LAT

Summary

Gene Symbol: LAT
Description: linker for activation of T cells
Alias: IMD52, LAT1, pp36, linker for activation of T-cells family member 1, 36 kDa phospho-tyrosine adapter protein, 36 kDa phospho-tyrosine adaptor protein, linker for activation of T cells, transmembrane adaptor, p36-38
Species: human
Products:     LAT

Top Publications

  1. Shan X, Wange R. Itk/Emt/Tsk activation in response to CD3 cross-linking in Jurkat T cells requires ZAP-70 and Lat and is independent of membrane recruitment. J Biol Chem. 1999;274:29323-30 pubmed
    ..Indeed, Itk was found to be constitutively targeted to the membrane fraction in both Jurkat and P116 cells. Lat, a prominent in vivo substrate of ZAP-70 that mediates assembly of multimolecular signaling complexes at the plasma ..
  2. Baker J, Majeti R, Tangye S, Weiss A. Protein tyrosine phosphatase CD148-mediated inhibition of T-cell receptor signal transduction is associated with reduced LAT and phospholipase Cgamma1 phosphorylation. Mol Cell Biol. 2001;21:2393-403 pubmed
    ..However, phospholipase Cgamma1 (PLCgamma1) and LAT were strikingly hypophosphorylated in CD148-expressing cells following TCR stimulation, whereas the phosphorylation ..
  3. Zhu M, Janssen E, Leung K, Zhang W. Molecular cloning of a novel gene encoding a membrane-associated adaptor protein (LAX) in lymphocyte signaling. J Biol Chem. 2002;277:46151-8 pubmed
    ..It shares no overall sequence homology with LAT and is not localized to lipid rafts...
  4. Zhang W, Sloan Lancaster J, Kitchen J, Trible R, Samelson L. LAT: the ZAP-70 tyrosine kinase substrate that links T cell receptor to cellular activation. Cell. 1998;92:83-92 pubmed
    ..Its function is demonstrated by inhibition of T cell activation following overexpression of a mutant form lacking critical tyrosine residues. Therefore, we propose to name the molecule LAT-linker for activation of T cells.
  5. Weber J, Orstavik S, Torgersen K, Danbolt N, Berg S, Ryan J, et al. Molecular cloning of the cDNA encoding pp36, a tyrosine-phosphorylated adaptor protein selectively expressed by T cells and natural killer cells. J Exp Med. 1998;187:1157-61 pubmed
    Activation of T and natural killer (NK) cells leads to the tyrosine phosphorylation of pp36 and to its association with several signaling molecules, including phospholipase Cgamma-1 and Grb2...
  6. Jevremovic D, Billadeau D, Schoon R, Dick C, Irvin B, Zhang W, et al. Cutting edge: a role for the adaptor protein LAT in human NK cell-mediated cytotoxicity. J Immunol. 1999;162:2453-6 pubmed
    ..Here, we describe a key role for the LAT (p36) adaptor protein in human NK cell activation...
  7. Zhang W, Trible R, Zhu M, Liu S, McGlade C, Samelson L. Association of Grb2, Gads, and phospholipase C-gamma 1 with phosphorylated LAT tyrosine residues. Effect of LAT tyrosine mutations on T cell angigen receptor-mediated signaling. J Biol Chem. 2000;275:23355-61 pubmed
    The linker for activation of T cells (LAT) is a critical adaptor molecule required for T cell antigen receptor (TCR)-mediated signaling and thymocyte development...
  8. Klem J, Verrett P, Kumar V, Schatzle J. 2B4 is constitutively associated with linker for the activation of T cells in glycolipid-enriched microdomains: properties required for 2B4 lytic function. J Immunol. 2002;169:55-62 pubmed
    ..as from primary murine cells, coimmunoprecipitates with the phosphoprotein linker for the activation of T cells (LAT), which is essential for TCR-mediated signaling...
  9. Trub T, Frantz J, Miyazaki M, Band H, Shoelson S. The role of a lymphoid-restricted, Grb2-like SH3-SH2-SH3 protein in T cell receptor signaling. J Biol Chem. 1997;272:894-902 pubmed
    ..Based on the known functions of bound effector molecules, Grap-mediated responses to antigen challenge may include endocytosis of the T cell receptor, cellular proliferation, and regulated entry into the cell cycle. ..

More Information

Publications102 found, 100 shown here

  1. Hartgroves L, Lin J, Langen H, Zech T, Weiss A, Harder T. Synergistic assembly of linker for activation of T cells signaling protein complexes in T cell plasma membrane domains. J Biol Chem. 2003;278:20389-94 pubmed
    Transmembrane adaptor molecule LAT (linker for activation of T cells) forms a central scaffold for signaling protein complexes that accumulate in the vicinity of activated T cell antigen receptors (TCR)...
  2. Roose J, Diehn M, Tomlinson M, Lin J, Alizadeh A, Botstein D, et al. T cell receptor-independent basal signaling via Erk and Abl kinases suppresses RAG gene expression. PLoS Biol. 2003;1:E53 pubmed
    ..a cluster of genes, including RAG-1 and RAG-2, is repressed by constitutive signals requiring the adapter molecules LAT and SLP-76. This TCR-like pathway results in constitutive low-level activity of Erk and Abl kinases...
  3. Koonpaew S, Janssen E, Zhu M, Zhang W. The importance of three membrane-distal tyrosines in the adaptor protein NTAL/LAB. J Biol Chem. 2004;279:11229-35 pubmed
    NTAL (non-T cell activation linker)/LAB (linker for activation of B cells) is a LAT (linker for activation of T cells)-like molecule that is expressed in B cells, mast cells, natural killer cells, and monocytes...
  4. Jiang Y, Cheng H. Evidence of LAT as a dual substrate for Lck and Syk in T lymphocytes. Leuk Res. 2007;31:541-5 pubmed
    b>LAT is a linker protein essential for activation of T lymphocytes. Its rapid tyrosine-phosphorylation upon T cell receptor (TCR) stimulation recruits downstream signaling molecules for membrane targeting and activation...
  5. Shen S, Zhu M, Lau J, Chuck M, Zhang W. The essential role of LAT in thymocyte development during transition from the double-positive to single-positive stage. J Immunol. 2009;182:5596-604 pubmed publisher
    The linker for activation of T cells (LAT) is an adaptor protein that couples TCR engagement to downstream signaling cascades...
  6. Finco T, Kadlecek T, Zhang W, Samelson L, Weiss A. LAT is required for TCR-mediated activation of PLCgamma1 and the Ras pathway. Immunity. 1998;9:617-26 pubmed
    ..Subsequent analysis of J.CaM2 demonstrated a severe deficiency in pp36/LAT expression, a recently cloned adaptor protein implicated in TCR signaling...
  7. Liu S, Fang N, Koretzky G, McGlade C. The hematopoietic-specific adaptor protein gads functions in T-cell signaling via interactions with the SLP-76 and LAT adaptors. Curr Biol. 1999;9:67-75 pubmed
    ..Gads also coimmunoprecipitated the tyrosine-phosphorylated form of the linker for activated T cells (LAT) adaptor protein following cross-linking of the T-cell receptor; this interaction was mediated by the Gads SH2 ..
  8. Zhang W, Sommers C, Burshtyn D, Stebbins C, DeJarnette J, Trible R, et al. Essential role of LAT in T cell development. Immunity. 1999;10:323-32 pubmed
    The linker molecule LAT is a substrate of the tyrosine kinases activated following TCR engagement. Phosphorylated LAT binds many critical signaling molecules...
  9. Wange R. LAT, the linker for activation of T cells: a bridge between T cell-specific and general signaling pathways. Sci STKE. 2000;2000:re1 pubmed
    ..for linking the proximal and distal portions of the TCR signaling pathway is the recently described protein, LAT. LAT is a 36-kD transmembrane protein that becomes rapidly tyrosine-phosphorylated after TCR engagement...
  10. Kabouridis P. Selective interaction of LAT (linker of activated T cells) with the open-active form of Lck in lipid rafts reveals a new mechanism for the regulation of Lck in T cells. Biochem J. 2003;371:907-15 pubmed
    ..In contrast to Lck, Fyn/V5-His was precipitated equally well from both fractions. In the LAT(linker of activated T cells)-deficient J...
  11. Cho S, Velikovsky C, Swaminathan C, Houtman J, Samelson L, Mariuzza R. Structural basis for differential recognition of tyrosine-phosphorylated sites in the linker for activation of T cells (LAT) by the adaptor Gads. EMBO J. 2004;23:1441-51 pubmed
    The transmembrane protein, linker for activation of T cells (LAT), is essential for T-cell activation and development...
  12. Houtman J, Yamaguchi H, Barda Saad M, Braiman A, Bowden B, Appella E, et al. Oligomerization of signaling complexes by the multipoint binding of GRB2 to both LAT and SOS1. Nat Struct Mol Biol. 2006;13:798-805 pubmed
    ..In T cells, the SH2 domain of GRB2 binds phosphorylated tyrosines on the adaptor protein LAT and the GRB2 SH3 domains associate with the proline-rich regions of SOS1 and CBL...
  13. Vasiliver Shamis G, Cho M, Hioe C, Dustin M. Human immunodeficiency virus type 1 envelope gp120-induced partial T-cell receptor signaling creates an F-actin-depleted zone in the virological synapse. J Virol. 2009;83:11341-55 pubmed publisher
    ..We propose a model in which the F-actin-depleted zone formed within the target CD4 T cell enhances the reception of virions by releasing the physical barrier for HIV-1 entry and facilitating postentry events. ..
  14. Balagopalan L, Ashwell B, Bernot K, Akpan I, Quasba N, Barr V, et al. Enhanced T-cell signaling in cells bearing linker for activation of T-cell (LAT) molecules resistant to ubiquitylation. Proc Natl Acad Sci U S A. 2011;108:2885-90 pubmed publisher
    Linker for activation of T cells (LAT) plays a central role in T-cell activation by nucleating signaling complexes that are critical for the propagation of T-cell signals from the plasma membrane to the cellular interior...
  15. Zhang W, Trible R, Samelson L. LAT palmitoylation: its essential role in membrane microdomain targeting and tyrosine phosphorylation during T cell activation. Immunity. 1998;9:239-46 pubmed
    The linker molecule LAT is a critical substrate of the tyrosine kinases activated upon TCR engagement. Phosphorylated LAT binds Grb2, PLC-gamma1, and other signaling molecules...
  16. Deckert M, Tartare Deckert S, Hernandez J, Rottapel R, Altman A. Adaptor function for the Syk kinases-interacting protein 3BP2 in IL-2 gene activation. Immunity. 1998;9:595-605 pubmed
    ..In addition to Zap-70, the 3BP2 SH2 domain associated in vitro with LAT, Grb2, PLCgamma1, and Cbl from activated T cell lysates...
  17. Balagopalan L, Barr V, Sommers C, Barda Saad M, Goyal A, Isakowitz M, et al. c-Cbl-mediated regulation of LAT-nucleated signaling complexes. Mol Cell Biol. 2007;27:8622-36 pubmed
    ..Upon receptor activation, the adapters LAT and SLP-76, visualized as chimeric proteins tagged with yellow fluorescent protein, transiently associate with and ..
  18. Yi D, Li B, Hou Y, Wang L, Zhao D, Chen H, et al. Dietary supplementation with an amino acid blend enhances intestinal function in piglets. Amino Acids. 2018;: pubmed publisher
    ..levels for porcine ?-defensin-1, sodium-independent amino acid transporters (b0,+AT and y+LAT1), aquaporin (AQP) 3, AQP8, AQP10, nuclear factor erythroid 2-related factor 2 and glutathione S-transferase omega-2,..
  19. Li L, Li Z, Wang E, Yang R, Xiao Y, Han H, et al. Herpes Simplex Virus 1 Infection of Tree Shrews Differs from That of Mice in the Severity of Acute Infection and Viral Transcription in the Peripheral Nervous System. J Virol. 2016;90:790-804 pubmed publisher
    ..from mice in the expression of key HSV-1 genes, including ICP0, ICP4, and latency-associated transcript (LAT)...
  20. Wu L, Liao P, He L, Ren W, Yin J, Duan J, et al. Growth performance, serum biochemical profile, jejunal morphology, and the expression of nutrients transporter genes in deoxynivalenol (DON)- challenged growing pigs. BMC Vet Res. 2015;11:144 pubmed publisher
    ..transporter-1 (PepT-1), cationic amino acid transporter-1 (CAT-1) and y(+)L-type amino acid transporter-1 (LAT-1) in control were slightly or markedly higher than those in the 3 DON treatment groups...
  21. Mauhin W, Habarou F, Gobin S, Servais A, Brassier A, Grisel C, et al. Update on Lysinuric Protein Intolerance, a Multi-faceted Disease Retrospective cohort analysis from birth to adulthood. Orphanet J Rare Dis. 2017;12:3 pubmed publisher
    ..recessive-inherited mutations in the SLC7A7 gene encoding the cationic amino-acids transporter subunit y+LAT1. The disease is characterised by protein-rich food intolerance with secondary urea cycle disorder, but symptoms are ..
  22. Saito Y, Moriya S, Kazama H, Hirasawa K, Miyahara K, Kokuba H, et al. Amino acid starvation culture condition sensitizes EGFR-expressing cancer cell lines to gefitinib-mediated cytotoxicity by inducing atypical necroptosis. Int J Oncol. 2018;52:1165-1177 pubmed publisher
    ..The knockdown of L-type amino acid transporter 1 (LAT-1) by siRNA also enhanced GEF-induced cytotoxicity...
  23. Nicolas C, Bednarek N, Vuiblet V, Boyer O, Brassier A, de Lonlay P, et al. Renal Involvement in a French Paediatric Cohort of Patients with Lysinuric Protein Intolerance. JIMD Rep. 2016;29:11-17 pubmed
    ..The SLC7A7 gene, mutated in LPI patients, encodes the light subunit (y+LAT1) of a member of the heterodimeric amino acid transporter family...
  24. Zhang B, Wu J, Jiao Y, Bock C, Dai M, Chen B, et al. Differential Requirements of TCR Signaling in Homeostatic Maintenance and Function of Dendritic Epidermal T Cells. J Immunol. 2015;195:4282-91 pubmed publisher
    ..In this study, we investigated TCR signaling in fully matured DETCs by lineage-restricted deletion of the Lat gene, an essential signaling molecule downstream of the TCR...
  25. Gullà A, Di Martino M, Gallo Cantafio M, Morelli E, Amodio N, Botta C, et al. A 13 mer LNA-i-miR-221 Inhibitor Restores Drug Sensitivity in Melphalan-Refractory Multiple Myeloma Cells. Clin Cancer Res. 2016;22:1222-33 pubmed publisher
    ..BBC3/PUMA protein, a miR-221/222 target, as well as with modulation of drug influx-efflux transporters SLC7A5/LAT1 and the ABC transporter ABCC1/MRP1...
  26. Straka E, Ellinger I, Balthasar C, Scheinast M, Schatz J, Szattler T, et al. Mercury toxicokinetics of the healthy human term placenta involve amino acid transporters and ABC transporters. Toxicology. 2016;340:34-42 pubmed publisher
    ..We found the amino acid transporter subunits L-type amino acid transporter (LAT)1 and rBAT (related to b(0,+) type amino acid transporter) as well as the efflux transporter multidrug resistance ..
  27. Keller B, Zaidman I, Yousefi O, Hershkovitz D, Stein J, Unger S, et al. Early onset combined immunodeficiency and autoimmunity in patients with loss-of-function mutation in LAT. J Exp Med. 2016;213:1185-99 pubmed publisher
    The adapter protein linker for activation of T cells (LAT) is a critical signaling hub connecting T cell antigen receptor triggering to downstream T cell responses...
  28. Ren J, Brann L, Bruening K, Scerpella T, Dowthwaite J. Relationships among diet, physical activity, and dual plane dual-energy X-ray absorptiometry bone outcomes in pre-pubertalgirls. Arch Osteoporos. 2017;12:19 pubmed publisher
    ..This cross-sectional analysis used paired PA and supine lateral (LAT) lumbar spine DXA scans to assess "3D" vertebral body bone mineral apparent density (PALATBMAD), "3D" index of ..
  29. Tanimura N, Nagafuku M, Minaki Y, Umeda Y, Hayashi F, Sakakura J, et al. Dynamic changes in the mobility of LAT in aggregated lipid rafts upon T cell activation. J Cell Biol. 2003;160:125-35 pubmed
    ..T cell activation, we analyzed the dynamic changes of a raft-associated protein, linker for activation of T cells (LAT), on T cell receptor stimulation using LAT fused to GFP (LAT-GFP)...
  30. An S, Lu X, Zhao W, Sun T, Zhang Y, Lu Y, et al. Amino Acid Metabolism Abnormity and Microenvironment Variation Mediated Targeting and Controlled Glioma Chemotherapy. Small. 2016;12:5633-5645 pubmed publisher
    ..As a result, large amino acid transporter 1 (LAT1) is remarkably overexpressed in both blood-brain-barrier and glioma tumor cells, leading a rapid and sufficient ..
  31. Kim C, Hoang C, Kesarwala A, Schrump D, Guha U, Rajan A. Role of Local Ablative Therapy in Patients with Oligometastatic and Oligoprogressive Non-Small Cell Lung Cancer. J Thorac Oncol. 2017;12:179-193 pubmed publisher
    ..Traditionally, local ablative therapy (LAT) has been limited to symptom palliation in patients with advanced NSCLC, but the presence of oligometastatic or ..
  32. Thomas J, Singh M, Goswami T, Glora P, Chakravarti S, Chander V, et al. Determination of immune status in dogs against CPV-2 by recombinant protein based latex agglutination test. Biologicals. 2017;49:51-56 pubmed publisher
    ..immune status prior to CPV-2 vaccination or to detect seroconversion in immunized dogs by latex agglutination test (LAT) using recombinant antigen...
  33. Pop T, Bejer A, Baran J, Szymczyk D. [Factors affecting the maintenance of occupational activity over a 2-3-year period after total hip replacement]. Med Pr. 2018;69:191-198 pubmed publisher
    ..Celem pracy by?a ocena statusu zawodowego osób po ca?kowitej endoprotezoplastyce stawu biodrowego w okresie 2–3 lat od zabiegu oraz analiza wp?ywu takich czynników, jak wiek, p?e?, BMI (body mass index – wska?nik masy cia?a), ..
  34. Ayuso P, Plaza Serón M, Doña I, Blanca López N, Campo P, Cornejo García J, et al. Association study of genetic variants in PLA2G4A, PLCG1, LAT, SYK, and TNFRS11A genes in NSAIDs-induced urticaria and/or angioedema patients. Pharmacogenet Genomics. 2015;25:618-21 pubmed publisher
    ..the association of nine single nucleotide polymorphisms in five genes involved in mast cell activation (SYK, LAT1, PLCG1, PLA2G4A, and TNFRSF11A) in 450 NIUA patients and 500 controls...
  35. Srivastava R, Dervillez X, Khan A, Chentoufi A, Chilukuri S, Shukr N, et al. The Herpes Simplex Virus Latency-Associated Transcript Gene Is Associated with a Broader Repertoire of Virus-Specific Exhausted CD8+ T Cells Retained within the Trigeminal Ganglia of Latently Infected HLA Transgenic Rabbits. J Virol. 2016;90:3913-3928 pubmed publisher
    ..A dynamic cross talk appears to occur between the HSV-1 latency-associated transcript (LAT), the only viral gene that is abundantly transcribed during latency, and the CD8(+)T cells that reside in HSV-1 ..
  36. Jiang X, Zhang Y, Yang Y, Yang J, Asico L, Chen W, et al. Gastrin stimulates renal dopamine production by increasing the renal tubular uptake of l-DOPA. Am J Physiol Endocrinol Metab. 2017;312:E1-E10 pubmed publisher
    ..renal dopamine production by increasing the cellular uptake of l-DOPA via the l-type amino acid transporter (LAT) at the plasma membrane...
  37. Diaz P, Dimasuay K, Koele Schmidt L, Jang B, Barbour L, Jansson T, et al. Glyburide treatment in gestational diabetes is associated with increased placental glucose transporter 1 expression and higher birth weight. Placenta. 2017;57:52-59 pubmed publisher
    ..1; GLUT1), amino acid (sodium-coupled neutral amino acid transporter 2; SNAT2 and L-type amino acid transporter 1; LAT1) and fatty acid (fatty acid translocase; FAT/CD36, fatty acid transporter 2 and 4; FATP2, FATP4) transporters was ..
  38. Bosselut R, Zhang W, Ashe J, Kopacz J, Samelson L, Singer A. Association of the adaptor molecule LAT with CD4 and CD8 coreceptors identifies a new coreceptor function in T cell receptor signal transduction. J Exp Med. 1999;190:1517-26 pubmed
    Linker for activation of T cells (LAT) is an adaptor protein whose tyrosine phosphorylation is critical for transduction of the T cell receptor (TCR) signal...
  39. Busin M, Breda C, Bertolin M, Bovone C, Ponzin D, Ferrari S, et al. Corneal Epithelial Stem Cells Repopulate the Donor Area within 1 Year from Limbus Removal for Limbal Autograft. Ophthalmology. 2016;123:2481-2488 pubmed publisher
    ..whether limbal epithelial stem cells (LESCs) repopulate the site harvested for limbal autograft transplantation (LAT), the expression of LESCs markers was evaluated in bioptic specimens obtained from the donor area 12 months or more ..
  40. Reshma R, Jeankumar V, Kapoor N, Saxena S, Bobesh K, Vachaspathy A, et al. Mycobacterium tuberculosis lysine-?-aminotransferase a potential target in dormancy: Benzothiazole based inhibitors. Bioorg Med Chem. 2017;25:2761-2771 pubmed publisher
    MTB lysine-?-aminotransferase (LAT) was found to play a crucial role in persistence and antibiotic tolerance. LAT serves as a potential target in the management of latent tuberculosis...
  41. Pikala M, Maniecka Bryła I. [Socioeconomic inequalities in mortality due to all causes in the working age population of Poland in 2002 and 2011]. Med Pr. 2017;68:771-778 pubmed publisher
    ..Analizą objęto zgony mieszkańców Polski w wieku 25–64 lat w 2002 r. (N = 97 004) i 2011 r. (N = 104 598)...
  42. Xie J, Liang J, Diao L, Altman A, Li Y. TNFR-associated factor 6 regulates TCR signaling via interaction with and modification of LAT adapter. J Immunol. 2013;190:4027-36 pubmed publisher
    ..This recruitment depends on TRAF6 interacting with linker for activation of T cells (LAT) via its TRAF domain...
  43. de la Ballina L, Cano Crespo S, González Muñoz E, Bial S, Estrach S, Cailleteau L, et al. Amino Acid Transport Associated to Cluster of Differentiation 98 Heavy Chain (CD98hc) Is at the Cross-road of Oxidative Stress and Amino Acid Availability. J Biol Chem. 2016;291:9700-11 pubmed publisher
    ..CD98hc-associated transporters (i.e. xCT, LAT1, and y(+)LAT2 in wild-type cells) are crucial to control reactive oxygen species and intracellular AA levels, thus ..
  44. Cormerais Y, Giuliano S, Lefloch R, Front B, Durivault J, Tambutte E, et al. Genetic Disruption of the Multifunctional CD98/LAT1 Complex Demonstrates the Key Role of Essential Amino Acid Transport in the Control of mTORC1 and Tumor Growth. Cancer Res. 2016;76:4481-92 pubmed publisher
    The CD98/LAT1 complex is overexpressed in aggressive human cancers and is thereby described as a potential therapeutic target...
  45. Ellinger I, Chatuphonprasert W, Reiter M, Voss A, Kemper J, Straka E, et al. Don't trust an(t)ybody - Pitfalls during investigation of candidate proteins for methylmercury transport at the placental interface. Placenta. 2016;43:13-6 pubmed publisher
    ..An anti-4F2hc- and one anti-LAT1-antibody were specific. Another anti-LAT1-antibody reacted with LAT2...
  46. Nguyen Van T, Ozaki A, Nguyen Tho H, Nguyen Duc A, Tran Thi Y, Kurosawa K. Arsenic and Heavy Metal Contamination in Soils under Different Land Use in an Estuary in Northern Vietnam. Int J Environ Res Public Health. 2016;13: pubmed
    ..The Ba Lat estuary of the Red River is the largest estuary in northern Vietnam and is employed in various land uses...
  47. Ahsan N, Belmont J, Chen Z, Clifton J, Salomon A. Highly reproducible improved label-free quantitative analysis of cellular phosphoproteome by optimization of LC-MS/MS gradient and analytical column construction. J Proteomics. 2017;165:69-74 pubmed publisher
    ..proteins previously established as important in T cell signaling including A-Raf, B-Raf, c-Myc, CARMA1, Fyn, ITK, LAT, NFAT1/2/3, PKC?, PLC?1/2, RAF1, and SOS1...
  48. Wagner C, Lang F, Broer S. Function and structure of heterodimeric amino acid transporters. Am J Physiol Cell Physiol. 2001;281:C1077-93 pubmed
    ..system b(0,+), whereas the homologous heavy chain 4F2hc interacts with several light chains to form system L (with LAT1 and LAT2), system y(+)L (with y(+)LAT1 and y(+)LAT2), system x (with xAT), or system asc (with asc1)...
  49. Li L, Li Z, Li X, Wang E, Lang F, Xia Y, et al. Reactivation of HSV-1 following explant of tree shrew brain. J Neurovirol. 2016;22:293-306 pubmed publisher
    ..report that HSV-1 enters the tree shrew brain following ocular inoculation and HSV-1 transcripts, ICP0, ICP4, and LAT can be detected at 5 days post-infection (p.i.), peaking at 10 days p.i...
  50. Ko M, Kim E, Gonzalez J, Tan J. Dose- and time-dependent effects of actomyosin inhibition on live mouse outflow resistance and aqueous drainage tissues. Sci Rep. 2016;6:21492 pubmed publisher
    ..We established methodology to reliably analyze the effect of latrunculin-B (Lat-B)-induced actin depolymerization on outflow physiology in live mice...
  51. Bao E, Chystsiakova A, Brahmajothi M, Sunday M, Pavlisko E, Wempe M, et al. Bronchopulmonary dysplasia impairs L-type amino acid transporter-1 expression in human and baboon lung. Pediatr Pulmonol. 2016;51:1048-1056 pubmed publisher
    ..in alveolar epithelial cells (AEC) are mediated by S-nitrosothiol uptake via L-type amino acid transporter-1 (LAT1)...
  52. Li L, Di X, Wu M, Sun Z, Zhong L, Wang Y, et al. Targeting tumor highly-expressed LAT1 transporter with amino acid-modified nanoparticles: Toward a novel active targeting strategy in breast cancer therapy. Nanomedicine. 2017;13:987-998 pubmed publisher
    ..Herein, we report a novel active targeting strategy based on the large amino acid transporter 1 (LAT1) overexpressed in a variety of cancers...
  53. Chen X, Li X, Gu W, Wang D, Chen Y, Guo X. LAT alleviates Th2/Treg imbalance in an OVA-induced allergic asthma mouse model through LAT-PLC-?1 interaction. Int Immunopharmacol. 2017;44:9-15 pubmed publisher
    Low expression of linker for activation of T cells (LAT) is observed in asthma...
  54. Tan J, Israf D, Md Hashim N, Cheah Y, Harith H, Shaari K, et al. LAT is essential for the mast cell stabilising effect of tHGA in IgE-mediated mast cell activation. Biochem Pharmacol. 2017;144:132-148 pubmed publisher
    ..analysed by using Western Blot to determine the effect of tHGA on various important signalling molecules in the LAT-PLC?-MAPK and PI3K-NF?B pathways...
  55. Habermeier A, Graf J, Sandhöfer B, Boissel J, Roesch F, Closs E. System L amino acid transporter LAT1 accumulates O-(2-fluoroethyl)-L-tyrosine (FET). Amino Acids. 2015;47:335-44 pubmed publisher
    ..In this work we demonstrate that [(3)H]L-tyrosine is primarily transported by the system L transporter LAT1 in human LN229 glioblastoma cells...
  56. Yothaisong S, Namwat N, Yongvanit P, Khuntikeo N, Puapairoj A, Jutabha P, et al. Increase in L-type amino acid transporter 1 expression during cholangiocarcinogenesis caused by liver fluke infection and its prognostic significance. Parasitol Int. 2017;66:471-478 pubmed publisher
    L-type amino acid transporter 1 (LAT1) is highly expressed in various human cancers, including cholangiocarcinoma (CCA), the most common cancer in Northeast Thailand...
  57. Griffié J, Shlomovich L, Williamson D, Shannon M, Aaron J, Khuon S, et al. 3D Bayesian cluster analysis of super-resolution data reveals LAT recruitment to the T cell synapse. Sci Rep. 2017;7:4077 pubmed publisher
    ..This tool is then deployed on novel experimental data as a proof of concept, illustrating the recruitment of LAT to the T-cell immunological synapse in data acquired by iPALM providing ~10?nm isotropic resolution.
  58. Zheng H, Hu P, Quinn D, Wang Y. Phosphotyrosine proteomic study of interferon alpha signaling pathway using a combination of immunoprecipitation and immobilized metal affinity chromatography. Mol Cell Proteomics. 2005;4:721-30 pubmed
    ..A specific site on alpha-tubulin (Tyr-271) was observed to be phosphorylated upon treatment as well. Furthermore, our results suggest that LOC257106, a CDC42 GAP-like protein, is potentially involved in this pathway. ..
  59. Nag A, Monine M, Perelson A, Goldstein B. Modeling and simulation of aggregation of membrane protein LAT with molecular variability in the number of binding sites for cytosolic Grb2-SOS1-Grb2. PLoS ONE. 2012;7:e28758 pubmed publisher
    The linker for activation of T cells (LAT), the linker for activation of B cells (LAB), and the linker for activation of X cells (LAX) form a family of transmembrane adaptor proteins widely expressed in lymphocytes...
  60. Kunii N, Zhao Y, Jiang S, Liu X, Scholler J, Balagopalan L, et al. Enhanced function of redirected human T cells expressing linker for activation of T cells that is resistant to ubiquitylation. Hum Gene Ther. 2013;24:27-37 pubmed publisher
    ..Linker for activation of T cells (LAT) plays a central role in T cell activation...
  61. Liang Z, Liu R, Zhang H, Zhang S, Hu X, Tan J, et al. GADD45 proteins inhibit HIV-1 replication through specific suppression of HIV-1 transcription. Virology. 2016;493:1-11 pubmed publisher
    ..Knockdown of endogenous GADD45 modestly activates HIV-1 in the J-Lat A72 latency cell line, which suggests GADD45 proteins might play a role in maintaining HIV-1 latency.
  62. Schrade M, Berland K, Eliassen S, Guzik M, Echevarria Bonet C, Sørby M, et al. The role of grain boundary scattering in reducing the thermal conductivity of polycrystalline XNiSn (X?=?Hf, Zr, Ti) half-Heusler alloys. Sci Rep. 2017;7:13760 pubmed publisher
    ..can be obtained through a concerted theory-experiment comparison of how the lattice thermal conductivity ? Lat(T) depends on temperature and crystallite size. Comparing theory and experiment for a range of Hf0...
  63. Liu S, Berry D, McGlade C. The role of Gads in hematopoietic cell signalling. Oncogene. 2001;20:6284-90 pubmed
    ..a critical role in signalling from the T cell receptor by promoting the formation of a complex between SLP-76 and LAT. This complex couples the T cell receptor to Ras through a novel pathway involving PLC-gamma1, Tec family kinases, ..
  64. Tanimura N, Saitoh S, Kawano S, Kosugi A, Miyake K. Palmitoylation of LAT contributes to its subcellular localization and stability. Biochem Biophys Res Commun. 2006;341:1177-83 pubmed
    ..Without palmitoylation, linker for activation of T cells (LAT), an adaptor molecule mediating T cell receptor signaling, is unable to localize in lipid rafts and to mediate T ..
  65. Horejsi V, Otahal P, Brdicka T. LAT--an important raft-associated transmembrane adaptor protein. Delivered on 6 July 2009 at the 34th FEBS Congress in Prague, Czech Republic. FEBS J. 2010;277:4383-97 pubmed publisher
    ..The most important leukocyte transmembrane adaptor protein is LAT (linker for activation of T cells), which is critically involved in T cell receptor signalling, but also plays ..
  66. Marshall A, van Geldermalsen M, Otte N, Anderson L, Lum T, Vellozzi M, et al. LAT1 is a putative therapeutic target in endometrioid endometrial carcinoma. Int J Cancer. 2016;139:2529-39 pubmed publisher
    l-type amino acid transporters (LAT1-4) are expressed in various cancer types and are involved in the uptake of essential amino acids such as leucine...
  67. Richardson S, Van Herck S, Delbaere J, McAllan B, Darras V. The affinity of transthyretin for T3 or T4 does not determine which form of the hormone accumulates in the choroid plexus. Gen Comp Endocrinol. 2018;264:131-137 pubmed publisher
    ..g. MCT8, MCT10, LAT1, OATP1C1) and deiodinases (D1, D2 and D3) which either activate or inactivate THs...
  68. Usuki F, Fujimura M, Yamashita A. Endoplasmic reticulum stress preconditioning modifies intracellular mercury content by upregulating membrane transporters. Sci Rep. 2017;7:12390 pubmed publisher
    ..preconditioning upregulated the expression of methionine transporters that affect the cellular influx of MeHg, LAT1, LAT3, and SNAT2; and a membrane transporter that affects the efflux of MeHg, ABCC4, in MeHg-susceptible myogenic ..
  69. Sarkar S. Tyrosine phosphorylation and translocation of LAT in platelets. FEBS Lett. 1998;441:357-60 pubmed
    ..However, some of these proteins are not identified. Recent studies showed that LAT is a syk substrate and is tyrosine phosphorylated during T cell stimulation...
  70. Tang J, Sawasdikosol S, Chang J, Burakoff S. SLAP, a dimeric adapter protein, plays a functional role in T cell receptor signaling. Proc Natl Acad Sci U S A. 1999;96:9775-80 pubmed
    ..Some adapter proteins, such as SLP-76, Vav, and LAT, positively regulate TCR-mediated signal transduction, whereas others, such as Cbl, play an inhibitory role...
  71. Huang W, Yan Q, Lin W, Chung J, Hansen S, Christensen S, et al. Phosphotyrosine-mediated LAT assembly on membranes drives kinetic bifurcation in recruitment dynamics of the Ras activator SOS. Proc Natl Acad Sci U S A. 2016;113:8218-23 pubmed publisher
    ..Here, we reconstitute phosphotyrosine-mediated assembly of extended linker for the activation of T cells (LAT):growth factor receptor-bound protein 2 (Grb2):Son of Sevenless (SOS) networks, derived from the T-cell receptor ..
  72. Bacchelli C, Moretti F, Carmo M, Adams S, Stanescu H, Pearce K, et al. Mutations in linker for activation of T cells (LAT) lead to a novel form of severe combined immunodeficiency. J Allergy Clin Immunol. 2017;139:634-642.e5 pubmed publisher
    ..Linker for activation of T cells (LAT) is a transmembrane adaptor signaling molecule that is part of the TCR complex and essential for T-cell development,..
  73. Hermida A, Kubala M, Traullé S, Buiciuc O, Quenum S, Hermida J. Prevalence and predictive factors of left atrial tachycardia occurring after second-generation cryoballoon ablation of atrial fibrillation. J Cardiovasc Electrophysiol. 2017;: pubmed publisher
    Assess the prevalence and predictors of left atrial tachycardia (LAT) after cryoballoon ablation of pulmonary veins.
  74. Entwisle T, Evans J, Vis M, Saunders G. Ottia meiospora (Ottiaceae, Rhodophyta), a new genus and family endophytic within the thallus of Nothocladus (Batrachospermales, Rhodophyta). J Phycol. 2017;: pubmed publisher
    ..Morphological observations provided little clarity around the reproductive morphology or the life cycle of this endophyte of Nothocladus s. lat. found commonly in mainland Australia but, to date, less so in New Zealand.
  75. Bonello G, Blanchard N, Montoya M, Aguado E, Langlet C, He H, et al. Dynamic recruitment of the adaptor protein LAT: LAT exists in two distinct intracellular pools and controls its own recruitment. J Cell Sci. 2004;117:1009-16 pubmed
    The integral membrane adaptor protein linker for activation of T cells (LAT) couples the T-cell receptor (TCR) with downstream signalling and is essential for T-cell development and activation...
  76. Hayashi K, Jutabha P, Endou H, Sagara H, Anzai N. LAT1 is a critical transporter of essential amino acids for immune reactions in activated human T cells. J Immunol. 2013;191:4080-5 pubmed publisher
    ..In this study, we show that L-type amino acid transporter 1 (LAT1) is a major transporter for essential amino acids into activated human T cells...
  77. Mello Andrade F, da Costa W, Pires W, Pereira F, Cardoso C, Lino Junior R, et al. Antitumor effectiveness and mechanism of action of Ru(II)/amino acid/diphosphine complexes in the peritoneal carcinomatosis progression. Tumour Biol. 2017;39:1010428317695933 pubmed publisher
    ..The treatment with the LAT1 inhibitor decreased the sensitivity of the Ehrlich ascites carcinoma cells to complexes 1 and 2 in vitro-which ..
  78. García Blesa A, Klossowicz M, López Osuna C, Martínez Florensa M, Malissen B, García Cózar F, et al. The membrane adaptor LAT is proteolytically cleaved following Fas engagement in a tyrosine phosphorylation-dependent fashion. Biochem J. 2013;450:511-21 pubmed publisher
    Engagement of the TCR (T-cell receptor) induces tyrosine phosphorylation of the LAT (linker for the activation of T-cells) adaptor, and thereby it recruits several cytosolic mediators for downstream signalling pathways...
  79. Balagopalan L, Barr V, Kortum R, Park A, Samelson L. Cutting edge: cell surface linker for activation of T cells is recruited to microclusters and is active in signaling. J Immunol. 2013;190:3849-53 pubmed publisher
    ..has recently emerged regarding the location of the cellular pool of the adapter linker for activation of T cells (LAT) that participates in propagation of signals downstream of the TCR...
  80. Tisè M, Ferrante L, Mora S, Tagliabracci A. A biochemical approach for assessing cutoffs at the age thresholds of 14 and 18 years: a pilot study on the applicability of bone specific alkaline phosphatase on an Italian sample. Int J Legal Med. 2016;130:1149-58 pubmed publisher
    ..We focused on the legal age thresholds of 14 and 18 years (LAT) because, in Italy, the former is considered the minimum age for criminal responsibility and the latter defines ..
  81. Matalon O, Fried S, Ben Shmuel A, Pauker M, Joseph N, Keizer D, et al. Dephosphorylation of the adaptor LAT and phospholipase C-γ by SHP-1 inhibits natural killer cell cytotoxicity. Sci Signal. 2016;9:ra54 pubmed publisher
    ..We reveal that the adaptor protein linker for activation of T cells (LAT) as well as phospholipase C-γ1 (PLC-γ1) and PLC-γ2 are SHP-1 substrates...
  82. Stein M, Chen C, Jain S, Jensen K, He F, Heeringa S, et al. Genetic risk variants for social anxiety. Am J Med Genet B Neuropsychiatr Genet. 2017;174:120-131 pubmed publisher
    ..GWAS were conducted within ancestral groups (EUR, AFR, LAT) using linear regression models for each of the three component studies in Army STARRS, and then meta-analyzed ..
  83. Honjo H, Toh Y, Sohda M, Suzuki S, Kaira K, Kanai Y, et al. Clinical Significance and Phenotype of MTA1 Expression in Esophageal Squamous Cell Carcinoma. Anticancer Res. 2017;37:4147-4155 pubmed
    ..We investigated the clinical relationship between MTA1, LAT1, and tumor metabolism, as evaluated by positron emission tomography (PET) in esophageal squamous cell carcinoma...
  84. Kaminski N, Wong E. Differential mRNA expression of nutrient transporters in male and female chickens. Poult Sci. 2017;: pubmed publisher
    ..mRNA abundance of aminopeptidase N (APN), a peptide (PepT1), 6 amino acid transporters (ASCT1, bo,+AT, CAT1, EAAT3, LAT1, and y+LAT2), and 3 monosaccharide (GLUT2, GLUT5, and SGLT1) transporters was assayed by real-time PCR...
  85. Paz G, Iglesias Soler E, Willardson J, de Freitas Maia M, Miranda H. Postexercise Hypotension and Heart Rate Variability Responses Subsequent to Traditional, Paired Set, and Superset Training Methods. J Strength Cond Res. 2017;: pubmed publisher
    ..a randomized design, which included: Traditional Set (TS) - three successive sets for the lying bench press (LBP), lat pulldown (LPD), incline 45° bench press (BP45), seated close-grip row (SCR), triceps extension (TE), and biceps ..
  86. Yamamoto Y, Sawa R, Wake I, Morimoto A, Okimura Y. Glucose-mediated inactivation of AMP-activated protein kinase reduces the levels of L-type amino acid transporter 1 mRNA in C2C12 cells. Nutr Res. 2017;47:13-20 pubmed publisher
    ..We examined whether glucose reduces the expression of L-type amino acid transporter 1 (LAT1), which transports neutral amino acids, including BCAA, in C2C12 myocytes...
  87. Lupher M, Reedquist K, Miyake S, Langdon W, Band H. A novel phosphotyrosine-binding domain in the N-terminal transforming region of Cbl interacts directly and selectively with ZAP-70 in T cells. J Biol Chem. 1996;271:24063-8 pubmed
  88. Gringhuis S, Papendrecht van der Voort E, Leow A, Nivine Levarht E, Breedveld F, Verweij C. Effect of redox balance alterations on cellular localization of LAT and downstream T-cell receptor signaling pathways. Mol Cell Biol. 2002;22:400-11 pubmed
    The integral membrane protein linker for activation of T cells (LAT) is a central adapter protein in the T-cell receptor (TCR)-mediated signaling pathways...
  89. Sapsirisavat V, Phanuphak N, Keadpudsa S, Egan J, Pussadee K, Klaytong P, et al. Psychosocial and Behavioral Characteristics of High-Risk Men Who Have Sex with Men (MSM) of Unknown HIV Positive Serostatus in Bangkok, Thailand. AIDS Behav. 2016;20:386-397 pubmed
    ..or anal sex with a woman in the past 12 months, 39 % had condomless receptive sex with men and 21 % went to Lat Phrao to find a sexual partner...
  90. Ertz D, Heuchert B, Braun U, Freebury C, Common R, Diederich P. Contribution to the phylogeny and taxonomy of the genus Taeniolella, with a focus on lichenicolous taxa. Fungal Biol. 2016;120:1416-1447 pubmed publisher
    ..b>lat., Karschia, Labrocarpon, Melaspilea s. lat., and Stictographa...
  91. Soto Iglesias D, Duchateau N, Kostantyn Butakov C, Andreu D, Fernández Armenta J, Bijnens B, et al. Quantitative Analysis of Electro-Anatomical Maps: Application to an Experimental Model of Left Bundle Branch Block/Cardiac Resynchronization Therapy. IEEE J Transl Eng Health Med. 2017;5:1900215 pubmed publisher
    ..CRT) lead positioning, interpretation of global (total activation time), and local indices (local activation time (LAT), surrogates of conduction velocity, inter-ventricular, and transmural delays) that characterize changes in the ..
  92. Dong S, Corre B, Nika K, Pellegrini S, Michel F. T cell receptor signal initiation induced by low-grade stimulation requires the cooperation of LAT in human T cells. PLoS ONE. 2010;5:e15114 pubmed publisher
    ..TCR stimulation led to the co-precipitation of Lck with the transmembrane adaptor protein LAT (linker for activation of T cells), Erk-mediated phosphorylation of Lck and no detectable dephosphorylation of Lck ..