IL2RG

Summary

Gene Symbol: IL2RG
Description: interleukin 2 receptor subunit gamma
Alias: CD132, CIDX, IL-2RG, IMD4, P64, SCIDX, SCIDX1, cytokine receptor common subunit gamma, CD132 antigen, IL-2 receptor subunit gamma, IL-2R subunit gamma, common cytokine receptor gamma chain, gammaC, interleukin 2 receptor, gamma
Species: human
Products:     IL2RG

Top Publications

  1. Bamborough P, Hedgecock C, Richards W. The interleukin-2 and interleukin-4 receptors studied by molecular modelling. Structure. 1994;2:839-51 pubmed
    ..In addition, they may be of use in the identification of residues which may interact in the ligand-receptor interfaces, and which would therefore be worthy of further investigation. ..
  2. Noguchi M, Nakamura Y, Russell S, Ziegler S, Tsang M, Cao X, et al. Interleukin-2 receptor gamma chain: a functional component of the interleukin-7 receptor. Science. 1993;262:1877-80 pubmed
    ..These findings may help explain the defects of XSCID. Given its role in more than one cytokine receptor system, the common gamma chain (gamma c) is proposed as the designation for IL-2R gamma. ..
  3. Rose T, Lambotte O, Pallier C, Delfraissy J, Colle J. Identification and biochemical characterization of human plasma soluble IL-7R: lower concentrations in HIV-1-infected patients. J Immunol. 2009;182:7389-97 pubmed publisher
    ..0014) 2-fold decrease in plasma sIL-7Ralpha levels compared with those in control healthy individuals. Plasma IL-7 and sIL-7Ralpha levels did not show any obvious relationship. ..
  4. Giri J, Kumaki S, Ahdieh M, Friend D, Loomis A, Shanebeck K, et al. Identification and cloning of a novel IL-15 binding protein that is structurally related to the alpha chain of the IL-2 receptor. EMBO J. 1995;14:3654-63 pubmed
    ..IL-15R alpha is structurally similar to IL-2R alpha; together they define a new cytokine receptor family. The distribution of IL-15 and IL-15R alpha mRNA suggests that IL-15 may have biological activities distinct from IL-2. ..
  5. Stauber D, Debler E, Horton P, Smith K, Wilson I. Crystal structure of the IL-2 signaling complex: paradigm for a heterotrimeric cytokine receptor. Proc Natl Acad Sci U S A. 2006;103:2788-93 pubmed
    ..The IL-2/gamma(c) interface itself exhibits the smallest buried surface and the fewest hydrogen bonds in the complex, which is consistent with its promiscuous use in other cytokine receptor complexes. ..
  6. Takeshita T, Asao H, Ohtani K, Ishii N, Kumaki S, Tanaka N, et al. Cloning of the gamma chain of the human IL-2 receptor. Science. 1992;257:379-82 pubmed
    ..Thus, the gamma chain is an indispensable component of the functional IL-2R. ..
  7. Russell S, Johnston J, Noguchi M, Kawamura M, Bacon C, Friedmann M, et al. Interaction of IL-2R beta and gamma c chains with Jak1 and Jak3: implications for XSCID and XCID. Science. 1994;266:1042-5 pubmed
    ..Thus, gamma c mutations in at least some XSCID and XCID patients prevent normal Jak3 activation, suggesting that mutations of Jak3 may result in an XSCID-like phenotype. ..
  8. García Tuñón I, Ricote M, Ruiz A, Fraile B, Paniagua R, Royuela M. Interleukin-2 and its receptor complex (alpha, beta and gamma chains) in in situ and infiltrative human breast cancer: an immunohistochemical comparative study. Breast Cancer Res. 2004;6:R1-7 pubmed
    ..The development of breast tumour is associated with an increased expression of IL-2 and its three receptor chains, and this expression also seems to be associated with the malignancy of the tumour. ..
  9. Zhang J, Foster D, Sebald W. Human IL-21 and IL-4 bind to partially overlapping epitopes of common gamma-chain. Biochem Biophys Res Commun. 2003;300:291-6 pubmed
    ..These results open the way to understand the molecular recognition mechanism in the IL-21 receptor system and also the promiscuous binding properties of gamma(c). ..
  10. Kondo M, Takeshita T, Ishii N, Nakamura M, Watanabe S, Arai K, et al. Sharing of the interleukin-2 (IL-2) receptor gamma chain between receptors for IL-2 and IL-4. Science. 1993;262:1874-7 pubmed
    ..These results suggest that the IL-2 receptor gamma chain is functionally involved in the IL-4 receptor complex. ..

Detail Information

Publications62

  1. Bamborough P, Hedgecock C, Richards W. The interleukin-2 and interleukin-4 receptors studied by molecular modelling. Structure. 1994;2:839-51 pubmed
    ..In addition, they may be of use in the identification of residues which may interact in the ligand-receptor interfaces, and which would therefore be worthy of further investigation. ..
  2. Noguchi M, Nakamura Y, Russell S, Ziegler S, Tsang M, Cao X, et al. Interleukin-2 receptor gamma chain: a functional component of the interleukin-7 receptor. Science. 1993;262:1877-80 pubmed
    ..These findings may help explain the defects of XSCID. Given its role in more than one cytokine receptor system, the common gamma chain (gamma c) is proposed as the designation for IL-2R gamma. ..
  3. Rose T, Lambotte O, Pallier C, Delfraissy J, Colle J. Identification and biochemical characterization of human plasma soluble IL-7R: lower concentrations in HIV-1-infected patients. J Immunol. 2009;182:7389-97 pubmed publisher
    ..0014) 2-fold decrease in plasma sIL-7Ralpha levels compared with those in control healthy individuals. Plasma IL-7 and sIL-7Ralpha levels did not show any obvious relationship. ..
  4. Giri J, Kumaki S, Ahdieh M, Friend D, Loomis A, Shanebeck K, et al. Identification and cloning of a novel IL-15 binding protein that is structurally related to the alpha chain of the IL-2 receptor. EMBO J. 1995;14:3654-63 pubmed
    ..IL-15R alpha is structurally similar to IL-2R alpha; together they define a new cytokine receptor family. The distribution of IL-15 and IL-15R alpha mRNA suggests that IL-15 may have biological activities distinct from IL-2. ..
  5. Stauber D, Debler E, Horton P, Smith K, Wilson I. Crystal structure of the IL-2 signaling complex: paradigm for a heterotrimeric cytokine receptor. Proc Natl Acad Sci U S A. 2006;103:2788-93 pubmed
    ..The IL-2/gamma(c) interface itself exhibits the smallest buried surface and the fewest hydrogen bonds in the complex, which is consistent with its promiscuous use in other cytokine receptor complexes. ..
  6. Takeshita T, Asao H, Ohtani K, Ishii N, Kumaki S, Tanaka N, et al. Cloning of the gamma chain of the human IL-2 receptor. Science. 1992;257:379-82 pubmed
    ..Thus, the gamma chain is an indispensable component of the functional IL-2R. ..
  7. Russell S, Johnston J, Noguchi M, Kawamura M, Bacon C, Friedmann M, et al. Interaction of IL-2R beta and gamma c chains with Jak1 and Jak3: implications for XSCID and XCID. Science. 1994;266:1042-5 pubmed
    ..Thus, gamma c mutations in at least some XSCID and XCID patients prevent normal Jak3 activation, suggesting that mutations of Jak3 may result in an XSCID-like phenotype. ..
  8. García Tuñón I, Ricote M, Ruiz A, Fraile B, Paniagua R, Royuela M. Interleukin-2 and its receptor complex (alpha, beta and gamma chains) in in situ and infiltrative human breast cancer: an immunohistochemical comparative study. Breast Cancer Res. 2004;6:R1-7 pubmed
    ..The development of breast tumour is associated with an increased expression of IL-2 and its three receptor chains, and this expression also seems to be associated with the malignancy of the tumour. ..
  9. Zhang J, Foster D, Sebald W. Human IL-21 and IL-4 bind to partially overlapping epitopes of common gamma-chain. Biochem Biophys Res Commun. 2003;300:291-6 pubmed
    ..These results open the way to understand the molecular recognition mechanism in the IL-21 receptor system and also the promiscuous binding properties of gamma(c). ..
  10. Kondo M, Takeshita T, Ishii N, Nakamura M, Watanabe S, Arai K, et al. Sharing of the interleukin-2 (IL-2) receptor gamma chain between receptors for IL-2 and IL-4. Science. 1993;262:1874-7 pubmed
    ..These results suggest that the IL-2 receptor gamma chain is functionally involved in the IL-4 receptor complex. ..
  11. Russell S, Keegan A, Harada N, Nakamura Y, Noguchi M, Leland P, et al. Interleukin-2 receptor gamma chain: a functional component of the interleukin-4 receptor. Science. 1993;262:1880-3 pubmed
    ....
  12. Cosenza L, Gorgun G, Urbano A, Foss F. Interleukin-7 receptor expression and activation in nonhaematopoietic neoplastic cell lines. Cell Signal. 2002;14:317-25 pubmed
    ..The expression of functional IL-7R on epithelial tumour cells may represent a potential target for receptor-directed therapy. ..
  13. Ellery J, Nicholls P. Alternate signalling pathways from the interleukin-2 receptor. Cytokine Growth Factor Rev. 2002;13:27-40 pubmed
    ..This review intends to suggest a role for these differences within the context of the immune system. ..
  14. Wang X, Rickert M, Garcia K. Structure of the quaternary complex of interleukin-2 with its alpha, beta, and gammac receptors. Science. 2005;310:1159-63 pubmed
    ..3 angstroms, the binding of IL-2Ralpha to IL-2 stabilizes a secondary binding site for presentation to IL-2Rbeta. gammac is then recruited to the composite surface formed by the IL-2/IL-2Rbeta complex...
  15. Puck J, Deschenes S, Porter J, Dutra A, Brown C, Willard H, et al. The interleukin-2 receptor gamma chain maps to Xq13.1 and is mutated in X-linked severe combined immunodeficiency, SCIDX1. Hum Mol Genet. 1993;2:1099-104 pubmed
    ..We considered this gene, IL2RG, a candidate for the X-linked form of severe combined immunodeficiency at the SCIDX1 locus, in which affected males have impaired lymphocyte development...
  16. Bai Q, Liu N, Kong X, Xu X, Zhao Z. Mutation analyses and prenatal diagnosis in families of X-linked severe combined immunodeficiency caused by IL2Rγ gene novel mutation. Genet Mol Res. 2015;14:6164-72 pubmed publisher
    ..In couples with an X-SCID reproductive history, prenatal gene mutation analysis of IL2Rγ can effectively prevent the birth of children with X-SCID and carrier detection for suspected females. ..
  17. Adriani M, Garbi C, Amodio G, Russo I, Giovannini M, Amorosi S, et al. Functional interaction of common gamma-chain and growth hormone receptor signaling apparatus. J Immunol. 2006;177:6889-95 pubmed
    ..In the present study, we examined a potential role of common cytokine receptor gamma-chain (gammac) in GHR signaling using EBV-transformed lymphocytes from healthy subjects and gammac-negative X-SCID patients...
  18. Miyazaki T, Kawahara A, Fujii H, Nakagawa Y, Minami Y, Liu Z, et al. Functional activation of Jak1 and Jak3 by selective association with IL-2 receptor subunits. Science. 1994;266:1045-7 pubmed
    ..Furthermore, Jak3-negative fibroblasts expressing reconstituted IL-2R became responsive to IL-2 after the additional expression of Jak3 complementary DNA. Thus, activation of Jak1 and Jak3 may be a key event in IL-2 signaling. ..
  19. Markiewicz S, Subtil A, Dautry Varsat A, Fischer A, de Saint Basile G. Detection of three nonsense mutations and one missense mutation in the interleukin-2 receptor gamma chain gene in SCIDX1 that differently affect the mRNA processing. Genomics. 1994;21:291-3 pubmed
  20. Seki Y, Hayashi K, Matsumoto A, Seki N, Tsukada J, Ransom J, et al. Expression of the suppressor of cytokine signaling-5 (SOCS5) negatively regulates IL-4-dependent STAT6 activation and Th2 differentiation. Proc Natl Acad Sci U S A. 2002;99:13003-8 pubmed
    ..Therefore, the induced SOCS5 protein in Th1 differentiation environment may play an important role by regulating Th1 and Th2 balance. ..
  21. Alsina L, Gonzalez Roca E, Giner M, Piquer M, Puga I, Pascal M, et al. Massively parallel sequencing reveals maternal somatic IL2RG mosaicism in an X-linked severe combined immunodeficiency family. J Allergy Clin Immunol. 2013;132:741-743.e2 pubmed publisher
  22. Okuno Y, Hoshino A, Muramatsu H, Kawashima N, Wang X, Yoshida K, et al. Late-Onset Combined Immunodeficiency with a Novel IL2RG Mutation and Probable Revertant Somatic Mosaicism. J Clin Immunol. 2015;35:610-4 pubmed publisher
    ..Whole-exome sequencing analysis identified an IL2RG p.P58T missense mutation. CD8(+) and CD56(+) cells showed revertant somatic mosaicism to the wild-type allele...
  23. Tan W, Yu S, Lei J, Wu B, Wu C. A novel common gamma chain mutation in a Chinese family with X-linked severe combined immunodeficiency (X-SCID; T(-)NK(-)B(+)). Immunogenetics. 2015;67:629-39 pubmed publisher
    ..Genomic DNA sequencing revealed that the patient had missense mutations in the IL2RG (exon 5, 718 T > C) and IL7R genes (exon 2, 197 T > C; exon 4, 412G > A)...
  24. Wang Y, Wang K, Dang N, Wang L, Zhang M. Downregulation of miR-3940-5p promotes T-cell activity by targeting the cytokine receptor IL-2R gamma on human cutaneous T-cell lines. Immunobiology. 2016;221:1378-1381 pubmed publisher
    ..According to the research findings, we hypothesized that the novel miRNA plays a potential role on human cutaneous T lymphocytes in the action mechanism of immune imbalance in vitiligo. ..
  25. Erkers T, Solders M, Verleng L, Bergström C, Stikvoort A, Rane L, et al. Frontline Science: Placenta-derived decidual stromal cells alter IL-2R expression and signaling in alloantigen-activated T cells. J Leukoc Biol. 2017;101:623-632 pubmed publisher
    ..increased by DSCs, whereas the frequency and intensity of expression of the signaling subunits CD122 (IL-2Rβ) and CD132 (IL-2Rγc) were reduced. Consequently, uptake of IL-2 and STAT5 phosphorylation (pSTAT5) was abrogated...
  26. Donnenberg V, Huber A, Basse P, Rubin J, Donnenberg A. Neither epithelial nor mesenchymal circulating tumor cells isolated from breast cancer patients are tumorigenic in NOD-scid Il2rgnull mice. NPJ Breast Cancer. 2016;2:16004 pubmed publisher
    ..Cells were injected into the mammary fat pads of NOD-scid Il2rgnull mice. The injection of very large numbers of CTCs (0.3-1...
  27. Dusseaux M, Masse Ranson G, Darche S, Ahodantin J, Li Y, Fiquet O, et al. Viral Load Affects the Immune Response to HBV in Mice With Humanized Immune System and Liver. Gastroenterology. 2017;153:1647-1661.e9 pubmed publisher
    ..We performed studies with BALB/c Rag2-/-Il2rg-/-SirpaNODAlb-uPAtg/tg mice, stably engrafted with human hepatocytes (HUHEP) with ..
  28. Noguchi M, Sarin A, Aman M, Nakajima H, Shores E, Henkart P, et al. Functional cleavage of the common cytokine receptor gamma chain (gammac) by calpain. Proc Natl Acad Sci U S A. 1997;94:11534-9 pubmed
    ..a calcium-dependent cysteine protease, was found to interact with the cytoplasmic domain of the common cytokine receptor gamma chain (gammac) in a yeast two-hybrid interaction trap assay...
  29. Hara H, Shibata H, Nakano K, Abe T, Uosaki H, Ohnuki T, et al. Production and rearing of germ-free X-SCID pigs. Exp Anim. 2017;: pubmed publisher
    ..severe combined immunodeficiency (X-SCID) caused by a mutation of the interleukin-2 receptor gamma chain gene (IL2RG) are of value for a wide range of studies...
  30. Richard E, Grellety T, Velasco V, MacGrogan G, Bonnefoi H, Iggo R. The mammary ducts create a favourable microenvironment for xenografting of luminal and molecular apocrine breast tumours. J Pathol. 2016;240:256-261 pubmed publisher
    ..with a lentiviral vector expressing tdTomato and injected through the nipple into the mammary ducts of NOD-SCID-IL2RG-/- mice...
  31. Ameratunga R, Woon S. Customised molecular diagnosis of primary immune deficiency disorders in New Zealand: an efficient strategy for a small developed country. N Z Med J. 2009;122:46-53 pubmed
    ..Family studies have been undertaken after genetic counselling. Customised genetic testing is a cost-effective and efficient method for PID diagnosis in a small developed country. ..
  32. Kuijpers T, van Leeuwen E, Barendregt B, Klarenbeek P, Aan de Kerk D, Baars P, et al. A reversion of an IL2RG mutation in combined immunodeficiency providing competitive advantage to the majority of CD8+ T cells. Haematologica. 2013;98:1030-8 pubmed publisher
    Mutations in the common gamma chain (γc, CD132, encoded by the IL2RG gene) can lead to B(+)T(-)NK(-) X-linked severe combined immunodeficiency, as a consequence of unresponsiveness to γc-cytokines such as interleukins-2, -7 and -15...
  33. Nanni P, Nicoletti G, Palladini A, Croci S, Murgo A, Ianzano M, et al. Multiorgan metastasis of human HER-2+ breast cancer in Rag2-/-;Il2rg-/- mice and treatment with PI3K inhibitor. PLoS ONE. 2012;7:e39626 pubmed publisher
    ..We describe a model system based on a highly immunodeficient double knockout mouse, Rag2-/-;Il2rg-/-, which lacks T, B and NK cell activity...
  34. Vigliano I, Palamaro L, Bianchino G, Fusco A, Vitiello L, Grieco V, et al. Role of the common γ chain in cell cycle progression of human malignant cell lines. Int Immunol. 2012;24:159-67 pubmed publisher
    ....
  35. Orr S, Roessler S, Quigley L, Chan T, Ford J, O Connor G, et al. Implications for gene therapy-limiting expression of IL-2R gamma c delineate differences in signaling thresholds required for lymphocyte development and maintenance. J Immunol. 2010;185:1393-403 pubmed publisher
    ..Further, our findings suggest that IL-2Rgamma(c) reconstituted T cells may persist more efficiently than NK cells due to compensation for suboptimal IL-2Rgamma(c) signaling by the TCR...
  36. Schiroli G, Ferrari S, Conway A, Jacob A, Capo V, Albano L, et al. Preclinical modeling highlights the therapeutic potential of hematopoietic stem cell gene editing for correction of SCID-X1. Sci Transl Med. 2017;9: pubmed publisher
    ..We then designed a one-size-fits-all IL2RG (interleukin-2 receptor common γ-chain) gene correction strategy and, using the same reagents suitable for ..
  37. Noguchi M, Adelstein S, Cao X, Leonard W. Characterization of the human interleukin-2 receptor gamma chain gene. J Biol Chem. 1993;268:13601-8 pubmed
    ..With this study, the organization of the genes encoding all three chains (alpha, beta, and gamma) of the IL-2 receptor has been determined and promoters for each identified. ..
  38. Ravichandran K, Igras V, Shoelson S, Fesik S, Burakoff S. Evidence for a role for the phosphotyrosine-binding domain of Shc in interleukin 2 signaling. Proc Natl Acad Sci U S A. 1996;93:5275-80 pubmed
    ..Taken together, our in vivo and in vitro observations suggest that the PTB domain of Shc interacts with Y338 of the IL-2R and provide evidence for a functional role for the Shc-PTB domain in IL-2 signaling. ..
  39. Eckenberg R, Rose T, Moreau J, Weil R, Gesbert F, Dubois S, et al. The first alpha helix of interleukin (IL)-2 folds as a homotetramer, acts as an agonist of the IL-2 receptor beta chain, and induces lymphokine-activated killer cells. J Exp Med. 2000;191:529-40 pubmed
    ..Altogether, our data suggest that p1-30 has therapeutic potential...
  40. Asao H, Okuyama C, Kumaki S, Ishii N, Tsuchiya S, Foster D, et al. Cutting edge: the common gamma-chain is an indispensable subunit of the IL-21 receptor complex. J Immunol. 2001;167:1-5 pubmed
    ..The chemical cross-linking study reveals the direct binding of IL-21 to the gamma(c). These data clearly demonstrate that the gamma(c) is an indispensable subunit of the functional IL-21R complex. ..
  41. Lindholm C. IL-2 receptor signaling through the Shb adapter protein in T and NK cells. Biochem Biophys Res Commun. 2002;296:929-36 pubmed
    ..In conclusion, Shb links the IL-2 receptor to other signaling proteins and mediates the regulation of apoptosis in the presence of IL-2. ..
  42. Bani L, Pasquier V, Kryworuchko M, Salamero J, Theze J. Unstimulated human CD4 lymphocytes express a cytoplasmic immature form of the common cytokine receptor gamma-chain. J Immunol. 2001;167:344-9 pubmed
    ..Furthermore, this supports the notion that expression of the functional form of gamma(c) may require intracellular interactions with lineage- or subset-specific molecular partners. ..
  43. DiSanto J, Dautry Varsat A, Certain S, Fischer A, de Saint Basile G. Interleukin-2 (IL-2) receptor gamma chain mutations in X-linked severe combined immunodeficiency disease result in the loss of high-affinity IL-2 receptor binding. Eur J Immunol. 1994;24:475-9 pubmed
    ..Mutations in the IL-2R gamma chain-encoding gene have been found in SCIDX1, a primary immunodeficiency characterized by the absence of T cell and NK cell development...
  44. Sogo T, Kawahara M, Tsumoto K, Kumagai I, Ueda H, Nagamune T. Selective expansion of genetically modified T cells using an antibody/interleukin-2 receptor chimera. J Immunol Methods. 2008;337:16-23 pubmed publisher
    ..These results clearly demonstrate that the antibody/IL-2R chimeras could substantially mimic the wild-type IL-2R signaling, suggesting the potential application in expansion of gene-modified T cells. ..
  45. Matko J, Bodnar A, Vereb G, Bene L, Vámosi G, Szentesi G, et al. GPI-microdomains (membrane rafts) and signaling of the multi-chain interleukin-2 receptor in human lymphoma/leukemia T cell lines. Eur J Biochem. 2002;269:1199-208 pubmed
    ..g. CD48). Based on these data, the integrity of these GPI-microdomains seems critical in signal transduction through the IL-2R complex. ..
  46. Song J, Yang D, Ruan J, Zhang J, Chen Y, Xu J. Production of immunodeficient rabbits by multiplex embryo transfer and multiplex gene targeting. Sci Rep. 2017;7:12202 pubmed publisher
    ..Embryos microinjected with single sgRNA targeting FOXN1, RAG2, IL2RG or PRKDC were pooled for embryo transfer...
  47. Sharfe N, Shahar M, Roifman C. An interleukin-2 receptor gamma chain mutation with normal thymus morphology. J Clin Invest. 1997;100:3036-43 pubmed
    ..Early clinical recognition of this phenotype is critical as a delay in diagnosis may result in a fatal infection. ..
  48. Kleiman S, Pastan I, Puck J, Gottesman M. Characterization of an MDR1 retroviral bicistronic vector for correction of X-linked severe combined immunodeficiency. Gene Ther. 1998;5:671-6 pubmed
    ..The disease is caused by mutations in IL2RG, the gene encoding the interleukin-2 receptor common gamma chain (gamma c) shared by several interleukin receptors...
  49. Yurino A, Takenaka K, Yamauchi T, Nunomura T, Uehara Y, Jinnouchi F, et al. Enhanced Reconstitution of Human Erythropoiesis and Thrombopoiesis in an Immunodeficient Mouse Model with Kit(Wv) Mutations. Stem Cell Reports. 2016;7:425-438 pubmed publisher
    ..Here we show that the introduction of homozygous Kit(Wv) mutations into C57BL/6.Rag2(null)Il2rg(null) mice with NOD-Sirpa (BRGS) strongly promoted human multi-lineage reconstitution...
  50. Osinalde N, Sánchez Quiles V, Akimov V, Aloria K, Arizmendi J, Blagoev B, et al. Characterization of Receptor-Associated Protein Complex Assembly in Interleukin (IL)-2- and IL-15-Activated T-Cell Lines. J Proteome Res. 2017;16:106-121 pubmed publisher
    ....
  51. Cao X, Kozak C, Liu Y, Noguchi M, O Connell E, Leonard W. Characterization of cDNAs encoding the murine interleukin 2 receptor (IL-2R) gamma chain: chromosomal mapping and tissue specificity of IL-2R gamma chain expression. Proc Natl Acad Sci U S A. 1993;90:8464-8 pubmed
    ..Finally, we have localized the murine IL-2R gamma gene, Il2rg, to the X chromosome between Rsvp and Plp and demonstrated that a defect in IL-2R gamma is not responsible for the ..
  52. Estévez O, Ortega C, Fernandez S, Aguado R, Rumbao J, Perez Navero J, et al. A novel IL2RG mutation presenting with atypical T(-)B(+)NK+ phenotype: rapid elucidation of NK cell origin. Pediatr Blood Cancer. 2014;61:178-9 pubmed publisher
  53. Lundin K, Tuukkanen A, Jansson C, Nordström T, Lindqvist C. No soluble common cytokine receptor gamma chain (gamma(c)) in activated human lymphocyte cultures-comparison with soluble IL-2Ralpha. Immunol Lett. 2002;82:235-40 pubmed
    The presence of a soluble form of the common cytokine receptor gamma chain (gamma(c)) in cell free supernatants from unstimulated and 1-6 days PHA stimulated peripheral blood lymphocyte (PBL) cultures was analyzed using a sandwich ELISA...
  54. Gesbert F, Malardé V, Dautry Varsat A. Ubiquitination of the common cytokine receptor gammac and regulation of expression by an ubiquitination/deubiquitination machinery. Biochem Biophys Res Commun. 2005;334:474-80 pubmed
    ..Altogether, we show that gamma(c) is the target of an ubiquitination mechanism and its expression level can be regulated through the activities of a couple of ubiquitin-ligase/ubiquitin-hydrolase enzymes, namely c-Cbl/DUB-2. ..
  55. Metcalfe C, Cresswell P, Barclay A. Interleukin-2 signalling is modulated by a labile disulfide bond in the CD132 chain of its receptor. Open Biol. 2012;2:110036 pubmed publisher
    ..Recent studies have shown that a wide range of membrane proteins have labile disulfide bonds including CD132, the common gamma chain of the receptors for several cytokines including interleukin-2 and interleukin-4 (IL-2 and ..
  56. Giron Michel J, Azzi S, Khawam K, Mortier E, Caignard A, Devocelle A, et al. Interleukin-15 plays a central role in human kidney physiology and cancer through the γc signaling pathway. PLoS ONE. 2012;7:e31624 pubmed publisher
    ....
  57. Schmalstieg F, Leonard W, Noguchi M, Berg M, Rudloff H, Denney R, et al. Missense mutation in exon 7 of the common gamma chain gene causes a moderate form of X-linked combined immunodeficiency. J Clin Invest. 1995;95:1169-73 pubmed
    ..Therefore, this point mutation in the gamma c gene leads to a less severe degree of deficiency in cellular and humoral immunity than that seen in XSCID. ..
  58. Smyth C, Ginn S, Deakin C, Logan G, Alexander I. Limiting {gamma}c expression differentially affects signaling via the interleukin (IL)-7 and IL-15 receptors. Blood. 2007;110:91-8 pubmed
    ..immunodeficiency (SCID-X1) results from mutations in the IL2RG gene, which encodes the common gamma chain (gammac) of the receptors for interleukin (IL)-2, 4, 7, 9, 15, and 21...
  59. Santagostino S, Arbona R, Nashat M, White J, Monette S. Pathology of Aging in NOD scid gamma Female Mice. Vet Pathol. 2017;54:855-869 pubmed publisher
    In the past decade, NOD.Cg- Prkdcscid Il2rgtm1Wjl/SzJ (NSG, NOD scid gamma) mice have become a model of choice in several areas of biomedical research; however, comprehensive data on their spontaneous age-related ..
  60. DiSanto J, Rieux Laucat F, Dautry Varsat A, Fischer A, de Saint Basile G. Defective human interleukin 2 receptor gamma chain in an atypical X chromosome-linked severe combined immunodeficiency with peripheral T cells. Proc Natl Acad Sci U S A. 1994;91:9466-70 pubmed
    X chromosome-linked severe combined immunodeficiency disease (SCIDX1) is characterized by the absence of T-cell and natural killer cell development and results from molecular mutations of the interleukin 2 receptor (IL-2R) gamma chain...
  61. Ross J, Cheng H, Nagy Z, Frost J, Kirken R. Protein phosphatase 2A regulates interleukin-2 receptor complex formation and JAK3/STAT5 activation. J Biol Chem. 2010;285:3582-91 pubmed publisher
    ..These findings also suggest that PP2A may serve as a therapeutic target for modulating JAK3/STAT5 activation in human disease. ..
  62. Wang M, Yao L, Cheng M, Cai D, Martinek J, Pan C, et al. Humanized mice in studying efficacy and mechanisms of PD-1-targeted cancer immunotherapy. FASEB J. 2017;: pubmed publisher
    ..To this end, non-obese diabetic (NOD).Cg-PrkdcscidIL2rgtm1Wjl /Sz (null; NSG) mice were transplanted with human (h)CD34+ hematopoietic ..