Gene Symbol: ND2
Description: MTND2
Alias: MTND2, MTND2, NADH dehydrogenase subunit 2
Species: human
Products:     ND2

Top Publications

  1. Kokaze A, Ishikawa M, Matsunaga N, Yoshida M, Sekine Y, Sekiguchi K, et al. Longevity-associated mitochondrial DNA 5178 A/C polymorphism influences effects of cigarette smoking on serum protein fraction levels in Japanese men. Mech Ageing Dev. 2003;124:765-70 pubmed
    ..These results suggest that longevity-associated mt5178 A/C polymorphism may influence the effects of cigarette smoking on serum protein fraction levels in healthy Japanese men. ..
  2. Ohkubo R, Nakagawa M, Ikeda K, Kodama T, Arimura K, Akiba S, et al. Cerebrovascular disorders and genetic polymorphisms: mitochondrial DNA5178C is predominant in cerebrovascular disorders. J Neurol Sci. 2002;198:31-5 pubmed
    ..Although the number of CVD patients in the present study was too small to make a final conclusion, mt5178C might be one of the genetic factors to be considered in Japanese patients with CVD. ..
  3. Kokaze A, Ishikawa M, Matsunaga N, Yoshida M, Sekine Y, Sekiguchi K, et al. Longevity-associated mitochondrial DNA 5178 A/C polymorphism and blood pressure in the Japanese population. J Hum Hypertens. 2004;18:41-5 pubmed
    ..been reported that the mitochondrial DNA 5178 adenine/cytosine (mt5178 A/C) polymorphism, also called NADH dehydrogenase subunit 2-237 methionine/leucine (ND2-237 Met/Leu) polymorphism, may be associated with longevity in Japanese ..
  4. Kokaze A, Yoshida M, Ishikawa M, Matsunaga N, Makita R, Satoh M, et al. Longevity-associated mitochondrial DNA 5178 A/C polymorphism is associated with intraocular pressure in Japanese men. Clin Exp Ophthalmol. 2004;32:131-6 pubmed
    ..020), while daily alcohol consumption was significantly associated with IOP in those with mt5178 C (P for trend = 0.021). Longevity-associated mitochondrial DNA 5178 A/C polymorphism may be associated with IOP in Japanese men. ..
  5. Kokaze A, Ishikawa M, Matsunaga N, Yoshida M, Makita R, Satoh M, et al. Longevity-associated mitochondrial DNA 5178 C/A polymorphism is associated with fasting plasma glucose levels and glucose tolerance in Japanese men. Mitochondrion. 2005;5:418-25 pubmed
    ..The present results suggest that Mt5178 C/A polymorphism may be associated with FPG levels and glucose tolerance in middle-aged Japanese men. ..
  6. Kokaze A, Ishikawa M, Matsunaga N, Yoshida M, Satoh M, Teruya K, et al. NADH dehydrogenase subunit-2 237 Leu/Met polymorphism modifies the effects of alcohol consumption on risk for hypertension in middle-aged Japanese men. Hypertens Res. 2007;30:213-8 pubmed
    NADH dehydrogenase subunit-2 237 leucine/methionine (ND2-237 Leu/Met) polymorphism is associated with longevity in the Japanese population, and the ND2-237Met genotype may exert antiatherogenic effects...
  7. Anderson S, Bankier A, Barrell B, de Bruijn M, Coulson A, Drouin J, et al. Sequence and organization of the human mitochondrial genome. Nature. 1981;290:457-65 pubmed
  8. Wang D, Taniyama M, Suzuki Y, Katagiri T, Ban Y. Association of the mitochondrial DNA 5178A/C polymorphism with maternal inheritance and onset of type 2 diabetes in Japanese patients. Exp Clin Endocrinol Diabetes. 2001;109:361-4 pubmed
    ..5 +/- 10.0 years; P = 0.0073). The mt5178A/C polymorphism may be associated with maternal inheritance of type 2 diabetes and may influence the age at onset through deterioration of mitochondrial function. ..
  9. Kokaze A, Ishikawa M, Matsunaga N, Yoshida M, Sekine Y, Teruya K, et al. Association of the mitochondrial DNA 5178 A/C polymorphism with serum lipid levels in the Japanese population. Hum Genet. 2001;109:521-5 pubmed
    ..Mt5178 A seems to have an antiatherogenic effect. This is the first genetic epidemiological report on the association of mt5178 A/C polymorphism with serum lipid levels in the Japanese population. ..

More Information

Publications107 found, 100 shown here

  1. Mukae S, Aoki S, Itoh S, Sato R, Nishio K, Iwata T, et al. Mitochondrial 5178A/C genotype is associated with acute myocardial infarction. Circ J. 2003;67:16-20 pubmed
    ..This particular polymorphism was found to be associated with development of AMI, especially in younger patients and constitutes a new risk factor for AMI. ..
  2. Takagi K, Yamada Y, Gong J, Sone T, Yokota M, Tanaka M. Association of a 5178C-->A (Leu237Met) polymorphism in the mitochondrial DNA with a low prevalence of myocardial infarction in Japanese individuals. Atherosclerosis. 2004;175:281-6 pubmed
    ..demonstrated that a C --> A transversion in mitochondrial DNA (mtDNA) at nucleotide 5178 of the NADH dehydrogenase subunit 2 (ND2) gene, which results in a Lue --> Met substitution at amino acid 237, was found more frequently ..
  3. Kokaze A, Ishikawa M, Matsunaga N, Yoshida M, Makita R, Satoh M, et al. Interaction between longevity-associated mitochondrial DNA 5178 C/A polymorphism and cigarette smoking on hematological parameters in Japanese men. Arch Gerontol Geriatr. 2005;40:113-22 pubmed
    Mitochondrial DNA 5178 C/A (mt5178 C/A), namely NADH dehydrogenase subunit 2 237 Leu/Met, polymorphism is as reported in literature associated with longevity and susceptibility to ischemic heart disease or cerebrovascular disorders in the ..
  4. Kokaze A, Ishikawa M, Matsunaga N, Yoshida M, Makita R, Satoh M, et al. Longevity-associated NADH dehydrogenase subunit-2 polymorphism and serum electrolyte levels in middle-aged obese Japanese men. Mech Ageing Dev. 2005;126:705-9 pubmed
    ..DNA 5178 cytosine/adenine polymorphism, which is also called NADH dehydrogenase subunit-2 237 leucine/methionine (ND2-237 Leu/Met) polymorphism is associated with Japanese longevity...
  5. Kokaze A, Ishikawa M, Matsunaga N, Yoshida M, Satoh M, Teruya K, et al. Longevity-associated NADH dehydrogenase subunit-2 237 Leu/Met polymorphism influences the effects of alcohol consumption on serum uric acid levels in nonobese Japanese men. J Hum Genet. 2006;51:765-71 pubmed
    NADH dehydrogenase subunit-2 237 leucine/methionine (ND2-237 Leu/Met) polymorphism is reportedly associated with longevity in the Japanese population...
  6. Kokaze A, Ishikawa M, Matsunaga N, Yoshida M, Satoh M, Teruya K, et al. Longevity-associated mitochondrial DNA 5178 C/A polymorphism and its interaction with cigarette consumption are associated with pulmonary function in middle-aged Japanese men. J Hum Genet. 2007;52:680-5 pubmed
    ..Mt5178 C/A polymorphism and its interaction with cigarette consumption may be associated with pulmonary function in Japanese men. ..
  7. Canter J, Haas D, Kallianpur A, Ritchie M, Robbins G, Shafer R, et al. The mitochondrial pharmacogenomics of haplogroup T: MTND2*LHON4917G and antiretroviral therapy-associated peripheral neuropathy. Pharmacogenomics J. 2008;8:71-7 pubmed
    ..Two non-synonymous mitochondrial DNA polymorphisms, MTND1*LHON4216C (4216C) and MTND2*LHON4917G (4917G) were characterized in HIV-infected participants exposed to NRTIs in a randomized clinical trial...
  8. Kokaze A, Ishikawa M, Matsunaga N, Karita K, Yoshida M, Ohtsu T, et al. NADH dehydrogenase subunit-2 237 Leu/Met polymorphism modulates the effects of coffee consumption on the risk of hypertension in middle-aged Japanese men. J Epidemiol. 2009;19:231-6 pubmed
    ..The NADH dehydrogenase subunit-2 237 leucine/methionine (ND2-237 Leu/Met) polymorphism is associated with longevity and modifies the effects of alcohol consumption on blood ..
  9. Abe N, Matsuo K, Makino I. Ascaridia nymphii n. sp. (Nematoda: Ascaridida) from the alimentary tract of a severely emaciated dead cockatiel Nymphicus hollandicus. Parasitol Res. 2015;114:4281-8 pubmed publisher
    ..The mitochondrial NADH dehydrogenase subunit 2 gene (nad2) sequences obtained for four samples were mutually identical. They respectively showed 98...
  10. Kim J, Piao Y, Pak Y, Chung D, Han Y, Hong J, et al. Umbilical cord mesenchymal stromal cells affected by gestational diabetes mellitus display premature aging and mitochondrial dysfunction. Stem Cells Dev. 2015;24:575-86 pubmed publisher
    ..a low mitochondrial activity and significantly reduced expression of the mitochondrial function regulatory genes ND2, ND9, COX1, PGC-1α, and TFAM...
  11. Gabl M, Sundqvist M, Holdfeldt A, Lind S, MÃ¥rtensson J, Christenson K, et al. Mitocryptides from Human Mitochondrial DNA-Encoded Proteins Activate Neutrophil Formyl Peptide Receptors: Receptor Preference and Signaling Properties. J Immunol. 2018;200:3269-3282 pubmed publisher
    ..MCTs derived from ND2 and ND4L are very weak neutrophil activators, whereas MCTs from ND1, ATP6, ATP8, COX2, and COX3, do not exert ..
  12. Stiassny M, Denton J, Iyaba R. A new ectoparasitic distichodontid of the genus Eugnathichthys (Characiformes: Citharinoidei) from the Congo basin of central Africa, with a molecular phylogeny for the genus. Zootaxa. 2013;3693:479-90 pubmed
    ..is further diagnosed by four apomorphic, non-synonomous nucleotide transitions in two sampled genes (NADH dehydrogenase subunit 2 and glycosyltransferase)...
  13. Manini T, Buford T, Kairalla J, McDermott M, Vaz Fragoso C, Fielding R, et al. Meta-analysis identifies mitochondrial DNA sequence variants associated with walking speed. GeroScience. 2018;: pubmed publisher
    ..0001) between the m.5460.G>A, ND2 and m.309C>CT, HV2 variants at short and long distances, respectively...
  14. Tranah G, Yokoyama J, Katzman S, Nalls M, Newman A, Harris T, et al. Mitochondrial DNA sequence associations with dementia and amyloid-β in elderly African Americans. Neurobiol Aging. 2014;35:442.e1-8 pubmed publisher
    ..04) when compared with common haplogroup L3. The p.V193I, ND2 substitution was associated with significantly higher Aβ42 levels (p = 0...
  15. Bhatia S, Hirsch K, Baig N, Rodriguez O, Timofeeva O, Kavanagh K, et al. Effects of altered ephrin-A5 and EphA4/EphA7 expression on tumor growth in a medulloblastoma mouse model. J Hematol Oncol. 2015;8:105 pubmed publisher
    ..Our in vivo data establish that in ND2-SmoA1 transgenic mice, the homozygous deletion of ephrin-A5 resulted in a consistent pattern of tumor growth ..
  16. Singh I, Faruq M, Padma M, Goyal V, Behari M, Grover A, et al. Investigation of mitochondrial DNA variations among Indian Friedreich's ataxia (FRDA) patients. Mitochondrion. 2015;25:1-5 pubmed publisher
    ..03). A non-synonymous variation (p. L237M) in ND2 was over-represented among FRDA cases (p-value 0.04)...
  17. Boehm E, Zornoza M, Jourdain A, Delmiro Magdalena A, Garcia Consuegra I, Torres Merino R, et al. Role of FAST Kinase Domains 3 (FASTKD3) in Post-transcriptional Regulation of Mitochondrial Gene Expression. J Biol Chem. 2016;291:25877-25887 pubmed
    ..of FASTKD3 resulted in increased steady-state levels and half-lives of a subset of mature mitochondrial mRNAs: ND2, ND3, CYTB, COX2, and ATP8/6. No aberrant processing of RNA precursors was observed...
  18. Escalona T, Weadick C, Antunes A. Adaptive Patterns of Mitogenome Evolution Are Associated with the Loss of Shell Scutes in Turtles. Mol Biol Evol. 2017;34:2522-2536 pubmed publisher
    ..Positively selected sites were found to be particularly prevalent in OXPHOS Complex I proteins, especially subunit ND2, along both positively selected lineages, consistent with convergent adaptive evolution...
  19. Jebb D, Foley N, Puechmaille S, Teeling E. The complete mitochondrial genome of the Greater Mouse-Eared bat, Myotis myotis (Chiroptera: Vespertilionidae). Mitochondrial DNA A DNA Mapp Seq Anal. 2017;28:347-349 pubmed publisher
    ..All protein-coding genes start with the ATG start codon, except for ND2, ND3, and ND5 which begin with ATT or ATA...
  20. Zhou T, Shen X, Irwin D, Shen Y, Zhang Y. Mitogenomic analyses propose positive selection in mitochondrial genes for high-altitude adaptation in galliform birds. Mitochondrion. 2014;18:70-5 pubmed publisher
    ..Selective analyses revealed significant evidence for positive selection in the genes ND2, ND4, and ATP6 in three of the high-altitude lineages...
  21. Xie J, Wang Q, Zhang T, Yin S, Zhang C, Ge Z. Repeated superovulation may affect mitochondrial functions of cumulus cells in mice. Sci Rep. 2016;6:31368 pubmed publisher
    ..We also found that the mRNA expression of COX1, CYTB, ND2, and ND4 was altered by repeated superovulation in cumulus cells...
  22. Hao Y, Zou Y, Ding Y, Xu W, Yan Z, Li X, et al. Complete mitochondrial genomes of Anopheles stephensi and An. dirus and comparative evolutionary mitochondriomics of 50 mosquitoes. Sci Rep. 2017;7:7666 pubmed publisher
    ..PCGs show signals of purifying selection, but evidence for positive selection in ND2, ND4 and ND6 is found...
  23. Chakraborty S, Uddin A, Mazumder T, Choudhury M, Malakar A, Paul P, et al. Codon usage and expression level of human mitochondrial 13 protein coding genes across six continents. Mitochondrion. 2018;42:64-76 pubmed publisher
    ..a major role while mutation pressure might have played a dominant role in the codon usage bias of ATP8, COII, ND1, ND2, ND3, ND5 and ND6 genes...
  24. Yuan Z, Wu Y, Zhou J, Che J. A new species of the genus <i>Paramesotriton</i> (Caudata: Salamandridae) from Fujian, southeastern China. Zootaxa. 2016;4205:zootaxa.4205.6.3 pubmed publisher
    ..8% at the ND2 gene fragment analyzed...
  25. Dang X, Xia Y, Xu Q, Zhang J. The complete mitochondrial genome of the Poecilia formosa (Amazon molly). Mitochondrial DNA A DNA Mapp Seq Anal. 2016;27:3523-4 pubmed publisher
    ..codon was a single T- - base in most of the protein-coding genes, but COX2 and ATP8 both employed TAA and ND2 terminated with AGG codon. Phylogenetic tree was constructed based on the complete mitogenome of P...
  26. Wang N, Liang B. Complete mitochondrial genome of a sunbird, Aethopyga gouldiae (Aves: Passeriformes), the first representative of Nectariniidae. Mitochondrial DNA A DNA Mapp Seq Anal. 2016;27:2356-8 pubmed publisher
    ..ribosomal RNA and protein-coding gene, and by estimating its phylogenetic position using five genes (12S, ND2, ATP6, ND3, CYTb) and 52 passerines (including 17 sunbirds and allies). The mitogenomic length of A...
  27. Tech K, Tikunov A, Farooq H, Morrissy A, Meidinger J, Fish T, et al. Pyruvate Kinase Inhibits Proliferation during Postnatal Cerebellar Neurogenesis and Suppresses Medulloblastoma Formation. Cancer Res. 2017;77:3217-3230 pubmed publisher
    ..i>Pkm2 deletion accelerated tumor formation in medulloblastoma-prone ND2:SmoA1 mice, indicating the disrupting PKM releases CGNPs from a tumor-suppressive effect...
  28. Thor T, Künkele A, Pajtler K, Wefers A, Stephan H, Mestdagh P, et al. MiR-34a deficiency accelerates medulloblastoma formation in vivo. Int J Cancer. 2015;136:2293-303 pubmed publisher
    ..Analysis of miR-34a in medulloblastomas derived from ND2:SmoA1(tg) mice revealed significant suppression of miR-34a compared to normal cerebellum...
  29. Jiang Y, Ellis T, Greenlee A. Genotyping Parkinson disease-associated mitochondrial polymorphisms. Clin Med Res. 2004;2:99-106 pubmed
  30. Weisrock D, Macey J, Matsui M, Mulcahy D, Papenfuss T. Molecular phylogenetic reconstruction of the endemic Asian salamander family Hynobiidae (Amphibia, Caudata). Zootaxa. 2013;3626:77-93 pubmed
    ..two genic regions encoding a 12S-16S region (the 3' end of 12S rRNA, tRNA(VAI), and the 5' end of 16S rRNA), and a ND2-COI region (ND2, tRNA(Trp), tRNA(Ala), tRNA(Asn), the origin for light strand replication--O(L), tRNA(Cys), tRNAT(..
  31. Dai C, Hao Y, He Y, Lei F. The absence of reproductive isolation between non-sister and deeply diverged mitochondrial lineages of the black-throated tit (Aegithalos concinnus) revealed by a multilocus genetic analysis in a contact zone. BMC Evol Biol. 2017;17:266 pubmed publisher
    ..Mitochondrial ND2 and 11 microsatellite loci were used to conduct phylogenetic and population structure analyses...
  32. Siqueira F, Carmo A, Pimentel J, Kalapothakis E. Complete mitochondrial genome sequence of Brycon orbignyanus (Characiformes, Bryconidae). Mitochondrial DNA A DNA Mapp Seq Anal. 2016;27:1942-3 pubmed publisher
    ..Seven PCGs had incomplete stop codons: specifically, Cox2, Cox3, Nd3, Nd4, and Cytb contained the T- - codon, and Nd2 and Atp6 contained the TA- codon. The Cox1 gene contained the AGG stop codon.
  33. Liu F, Bao X, Fan Y, Li J. Sequencing and analysis of the complete mitochondrial genome of Rufous-tailed Shrike, Lanius isabellinus (Passeriformes, Laniidae). Mitochondrial DNA A DNA Mapp Seq Anal. 2016;27:2625-6 pubmed publisher
    ..with the Black-headed Gull (Chroicocephalus ridibundus) and the Grey-backed Shrike (Lanius tephronotus), except for ND2 that was terminated with TAG...
  34. Kim M, Hong E, Kim I. Complete mitochondrial genome of Camponotus atrox (Hymenoptera: Formicidae): a new tRNA arrangement in Hymenoptera. Genome. 2016;59:59-74 pubmed publisher
    ..The C. atrox mt genome had a unique gene arrangement, trnI-trnM-trnQ, at the A+T-rich region and ND2 junction (underline indicates inverted gene)...
  35. Agarwal I. Two new species of ground-dwelling <i>Cyrtodactylus</i> (<i>Geckoella</i>) from the Mysore Plateau, south India. Zootaxa. 2016;4193:zootaxa.4193.2.2 pubmed publisher
    ..The new species are members of the C. collegalensis species complex, with 8.7 % uncorrected ND2 sequence divergence from each other and greater than 10 % divergence from described members of the C...
  36. Han H, Zhou X, Pang B. The complete mitochondrial genome of Angaracris barabensis Pallas (Orthoptera: Acridoidea). Mitochondrial DNA A DNA Mapp Seq Anal. 2016;27:1827-8 pubmed publisher
    ..the start codon ATN, and the usual termination codons (TAA) are found from 13 protein-coding genes, except for ND2, COII, ND3 (T). All of the 22 typical animal tRNA genes were found in A...
  37. He K, Hu N, Chen X, Li J, Jiang X. Interglacial refugia preserved high genetic diversity of the Chinese mole shrew in the mountains of southwest China. Heredity (Edinb). 2016;116:23-32 pubmed publisher
    ..Two mitochondrial genes, namely, cytochrome b (CYT B) and NADH dehydrogenase subunit 2 (ND2), from 383 archived specimens from 43 localities were determined for phylogeographic and ..
  38. Wen J, Lee J, Malhotra A, Nahta R, Arnold A, Buss M, et al. WIP1 modulates responsiveness to Sonic Hedgehog signaling in neuronal precursor cells and medulloblastoma. Oncogene. 2016;35:5552-5564 pubmed publisher
    ..we developed a mouse in which WIP1 is expressed in the developing brain under control of the Neurod2 promoter (ND2:WIP1)...
  39. Zhang P, Fang H, Pan W, Pan H. The complete mitochondrial genome of Chinese pond mussel Sinanodonta woodiana (Unionoida: Unionidae). Mitochondrial DNA A DNA Mapp Seq Anal. 2016;27:1620-1 pubmed publisher
    ..F ORF (Female-specific open reading frame) begins with ATA, Cyt b begins with ATC, ATP6, ATP8, COII, COIII, ND1, ND2, ND3 and ND5 begin with ATG, ND4L begins with GTG, COI begins with TTG, and other two protein-coding genes begin ..
  40. Liu P, Zhu D, Zhao W, Ji X. The complete mitochondrial genome of the common lizard Zootoca vivipara (Squamata: Lacertidae). Mitochondrial DNA A DNA Mapp Seq Anal. 2016;27:1944-5 pubmed publisher
    ..ND1, ATP8, ATP6, ND4L, ND5 and Cyt b genes are terminated with TAA as stop codon, ND2 ends with TAG, COI and ND6 end with AGG, and the other four protein-coding genes end with an incomplete stop codon (..
  41. Tian X, Liu J, Cui Y, Dong P, Zhu Y. Mitochondrial genome of one kind of giant Asian mantis, Hierodula formosana (Mantodea: Mantidae). Mitochondrial DNA A DNA Mapp Seq Anal. 2017;28:11-12 pubmed publisher
    ..8%. An extra non-coding region is inserted between trnM and ND2, similar to the other Mantidae species T. tamolana...
  42. Qu M, Tang W, Liu Q, Wang D, Ding S. Genetic diversity within grouper species and a method for interspecific hybrid identification using DNA barcoding and RYR3 marker. Mol Phylogenet Evol. 2018;121:46-51 pubmed publisher
    ..Both mitochondrial (mt) cytochrome oxidase subunit I (COI) and NADH dehydrogenase subunit 2 (ND2) were found to be effective barcoding genes...
  43. Wise C, Sraml M, Easteal S. Departure from neutrality at the mitochondrial NADH dehydrogenase subunit 2 gene in humans, but not in chimpanzees. Genetics. 1998;148:409-21 pubmed
    ..a neutral model of molecular evolution, nucleotide sequences were determined for the 1041 bp of the NADH dehydrogenase subunit 2 (ND2) gene in 20 geographically diverse humans and 20 common chimpanzees...
  44. Neto J, Arroyo J, Bargain B, Monrós J, Mátrai N, Procházka P, et al. Phylogeography of a habitat specialist with high dispersal capability: the Savi's Warbler Locustella luscinioides. PLoS ONE. 2012;7:e38497 pubmed publisher
    ..mobile, but specialized, passerine, the Savi's Warbler (Locustella luscinioides), mitochondrial DNA sequences (ND2) and microsatellites were analysed in c.330 individuals of 17 breeding and two wintering populations...
  45. Cliff H, Wapstra E, Burridge C. Persistence and dispersal in a Southern Hemisphere glaciated landscape: the phylogeography of the spotted snow skink (Niveoscincus ocellatus) in Tasmania. BMC Evol Biol. 2015;15:121 pubmed publisher
    ..ocellatus were surveyed for variation at two mitochondrial genes (ND2, ND4), and two nuclear genes (β-globin, RPS8)...
  46. Nichols M, Zhang J, Polster B, Elustondo P, Thirumaran A, Pavlov E, et al. Synergistic neuroprotection by epicatechin and quercetin: Activation of convergent mitochondrial signaling pathways. Neuroscience. 2015;308:75-94 pubmed publisher
    ..Consistent with these findings, E+Q (0.1 and 1.0μM) elevated mitochondrial gene expression (MT-ND2 and MT-ATP6) to a greater extent than E or Q after OGD. Q (0.3-3.0μM), but not E (3...
  47. Al Kafaji G, Sabry M, Bakhiet M. Increased expression of mitochondrial DNA-encoded genes in human renal mesangial cells in response to high glucose-induced reactive oxygen species. Mol Med Rep. 2016;13:1774-80 pubmed publisher
    ..The mRNA expression levels of nicotinamide adenine dinucleotide dehydrogenase 2 (ND2) of complex I, cytochrome b (CYTB) of complex III, cytochrome c oxidase (COI) of complex IV and ATPase 6 of complex ..
  48. Cobos A, Grismer L, Wood P, Quah E, Anuar S, Muin M. Phylogenetic relationships of geckos of the Hemiphyllodactylus harterti group, a new species from Penang Island, Peninsular Malaysia, and a likely case of true cryptic speciation. Zootaxa. 2016;4107:367-80 pubmed publisher
    An integrative taxonomic analysis based on the mitochondrial gene ND2 and its flanking tRNAs, morphology, and color pattern indicates that a newly discovered gecko described herein as Hemiphyllodactylus cicak sp. nov...
  49. Persad P, Heid I, Weeks D, Baird P, de Jong E, Haines J, et al. Joint Analysis of Nuclear and Mitochondrial Variants in Age-Related Macular Degeneration Identifies Novel Loci TRPM1 and ABHD2/RLBP1. Invest Ophthalmol Vis Sci. 2017;58:4027-4038 pubmed publisher
    ..0 × 10-8) of two intronic TRPM1 nSNPs and AMD-associated nonsynonymous MT-ND2 mtSNP A4917G...
  50. McCarty C, Fuchs M, Lamb A, Conway P. How Do Patients Respond to Genetic Testing for Age-related Macular Degeneration?. Optom Vis Sci. 2018;95:166-170 pubmed publisher
    ..SNPs) in the CFH gene, one SNP in the ARMS-2 gene, one SNP in the C3 gene, and one SNP in the mitochondrial ND2 gene...
  51. Shao Z, Li T, Jiang J, Lu J, Chen H. Molecular phylogenetic analysis of the Amiota taurusata species group within the Chinese species, with descriptions of two new species. J Insect Sci. 2014;14:33 pubmed publisher
    ..Drosophilidae) species group were investigated based on DNA sequence data of the mitochondrial NADH dehydrogenase subunit 2 ( ND2) gene, using three species of the genus Amiota as outgroups...
  52. Huang J, Su Y, Zhao J, Liu X, Wang Z. The complete mitogenome sequence of Pseudohynobius jinfo (Urodela: Hynobiidae). Mitochondrial DNA A DNA Mapp Seq Anal. 2016;27:3141-2 pubmed publisher
    ..The gene order and composition of P. jinfo was similar to that of the most Hynobiidae. Seven genes (ND1, ND2, COII, COIII, ND3, ND4 and Cytb) had an incomplete stop codon. Base composition of the genome was A (33.6%), T (31...
  53. Presti F, Guedes N, Antas P, Miyaki C. Population Genetic Structure in Hyacinth Macaws (Anodorhynchus hyacinthinus) and Identification of the Probable Origin of Confiscated Individuals. J Hered. 2015;106 Suppl 1:491-502 pubmed publisher
    ..based on 10 microsatellites from 98 individuals and 2123bp of mitochondrial sequence (ND5, cytochrome b, and ND2) from 80 individuals...
  54. Jeong S, Kim M, Kim S, Kim I. Complete mitochondrial genome of the endangered Lycaenid butterfly Shijimiaeoides divina (Lepidoptera: Lycaenidae). Mitochondrial DNA A DNA Mapp Seq Anal. 2017;28:242-243 pubmed publisher
    ..non-coding AT-rich region, with an arrangement typical of Ditrysia (trnM-trnI-trnQ between the AT-rich region and ND2). The 379-bp A?+?T-rich region has a trnK-like sequence...
  55. González Rubio C, García de León F, Rodríguez Estrella R. Phylogeography of endemic Xantus' hummingbird (Hylocharis xantusii) shows a different history of vicariance in the Baja California Peninsula. Mol Phylogenet Evol. 2016;102:265-77 pubmed publisher
    ..California Peninsula, Hylocharis xantusii, mitochondrial DNA sequences of three concatenated genes (Cyt-b, COI and ND2; 2297bp in total) in 100 individuals were analyzed...
  56. Ogasawara M, Liu J, Pelicano H, Hammoudi N, Croce C, Keating M, et al. Alterations of mitochondrial biogenesis in chronic lymphocytic leukemia cells with loss of p53. Mitochondrion. 2016;31:33-39 pubmed publisher
    ..Although the expression of mitochondrial COX1, ND2, and ND6 decreased in p53-/-CLL cells, there was an increase in mitochondrial biogenesis as evidenced by ..
  57. Urantowka A, Kroczak A, Mackiewicz P. The influence of molecular markers and methods on inferring the phylogenetic relationships between the representatives of the Arini (parrots, Psittaciformes), determined on the basis of their complete mitochondrial genomes. BMC Evol Biol. 2017;17:166 pubmed publisher
    ..A significant disagreement in these tree topologies occurred for cytb, nd2 and nd6 genes, which are commonly used in parrot phylogenies...
  58. Ugalde C, Hinttala R, Timal S, Smeets R, Rodenburg R, Uusimaa J, et al. Mutated ND2 impairs mitochondrial complex I assembly and leads to Leigh syndrome. Mol Genet Metab. 2007;90:10-4 pubmed
    We describe a novel mitochondrial ND2 mutation (T4681C) in a patient presenting with Leigh Syndrome. Biochemical analyses revealed a low isolated complex I activity in patient's fibroblasts, blood and skeletal muscle...
  59. Webb E, Broderick P, Chandler I, Lubbe S, Penegar S, Tomlinson I, et al. Comprehensive analysis of common mitochondrial DNA variants and colorectal cancer risk. Br J Cancer. 2008;99:2088-93 pubmed publisher
    ..In conclusion, our results provide little evidence that mitochondrial genetic background plays a role in modifying an individual's risk of developing CRC. ..
  60. Ochoa A, Onorato D, Fitak R, Roelke Parker M, Culver M. Evolutionary and Functional Mitogenomics Associated With the Genetic Restoration of the Florida Panther. J Hered. 2017;108:449-455 pubmed publisher
    ..We directly and indirectly assessed the presence of potential deleterious SNPs in the ND2 and ND5 genes in Florida panthers prior to and as a consequence of the introduction of Texas pumas...
  61. Washizuka S, Ikeda A, Kato N, Kato T. Possible relationship between mitochondrial DNA polymorphisms and lithium response in bipolar disorder. Int J Neuropsychopharmacol. 2003;6:421-4 pubmed
    ..05). Our findings suggest that the mtDNA 10398 polymorphism might be related to maintenance lithium treatment response. ..
  62. Gingrich J, Pelkey K, Fam S, Huang Y, Petralia R, Wenthold R, et al. Unique domain anchoring of Src to synaptic NMDA receptors via the mitochondrial protein NADH dehydrogenase subunit 2. Proc Natl Acad Sci U S A. 2004;101:6237-42 pubmed
    ..Here, we show that the unique domain of Src is a protein-protein interaction region and we identify NADH dehydrogenase subunit 2 (ND2) as a Src unique domain-interacting protein...
  63. Liao W, Pang Y, Yu C, Wen J, Zhang Y, Li X. Novel mutations of mitochondrial DNA associated with type 2 diabetes in Chinese Han population. Tohoku J Exp Med. 2008;215:377-84 pubmed
    ..0006, OR 0.06 [95% CI 0.008-0.476]). MtSNPs T3394C in NADH dehydrogenase subunit 1 (ND1), G4491A in ND2, T16189C and T16519C were found with significantly higher frequency in patients with T2DM than in the controls (..
  64. Honmyo R, Kokaze A, Karita K, Yoshida M, Ishikawa M, Ohno H. Influence of mitochondrial DNA 5178 C/A polymorphism on serum cholesterol changes: a short-term follow-up in middle-aged Japanese men. Environ Health Prev Med. 2012;17:401-7 pubmed publisher
    ..015). The Mt5178 C/A genotype may modify longitudinal changes in serum TC and HDLC levels in middle-aged Japanese men. ..
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    ..closest to the transcription start site of the polycistronic heavy chain mitochondrial transcript (MT-ND1, MT-ND2, MT-ATP6, MT-CO1, MT-CO2, MT-C03) and MT-ND6 transcribed from the light chain...
  66. KrzemiÅ„ska U, Morales H, Greening C, Nyári Ã, Wilson R, Song B, et al. Population mitogenomics provides insights into evolutionary history, source of invasions and diversifying selection in the House Crow (Corvus splendens). Heredity (Edinb). 2018;120:296-309 pubmed publisher
    ..of selection and assessments of changes in amino acid properties provide evidence of positive selection on the ND2 and ND5 genes against a background of purifying selection across the mitogenome...
  67. Woo H, Nguyen A, Jang K, Choi E, Ryu S, Hwang U. The complete mitochondrial genome of the Korean endemic millipede <i>Anaulaciulus</i> <i>koreanus</i> (Verhoeff, 1937), with notes on the gene arrangement of millipede orders. Zootaxa. 2017;4329:574-583 pubmed publisher
    ..The absence of tRNACys between the ND2 and COI regions is unique to the order Polydesmida, whereas the translocation of tRNATyr to between ND2 and COI is ..
  68. Kokaze A, Ishikawa M, Matsunaga N, Yoshida M, Sekine Y, Teruya K, et al. Association of the longevity-associated mitochondrial DNA 5178 A/C polymorphism with serum protein fraction levels in healthy Japanese women. Exp Gerontol. 2002;37:931-6 pubmed
    ..However, no such difference was found in males. These results provide the first evidence that the mt5178 A/C polymorphism may influence the serum protein fraction levels of the healthy Japanese women. ..
  69. Lal S, Madhavan M, Heng C. The association of mitochondrial DNA 5178 C > a polymorphism with plasma lipid levels among three ethnic groups. Ann Hum Genet. 2005;69:639-44 pubmed
    ..The C to A nucleotide transversion in the NADH dehydrogenase subunit 2 (MT-ND2) coding region of mitochondrial DNA has been reported to be associated with plasma lipid levels,..
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    ..31; 95% CI: 1.24-14.92; p=0.021). The present results suggest that active prophylactic interventions such as dietary, exercise, and pharmacological therapies should be offered to non-carriers of the Glu allele (Lys/Lys). ..
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    ..Quantitative change in ND2 (a subunit of NADH) and the methylation status of the D-loop were observed during the initiation and ..
  74. Han G, Xia L, Li S, Jin Q, Song Y, Shen H, et al. The Association between the C5263T Mutation in the Mitochondrial ND2 Gene and Coronary Heart Disease among Young Chinese Han People. Biomed Environ Sci. 2017;30:280-287 pubmed publisher
    ..The C5263T single-nucleotide mutation of the mitochondrial ND2 gene was observed in 2 young CHD patients in the case group...
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    ..Maximum Likelihood and Bayesian phylogenetic analyses with ~2000bp from two mitochondrial (ND2 and ND3) and one nuclear (TGF) gene indicated that they are phylogenetically distinct, and not sister to each other...
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    ..For this study, the mitochondrial gene nd2 was amplified from 394 individuals collected from seven different Belizean Cays (N = 175) and eight ..
  77. Drovetski S, Reeves A, Red kin Y, Fadeev I, Koblik E, Sotnikov V, et al. Multi-locus reassessment of a striking discord between mtDNA gene trees and taxonomy across two congeneric species complexes. Mol Phylogenet Evol. 2018;120:43-52 pubmed publisher
    ..To test mtDNA gene tree topology, we sequenced the mtDNA ND2 gene and 11 nuclear introns for seven wagtail species...
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    ..As complex I genes are the most vulnerable part of mtDNA we analyzed the mitochondrial MTND1 and MTND2 genes of 10 substantia nigra and 85 platelet samples from PD patients...
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    ..042). Although further studies are recommended for the confirmation, the result may suggest a role of the mitochondrial DNA polymorphism in the personality trait. ..
  81. Fuke S, Kametani M, Kato T. Quantitative analysis of the 4977-bp common deletion of mitochondrial DNA in postmortem frontal cortex from patients with bipolar disorder and schizophrenia. Neurosci Lett. 2008;439:173-7 pubmed publisher
    ..509). These results indicate that aging and sex have effect on accumulation of the common deletion of mtDNA in the prefrontal cortex depending on the diagnosis. ..
  82. Yang X, Zhang Y, Ma Y, Zhao Q, Lyu J. [Effect of mitochondrial DNA 5178 C/A polymorphism on risks for type 2 diabetes mellitus and its complications]. Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2015;32:855-60 pubmed publisher
    To explore the role of mitochondrial DNA 5178 C/A (Mt5178) polymorphism of NADH-dehydrogenase subunit 2 (ND2) gene in type-2 diabetes mellitus (T2DM) among ethnic Han Chinese through a case-control study...
  83. Karin B, Das I, Jackman T, Bauer A. Ancient divergence time estimates in Eutropis rugifera support the existence of Pleistocene barriers on the exposed Sunda Shelf. Peerj. 2017;5:e3762 pubmed publisher
    ..In this study, we sequenced one mitochondrial (ND2) and four nuclear (BRCA1, BRCA2, RAG1, and MC1R) markers and generated a time-..
  84. Chomyn A, Mariottini P, Cleeter M, Ragan C, Matsuno Yagi A, Hatefi Y, et al. Six unidentified reading frames of human mitochondrial DNA encode components of the respiratory-chain NADH dehydrogenase. Nature. 1985;314:592-7 pubmed
    ..We conclude that the six reading frames encode components of the respiratory-chain NADH dehydrogenase. ..
  85. Botto N, Berti S, Manfredi S, Al Jabri A, Federici C, Clerico A, et al. Detection of mtDNA with 4977 bp deletion in blood cells and atherosclerotic lesions of patients with coronary artery disease. Mutat Res. 2005;570:81-8 pubmed
    ..The obtained results may suggest that the increase of oxidative stress in cardiovascular disease may be responsible for the accumulation of mtDNA damage in coronary artery disease patients. ..
  86. Ye C, Shu X, Wen W, Pierce L, Courtney R, Gao Y, et al. Quantitative analysis of mitochondrial DNA 4977-bp deletion in sporadic breast cancer and benign breast diseases. Breast Cancer Res Treat. 2008;108:427-34 pubmed
    ..These results do not support the notion that the mitochondrial DNA 4977-bp deletion plays a major role in breast carcinogenesis. ..
  87. Velez D, Menon R, Simhan H, Fortunato S, Canter J, Williams S. Mitochondrial DNA variant A4917G, smoking and spontaneous preterm birth. Mitochondrion. 2008;8:130-5 pubmed
    ..Our data, although preliminary, support the hypothesis that mitochondrial genome polymorphisms may play a significant role in PTB through an interaction with smoking. ..
  88. Kazuno A, Munakata K, Mori K, Nanko S, Kunugi H, Nakamura K, et al. Mitochondrial DNA haplogroup analysis in patients with bipolar disorder. Am J Med Genet B Neuropsychiatr Genet. 2009;150B:243-7 pubmed publisher
    ..However, this association was not replicated in an independent sample set. Possible significances of these findings are discussed. ..
  89. Castri L, Melendez Obando M, Villegas Palma R, Barrantes R, Raventos H, Pereira R, et al. Mitochondrial polymorphisms are associated both with increased and decreased longevity. Hum Hered. 2009;67:147-53 pubmed publisher
    ..While our data confirm that mtDNA make up affects longevity, they also indicate that the time period in which a person was born had a much greater impact on longevity than presence or absence of a marker. ..
  90. Uzawa K, Kasamatsu A, Baba T, Kimura Y, Nakashima D, Higo M, et al. Quantitative detection of circulating tumor-derived mitochondrial NADH subunit variants as a potential prognostic biomarker for oral cancer. Int J Oncol. 2015;47:1077-83 pubmed publisher
    ..if the other mut-mtDNAs have novel efficiency for detecting potential tumoral micrometastasis, mut-mtDNAs on the ND2 and ND3 regions of the genome in 240 clinical samples from patients with OSCC were assessed in vitro and in ..
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    ..It was found that unlike self-propagating reactions, this reduction reaction during milling requires continuous input of mechanical energy to reach a steady state. ..