MondoA

Summary

Gene Symbol: MondoA
Description: MLX interacting protein
Alias: MIR, MONDOA, bHLHe36, MLX-interacting protein, Mlx interactor, class E basic helix-loop-helix protein 36, transcriptional activator MondoA
Species: human
Products:     MondoA

Top Publications

  1. Eilers A, Sundwall E, Lin M, Sullivan A, Ayer D. A novel heterodimerization domain, CRM1, and 14-3-3 control subcellular localization of the MondoA-Mlx heterocomplex. Mol Cell Biol. 2002;22:8514-26 pubmed
    Among members of the bHLHZip family of transcriptional regulators, MondoA and Mlx have the unique property of cytoplasmic localization...
  2. Kaadige M, Looper R, Kamalanaadhan S, Ayer D. Glutamine-dependent anapleurosis dictates glucose uptake and cell growth by regulating MondoA transcriptional activity. Proc Natl Acad Sci U S A. 2009;106:14878-83 pubmed publisher
    ..The MondoA transcription factor forms a heterocomplex with its obligate partner Mlx to regulate approximately 75% of glucose-..
  3. Yu F, Luo Y. Tandem ChoRE and CCAAT motifs and associated factors regulate Txnip expression in response to glucose or adenosine-containing molecules. PLoS ONE. 2009;4:e8397 pubmed publisher
    ..This piece of information will be helpful for future dissection of molecular mechanisms governing the transcriptional regulation of Txnip, a glucose responsive gene. ..
  4. Peterson C, Stoltzman C, Sighinolfi M, Han K, Ayer D. Glucose controls nuclear accumulation, promoter binding, and transcriptional activity of the MondoA-Mlx heterodimer. Mol Cell Biol. 2010;30:2887-95 pubmed publisher
    ..The basic helix-loop-helix-leucine zipper (bHLHZip) transcription factor complex MondoA-Mlx plays a central role in the transcriptional response to intracellular glucose concentration...
  5. Sans C, Satterwhite D, Stoltzman C, Breen K, Ayer D. MondoA-Mlx heterodimers are candidate sensors of cellular energy status: mitochondrial localization and direct regulation of glycolysis. Mol Cell Biol. 2006;26:4863-71 pubmed
    ..b>MondoA is a basic helix-loop-helix leucine zipper transcriptional activator similar to Myc in function...
  6. Stoltzman C, Peterson C, Breen K, Muoio D, Billin A, Ayer D. Glucose sensing by MondoA:Mlx complexes: a role for hexokinases and direct regulation of thioredoxin-interacting protein expression. Proc Natl Acad Sci U S A. 2008;105:6912-7 pubmed publisher
    ..We recently reported that the MondoA:Mlx dimeric transcription factor directly regulates glycolysis...
  7. Tutar Y. miRNA and cancer; computational and experimental approaches. Curr Pharm Biotechnol. 2014;15:429 pubmed
    ..Dr. Vasconcelos showed that overexpression of miR-128 decreased acute myeloid leukemia cells and increased the DNA damage...
  8. Kiang J, Smith J, Anderson M, Elliott T, Gupta P, Balakathiresan N, et al. Hemorrhage enhances cytokine, complement component 3, and caspase-3, and regulates microRNAs associated with intestinal damage after whole-body gamma-irradiation in combined injury. PLoS ONE. 2017;12:e0184393 pubmed publisher
    ..Among the altered miRNAs, CI increased miR-34 in the serum and ileum which targeted an increased phosphorylation of ERK, p38, and increased NF-?B, thereby ..
  9. Lim E, Lim J, Kim E, Kim Y, Shin J, Seok P, et al. Xylobiose, an Alternative Sweetener, Ameliorates Diabetes-Related Metabolic Changes by Regulating Hepatic Lipogenesis and miR-122a/33a in db/db Mice. Nutrients. 2016;8: pubmed
    ..The expression levels of miR-122a and miR-33a were higher and lower in the XB group, respectively...

More Information

Publications147 found, 100 shown here

  1. Murata M. Inflammation and cancer. Environ Health Prev Med. 2018;23:50 pubmed publisher
    ..Quantitative RT-PCR analysis confirmed the concordant downregulation of miR-497 in cancer tissues and plasma, suggesting that plasma miR-497 could be used as a diagnostic biomarker for ..
  2. Erice O, Munoz Garrido P, Vaquero J, Perugorria M, Fernández Barrena M, Saez E, et al. MicroRNA-506 promotes primary biliary cholangitis-like features in cholangiocytes and immune activation. Hepatology. 2018;67:1420-1440 pubmed publisher
    ..MicroRNA (miR) dysregulation occurs in liver and immune cells of PBC patients, but its functional relevance is largely unknown...
  3. Mazzio E, Soliman K. HTP Nutraceutical Screening for Histone Deacetylase Inhibitors and Effects of HDACis on Tumor-suppressing miRNAs by Trichostatin A and Grapeseed (Vitis vinifera) in HeLa cells. Cancer Genomics Proteomics. 2017;14:17-33 pubmed
    ..g. hsa-miR-23b-5p, hsa-miR-27b-5p, hsa-miR-1180-3p, hsa-miR-6880-5p and hsa-mir-943)...
  4. Zou H, Wang Y, Gang Q, Zhang Y, Sun Y. Plasma level of miR-93 is associated with higher risk to develop type 2 diabetic retinopathy. Graefes Arch Clin Exp Ophthalmol. 2017;255:1159-1166 pubmed publisher
    MicroRNA-93 (miR-93) usually acts as a promoter of tumor progression in several human carcinomas. It has been found distinctly high in eyes with proliferative diabetic retinopathy (DR)...
  5. Bhatia H, Pattnaik B, Datta M. Inhibition of mitochondrial β-oxidation by miR-107 promotes hepatic lipid accumulation and impairs glucose tolerance in vivo. Int J Obes (Lond). 2016;40:861-9 pubmed publisher
    ..In our previous study, we had demonstrated that fatty acid synthase (FASN) is a target of miR-107...
  6. Huang Y, Yang Y, Huang F, Tiao M, Lin Y, Tsai M, et al. MicroRNA-29a mitigation of endoplasmic reticulum and autophagy aberrance counteracts in obstructive jaundice-induced fibrosis in mice. Exp Biol Med (Maywood). 2017;:1535370217741500 pubmed publisher
    ..We have previously shown that microRNA-29a (miR-29a) protects against liver fibrosis...
  7. Bhattacharjya S, Roy K, Ganguly A, Sarkar S, Panda C, Bhattacharyya D, et al. Inhibition of nucleoporin member Nup214 expression by miR-133b perturbs mitotic timing and leads to cell death. Mol Cancer. 2015;14:42 pubmed publisher
    ..Databases/bioinformatic tools such as miRBase, Oncomine and RNAhybrid predicted Nup214 as a miR-133b target. To validate this, we used luciferase reporter assays, Real-Time PCR and immuno-blotting...
  8. Zheng Y, Jiang S, Zhang Y, Zhang R, Gong D. Detection of miR-33 Expression and the Verification of Its Target Genes in the Fatty Liver of Geese. Int J Mol Sci. 2015;16:12737-52 pubmed publisher
    ..The examination of miR-33 expression and its target genes can promote the in-depth study of the miRNA regulation mechanism in the ..
  9. Chen H, Zhao J, Li Y, He L, Huang Y, Shu W, et al. Gene expression network regulated by DNA methylation and microRNA during microcystin-leucine arginine induced malignant transformation in human hepatocyte L02 cells. Toxicol Lett. 2018;289:42-53 pubmed publisher
    ..MiRNA-mRNA network and mRNA-mRNA network analysis showed that hsa-miR-320a, hsa-miR-331-3p, hsa-miR-26a-5p, hsa-miR-196a-5p, hsa-miR-221-3p, coiled-coil domain containing 180 (CCDC180), ..
  10. Smith J, Jeng S, McWeeney S, Hirsch A. A MicroRNA Screen Identifies the Wnt Signaling Pathway as a Regulator of the Interferon Response during Flavivirus Infection. J Virol. 2017;91: pubmed publisher
    ..Several families of miRNAs were identified as inhibiting multiple flaviviruses, including the miRNA miR-34, miR-15, and miR-517 families...
  11. Jia K, Pan S, Ding H, Liu J, Zheng Y, Wang S, et al. Chaihu-shugan san inhibits inflammatory response to improve insulin signaling in liver and prefrontal cortex of CUMS rats with glucose intolerance. Biomed Pharmacother. 2018;103:1415-1428 pubmed publisher
    ..RT-qPCR and Western blot analysis, as well as microRNA-155 (miR-155) mimic or inhibitor transfection were used to explore possible association of MyD88 and miR-155...
  12. Liu M, Liu R, Wu H, Li Y, Su M, Dong M, et al. Radix puerariae extracts ameliorate paraquat-induced pulmonary fibrosis by attenuating follistatin-like 1 and nuclear factor erythroid 2p45-related factor-2 signalling pathways through downregulation of miRNA-21 expression. BMC Complement Altern Med. 2016;16:11 pubmed publisher
    ..We examined effects of miR-21 on follistatin-like 1 (Fstl 1) pathways and oxidative stress in the lung...
  13. Kodo K, Sugimoto S, Nakajima H, Mori J, Itoh I, Fukuhara S, et al. Erythropoietin (EPO) ameliorates obesity and glucose homeostasis by promoting thermogenesis and endocrine function of classical brown adipose tissue (BAT) in diet-induced obese mice. PLoS ONE. 2017;12:e0173661 pubmed publisher
    ..EPO's suppression of myocyte enhancer factor 2c (Mef2c) and microRNA-133a (miR-133a) via ?3-adrenergic receptor caused PRDM16 upregulation...
  14. Satishchandran A, Ambade A, Rao S, Hsueh Y, Iracheta Vellve A, Tornai D, et al. MicroRNA 122, Regulated by GRLH2, Protects Livers of Mice and Patients From Ethanol-Induced Liver Disease. Gastroenterology. 2018;154:238-252.e7 pubmed publisher
    ..and controls, were given injections of recombinant adeno-associated virus 8 vector that expressed the primary miR-122 transcript (pri-MIR122, to overexpress MIR122 in hepatocytes) or vector (control)...
  15. Janaki Ramaiah M, Lavanya A, Honarpisheh M, Zarea M, Bhadra U, Bhadra M. MiR-15/16 complex targets p70S6 kinase 1 and controls cell proliferation in MDA-MB-231 breast cancer cells. Gene. 2014;552:255-64 pubmed publisher
    ..To have a better insight of the role of miR-15/16 in regulating the cross talk of p53 and mTOR, we performed an in depth study in MDA-MB-231 breast cancer ..
  16. Henshall D, Hamer H, Pasterkamp R, Goldstein D, Kjems J, Prehn J, et al. MicroRNAs in epilepsy: pathophysiology and clinical utility. Lancet Neurol. 2016;15:1368-1376 pubmed publisher
    ..Early functional studies showed that silencing of brain-specific miR-134 using antisense oligonucleotides (antagomirs) had potent antiseizure effects in animal models, whereas genetic ..
  17. Chen D, Dixon B, Doycheva D, Li B, Zhang Y, Hu Q, et al. IRE1? inhibition decreased TXNIP/NLRP3 inflammasome activation through miR-17-5p after neonatal hypoxic-ischemic brain injury in rats. J Neuroinflammation. 2018;15:32 pubmed publisher
    ..In the present study, we sought to investigate whether microRNA-17 (miR-17), a potential IRE1? ribonuclease (RNase) substrate, arbitrates downregulation of thioredoxin-interacting protein ..
  18. Piletič K, Kunej T. MicroRNA epigenetic signatures in human disease. Arch Toxicol. 2016;90:2405-19 pubmed publisher
    ..The review revealed that hsa-miR-34a, hsa-miR-34b, and hsa-miR-34c are the most frequently reported epigenetically dysregulated miRNAs...
  19. Liu D, Han L, Wu X, Yang X, Zhang Q, Jiang F. Genome-wide microRNA changes in human intracranial aneurysms. BMC Neurol. 2014;14:188 pubmed publisher
    ..The changed microRNAs included endothelium-enriched microRNAs such as members of the let-7 family, miR-17, miR-23b, miR-126, hsa-miR-24-1 and miR-222, and vascular smooth muscle-enriched miRNAs such as miR-143 and miR-..
  20. Kuwano Y, Nishida K, Kajita K, Satake Y, Akaike Y, Fujita K, et al. Transformer 2β and miR-204 regulate apoptosis through competitive binding to 3' UTR of BCL2 mRNA. Cell Death Differ. 2015;22:815-25 pubmed publisher
    ..respectively, showed that Tra2β bound to BCL2α 3' UTR, and that Tra2β knockdown facilitated association of miR-204 with BCL2α 3' UTR...
  21. Zhan C, Chen D, Luo J, Shi Y, Zhang Y. Protective role of down-regulated microRNA-31 on intestinal barrier dysfunction through inhibition of NF-κB/HIF-1α pathway by binding to HMOX1 in rats with sepsis. Mol Med. 2018;24:55 pubmed publisher
    ..Herein, we evaluate the effect of microRNA-31 (miR-31) on intestinal barrier dysfunction through NF-κB/HIF-1α pathway by targeting HMOX1 in rats with sepsis...
  22. Pérez García A, Dongil P, Hurtado Carneiro V, Blazquez E, Sanz C, Alvarez E. High-fat diet alters PAS kinase regulation by fasting and feeding in liver. J Nutr Biochem. 2018;57:14-25 pubmed publisher
    ..The expression of miR-33a and miR-143 changes in PASK-deficient mice with an HFD...
  23. Yang Z, Wang Y, Jia B, Mao G, Lv Y, Wang G, et al. Downregulation of miR-146a, cyclooxygenase-2 and advanced glycation end-products in simvastatin-treated older patients with hyperlipidemia. Geriatr Gerontol Int. 2016;16:322-8 pubmed publisher
    ..We tested miR-146a, interleukin-1-receptor-associated kinase 1, tumor necrosis factor-receptor-associated factor 6 ..
  24. Qureshi A, Khan D, Mushtaq S, Ye S, Xiong M, Qureshi N. ?-Tocotrienol feeding modulates gene expression of EIF2, mTOR, protein ubiquitination through multiple-signaling pathways in chronic hepatitis C patients. Lipids Health Dis. 2018;17:167 pubmed publisher
    ..regulators (85) were involved with cAMP, STAT2, 26S proteasome, CSF1, IFN?, LDL, TGFA, and microRNA-155-5p, miR-223, miR-21-5p...
  25. Hirakawa T, Nasu K, Abe W, Aoyagi Y, Okamoto M, Kai K, et al. miR-503, a microRNA epigenetically repressed in endometriosis, induces apoptosis and cell-cycle arrest and inhibits cell proliferation, angiogenesis, and contractility of human ovarian endometriotic stromal cells. Hum Reprod. 2016;31:2587-2597 pubmed
    Is the micro-RNA (miRNA) miR-503, downregulated in endometriotic cyst stromal cells (ECSCs) and does this affect the cell cycle, cell proliferation, angiogenesis and contractility of these cells? SUMMARY ANSWER: miR-503 expression is ..
  26. Guo Y, Li P, Gao L, Zhang J, Yang Z, Bledsoe G, et al. Kallistatin reduces vascular senescence and aging by regulating microRNA-34a-SIRT1 pathway. Aging Cell. 2017;16:837-846 pubmed publisher
    ..Kallistatin blocked TNF-?-induced superoxide levels, NADPH oxidase activity, and microRNA-21 (miR-21) and p16INK4a synthesis...
  27. Feng X, Tan W, Cheng S, Wang H, Ye S, Yu C, et al. Upregulation of microRNA-126 in hepatic stellate cells may affect pathogenesis of liver fibrosis through the NF-κB pathway. DNA Cell Biol. 2015;34:470-80 pubmed publisher
    ..regulation of nuclear factor kappa B (NF-κB) inhibitor alpha (IκBα) and its possible signaling pathway by miR-126 in human hepatic stellate cell (HSC) line LX-2...
  28. Hu J, Lv G, Zhou S, Zhou Y, Nie B, Duan H, et al. The Downregulation of MiR-182 Is Associated with the Growth and Invasion of Osteosarcoma Cells through the Regulation of TIAM1 Expression. PLoS ONE. 2015;10:e0121175 pubmed publisher
    ..b>MiR-182 expression level in osteosarcoma cell lines and tissues were assayed by qRT-PCR...
  29. Mock K, Preca B, Brummer T, Brabletz S, Stemmler M, Brabletz T. The EMT-activator ZEB1 induces bone metastasis associated genes including BMP-inhibitors. Oncotarget. 2015;6:14399-412 pubmed
    ..both by directly increasing their gene transcription, as well as by indirectly suppressing their reduction via miR-200 family members. Consequently, ZEB1 stimulates BMP-inhibitor mediated osteoclast differentiation...
  30. Hunt E, Broyles D, Head T, Deo S. MicroRNA Detection: Current Technology and Research Strategies. Annu Rev Anal Chem (Palo Alto Calif). 2015;8:217-37 pubmed publisher
    The relatively new field of microRNA (miR) has experienced rapid growth in methodology associated with its detection and bioanalysis as well as with its role in -omics research, clinical diagnostics, and new therapeutic strategies...
  31. Yuan M, Tang Y, Zhou C, Liu F, Chen L, Yuan H. Elevated plasma CaM expression in patients with acute cerebral infarction predicts poor outcomes and is inversely associated with miR-26b expression. Int J Neurosci. 2016;126:408-14 pubmed publisher
    ..The expression levels of miR-26b change significantly during ACI, and bioinformatic analyses predict that miR-26b would be a potential regulator ..
  32. Jin X, Chen D, Zheng R, Zhang H, Chen Y, Xiang Z. miRNA-133a-UCP2 pathway regulates inflammatory bowel disease progress by influencing inflammation, oxidative stress and energy metabolism. World J Gastroenterol. 2017;23:76-86 pubmed publisher
    To investigate the role of the miR-133a-UCP2 pathway in the pathogenesis of inflammatory bowel disease (IBD) and to explore the potential downstream mechanisms with respect to inflammation, oxidative stress and energy metabolism...
  33. Tao Y, Qiang J, Yin G, Xu P, Shi Q, Bao J. Identification and characterization of lipid metabolism-related microRNAs in the liver of genetically improved farmed tilapia (GIFT, Oreochromis niloticus) by deep sequencing. Fish Shellfish Immunol. 2017;69:227-235 pubmed publisher
    ..0. Six known miRNAs (miR-30a-5p, miR-34a, miR-145-5p, miR-29a, miR-205-5p, and miR-23a-3p) that were differentially expressed between the ..
  34. Xie Z, Chen W, Chen Y, Wang X, Gao W, Liu Y. miR-768-3p is involved in the proliferation, invasion and migration of non-small cell lung carcinomas. Int J Oncol. 2017;51:1574-1582 pubmed publisher
    ..However, the possible roles of miR-768-3p in the pathological changes of lung carcinomas are still unknown...
  35. Kumar V, Mansfield J, Fan R, MACLEAN A, Li J, Mohan M. miR-130a and miR-212 Disrupt the Intestinal Epithelial Barrier through Modulation of PPAR? and Occludin Expression in Chronic Simian Immunodeficiency Virus-Infected Rhesus Macaques. J Immunol. 2018;200:2677-2689 pubmed publisher
    ..We bioinformatically crossed the predicted miRNA targets to transcriptomic data and characterized miR-130a and miR-212 as both were predicted to interact with critical epithelial barrier-associated genes...
  36. Li J, Chen Y, Guo X, Zhou L, Jia Z, Tang Y, et al. Inhibition of miR-15b decreases cell migration and metastasis in colorectal cancer. Tumour Biol. 2016;37:8765-73 pubmed publisher
    ..This study investigated the role of circulating miR-15b in the prediction of CRC recurrence and the associated mechanism...
  37. Sun Q, Zhang W, Guo Y, Li Z, Chen X, Wang Y, et al. Curcumin inhibits cell growth and induces cell apoptosis through upregulation of miR-33b in gastric cancer. Tumour Biol. 2016;37:13177-13184 pubmed
    ..The first stage of our studies showed that curcumin affected the expression of miR-33b, which, in turn, affected the expression of the X-linked inhibitor of apoptosis protein (XIAP) messenger RNA (..
  38. Ma Y, Wang P, Xue Y, Qu C, Zheng J, Liu X, et al. PVT1 affects growth of glioma microvascular endothelial cells by negatively regulating miR-186. Tumour Biol. 2017;39:1010428317694326 pubmed publisher
    ..Bioinformatics software and dual-luciferase system analysis confirmed that PVT1 acts by targeting miR-186...
  39. Liu X, Zheng J, Xue Y, Qu C, Chen J, Wang Z, et al. Inhibition of TDP43-Mediated SNHG12-miR-195-SOX5 Feedback Loop Impeded Malignant Biological Behaviors of Glioma Cells. Mol Ther Nucleic Acids. 2018;10:142-158 pubmed publisher
    ..Downregulation of TDP43 or SNHG12 significantly inhibited malignant biological behaviors of glioma cells. miR-195, downregulated in glioma tissues and cells, significantly impaired the malignant progression of glioma cells...
  40. Liang T, Lou J. Increased Expression of mir-34a-5p and Clinical Association in Acute Ischemic Stroke Patients and in a Rat Model. Med Sci Monit. 2016;22:2950-5 pubmed
    ..742, p<0.05). CONCLUSIONS Our results suggest there is a potential regulatory role of miRNA-34a-5p in acute ischemic stroke, which could serve as a therapeutic target or biomarker in stroke prognosis. ..
  41. Cao X, Lai S, Hu F, Li G, Wang G, Luo X, et al. miR-19a contributes to gefitinib resistance and epithelial mesenchymal transition in non-small cell lung cancer cells by targeting c-Met. Sci Rep. 2017;7:2939 pubmed publisher
    ..In this study, we show that miR-19a is significantly down-regulated in gefitinib-resistant NSCLC cell lines compared with gefitinib-sensitive cell ..
  42. Yuan G, Wang K, Mou X, Luo R, Dou W, Wang J. Molecular cloning, mRNA expression and alternative splicing of a ryanodine receptor gene from the citrus whitefly, Dialeurodes citri (Ashmead). Pestic Biochem Physiol. 2017;142:59-66 pubmed publisher
    ..DcRyR shares many features of insect and vertebrate RyRs, including a MIR domain, two RIH domains, three SPRY domains, four copies of RyR repeat domain, RIH-associated domain at the N-..
  43. Zheng C, Zheng Z, Sun J, Zhang Y, Wei C, Ke X, et al. MiR-16-5p mediates a positive feedback loop in EV71-induced apoptosis and suppresses virus replication. Sci Rep. 2017;7:16422 pubmed publisher
    ..We previously reported that miR-16-5p increases with severity of HFMD by investigating the expression patterns of host miRNAs in patients with HFMD...
  44. Jones M, Quinton L, Blahna M, Neilson J, Fu S, Ivanov A, et al. Zcchc11-dependent uridylation of microRNA directs cytokine expression. Nat Cell Biol. 2009;11:1157-63 pubmed publisher
    ..The miR-26 family of miRNAs targets IL-6, and the addition of terminal uridines to the miR-26 3' end abrogates IL-6 ..
  45. Tian K, Di R, Wang L. MicroRNA-23a enhances migration and invasion through PTEN in osteosarcoma. Cancer Gene Ther. 2015;22:351-9 pubmed publisher
    To investigate the biological significance of abundant microRNA-23a (miR-23a) expression in osteosarcoma and its correlation with PTEN in the pathogenesis of osteosarcoma migration and invasion...
  46. Wei Y, Zhou W, Li X, Chai Y, Yuan R, Xiang Y. Coupling hybridization chain reaction with catalytic hairpin assembly enables non-enzymatic and sensitive fluorescent detection of microRNA cancer biomarkers. Biosens Bioelectron. 2016;77:416-20 pubmed publisher
    ..an enzyme-free and dual amplified approach for highly sensitive detection of a human prostate cancer biomarker, miR-141...
  47. Yang M, Liu R, Li X, Liao J, Pu Y, Pan E, et al. Epigenetic Repression of miR-218 Promotes Esophageal Carcinogenesis by Targeting ROBO1. Int J Mol Sci. 2015;16:27781-95 pubmed publisher
    b>miR-218, consisting of miR-218-1 at 4p15.31 and miR-218-2 at 5q35.1, was significantly decreased in esophageal squamous cell carcinoma (ESCC) in our previous study...
  48. Song H, Zhang Y, Liu N, Zhao S, Kong Y, Yuan L. miR-92a-3p Exerts Various Effects in Glioma and Glioma Stem-Like Cells Specifically Targeting CDH1/?-Catenin and Notch-1/Akt Signaling Pathways. Int J Mol Sci. 2016;17: pubmed
    ..Recently, miR-92a-3p was reported to be up-regulated in human glioma samples...
  49. Yuan X, Wang X, Chen C, Zhou J, Han M. Bone mesenchymal stem cells ameliorate ischemia/reperfusion-induced damage in renal epithelial cells via microRNA-223. Stem Cell Res Ther. 2017;8:146 pubmed publisher
    Recent studies have indicated that microRNA-223 (miR-223) plays a role in the tissue-protective effect of mesenchymal stem cells (MSCs)...
  50. Wang P, He Q, Liu C, He S, Zhu S, Li Y, et al. Functional polymorphism rs3783553 in the 3'-untranslated region of IL-1A increased the risk of ischemic stroke: A case-control study. Medicine (Baltimore). 2017;96:e8522 pubmed publisher
    ..that the vector containing the TTCA del allele exhibited a reduced transcriptional activity in the presence of miR-122 and miR-378...
  51. Brisotto G, di Gennaro A, Damiano V, Armellin M, Perin T, Maestro R, et al. An improved sequencing-based strategy to estimate locus-specific DNA methylation. BMC Cancer. 2015;15:639 pubmed publisher
    ..in cancer has been frequently associated with downregulation of microRNAs and protein coding genes, such as miR-200c/miR-141 cluster and E-cadherin...
  52. Shi J, Fu L, Ang Q, Wang G, Zhu J, Wang W. Overexpression of ATP1B1 predicts an adverse prognosis in cytogenetically normal acute myeloid leukemia. Oncotarget. 2016;7:2585-95 pubmed publisher
    ..0046, n = 162). In addition, up-regulation of oncogenes/onco-microRNAs such as MYCN, CCND2, CDK6, KIT and miR-155, among others, was associated with ATP1B1(high), which may be indicative of ATP1B1's leukemogenicity...
  53. Jović O. Durbin-Watson partial least-squares regression applied to MIR data on adulteration with edible oils of different origins. Food Chem. 2016;213:791-798 pubmed publisher
    ..The results obtained indicate that MIR-ATR, combined with dwPLS could be implemented to quantitative determination of edible-oil adulteration.
  54. Cui J, Ren Z, Zou W, Jiang Y. miR-497 accelerates oxidized low-density lipoprotein-induced lipid accumulation in macrophages by repressing the expression of apelin. Cell Biol Int. 2017;41:1012-1019 pubmed publisher
    microRNAs (miRNAs) play important roles in the pathogenesis of atherosclerosis. A previous study has reported that miR-497 is elevated in advanced atherosclerotic lesions in an apoE-deficient (apoE-/-) mouse model...
  55. Dong H, Hao X, Cui B, Guo M. MiR-429 suppresses glioblastoma multiforme by targeting SOX2. Cell Biochem Funct. 2017;35:260-268 pubmed publisher
    Accumulating evidence has shown that miR-429 plays an important role in the development and progression of tumour. However, the role of miR-429 in glioblastoma multiforme (GBM) remains largely unknown...
  56. Kong X, Duan L, Qian X, Xu D, Liu H, Zhu Y, et al. Tumor-suppressive microRNA-497 targets IKKβ to regulate NF-κB signaling pathway in human prostate cancer cells. Am J Cancer Res. 2015;5:1795-804 pubmed
    ..We used several Algorithms and confirmed that IKKβ is directly regulated by miR-497...
  57. Hadjimichael C, Nikolaou C, Papamatheakis J, Kretsovali A. MicroRNAs for Fine-Tuning of Mouse Embryonic Stem Cell Fate Decision through Regulation of TGF-β Signaling. Stem Cell Reports. 2016;6:292-301 pubmed publisher
    ..Among them, miR-191 and miR-16-1 are highly expressed in ESCs and repress Smad2, the most essential mediator of Activin-Nodal ..
  58. Zhou P, Jiang N, Zhang G, Sun Q. MiR-203 inhibits tumor invasion and metastasis in gastric cancer by ATM. Acta Biochim Biophys Sin (Shanghai). 2016;48:696-703 pubmed publisher
    ..In this study, we aimed to investigate the role of miR-203 in the invasion and metastasis of gastric cancer and the potential mechanism of the effect of miR-203 on the ..
  59. Fujii T, Shimada K, Asano A, Tatsumi Y, Yamaguchi N, Yamazaki M, et al. MicroRNA-331-3p Suppresses Cervical Cancer Cell Proliferation and E6/E7 Expression by Targeting NRP2. Int J Mol Sci. 2016;17: pubmed publisher
    ..In this study, we investigated the role of miR-331-3p in cell proliferation and the expression of keratinocyte differentiation markers of uterine cervical cancer ..
  60. Oka M, Medrano S, Sequeira Lόpez M, Gomez R. Chronic Stimulation of Renin Cells Leads to Vascular Pathology. Hypertension. 2017;70:119-128 pubmed publisher
    ..We also followed the expression of Akr1b7 and miR-330-5p, markers of cells programmed for the renin phenotype...
  61. Paikari A, D Belair C, Saw D, Blelloch R. The eutheria-specific miR-290 cluster modulates placental growth and maternal-fetal transport. Development. 2017;144:3731-3743 pubmed publisher
    The vertebrate-specific ESCC microRNA family arises from two genetic loci in mammals: miR-290/miR-371 and miR-302...
  62. Wang J, Yang H, Si Y, Hu D, Yu Y, Zhang Y, et al. Iodine Promotes Tumorigenesis of Thyroid Cancer by Suppressing Mir-422a and Up-Regulating MAPK1. Cell Physiol Biochem. 2017;43:1325-1336 pubmed publisher
    ..In this study, we aimed at investigating miRNA related signaling pathway in thyroid cancer cells...
  63. Wang J, Li H, Qiu S, Dong Z, Xiang X, Zhang D. MBD2 upregulates miR-301a-5p to induce kidney cell apoptosis during vancomycin-induced AKI. Cell Death Dis. 2017;8:e3120 pubmed publisher
    ..Interestingly, knockdown of MBD2 by siRNA was associated with the suppression of miR-301a-5p...
  64. Krasoudaki E, Banos A, Stagakis E, Loupasakis K, Drakos E, Sinatkas V, et al. Micro-RNA analysis of renal biopsies in human lupus nephritis demonstrates up-regulated miR-422a driving reduction of kallikrein-related peptidase 4. Nephrol Dial Transplant. 2016;31:1676-86 pubmed publisher
    ..b>miR-422a showed the highest upregulation (17-fold) in active LN and correlated with fibrinoid necrosis lesions (β = ..
  65. Zhang D, Li Y, Yao X, Zhao L, Jiang H, Yao X, et al. miR-182 Regulates Metabolic Homeostasis by Modulating Glucose Utilization in Muscle. Cell Rep. 2016;16:757-68 pubmed publisher
    ..Here, we show that miR-182 is highly expressed in fast-twitch muscle and negatively correlates with blood glucose level...
  66. Li Z, Lan Y, Zhao K, Lv X, Ding N, Lu H, et al. miR-142-5p Disrupts Neuronal Morphogenesis Underlying Porcine Hemagglutinating Encephalomyelitis Virus Infection by Targeting Ulk1. Front Cell Infect Microbiol. 2017;7:155 pubmed publisher
    ..Here, we report that miR-142-5p is localized to neurons and negatively regulates neuronal morphogenesis in porcine hemagglutinating ..
  67. Cheng L, Zhou R, Chen M, Feng L, Li H. MicroRNA-150 targets Rho-associated protein kinase 1 to inhibit cell proliferation, migration and invasion in papillary thyroid carcinoma. Mol Med Rep. 2017;16:2217-2224 pubmed publisher
    ..The present study aimed to investigate the expression, functional roles of microRNA?150 (miR?150) and its direct target gene in PTC...
  68. Ruibin W, Zheng X, Chen J, Zhang X, Yang X, Lin Y. Micro RNA-1298 opposes the effects of chronic oxidative stress on human trabecular meshwork cells via targeting on EIF4E3. Biomed Pharmacother. 2018;100:349-357 pubmed publisher
    This study aimed to investigate the effect and potential mechanism of miR-1298 in the progression of human trabecular meshwork (HTM) cells...
  69. Xu W, Li B, Zhao J, Yang J, Li J, Tsao S, et al. IGF2 induces CD133 expression in esophageal cancer cells to promote cancer stemness. Cancer Lett. 2018;425:88-100 pubmed publisher
    ..Further functional analysis identified miR-377 as a downstream regulator of PI3K/AKT signaling, and a mediator of the effects of IGF2 on CD133 expression and ..
  70. Sohn D, Peters D, Piekorz R, Budach W, Jänicke R. miR-30e controls DNA damage-induced stress responses by modulating expression of the CDK inhibitor p21WAF1/CIP1 and caspase-3. Oncotarget. 2016;7:15915-29 pubmed publisher
    ..Several miRNAs including miR-30e were found upregulated in a p53-dependent manner specifically in senescent cells, but not in apoptotic cells...
  71. Hochfeld L, Anhalt T, Reinbold C, Herrera Rivero M, Fricker N, Nothen M, et al. Expression profiling and bioinformatic analyses suggest new target genes and pathways for human hair follicle related microRNAs. BMC Dermatol. 2017;17:3 pubmed publisher
    ..Expression in the human HF was confirmed for seven of the ten candidate miRNAs, and numerous target genes for miR-24, miR-31, and miR-106a were identified...
  72. Zaccagnini G, Maimone B, Fuschi P, Maselli D, Spinetti G, Gaetano C, et al. Overexpression of miR-210 and its significance in ischemic tissue damage. Sci Rep. 2017;7:9563 pubmed publisher
    Hypoxia-induced miR-210 displays a pro-survival, cytoprotective and pro-angiogenic role in several in vitro systems. In vivo, we previously found that miR-210 inhibition increases ischemic damage...
  73. Wang L, Qu J, Zhou L, Liao F, Wang J. MicroRNA-373 Inhibits Cell Proliferation and Invasion via Targeting BRF2 in Human Non-small Cell Lung Cancer A549 Cell Line. Cancer Res Treat. 2017;: pubmed publisher
    The purpose of this study was to investigate the biological role and mechanism of miR-373 targeting of TFIIB-related factor 2 (BRF2) in the regulation of non-small cell lung cancer (NSCLC) cells.
  74. Ling X, Yao D, Kang L, Zhou J, Zhou Y, Dong H, et al. Involment of RAS/ERK1/2 signaling and MEF2C in miR-155-3p inhibition-triggered cardiomyocyte differentiation of embryonic stem cell. Oncotarget. 2017;8:84403-84416 pubmed publisher
    ..Growing evidence indicates that miR-155 expression changes with the development of heart and plays an important role in heart physiopathology...
  75. Geiger A, Walker A, Nissen E. Human fibrocyte-derived exosomes accelerate wound healing in genetically diabetic mice. Biochem Biophys Res Commun. 2015;467:303-9 pubmed publisher
    ..heat shock protein-90α, total and activated signal transducer and activator of transcription 3, proangiogenic (miR-126, miR-130a, miR-132) and anti-inflammatory (miR124a, miR-125b) microRNAs, and a microRNA regulating collagen ..
  76. Cosar E, Mamillapalli R, Ersoy G, Cho S, Seifer B, Taylor H. Serum microRNAs as diagnostic markers of endometriosis: a comprehensive array-based analysis. Fertil Steril. 2016;106:402-9 pubmed publisher
    ..Receiver operating characteristic (ROC) analysis was performed on differentially expressed miRNAs. miR-3613-5p, miR-6755-3p were down-regulated and miR-125b-5p, miR-150-5p, miR-342-3p, miR-143-3p, miR-145-5p, miR-500a-..
  77. Li X, He S, Li R, Zhou X, Zhang S, Yu M, et al. Pseudomonas aeruginosa infection augments inflammation through miR-301b repression of c-Myb-mediated immune activation and infiltration. Nat Microbiol. 2016;1:16132 pubmed publisher
    ..Here, we report that miR-301b augments pro-inflammatory response during pulmonary infection, and caffeine suppresses the effect of miR-301b ..
  78. Shi X, Wang H, Kong F, Xu Q, Xiao F, Yang Y, et al. Exosomal miR-486 regulates hypoxia-induced erythroid differentiation of erythroleukemia cells through targeting Sirt1. Exp Cell Res. 2017;351:74-81 pubmed publisher
    ..In this study, we identified that miR-486 was a rapid response miRNA to hypoxia in erythroleukemia TF-1 cells...
  79. Jacenik D, Cygankiewicz A, Fichna J, Mokrowiecka A, Małecka Panas E, Krajewska W. Estrogen signaling deregulation related with local immune response modulation in irritable bowel syndrome. Mol Cell Endocrinol. 2018;471:89-96 pubmed publisher
    ..In all studied IBS samples disturbances in expression of cytokines IL-6, IL-10 and TNF-? as well as miR-145, miR-148-5p and miR-592 were observed. This research reveals the association of estrogen receptors with IBS...
  80. Belaya Z, Grebennikova T, Melnichenko G, Nikitin A, Solodovnikov A, Brovkina O, et al. Effects of endogenous hypercortisolism on bone mRNA and microRNA expression in humans. Osteoporos Int. 2018;29:211-221 pubmed publisher
    ..function through the upregulation of Wnt-signaling antagonists (sclerostin, Dkk1) and changes in microRNAs levels (miR-125b-5p, miR-218-5p, miR-34a-5p, miR-188-3p, miR-199a-5p) which are associated with mesenchymal stem-cell ..
  81. Ashraf U, Zhu B, Ye J, Wan S, Nie Y, Chen Z, et al. MicroRNA-19b-3p Modulates Japanese Encephalitis Virus-Mediated Inflammation via Targeting RNF11. J Virol. 2016;90:4780-4795 pubmed publisher
    ..Here, we found the involvement of miR-19b-3p in regulating the JEV-induced inflammatory responsein vitroandin vivo The data demonstrated that miR-19b-3p ..
  82. Yang J, Yang J, Li C, Cui Z, Liu H, Sun X, et al. Downregulation of ZMYND11 induced by miR-196a-5p promotes the progression and growth of GBM. Biochem Biophys Res Commun. 2017;494:674-680 pubmed publisher
    ..Moreover, we explored that ZMYND11 was a new direct and functional target of miR-196a-5p in U87 via luciferase reporter assay...
  83. Kotaki R, Kotani A. A single miRNA complements transcription factor deficiency through the TGF pathway at time of B-cell lineage determination. Rinsho Ketsueki. 2017;58:792-797 pubmed publisher
    ..b>miR-126 induced B-cell differentiation in MLL-AF4 acute lymphoblastic leukemia (ALL) without upregulation of TCF3/E2A, ..
  84. Kim K, Lee T, Cho E. SH3BP4, a novel pigmentation gene, is inversely regulated by miR-125b and MITF. Exp Mol Med. 2017;49:e367 pubmed publisher
    Our previous work has identified miR-125b as a negative regulator of melanogenesis. However, the specific melanogenesis-related genes targeted by this miRNA had not been identified...
  85. Mei H, Zhou M, Zhang X, Huang X, Wang Y, Wang P, et al. Effects of miR-338 on morphine tolerance by targeting CXCR4 in a rat model of bone cancer pain. Biosci Rep. 2017;37: pubmed publisher
    The present study aimed to investigate the effects of miR-338 on morphine tolerance through the targeting of CXC chemokine receptor-4 (CXCR4) in a rat model of bone cancer pain (BCP)...
  86. Hu B, Zhang H, Wang Z, Zhang F, Wei H, Li L. LncRNA CCAT1/miR-130a-3p axis increases cisplatin resistance in non-small-cell lung cancer cell line by targeting SOX4. Cancer Biol Ther. 2017;18:974-983 pubmed publisher
    ..qRT-PCR was performed to detect the expression levels of CCAT, miR-130a-3p, or sex-determining region Y-box 4 (SOX4) mRNA...
  87. Lan F, Qing Q, Pan Q, Hu M, Yu H, Yue X. Serum exosomal miR-301a as a potential diagnostic and prognostic biomarker for human glioma. Cell Oncol (Dordr). 2018;41:25-33 pubmed publisher
    ..The aim of this study was to determine the diagnostic/prognostic significance of serum exosomal miR-301a in glioma patients...
  88. Wa Q, Li L, Lin H, Peng X, Ren D, Huang Y, et al. Downregulation of miR?19a?3p promotes invasion, migration and bone metastasis via activating TGF?? signaling in prostate cancer. Oncol Rep. 2018;39:81-90 pubmed publisher
    ..Here, we report that miR?19a?3p is downregulated in bone metastatic PCa tissues and cells...
  89. Zhao K, Wang Q, Wang Y, Huang K, Yang C, Li Y, et al. EGFR/c-myc axis regulates TGFβ/Hippo/Notch pathway via epigenetic silencing miR-524 in gliomas. Cancer Lett. 2017;406:12-21 pubmed publisher
    ..MicroRNAs (miRNAs) are recognized to participate in gene expression regulation. We found that miR-524-3p and miR-524-5p were suppressed in the classical molecular subtype of glioblastoma (GBM) from Chinese Glioma ..
  90. Ji H, Xiong Y, Song W, Zhang E, Gao Z, Yao F, et al. MicroRNA-28 potentially regulates the photoreceptor lineage commitment of Müller glia-derived progenitors. Sci Rep. 2017;7:11374 pubmed publisher
    ..and Pictar bioinformatics, gain/loss-of-function models, dual luciferase assay, we identified and validated that miR-28 targeted the photoreceptor-specific CRX transcription factor...
  91. Ye Y, Li Z, Feng Q, Chen Z, Wu Z, Wang J, et al. Downregulation of microRNA-145 may contribute to liver fibrosis in biliary atresia by targeting ADD3. PLoS ONE. 2017;12:e0180896 pubmed publisher
    ..ADD3 and microRNA-145 (miR-145) expression profiles in liver tissues of BA and CC were determined using qPCR...
  92. Liu J, Fei D, Xing J, Du J. MicroRNA-29a inhibits proliferation and induces apoptosis in rheumatoid arthritis fibroblast-like synoviocytes by repressing STAT3. Biomed Pharmacother. 2017;96:173-181 pubmed publisher
    ..In this study, we explored the biological function and underlying mechanism of microRNA-29a (miR-29a) in cultured RA-FLS from RA patients...