Gene Symbol: IL9R
Description: interleukin 9 receptor
Alias: CD129, IL-9R, interleukin-9 receptor, IL-9 receptor
Species: human
Products:     IL9R

Top Publications

  1. Levitt R, McLane M, MacDonald D, Ferrante V, Weiss C, Zhou T, et al. IL-9 pathway in asthma: new therapeutic targets for allergic inflammatory disorders. J Allergy Clin Immunol. 1999;103:S485-91 pubmed
    ..These data support a central role for the IL-9 pathway in the complex pathogenesis of allergic inflammation. ..
  2. Chen J, Petrus M, Bryant B, Phuc Nguyen V, Stamer M, Goldman C, et al. Induction of the IL-9 gene by HTLV-I Tax stimulates the spontaneous proliferation of primary adult T-cell leukemia cells by a paracrine mechanism. Blood. 2008;111:5163-72 pubmed publisher
    ..In summary, these data support a role for IL-9 and its receptor in ATL by a paracrine mechanism...
  3. McCanlies E, Yucesoy B, Mnatsakanova A, Slaven J, Andrew M, Frye B, et al. Association between IL-1A single nucleotide polymorphisms and chronic beryllium disease and beryllium sensitization. J Occup Environ Med. 2010;52:680-4 pubmed publisher
    ..To determine if single nucleotide polymorphisms (SNPs) in interleukin (IL) IL-1A, IL-1B, IL-1RN, IL-2, IL-9, and IL-9R were associated with chronic beryllium disease (CBD) and beryllium sensitization (BeS)...
  4. Knoops L, Renauld J. IL-9 and its receptor: from signal transduction to tumorigenesis. Growth Factors. 2004;22:207-15 pubmed
    ..Moreover, in vitro, dysregulated IL-9 response can lead to autonomous cell growth and malignant transformation of lymphoid cells associated with constitutive activation of the Jak/STAT pathway. ..
  5. Purwar R, Schlapbach C, Xiao S, Kang H, Elyaman W, Jiang X, et al. Robust tumor immunity to melanoma mediated by interleukin-9-producing T cells. Nat Med. 2012;18:1248-53 pubmed publisher
    ..IL-9-blocking antibodies reversed this tumor growth inhibition and enhanced tumor growth in wild-type (WT) mice. Il9r(-/-) mice showed accelerated tumor growth, and administration of recombinant IL-9 (rIL-9) to tumor-bearing WT and ..
  6. Tompa A, Nilsson Bowers A, Faresjö M. Subsets of CD4+, CD8+, and CD25hi Lymphocytes Are in General Not Influenced by Isolation and Long-Term Cryopreservation. J Immunol. 2018;201:1799-1809 pubmed publisher
    ..The percentages of Treg cells defined as CD4+CD25hi expressing CD101 or CD129, CD4+CD25hiCD127-, and CD4+CD25hiCD127-FOXP3..
  7. Scripture Adams D, Damle S, Li L, Elihu K, Qin S, Arias A, et al. GATA-3 dose-dependent checkpoints in early T cell commitment. J Immunol. 2014;193:3470-91 pubmed publisher
    ..1) and Bcl11a, and downregulated genes, including Cpa3, Ets1, Zfpm1, Bcl11b, Il9r, and Il17rb with gene-specific kinetics and dose dependencies...
  8. Castro A, Rodríguez F, Flórez M, López P, Curotto B, Martínez D, et al. Pseudoautosomal abnormalities in terminal AZFb+c deletions are associated with isochromosomes Yp and may lead to abnormal growth and neuropsychiatric function. Hum Reprod. 2017;32:465-475 pubmed publisher
    ..ligation-dependent probe amplification (MLPA), followed by qPCR analysis for genes in PAR1 (SHOX and ZBED1), PAR2 (IL9R) and two single copy genes (SRY and DDX3Y, respectively located in Yp11.3 and AZFa)...
  9. Vieyra Garcia P, Wei T, Naym D, Fredholm S, Fink Puches R, Cerroni L, et al. STAT3/5-Dependent IL9 Overexpression Contributes to Neoplastic Cell Survival in Mycosis Fungoides. Clin Cancer Res. 2016;22:3328-39 pubmed publisher
    ..PUVA or UVB phototherapy diminished the frequencies of IL9- and IL9r-positive cells, as well as STAT3/5a and IRF4 expression in lesional skin...

More Information


  1. Fawaz L, Sharif Askari E, Hajoui O, Soussi Gounni A, Hamid Q, Mazer B. Expression of IL-9 receptor alpha chain on human germinal center B cells modulates IgE secretion. J Allergy Clin Immunol. 2007;120:1208-15 pubmed
    ..IL-9 appears to be involved in memory B-cell differentiation and T(H)2-mediated allergic diseases such as asthma. ..
  2. Åkesson K, Tompa A, Rydén A, Faresjö M. Low expression of CD39(+) /CD45RA(+) on regulatory T cells (Treg ) cells in type 1 diabetic children in contrast to high expression of CD101(+) /CD129(+) on Treg cells in children with coeliac disease. Clin Exp Immunol. 2015;180:70-82 pubmed publisher
    ..CCR7(-) ) and Treg (CD4(+) CD25(+) FOXP3(+) CD127(-) ) cells, and their expression of CD39, CD45RA, CD101 and CD129, were studied by flow cytometry in T1D and/or coeliac disease children or without any of these diseases (reference ..
  3. Gerlach K, Hwang Y, Nikolaev A, Atreya R, Dornhoff H, Steiner S, et al. TH9 cells that express the transcription factor PU.1 drive T cell-mediated colitis via IL-9 receptor signaling in intestinal epithelial cells. Nat Immunol. 2014;15:676-86 pubmed publisher
  4. Namkung J, Lee J, Kim E, Park G, Yang H, Jang H, et al. An association between IL-9 and IL-9 receptor gene polymorphisms and atopic dermatitis in a Korean population. J Dermatol Sci. 2011;62:16-21 pubmed publisher
    ..As the classes of helper T cells are diverse and the function of IL-9 cytokine has not been fully described, the cutaneous function of IL-9 needs to be further explored in future studies. ..
  5. Burkhardt J, Petit Teixeira E, Teixeira V, Kirsten H, Garnier S, Ruehle S, et al. Association of the X-chromosomal genes TIMP1 and IL9R with rheumatoid arthritis. J Rheumatol. 2009;36:2149-57 pubmed publisher
    ..In combined analysis of sets 1 and 2, evidence remained for association of 3 SNP in the genes UBA1, TIMP1, and IL9R. These were again genotyped in the third sample set...
  6. Dragon S, Takhar M, Shan L, Hayglass K, Simons F, Gounni A. T(H)2 cytokines modulate the IL-9R expression on human neutrophils. Biochem Biophys Res Commun. 2009;384:167-72 pubmed publisher
    ..Collectively, our results reveal a regulatory function for IFN-gamma and IL-10 on modulating the inducible IL-9Ralpha expression levels on peripheral blood neutrophils by T(H)2 cytokines. ..
  7. Hornakova T, Staerk J, Royer Y, Flex E, Tartaglia M, Constantinescu S, et al. Acute lymphoblastic leukemia-associated JAK1 mutants activate the Janus kinase/STAT pathway via interleukin-9 receptor alpha homodimers. J Biol Chem. 2009;284:6773-81 pubmed publisher
    ..Similar results were observed with IL-2Rbeta. Taken together, our results show that IL-9Ralpha and IL-2Rbeta homodimers efficiently mediate constitutive activation of ALL-associated JAK1 mutants. ..
  8. Melen E, Umerkajeff S, Nyberg F, Zucchelli M, Lindstedt A, Gullsten H, et al. Interaction between variants in the interleukin-4 receptor alpha and interleukin-9 receptor genes in childhood wheezing: evidence from a birth cohort study. Clin Exp Allergy. 2006;36:1391-8 pubmed
    ..departure from a multiplicative interaction model) between the IL4RA SNPs and four SNPs in the IL-9 receptor (IL9R) gene previously associated with childhood wheezing...
  9. Kermouni A, Van Roost E, Arden K, Vermeesch J, Weiss S, Godelaine D, et al. The IL-9 receptor gene (IL9R): genomic structure, chromosomal localization in the pseudoautosomal region of the long arm of the sex chromosomes, and identification of IL9R pseudogenes at 9qter, 10pter, 16pter, and 18pter. Genomics. 1995;29:371-82 pubmed
    Cosmids containing the human IL-9 receptor (R) gene (IL9R) have been isolated from a genomic library using the IL9R cDNA as a probe. We have shown that the human IL9R cDNA as a probe...
  10. Abdelilah S, Latifa K, Esra N, Cameron L, Bouchaib L, Nicolaides N, et al. Functional expression of IL-9 receptor by human neutrophils from asthmatic donors: role in IL-8 release. J Immunol. 2001;166:2768-74 pubmed
    ..Taken together, these findings suggest a novel role for PMNs in allergic disease through the expression and activation of the IL-9R. ..
  11. De Smedt M, Verhasselt B, Kerre T, Vanhecke D, Naessens E, Leclercq G, et al. Signals from the IL-9 receptor are critical for the early stages of human intrathymic T cell development. J Immunol. 2000;164:1761-7 pubmed
    ..Addition of IL-9 to the FTOC resulted in an increase in cell number, without disturbing the frequencies of the different subsets. These data suggest that IL-9Ralpha signaling is critical in early T lymphoid development. ..
  12. Sliva D, Zhu Y, Tsai S, Kamine J, Yang Y. Tip60 interacts with human interleukin-9 receptor alpha-chain. Biochem Biophys Res Commun. 1999;263:149-55 pubmed
    ..Our results therefore suggest that Tip60 may act as a cofactor of Stat3 or as an adaptor protein for molecules that are important for IL-9 signaling. ..
  13. Kimura Y, Takeshita T, Kondo M, Ishii N, Nakamura M, Van Snick J, et al. Sharing of the IL-2 receptor gamma chain with the functional IL-9 receptor complex. Int Immunol. 1995;7:115-20 pubmed
    ..These results demonstrate that the gamma c chain is included in the functional receptor complex for IL-9, which was initially characterized as a T cell growth factor and is essential for IL-9-dependent growth signal transduction. ..
  14. Chang M, Engel G, Benedict C, Basu R, McNinch J. Isolation and characterization of the human interleukin-9 receptor gene. Blood. 1994;83:3199-205 pubmed
  15. Li H, Sun Q, Liu L, Zhang J, Huang J, Wang C, et al. High expression of IL-9R promotes the progression of human hepatocellular carcinoma and indicates a poor clinical outcome. Oncol Rep. 2015;34:795-802 pubmed publisher
    ..018). The findings indicated that IL-9R was constitutively expressed and exerted a tumor-promoting effect in HCC, whose expression level may be a useful biomarker of tumor invasiveness and patient clinical outcome. ..
  16. Demoulin J, Uyttenhove C, Van Roost E, DeLestré B, Donckers D, Van Snick J, et al. A single tyrosine of the interleukin-9 (IL-9) receptor is required for STAT activation, antiapoptotic activity, and growth regulation by IL-9. Mol Cell Biol. 1996;16:4710-6 pubmed
    ..Taken together, these data indicate that a single tyrosine of the IL-9 receptor, required for activation of three different STAT proteins, is necessary for distinct activities of this cytokine, including proliferative responses. ..
  17. Nizsalóczki E, Csomós I, Nagy P, Fazekas Z, Goldman C, Waldmann T, et al. Distinct spatial relationship of the interleukin-9 receptor with interleukin-2 receptor and major histocompatibility complex glycoproteins in human T lymphoma cells. Chemphyschem. 2014;15:3969-78 pubmed publisher
    ..Our data indicate that co-compartmentalization with MHC glycoproteins is a general property of γ(c) receptors. Distribution of receptor chains between different membrane domains may regulate their function. ..
  18. Vermeesch J, Petit P, Kermouni A, Renauld J, Van den Berghe H, Marynen P. The IL-9 receptor gene, located in the Xq/Yq pseudoautosomal region, has an autosomal origin, escapes X inactivation and is expressed from the Y. Hum Mol Genet. 1997;6:1-8 pubmed
    ..We show that the interleukin-9 (IL-9) receptor gene (IL9R), which is located within the human Xq/Yq homology region, maps to the murine chromosome 11...
  19. Bauer J, Liu K, You Y, Lai S, Goldsmith M. Heteromerization of the gammac chain with the interleukin-9 receptor alpha subunit leads to STAT activation and prevention of apoptosis. J Biol Chem. 1998;273:9255-60 pubmed
    ..Nonetheless, these T cells are efficiently protected from dexamethasone-induced apoptosis. These results further define the molecular architecture of the IL-9R and its specific connections to various biologic responses. ..
  20. Lv X, Feng L, Fang X, Jiang Y, Wang X. Overexpression of IL-9 receptor in diffuse large B-cell lymphoma. Int J Clin Exp Pathol. 2013;6:911-6 pubmed
    ..Our findings suggest that overexpression of IL-9R may contribute to the pathogenesis of DLBCL and is associated with some adverse prognostic parameters. ..
  21. Kobayashi H, Kumai T, Hayashi S, Matsuda Y, Aoki N, Sato K, et al. A naturally processed HLA-DR-bound peptide from the IL-9 receptor alpha of HTLV-1-transformed T cells serves as a T helper epitope. Cancer Immunol Immunother. 2012;61:2215-25 pubmed publisher
  22. Little F, Cruikshank W, Center D. Il-9 stimulates release of chemotactic factors from human bronchial epithelial cells. Am J Respir Cell Mol Biol. 2001;25:347-52 pubmed
    ..We conclude that IL-9 is a stimulus for airway epithelial cell release of T-cell chemoattractant factors, which in turn may modulate the immune response in allergic airway inflammation. ..
  23. Nowak E, Weaver C, Turner H, Begum Haque S, Becher B, Schreiner B, et al. IL-9 as a mediator of Th17-driven inflammatory disease. J Exp Med. 2009;206:1653-60 pubmed publisher
    ..Collectively, these data implicate IL-9 as a Th17-derived cytokine that can contribute to inflammatory disease...
  24. Malka Y, Hornakova T, Royer Y, Knoops L, Renauld J, Constantinescu S, et al. Ligand-independent homomeric and heteromeric complexes between interleukin-2 or -9 receptor subunits and the gamma chain. J Biol Chem. 2008;283:33569-77 pubmed publisher
  25. Kauppi P, Laitinen T, Ollikainen V, Mannila H, Laitinen L, Kere J. The IL9R region contribution in asthma is supported by genetic association in an isolated population. Eur J Hum Genet. 2000;8:788-92 pubmed
    ..5q cytokine cluster did not support a genetic role for the IL9 gene, we became interested in the IL9 receptor gene (IL9R) in the pseudoautosomal region...
  26. Renauld J, Druez C, Kermouni A, Houssiau F, Uyttenhove C, Van Roost E, et al. Expression cloning of the murine and human interleukin 9 receptor cDNAs. Proc Natl Acad Sci U S A. 1992;89:5690-4 pubmed
    ..Sequence analysis revealed that the IL-9 receptor belongs to the recently described hematopoietin receptor super-family and is expressed in membrane-bound and soluble forms. ..
  27. Asao H, Okuyama C, Kumaki S, Ishii N, Tsuchiya S, Foster D, et al. Cutting edge: the common gamma-chain is an indispensable subunit of the IL-21 receptor complex. J Immunol. 2001;167:1-5 pubmed
    ..The chemical cross-linking study reveals the direct binding of IL-21 to the gamma(c). These data clearly demonstrate that the gamma(c) is an indispensable subunit of the functional IL-21R complex. ..
  28. Melen E, Gullsten H, Zucchelli M, Lindstedt A, Nyberg F, Wickman M, et al. Sex specific protective effects of interleukin-9 receptor haplotypes on childhood wheezing and sensitisation. J Med Genet. 2004;41:e123 pubmed
  29. Gounni A, Hamid Q, Rahman S, Hoeck J, Yang J, Shan L. IL-9-mediated induction of eotaxin1/CCL11 in human airway smooth muscle cells. J Immunol. 2004;173:2771-9 pubmed
    ..Taken together, these data provide new evidence demonstrating that IL-9-dependent activation of ASM cells contributes to eosinophilic inflammation observed in asthma. ..
  30. Sliva D, Gu M, Zhu Y, Chen J, Tsai S, Du X, et al. 14-3-3zeta interacts with the alpha-chain of human interleukin 9 receptor. Biochem J. 2000;345 Pt 3:741-7 pubmed
    ..The interaction between 14-3-3 and IL-9Ralpha but not IL-4Ralpha also suggests a potential role for 14-3-3 in determining cytokine specificity. ..
  31. Ciccodicola A, D ESPOSITO M, Esposito T, Gianfrancesco F, Migliaccio C, Miano M, et al. Differentially regulated and evolved genes in the fully sequenced Xq/Yq pseudoautosomal region. Hum Mol Genet. 2000;9:395-401 pubmed
    ..The GC-rich distal 35 kb, added in stages and much later in evolution, contains the X/Y expressed gene IL9R and a novel gene, CXYorf1, only 5 kb from the Xq telomere...
  32. Lv X, Feng L, Ge X, Lu K, Wang X. Interleukin-9 promotes cell survival and drug resistance in diffuse large B-cell lymphoma. J Exp Clin Cancer Res. 2016;35:106 pubmed publisher
    ..IL-9 is associated with clinical features of DLBCL patients. It promotes survival of DLBCL cells and reduces the sensitivities of tumor cells to chemotherapeutic drugs via upregulation of p21CIP1 genes. ..
  33. Guggino G, Ciccia F, Di Liberto D, Lo Pizzo M, Ruscitti P, Cipriani P, et al. Interleukin (IL)-9/IL-9R axis drives ?? T cells activation in psoriatic arthritis patients. Clin Exp Immunol. 2016;186:277-283 pubmed publisher
    ..Moreover, in PsA patients ?? T cells activation is driven prevalently by IL-9/IL-9R interaction, and not only by IL-23/IL-23R. Together these findings indicate ?? T cells and IL-9 as new players in the pathogenesis of PsA. ..
  34. Tsukadaira A, Okubo Y, Koyama S, Sato E, Nagase H, Agematsu K, et al. Human bronchial epithelium expresses interleukin-9 receptors and releases neutrophil chemotactic factor. Exp Lung Res. 2002;28:123-39 pubmed
    ..The components of the IL-9 receptor, consisting of IL-9 receptor alpha (CD129) and IL-2 receptory ((1)132), were expressed on BEAS-2B cells as determined by RT-PCR and flow cytometry...