KL

Summary

Gene Symbol: KL
Description: klotho
Alias: klotho
Species: human
Products:     KL

Top Publications

  1. Hu M, Shi M, Zhang J, QUINONES H, Griffith C, Kuro O M, et al. Klotho deficiency causes vascular calcification in chronic kidney disease. J Am Soc Nephrol. 2011;22:124-36 pubmed publisher
    Soft-tissue calcification is a prominent feature in both chronic kidney disease (CKD) and experimental Klotho deficiency, but whether Klotho deficiency is responsible for the calcification in CKD is unknown...
  2. Pan J, Zhong J, Gan L, Chen S, Jin H, Wang X, et al. Klotho, an anti-senescence related gene, is frequently inactivated through promoter hypermethylation in colorectal cancer. Tumour Biol. 2011;32:729-35 pubmed publisher
    The potential anti-senescence gene Klotho (KL) has been recently found to participate in the progression of several different human cancers including breast, lung, and cervical cancer...
  3. Pedersen L, Pedersen S, Brasen C, Rasmussen L. Soluble serum Klotho levels in healthy subjects. Comparison of two different immunoassays. Clin Biochem. 2013;46:1079-1083 pubmed publisher
    Soluble serum Klotho is a new biomarker linked to chronic kidney disease, cardiovascular disease and diabetes...
  4. Tangri N, Alam A, Wooten E, Huggins G. Lack of association of Klotho gene variants with valvular and vascular calcification in Caucasians: a candidate gene study of the Framingham Offspring Cohort. Nephrol Dial Transplant. 2011;26:3998-4002 pubmed publisher
    ..b>Klotho is a gene primarily expressed in the kidney that has an important role in calcium-phosphate homeostasis...
  5. Cha S, Hu M, Kurosu H, Kuro O M, Moe O, Huang C. Regulation of renal outer medullary potassium channel and renal K(+) excretion by Klotho. Mol Pharmacol. 2009;76:38-46 pubmed publisher
    b>Klotho is an aging-suppression protein predominantly expressed in kidney, parathyroid glands, and choroids plexus of the brain...
  6. Liu J, Liu S, Morgenthaler N, Wong M, Tavintharan S, Sum C, et al. Association of plasma soluble ?-klotho with pro-endothelin-1 in patients with type 2 diabetes. Atherosclerosis. 2014;233:415-8 pubmed publisher
    To study the relationship between plasma soluble klotho (sKlotho) and pro-endothelin-1 (proET-1) in patients with type 2 diabetes (T2DM). In this cross-sectional study, we recruited 175 T2DM subjects and 56 non-diabetic controls...
  7. Ikushima M, Rakugi H, Ishikawa K, Maekawa Y, Yamamoto K, Ohta J, et al. Anti-apoptotic and anti-senescence effects of Klotho on vascular endothelial cells. Biochem Biophys Res Commun. 2006;339:827-32 pubmed
    b>Klotho-mutated mice manifest multiple age-related disorders that are observed in humans. A recent study suggested that Klotho protein might function as an anti-aging hormone in mammals...
  8. Kim Y, Kim J, Nam Y, Kong M, Kim Y, Yu K, et al. Klotho is a genetic risk factor for ischemic stroke caused by cardioembolism in Korean females. Neurosci Lett. 2006;407:189-94 pubmed
    An aging-suppressor gene, klotho, is a candidate factor for vascular disease because its deficiency leads to impaired endothelium-dependent vasodilation and impaired angiogenesis...
  9. de Oliveira R. Klotho RNAi induces premature senescence of human cells via a p53/p21 dependent pathway. FEBS Lett. 2006;580:5753-8 pubmed
    b>Klotho has recently emerged as a regulator of aging. To investigate the role of Klotho in the regulation of cellular senescence, we generated stable MRC-5 human primary fibroblast cells knockdown for Klotho expression by RNAi...
  10. Akimoto T, Yoshizawa H, Watanabe Y, Numata A, Yamazaki T, Takeshima E, et al. Characteristics of urinary and serum soluble Klotho protein in patients with different degrees of chronic kidney disease. BMC Nephrol. 2012;13:155 pubmed publisher
    b>Klotho is a single-pass transmembrane protein, which appears to be implicated in aging...

Detail Information

Publications73

  1. Hu M, Shi M, Zhang J, QUINONES H, Griffith C, Kuro O M, et al. Klotho deficiency causes vascular calcification in chronic kidney disease. J Am Soc Nephrol. 2011;22:124-36 pubmed publisher
    Soft-tissue calcification is a prominent feature in both chronic kidney disease (CKD) and experimental Klotho deficiency, but whether Klotho deficiency is responsible for the calcification in CKD is unknown...
  2. Pan J, Zhong J, Gan L, Chen S, Jin H, Wang X, et al. Klotho, an anti-senescence related gene, is frequently inactivated through promoter hypermethylation in colorectal cancer. Tumour Biol. 2011;32:729-35 pubmed publisher
    The potential anti-senescence gene Klotho (KL) has been recently found to participate in the progression of several different human cancers including breast, lung, and cervical cancer...
  3. Pedersen L, Pedersen S, Brasen C, Rasmussen L. Soluble serum Klotho levels in healthy subjects. Comparison of two different immunoassays. Clin Biochem. 2013;46:1079-1083 pubmed publisher
    Soluble serum Klotho is a new biomarker linked to chronic kidney disease, cardiovascular disease and diabetes...
  4. Tangri N, Alam A, Wooten E, Huggins G. Lack of association of Klotho gene variants with valvular and vascular calcification in Caucasians: a candidate gene study of the Framingham Offspring Cohort. Nephrol Dial Transplant. 2011;26:3998-4002 pubmed publisher
    ..b>Klotho is a gene primarily expressed in the kidney that has an important role in calcium-phosphate homeostasis...
  5. Cha S, Hu M, Kurosu H, Kuro O M, Moe O, Huang C. Regulation of renal outer medullary potassium channel and renal K(+) excretion by Klotho. Mol Pharmacol. 2009;76:38-46 pubmed publisher
    b>Klotho is an aging-suppression protein predominantly expressed in kidney, parathyroid glands, and choroids plexus of the brain...
  6. Liu J, Liu S, Morgenthaler N, Wong M, Tavintharan S, Sum C, et al. Association of plasma soluble ?-klotho with pro-endothelin-1 in patients with type 2 diabetes. Atherosclerosis. 2014;233:415-8 pubmed publisher
    To study the relationship between plasma soluble klotho (sKlotho) and pro-endothelin-1 (proET-1) in patients with type 2 diabetes (T2DM). In this cross-sectional study, we recruited 175 T2DM subjects and 56 non-diabetic controls...
  7. Ikushima M, Rakugi H, Ishikawa K, Maekawa Y, Yamamoto K, Ohta J, et al. Anti-apoptotic and anti-senescence effects of Klotho on vascular endothelial cells. Biochem Biophys Res Commun. 2006;339:827-32 pubmed
    b>Klotho-mutated mice manifest multiple age-related disorders that are observed in humans. A recent study suggested that Klotho protein might function as an anti-aging hormone in mammals...
  8. Kim Y, Kim J, Nam Y, Kong M, Kim Y, Yu K, et al. Klotho is a genetic risk factor for ischemic stroke caused by cardioembolism in Korean females. Neurosci Lett. 2006;407:189-94 pubmed
    An aging-suppressor gene, klotho, is a candidate factor for vascular disease because its deficiency leads to impaired endothelium-dependent vasodilation and impaired angiogenesis...
  9. de Oliveira R. Klotho RNAi induces premature senescence of human cells via a p53/p21 dependent pathway. FEBS Lett. 2006;580:5753-8 pubmed
    b>Klotho has recently emerged as a regulator of aging. To investigate the role of Klotho in the regulation of cellular senescence, we generated stable MRC-5 human primary fibroblast cells knockdown for Klotho expression by RNAi...
  10. Akimoto T, Yoshizawa H, Watanabe Y, Numata A, Yamazaki T, Takeshima E, et al. Characteristics of urinary and serum soluble Klotho protein in patients with different degrees of chronic kidney disease. BMC Nephrol. 2012;13:155 pubmed publisher
    b>Klotho is a single-pass transmembrane protein, which appears to be implicated in aging...
  11. Deary I, Harris S, Fox H, Hayward C, Wright A, Starr J, et al. KLOTHO genotype and cognitive ability in childhood and old age in the same individuals. Neurosci Lett. 2005;378:22-7 pubmed
    This study examined the influence of a variation in the KLOTHO gene on cognitive ability at age 11 and age 79 in 464 people from the Lothian Birth Cohort 1921 (LBC1921), and at age 11 and age 64 in 451 people in the Aberdeen Birth Cohort ..
  12. Kato Y, Arakawa E, Kinoshita S, Shirai A, Furuya A, Yamano K, et al. Establishment of the anti-Klotho monoclonal antibodies and detection of Klotho protein in kidneys. Biochem Biophys Res Commun. 2000;267:597-602 pubmed
    A novel gene, klotho (kl), which is involved in the development of a syndrome resembling human aging in mice, was recently identified...
  13. Kuro O M, Matsumura Y, Aizawa H, Kawaguchi H, Suga T, Utsugi T, et al. Mutation of the mouse klotho gene leads to a syndrome resembling ageing. Nature. 1997;390:45-51 pubmed
    A new gene, termed klotho, has been identified that is involved in the suppression of several ageing phenotypes...
  14. Semba R, Cappola A, Sun K, Bandinelli S, Dalal M, Crasto C, et al. Relationship of low plasma klotho with poor grip strength in older community-dwelling adults: the InCHIANTI study. Eur J Appl Physiol. 2012;112:1215-20 pubmed publisher
    ..The aging suppressor gene klotho encodes a single-pass transmembrane protein that is secreted as a circulating hormone...
  15. Imura A, Iwano A, Tohyama O, Tsuji Y, Nozaki K, Hashimoto N, et al. Secreted Klotho protein in sera and CSF: implication for post-translational cleavage in release of Klotho protein from cell membrane. FEBS Lett. 2004;565:143-7 pubmed
    b>Klotho mutant mice exhibit a set of phenotypes resembling human ageing. Although the function of Klotho remains unclear, mediation of its pleiotropic functions by putative humoral factor(s) has been presumed...
  16. Doi S, Zou Y, Togao O, Pastor J, John G, Wang L, et al. Klotho inhibits transforming growth factor-beta1 (TGF-beta1) signaling and suppresses renal fibrosis and cancer metastasis in mice. J Biol Chem. 2011;286:8655-65 pubmed publisher
    ..ureteral obstruction and metastasis of human cancer xenografts are suppressed by administration of secreted Klotho protein to mice. Klotho is a single-pass transmembrane protein expressed in renal tubular epithelial cells...
  17. Pavik I, Jaeger P, Ebner L, Poster D, Krauer F, Kistler A, et al. Soluble klotho and autosomal dominant polycystic kidney disease. Clin J Am Soc Nephrol. 2012;7:248-57 pubmed publisher
    ..This study explored potential mechanisms underlying resistance to FGF23 in ADPKD. FGF23 and klotho levels were measured, and renal phosphate transport was evaluated by calculating the ratio of the maximum rate of ..
  18. Kitagawa M, Sugiyama H, Morinaga H, Inoue T, Takiue K, Ogawa A, et al. A decreased level of serum soluble Klotho is an independent biomarker associated with arterial stiffness in patients with chronic kidney disease. PLoS ONE. 2013;8:e56695 pubmed publisher
    b>Klotho was originally identified in a mutant mouse strain unable to express the gene that consequently showed shortened life spans...
  19. German D, Khobahy I, Pastor J, Kuro O M, Liu X. Nuclear localization of Klotho in brain: an anti-aging protein. Neurobiol Aging. 2012;33:1483.e25-30 pubmed publisher
    b>Klotho is a putative age-suppressing gene whose overexpression in mice results in extension of life span...
  20. Arking D, Atzmon G, Arking A, Barzilai N, Dietz H. Association between a functional variant of the KLOTHO gene and high-density lipoprotein cholesterol, blood pressure, stroke, and longevity. Circ Res. 2005;96:412-8 pubmed
    We previously identified a functional variant of KLOTHO, termed KL-VS, that is associated with human aging and early-onset occult coronary artery disease...
  21. Neidert M, Sze L, Zwimpfer C, Sarnthein J, Seifert B, Frei K, et al. Soluble ?-klotho: a novel serum biomarker for the activity of GH-producing pituitary adenomas. Eur J Endocrinol. 2013;168:575-83 pubmed publisher
    b>Klotho is a lifespan-influencing gene expressed mainly in the kidneys. Soluble ?-Klotho (?KL) is released into the circulation...
  22. Zhu Y, Xu L, Zhang J, Xu W, Liu Y, Yin H, et al. Klotho suppresses tumor progression via inhibiting PI3K/Akt/GSK3?/Snail signaling in renal cell carcinoma. Cancer Sci. 2013;104:663-71 pubmed publisher
    b>Klotho is an anti-aging protein predominantly expressed in renal tubular epithelial cells...
  23. Kacso I, Bondor C, Kacso G. Soluble serum Klotho in diabetic nephropathy: relationship to VEGF-A. Clin Biochem. 2012;45:1415-20 pubmed publisher
    Both kidney expression and soluble serum Klotho are influenced by chronic kidney disease (CKD) and diabetes. Serum Klotho is a yet poorly explored biomarker...
  24. Kawano K, Ogata N, Chiano M, Molloy H, Kleyn P, Spector T, et al. Klotho gene polymorphisms associated with bone density of aged postmenopausal women. J Bone Miner Res. 2002;17:1744-51 pubmed
    Because mice deficient in klotho gene expression exhibit multiple aging phenotypes including osteopenia, we explored the possibility that the klotho gene may contribute to age-related bone loss in humans by examining the association ..
  25. Siahanidou T, Garatzioti M, Lazaropoulou C, Kourlaba G, Papassotiriou I, Kino T, et al. Plasma soluble ?-klotho protein levels in premature and term neonates: correlations with growth and metabolic parameters. Eur J Endocrinol. 2012;167:433-40 pubmed publisher
    b>Klotho (?-KL), a protein with antiaging properties, regulates phosphate, calcium, and bone metabolism, induces resistance to oxidative stress, and may participate in insulin signaling...
  26. Shimamura Y, Hamada K, Inoue K, Ogata K, Ishihara M, Kagawa T, et al. Serum levels of soluble secreted ?-Klotho are decreased in the early stages of chronic kidney disease, making it a probable novel biomarker for early diagnosis. Clin Exp Nephrol. 2012;16:722-9 pubmed publisher
    b>Klotho was first identified as an aging gene and was later shown to be a regulator of phosphate metabolism. Fibroblast growth factor 23 (FGF23) is the key regulator of phosphate metabolism...
  27. Telci D, Dogan A, Ozbek E, Polat E, Simsek A, Cakir S, et al. KLOTHO gene polymorphism of G395A is associated with kidney stones. Am J Nephrol. 2011;33:337-43 pubmed publisher
    b>KLOTHO, a type-1 transmembrane protein with glucurodinase activity, is expressed in tissues responsible for calcium homeostasis such as the kidney, parathyroid gland and the epithelium of the choroid plexus in the brain...
  28. Usuda J, Ichinose S, Ishizumi T, Ohtani K, Inoue T, Saji H, et al. Klotho is a novel biomarker for good survival in resected large cell neuroendocrine carcinoma of the lung. Lung Cancer. 2011;72:355-9 pubmed publisher
    ..In this study, we focused on the Klotho gene, which is an anti-aging gene known to be a potential tumor suppressor...
  29. Lim K, Lu T, Molostvov G, Lee C, Lam F, Zehnder D, et al. Vascular Klotho deficiency potentiates the development of human artery calcification and mediates resistance to fibroblast growth factor 23. Circulation. 2012;125:2243-55 pubmed publisher
    b>Klotho is known to function as a cofactor for the phosphatonin, fibroblast growth factor (FGF)-23 at the kidney. FGF-23 levels rise in chronic kidney disease (CKD) despite progression of accelerated vascular calcification...
  30. Navarro González J, Donate Correa J, Muros de Fuentes M, Pérez Hernández H, Martinez Sanz R, Mora Fernández C. Reduced Klotho is associated with the presence and severity of coronary artery disease. Heart. 2014;100:34-40 pubmed publisher
    b>Klotho is involved in vascular health. We aimed to analyse in a cross-sectional study the relationship between Klotho and human coronary artery disease (CAD)...
  31. Asai O, Nakatani K, Tanaka T, Sakan H, Imura A, Yoshimoto S, et al. Decreased renal ?-Klotho expression in early diabetic nephropathy in humans and mice and its possible role in urinary calcium excretion. Kidney Int. 2012;81:539-47 pubmed publisher
    Hypercalciuria is one of the early manifestations of diabetic nephropathy. We explored here the role of ?-Klotho, a protein expressed predominantly in distal convoluted tubules that has a role in calcium reabsorption...
  32. Lee J, Jeong D, Kim J, Lee S, Park J, Chang B, et al. The anti-aging gene KLOTHO is a novel target for epigenetic silencing in human cervical carcinoma. Mol Cancer. 2010;9:109 pubmed publisher
    b>Klotho was originally characterized as an anti-aging gene that predisposed Klotho-deficient mice to a premature aging-like syndrome. Recently, KLOTHO was reported to function as a secreted Wnt antagonist and as a tumor suppressor...
  33. Hu M, Kuro O M, Moe O. Secreted klotho and chronic kidney disease. Adv Exp Med Biol. 2012;728:126-57 pubmed publisher
    Soluble Klotho (sKl) in the circulation can be generated directly by alterative splicing of the Klotho transcript or the extracellular domain of membrane Klotho can be released from membrane-anchored Klotho on the cell surface...
  34. Arking D, Becker D, Yanek L, Fallin D, Judge D, Moy T, et al. KLOTHO allele status and the risk of early-onset occult coronary artery disease. Am J Hum Genet. 2003;72:1154-61 pubmed
    We previously identified a functional variant of KLOTHO (termed "KL-VS"), which harbors two amino acid substitutions in complete linkage disequilibrium and is associated with reduced human longevity when in homozygosity...
  35. Shimoyama Y, Nishio K, Hamajima N, Niwa T. KLOTHO gene polymorphisms G-395A and C1818T are associated with lipid and glucose metabolism, bone mineral density and systolic blood pressure in Japanese healthy subjects. Clin Chim Acta. 2009;406:134-8 pubmed publisher
    We investigated the association of KLOTHO gene single nucleotide polymorphisms (SNPs) with various laboratory data in 476 Japanese healthy subjects...
  36. Abramovitz L, Rubinek T, Ligumsky H, Bose S, Barshack I, Avivi C, et al. KL1 internal repeat mediates klotho tumor suppressor activities and inhibits bFGF and IGF-I signaling in pancreatic cancer. Clin Cancer Res. 2011;17:4254-66 pubmed publisher
    b>Klotho is a transmembrane protein which can be shed, act as a circulating hormone and modulate the insulin-like growth factor (IGF)-I and the fibroblast growth factor (FGF) pathways...
  37. Wolf I, Levanon Cohen S, Bose S, Ligumsky H, Sredni B, Kanety H, et al. Klotho: a tumor suppressor and a modulator of the IGF-1 and FGF pathways in human breast cancer. Oncogene. 2008;27:7094-105 pubmed publisher
    b>Klotho is an anti-aging gene, which has been shown to inhibit the insulin and insulin-like growth factor 1 (IGF-1) pathways in mice hepatocytes and myocytes...
  38. Crasto C, Semba R, Sun K, Cappola A, Bandinelli S, Ferrucci L. Relationship of low-circulating "anti-aging" klotho hormone with disability in activities of daily living among older community-dwelling adults. Rejuvenation Res. 2012;15:295-301 pubmed publisher
    The aging suppressor gene klotho encodes a single-pass transmembrane protein klotho that in mice is known to extend life span when overexpressed and to resemble accelerated aging, with skeletal muscle atrophy and decreased bone mineral ..
  39. Sakan H, Nakatani K, Asai O, Imura A, Tanaka T, Yoshimoto S, et al. Reduced renal ?-Klotho expression in CKD patients and its effect on renal phosphate handling and vitamin D metabolism. PLoS ONE. 2014;9:e86301 pubmed publisher
    Renal ?-Klotho (?-KL) plays a fundamental role as a co-receptor for fibroblast growth factor 23 (FGF23), a phosphaturic hormone and regulator of 1,25(OH)2 vitamin D3 (1,25VitD3)...
  40. Gkentzi D, Efthymiadou A, Kritikou D, Chrysis D. Fibroblast growth factor 23 and Klotho serum levels in healthy children. Bone. 2014;66:8-14 pubmed publisher
    Data for fibroblast growth factor 23 (FGF23) and particularly for Klotho in healthy children are limited...
  41. Torres P, Prie D, Molina Blétry V, Beck L, Silve C, Friedlander G. Klotho: an antiaging protein involved in mineral and vitamin D metabolism. Kidney Int. 2007;71:730-7 pubmed
    b>Klotho gene mutation leads to a syndrome strangely resembling chronic kidney disease patients undergoing dialysis with multiple accelerated age-related disorders, including hypoactivity, sterility, skin thinning, muscle atrophy, ..
  42. Low A, O Donnell C, Kathiresan S, Everett B, Chae C, Shaw S, et al. Aging syndrome genes and premature coronary artery disease. BMC Med Genet. 2005;6:38 pubmed
    ..A second gene related to premature aging in man and in murine models is the KLOTHO gene, a hypomorphic variant of which (KL-VS) is significantly more common in the first-degree relatives of ..
  43. Zhang C, Liang Y, Lei L, Zhu G, Chen X, Jin T, et al. Hypermethylations of RASAL1 and KLOTHO is associated with renal dysfunction in a Chinese population environmentally exposed to cadmium. Toxicol Appl Pharmacol. 2013;271:78-85 pubmed publisher
    ..It has been suggested that hypermethylation of the genes RASAL1 and KLOTHO is associated with renal fibrogenesis...
  44. Liu F, Wu S, Ren H, Gu J. Klotho suppresses RIG-I-mediated senescence-associated inflammation. Nat Cell Biol. 2011;13:254-62 pubmed publisher
    ..b>Klotho has been associated with ageing...
  45. Koh N, Fujimori T, Nishiguchi S, Tamori A, Shiomi S, Nakatani T, et al. Severely reduced production of klotho in human chronic renal failure kidney. Biochem Biophys Res Commun. 2001;280:1015-20 pubmed
    We recently identified a novel gene, termed klotho (kl) that is involved in the development of a syndrome in mice resembling human aging...
  46. Witkowski J, Soroczyńska Cybula M, Bryl E, Smolenska Z, Jozwik A. Klotho--a common link in physiological and rheumatoid arthritis-related aging of human CD4+ lymphocytes. J Immunol. 2007;178:771-7 pubmed
    ..Underlying cellular mechanism(s) of these similarities are so far largely unknown. Here we show that KLOTHO, a beta-glucuronidase gene whose activity changes are associated with aging phenotype, is down-regulated at the ..
  47. Karalliedde J, Maltese G, Hill B, Viberti G, Gnudi L. Effect of renin-angiotensin system blockade on soluble Klotho in patients with type 2 diabetes, systolic hypertension, and albuminuria. Clin J Am Soc Nephrol. 2013;8:1899-905 pubmed publisher
    Soluble Klotho is an anti-aging phosphaturic protein associated with vascular-renal protection. In vitro and in vivo studies have demonstrated that renin-angiotensin system (RAS) blockade increases soluble Klotho levels...
  48. Matsumura Y, Aizawa H, Shiraki Iida T, Nagai R, Kuro O M, Nabeshima Y. Identification of the human klotho gene and its two transcripts encoding membrane and secreted klotho protein. Biochem Biophys Res Commun. 1998;242:626-30 pubmed
    Inactivation of the klotho (kl) gene in mice results in multiple disorders that resemble human aging. The mouse kl gene encodes a novel single-pass membrane protein with homology to beta-glucosidases...
  49. Arking D, Krebsova A, Macek M, Arking A, Mian I, Fried L, et al. Association of human aging with a functional variant of klotho. Proc Natl Acad Sci U S A. 2002;99:856-61 pubmed
    Mice deficient in Klotho gene expression exhibit a syndrome resembling premature human aging...
  50. Yokoyama K, Imura A, Ohkido I, Maruyama Y, Yamazaki Y, Hasegawa H, et al. Serum soluble ?-klotho in hemodialysis patients. Clin Nephrol. 2012;77:347-51 pubmed
    The extracellular domain of klotho is cleaved and released into various extracellular fluids, such as blood, urine, and cerebrospinal fluid, as soluble ?-klotho (s?Kl)...
  51. Urakawa I, Yamazaki Y, Shimada T, Iijima K, Hasegawa H, Okawa K, et al. Klotho converts canonical FGF receptor into a specific receptor for FGF23. Nature. 2006;444:770-4 pubmed
    ..Here we show that a previously undescribed receptor conversion by Klotho, a senescence-related molecule, generates the FGF23 receptor...
  52. Laitman Y, Kuchenbaecker K, Rantala J, Hogervorst F, Peock S, Godwin A, et al. The KL-VS sequence variant of Klotho and cancer risk in BRCA1 and BRCA2 mutation carriers. Breast Cancer Res Treat. 2012;132:1119-26 pubmed publisher
    b>Klotho (KL) is a putative tumor suppressor gene in breast and pancreatic cancers located at chromosome 13q12...
  53. Aviel Ronen S, Rubinek T, Zadok O, Vituri A, Avivi C, Wolf I, et al. Klotho expression in cervical cancer: differential expression in adenocarcinoma and squamous cell carcinoma. J Clin Pathol. 2016;69:53-7 pubmed publisher
    b>Klotho is a trans-membrane protein that serves as a tumour suppressor in a wide array of malignancies. Recent data suggest it as an epigenetically silenced tumour suppressor in cervical cancer...
  54. Dai D, Wang Q, Li X, Liu J, Ma X, Xu W. Klotho inhibits human follicular thyroid cancer cell growth and promotes apoptosis through regulation of the expression of stanniocalcin-1. Oncol Rep. 2016;35:552-8 pubmed publisher
    The new anti-aging gene Klotho has been identified as a multi-functional humoral factor which influences multiple biological processes, including tumor progression...
  55. Keles N, Dogan B, Kalçık M, Caliskan M, Keles N, Aksu F, et al. Is serum Klotho protective against atherosclerosis in patients with type 1 diabetes mellitus?. J Diabetes Complications. 2016;30:126-32 pubmed publisher
    b>Klotho deficiency is associated with several metabolic disorders...
  56. Jin S, Zhang Y, Chen Z, Qian D, Qine Y, Yongjie Q, et al. Epigenetic changes of the Klotho gene in age-related cataracts. Eur Rev Med Pharmacol Sci. 2015;19:2544-53 pubmed
    To determine the mRNA and protein expression, and methylation levels of the Klotho in lens epithelial cells (LECs) of normal transparent lenses and age-related cataracts (ARCs), and to explore the role of epigenetic changes of the Klotho ..
  57. Sun H, Gao Y, Lu K, Zhao G, Li X, Li Z, et al. Overexpression of Klotho suppresses liver cancer progression and induces cell apoptosis by negatively regulating wnt/β-catenin signaling pathway. World J Surg Oncol. 2015;13:307 pubmed publisher
    b>Klotho is a discovered aging suppressor gene, and its overexpression in mice extends the life span of the animal...
  58. Gürel A, Ãœre Ä, Temel H, Çilingir O, Uslu S, Celayir M, et al. The impact of klotho gene polymorphisms on urinary tract stone disease. World J Urol. 2016;34:1045-50 pubmed publisher
    To investigate the effect of klotho gene and β-glucuronidase activity on stone formation in patients with urinary tract stone disease (UTSD)...
  59. Wolf I, Laitman Y, Rubinek T, Abramovitz L, Novikov I, Beeri R, et al. Functional variant of KLOTHO: a breast cancer risk modifier among BRCA1 mutation carriers of Ashkenazi origin. Oncogene. 2010;29:26-33 pubmed publisher
    b>Klotho is a transmembrane protein that can be shed and act as a circulating hormone and is a putative tumor suppressor in breast cancer...
  60. Goetz R, Beenken A, Ibrahimi O, Kalinina J, Olsen S, Eliseenkova A, et al. Molecular insights into the klotho-dependent, endocrine mode of action of fibroblast growth factor 19 subfamily members. Mol Cell Biol. 2007;27:3417-28 pubmed
    ..These FGFs require the presence of Klotho/betaKlotho in their target tissues...
  61. Latus J, Lehmann R, Roesel M, Fritz P, Braun N, Ulmer C, et al. Involvement of ?-klotho, fibroblast growth factor-, vitamin-D- and calcium-sensing receptor in 53 patients with primary hyperparathyroidism. Endocrine. 2013;44:255-63 pubmed publisher
    ..calcium-sensing receptor (CaSR), vitamin D receptor (VDR), and fibroblast growth factor receptor (FGFR)/klotho complexes seem to be involved in the development of pHPT...
  62. Giroux S, Elfassihi L, Clément V, Bussières J, Bureau A, Cole D, et al. High-density polymorphisms analysis of 23 candidate genes for association with bone mineral density. Bone. 2010;47:975-81 pubmed publisher
    ..The results reported in this study suggest a role for CSF3R in the determination of bone density in women. ..
  63. Tartaglione L, Pasquali M, Rotondi S, Muci M, Leonangeli C, Farcomeni A, et al. Interactions of sclerostin with FGF23, soluble klotho and vitamin D in renal transplantation. PLoS ONE. 2017;12:e0178637 pubmed publisher
    ..with eGFR, Calcium, Phosphate, Alkaline Phosphatase (AP), intact Parathyroid hormone (iPTH), soluble alpha-Klotho (sKlotho), intact Fibroblast Growth Factor 23 (iFGF23), 25-hydroxyvitamin D(25D) and 1,25-dihydroxyvitamin D (1,..
  64. Jeong S, Song J, Kim S, Kim H, Ku N, Han S, et al. Plasma klotho levels were inversely associated with subclinical carotid atherosclerosis in HIV-infected patients receiving combined antiretroviral therapy. AIDS Res Hum Retroviruses. 2013;29:1575-81 pubmed publisher
    ..b>Klotho is a novel antiaging gene that encodes a protein with pleiotropic functions, including an emerging role in ..
  65. Zhang W, Xue D, Hu D, Xie T, Tao Y, Zhu T, et al. Secreted klotho protein attenuates osteogenic differentiation of human bone marrow mesenchymal stem cells in vitro via inactivation of the FGFR1/ERK signaling pathway. Growth Factors. 2015;33:356-65 pubmed publisher
    ..Therefore, it is essential to understand the microenvironment that regulates these processes. The Klotho gene plays an important role in tissue mineralization, and its secreted protein functions as a hormone...
  66. Teocchi M, Ferreira A, da Luz de Oliveira E, Tedeschi H, D Souza Li L. Hippocampal gene expression dysregulation of Klotho, nuclear factor kappa B and tumor necrosis factor in temporal lobe epilepsy patients. J Neuroinflammation. 2013;10:53 pubmed publisher
    ..Recently, it has been demonstrated that TNF downregulates Klotho (KL) through the nuclear factor kappa B (NFkB) system in animal models of chronic kidney disease and colitis...
  67. Cheng C, Kuro O M, Razzaque M. Molecular regulation of phosphate metabolism by fibroblast growth factor-23-klotho system. Adv Chronic Kidney Dis. 2011;18:91-7 pubmed publisher
    ..metabolism is a complex multiorgan process, and the identification of fibroblast growth factor-23 (FGF23)-Klotho system as a potent phosphatonin has provided new mechanistic insights into the homeostatic control of phosphate...
  68. Mazzotta C, Manetti M, Rosa I, Romano E, Blagojevic J, Bellando Randone S, et al. Proangiogenic effects of soluble ?-Klotho on systemic sclerosis dermal microvascular endothelial cells. Arthritis Res Ther. 2017;19:27 pubmed publisher
    ..Soluble ?-Klotho (sKl) is a pleiotropic molecule with multiple effects on ECs, including antioxidant and vasculoprotective ..
  69. Carracedo J, Buendia P, Merino A, Madueño J, Peralbo E, Ortiz A, et al. Klotho modulates the stress response in human senescent endothelial cells. Mech Ageing Dev. 2012;133:647-54 pubmed publisher
    Lack of Klotho expression in mice leads to premature aging and age-related diseases, including vascular diseases...
  70. Gan L, Pan J, Chen S, Zhong J, Wang L. [DNA methylation of ZIC1 and KLOTHO gene promoters in colorectal carcinomas and its clinicopathological significance]. Zhejiang Da Xue Xue Bao Yi Xue Ban. 2011;40:309-14 pubmed
    To determine DNA methylation status of ZIC1 and KLOTHO gene in colorectal carcinomas and its relationship with clinicopathological features of patients...
  71. Richter B, Haller J, Haffner D, Leifheit Nestler M. Klotho modulates FGF23-mediated NO synthesis and oxidative stress in human coronary artery endothelial cells. Pflugers Arch. 2016;468:1621-35 pubmed publisher
    Chronic kidney disease (CKD) is a state of Klotho deficiency and excess of the phosphaturic hormone fibroblast growth factor 23 (FGF23)...