NANOG

Summary

Gene Symbol: NANOG
Description: Nanog homeobox
Alias: homeobox protein NANOG, homeobox transcription factor Nanog, homeobox transcription factor Nanog-delta 48
Species: human
Products:     NANOG

Top Publications

  1. Boyer L, Lee T, Cole M, Johnstone S, Levine S, Zucker J, et al. Core transcriptional regulatory circuitry in human embryonic stem cells. Cell. 2005;122:947-56 pubmed
    The transcription factors OCT4, SOX2, and NANOG have essential roles in early development and are required for the propagation of undifferentiated embryonic stem (ES) cells in culture...
  2. Meng H, Zheng P, Wang X, Liu C, Sui H, Wu S, et al. Over-expression of Nanog predicts tumor progression and poor prognosis in colorectal cancer. Cancer Biol Ther. 2010;9:295-302 pubmed publisher
    We studied the expression and regulatory effects of ESC self-renewal molecule Nanog in colorectal cancer (CRC)...
  3. Wang Z, Teh C, Chan C, Chu C, Rossbach M, Kunarso G, et al. The transcription factor Zfp281 controls embryonic stem cell pluripotency by direct activation and repression of target genes. Stem Cells. 2008;26:2791-9 pubmed publisher
    Oct4, Sox2, and Nanog are key components of a core transcriptional regulatory network that controls the ability of embryonic stem cells to differentiate into all cell types...
  4. Noh K, Lee Y, Jeon J, Kang T, Mao C, Wu T, et al. Cancer vaccination drives Nanog-dependent evolution of tumor cells toward an immune-resistant and stem-like phenotype. Cancer Res. 2012;72:1717-27 pubmed publisher
    ..The emergence of this phenotype required the transcription factor Nanog, which is induced as a consequence of immune selection...
  5. Yang J, Chai L, Fowles T, Alipio Z, Xu D, Fink L, et al. Genome-wide analysis reveals Sall4 to be a major regulator of pluripotency in murine-embryonic stem cells. Proc Natl Acad Sci U S A. 2008;105:19756-61 pubmed publisher
    ..Sall4, a zinc-finger transcription factor, is expressed very early in embryonic development with Oct4 and Nanog, two well-characterized pluripotency regulators...
  6. Das S, Jena S, Levasseur D. Alternative splicing produces Nanog protein variants with different capacities for self-renewal and pluripotency in embryonic stem cells. J Biol Chem. 2011;286:42690-703 pubmed publisher
    ..The homeodomain transcription factor Nanog acts collaboratively with core factors Oct4 and Sox2 to govern the maintenance of pluripotency...
  7. Chan K, Zhang J, Chia N, Chan Y, Sim H, Tan K, et al. KLF4 and PBX1 directly regulate NANOG expression in human embryonic stem cells. Stem Cells. 2009;27:2114-25 pubmed publisher
    ..However, the transcriptional regulation of NANOG itself in hESCs has largely been elusive...
  8. Pan G, Thomson J. Nanog and transcriptional networks in embryonic stem cell pluripotency. Cell Res. 2007;17:42-9 pubmed
    ..quot; A unique homeobox transcription factor, Nanog, is one of the key downstream effectors of these signals...
  9. Chambers I, Colby D, Robertson M, Nichols J, Lee S, Tweedie S, et al. Functional expression cloning of Nanog, a pluripotency sustaining factor in embryonic stem cells. Cell. 2003;113:643-55 pubmed
    ..We applied expression cloning in mouse ES cells to isolate a self-renewal determinant. Nanog is a divergent homeodomain protein that directs propagation of undifferentiated ES cells...

More Information

Publications75

  1. Noh K, Kim B, Song K, Cho H, Lee Y, Kim J, et al. Nanog signaling in cancer promotes stem-like phenotype and immune evasion. J Clin Invest. 2012;122:4077-93 pubmed publisher
    ..and that the CSC-like phenotype arises through the Akt signaling pathway via transcriptional induction of Tcl1a by Nanog. Furthermore, we found that hyperactivation of the Nanog/Tcl1a/Akt signaling axis was conserved across multiple ..
  2. Choi S, Choi J, Park C, Ahn C, Hong S, Lim D. Nanog regulates molecules involved in stemness and cell cycle-signaling pathway for maintenance of pluripotency of P19 embryonal carcinoma stem cells. J Cell Physiol. 2012;227:3678-92 pubmed publisher
    To identify potential downstream targets of Nanog, a key transcription factor in the maintenance of pluripotency of embryonic stem (ES) and embryonal carcinoma (EC) cells, global gene expression profiles in Nanog small interfering RNA (..
  3. Zhou X, Zhou Y, Huang G, Gong B, Yang B, Zhang D, et al. Expression of the stem cell marker, Nanog, in human endometrial adenocarcinoma. Int J Gynecol Pathol. 2011;30:262-70 pubmed publisher
    The embryonic stem cell self-renewal gene, Nanog, has been shown to be expressed in several tumor types and to regulate tumor development...
  4. Han J, Zhang F, Yu M, Zhao P, Ji W, Zhang H, et al. RNA interference-mediated silencing of NANOG reduces cell proliferation and induces G0/G1 cell cycle arrest in breast cancer cells. Cancer Lett. 2012;321:80-8 pubmed publisher
    ..b>NANOG is a homeodomain-containing transcription factor that functions to maintain self-renewal and proliferation of ..
  5. Booth H, Holland P. Eleven daughters of NANOG. Genomics. 2004;84:229-38 pubmed
    b>Nanog is a recently discovered ANTP class homeobox gene. Mouse Nanog is expressed in the inner cell mass and in embryonic stem cells and has roles in self-renewal and maintenance of pluripotency...
  6. Bourguignon L, Earle C, Wong G, Spevak C, Krueger K. Stem cell marker (Nanog) and Stat-3 signaling promote MicroRNA-21 expression and chemoresistance in hyaluronan/CD44-activated head and neck squamous cell carcinoma cells. Oncogene. 2012;31:149-60 pubmed publisher
    ..investigated matrix hyaluronan (HA)-induced CD44 (a primary HA receptor) interaction with the stem cell markers, Nanog and Stat-3, in HNSCC cells (HSC-3 cells)...
  7. Zbinden M, Duquet A, Lorente Trigos A, Ngwabyt S, Borges I, Ruiz i Altaba A. NANOG regulates glioma stem cells and is essential in vivo acting in a cross-functional network with GLI1 and p53. EMBO J. 2010;29:2659-74 pubmed publisher
    A cohort of genes associated with embryonic stem (ES) cell behaviour, including NANOG, are expressed in a number of human cancers...
  8. Bourguignon L, Spevak C, Wong G, Xia W, Gilad E. Hyaluronan-CD44 interaction with protein kinase C(epsilon) promotes oncogenic signaling by the stem cell marker Nanog and the Production of microRNA-21, leading to down-regulation of the tumor suppressor protein PDCD4, anti-apoptosis, and chemotherap. J Biol Chem. 2009;284:26533-46 pubmed publisher
    ..to CD44 promotes PKCepsilon activation, which, in turn, increases the phosphorylation of the stem cell marker, Nanog, in the breast tumor cell line MCF-7...
  9. Kochupurakkal B, Sarig R, Fuchs O, Piestun D, Rechavi G, Givol D. Nanog inhibits the switch of myogenic cells towards the osteogenic lineage. Biochem Biophys Res Commun. 2008;365:846-50 pubmed
    The homeodomain transcription factor Nanog has been implicated in inhibiting differentiation and controlling pluripotency of embryonic stem (ES) cells...
  10. Lu Y, Zhu H, Shan H, Lu J, Chang X, Li X, et al. Knockdown of Oct4 and Nanog expression inhibits the stemness of pancreatic cancer cells. Cancer Lett. 2013;340:113-23 pubmed publisher
    ..This study aimed to investigate the possible involvement of Oct4 and Nanog in pancreatic cancer...
  11. Lin Y, Han Z, Xiong F, Tian L, Wu X, Xue S, et al. Malignant transformation of 293 cells induced by ectopic expression of human Nanog. Mol Cell Biochem. 2011;351:109-16 pubmed publisher
    Tumor development has long been known to resemble abnormal embryogenesis. The ESC self-renewal gene NANOG is purportedly expressed in some epithelial cancer cells and solid tumors, but a casual role in tumor development has remained ..
  12. You J, Kang J, Seo D, Park J, Park J, Lee J, et al. Depletion of embryonic stem cell signature by histone deacetylase inhibitor in NCCIT cells: involvement of Nanog suppression. Cancer Res. 2009;69:5716-25 pubmed publisher
    ..The core stemness gene Nanog is abnormally overexpressed in human embryonic carcinoma NCCIT cells showing gene expression profiles similar to ..
  13. Deb Rinker P, Ly D, Jezierski A, Sikorska M, Walker P. Sequential DNA methylation of the Nanog and Oct-4 upstream regions in human NT2 cells during neuronal differentiation. J Biol Chem. 2005;280:6257-60 pubmed
    ..NT2 cells, which differentiate into neurons and astrocytes, initially express and then permanently down-regulate Nanog and Oct-4 (POU5F1)...
  14. Siu M, Wong E, Chan H, Ngan H, Chan K, Cheung A. Overexpression of NANOG in gestational trophoblastic diseases: effect on apoptosis, cell invasion, and clinical outcome. Am J Pathol. 2008;173:1165-72 pubmed publisher
    ..b>NANOG is an important transcription factor that is crucial for maintaining embryonic stem cell self-renewal and ..
  15. Freberg C, Dahl J, Timoskainen S, Collas P. Epigenetic reprogramming of OCT4 and NANOG regulatory regions by embryonal carcinoma cell extract. Mol Biol Cell. 2007;18:1543-53 pubmed
    ..of DNA methylation and histone modifications on regulatory regions of the developmentally regulated OCT4 and NANOG genes by exposure of 293T cells to EC cell extract...
  16. Hart A, Hartley L, Ibrahim M, Robb L. Identification, cloning and expression analysis of the pluripotency promoting Nanog genes in mouse and human. Dev Dyn. 2004;230:187-98 pubmed
    The murine Nanog gene, a member of the homeobox family of DNA binding transcription factors, has been shown recently to maintain pluripotency of embryonic stem cells...
  17. Hoei Hansen C, Almstrup K, Nielsen J, Brask Sonne S, Graem N, Skakkebaek N, et al. Stem cell pluripotency factor NANOG is expressed in human fetal gonocytes, testicular carcinoma in situ and germ cell tumours. Histopathology. 2005;47:48-56 pubmed
    b>NANOG is a key regulator of embryonic stem cell (ESC) self-renewal and pluripotency...
  18. Kuijk E, de Gier J, Lopes S, Chambers I, van Pelt A, Colenbrander B, et al. A distinct expression pattern in mammalian testes indicates a conserved role for NANOG in spermatogenesis. PLoS ONE. 2010;5:e10987 pubmed publisher
    b>NANOG is a key player in pluripotency and its expression is restricted to pluripotent cells of the inner cell mass, the epiblast and to primordial germ cells...
  19. Lee T, Castilho A, Cheung V, Tang K, Ma S, Ng I. CD24(+) liver tumor-initiating cells drive self-renewal and tumor initiation through STAT3-mediated NANOG regulation. Cell Stem Cell. 2011;9:50-63 pubmed publisher
    ..approach, CD24 was found to be a functional liver T-IC marker that drives T-IC genesis through STAT3-mediated NANOG regulation...
  20. Fareh M, Turchi L, Virolle V, Debruyne D, Almairac F, de la Forest Divonne S, et al. The miR 302-367 cluster drastically affects self-renewal and infiltration properties of glioma-initiating cells through CXCR4 repression and consequent disruption of the SHH-GLI-NANOG network. Cell Death Differ. 2012;19:232-44 pubmed publisher
    ..Furthermore, inhibition of CXCR4 leads to the disruption of the sonic hedgehog (SHH)-GLI-NANOG network, which is involved in self-renewal and expression of the embryonic stem cell-like signature...
  21. Yasuda S, Tsuneyoshi N, Sumi T, Hasegawa K, Tada T, Nakatsuji N, et al. NANOG maintains self-renewal of primate ES cells in the absence of a feeder layer. Genes Cells. 2006;11:1115-23 pubmed
    b>Nanog is a homeodomain transcription factor that is expressed specifically in undifferentiated embryonic stem (ES) cells and has been shown to be essential in the maintenance of pluripotency in mouse ES cells...
  22. Mitsui K, Tokuzawa Y, Itoh H, Segawa K, Murakami M, Takahashi K, et al. The homeoprotein Nanog is required for maintenance of pluripotency in mouse epiblast and ES cells. Cell. 2003;113:631-42 pubmed
    ..We found that one of them, encoding the homeoprotein Nanog, was capable of maintaining ES cell self-renewal independently of LIF/Stat3...
  23. Niu C, Li D, Liu Y, Fu X, Tang S, Li J. Expression of NANOG in human gliomas and its relationship with undifferentiated glioma cells. Oncol Rep. 2011;26:593-601 pubmed publisher
    Stemness genes, including NANOG, which have been reported to play a significant role in embryonic stem cells (ESCs), are purported to be expressed in specific human tumor types...
  24. Kallas A, Pook M, Maimets M, Zimmermann K, Maimets T. Nocodazole treatment decreases expression of pluripotency markers Nanog and Oct4 in human embryonic stem cells. PLoS ONE. 2011;6:e19114 pubmed publisher
    ..Here we report for the first time the changes in the expression of transcription markers Nanog and Oct4 as well as SSEA-3 and SSEA-4 in human embryonic cells after their treatment with nocodazole...
  25. Lin T, Ding Y, Li J. Overexpression of Nanog protein is associated with poor prognosis in gastric adenocarcinoma. Med Oncol. 2012;29:878-85 pubmed publisher
    b>Nanog, a key transcription factor in self-renewal and pluripotency of embryonic stem cells, has been proved to play a novel role in solid tumor development...
  26. Wen J, Park J, Park K, Chung H, Bang S, Park S, et al. Oct4 and Nanog expression is associated with early stages of pancreatic carcinogenesis. Pancreas. 2010;39:622-6 pubmed publisher
    To characterize the role of Oct4 and Nanog, two important homeobox transcription factors of embryonic development, in pancreatic carcinogenesis...
  27. Eberle I, Pless B, Braun M, Dingermann T, Marschalek R. Transcriptional properties of human NANOG1 and NANOG2 in acute leukemic cells. Nucleic Acids Res. 2010;38:5384-95 pubmed publisher
    Transcripts of NANOG and OCT4 have been recently identified in human t(4;11) leukemia and in a model system expressing both t(4;11) fusion proteins...
  28. Ye F, Zhou C, Cheng Q, Shen J, Chen H. Stem-cell-abundant proteins Nanog, Nucleostemin and Musashi1 are highly expressed in malignant cervical epithelial cells. BMC Cancer. 2008;8:108 pubmed publisher
    b>Nanog, nucleostemin (NS) and musashi1 (Msi1) are proteins that are highly expressed in undifferentiated embryonic stem (ES) cells and have been shown to be essential in maintaining the pluripotency and regulating the proliferation and ..
  29. Han J, Mistriotis P, Lei P, Wang D, Liu S, Andreadis S. Nanog reverses the effects of organismal aging on mesenchymal stem cell proliferation and myogenic differentiation potential. Stem Cells. 2012;30:2746-59 pubmed publisher
    ..Here we tested the hypothesis that a single pluripotency-associated transcription factor, namely Nanog, may reverse the proliferation and differentiation potential of bone marrow-derived MSC (BM-MSC) from adult donors...
  30. Ho B, Olson G, Figel S, Gelman I, Cance W, Golubovskaya V. Nanog increases focal adhesion kinase (FAK) promoter activity and expression and directly binds to FAK protein to be phosphorylated. J Biol Chem. 2012;287:18656-73 pubmed publisher
    b>Nanog and FAK were shown to be overexpressed in cancer cells. In this report, the Nanog overexpression increased FAK expression in 293, SW480, and SW620 cancer cells...
  31. Siu M, Wong E, Kong D, Chan H, Jiang L, Wong O, et al. Stem cell transcription factor NANOG controls cell migration and invasion via dysregulation of E-cadherin and FoxJ1 and contributes to adverse clinical outcome in ovarian cancers. Oncogene. 2013;32:3500-9 pubmed publisher
    ..b>NANOG is one of the key transcription factors essential for maintaining self-renewal and pluripotency in stem cells...
  32. Ambady S, Malcuit C, Kashpur O, Kole D, Holmes W, Hedblom E, et al. Expression of NANOG and NANOGP8 in a variety of undifferentiated and differentiated human cells. Int J Dev Biol. 2010;54:1743-54 pubmed publisher
    The transcription factor NANOG is essential for maintaining pluripotency in embryonic stem cells...
  33. Niu C, Yang Y, Cheng C. MiR-134 regulates the proliferation and invasion of glioblastoma cells by reducing Nanog expression. Int J Oncol. 2013;42:1533-40 pubmed publisher
    ..the development of the embryonic stem cell-orientated differentiation to central nervous system by suppression of Nanog and neural development (including neurons, cylindraxile and dendrites) and has been shown to be downregulated in ..
  34. Zhang X, Neganova I, Przyborski S, Yang C, Cooke M, Atkinson S, et al. A role for NANOG in G1 to S transition in human embryonic stem cells through direct binding of CDK6 and CDC25A. J Cell Biol. 2009;184:67-82 pubmed publisher
    In this study, we show that NANOG, a master transcription factor, regulates S-phase entry in human embryonic stem cells (hESCs) via transcriptional regulation of cell cycle regulatory components...
  35. Do H, Lee W, Lim H, Oh J, Kim D, Kim J, et al. Two potent transactivation domains in the C-terminal region of human NANOG mediate transcriptional activation in human embryonic carcinoma cells. J Cell Biochem. 2009;106:1079-89 pubmed publisher
    The core embryonic stem cell transcription factors Oct4, Sox2, and Nanog are expressed in germ cell tumors (GCTs) and have been proposed to play a regulatory role in tumorigenesis...
  36. Hyslop L, Stojkovic M, Armstrong L, Walter T, Stojkovic P, Przyborski S, et al. Downregulation of NANOG induces differentiation of human embryonic stem cells to extraembryonic lineages. Stem Cells. 2005;23:1035-43 pubmed
    The homeobox transcription factor Nanog has been proposed to play a crucial role in the maintenance of the undifferentiated state of murine embryonic stem cells...
  37. Fong H, Hohenstein K, Donovan P. Regulation of self-renewal and pluripotency by Sox2 in human embryonic stem cells. Stem Cells. 2008;26:1931-8 pubmed publisher
    ..Studies in mice have implicated three factors in regulating pluripotency in embryonic stem cells, Oct4, Nanog, and Sox2...
  38. Chang D, Tsai S, Wang X, Xia P, Senadheera D, Lutzko C. Molecular characterization of the human NANOG protein. Stem Cells. 2009;27:812-21 pubmed publisher
    b>NANOG is a key transcriptional regulator of pluripotent stem cell (PSC) self-renewal...
  39. Jeter C, Liu B, Liu X, Chen X, Liu C, Calhoun Davis T, et al. NANOG promotes cancer stem cell characteristics and prostate cancer resistance to androgen deprivation. Oncogene. 2011;30:3833-45 pubmed publisher
    ..recently reported that short-hairpin RNA-mediated knockdown of the embryonic stem cell (ESC) self-renewal gene NANOG significantly reduced the clonogenic and tumorigenic capabilities of various cancer cells...
  40. Matsuoka J, Yashiro M, Sakurai K, Kubo N, Tanaka H, Muguruma K, et al. Role of the stemness factors sox2, oct3/4, and nanog in gastric carcinoma. J Surg Res. 2012;174:130-5 pubmed publisher
    ..Recently, the stemness factors Sox2, Oct3/4, and Nanog were associated with induced pluripotent stem cells, suggesting a correlation between these stemness factors and ..
  41. Hatano S, Tada M, Kimura H, Yamaguchi S, Kono T, Nakano T, et al. Pluripotential competence of cells associated with Nanog activity. Mech Dev. 2005;122:67-79 pubmed publisher
    b>Nanog is a novel pluripotential cell-specific gene that plays a crucial role in maintaining the undifferentiated state of early postimplantation embryos and embryonic stem (ES) cells...
  42. Zhang P, Andrianakos R, Yang Y, Liu C, Lu W. Kruppel-like factor 4 (Klf4) prevents embryonic stem (ES) cell differentiation by regulating Nanog gene expression. J Biol Chem. 2010;285:9180-9 pubmed publisher
    ..In addition, Klf4 directly binds to the promoter region of Nanog and regulates its expression...
  43. Oh J, Do H, Yang H, Moon S, Cha K, Chung H, et al. Identification of a putative transactivation domain in human Nanog. Exp Mol Med. 2005;37:250-4 pubmed
    b>Nanog is a newly identified divergent homeodomain protein that directs the infinite propagation and sustains the pluripotency of embryonic stem cells...
  44. Go M, Takenaka C, Ohgushi H. Forced expression of Sox2 or Nanog in human bone marrow derived mesenchymal stem cells maintains their expansion and differentiation capabilities. Exp Cell Res. 2008;314:1147-54 pubmed publisher
    ..With the aim of conferring higher capability on human bone marrow MSCs, we introduced the Sox2 or Nanog gene into the cells...
  45. Pan Y, Jiao J, Zhou C, Cheng Q, Hu Y, Chen H. Nanog is highly expressed in ovarian serous cystadenocarcinoma and correlated with clinical stage and pathological grade. Pathobiology. 2010;77:283-8 pubmed publisher
    b>Nanog is overexpressed in embryonic stem cells for cell self-renewal and differentiation. We investigated whether the Nanog expression is associated with the occurrence and development of ovarian cancer...
  46. Guo Y, Liu S, Wang P, Zhao S, Wang F, Bing L, et al. Expression profile of embryonic stem cell-associated genes Oct4, Sox2 and Nanog in human gliomas. Histopathology. 2011;59:763-75 pubmed publisher
    To investigate whether Oct4, Sox2 and Nanog, three core regulatory factors maintaining pluripotency and self-renewal of embryonic stem cells (ESCs), are coexpressed in human gliomas, and whether their expression might be linked to ..
  47. Ramakrishna S, Suresh B, Lim K, Cha B, Lee S, Kim K, et al. PEST motif sequence regulating human NANOG for proteasomal degradation. Stem Cells Dev. 2011;20:1511-9 pubmed publisher
    A number of transcriptional factors are required for pluripotency of stem cells. NANOG, a homeobox transcription factor, plays a critical role in regulating embryonic stem cell (ESC) pluripotency...
  48. Jeter C, Badeaux M, Choy G, Chandra D, Patrawala L, Liu C, et al. Functional evidence that the self-renewal gene NANOG regulates human tumor development. Stem Cells. 2009;27:993-1005 pubmed publisher
    ..The embryonic stem cell (ESC) self-renewal gene NANOG is purportedly expressed by some epithelial cancer cells but a causal role in tumor development has remained ..
  49. Po A, Ferretti E, Miele E, De Smaele E, Paganelli A, Canettieri G, et al. Hedgehog controls neural stem cells through p53-independent regulation of Nanog. EMBO J. 2010;29:2646-58 pubmed publisher
    ..The transcription factor Nanog controls stemness acting as a key determinant of both embryonic SC self-renewal and differentiated somatic cells ..
  50. Yang L, Zhang X, Zhang M, Zhang J, Sheng Y, Sun X, et al. Increased Nanog expression promotes tumor development and Cisplatin resistance in human esophageal cancer cells. Cell Physiol Biochem. 2012;30:943-52 pubmed publisher
    b>Nanog plays a key role in stem cell self-renewal and pluripotency differentiation in embryonic stem cells ( ESCs)...
  51. Moon J, Kwon S, Jun E, Kim A, Whang K, Kim H, et al. Nanog-induced dedifferentiation of p53-deficient mouse astrocytes into brain cancer stem-like cells. Biochem Biophys Res Commun. 2011;412:175-81 pubmed publisher
    ..Here, we report a role of Nanog in the genesis of cancer stem-like cells...
  52. Darr H, Mayshar Y, Benvenisty N. Overexpression of NANOG in human ES cells enables feeder-free growth while inducing primitive ectoderm features. Development. 2006;133:1193-201 pubmed
    ..Recently, the transcription factor Nanog was suggested to allow LIF and feeder-free growth of MESCs...
  53. Du Y, Shi L, Wang T, Liu Z, Wang Z. Nanog siRNA plus Cisplatin may enhance the sensitivity of chemotherapy in esophageal cancer. J Cancer Res Clin Oncol. 2012;138:1759-67 pubmed
    Cancer stem cells are regarded as the origin of tumors that can proliferate, relapse, and metastasize. Nanog, with its capacity to maintain the pluripotency and regulate proliferation and prevent differentiation, is one of the most ..
  54. Tsai C, Su P, Huang Y, Yew T, Hung S. Oct4 and Nanog directly regulate Dnmt1 to maintain self-renewal and undifferentiated state in mesenchymal stem cells. Mol Cell. 2012;47:169-82 pubmed publisher
    The roles of Oct4 and Nanog in maintaining self-renewal and undifferentiated status of adult stem cells are unclear...
  55. Liu T, Wu Y, Guo X, Hui J, Lee E, Lim B. Effects of ectopic Nanog and Oct4 overexpression on mesenchymal stem cells. Stem Cells Dev. 2009;18:1013-22 pubmed publisher
    ..b>Nanog and Oct4 are key transcription factors essential to the pluripotent and self-renewing phenotypes of ..
  56. Kohler E, Cowan C, Chatterjee I, Malik A, Wary K. NANOG induction of fetal liver kinase-1 (FLK1) transcription regulates endothelial cell proliferation and angiogenesis. Blood. 2011;117:1761-9 pubmed publisher
    b>NANOG is a master transcription factor associated with the maintenance of stem cell pluripotency. Here, we demonstrate that transcription factor NANOG is expressed in cultured endothelial cells (ECs) and in a subset of tumor cell lines...
  57. Kim J, Kim J, Kim B, Chung H, Lee Y, Park C, et al. Identification and functional characterization of an alternative splice variant within the fourth exon of human nanog. Exp Mol Med. 2005;37:601-7 pubmed
    b>Nanog, a homeodomain (HD) transcription factor, plays a critical role in the maintenance of embryonic stem (ES) cell self-renewal. Here, we report the identification of an alternatively-spliced variant of nanog...
  58. Savarese F, Davila A, Nechanitzky R, De La Rosa Velazquez I, Pereira C, Engelke R, et al. Satb1 and Satb2 regulate embryonic stem cell differentiation and Nanog expression. Genes Dev. 2009;23:2625-38 pubmed publisher
    ..cells display an impaired differentiation potential and augmented expression of the pluripotency determinants Nanog, Klf4, and Tbx3...
  59. Zaehres H, Lensch M, Daheron L, Stewart S, Itskovitz Eldor J, Daley G. High-efficiency RNA interference in human embryonic stem cells. Stem Cells. 2005;23:299-305 pubmed
    ..of a green fluorescent protein (GFP) trans gene and the stem cell-specific transcription factors Oct4/POU5F1 and Nanog in human embryonic stem cells...
  60. Do H, Lim H, Kim J, Song H, Chung H, Kim J. An intact homeobox domain is required for complete nuclear localization of human Nanog. Biochem Biophys Res Commun. 2007;353:770-5 pubmed
    b>Nanog is a homeobox-containing transcriptional factor required for maintaining the pluripotent state of stem cells. We investigated the nuclear localization signal (NLS) motif required for human Nanog (hNanog) nuclear import...
  61. Piestun D, Kochupurakkal B, Jacob Hirsch J, Zeligson S, Koudritsky M, Domany E, et al. Nanog transforms NIH3T3 cells and targets cell-type restricted genes. Biochem Biophys Res Commun. 2006;343:279-85 pubmed
    The transcription factor Nanog is uniquely expressed in embryonic stem (ES) cells and in germ cell tumors and is important for self-renewal...
  62. Gu T, Liu S, Zheng P. Cytoplasmic NANOG-positive stromal cells promote human cervical cancer progression. Am J Pathol. 2012;181:652-61 pubmed publisher
    Tumor development has long been known to resemble abnormal embryogenesis. The embryonic stem cell gene NANOG, a divergent homeodomain transcription factor that is independent of leukemia inhibitory factor, has been reported to be ..
  63. Chiou S, Yu C, Huang C, Lin S, Liu C, Tsai T, et al. Positive correlations of Oct-4 and Nanog in oral cancer stem-like cells and high-grade oral squamous cell carcinoma. Clin Cancer Res. 2008;14:4085-95 pubmed publisher
    ..Enriched OC-SLC highly expressed the stem/progenitor cell markers and ABC transporter gene (Oct-4, Nanog, CD117, Nestin, CD133, and ABCG2) and also displayed induced differentiation abilities and enhanced migration/..
  64. Bourguignon L, Peyrollier K, Xia W, Gilad E. Hyaluronan-CD44 interaction activates stem cell marker Nanog, Stat-3-mediated MDR1 gene expression, and ankyrin-regulated multidrug efflux in breast and ovarian tumor cells. J Biol Chem. 2008;283:17635-51 pubmed publisher
    ..In this study we investigated HA-induced interaction between CD44 (a HA receptor) and Nanog (an embryonic stem cell transcription factor) in both human breast tumor cells (MCF-7 cells) and human ovarian ..
  65. Clark A, Rodriguez R, Bodnar M, Abeyta M, Cedars M, Turek P, et al. Human STELLAR, NANOG, and GDF3 genes are expressed in pluripotent cells and map to chromosome 12p13, a hotspot for teratocarcinoma. Stem Cells. 2004;22:169-79 pubmed
    ..to a previously uncharacterized homeobox gene, which is the human homolog of the recently identified murine gene, Nanog, and proximal to the GDF3 locus, whose transcription is restricted to germ cell tumor cells...
  66. Moretto Zita M, Jin H, Shen Z, Zhao T, Briggs S, Xu Y. Phosphorylation stabilizes Nanog by promoting its interaction with Pin1. Proc Natl Acad Sci U S A. 2010;107:13312-7 pubmed publisher
    ..The mechanisms that maintain self-renewal of ESCs remain unclear. Here we show that Nanog, a transcription factor crucial for the self-renewal of ESCs, is phosphorylated at multiple Ser/Thr-Pro motifs...