MSC

Summary

Gene Symbol: MSC
Description: musculin
Alias: ABF-1, ABF1, MYOR, bHLHa22, musculin, activated B-cell factor 1, homolog of mouse musculin, activated B-cell factor-1, class A basic helix-loop-helix protein 22
Species: human
Products:     MSC

Top Publications

  1. He X, Wang X, Fang J, Chang Y, Ning N, Guo H, et al. The genus Achyranthes: A review on traditional uses, phytochemistry, and pharmacological activities. J Ethnopharmacol. 2017;203:260-278 pubmed publisher
    ..also obtained from International Plant Names Index, Chinese Pharmacopoeia, Chinese herbal classic books, PhD and MSc dissertations, etc...
  2. Anyanwu G, Nisar ur Rehman -, Onyeneke C, Rauf K. Medicinal plants of the genus Anthocleista--A review of their ethnobotany, phytochemistry and pharmacology. J Ethnopharmacol. 2015;175:648-67 pubmed publisher
    ..Scopus, PubChem and other web sources such as The Plant List, Kew Botanical Garden and PROTA) and books, PhD and MSc dissertations for un-published resources...
  3. Zhang L, Li Y, Guan C, Tian S, Lv X, Li J, et al. Therapeutic effect of human umbilical cord-derived mesenchymal stem cells on injured rat endometrium during its chronic phase. Stem Cell Res Ther. 2018;9:36 pubmed publisher
    ..The cell proliferation marker Ki-67 had a positive expression in the injured endometrium after UC-MSC transplantation...
  4. Manzini B, da Silva Santos Duarte A, Sankaramanivel S, Ramos A, Latuf Filho P, Escanhoela C, et al. Useful properties of undifferentiated mesenchymal stromal cells and adipose tissue as the source in liver-regenerative therapy studied in an animal model of severe acute fulminant hepatitis. Cytotherapy. 2015;17:1052-65 pubmed publisher
    ..This study aimed to analyze whether undifferentiated mesenchymal stromal cells (U-MSCs) or MSC-derived hepatocyte-like cells (DHLCs) from adipose tissue (AT), umbilical cord blood (UCB) and bone marrow (BM) ..
  5. He X, Bai Y, Zhao Z, Wang X, Fang J, Huang L, et al. Local and traditional uses, phytochemistry, and pharmacology of Sophora japonica L.: A review. J Ethnopharmacol. 2016;187:160-82 pubmed publisher
    ..was also obtained from local classic herbal literature, government reports, conference papers, as well as PhD and MSc dissertations...
  6. Liu S, Tang Z, Liao Z, Cui C, Liu H, Liang Y, et al. The chemistry and pharmacology of Ligularia przewalskii: A review. J Ethnopharmacol. 2018;219:32-49 pubmed publisher
    ..The information on LP will be helpful in providing and identifying its therapeutic potential and economic value for its use as a new medicine in the future. ..
  7. Souza M, Silva J, Pádua T, Torres N, Antunes M, Xisto D, et al. Mesenchymal stromal cell therapy attenuated lung and kidney injury but not brain damage in experimental cerebral malaria. Stem Cell Res Ther. 2015;6:102 pubmed publisher
    ..Mesenchymal stromal cells (MSC) confer host resistance against malaria; however, thus far, no study has evaluated the therapeutic effects of MSC ..
  8. Peng W, Liu Y, Wu N, Sun T, He X, Gao Y, et al. Areca catechu L. (Arecaceae): a review of its traditional uses, botany, phytochemistry, pharmacology and toxicology. J Ethnopharmacol. 2015;164:340-56 pubmed publisher
    ..A literature search was performed on A. catechu based on classic books of herbal medicine, PhD. and MSc. dissertations, government reports, the state and local drug standards, scientific databases including Pubmed, ..
  9. Sala E, Genua M, Petti L, Anselmo A, Arena V, Cibella J, et al. Mesenchymal Stem Cells Reduce Colitis in Mice via Release of TSG6, Independently of Their Localization to the Intestine. Gastroenterology. 2015;149:163-176.e20 pubmed publisher
    ..MSCs were reported to reduce colitis in mice; we investigated whether MSC localization to the intestine and production of paracrine factors, including tumor necrosis factor-induced protein ..

More Information

Publications152 found, 100 shown here

  1. Guo Y, Yin T, Wang X, Zhang F, Pan G, Lv H, et al. Traditional uses, phytochemistry, pharmacology and toxicology of the genus Cimicifuga: A review. J Ethnopharmacol. 2017;209:264-282 pubmed publisher
    ..of Science, China Knowledge Resource Integrated Database), Chinese herbal classics, ethnobotanical books, PhD and MSc dissertations, Chinese Pharmacopoeia, published articles in peer-reviewed journals, local magazines, and ..
  2. He X, Fang J, Huang L, Wang J, Huang X. Sophora flavescens Ait.: Traditional usage, phytochemistry and pharmacology of an important traditional Chinese medicine. J Ethnopharmacol. 2015;172:10-29 pubmed publisher
    ..was also acquired from local classic herbal literature, conference papers, government reports, and PhD and MSc dissertations...
  3. Bian P, Ye C, Zheng X, Yang J, Ye W, Wang Y, et al. Mesenchymal stem cells alleviate Japanese encephalitis virus-induced neuroinflammation and mortality. Stem Cell Res Ther. 2017;8:38 pubmed publisher
    ..b>MSC treatment reduced JEV-induced mortality and improved the recovery from JE in our mouse model...
  4. Tyndall A, van Laar J. Stem cell transplantation and mesenchymal cells to treat autoimmune diseases. Presse Med. 2016;45:e159-69 pubmed publisher
    ..Mesenchymal stromal cells (MSC), often incorrectly called stem cells, have been the intense focus of in vitro studies and animal models of ..
  5. An S, Jang Y, Lim H, Han J, Lee J, Lee G, et al. Milk Fat Globule-EGF Factor 8, Secreted by Mesenchymal Stem Cells, Protects Against Liver Fibrosis in Mice. Gastroenterology. 2017;152:1174-1186 pubmed publisher
    ..We analyzed the effects of MSC secretomes and potential anti-fibrotic proteins on transforming growth factor β 1 (TGFβ1)-mediated activation ..
  6. Levato R, Webb W, Otto I, Mensinga A, Zhang Y, van Rijen M, et al. The bio in the ink: cartilage regeneration with bioprintable hydrogels and articular cartilage-derived progenitor cells. Acta Biomater. 2017;61:41-53 pubmed publisher
    ..By combining ACPC- and MSC-laden bioinks, a bioprinted model of articular cartilage was generated, consisting of defined superficial and deep ..
  7. Yang W, Zheng H, Wang Y, Lian F, Hu Z, Xue S. Nesprin-1 has key roles in the process of mesenchymal stem cell differentiation into cardiomyocyte-like cells in vivo and in vitro. Mol Med Rep. 2015;11:133-42 pubmed publisher
    ..Surface-associated antigens of MSCs were detected by flow cytometry. MSC differentiation was induced by treatment with 10 µmol/l 5-azacytidine...
  8. Zhu A, Zhang T, Wang Q. The phytochemistry, pharmacokinetics, pharmacology and toxicity of Euphorbia semen. J Ethnopharmacol. 2018;: pubmed publisher
    ..In this manuscript, a number of books, PhD and MSc dissertations, and Chinese Pharmacopeia were also used as references...
  9. Zhu B, Zhang Q, Hua J, Cheng W, Qin L. The traditional uses, phytochemistry, and pharmacology of Atractylodes macrocephala Koidz.: A review. J Ethnopharmacol. 2018;226:143-167 pubmed publisher
    ..Further research on the comprehensive evaluation of medicinal quality, the understanding of multi-target network pharmacology of A. macrocephala, as well as its long-term in vivo toxicity and clinical efficacy is recommended. ..
  10. Xu L, Wang S, Wang D, Ma L, Chen Z, Chen Q, et al. Adipose-derived stromal cells resemble bone marrow stromal cells in hepatocyte differentiation potential in vitro and in vivo. World J Gastroenterol. 2017;23:6973-6982 pubmed publisher
    ..There was no significant difference between the two MSC groups...
  11. Du T, Cheng J, Zhong L, Zhao X, Zhu J, Zhu Y, et al. The alleviation of acute and chronic kidney injury by human Wharton's jelly-derived mesenchymal stromal cells triggered by ischemia-reperfusion injury via an endocrine mechanism. Cytotherapy. 2012;14:1215-27 pubmed publisher
    The effects of human Wharton's jelly-derived mesenchymal stromal cells (WJ-MSC) on acute and chronic kidney injury induced by ischemia-reperfusion injury (IRI) were assessed...
  12. Nong K, Wang W, Niu X, Hu B, Ma C, Bai Y, et al. Hepatoprotective effect of exosomes from human-induced pluripotent stem cell-derived mesenchymal stromal cells against hepatic ischemia-reperfusion injury in rats. Cytotherapy. 2016;18:1548-1559 pubmed publisher
    ..hiPSCs were efficiently induced into hiPSC-MSCs with typical MSC characteristics...
  13. Chen H, Xiang H, Xu W, Li M, Yuan J, Liu J, et al. Manganese Superoxide Dismutase Gene-Modified Mesenchymal Stem Cells Attenuate Acute Radiation-Induced Lung Injury. Hum Gene Ther. 2017;28:523-532 pubmed publisher
    ..factor transforming growth factor-?1, and the oxidative stress factor (hydroxyproline) were evaluated after MnSOD-MSC transplant...
  14. Sir G, Goker Bagca B, Yigitturk G, Cavusoğlu T, Biray Avci C, Gunduz C, et al. Antagonistic Effect of Oxytocin and Tacrolimus Combination on Adipose Tissue - Derived Mesenchymal Stem Cells: Antagonistic effect of oxytocin and tacrolimus. Biomed Pharmacother. 2018;97:1173-1181 pubmed publisher
    ..cytotoxic, apoptotic and morphological effects of FK506, an immunosuppressive agent, on adipose tissue - derived MSC (ADMSC) which has the potential to be used for immune suppression...
  15. Guo D, Zhu X, Li Q, Liu G, Ruan G, Pang R, et al. Efficacy and mechanisms underlying the effects of allogeneic umbilical cord mesenchymal stem cell transplantation on acute radiation injury in tree shrews. Cytotechnology. 2018;: pubmed publisher
    ..IL-8 and the fibrosis-related factors PDGF-BB, PDGF-AA, TGF-?1, IGFBP-2, and IGFBP-4 were significantly lower in UC-MSC-injected animals...
  16. Wang L, Yu Y, Guan H, Qiao C. Effect of Human Umbilical Cord Mesenchymal Stem Cell Transplantation in a Rat Model of Preeclampsia. Reprod Sci. 2016;23:1058-70 pubmed publisher
    To test the effects of human umbilical cord mesenchymal stem cell (HU-MSC) transplantation on reversing preeclampsia (PE) symptoms in a lipopolysaccharide (LPS)-induced rat PE model...
  17. Park H, Shin J, Kim H, Oh S, Song S, Lee P. Mesenchymal stem cells stabilize the blood-brain barrier through regulation of astrocytes. Stem Cell Res Ther. 2015;6:187 pubmed publisher
    ..In the present study, we investigated whether mesenchymal stem cell (MSC) treatment might modulate reactive astrocytes and thus stabilize BBB integrity through vascular endothelial growth ..
  18. He X, Wang X, Fang J, Zhao Z, Huang L, Guo H, et al. Bletilla striata: Medicinal uses, phytochemistry and pharmacological activities. J Ethnopharmacol. 2017;195:20-38 pubmed publisher
    ..Information was also obtained from The Plant List, Chinese pharmacopoeia, Chinese herbal classics books, PhD and MSc dissertations, etc...
  19. Lu F, Wang F, Chen Z, Huang H. Effect of mesenchymal stem cells on small intestinal injury in a rat model of acute necrotizing pancreatitis. Stem Cell Res Ther. 2017;8:12 pubmed publisher
    ..In conclusion, MSC therapy could alleviate small intestinal injury in rats with ANP, the mechanism of which might be related to ..
  20. Saito A, Ooki A, Nakamura T, Onodera S, Hayashi K, Hasegawa D, et al. Targeted reversion of induced pluripotent stem cells from patients with human cleidocranial dysplasia improves bone regeneration in a rat calvarial bone defect model. Stem Cell Res Ther. 2018;9:12 pubmed publisher
    ..At present, as a therapeutic strategy for osteoporosis, mesenchymal stem cell (MSC) transplantation therapy is performed in addition to drug therapy...
  21. Li J, Dai Y, Zhu H, Jiang Y, Zhang S. Endometriotic mesenchymal stem cells significantly promote fibrogenesis in ovarian endometrioma through the Wnt/β-catenin pathway by paracrine production of TGF-β1 and Wnt1. Hum Reprod. 2016;31:1224-35 pubmed publisher
    ..Additionally, fibrogenic effects of Ecto-MSC CM treatment on endometriotic implants were analyzed using a xenograft model of endometriosis in immunodeficient ..
  22. Chadid T, Morris A, Surowiec A, Robinson S, Sasaki M, Galipeau J, et al. Reversible secretome and signaling defects in diabetic mesenchymal stem cells from peripheral arterial disease patients. J Vasc Surg. 2018;: pubmed publisher
    ..Both BM- and ATD-dMSCs had typical MSC surface marker expression and similar expansion profiles, and they did not express EGF in their secretome...
  23. Yan X, Cen Y, Wang Q. Mesenchymal stem cells alleviate experimental rheumatoid arthritis through microRNA-regulated I?B expression. Sci Rep. 2016;6:28915 pubmed publisher
    Previous studies have demonstrated that mesenchymal stem cell (MSC) transplantation reduces the severity of collagen-induced arthritis (CIA) in mice, which is a model for rheumatoid arthritis (RA) in humans...
  24. Gómez Mauricio G, Moscoso I, Martín Cancho M, Crisostomo V, Prat Vidal C, Báez Díaz C, et al. Combined administration of mesenchymal stem cells overexpressing IGF-1 and HGF enhances neovascularization but moderately improves cardiac regeneration in a porcine model. Stem Cell Res Ther. 2016;7:94 pubmed publisher
    ..Here, we evaluated the combination of cell- and gene-based therapy using mesenchymal stem cells (MSC) genetically modified to overexpress IGF-1 or HGF to treat acute myocardial infarction (AMI) in a porcine model...
  25. Suzuki K, Chosa N, Sawada S, Takizawa N, Yaegashi T, Ishisaki A. Enhancement of Anti-Inflammatory and Osteogenic Abilities of Mesenchymal Stem Cells via Cell-to-Cell Adhesion to Periodontal Ligament-Derived Fibroblasts. Stem Cells Int. 2017;2017:3296498 pubmed publisher
    ..In addition, the direct-contact coculture enhanced the expression of MSC markers that play important roles in the self-renewal and maintenance of multipotency of MSCs, which in turn ..
  26. Stavenschi E, Labour M, Hoey D. Oscillatory fluid flow induces the osteogenic lineage commitment of mesenchymal stem cells: The effect of shear stress magnitude, frequency, and duration. J Biomech. 2017;55:99-106 pubmed publisher
    ..marrow cavity is sufficient to directly drive the osteogenic lineage commitment of resident mesenchymal stem cells (MSC)...
  27. Tamaki S, Fukuta M, Sekiguchi K, Jin Y, Nagata S, Hayakawa K, et al. SS18-SSX, the Oncogenic Fusion Protein in Synovial Sarcoma, Is a Cellular Context-Dependent Epigenetic Modifier. PLoS ONE. 2015;10:e0142991 pubmed publisher
    ..of FZD10, identified as an SS-specific gene, was induced by SS18-SSX at the PSC and NCC stages, but not at the MSC stage...
  28. Korang Yeboah M, Rahman Z, Shah D, Khan M. Spectroscopic-Based Chemometric Models for Quantifying Low Levels of Solid-State Transitions in Extended Release Theophylline Formulations. J Pharm Sci. 2016;105:97-105 pubmed publisher
    ..The model diagnostic statistics were similar for MSC-SG and SNV-SG treated spectra. Similarly, PLSR and PCR models had comparable performance...
  29. Herzmann N, Salamon A, Fiedler T, Peters K. Analysis of migration rate and chemotaxis of human adipose-derived mesenchymal stem cells in response to LPS and LTA in vitro. Exp Cell Res. 2016;342:95-103 pubmed publisher
    Mesenchymal stem cells (MSC) are able to stimulate the regeneration of injured tissue. Since bacterial infections are common complications in wound healing, bacterial pathogens and their components come into direct contact with MSC...
  30. Shi W, Huang C, Xu X, Jin G, Huang R, Huang J, et al. Transplantation of RADA16-BDNF peptide scaffold with human umbilical cord mesenchymal stem cells forced with CXCR4 and activated astrocytes for repair of traumatic brain injury. Acta Biomater. 2016;45:247-261 pubmed publisher
    ..from hUC-MSCs in vitro and in vivo, indicating the 3D R-B-SPH scaffold provided a suitable microenvironment for hUC-MSC survival, proliferation and differentiation...
  31. Ma H, Shi X, Yuan X, Ding Y.  IL-1β siRNA adenovirus benefits liver regeneration by improving mesenchymal stem cells survival after acute liver failure. Ann Hepatol. 2016;15:260-70 pubmed publisher
    ..To assess the effect of IL-1? siRNA adenovirus on MSC and the therapeutic effect of MSC combined with IL-1? siRNA adenovirus in ALF...
  32. Deng P, Zhou C, Alvarez R, Hong C, Wang C. Inhibition of IKK/NF-κB Signaling Enhances Differentiation of Mesenchymal Stromal Cells from Human Embryonic Stem Cells. Stem Cell Reports. 2016;6:456-465 pubmed publisher
    ..differentiation of hESCs into MSCs by expediting the loss of pluripotent markers and increasing the expression of MSC surface markers...
  33. Matsui F, Babitz S, Rhee A, Hile K, Zhang H, Meldrum K. Mesenchymal stem cells protect against obstruction-induced renal fibrosis by decreasing STAT3 activation and STAT3-dependent MMP-9 production. Am J Physiol Renal Physiol. 2017;312:F25-F32 pubmed publisher
    STAT3 is a transcription factor implicated in renal fibrotic injury, but the role of STAT3 in mesenchymal stem cell (MSC)-induced renoprotection during renal fibrosis remains unknown...
  34. Han N, Zhang F, Li G, Zhang X, Lin X, Yang H, et al. Local application of IGFBP5 protein enhanced periodontal tissue regeneration via increasing the migration, cell proliferation and osteo/dentinogenic differentiation of mesenchymal stem cells in an inflammatory niche. Stem Cell Res Ther. 2017;8:210 pubmed publisher
    ..The number of mesenchymal stem cells (MSCs) in patients with periodontitis is decreased, and MSC functions are impaired...
  35. Jain L, Panda K, Basu S. Clinical Outcomes of Adjunctive Sustained-Release Intravitreal Dexamethasone Implants in Tuberculosis-Associated Multifocal Serpigenoid Choroiditis. Ocul Immunol Inflamm. 2017;:1-7 pubmed publisher
    To analyze the safety and efficacy of sustained-release intravitreal dexamethasone implant (Ozurdex) in management of TB-associated multifocal serpiginoid choroiditis (MSC).
  36. Rajendran R, Gangadaran P, Bak S, Oh J, Kalimuthu S, Lee H, et al. Extracellular vesicles derived from MSCs activates dermal papilla cell in vitro and promotes hair follicle conversion from telogen to anagen in mice. Sci Rep. 2017;7:15560 pubmed publisher
    ..papilla (DP) cells in the presence or absence of treatment with mesenchymal stem cell extracellular vesicles (MSC-EVs). In addition, we tested the efficacy of MSC-EV treatment on hair growth in an animal model...
  37. Ke C, Biao H, Qianqian L, Yunwei S, Xiaohua J. Mesenchymal stem cell therapy for inflammatory bowel diseases: promise and challenge. Curr Stem Cell Res Ther. 2015;10:499-508 pubmed
    ..We justify the use of MSC-based cell therapy as a novel strategy for IBD, discuss the biological roles that MSCs play underlying their ..
  38. Caplan A, Hariri R. Body Management: Mesenchymal Stem Cells Control the Internal Regenerator. Stem Cells Transl Med. 2015;4:695-701 pubmed publisher
    ..The multipotent mesenchymal stem cell (MSC), now renamed the medicinal signaling cell, predominantly arises from pericytes released from broken and inflamed ..
  39. Montali M, Barachini S, Pacini S, Panvini F, Petrini M. Isolating Mesangiogenic Progenitor Cells (MPCs) from Human Bone Marrow. J Vis Exp. 2016;: pubmed publisher
    ..This is as also suggested by Ki-67 negativity. On the other hand, culturing MPCs in standard medium designed for MSC expansion, gave rise to a population of exponentially growing MSC-like cells...
  40. Ern C, Berger T, Frasheri I, Heym R, Hickel R, Folwaczny M. Differentiation of hMSC and hPDLSC induced by PGE2 or BMP-7 in 3D models. Prostaglandins Leukot Essent Fatty Acids. 2017;122:30-37 pubmed publisher
    ..In conclusion, BMP7, in particular combined with MSC, seems to have a favourable application also in periodontal regeneration...
  41. Pernal S, Wu V, Uskoković V. Hydroxyapatite as a Vehicle for the Selective Effect of Superparamagnetic Iron Oxide Nanoparticles against Human Glioblastoma Cells. ACS Appl Mater Interfaces. 2017;9:39283-39302 pubmed publisher
    ..between the two components of the nanocomposites was established; as a result, the cancer versus healthy cell (U87/MSC) selectivity in terms of both the uptake and the toxicity was higher for the composite than for SPIONs or HAP alone,..
  42. Kang R, Zhou Y, Tan S, Zhou G, Aagaard L, Xie L, et al. Mesenchymal stem cells derived from human induced pluripotent stem cells retain adequate osteogenicity and chondrogenicity but less adipogenicity. Stem Cell Res Ther. 2015;6:144 pubmed publisher
    ..Two iPSC-MSC lines (named as mRNA-iPSC-MSC-YL001 and lenti-iPSC-MSC-A001) and one BM-MSC line were used for the study...
  43. Sung D, Chang Y, Ahn S, Sung S, Yoo H, Choi S, et al. Optimal Route for Human Umbilical Cord Blood-Derived Mesenchymal Stem Cell Transplantation to Protect Against Neonatal Hyperoxic Lung Injury: Gene Expression Profiles and Histopathology. PLoS ONE. 2015;10:e0135574 pubmed publisher
    The aim of this study was to determine the optimal route of mesenchymal stem cell (MSC) transplantation. To this end, gene expression profiling was performed to compare the effects of intratracheal (i.t.) versus intravenous (i.v...
  44. Neirinckx V, Agirman G, Coste C, Marquet A, Dion V, Rogister B, et al. Adult bone marrow mesenchymal and neural crest stem cells are chemoattractive and accelerate motor recovery in a mouse model of spinal cord injury. Stem Cell Res Ther. 2015;6:211 pubmed publisher
    ..Finally, it appears that MSC injection in the spinal cord enhance early inflammatory events in the blood and spinal cord of SCI mice...
  45. Kondo S, Muneta T, Nakagawa Y, Koga H, Watanabe T, Tsuji K, et al. Transplantation of autologous synovial mesenchymal stem cells promotes meniscus regeneration in aged primates. J Orthop Res. 2017;35:1274-1282 pubmed publisher
    ..meniscus was larger and the modified Pauli's histological score for the regenerated meniscus was better in the MSC group than in the control group in each primate at 8 and 16 weeks...
  46. Hu X, Chen P, Wu Y, Wang K, Xu Y, Chen H, et al. MiR-211/STAT5A Signaling Modulates Migration of Mesenchymal Stem Cells to Improve its Therapeutic Efficacy. Stem Cells. 2016;34:1846-58 pubmed publisher
    ..This study was designed to investigate a possible role for miR-211 in MSC migration, and whether genetic manipulation of miR-211 in MSCs could be used to enhance its beneficial effects of ..
  47. Skog M, Nystedt J, Korhonen M, Anderson H, Lehti T, Pajunen M, et al. Expression of neural cell adhesion molecule and polysialic acid in human bone marrow-derived mesenchymal stromal cells. Stem Cell Res Ther. 2016;7:113 pubmed publisher
    ..We have studied NCAM and polySia expression in five hBM-MSC lines at mRNA and protein levels...
  48. Low W, Rujitanaroj P, Lee D, Kuang J, Messersmith P, Chan J, et al. Mussel-Inspired Modification of Nanofibers for REST siRNA Delivery: Understanding the Effects of Gene-Silencing and Substrate Topography on Human Mesenchymal Stem Cell Neuronal Commitment. Macromol Biosci. 2015;15:1457-68 pubmed publisher
    ..Under non-specific differentiation condition, REST silencing and fiber topography enhanced MSC neuronal markers expressions and reduced glial cell commitment...
  49. Lu S, Lee E, Lam J, Tabata Y, Mikos A. Evaluation of Gelatin Microparticles as Adherent-Substrates for Mesenchymal Stem Cells in a Hydrogel Composite. Ann Biomed Eng. 2016;44:1894-907 pubmed publisher
    ..MSCs were seeded onto GMPs of varying crosslinking densities and sizes to investigate their role on influencing MSC differentiation and aggregation...
  50. Zhang C, Lim J, Liu J, Ponugoti B, Alsadun S, Tian C, et al. FOXO1 expression in keratinocytes promotes connective tissue healing. Sci Rep. 2017;7:42834 pubmed publisher
    ..formation of new connective tissue, which requires the generation of signals that stimulate mesenchymal stem cells (MSC), myofibroblasts and fibroblasts. A key role for keratinocytes in this complex process has yet to be established...
  51. Sueyama Y, Kaneko T, Ito T, Kaneko R, Okiji T. Implantation of Endothelial Cells with Mesenchymal Stem Cells Accelerates Dental Pulp Tissue Regeneration/Healing in Pulpotomized Rat Molars. J Endod. 2017;43:943-948 pubmed publisher
    ..Bcl-2, Cxcl1, Cxcr2, and Dspp messenger RNA levels were significantly up-regulated in the pulp of MSC/EC-implanted teeth compared with those in MSC-implanted teeth...
  52. Shao D, Lu M, Xu D, Zheng X, Pan Y, Song Y, et al. Carbon dots for tracking and promoting the osteogenic differentiation of mesenchymal stem cells. Biomater Sci. 2017;5:1820-1827 pubmed publisher
    ..highly desirable to develop biocompatible nanomaterials to integrate cell fate regulation with monitoring for MSC-based therapy...
  53. Wilson K, Jagger A, Walker M, Seinkmane E, Fox J, Kröger R, et al. Glycans modify mesenchymal stem cell differentiation to impact on the function of resulting osteoblasts. J Cell Sci. 2018;131: pubmed publisher
    ..By using an immortalized human mesenchymal stromal cell (MSC) line model, we show that both N- and O-glycan processing in the Golgi functionally modulates early steps of ..
  54. Suresh S, Selvaraju V, Thirunavukkarasu M, Goldman J, Husain A, Alexander Palesty J, et al. Thioredoxin-1 (Trx1) engineered mesenchymal stem cell therapy increased pro-angiogenic factors, reduced fibrosis and improved heart function in the infarcted rat myocardium. Int J Cardiol. 2015;201:517-28 pubmed publisher
    ..Rat MSCs were cultured and divided into MSC, MSC+Ad.LacZ, and MSC+Ad.Trx1 groups. The cells were assayed for proliferation, and differentiation potential...
  55. Peffers M, Collins J, Fang Y, Goljanek Whysall K, Rushton M, Loughlin J, et al. Age-related changes in mesenchymal stem cells identified using a multi-omics approach. Eur Cell Mater. 2016;31:136-59 pubmed
    Mesenchymal stem cells (MSC) are capable of multipotent differentiation into connective tissues and as such are an attractive source for autologous cell-based treatments for many clinical diseases and injuries...
  56. Irianto J, Xia Y, Pfeifer C, Athirasala A, Ji J, Alvey C, et al. DNA Damage Follows Repair Factor Depletion and Portends Genome Variation in Cancer Cells after Pore Migration. Curr Biol. 2017;27:210-223 pubmed publisher
    ..from constricted migration of U2OS clones are further illustrated by a clone with a highly elongated and stable MSC-like shape that depends on microtubule assembly downstream of the transcription factor GATA4...
  57. Baglio S, Lagerweij T, Pérez Lanzón M, Ho X, Léveillé N, Melo S, et al. Blocking Tumor-Educated MSC Paracrine Activity Halts Osteosarcoma Progression. Clin Cancer Res. 2017;23:3721-3733 pubmed publisher
    ..Characterization and functional studies were designed to assess the mechanisms underlying MSC education...
  58. Gonzalez King H, García N, Ontoria Oviedo I, Ciria M, Montero J, Sepúlveda P. Hypoxia Inducible Factor-1α Potentiates Jagged 1-Mediated Angiogenesis by Mesenchymal Stem Cell-Derived Exosomes. Stem Cells. 2017;35:1747-1759 pubmed publisher
    ..Here, we studied the contribution of exosomes released by HIF-1α-overexpressing donor MSCs (HIF-MSC) to angiogenesis by endothelial cells. Exosome secretion was enhanced in HIF-MSC...
  59. Cosenza S, Ruiz M, Toupet K, Jorgensen C, Noel D. Mesenchymal stem cells derived exosomes and microparticles protect cartilage and bone from degradation in osteoarthritis. Sci Rep. 2017;7:16214 pubmed publisher
    ..In OA-like chondrocytes, BM-MSC-derived MPs and Exos could reinduce the expression of chondrocyte markers (type II collagen, aggrecan) while ..
  60. Yun S, Yoon Y, Lee J, Kook M, Han Y, Jung S, et al. Tauroursodeoxycholic Acid Protects against the Effects of P-Cresol-Induced Reactive Oxygen Species via the Expression of Cellular Prion Protein. Int J Mol Sci. 2018;19: pubmed publisher
    ..and induces apoptosis and inflammation through reactive oxygen species (ROS), we observed ER stress-induced MSC apoptosis activated by oxidative stress, which in turn resulted from ROS generation...
  61. Szabo I, Trentin L, Trimarco V, Semenzato G, Leanza L. Biophysical characterization and expression analysis of Kv1.3 potassium channel in primary human leukemic B cells. Cell Physiol Biochem. 2015;37:965-78 pubmed publisher
    ..B-CLL cells were co-cultured with mesenchymal stromal cells (MSC) and Kv1.3 inhibitor-induced apoptosis was assessed. We demonstrate that Kv1...
  62. Diederichs S, Gabler J, Autenrieth J, Kynast K, Merle C, Walles H, et al. Differential Regulation of SOX9 Protein During Chondrogenesis of Induced Pluripotent Stem Cells Versus Mesenchymal Stromal Cells: A Shortcoming for Cartilage Formation. Stem Cells Dev. 2016;25:598-609 pubmed publisher
    ..chondrogenic differentiation of two human iPSC lines in a comparable manner like during mesenchymal stromal cell (MSC) chondrogenesis...
  63. Munir H, Luu N, Clarke L, Nash G, McGettrick H. Comparative Ability of Mesenchymal Stromal Cells from Different Tissues to Limit Neutrophil Recruitment to Inflamed Endothelium. PLoS ONE. 2016;11:e0155161 pubmed publisher
    Mesenchymal stromal cells (MSC) are tissue-resident stromal cells capable of modulating immune responses, including leukocyte recruitment by endothelial cells (EC)...
  64. Zhou C, Zou J, Zou S, Li X. INO80 is Required for Osteogenic Differentiation of Human Mesenchymal Stem Cells. Sci Rep. 2016;6:35924 pubmed publisher
    Bone marrow derived human mesenchymal stem cells (MSC) are a great source in bone tissue engineering. However, how to improve the efficiency of MSC osteogenesis remains a big challenge in bone regenerative medicine...
  65. Esteves C, Sheldrake T, Mesquita S, Pesántez J, Menghini T, Dawson L, et al. Isolation and characterization of equine native MSC populations. Stem Cell Res Ther. 2017;8:80 pubmed publisher
    In contrast to humans in which mesenchymal stem/stromal cell (MSC) therapies are still largely in the clinical trial phase, MSCs have been used therapeutically in horses for over 15 years, thus constituting a valuable preclinical ..
  66. Cheng W, Su J, Hu Y, Huang Q, Shi H, Wang L, et al. Interleukin-25 primed mesenchymal stem cells achieve better therapeutic effects on dextran sulfate sodium-induced colitis via inhibiting Th17 immune response and inducing T regulatory cell phenotype. Am J Transl Res. 2017;9:4149-4160 pubmed
    This study aimed to investigate the anti-inflammatory mechanism of IL-25 mediated mesenchymal stem cells (MSC) treatment for inflammatory bowel disease (IBD) in a DSS-induced rat colitis model.
  67. Wang J, Li D, Li X, Zhou P, Ju X. [Effect of Human Umbilical Cord Mesenchymal Stem Cells on Etoposide-induced Nalm-6 Cell Apoptosis]. Zhongguo Shi Yan Xue Ye Xue Za Zhi. 2016;24:178-83 pubmed publisher
    To investigate the effect of human umbilical cord mesenchymal stem cells (hUC-MSC) on VP16-induced apoptosis of Nalm-6 cells...
  68. Badner A, Vawda R, Laliberte A, Hong J, Mikhail M, Jose A, et al. Early Intravenous Delivery of Human Brain Stromal Cells Modulates Systemic Inflammation and Leads to Vasoprotection in Traumatic Spinal Cord Injury. Stem Cells Transl Med. 2016;5:991-1003 pubmed publisher
    ..This study demonstrates that these cells not only display a MSC phenotype in vitro but also have similar in vivo immunomodulatory effects after spinal cord injury that are more ..
  69. de Lima K, de Oliveira G, Yaochite J, Pinheiro D, de Azevedo J, Silva W, et al. Transcriptional profiling reveals intrinsic mRNA alterations in multipotent mesenchymal stromal cells isolated from bone marrow of newly-diagnosed type 1 diabetes patients. Stem Cell Res Ther. 2016;7:92 pubmed publisher
    ..supported previous literature reports, while also detecting new potential molecules related to bone marrow-derived MSC functions...
  70. Shafiee A, Patel J, Wong H, Donovan P, Hutmacher D, Fisk N, et al. Priming of endothelial colony-forming cells in a mesenchymal niche improves engraftment and vasculogenic potential by initiating mesenchymal transition orchestrated by NOTCH signaling. FASEB J. 2017;31:610-624 pubmed publisher
    ..b>MSC coculture altered ECFC appearance to an elongated mesenchymal morphology with reduced proliferation...
  71. Niu Y, Li Q, Xie R, Liu S, Wang R, Xing P, et al. Modulating the phenotype of host macrophages to enhance osteogenesis in MSC-laden hydrogels: Design of a glucomannan coating material. Biomaterials. 2017;139:39-55 pubmed publisher
  72. Zhang S, Zhang H, Zhang Y. Quantification of selenomethionine in plasma using UPLC-MS/MS after the oral administration of selenium-enriched yeast to rats. Food Chem. 2018;241:1-6 pubmed publisher
    ..After a simple extraction with perchloric acid, SeMet and the internal standard methylselenocysteine (MSC) were separated on a C18 column with isocratic elution of water:acetonitrile:formic acid (99:1:0...
  73. Coffman L, Choi Y, McLean K, Allen B, di Magliano M, Buckanovich R. Human carcinoma-associated mesenchymal stem cells promote ovarian cancer chemotherapy resistance via a BMP4/HH signaling loop. Oncotarget. 2016;7:6916-32 pubmed publisher
    ..We demonstrate here that ovarian tumor cell-secreted Hedgehog (HH) induces CA-MSC BMP4 expression...
  74. Wang X, Wu R, Ling J, Liu M, Zhang L, Lin L, et al. [Study on the Rapid Detection of Triazophos Residues in Flesh of Navel Orange by Using Surface-Enhanced Raman Scattering]. Guang Pu Xue Yu Guang Pu Fen Xi. 2016;36:736-42 pubmed
    ..Three preprocessing methods such as normalization, MSC and SNV were used to optimize Raman signals and PLS models were set up...
  75. Bruna F, Arango Rodríguez M, Plaza A, Espinoza I, Conget P. The administration of multipotent stromal cells at precancerous stage precludes tumor growth and epithelial dedifferentiation of oral squamous cell carcinoma. Stem Cell Res. 2017;18:5-13 pubmed publisher
    ..Our aim was to determine whether MSC administration at precancerous stage modifies the natural progression of OSCC...
  76. Tautenhahn H, Brückner S, Uder C, Erler S, Hempel M, von Bergen M, et al. Mesenchymal stem cells correct haemodynamic dysfunction associated with liver injury after extended resection in a pig model. Sci Rep. 2017;7:2617 pubmed publisher
    ..These signs of hepatorenal dysfunction and haemodynamic impairment were corrected by MSC treatment. MSCs elevated PDGF levels in the serum, possibly contributing to circulatory homeostasis...
  77. Chierchia A, Chirico N, Boeri L, Raimondi I, Riva G, Raimondi M, et al. Secretome released from hydrogel-embedded adipose mesenchymal stem cells protects against the Parkinson's disease related toxin 6-hydroxydopamine. Eur J Pharm Biopharm. 2017;121:113-120 pubmed publisher
    ..factors as cytokines, chemokines and angiogenic molecules, collectively named secretome, that accumulate in MSC culture medium. However, lasting cell-free administration of secretome in vitro or in vivo is challenging...
  78. Rossnagl S, Ghura H, Groth C, Altrock E, Jakob F, Schott S, et al. A Subpopulation of Stromal Cells Controls Cancer Cell Homing to the Bone Marrow. Cancer Res. 2018;78:129-142 pubmed publisher
    ..We characterize here the elusive premetastatic niche by examining the role of mesenchymal stromal cells (MSC) in cancer cell homing...
  79. Yang J, Gao F, Zhang Y, Liu Y, Zhang D. Buyang Huanwu Decoction (BYHWD) Enhances Angiogenic Effect of Mesenchymal Stem Cell by Upregulating VEGF Expression After Focal Cerebral Ischemia. J Mol Neurosci. 2015;56:898-906 pubmed publisher
    ..Previously, we have demonstrated that BYHWD combined with mesenchymal stem cell (MSC) transplantation attenuates ischemic injury partly by upregulating angiogenesis...
  80. Müller W, Tolba E, Ackermann M, Neufurth M, Wang S, Feng Q, et al. Fabrication of amorphous strontium polyphosphate microparticles that induce mineralization of bone cells in vitro and in vivo. Acta Biomater. 2017;50:89-101 pubmed publisher
    ..on growth and gene expression were investigated with SaOS-2 cells as well as with human mesenchymal stem cells (MSC) and compared with those particles prepared of amorphous calcium-polyphosphate ("Ca-a-polyP-MP") and of strontium ..
  81. Silini A, Cancelli S, Signoroni P, Cargnoni A, Magatti M, Parolini O. The dichotomy of placenta-derived cells in cancer growth. Placenta. 2017;59:154-162 pubmed publisher
    Placenta-derived mesenchymal stromal cells (MSC) have often been considered to linger behind their equivalents from other tissues, such as MSC from bone marrow, in many aspects including their therapeutic potential in regenerative ..
  82. Uklejewski R, Rogala P, Winiecki M, Tokłowicz R, Ruszkowski P, Wołuń Cholewa M. Biomimetic Multispiked Connecting Ti-Alloy Scaffold Prototype for Entirely-Cementless Resurfacing Arthroplasty Endoprostheses-Exemplary Results of Implantation of the Ca-P Surface-Modified Scaffold Prototypes in Animal Model and Osteoblast Culture Ev. Materials (Basel). 2016;9: pubmed publisher
    ..manufactured, and tested by our research team-the Ti-alloy prototype of the multispiked connecting scaffold (MSC-Scaffold) interfacing the components of resurfacing arthroplasty (RA) endoprostheses with bone...
  83. Combs S, Kessel C, Wilkens J, Multhoff G, Schmid T, Vaupel P, et al. Master of Science (MSc) Program in Radiation Biology: An Interdepartmental Course Bridging the Gap between Radiation-Related Preclinical and Clinical Disciplines to Prepare Next-Generation Medical Scientists. Front Oncol. 2017;7:226 pubmed publisher
    ..At the Technical University of Munich (TUM), a full Master of Science (MSc) course in radiation biology has been established...
  84. Liu L, Hua Z, Shen J, Yin Y, Yang J, Cheng K, et al. Comparative Efficacy of Multiple Variables of Mesenchymal Stem Cell Transplantation for the Treatment of Neuropathic Pain in Rats. Mil Med. 2017;182:175-184 pubmed publisher
    ..Mesenchymal stem cell transplantation (MSC) has shown promise as an emerging therapy for neuropathic pain...
  85. Díaz Tocados J, Herencia C, Martinez Moreno J, Montes de Oca A, Rodriguez Ortiz M, Vergara N, et al. Magnesium Chloride promotes Osteogenesis through Notch signaling activation and expansion of Mesenchymal Stem Cells. Sci Rep. 2017;7:7839 pubmed publisher
    Mesenchymal stem cells (MSC) are osteoblasts progenitors and a variety of studies suggest that they may play an important role for the health in the field of bone regeneration...
  86. Zhang S, Zeng N, Alowayed N, Singh Y, Cheng A, Lang F, et al. Downregulation of endometrial mesenchymal marker SUSD2 causes cell senescence and cell death in endometrial carcinoma cells. PLoS ONE. 2017;12:e0183681 pubmed publisher
    ..Cell adhesion and migration are modified by the mesenchymal stem cell (MSC) marker Sushi domain containing 2 (SUSD2), a type I transmembrane protein that participates in the orchestration of ..
  87. Montanari E, Meier R, Mahou R, Seebach J, Wandrey C, Gerber Lemaire S, et al. Multipotent mesenchymal stromal cells enhance insulin secretion from human islets via N-cadherin interaction and prolong function of transplanted encapsulated islets in mice. Stem Cell Res Ther. 2017;8:199 pubmed publisher
    Multipotent mesenchymal stromal cells (MSC) enhance viability and function of islets of Langerhans. We aimed to examine the interactions between human MSC and human islets of Langerhans that influence the function of islets...
  88. Giebel B, Kordelas L, Börger V. Clinical potential of mesenchymal stem/stromal cell-derived extracellular vesicles. Stem Cell Investig. 2017;4:84 pubmed publisher
    ..Meanwhile, MSC-EVs have been applied to an increasing amount of different animal models and were tested in a patient suffering ..
  89. Somoza R, Acevedo C, Albornoz F, Luz Crawford P, Carrión F, Young M, et al. TGFβ3 secretion by three-dimensional cultures of human dental apical papilla mesenchymal stem cells. J Tissue Eng Regen Med. 2017;11:1045-1056 pubmed publisher
    ..from dental tissues, such as pulp and periodontal ligament; the dental apical papilla (DAP) is a less-studied MSC source...
  90. Ribeiro A, Ritter T, Griffin M, Ceredig R. Development of a flow cytometry-based potency assay for measuring the in vitro immunomodulatory properties of mesenchymal stromal cells. Immunol Lett. 2016;177:38-46 pubmed publisher
    Human bone marrow-derived mesenchymal stromal/stem cells (MSC) have well-documented modulatory effects on multiple immune cell types...
  91. Jakobsen K, Grønhøj C, Jensen D, Fischer Nielsen A, Hjuler T, Von Buchwald C. Mesenchymal stem cell therapy for laryngotracheal stenosis: A systematic review of preclinical studies. PLoS ONE. 2017;12:e0185283 pubmed publisher
    ..Mesenchymal stem cells (MSCs) therapy has shown promising results in regenerative medicine. We aimed to systematically review the literature on MSC therapy for stenosis of the conductive airways.
  92. Zhu L, Huang X, Yu W, Chen H, Chen Y, Dai Y. Transplantation of adipose tissue-derived stem cell-derived exosomes ameliorates erectile function in diabetic rats. Andrologia. 2017;: pubmed publisher
    ..Exosomes excreted from MSCs have emerged as physiologically relevant and powerful components of the MSC secretome...