ..We recorded preoperative gender, age, α-antagonist medication, coexisting pseudoexfoliation (PXF), and intraoperative use of ophthalmic viscosurgical devices (OVDs), pupil size, complications, IFIS grading and ..
  39. Agrawal G, Subramani S. De novo peroxisome biogenesis: Evolving concepts and conundrums. Biochim Biophys Acta. 2016;1863:892-901 pubmed publisher
    ..In addition, plausible roles of the three key peroxins Pex3, Pex16 and Pex19, which are also central to the growth and division pathway, have been suggested in the de novo process...
  40. Ren J, Lian T, Shao L, Liu Y, Liu Q. PmpI antibody reduce the inhibitory effect of Vp1 on Chlamydia trachomatis Infectivity. Can J Microbiol. 2018;: pubmed publisher
    ..We found that purified Vp1 can bind to the C. trachomatis outer membrane protein PmpI utilizing a Far-Western blot and GST pull-down assay...
  41. Legrand E, Forget Leray J, Duflot A, Olivier S, Thome J, Danger J, et al. Transcriptome analysis of the copepod Eurytemora affinis upon exposure to endocrine disruptor pesticides: Focus on reproduction and development. Aquat Toxicol. 2016;176:64-75 pubmed publisher
    ..Copepods were exposed to sublethal concentrations of pyriproxyfen (PXF) and chlordecone (CLD) separately...
  42. Gayathri R, Coral K, Sharmila F, Sripriya S, Sripriya K, Manish P, et al. Correlation of Aqueous Humor Lysyl Oxidase Activity with TGF-ß Levels and LOXL1 Genotype in Pseudoexfoliation. Curr Eye Res. 2016;41:1331-1338 pubmed
    Pseudoexfoliation (PXF) is a microfibrillopathy involving disordered elastogenesis. Abnormal extracellular matrix (ECM) production underlies the pathophysiology of PXF...
  43. Legrand E, Boulangé Lecomte C, Restoux G, Tremolet G, Duflot A, Forget Leray J. Individual and mixture acute toxicity of model pesticides chlordecone and pyriproxyfen in the estuarine copepod Eurytemora affinis. Environ Sci Pollut Res Int. 2017;24:5976-5984 pubmed publisher
    ..In this study, we investigated the acute toxicity of two model insecticides, chlordecone (CLD) and pyriproxyfen (PXF), alone and in mixtures, in the estuarine copepod Eurytemora affinis...
  44. Schrul B, Kopito R. Peroxin-dependent targeting of a lipid-droplet-destined membrane protein to ER subdomains. Nat Cell Biol. 2016;18:740-51 pubmed publisher
    ..synthesized UBXD8 is post-translationally inserted into discrete ER subdomains by a mechanism requiring cytosolic PEX19 and membrane-integrated PEX3, proteins hitherto exclusively implicated in peroxisome biogenesis...
  45. Uyama T, Tsuboi K, Ueda N. An involvement of phospholipase A/acyltransferase family proteins in peroxisome regulation and plasmalogen metabolism. FEBS Lett. 2017;591:2745-2760 pubmed publisher
    ..This finding might be related to the inhibitory effect of PLAAT-3 on the chaperone activity of the peroxin PEX19. In this article, we will review our recent findings about PLAAT proteins, with special reference to their roles ..
  46. Şimşek C, Oto S, Yilmaz G, Altinors D, Akman A, Güngör S. Comparison of the mechanical properties of the anterior lens capsule in senile cataract, senile cataract with trypan blue application, and pseudoexfoliation syndrome. J Cataract Refract Surg. 2017;43:1054-1061 pubmed publisher
    ..Group 1 comprised patients with senile cataract, Group 2 patients had pseudoexfoliation (PXF) syndrome, and Group 3 patients had dye-enhanced cataract surgery...
  47. Farré J, Carolino K, Stasyk O, Stasyk O, Hodzic Z, Agrawal G, et al. A New Yeast Peroxin, Pex36, a Functional Homolog of Mammalian PEX16, Functions in the ER-to-Peroxisome Traffic of Peroxisomal Membrane Proteins. J Mol Biol. 2017;429:3743-3762 pubmed publisher
    ..In mammals and yeast, several PMPs traffic via the ER in a Pex3- and Pex19-dependent manner...
  48. Lombard Platet G, Savary S, Sarde C, Mandel J, Chimini G. A close relative of the adrenoleukodystrophy (ALD) gene codes for a peroxisomal protein with a specific expression pattern. Proc Natl Acad Sci U S A. 1996;93:1265-9 pubmed
    ..for being implicated in one of the complementation groups of Zellweger syndrome, a genetically heterogeneous disorder of peroxisome biogenesis, rare cases of which were found to be associated with mutations in the PMP70 (PXMP1) gene.
  49. Yagita Y, Hiromasa T, Fujiki Y. Tail-anchored PEX26 targets peroxisomes via a PEX19-dependent and TRC40-independent class I pathway. J Cell Biol. 2013;200:651-66 pubmed publisher
    ..Although the targeting of TA proteins to peroxisomes is dependent on PEX19, the mechanistic details of PEX19-dependent targeting and the signal that directs TA proteins to peroxisomes have ..
  50. Schmidt F, Dietrich D, Eylenstein R, Groemping Y, Stehle T, Dodt G. The role of conserved PEX3 regions in PEX19-binding and peroxisome biogenesis. Traffic. 2012;13:1244-60 pubmed publisher
    The human peroxins PEX3 and PEX19 are essential for peroxisome biogenesis. They mediate the import of membrane proteins as well as the de novo formation of peroxisomes...
  51. Liu Y, McNamara R. Elevated Delta-6 desaturase (FADS2) gene expression in the prefrontal cortex of patients with bipolar disorder. J Psychiatr Res. 2011;45:269-72 pubmed publisher
    ..In the present study we determined FADS1 (?5 desaturase), FADS2 (?6 desaturase), HELO1 [ELOVL5] (elongase), PEX19 (peroxisome), and SCD (stearoyl-CoA desaturase [?9 desaturase]) mRNA expression in the postmortem prefrontal ..
  52. Couteau C, Coiffard L. [In vitro comparison of the efficacy and photostability of three sunscreen creams]. Ann Dermatol Venereol. 2010;137:95-9 pubmed publisher
    ..It is somewhat difficult to understand the coexistence on the market of products having different types of status without any prior establishment of clear limits in terms of indices, for example. ..
  53. Ito M, Iidawa S, Izuka M, Haito S, Segawa H, Kuwahata M, et al. Interaction of a farnesylated protein with renal type IIa Na/Pi co-transporter in response to parathyroid hormone and dietary phosphate. Biochem J. 2004;377:607-16 pubmed
    ..a strong interaction of the Na/P(i) IIa co-transporter with a small protein known as the PEX19 (human peroxisomal farnesylated protein; PxF, Pex19p)...
  54. Huang T, Zheng D, Houmard J, Brault J, Hickner R, Cortright R. Overexpression of PGC-1α increases peroxisomal activity and mitochondrial fatty acid oxidation in human primary myotubes. Am J Physiol Endocrinol Metab. 2017;312:E253-E263 pubmed publisher
    ..After overexpression of PGC-1α, 1) peroxisomal membrane protein 70 kDa (PMP70), PEX19, and mitochondrial citrate synthetase protein content were significantly elevated (P < 0...
  55. Rao A, Das G, Sarangi S, Padhy D. Conjunctival changes in different clinical variants of early pseudoexfoliation. Int Ophthalmol. 2017;: pubmed publisher
    To evaluate the conjunctival signs in different forms of pseudoexfoliation (PXF) syndrome to identify signs predicting early forms of the disease.
  56. Kashiwayama Y, Asahina K, Shibata H, Morita M, Muntau A, Roscher A, et al. Role of Pex19p in the targeting of PMP70 to peroxisome. Biochim Biophys Acta. 2005;1746:116-28 pubmed
    ..These results suggest that Pex19p binds to PMP70 co-translationally and keeps PMP70 as a proper conformation for the localization to peroxisome...
  57. Hattula K, Hirschberg D, Kalkkinen N, Butcher S, Ora A. Association between the intrinsically disordered protein PEX19 and PEX3. PLoS ONE. 2014;9:e103101 pubmed publisher
    ..For further insight into the interaction of PEX3 and PEX19, we used hydrogen exchange mass spectrometry to monitor conformational changes during complex formation between ..
  58. Yernaux C, Fransen M, Brees C, Lorenzen S, Michels P. Trypanosoma brucei glycosomal ABC transporters: identification and membrane targeting. Mol Membr Biol. 2006;23:157-72 pubmed
    ..We also identified the T. brucei homologue of peroxin PEX19, which is considered to act as a chaperonin and/or receptor for cytosolically synthesized proteins destined for ..
  59. Vastiau I, Anthonio E, Brams M, Brees C, Young S, Van de Velde S, et al. Farnesylation of Pex19p is not essential for peroxisome biogenesis in yeast and mammalian cells. Cell Mol Life Sci. 2006;63:1686-99 pubmed
    ..Summarized, these observations indicate that the CAAX box-mediated processing steps of Pex19p are dispensable for peroxisome biogenesis in yeast and mammalian cells. ..
  60. Liu Y, Jandacek R, Rider T, Tso P, McNamara R. Elevated delta-6 desaturase (FADS2) expression in the postmortem prefrontal cortex of schizophrenic patients: relationship with fatty acid composition. Schizophr Res. 2009;109:113-20 pubmed publisher
    ..Here we determined Delta5 desaturase (FADS1), Delta6 desaturase (FADS2), elongase (HELO1 [ELOVL5]), peroxisomal (PEX19), and Delta9 desaturase (stearoyl-CoA desaturase, SCD) mRNA expression, and relevant fatty acid product:precursor ..
  61. Sugihara T, Kaul S, Kato J, Reddel R, Nomura H, Wadhwa R. Pex19p dampens the p19ARF-p53-p21WAF1 tumor suppressor pathway. J Biol Chem. 2001;276:18649-52 pubmed
    We isolated a 33-kDa protein, Pex19p/HK33/HsPXF, as a p19ARF-binding protein in a yeast two-hybrid screen...
  62. Nyathi Y, Zhang X, Baldwin J, Bernhardt K, Johnson B, Baldwin S, et al. Pseudo half-molecules of the ABC transporter, COMATOSE, bind Pex19 and target to peroxisomes independently but are both required for activity. FEBS Lett. 2012;586:2280-6 pubmed publisher
    ..The N- and C-terminal pseudo-halves of COMATOSE (CTS; AtABCD1) were expressed as separate polypeptides which bound Pex19 in vitro and targeted independently to the peroxisome membrane in yeast, where they were stable but not functional...
  63. Holzinger A, Roscher A, Landgraf P, Lichtner P, Kammerer S. Genomic organization and chromosomal localization of the human peroxisomal membrane protein-1-like protein (PXMP1-L) gene encoding a peroxisomal ABC transporter. FEBS Lett. 1998;426:238-42 pubmed
    The cDNA of the peroxisomal membrane protein-1-like protein (PXMP1-L, synonyms: PMP69, P70R), a novel peroxisomal ATP binding cassette transporter of yet unknown function, has recently been cloned...
  64. Yamashita S, Abe K, Tatemichi Y, Fujiki Y. The membrane peroxin PEX3 induces peroxisome-ubiquitination-linked pexophagy. Autophagy. 2014;10:1549-64 pubmed publisher
  65. Tompkins V, Hagen J, Zediak V, Quelle D. Identification of novel ARF binding proteins by two-hybrid screening. Cell Cycle. 2006;5:641-6 pubmed
    ..The potential physiological roles of these novel ARF binding proteins in regulating ARF signaling are discussed. ..
  66. Satoh R, Hagihara K, Sugiura R. Rae1-mediated nuclear export of Rnc1 is an important determinant in controlling MAPK signaling. Curr Genet. 2018;64:103-108 pubmed publisher
    ..Rnc1 negatively regulates MAPK signaling activation via mRNA stabilization of the dual-specificity MAPK phosphatase Pmp1, which dephosphorylates MAPK Pmk1...
  67. Soukupova M, Sprenger C, Gorgas K, Kunau W, Dodt G. Identification and characterization of the human peroxin PEX3. Eur J Cell Biol. 1999;78:357-74 pubmed
    ..The farnesylated peroxisomal membrane protein PEX19 interacts with HsPEX3 in a mammalian two-hybrid assay in human fibroblasts...
  68. Ragam A, Ritterband D, Waisbren E, Mathew Padiyedathu J, Kang J, Seedor J. Clinical Outcomes and Intraocular Pressure Control after Scleral-glued Intraocular Lens Insertion in Eyes with Pseudoexfoliation. J Glaucoma. 2017;: pubmed publisher
    To analyze clinical outcomes and intraocular pressure (IOP) control following scleral-glued intraocular lens (IOL) fixation in eyes with pseudoexfoliation (PXF).
  69. Braun A, Kammerer S, Weissenhorn W, Weiss E, Cleve H. Sequence of a putative human housekeeping gene (HK33) localized on chromosome 1. Gene. 1994;146:291-5 pubmed
    A gene (HK33) localized on human chromosome 1 has been detected by crossreaction of its fusion protein with a monospecific antiserum directed against human vitamin-D-binding protein (hDBP; group-specific component)...
  70. Fransen M, Brees C, Ghys K, Amery L, Mannaerts G, Ladant D, et al. Analysis of mammalian peroxin interactions using a non-transcription-based bacterial two-hybrid assay. Mol Cell Proteomics. 2002;1:243-52 pubmed
  71. Wadhwa R, Sugihara T, Hasan M, Duncan E, Taira K, Kaul S. A novel putative collaborator of p19ARF. Exp Gerontol. 2003;38:245-52 pubmed
    ..CARF is a novel binding partner of ARF and might be involved in its p53-dependent or -independent tumor suppressive functions. ..
  72. Muntau A, Roscher A, Kunau W, Dodt G. Interaction of PEX3 and PEX19 visualized by fluorescence resonance energy transfer (FRET). Adv Exp Med Biol. 2003;544:221-4 pubmed
  73. Dunster K, Lai F, Sentry J. Limkain b1, a novel human autoantigen localized to a subset of ABCD3 and PXF marked peroxisomes. Clin Exp Immunol. 2005;140:556-63 pubmed
    ..novel autoantigen that co-localizes with a subset of cytoplasmic microbodies marked by ABCD3 (PMP-70) and/or PXF (PEX19)...
  74. Pinto M, Grou C, Fransen M, Sa Miranda C, Azevedo J. The cytosolic domain of PEX3, a protein involved in the biogenesis of peroxisomes, binds membrane lipids. Biochim Biophys Acta. 2009;1793:1669-75 pubmed publisher
    ..peroxisomal intrinsic membrane proteins are recognized in the cytosol and targeted to the peroxisomal membrane by PEX19. At the organelle membrane the PEX19-cargo protein complex interacts with PEX3, a protein believed to possess only ..
  75. Murakami K, Ichinohe Y, Koike M, Sasaoka N, Iemura S, Natsume T, et al. VCP Is an integral component of a novel feedback mechanism that controls intracellular localization of catalase and H2O2 Levels. PLoS ONE. 2013;8:e56012 pubmed publisher
    ..g. cell cycle and protein degradation, etc. Here we show that VCP and PEX19, a protein essential for peroxisome biogenesis, interact with each other...
  76. Uyama T, Kawai K, Kono N, Watanabe M, Tsuboi K, Inoue T, et al. Interaction of Phospholipase A/Acyltransferase-3 with Pex19p: A POSSIBLE INVOLVEMENT IN THE DOWN-REGULATION OF PEROXISOMES. J Biol Chem. 2015;290:17520-34 pubmed publisher
    ..Moreover, PLA/AT-3 inhibited the binding of Pex19 to peroxisomal membrane proteins, such as Pex3p and Pex11βp...