MARCH8

Summary

Gene Symbol: MARCH8
Description: membrane associated ring-CH-type finger 8
Alias: CMIR, MARCH-VIII, MIR, RNF178, c-MIR, E3 ubiquitin-protein ligase MARCH8, RING finger protein 178, RING-type E3 ubiquitin transferase MARCH8, c-mir, cellular modulator of immune recognition, cellular modulator of immune recognition (c-MIR), membrane associated ring finger 8, membrane-associated RING finger protein 8, membrane-associated RING-CH protein VIII, membrane-associated ring finger (C3HC4) 8, E3 ubiquitin protein ligase
Species: human
Products:     MARCH8

Top Publications

  1. Goto E, Ishido S, Sato Y, Ohgimoto S, Ohgimoto K, Nagano Fujii M, et al. c-MIR, a human E3 ubiquitin ligase, is a functional homolog of herpesvirus proteins MIR1 and MIR2 and has similar activity. J Biol Chem. 2003;278:14657-68 pubmed
    Kaposi's sarcoma associated-herpes virus encodes two proteins, MIR (modulator of immune recognition) 1 and 2, which are involved in the evasion of host immunity...
  2. Eyster C, Cole N, Petersen S, Viswanathan K, Fruh K, Donaldson J. MARCH ubiquitin ligases alter the itinerary of clathrin-independent cargo from recycling to degradation. Mol Biol Cell. 2011;22:3218-30 pubmed publisher
    ..Expression of the membrane-associated RING-CH 8 (MARCH8) E3 ubiquitin ligase completely shifted the trafficking of CD44 and CD98 proteins away from recycling tubules to ..
  3. Bartee E, Mansouri M, Hovey Nerenberg B, Gouveia K, Fruh K. Downregulation of major histocompatibility complex class I by human ubiquitin ligases related to viral immune evasion proteins. J Virol. 2004;78:1109-20 pubmed
  4. Lapaque N, Jahnke M, Trowsdale J, Kelly A. The HLA-DRalpha chain is modified by polyubiquitination. J Biol Chem. 2009;284:7007-16 pubmed publisher
    ..Two E3 ligases, MARCH I and MARCH VIII, have been shown to polyubiquitinate lysine residue 225 in the cytoplasmic tail of I-Abeta and HLA-DRbeta...
  5. Bartee E, Eyster C, Viswanathan K, Mansouri M, Donaldson J, Fruh K. Membrane-Associated RING-CH proteins associate with Bap31 and target CD81 and CD44 to lysosomes. PLoS ONE. 2010;5:e15132 pubmed publisher
    ..Our data thus suggest a role of MARCH-VIII and MARCH-IV in the regulated turnover of CD81 and CD44, two ubiquitously expressed, multifunctional proteins. ..
  6. Chen R, Li M, Zhang Y, Zhou Q, Shu H. The E3 ubiquitin ligase MARCH8 negatively regulates IL-1?-induced NF-?B activation by targeting the IL1RAP coreceptor for ubiquitination and degradation. Proc Natl Acad Sci U S A. 2012;109:14128-33 pubmed publisher
    ..Here, we identified the E3 ubiquitin ligase membrane-associated RING-CH (MARCH8) as a suppressor of IL-1?-induced NF-?B- and MAPK-activation pathways...
  7. van de Kooij B, Verbrugge I, de Vries E, Gijsen M, Montserrat V, Maas C, et al. Ubiquitination by the membrane-associated RING-CH-8 (MARCH-8) ligase controls steady-state cell surface expression of tumor necrosis factor-related apoptosis inducing ligand (TRAIL) receptor 1. J Biol Chem. 2013;288:6617-28 pubmed publisher
    ..These findings reveal that endogenous MARCH-8 regulates the steady-state cell surface expression of TRAIL-R1. ..
  8. Fujita H, Iwabu Y, Tokunaga K, Tanaka Y. Membrane-associated RING-CH (MARCH) 8 mediates the ubiquitination and lysosomal degradation of the transferrin receptor. J Cell Sci. 2013;126:2798-809 pubmed publisher
    ..Similar to other RING-type ubiquitin ligases, the RING-CH domain of MARCH8, which is located in the N-terminal cytoplasmic domain, is essential for the ubiquitination and downregulation of ..
  9. Tutar Y. miRNA and cancer; computational and experimental approaches. Curr Pharm Biotechnol. 2014;15:429 pubmed
    ..Dr. Vasconcelos showed that overexpression of miR-128 decreased acute myeloid leukemia cells and increased the DNA damage...

More Information

Publications143 found, 100 shown here

  1. Kiang J, Smith J, Anderson M, Elliott T, Gupta P, Balakathiresan N, et al. Hemorrhage enhances cytokine, complement component 3, and caspase-3, and regulates microRNAs associated with intestinal damage after whole-body gamma-irradiation in combined injury. PLoS ONE. 2017;12:e0184393 pubmed publisher
    ..Among the altered miRNAs, CI increased miR-34 in the serum and ileum which targeted an increased phosphorylation of ERK, p38, and increased NF-?B, thereby ..
  2. Lim E, Lim J, Kim E, Kim Y, Shin J, Seok P, et al. Xylobiose, an Alternative Sweetener, Ameliorates Diabetes-Related Metabolic Changes by Regulating Hepatic Lipogenesis and miR-122a/33a in db/db Mice. Nutrients. 2016;8: pubmed
    ..The expression levels of miR-122a and miR-33a were higher and lower in the XB group, respectively...
  3. Murata M. Inflammation and cancer. Environ Health Prev Med. 2018;23:50 pubmed publisher
    ..Quantitative RT-PCR analysis confirmed the concordant downregulation of miR-497 in cancer tissues and plasma, suggesting that plasma miR-497 could be used as a diagnostic biomarker for ..
  4. Erice O, Munoz Garrido P, Vaquero J, Perugorria M, Fernández Barrena M, Saez E, et al. MicroRNA-506 promotes primary biliary cholangitis-like features in cholangiocytes and immune activation. Hepatology. 2018;67:1420-1440 pubmed publisher
    ..MicroRNA (miR) dysregulation occurs in liver and immune cells of PBC patients, but its functional relevance is largely unknown...
  5. Mazzio E, Soliman K. HTP Nutraceutical Screening for Histone Deacetylase Inhibitors and Effects of HDACis on Tumor-suppressing miRNAs by Trichostatin A and Grapeseed (Vitis vinifera) in HeLa cells. Cancer Genomics Proteomics. 2017;14:17-33 pubmed
    ..g. hsa-miR-23b-5p, hsa-miR-27b-5p, hsa-miR-1180-3p, hsa-miR-6880-5p and hsa-mir-943)...
  6. Zou H, Wang Y, Gang Q, Zhang Y, Sun Y. Plasma level of miR-93 is associated with higher risk to develop type 2 diabetic retinopathy. Graefes Arch Clin Exp Ophthalmol. 2017;255:1159-1166 pubmed publisher
    MicroRNA-93 (miR-93) usually acts as a promoter of tumor progression in several human carcinomas. It has been found distinctly high in eyes with proliferative diabetic retinopathy (DR)...
  7. Bhatia H, Pattnaik B, Datta M. Inhibition of mitochondrial β-oxidation by miR-107 promotes hepatic lipid accumulation and impairs glucose tolerance in vivo. Int J Obes (Lond). 2016;40:861-9 pubmed publisher
    ..In our previous study, we had demonstrated that fatty acid synthase (FASN) is a target of miR-107...
  8. Huang Y, Yang Y, Huang F, Tiao M, Lin Y, Tsai M, et al. MicroRNA-29a mitigation of endoplasmic reticulum and autophagy aberrance counteracts in obstructive jaundice-induced fibrosis in mice. Exp Biol Med (Maywood). 2017;:1535370217741500 pubmed publisher
    ..We have previously shown that microRNA-29a (miR-29a) protects against liver fibrosis...
  9. Bhattacharjya S, Roy K, Ganguly A, Sarkar S, Panda C, Bhattacharyya D, et al. Inhibition of nucleoporin member Nup214 expression by miR-133b perturbs mitotic timing and leads to cell death. Mol Cancer. 2015;14:42 pubmed publisher
    ..Databases/bioinformatic tools such as miRBase, Oncomine and RNAhybrid predicted Nup214 as a miR-133b target. To validate this, we used luciferase reporter assays, Real-Time PCR and immuno-blotting...
  10. Zheng Y, Jiang S, Zhang Y, Zhang R, Gong D. Detection of miR-33 Expression and the Verification of Its Target Genes in the Fatty Liver of Geese. Int J Mol Sci. 2015;16:12737-52 pubmed publisher
    ..The examination of miR-33 expression and its target genes can promote the in-depth study of the miRNA regulation mechanism in the ..
  11. Chen H, Zhao J, Li Y, He L, Huang Y, Shu W, et al. Gene expression network regulated by DNA methylation and microRNA during microcystin-leucine arginine induced malignant transformation in human hepatocyte L02 cells. Toxicol Lett. 2018;289:42-53 pubmed publisher
    ..MiRNA-mRNA network and mRNA-mRNA network analysis showed that hsa-miR-320a, hsa-miR-331-3p, hsa-miR-26a-5p, hsa-miR-196a-5p, hsa-miR-221-3p, coiled-coil domain containing 180 (CCDC180), ..
  12. Smith J, Jeng S, McWeeney S, Hirsch A. A MicroRNA Screen Identifies the Wnt Signaling Pathway as a Regulator of the Interferon Response during Flavivirus Infection. J Virol. 2017;91: pubmed publisher
    ..Several families of miRNAs were identified as inhibiting multiple flaviviruses, including the miRNA miR-34, miR-15, and miR-517 families...
  13. Jia K, Pan S, Ding H, Liu J, Zheng Y, Wang S, et al. Chaihu-shugan san inhibits inflammatory response to improve insulin signaling in liver and prefrontal cortex of CUMS rats with glucose intolerance. Biomed Pharmacother. 2018;103:1415-1428 pubmed publisher
    ..RT-qPCR and Western blot analysis, as well as microRNA-155 (miR-155) mimic or inhibitor transfection were used to explore possible association of MyD88 and miR-155...
  14. Liu M, Liu R, Wu H, Li Y, Su M, Dong M, et al. Radix puerariae extracts ameliorate paraquat-induced pulmonary fibrosis by attenuating follistatin-like 1 and nuclear factor erythroid 2p45-related factor-2 signalling pathways through downregulation of miRNA-21 expression. BMC Complement Altern Med. 2016;16:11 pubmed publisher
    ..We examined effects of miR-21 on follistatin-like 1 (Fstl 1) pathways and oxidative stress in the lung...
  15. Kodo K, Sugimoto S, Nakajima H, Mori J, Itoh I, Fukuhara S, et al. Erythropoietin (EPO) ameliorates obesity and glucose homeostasis by promoting thermogenesis and endocrine function of classical brown adipose tissue (BAT) in diet-induced obese mice. PLoS ONE. 2017;12:e0173661 pubmed publisher
    ..EPO's suppression of myocyte enhancer factor 2c (Mef2c) and microRNA-133a (miR-133a) via ?3-adrenergic receptor caused PRDM16 upregulation...
  16. Janaki Ramaiah M, Lavanya A, Honarpisheh M, Zarea M, Bhadra U, Bhadra M. MiR-15/16 complex targets p70S6 kinase 1 and controls cell proliferation in MDA-MB-231 breast cancer cells. Gene. 2014;552:255-64 pubmed publisher
    ..To have a better insight of the role of miR-15/16 in regulating the cross talk of p53 and mTOR, we performed an in depth study in MDA-MB-231 breast cancer ..
  17. Satishchandran A, Ambade A, Rao S, Hsueh Y, Iracheta Vellve A, Tornai D, et al. MicroRNA 122, Regulated by GRLH2, Protects Livers of Mice and Patients From Ethanol-Induced Liver Disease. Gastroenterology. 2018;154:238-252.e7 pubmed publisher
    ..and controls, were given injections of recombinant adeno-associated virus 8 vector that expressed the primary miR-122 transcript (pri-MIR122, to overexpress MIR122 in hepatocytes) or vector (control)...
  18. Henshall D, Hamer H, Pasterkamp R, Goldstein D, Kjems J, Prehn J, et al. MicroRNAs in epilepsy: pathophysiology and clinical utility. Lancet Neurol. 2016;15:1368-1376 pubmed publisher
    ..Early functional studies showed that silencing of brain-specific miR-134 using antisense oligonucleotides (antagomirs) had potent antiseizure effects in animal models, whereas genetic ..
  19. Chen D, Dixon B, Doycheva D, Li B, Zhang Y, Hu Q, et al. IRE1? inhibition decreased TXNIP/NLRP3 inflammasome activation through miR-17-5p after neonatal hypoxic-ischemic brain injury in rats. J Neuroinflammation. 2018;15:32 pubmed publisher
    ..In the present study, we sought to investigate whether microRNA-17 (miR-17), a potential IRE1? ribonuclease (RNase) substrate, arbitrates downregulation of thioredoxin-interacting protein ..
  20. Liu D, Han L, Wu X, Yang X, Zhang Q, Jiang F. Genome-wide microRNA changes in human intracranial aneurysms. BMC Neurol. 2014;14:188 pubmed publisher
    ..The changed microRNAs included endothelium-enriched microRNAs such as members of the let-7 family, miR-17, miR-23b, miR-126, hsa-miR-24-1 and miR-222, and vascular smooth muscle-enriched miRNAs such as miR-143 and miR-..
  21. Kuwano Y, Nishida K, Kajita K, Satake Y, Akaike Y, Fujita K, et al. Transformer 2β and miR-204 regulate apoptosis through competitive binding to 3' UTR of BCL2 mRNA. Cell Death Differ. 2015;22:815-25 pubmed publisher
    ..respectively, showed that Tra2β bound to BCL2α 3' UTR, and that Tra2β knockdown facilitated association of miR-204 with BCL2α 3' UTR...
  22. Piletič K, Kunej T. MicroRNA epigenetic signatures in human disease. Arch Toxicol. 2016;90:2405-19 pubmed publisher
    ..The review revealed that hsa-miR-34a, hsa-miR-34b, and hsa-miR-34c are the most frequently reported epigenetically dysregulated miRNAs...
  23. Zhan C, Chen D, Luo J, Shi Y, Zhang Y. Protective role of down-regulated microRNA-31 on intestinal barrier dysfunction through inhibition of NF-κB/HIF-1α pathway by binding to HMOX1 in rats with sepsis. Mol Med. 2018;24:55 pubmed publisher
    ..Herein, we evaluate the effect of microRNA-31 (miR-31) on intestinal barrier dysfunction through NF-κB/HIF-1α pathway by targeting HMOX1 in rats with sepsis...
  24. Pérez García A, Dongil P, Hurtado Carneiro V, Blazquez E, Sanz C, Alvarez E. High-fat diet alters PAS kinase regulation by fasting and feeding in liver. J Nutr Biochem. 2018;57:14-25 pubmed publisher
    ..The expression of miR-33a and miR-143 changes in PASK-deficient mice with an HFD...
  25. Qureshi A, Khan D, Mushtaq S, Ye S, Xiong M, Qureshi N. ?-Tocotrienol feeding modulates gene expression of EIF2, mTOR, protein ubiquitination through multiple-signaling pathways in chronic hepatitis C patients. Lipids Health Dis. 2018;17:167 pubmed publisher
    ..regulators (85) were involved with cAMP, STAT2, 26S proteasome, CSF1, IFN?, LDL, TGFA, and microRNA-155-5p, miR-223, miR-21-5p...
  26. Yang Z, Wang Y, Jia B, Mao G, Lv Y, Wang G, et al. Downregulation of miR-146a, cyclooxygenase-2 and advanced glycation end-products in simvastatin-treated older patients with hyperlipidemia. Geriatr Gerontol Int. 2016;16:322-8 pubmed publisher
    ..We tested miR-146a, interleukin-1-receptor-associated kinase 1, tumor necrosis factor-receptor-associated factor 6 ..
  27. Xu D, Ma P, Gao G, Gui Y, Niu X, Jin B. MicroRNA-383 expression regulates proliferation, migration, invasion, and apoptosis in human glioma cells. Tumour Biol. 2015;36:7743-53 pubmed publisher
    This study aims to evaluate microRNA-383 (miR-383) expression level in glioma cells and its influences on proliferation, migration, invasion, apoptosis, and cell cycle in glioma cells...
  28. Liu X, Shi H, Liu B, Li J, Liu Y, Yu B. miR-330-3p controls cell proliferation by targeting early growth response 2 in non-small-cell lung cancer. Acta Biochim Biophys Sin (Shanghai). 2015;47:431-40 pubmed publisher
    ..Recent studies have indicated that miR-330-3p expression is up-regulated in NSCLC samples and in tissues of NSCLC brain metastasis...
  29. Yu Y, Zhang J, Zhang B. MicroRNA-135b exerts oncogenic activity in glioblastoma via the inhibition of glycerol kinase 5 expression. Mol Med Rep. 2015;12:2721-6 pubmed publisher
    ..The regulatory mechanism of GK5 in glioblastoma were also investigated. It was revealed that GK5 is a target of miR-135b in U87MG glioblastoma cells...
  30. Leti F, Malenica I, Doshi M, Courtright A, Van Keuren Jensen K, Legendre C, et al. High-throughput sequencing reveals altered expression of hepatic microRNAs in nonalcoholic fatty liver disease-related fibrosis. Transl Res. 2015;166:304-14 pubmed publisher
    ..box O3 and F-box WD repeat domain containing 7, E3 ubiquitin protein ligase (FBXW7) as potential targets of miR-182, and found that levels of forkhead box O3, but not FBXW7, were significantly decreased in fibrotic samples...
  31. Wu G, Yang G, Zhang R, Xu G, Zhang L, Wen W, et al. Altered microRNA Expression Profiles of Extracellular Vesicles in Nasal Mucus From Patients With Allergic Rhinitis. Allergy Asthma Immunol Res. 2015;7:449-57 pubmed publisher
    ..Furthermore, miR-30-5p, miR-199b-3p, miR-874, miR-28-3p, miR-203, and miR-875-5p, involved in B-cell receptor and salivary secretion ..
  32. Zhao Y, Li F, Zhang X, Liu A, Qi J, Cui H, et al. MicroRNA-194 acts as a prognostic marker and inhibits proliferation in hepatocellular carcinoma by targeting MAP4K4. Int J Clin Exp Pathol. 2015;8:12446-54 pubmed
    ..In this study, we aimed to analyze the role of microRNA-194 (miR-194) in HCC...
  33. Pang C, Liu M, Fang W, Guo J, Zhang Z, Wu P, et al. MiR-139-5p is Increased in the Peripheral Blood of Patients with Prostate Cancer. Cell Physiol Biochem. 2016;39:1111-7 pubmed publisher
    ..Aberrant expression of miRNA (miR)-139-5p has been observed in various types of cancers...
  34. Zhang J, CHEN J, Hua L, Yao K, Wang C. miR-98 inhibits hepatocellular carcinoma cell proliferation via targeting EZH2 and suppressing Wnt/?-catenin signaling pathway. Biomed Pharmacother. 2017;85:472-478 pubmed publisher
    ..In the current study, we explore the function of miR-98 in HCC cell proliferation...
  35. Penfornis P, Fernandes J, Pochampally R. Polycomb group protein Suz12 is regulated by a novel miRNA-like small RNA. Sci Rep. 2018;8:1720 pubmed publisher
    ..on deep-sequencing of small RNA from EVs of MSCs, we now report the characterization of novel small RNA, named n-miR-G665, which exhibits typical properties of miRNAs...
  36. Liu W, Bi P, Shan T, Yang X, Yin H, Wang Y, et al. miR-133a regulates adipocyte browning in vivo. PLoS Genet. 2013;9:e1003626 pubmed publisher
    ..Here we show that miR-133a, a microRNA that is expressed in both BAT and SATs, directly targets the 3' UTR of Prdm16...
  37. Yu L, Jin R, Gu P, Ling Z, Lin X, Du J. Clinical significance of microRNA-130b in osteosarcoma and in cell growth and invasion. Asian Pac J Trop Med. 2015;8:752-6 pubmed publisher
    To investigate clinical significance of microRNA-130b (miR-130b) in osteosarcoma and its role in cell growth and invasion...
  38. Sun Y, Yu X, Bai Q. miR-204 inhibits invasion and epithelial-mesenchymal transition by targeting FOXM1 in esophageal cancer. Int J Clin Exp Pathol. 2015;8:12775-83 pubmed
    ..Deregulation of microRNA-204 (miR-204) has been documented in many cancers, but its role in the development of esophageal cancer (EC) has not been ..
  39. Lu W, Lu T, Wei X. Downregulation of DNMT3a expression increases miR-182-induced apoptosis of ovarian cancer through caspase-3 and caspase-9-mediated apoptosis and DNA damage response. Oncol Rep. 2016;36:3597-3604 pubmed publisher
    ..In the ovarian cancer tissues, DNMT3a expression was upregulated and miR-182 expression was downregulated...
  40. Wilson R, Espinosa Díez C, Kanner N, Chatterjee N, Ruhl R, Hipfinger C, et al. MicroRNA regulation of endothelial TREX1 reprograms the tumour microenvironment. Nat Commun. 2016;7:13597 pubmed publisher
    ..Using gain-and-loss of function approaches, we show that miR-103 exacerbates DNA damage and inhibits angiogenesis in vitro and in vivo...
  41. Merrigan S, Kennedy B. Vitamin D receptor agonists regulate ocular developmental angiogenesis and modulate expression of dre-miR-21 and VEGF. Br J Pharmacol. 2017;174:2636-2651 pubmed publisher
    ..Calcitriol induced a three to sevenfold increase in ocular dre-miR-21 expression...
  42. Gu Y, Zhang Z, Yin J, Ye J, Song Y, Liu H, et al. Epigenetic silencing of miR-493 increases the resistance to cisplatin in lung cancer by targeting tongue cancer resistance-related protein 1(TCRP1). J Exp Clin Cancer Res. 2017;36:114 pubmed publisher
    ..Real-time quantitative PCR (qRT-PCR) and In situ hybridization (ISH) were used to analyze the expression of miR-493 in lung cancer cell lines and tumor tissue, respectively...
  43. Zheng C, Zheng Z, Sun J, Zhang Y, Wei C, Ke X, et al. MiR-16-5p mediates a positive feedback loop in EV71-induced apoptosis and suppresses virus replication. Sci Rep. 2017;7:16422 pubmed publisher
    ..We previously reported that miR-16-5p increases with severity of HFMD by investigating the expression patterns of host miRNAs in patients with HFMD...
  44. Shen X, Guo Y, Yu J, Qi J, Shi W, Wu X, et al. miRNA-202 in bone marrow stromal cells affects the growth and adhesion of multiple myeloma cells by regulating B cell-activating factor. Clin Exp Med. 2016;16:307-16 pubmed publisher
    ..In this study, we characterized the role of miR-202 in regulating the expression of BAFF in BMSCs...
  45. Gao S, Wang J, Xie J, Zhang T, Dong P. Role of miR-138 in the regulation of larynx carcinoma cell metastases. Tumour Biol. 2015;: pubmed
    ..Here, we studied the LC specimens from the patients and found that the levels of miR-138 were significantly decreased and the levels of ZEB2, a critical factor that regulates cancer cell invasiveness, ..
  46. Wu K, Zhao Z, Ma J, Chen J, Peng J, Yang S, et al. Deregulation of miR-193b affects the growth of colon cancer cells via transforming growth factor-? and regulation of the SMAD3 pathway. Oncol Lett. 2017;13:2557-2562 pubmed publisher
    ..The results of the present study suggested that the deregulation of miRNA-193b may affect cell growth in colon cancer via the TGF-? and SMAD3 signaling pathways. ..
  47. Wang Z, Yang J, Di J, Cui M, Xing J, Wu F, et al. Downregulated USP3 mRNA functions as a competitive endogenous RNA of SMAD4 by sponging miR-224 and promotes metastasis in colorectal cancer. Sci Rep. 2017;7:4281 pubmed publisher
    ..USP3 and SMAD4 were directly targeted by miR-224, and overexpression of the USP3 3'UTR could inhibit metastasis caused by the loss of USP3...
  48. Chang M, Park S, Choi J, Kim Y, Suh M, Lee J, et al. MicroRNAs 218a-5p, 219a-5p, and 221-3p regulate vestibular compensation. Sci Rep. 2017;7:8701 pubmed publisher
    ..Administration of miR-218a-5p, 219a-5p, and 221-3p oligomers significantly affected vestibular compensation...
  49. Geletina N, Kobelev V, Babayants E, Feng L, Pustylnyak V, Gulyaeva L. PTEN negative correlates with miR-181a in tumour tissues of non-obese endometrial cancer patients. Gene. 2018;655:20-24 pubmed publisher
    ..Our study investigated and analysed the expression levels of PTEN and PTEN-targeting miR-21, miR-181a, miR-214, miR-301a, and miR-1908 in total of 78 samples, out of which 26 samples were from normal ..
  50. Ventura S, Aryee D, Felicetti F, De Feo A, Mancarella C, Manara M, et al. CD99 regulates neural differentiation of Ewing sarcoma cells through miR-34a-Notch-mediated control of NF-κB signaling. Oncogene. 2016;35:3944-54 pubmed publisher
    ..NF-κB inhibition passes through miR-34a-mediated repression of Notch pathway...
  51. Jin Y, Zhang F, Ma Z, Ren Z. MicroRNA 433 regulates nonsense-mediated mRNA decay by targeting SMG5 mRNA. BMC Mol Biol. 2016;17:17 pubmed publisher
    ..The present study demonstrated that miR-433 was involved in NMD pathway via negatively regulating SMG5...
  52. Zawada A, Zhang L, Emrich I, Rogacev K, Krezdorn N, Rotter B, et al. MicroRNA profiling of human intermediate monocytes. Immunobiology. 2017;222:587-596 pubmed publisher
    ..to both classical and non-classical monocytes with a p value of <10-10, of which two miRNAs - miR-6087 (upregulated) and miR-150-5p (downregulated) - differed in their expression more than ten-fold...
  53. Yang H, Ju F, Guo X, Ma S, Wang L, Cheng B, et al. RNA-binding protein RBM3 prevents NO-induced apoptosis in human neuroblastoma cells by modulating p38 signaling and miR-143. Sci Rep. 2017;7:41738 pubmed publisher
    ..Furthermore, both RBM3 overexpression and mild hypothermia abolished the induction of miR-143 by NO, which was shown to mediate the cytotoxicity of NO in a p38-dependent way...
  54. Liu D, Tang H, Li X, Deng M, Wei N, Wang X, et al. Targeting the HDAC2/HNF-4A/miR-101b/AMPK Pathway Rescues Tauopathy and Dendritic Abnormalities in Alzheimer's Disease. Mol Ther. 2017;25:752-764 pubmed publisher
    ..of the hepatocyte nuclear factor 4α (HNF-4A) transcription factor, which disrupted its binding to the miR-101b promoter...
  55. Zhou Y, Hao Y, Li Y, Li R, Wu R, Wang S, et al. Amplification and up-regulation of MIR30D was associated with disease progression of cervical squamous cell carcinomas. BMC Cancer. 2017;17:230 pubmed publisher
    Cervical squamous cell carcinoma (CSCC) is the most frequent type among cervical cancers. Although the altered miRNA miR-30d expression and the amplified chromosome locus of MIR30D, 8q24, have been reported in somatic cancers, the ..
  56. Yndestad S, Austreid E, Skaftnesmo K, Lønning P, Eikesdal H. Divergent Activity of the Pseudogene PTENP1 in ER-Positive and Negative Breast Cancer. Mol Cancer Res. 2018;16:78-89 pubmed publisher
    ..decreases ERα (ESR1) mRNA and protein levels in MCF7 xenografts with a concomitant increase in hsa-miR-26a, a miRNA known to target ESR1 In the ER-negative MDA-MB-231 and C3HBA breast cancer cells, upregulation ..
  57. Shi W, Yang J, Li S, Shan X, Liu X, Hua H, et al. Potential involvement of miR-375 in the premalignant progression of oral squamous cell carcinoma mediated via transcription factor KLF5. Oncotarget. 2015;6:40172-85 pubmed publisher
    ..We demonstrate the involvement of a suppressive microRNA, miR-375, in the regulation of this premalignant progression via KLF5, a transcription factor that modulates the ..
  58. Zhang B, Chen C, Wang A, Lin Q. MiR-16 regulates cell death in Alzheimer's disease by targeting amyloid precursor protein. Eur Rev Med Pharmacol Sci. 2015;19:4020-7 pubmed
    The aim of this study was to investigate the role of miR-16 in Alzheimer's disease (AD) and to explore its mechanism of action...
  59. Jing P, Sa N, Xu W. [miR-140-5p affects the migration and invasion of hypopharyngeal carcinoma cells by downregulating ADAM10 expression]. Zhonghua Er Bi Yan Hou Tou Jing Wai Ke Za Zhi. 2016;51:189-96 pubmed publisher
    To investigate the expression of miR-140-5p and ADAM10 in hypopharyngeal carcinoma tissues and their effects on the migration and invasion of FaDu cells and underlying mechanism...
  60. Wang Q, Selth L, Callen D. MiR-766 induces p53 accumulation and G2/M arrest by directly targeting MDM4. Oncotarget. 2017;8:29914-29924 pubmed publisher
    ..In the present study, we found that the microRNA miR-766 was aberrantly expressed in breast cancer, and that over-expression of miR-766 caused accumulation of wild-type ..
  61. Ye Z, Fang B, Pan J, Zhang N, Huang J, Xie C, et al. miR-138 suppresses the proliferation, metastasis and autophagy of non-small cell lung cancer by targeting Sirt1. Oncol Rep. 2017;37:3244-3252 pubmed publisher
    The present study determined the role and mechanism of miR-138 in non-small cell lung cancer (NSCLC). In total, 45 freshly resected clinical NSCLC tissues were collected...
  62. Khosravi M, Karimi M, Hossein Aghdaie M, Kalani M, Naserian S, Bidmeshkipour A. Mesenchymal stem cells can induce regulatory T cells via modulating miR-126a but not miR-10a. Gene. 2017;627:327-336 pubmed publisher
    ..Here, we assessed the possible effect of MSCs on miR-126a and miR-10a expression in iTregs and, consequently on Foxp3 stability, a regulatory pathway that has not yet ..
  63. Verma J, Rastogi R, Mukhopadhyay A. Leishmania donovani resides in modified early endosomes by upregulating Rab5a expression via the downregulation of miR-494. PLoS Pathog. 2017;13:e1006459 pubmed publisher
    ..the expression of Rab5a by degrading c-Jun via their metalloprotease gp63 to downregulate the expression of miR-494 in THP-1 differentiated human macrophages...
  64. Zeng M, Zhu L, Li L, Kang C. miR-378 suppresses the proliferation, migration and invasion of colon cancer cells by inhibiting SDAD1. Cell Mol Biol Lett. 2017;22:12 pubmed publisher
    ..Our study focuses on the role of miR-378 in colon cancer cells...
  65. Carabia J, Carpio C, Abrisqueta P, Jimenez I, Purroy N, Calpe E, et al. Microenvironment regulates the expression of miR-21 and tumor suppressor genes PTEN, PIAS3 and PDCD4 through ZAP-70 in chronic lymphocytic leukemia. Sci Rep. 2017;7:12262 pubmed publisher
    ..Among proteins participating, ZAP-70 enhances response to microenvironmental stimuli. MicroRNA-21 (miR-21) is overexpressed in diverse neoplasias including CLL, where it has been associated to refractoriness to ..
  66. Fan D, Lin X, Zhang F, Zhong W, Hu J, Chen Y, et al. MicroRNA 26b promotes colorectal cancer metastasis by downregulating phosphatase and tensin homolog and wingless-type MMTV integration site family member 5A. Cancer Sci. 2018;109:354-362 pubmed publisher
    ..Herein we report that ectopic overexpression of microRNA 26b (miR-26b) in colorectal cancer (CRC) cell lines promoted EMT and stem cell-like phenotypes in vitro...
  67. El Samahy M, Adly A, Elhenawy Y, Ismail E, Pessar S, Mowafy M, et al. Urinary miRNA-377 and miRNA-216a as biomarkers of nephropathy and subclinical atherosclerotic risk in pediatric patients with type 1 diabetes. J Diabetes Complications. 2018;32:185-192 pubmed publisher
    ..To identify the expression of urinary miR-377 and miR-216a in 50 children and adolescents with type 1 diabetes (T1DM) compared with 50 healthy controls and ..
  68. He X, Sun Y, Lei N, Fan X, Zhang C, Wang Y, et al. MicroRNA-351 promotes schistosomiasis-induced hepatic fibrosis by targeting the vitamin D receptor. Proc Natl Acad Sci U S A. 2018;115:180-185 pubmed publisher
    ..Here, we showed that the expression of host miR-351 in HSCs was markedly reduced during the early stage of Schistosoma infection...
  69. Zhou W, Liu X, Yang Y, Liu Y. THE INFLUENCE AND REGULATORY MECHANISM OF Y-BOX BINDING PROTEIN 1 IN OSTEOSARCOMA AND ITS SIGNIFICANCE. J Biol Regul Homeost Agents. 2015;29:485-91 pubmed
    ..7%, respectively (p = 0.036), indicating that patients with high YB-1 expression had higher pulmonary metastasis rate. Through further study, we discovered that possibly miR-382 plays a regulatory role in YB-1 gene in osteosarcoma.
  70. Li X, Li K, Wu Z. Association of four common SNPs in microRNA polymorphisms with the risk of hepatocellular carcinoma. Int J Clin Exp Pathol. 2015;8:9560-6 pubmed
    We conducted a case-control study to investigate genetic variants of miR-146a rs2910164, miR-196a2 rs11614913, miR-149 rs2292832 and miR-499 rs3746444 in the development of HCC in a Chinese population...
  71. Liu T, Hu K, Zhao Z, Chen G, Ou X, Zhang H, et al. MicroRNA-1 down-regulates proliferation and migration of breast cancer stem cells by inhibiting the Wnt/β-catenin pathway. Oncotarget. 2015;6:41638-49 pubmed publisher
    ..of breast cancer stem cells (CSCs) and non-CSC tumor cells by miRNA microarray and determined the effect of altered miR-1 expression on proliferation and migration of breast CSCs...
  72. Jinato T, Chuaypen N, Poomipak W, Praianantathavorn K, Makkoch J, Kiatbumrung R, et al. Original Research: Analysis of hepatic microRNA alterations in response to hepatitis B virus infection and pegylated interferon alpha-2a treatment. Exp Biol Med (Maywood). 2016;241:1803-10 pubmed publisher
    ..Results revealed that two down-regulated microRNAs including miR-185-5p and miR-186-5p were correlated in both in vitro and in vivo studies...
  73. Zhou M, Fu J, Xiao L, Yang S, Song Y, Zhang X, et al. miR-196a overexpression activates the MEK/ERK signal and represses the progesterone receptor and decidualization in eutopic endometrium from women with endometriosis. Hum Reprod. 2016;31:2598-2608 pubmed
    ..progesterone receptor (PGR) expression in the eutopic endometrium of women with endometriosis? SUMMARY ANSWER: miR-196a upregulates MEK/ERK signalling, mediating a downregulation of PGR expression in the eutopic endometrium of ..
  74. Wang Y, Li F, Wang S. MicroRNA?93 is overexpressed and induces apoptosis in glaucoma trabecular meshwork cells. Mol Med Rep. 2016;14:5746-5750 pubmed publisher
    ..The present study aimed to reveal the effect of microRNA?93 (miR?93) on glaucoma trabecular meshwork (GTM) cell apoptosis...
  75. Guo Y, Ma X, Wu W, Shi M, Ma J, Zhang Y, et al. Coordinated microRNA/mRNA expression profiles reveal a putative mechanism of corneal epithelial cell transdifferentiation from skin epidermal stem cells. Int J Mol Med. 2017;: pubmed publisher
    ..b>miR?10b exhibited the largest change in expression between the cell types...
  76. Patutina O, Bichenkova E, Miroshnichenko S, Mironova N, Trivoluzzi L, Burusco K, et al. miRNases: Novel peptide-oligonucleotide bioconjugates that silence miR-21 in lymphosarcoma cells. Biomaterials. 2017;122:163-178 pubmed publisher
    ..cleavage and biological relevance of a set of these designed miRNases was assayed with respect to highly oncogenic miR-21. Several miRNases demonstrated effective site-selective cleavage of miR-21 exclusively at G-X bonds...
  77. Hazra B, Kumawat K, Basu A. The host microRNA miR-301a blocks the IRF1-mediated neuronal innate immune response to Japanese encephalitis virus infection. Sci Signal. 2017;10:eaaf5185 pubmed publisher
    ..We showed that the JEV-induced expression of miR-301a led to inhibition of the production of type I IFN by reducing the abundances of the transcription factor ..
  78. Zhao C, Li X, Han B, You Z, Qu L, Liu C, et al. Gga-miR-219b targeting BCL11B suppresses proliferation, migration and invasion of Marek's disease tumor cell MSB1. Sci Rep. 2017;7:4247 pubmed publisher
    ..Previous miRNAome analysis showed gga-miR-219b was significantly downregulated in MDV-induced lymphoma, and one of its potential target genes, B-cell chronic ..
  79. Zhou C, Jiang C, Zong Z, Lin J, Lao L. miR-146a promotes growth of osteosarcoma cells by targeting ZNRF3/GSK-3?/?-catenin signaling pathway. Oncotarget. 2017;8:74276-74286 pubmed publisher
    MicroRNA-146a-5p (miR-146a) functions as a tumor suppressor or oncogene involved in multiple biological processes. But, the underlying molecular mechanisms by which miR-146a contributes to osteosarcoma (OS) remain unclear...
  80. Jin S, Cui J. BST2 inhibits type I IFN (interferon) signaling by accelerating MAVS degradation through CALCOCO2-directed autophagy. Autophagy. 2017;:1-6 pubmed publisher
    ..Recently, we have revealed that IFN (interferon)-induced BST2 recruits the E3 ubiquitin ligase MARCH8 to catalyze the K27-linked ubiquitination of MAVS for CALCOCO2-directed autophagic degradation, hence inhibiting ..
  81. Ofek P, Calderon M, Mehrabadi F, Krivitsky A, Ferber S, Tiram G, et al. Restoring the oncosuppressor activity of microRNA-34a in glioblastoma using a polyglycerol-based polyplex. Nanomedicine. 2016;12:2201-2214 pubmed publisher
    ..In this work, we aim to restore the oncosuppressor activity of microRNA-34a (miR-34a) in GBM...
  82. Schelch K, Kirschner M, Williams M, Cheng Y, van Zandwijk N, Grusch M, et al. A link between the fibroblast growth factor axis and the miR-16 family reveals potential new treatment combinations in mesothelioma. Mol Oncol. 2017;: pubmed publisher
    ..Several FGFs and FGF receptors (FGFRs) are predicted targets of the miR-15/16 family, which is downregulated in MPM...
  83. Layne C, Mulavara A, McDonald P, Pruett C, Kozlovskaya I, Bloomberg J. Effect of long-duration spaceflight on postural control during self-generated perturbations. J Appl Physiol (1985). 2001;90:997-1006 pubmed
    ..associated with arm movement of eight subjects who experienced long-duration spaceflight (3--6 mo) aboard the Mir space station...
  84. Zhang S, Hu F, Liang H, Liu Y, Yang J, Zhou W. Association between a miRNA-146a polymorphism and susceptibility to head and neck squamous cell carcinoma in Chinese patients: A meta-analysis of 8 case-control studies. PLoS ONE. 2017;12:e0186609 pubmed publisher
    ..A significant association was found between miR-146a rs2910164 polymorphisms and the risk of SCCHN in Chinese patients according to the overall data [CC+CG vs...
  85. Yi D, Su Q, Zhang F, Fu P, Zhang Q, Cen Y, et al. Effect of microRNA-128 on cisplatin resistance of glioma SHG-44 cells by targeting JAG1. J Cell Biochem. 2017;: pubmed publisher
    This current study intends to investigate the effect of microRNA-128 (miR-128) on cisplatin (DDP) resistance in glioma SHG-44 cells...
  86. Li Z, Ni J. Role of microRNA-26a in the diagnosis of lower extremity deep vein thrombosis in patients with bone trauma. Exp Ther Med. 2017;14:5069-5074 pubmed publisher
    The present study aimed to investigate the role and mechanism of action of microRNA (miR)-26a in deep vein thrombosis (DVT). Peripheral blood was collected from 45 patients with DVT and 40 healthy controls...
  87. Hu Y, Ma Z, He Y, Liu W, Su Y, Tang Z. PART-1 functions as a competitive endogenous RNA for promoting tumor progression by sponging miR-143 in colorectal cancer. Biochem Biophys Res Commun. 2017;490:317-323 pubmed publisher
    ..In addition, PART-1 functioned as a ceRNA of DNMT3A, by sponging miR-143. Finally,PART-1 induced tumor progression by regulating DNMT3A.
  88. Zhang T, Ma G, Zhang Y, Huo H, Zhao Y. miR-216b inhibits glioma cell migration and invasion through suppression of FoxM1. Oncol Rep. 2017;38:1751-1759 pubmed publisher
    ..In the present study, we aimed to detect the expression and biological role of miR-216b in glioma. Our data showed that miR-216b was significantly downregulated in human glioma tissues and cells...
  89. Dong Y, Liu Y, Jiang A, Li R, Yin M, Wang Y. MicroRNA-335 suppresses the proliferation, migration, and invasion of breast cancer cells by targeting EphA4. Mol Cell Biochem. 2018;439:95-104 pubmed publisher
    ..Previous research has shown that miR-335 is downregulated in breast cancer, and it has been shown to be a breast cancer suppressor...
  90. Tandon D, Dewangan J, Srivastava S, Garg V, Rath S. miRNA genetic variants: As potential diagnostic biomarkers for oral cancer. Pathol Res Pract. 2018;214:281-289 pubmed publisher
    ..The aim of this study is to investigate the association between miR-499 A/G and miR-149 C/T polymorphisms with susceptibility to development of Oral Squamous Cell Carcinoma (OSCC)...
  91. Deng L, Wang X, Jiang L, Yang J, Zhou X, Lu Z, et al. Modulation of miR-185-5p expression by EBV-miR-BART6 contributes to developmental differences in ABCG4 gene expression in human megakaryocytes. Int J Biochem Cell Biol. 2016;81:105-111 pubmed publisher
    ..reported that 14 viral microRNAs of megakaryocytes cultured with serum from patients with ITP, including ebv-miR-BART6, are up-regulated...
  92. Fang M, Du H, Han B, Xia G, Shi X, Zhang F, et al. Hypoxia-inducible microRNA-218 inhibits trophoblast invasion by targeting LASP1: Implications for preeclampsia development. Int J Biochem Cell Biol. 2017;87:95-103 pubmed publisher
    ..Here, we investigated the role of miR-218 in PE development...