ND2

Summary

Gene Symbol: ND2
Description: MTND2
Alias: MTND2, MTND2, NADH dehydrogenase subunit 2
Species: human
Products:     ND2

Top Publications

  1. Anderson S, Bankier A, Barrell B, de Bruijn M, Coulson A, Drouin J, et al. Sequence and organization of the human mitochondrial genome. Nature. 1981;290:457-65 pubmed
    ....
  2. Canter J, Haas D, Kallianpur A, Ritchie M, Robbins G, Shafer R, et al. The mitochondrial pharmacogenomics of haplogroup T: MTND2*LHON4917G and antiretroviral therapy-associated peripheral neuropathy. Pharmacogenomics J. 2008;8:71-7 pubmed
    ..Two non-synonymous mitochondrial DNA polymorphisms, MTND1*LHON4216C (4216C) and MTND2*LHON4917G (4917G) were characterized in HIV-infected participants exposed to NRTIs in a randomized clinical trial...
  3. Kokaze A, Ishikawa M, Matsunaga N, Karita K, Yoshida M, Ohtsu T, et al. NADH dehydrogenase subunit-2 237 Leu/Met polymorphism modulates the effects of coffee consumption on the risk of hypertension in middle-aged Japanese men. J Epidemiol. 2009;19:231-6 pubmed
    ..The NADH dehydrogenase subunit-2 237 leucine/methionine (ND2-237 Leu/Met) polymorphism is associated with longevity and modifies the effects of alcohol consumption on blood ..
  4. Ochoa A, Onorato D, Fitak R, Roelke Parker M, Culver M. Evolutionary and Functional Mitogenomics Associated With the Genetic Restoration of the Florida Panther. J Hered. 2017;108:449-455 pubmed publisher
    ..We directly and indirectly assessed the presence of potential deleterious SNPs in the ND2 and ND5 genes in Florida panthers prior to and as a consequence of the introduction of Texas pumas...
  5. Webb E, Broderick P, Chandler I, Lubbe S, Penegar S, Tomlinson I, et al. Comprehensive analysis of common mitochondrial DNA variants and colorectal cancer risk. Br J Cancer. 2008;99:2088-93 pubmed publisher
    ..In conclusion, our results provide little evidence that mitochondrial genetic background plays a role in modifying an individual's risk of developing CRC. ..
  6. Hao Y, Zou Y, Ding Y, Xu W, Yan Z, Li X, et al. Complete mitochondrial genomes of Anopheles stephensi and An. dirus and comparative evolutionary mitochondriomics of 50 mosquitoes. Sci Rep. 2017;7:7666 pubmed publisher
    ..PCGs show signals of purifying selection, but evidence for positive selection in ND2, ND4 and ND6 is found...
  7. Ugalde C, Hinttala R, Timal S, Smeets R, Rodenburg R, Uusimaa J, et al. Mutated ND2 impairs mitochondrial complex I assembly and leads to Leigh syndrome. Mol Genet Metab. 2007;90:10-4 pubmed
    We describe a novel mitochondrial ND2 mutation (T4681C) in a patient presenting with Leigh Syndrome. Biochemical analyses revealed a low isolated complex I activity in patient's fibroblasts, blood and skeletal muscle...
  8. Lunnon K, Keohane A, Pidsley R, Newhouse S, Riddoch Contreras J, Thubron E, et al. Mitochondrial genes are altered in blood early in Alzheimer's disease. Neurobiol Aging. 2017;53:36-47 pubmed publisher
    ..closest to the transcription start site of the polycistronic heavy chain mitochondrial transcript (MT-ND1, MT-ND2, MT-ATP6, MT-CO1, MT-CO2, MT-C03) and MT-ND6 transcribed from the light chain...
  9. Escalona T, Weadick C, Antunes A. Adaptive Patterns of Mitogenome Evolution Are Associated with the Loss of Shell Scutes in Turtles. Mol Biol Evol. 2017;34:2522-2536 pubmed publisher
    ..Positively selected sites were found to be particularly prevalent in OXPHOS Complex I proteins, especially subunit ND2, along both positively selected lineages, consistent with convergent adaptive evolution...
  10. Liao W, Pang Y, Yu C, Wen J, Zhang Y, Li X. Novel mutations of mitochondrial DNA associated with type 2 diabetes in Chinese Han population. Tohoku J Exp Med. 2008;215:377-84 pubmed
    ..0006, OR 0.06 [95% CI 0.008-0.476]). MtSNPs T3394C in NADH dehydrogenase subunit 1 (ND1), G4491A in ND2, T16189C and T16519C were found with significantly higher frequency in patients with T2DM than in the controls (..

Detail Information

Publications62

  1. Anderson S, Bankier A, Barrell B, de Bruijn M, Coulson A, Drouin J, et al. Sequence and organization of the human mitochondrial genome. Nature. 1981;290:457-65 pubmed
    ....
  2. Canter J, Haas D, Kallianpur A, Ritchie M, Robbins G, Shafer R, et al. The mitochondrial pharmacogenomics of haplogroup T: MTND2*LHON4917G and antiretroviral therapy-associated peripheral neuropathy. Pharmacogenomics J. 2008;8:71-7 pubmed
    ..Two non-synonymous mitochondrial DNA polymorphisms, MTND1*LHON4216C (4216C) and MTND2*LHON4917G (4917G) were characterized in HIV-infected participants exposed to NRTIs in a randomized clinical trial...
  3. Kokaze A, Ishikawa M, Matsunaga N, Karita K, Yoshida M, Ohtsu T, et al. NADH dehydrogenase subunit-2 237 Leu/Met polymorphism modulates the effects of coffee consumption on the risk of hypertension in middle-aged Japanese men. J Epidemiol. 2009;19:231-6 pubmed
    ..The NADH dehydrogenase subunit-2 237 leucine/methionine (ND2-237 Leu/Met) polymorphism is associated with longevity and modifies the effects of alcohol consumption on blood ..
  4. Ochoa A, Onorato D, Fitak R, Roelke Parker M, Culver M. Evolutionary and Functional Mitogenomics Associated With the Genetic Restoration of the Florida Panther. J Hered. 2017;108:449-455 pubmed publisher
    ..We directly and indirectly assessed the presence of potential deleterious SNPs in the ND2 and ND5 genes in Florida panthers prior to and as a consequence of the introduction of Texas pumas...
  5. Webb E, Broderick P, Chandler I, Lubbe S, Penegar S, Tomlinson I, et al. Comprehensive analysis of common mitochondrial DNA variants and colorectal cancer risk. Br J Cancer. 2008;99:2088-93 pubmed publisher
    ..In conclusion, our results provide little evidence that mitochondrial genetic background plays a role in modifying an individual's risk of developing CRC. ..
  6. Hao Y, Zou Y, Ding Y, Xu W, Yan Z, Li X, et al. Complete mitochondrial genomes of Anopheles stephensi and An. dirus and comparative evolutionary mitochondriomics of 50 mosquitoes. Sci Rep. 2017;7:7666 pubmed publisher
    ..PCGs show signals of purifying selection, but evidence for positive selection in ND2, ND4 and ND6 is found...
  7. Ugalde C, Hinttala R, Timal S, Smeets R, Rodenburg R, Uusimaa J, et al. Mutated ND2 impairs mitochondrial complex I assembly and leads to Leigh syndrome. Mol Genet Metab. 2007;90:10-4 pubmed
    We describe a novel mitochondrial ND2 mutation (T4681C) in a patient presenting with Leigh Syndrome. Biochemical analyses revealed a low isolated complex I activity in patient's fibroblasts, blood and skeletal muscle...
  8. Lunnon K, Keohane A, Pidsley R, Newhouse S, Riddoch Contreras J, Thubron E, et al. Mitochondrial genes are altered in blood early in Alzheimer's disease. Neurobiol Aging. 2017;53:36-47 pubmed publisher
    ..closest to the transcription start site of the polycistronic heavy chain mitochondrial transcript (MT-ND1, MT-ND2, MT-ATP6, MT-CO1, MT-CO2, MT-C03) and MT-ND6 transcribed from the light chain...
  9. Escalona T, Weadick C, Antunes A. Adaptive Patterns of Mitogenome Evolution Are Associated with the Loss of Shell Scutes in Turtles. Mol Biol Evol. 2017;34:2522-2536 pubmed publisher
    ..Positively selected sites were found to be particularly prevalent in OXPHOS Complex I proteins, especially subunit ND2, along both positively selected lineages, consistent with convergent adaptive evolution...
  10. Liao W, Pang Y, Yu C, Wen J, Zhang Y, Li X. Novel mutations of mitochondrial DNA associated with type 2 diabetes in Chinese Han population. Tohoku J Exp Med. 2008;215:377-84 pubmed
    ..0006, OR 0.06 [95% CI 0.008-0.476]). MtSNPs T3394C in NADH dehydrogenase subunit 1 (ND1), G4491A in ND2, T16189C and T16519C were found with significantly higher frequency in patients with T2DM than in the controls (..
  11. Krzeminska U, Morales H, Greening C, Nyári A, Wilson R, Song B, et al. Population mitogenomics provides insights into evolutionary history, source of invasions acnd diversifying selection in the House Crow (Corvus splendens). Heredity (Edinb). 2017;: pubmed publisher
    ..of selection and assessments of changes in amino acid properties provide evidence of positive selection on the ND2 and ND5 genes against a background of purifying selection across the mitogenome...
  12. Woo H, Nguyen A, Jang K, Choi E, Ryu S, Hwang U. The complete mitochondrial genome of the Korean endemic millipede <i>Anaulaciulus</i> <i>koreanus</i> (Verhoeff, 1937), with notes on the gene arrangement of millipede orders. Zootaxa. 2017;4329:574-583 pubmed publisher
    ..The absence of tRNACys between the ND2 and COI regions is unique to the order Polydesmida, whereas the translocation of tRNATyr to between ND2 and COI is ..
  13. Washizuka S, Ikeda A, Kato N, Kato T. Possible relationship between mitochondrial DNA polymorphisms and lithium response in bipolar disorder. Int J Neuropsychopharmacol. 2003;6:421-4 pubmed
    ..05). Our findings suggest that the mtDNA 10398 polymorphism might be related to maintenance lithium treatment response. ..
  14. Gingrich J, Pelkey K, Fam S, Huang Y, Petralia R, Wenthold R, et al. Unique domain anchoring of Src to synaptic NMDA receptors via the mitochondrial protein NADH dehydrogenase subunit 2. Proc Natl Acad Sci U S A. 2004;101:6237-42 pubmed
    ..Here, we show that the unique domain of Src is a protein-protein interaction region and we identify NADH dehydrogenase subunit 2 (ND2) as a Src unique domain-interacting protein...
  15. Drovetski S, Reeves A, Red kin Y, Fadeev I, Koblik E, Sotnikov V, et al. Multi-locus reassessment of a striking discord between mtDNA gene trees and taxonomy across two congeneric species complexes. Mol Phylogenet Evol. 2017;: pubmed publisher
    ..To test mtDNA gene tree topology, we sequenced the mtDNA ND2 gene and 11 nuclear introns for seven wagtail species...
  16. Han G, Xia L, Li S, Jin Q, Song Y, Shen H, et al. The Association between the C5263T Mutation in the Mitochondrial ND2 Gene and Coronary Heart Disease among Young Chinese Han People. Biomed Environ Sci. 2017;30:280-287 pubmed publisher
    ..This study aimed to investigate the genetic background of mitochondrial genes in young patients with Coronary heart disease (CHD) to provide a foundation for the early prevention of young patients with CHD...
  17. Nash C, Kraczkowski M, Chernoff B. Insight into the population structure of hardhead silverside, Atherinomorus stipes (Teleostei: Atherinidae), in Belize and the Florida Keys using nd2. Ecol Evol. 2017;7:9503-9517 pubmed publisher
    ..For this study, the mitochondrial gene nd2 was amplified from 394 individuals collected from seven different Belizean Cays (N = 175) and eight ..
  18. Yamaguchi J, Hasegawa Y, Kawasaki M, Masui T, Kanoh T, Ishiguro N, et al. ALDH2 polymorphisms and bone mineral density in an elderly Japanese population. Osteoporos Int. 2006;17:908-13 pubmed
    ..31; 95% CI: 1.24-14.92; p=0.021). The present results suggest that active prophylactic interventions such as dietary, exercise, and pharmacological therapies should be offered to non-carriers of the Glu allele (Lys/Lys). ..
  19. Lal S, Madhavan M, Heng C. The association of mitochondrial DNA 5178 C > a polymorphism with plasma lipid levels among three ethnic groups. Ann Hum Genet. 2005;69:639-44 pubmed
    ..The C to A nucleotide transversion in the NADH dehydrogenase subunit 2 (MT-ND2) coding region of mitochondrial DNA has been reported to be associated with plasma lipid levels,..
  20. Boehm E, Zornoza M, Jourdain A, Delmiro Magdalena A, Garcia Consuegra I, Torres Merino R, et al. Role of FAST Kinase Domains 3 (FASTKD3) in Post-transcriptional Regulation of Mitochondrial Gene Expression. J Biol Chem. 2016;291:25877-25887 pubmed
    ..of FASTKD3 resulted in increased steady-state levels and half-lives of a subset of mature mitochondrial mRNAs: ND2, ND3, CYTB, COX2, and ATP8/6. No aberrant processing of RNA precursors was observed...
  21. Wickramasinghe N, Robin V, Ramakrishnan U, Reddy S, Seneviratne S. Non-sister Sri Lankan white-eyes (genus Zosterops) are a result of independent colonizations. PLoS ONE. 2017;12:e0181441 pubmed publisher
    ..Maximum Likelihood and Bayesian phylogenetic analyses with ~2000bp from two mitochondrial (ND2 and ND3) and one nuclear (TGF) gene indicated that they are phylogenetically distinct, and not sister to each other...
  22. Stiburek L, Cesnekova J, Kostková O, Fornuskova D, Vinsova K, Wenchich L, et al. YME1L controls the accumulation of respiratory chain subunits and is required for apoptotic resistance, cristae morphogenesis, and cell proliferation. Mol Biol Cell. 2012;23:1010-23 pubmed publisher
    ....
  23. Feng S, Xiong L, Ji Z, Cheng W, Yang H. Correlation between increased ND2 expression and demethylated displacement loop of mtDNA in colorectal cancer. Mol Med Rep. 2012;6:125-30 pubmed publisher
    ..Quantitative change in ND2 (a subunit of NADH) and the methylation status of the D-loop were observed during the initiation and ..
  24. Richter G, Sonnenschein A, Grunewald T, Reichmann H, Janetzky B. Novel mitochondrial DNA mutations in Parkinson's disease. J Neural Transm (Vienna). 2002;109:721-9 pubmed
    ..As complex I genes are the most vulnerable part of mtDNA we analyzed the mitochondrial MTND1 and MTND2 genes of 10 substantia nigra and 85 platelet samples from PD patients...
  25. Kato C, Umekage T, Tochigi M, Otowa T, Hibino H, Ohtani T, et al. Mitochondrial DNA polymorphisms and extraversion. Am J Med Genet B Neuropsychiatr Genet. 2004;128B:76-9 pubmed
    ..042). Although further studies are recommended for the confirmation, the result may suggest a role of the mitochondrial DNA polymorphism in the personality trait. ..
  26. Karin B, Das I, Jackman T, Bauer A. Ancient divergence time estimates in Eutropis rugifera support the existence of Pleistocene barriers on the exposed Sunda Shelf. Peerj. 2017;5:e3762 pubmed publisher
    ..In this study, we sequenced one mitochondrial (ND2) and four nuclear (BRCA1, BRCA2, RAG1, and MC1R) markers and generated a time-..
  27. Andrews R, Kubacka I, Chinnery P, Lightowlers R, Turnbull D, Howell N. Reanalysis and revision of the Cambridge reference sequence for human mitochondrial DNA. Nat Genet. 1999;23:147 pubmed
  28. Fuke S, Kametani M, Kato T. Quantitative analysis of the 4977-bp common deletion of mitochondrial DNA in postmortem frontal cortex from patients with bipolar disorder and schizophrenia. Neurosci Lett. 2008;439:173-7 pubmed publisher
    ..509). These results indicate that aging and sex have effect on accumulation of the common deletion of mtDNA in the prefrontal cortex depending on the diagnosis. ..
  29. Zhong Y, Chaudhary V, Tan X, Parmar H, Ramanujan R. Mechanochemical synthesis of high coercivity Nd2(Fe,Co)14B magnetic particles. Nanoscale. 2017;: pubmed publisher
    ..It was found that unlike self-propagating reactions, this reduction reaction during milling requires continuous input of mechanical energy to reach a steady state. ..
  30. Chakraborty S, Uddin A, Mazumder T, Choudhury M, Malakar A, Paul P, et al. Codon usage and expression level of human mitochondrial 13 protein coding genes across six continents. Mitochondrion. 2017;: pubmed publisher
    ..a major role while mutation pressure might have played a dominant role in the codon usage bias of ATP8, COII, ND1, ND2, ND3, ND5 and ND6 genes...
  31. Chomyn A, Mariottini P, Cleeter M, Ragan C, Matsuno Yagi A, Hatefi Y, et al. Six unidentified reading frames of human mitochondrial DNA encode components of the respiratory-chain NADH dehydrogenase. Nature. 1985;314:592-7 pubmed
    ..We conclude that the six reading frames encode components of the respiratory-chain NADH dehydrogenase. ..
  32. Ye C, Shu X, Wen W, Pierce L, Courtney R, Gao Y, et al. Quantitative analysis of mitochondrial DNA 4977-bp deletion in sporadic breast cancer and benign breast diseases. Breast Cancer Res Treat. 2008;108:427-34 pubmed
    ..These results do not support the notion that the mitochondrial DNA 4977-bp deletion plays a major role in breast carcinogenesis. ..
  33. Botto N, Berti S, Manfredi S, Al Jabri A, Federici C, Clerico A, et al. Detection of mtDNA with 4977 bp deletion in blood cells and atherosclerotic lesions of patients with coronary artery disease. Mutat Res. 2005;570:81-8 pubmed
    ..The obtained results may suggest that the increase of oxidative stress in cardiovascular disease may be responsible for the accumulation of mtDNA damage in coronary artery disease patients. ..
  34. Castri L, Melendez Obando M, Villegas Palma R, Barrantes R, Raventos H, Pereira R, et al. Mitochondrial polymorphisms are associated both with increased and decreased longevity. Hum Hered. 2009;67:147-53 pubmed publisher
    ..While our data confirm that mtDNA make up affects longevity, they also indicate that the time period in which a person was born had a much greater impact on longevity than presence or absence of a marker. ..
  35. Kazuno A, Munakata K, Mori K, Nanko S, Kunugi H, Nakamura K, et al. Mitochondrial DNA haplogroup analysis in patients with bipolar disorder. Am J Med Genet B Neuropsychiatr Genet. 2009;150B:243-7 pubmed publisher
    ..However, this association was not replicated in an independent sample set. Possible significances of these findings are discussed. ..
  36. Velez D, Menon R, Simhan H, Fortunato S, Canter J, Williams S. Mitochondrial DNA variant A4917G, smoking and spontaneous preterm birth. Mitochondrion. 2008;8:130-5 pubmed
    ..Our data, although preliminary, support the hypothesis that mitochondrial genome polymorphisms may play a significant role in PTB through an interaction with smoking. ..
  37. Michael J, Wurtzel J, Mao G, Rao A, Kolpakov M, Sabri A, et al. Platelet microparticles infiltrating solid tumors transfer miRNAs that suppress tumor growth. Blood. 2017;130:567-580 pubmed publisher
    ..We identified direct RNA targets of platelet-derived miR-24 in tumor cells, which included mitochondrial mt-Nd2, and Snora75, a noncoding small nucleolar RNA...
  38. Kawamoto T, Kokaze A, Ishikawa M, Matsunaga N, Karita K, Yoshida M, et al. Joint effect of longevity-associated mitochondrial DNA 5178 C/A polymorphism and alcohol consumption on risk of hyper-LDL cholesterolemia in middle-aged Japanese men. Lipids Health Dis. 2011;10:105 pubmed publisher
    ..For Mt5178C genotypic men, alcohol consumption may reduce the risk of hyper-LDL cholesterolemia. ..
  39. Canter J, Olson L, Spencer K, Schnetz Boutaud N, Anderson B, Hauser M, et al. Mitochondrial DNA polymorphism A4917G is independently associated with age-related macular degeneration. PLoS ONE. 2008;3:e2091 pubmed publisher
    The objective of this study was to determine if MTND2*LHON4917G (4917G), a specific non-synonymous polymorphism in the mitochondrial genome previously associated with neurodegenerative phenotypes, is associated with increased risk for ..
  40. Canter J, Norris P, Moore J, Jenkins J, Morris J. Specific polymorphic variation in the mitochondrial genome and increased in-hospital mortality after severe trauma. Ann Surg. 2007;246:406-11; discussion 411-4 pubmed
    ..Variation in the mtDNA, specifically the 4216T allele, appears to increase the risk of in-hospital mortality after severe injury. ..
  41. Carneiro L, Bravo G, Aristizabal N, Cuervo A, Aleixo A. Molecular systematics and biogeography of lowland antpittas (Aves, Grallariidae): The role of vicariance and dispersal in the diversification of a widespread Neotropical lineage. Mol Phylogenet Evol. 2017;: pubmed publisher
    ..genera Hylopezus and Myrmothera (Grallariidae), based on sequence data (3139 base pairs) from two mitochondrial (ND2 and ND3) and three nuclear markers (TGFB2, MUSK and FGB-I5) from 142 individuals of the 12 currently recognized ..
  42. Swerdlow R, Weaver B, Grawey A, Wenger C, Freed E, Worrall B. Complex I polymorphisms, bigenomic heterogeneity, and family history in Virginians with Parkinson's disease. J Neurol Sci. 2006;247:224-30 pubmed
    ..gene polymorphisms alternatively reported to associate and not associate with PD (tRNA(Gln) T4336C, ND1 T4216C, ND2 G5460A, and the NDUFV2 exon 2 C182T transition)...