Gene Symbol: IL-1beta
Description: interleukin 1 beta
Alias: IL-1, IL1-BETA, IL1F2, interleukin-1 beta, IL-1 beta, catabolin, preinterleukin 1 beta, pro-interleukin-1-beta
Species: human
Products:     IL-1beta

Top Publications

  1. Kang S, Kim J, Park N, Song Y, Park S, Kang S, et al. Interleukin-1 beta-511 polymorphism and risk of cervical cancer. J Korean Med Sci. 2007;22:110-3 pubmed
    ..In conclusion, in Korean population, IL1B -511 C/C genotypes were significantly associated with a decreased risk of cervical cancer. ..
  2. Novikov A, Cardone M, Thompson R, Shenderov K, Kirschman K, Mayer Barber K, et al. Mycobacterium tuberculosis triggers host type I IFN signaling to regulate IL-1β production in human macrophages. J Immunol. 2011;187:2540-7 pubmed publisher
    ..tuberculosis infection the induction of type I IFNs is a major mechanism used for this purpose. ..
  3. Queiroz D, Oliveira A, Saraiva I, Rocha G, Rocha A, das Graças Pimenta Sanna M, et al. Immune response and gene polymorphism profiles in Crohn's disease and ulcerative colitis. Inflamm Bowel Dis. 2009;15:353-8 pubmed publisher
    ..These results highlight the importance of different genetic profiles associated with CD and UC. ..
  4. Gomez L, Camargo J, Castiblanco J, Ruiz Narvaez E, Cadena J, Anaya J. Analysis of IL1B, TAP1, TAP2 and IKBL polymorphisms on susceptibility to tuberculosis. Tissue Antigens. 2006;67:290-6 pubmed
    ..These results indicate that a functional polymorphism in the IL1B gene influences the susceptibility to TB and suggest a role for IL-1beta in the pathogenesis of mycobacterial infection...
  5. Balding J, Livingstone W, Pittock S, Mynett Johnson L, Ahern T, Hodgson A, et al. The IL-6 G-174C polymorphism may be associated with ischaemic stroke in patients without a history of hypertension. Ir J Med Sci. 2004;173:200-3 pubmed
    ..The IL6 -174 CC genotype may be protective against stroke in those patients who have no history of hypertension. Further studies are required to verify these findings. ..
  6. Kikuchi M, Hishida A, Ishikawa K, Sagawa H, Suzuki K, Ito Y, et al. Associations between serum C-reactive protein (CRP) levels and polymorphisms of CRP, interleukin 1B, and tumor necrosis factor genes among Japanese health checkup examinees. Asian Pac J Cancer Prev. 2007;8:87-92 pubmed
    ..Since the biological mechanism is not clear, further investigations are required to confirm the association. ..
  7. Sharma R, Zucknick M, London R, Kacevska M, Liddle C, Clarke S. Systemic inflammatory response predicts prognosis in patients with advanced-stage colorectal cancer. Clin Colorectal Cancer. 2008;7:331-7 pubmed publisher
    ..05). In this patient group, inflammatory markers predict for clinical outcome. This could improve prognostication and allow for intervention strategies to reduce tumor-associated inflammation. ..
  8. Harrison P, Pointon J, Chapman K, Roddam A, Wordsworth B. Interleukin-1 promoter region polymorphism role in rheumatoid arthritis: a meta-analysis of IL-1B-511A/G variant reveals association with rheumatoid arthritis. Rheumatology (Oxford). 2008;47:1768-70 pubmed publisher
    ..No direct association between the polymorphisms studied and clinical severity characteristics were observed. Further meta-analysis revealed IL-1B (-511 A/G) to be associated with increased susceptibility to RA. ..
  9. Ahirwar D, Agrahari A, Mandhani A, Mittal R. Cytokine gene polymorphisms are associated with risk of urinary bladder cancer and recurrence after BCG immunotherapy. Biomarkers. 2009;14:213-8 pubmed publisher
    ..37) and enhanced (HR 2.24) risk of recurrence after BCG immunotherapy, respectively. The study suggests that cytokine gene variants may modulate CaB susceptibility and risk of recurrence after BCG immunotherapy. ..

More Information

Publications224 found, 100 shown here

  1. Saijo Y, Tanaka M, Miki M, Usui K, Suzuki T, Maemondo M, et al. Proinflammatory cytokine IL-1 beta promotes tumor growth of Lewis lung carcinoma by induction of angiogenic factors: in vivo analysis of tumor-stromal interaction. J Immunol. 2002;169:469-75 pubmed
    ..These results indicated that secreting IL-1beta into the tumor milieu induces several angiogenic factors from tumor and stromal cells and thus promotes tumor growth through hyperneovascularization. ..
  2. Lu P, Nakamoto Y, Nemoto Sasaki Y, Fujii C, Wang H, Hashii M, et al. Potential interaction between CCR1 and its ligand, CCL3, induced by endogenously produced interleukin-1 in human hepatomas. Am J Pathol. 2003;162:1249-58 pubmed
    ..Thus, IL-1 may enhance the local production of CCL3, which may interact with CCR1 expressed on hepatoma cells, in an autocrine and/or paracrine manner. ..
  3. Walley A, Aucan C, Kwiatkowski D, Hill A. Interleukin-1 gene cluster polymorphisms and susceptibility to clinical malaria in a Gambian case-control study. Eur J Hum Genet. 2004;12:132-8 pubmed
    ..Haplotypes constructed using the SNPHAP programme were not associated with any of the malaria phenotypes investigated. In summary, if IL1 variants are involved in malaria susceptibility in the Gambia at all, then the effects are small. ..
  4. Smith K, Bateman A, Fussell H, Howell W. Cytokine gene polymorphisms and breast cancer susceptibility and prognosis. Eur J Immunogenet. 2004;31:167-73 pubmed
    ..02, Pc = 0.36 and P = 0.05, Pc = 0.90, respectively). These results suggest that the role of cytokine promoter SNPs in both susceptibility to and prognosis in breast cancer requires further investigation in a larger study. ..
  5. Macarthur M, Sharp L, Hold G, Little J, El Omar E. The role of cytokine gene polymorphisms in colorectal cancer and their interaction with aspirin use in the northeast of Scotland. Cancer Epidemiol Biomarkers Prev. 2005;14:1613-8 pubmed
    ..These results suggest that host genetics may play a role in predicting response to chemopreventive strategies. Confirmation of these findings in other populations is required. ..
  6. Morello S, Ito K, Yamamura S, Lee K, Jazrawi E, Desouza P, et al. IL-1 beta and TNF-alpha regulation of the adenosine receptor (A2A) expression: differential requirement for NF-kappa B binding to the proximal promoter. J Immunol. 2006;177:7173-83 pubmed
  7. Hayashi F, Watanabe M, Nanba T, Inoue N, Akamizu T, Iwatani Y. Association of the -31C/T functional polymorphism in the interleukin-1beta gene with the intractability of Graves' disease and the proportion of T helper type 17 cells. Clin Exp Immunol. 2009;158:281-6 pubmed publisher
    ..In conclusion, our data indicated that the T allele of -31C/T polymorphism in the IL1B gene was involved in the intractability of GD, and this involvement may arise through the differentiation and proliferation of Th17 cells. ..
  8. Hedl M, Abraham C. Distinct roles for Nod2 protein and autocrine interleukin-1beta in muramyl dipeptide-induced mitogen-activated protein kinase activation and cytokine secretion in human macrophages. J Biol Chem. 2011;286:26440-9 pubmed publisher
    ..Our findings clarify mechanisms of IL-1? contributions to Nod2 responses and elucidate the dominant role of IL-1? in MDP-initiated MAPK and cytokine secretion. ..
  9. Jotanovic Z, Etokebe G, Mihelic R, Heiland Kårvatn M, Mulac Jericevic B, Tijanic T, et al. Hip osteoarthritis susceptibility is associated with IL1B -511(G>A) and IL1 RN (VNTR) genotypic polymorphisms in Croatian Caucasian population. J Orthop Res. 2011;29:1137-44 pubmed publisher
    ..028, OR?=?0.65, 95% CI?=?0.43-0.97). Our findings suggest that HOA in Croatian population might have a different genetic risk regarding the IL1 locus than has been reported for other Caucasian populations previously. ..
  10. Smith D, Renshaw B, Ketchem R, Kubin M, Garka K, Sims J. Four new members expand the interleukin-1 superfamily. J Biol Chem. 2000;275:1169-75 pubmed
    ..Protein structure modeling also suggests that the FIL1 genes are related to IL-1beta and IL-1ra. The novel genes form a cluster with the IL-1s on the long arm of human chromosome 2. ..
  11. Greenstein G, Hart T. A critical assessment of interleukin-1 (IL-1) genotyping when used in a genetic susceptibility test for severe chronic periodontitis. J Periodontol. 2002;73:231-47 pubmed
    ..Therefore, clinicians must cautiously interpret results obtained with the commercially available genetic susceptibility test before they alter maintenance schedules or treatment regimens of symptomatic or asymptomatic patients. ..
  12. Meisel P, Siegemund A, Grimm R, Herrmann F, John U, Schwahn C, et al. The interleukin-1 polymorphism, smoking, and the risk of periodontal disease in the population-based SHIP study. J Dent Res. 2003;82:189-93 pubmed
    ..50 (95% C.I. 1.21 to 5.13; p = 0.013). This was not the case with subjects who never smoked: OR = 1.09 (0.73-1.62; p = 0.676). These results support the hypothesis of gene-environmental interaction in periodontitis. ..
  13. Hall S, Perregaux D, Gabel C, Woodworth T, Durham L, Huizinga T, et al. Correlation of polymorphic variation in the promoter region of the interleukin-1 beta gene with secretion of interleukin-1 beta protein. Arthritis Rheum. 2004;50:1976-83 pubmed
    ..0084 and P = 0.0017). These data suggest that polymorphisms within the promoter region of the IL1B gene contribute to observed differences in LPS-induced IL-1 beta protein secretion. ..
  14. Vogel U, Christensen J, Wallin H, Friis S, Nexø B, Tjønneland A. Polymorphisms in COX-2, NSAID use and risk of basal cell carcinoma in a prospective study of Danes. Mutat Res. 2007;617:138-46 pubmed
    ..While it cannot be ruled out that the present findings are due to chance, the results indicate that high COX-2 expression may increase risk of BCC while NSAID use may be protective. ..
  15. Ter Minassian M, Zhai R, Asomaning K, Su L, Zhou W, Liu G, et al. Apoptosis gene polymorphisms, age, smoking and the risk of non-small cell lung cancer. Carcinogenesis. 2008;29:2147-52 pubmed publisher
    ..17). No interactions were observed for FAS -1377 G>A and BAT3 Ser625Pro polymorphisms. Our findings indicate that age and smoking may modify the association of the FASLG -844 and IL1B + 3954 SNPs with the risk of NSCLC. ..
  16. Chakravorty M, Datta De D, Choudhury A, Roychoudhury S. IL1B promoter polymorphism regulates the expression of gastric acid stimulating hormone gastrin. Int J Biochem Cell Biol. 2009;41:1502-10 pubmed publisher
    ..Thus, this study showed that a single base substitution at the -31 position of the IL1B promoter brought about differential expression of IL1B which differentially altered both NFkappaB activation and gastrin expression. ..
  17. Vangsted A, Klausen T, Gimsing P, Andersen N, Abildgaard N, Gregersen H, et al. A polymorphism in NFKB1 is associated with improved effect of interferon-{alpha} maintenance treatment of patients with multiple myeloma after high-dose treatment with stem cell support. Haematologica. 2009;94:1274-81 pubmed publisher
    ..A prospective study of interferon-alpha treatment in relation to NFKB1 -94ins/delATTG is highly warranted. ..
  18. Wu K, Zhou X, Zheng F, Xu X, Lin Y, Yang J. Influence of interleukin-1 beta genetic polymorphism, smoking and alcohol drinking on the risk of non-small cell lung cancer. Clin Chim Acta. 2010;411:1441-6 pubmed publisher
    ..05). The IL-1beta -31T allele was positively associated with a risk of NSCLC, and the carriers of IL-1beta -31T/T or -511C/C would have a higher risk of suffering from NSCLC if they drank alcohol or smoke heavily. ..
  19. Loughlin J, Dowling B, Mustafa Z, Chapman K. Association of the interleukin-1 gene cluster on chromosome 2q13 with knee osteoarthritis. Arthritis Rheum. 2002;46:1519-27 pubmed
    ..The IL-1 ligand cluster encodes for susceptibility to knee OA but not to hip OA, highlighting the genetic heterogeneity of this common, complex disease. ..
  20. Hwang I, Kodama T, Kikuchi S, Sakai K, Peterson L, Graham D, et al. Effect of interleukin 1 polymorphisms on gastric mucosal interleukin 1beta production in Helicobacter pylori infection. Gastroenterology. 2002;123:1793-803 pubmed
    ..IL-1 genetic polymorphisms influenced H. pylori-related gastric mucosal IL-1beta levels and were related to gastric inflammation and atrophy, factors thought to be important in gastric carcinogenesis. ..
  21. Chen C, Yang S, Liu C, Lin C, Liaw Y, Lin S, et al. Association of cytokine and DNA repair gene polymorphisms with hepatitis B-related hepatocellular carcinoma. Int J Epidemiol. 2005;34:1310-8 pubmed
    ..84; 95% CI 1.69-13.92). Genetic variations in cytokine and DNA repair genes contribute to susceptibility to HBV-related HCC. Smoking increased such genetic susceptibility. ..
  22. How A, Aung T, Chew X, Yong V, Lim M, Lee K, et al. Lack of association between interleukin-1 gene cluster polymorphisms and glaucoma in Chinese subjects. Invest Ophthalmol Vis Sci. 2007;48:2123-6 pubmed
    ..This study did not find an association between IL-1 gene cluster polymorphisms and glaucoma in this sample of Chinese subjects. ..
  23. Strandberg L, Mellstrom D, Ljunggren O, Grundberg E, Karlsson M, Holmberg A, et al. IL6 and IL1B polymorphisms are associated with fat mass in older men: the MrOS Study Sweden. Obesity (Silver Spring). 2008;16:710-3 pubmed publisher
    ..In conclusion, the IL-1 and IL-6 systems, shown to suppress mature-onset obesity in experimental animals, contain gene polymorphisms that are associated with fat, but not lean, mass in elderly men. ..
  24. Yoo E, Park S, Cho N, Kim N, Lee H, Kim D, et al. Influence of IL1B polymorphism on CpG island hypermethylation in Helicobacter pylori-infected gastric cancer. Virchows Arch. 2010;456:647-52 pubmed publisher
    ..pylori infection and IL1B-511T/T allele. ..
  25. Michaud D, Daugherty S, Berndt S, Platz E, Yeager M, Crawford E, et al. Genetic polymorphisms of interleukin-1B (IL-1B), IL-6, IL-8, and IL-10 and risk of prostate cancer. Cancer Res. 2006;66:4525-30 pubmed
    ..At least seven common polymorphisms in genes of inflammatory cytokines IL-1B, IL-6, IL-8, and IL-10 do not seem to play a role in the risk of prostate cancer. ..
  26. Jiang Y, Wang M, Huang K, Zhang Z, Shao N, Zhang Y, et al. Oxidized low-density lipoprotein induces secretion of interleukin-1? by macrophages via reactive oxygen species-dependent NLRP3 inflammasome activation. Biochem Biophys Res Commun. 2012;425:121-6 pubmed publisher
    ..Therefore, our results suggest that the role of ox-LDL in atherosclerosis-related inflammation may involve the activation of the NLRP3 inflammasome. ..
  27. Matsuo K, Hamajima N, Ikehara Y, Suzuki T, Nakamura T, Matsuura A, et al. Smoking and polymorphisms of fucosyltransferase gene Le affect success of H. pylori eradication with lansoprazole, amoxicillin, and clarithromycin. Epidemiol Infect. 2003;130:227-33 pubmed
    ..Although further clarification is necessary, our study indicated that smoking cessation and Le gene polymorphisms may affect the success rate of HP eradication. ..
  28. Rad R, Prinz C, Neu B, Neuhofer M, Zeitner M, Voland P, et al. Synergistic effect of Helicobacter pylori virulence factors and interleukin-1 polymorphisms for the development of severe histological changes in the gastric mucosa. J Infect Dis. 2003;188:272-81 pubmed
    ..8-32.1) for severe granulocytic infiltration, 6.0 (95% CI, 2.4-15.5) for IM, and 2.4 (95% CI, 0.93-6.2) for AG. Combined bacterial/host genotyping thus may provide a clinical tool to identify patients at high risk of developing cancer. ..
  29. Erbek S, Yurtcu E, Erbek S, Atac F, Sahin F, Cakmak O. Proinflammatory cytokine single nucleotide polymorphisms in nasal polyposis. Arch Otolaryngol Head Neck Surg. 2007;133:705-9 pubmed
    ..05). The IL1A (4845 GT and 4845 TT), IL1B (-511 CC), and TNFA (-238 AA and -308 GA) genotypes were associated with susceptibility to NP in our study population. ..
  30. Gattorno M, Tassi S, Carta S, Delfino L, Ferlito F, Pelagatti M, et al. Pattern of interleukin-1beta secretion in response to lipopolysaccharide and ATP before and after interleukin-1 blockade in patients with CIAS1 mutations. Arthritis Rheum. 2007;56:3138-48 pubmed
    ..These findings may have implications for other chronic inflammatory conditions characterized by increased IL-1beta. ..
  31. Zhu Y, Xu Y, Wei Y, Liang W, Liao M, Zhang L. Association of IL-1B gene polymorphisms with nasopharyngeal carcinoma in a Chinese population. Clin Oncol (R Coll Radiol). 2008;20:207-11 pubmed publisher
  32. Coker A, Arman A, Soylu O, Tezel T, Yildirim A. Lack of association between IL-1 and IL-6 gene polymorphisms and myocardial infarction in Turkish population. Int J Immunogenet. 2011;38:201-8 pubmed publisher
    ..Thus, IL-1 and IL-6 single nucleotide polymorphisms may not be a risk factor for susceptibility to MI in Turkish population. ..
  33. Deng J, Qin P, Li X, Du Y. Association between interleukin-1? C (3953/4)T polymorphism and chronic periodontitis: evidence from a meta-analysis. Hum Immunol. 2013;74:371-8 pubmed publisher
    ..This meta-analysis indicates that there is strong evidence for association between IL-1? C(3953/4)T polymorphism and CP. ..
  34. Lee J, Heur M. Interleukin-1? enhances cell migration through AP-1 and NF-?B pathway-dependent FGF2 expression in human corneal endothelial cells. Biol Cell. 2013;105:175-89 pubmed publisher
    ..The results show that binding of IL-1? to its receptor in human CEC leads to parallel activation of AP-1 and NF-?B pathways, leading, in turn, to FGF2 expression and enhanced cell migration. ..
  35. Debets R, Timans J, Homey B, Zurawski S, Sana T, Lo S, et al. Two novel IL-1 family members, IL-1 delta and IL-1 epsilon, function as an antagonist and agonist of NF-kappa B activation through the orphan IL-1 receptor-related protein 2. J Immunol. 2001;167:1440-6 pubmed
  36. Aksentijevich I, Nowak M, Mallah M, Chae J, Watford W, Hofmann S, et al. De novo CIAS1 mutations, cytokine activation, and evidence for genetic heterogeneity in patients with neonatal-onset multisystem inflammatory disease (NOMID): a new member of the expanding family of pyrin-associated autoinflammatory diseases. Arthritis Rheum. 2002;46:3340-8 pubmed
    ..IL-1 regulation by CIAS1 suggests that IL-1 receptor blockade may constitute a rational approach to the treatment of NOMID/CINCA syndrome. ..
  37. Machado J, Figueiredo C, Canedo P, Pharoah P, Carvalho R, Nabais S, et al. A proinflammatory genetic profile increases the risk for chronic atrophic gastritis and gastric carcinoma. Gastroenterology. 2003;125:364-71 pubmed
    ..These findings show that a proinflammatory polymorphism in the TNF-alpha gene is associated with increased risk for GC, and that it is possible to define a specific genetic profile associated with highest risk for CAG and GC. ..
  38. Argaw A, Zhang Y, Snyder B, Zhao M, Kopp N, Lee S, et al. IL-1beta regulates blood-brain barrier permeability via reactivation of the hypoxia-angiogenesis program. J Immunol. 2006;177:5574-84 pubmed
    ..These results suggest that IL-1beta contributes to BBB permeability in MS via reactivation of the HIF-VEGF axis. This pathway may represent a potential therapeutic target to restrict lesion formation. ..
  39. Kusuhara K, Yamamoto K, Okada K, Mizuno Y, Hara T. Association of IL12RB1 polymorphisms with susceptibility to and severity of tuberculosis in Japanese: a gene-based association analysis of 21 candidate genes. Int J Immunogenet. 2007;34:35-44 pubmed
    ..These data suggested that genetic variants of IL12RB1, at least in part, confer genetic susceptibility to TB, and are associated with the progression of the disease, in Japanese. ..
  40. Yang H, Cohen P, Rousseau S. IL-1beta-stimulated activation of ERK1/2 and p38alpha MAPK mediates the transcriptional up-regulation of IL-6, IL-8 and GRO-alpha in HeLa cells. Cell Signal. 2008;20:375-80 pubmed
  41. Goverdhan S, Ennis S, Hannan S, Madhusudhana K, Cree A, Luff A, et al. Interleukin-8 promoter polymorphism -251A/T is a risk factor for age-related macular degeneration. Br J Ophthalmol. 2008;92:537-40 pubmed publisher
    ..043, OR = 1.23, 95% CI = 1.0 to 1.50). The pro-inflammatory homozygous IL8 -251AA genotype is an important risk factor for AMD. This may have implications for future therapy with biological agents that could target this cytokine. ..
  42. Fan Z, Bau B, Yang H, Aigner T. IL-1beta induction of IL-6 and LIF in normal articular human chondrocytes involves the ERK, p38 and NFkappaB signaling pathways. Cytokine. 2004;28:17-24 pubmed
    ..However, the ERK-pathway appeared to be particularly important and might be, therefore, of particular potential if one intends to block induction of these molecules by IL-1 in arthritic joint disease. ..
  43. Vangsted A, Klausen T, Ruminski W, Gimsing P, Andersen N, Gang A, et al. The polymorphism IL-1beta T-31C is associated with a longer overall survival in patients with multiple myeloma undergoing auto-SCT. Bone Marrow Transplant. 2009;43:539-45 pubmed publisher
    ..37-fold (CI=1.05-1.80) increased risk of MM as compared with population-based controls (P=0.02). Our results indicate that IL-1beta is involved in the pathogenesis of MM. ..
  44. Maury C, Liljestrom M, Laiho K, Tiitinen S, Kaarela K, Hurme M. Anaemia of chronic disease in AA amyloidosis is associated with allele 2 of the interleukin-1beta-511 promoter gene and raised levels of interleukin-1beta and interleukin-18. J Intern Med. 2004;256:145-52 pubmed
    ..In AA amyloidosis the raised cytokine levels may generate a vicious cycle leading to accelerated amyloidogenesis, suppression of erythropoiesis and aggravation of the underlying inflammatory disorder. ..
  45. Sicinschi L, Lopez Carrillo L, Camargo M, Correa P, Sierra R, Henry R, et al. Gastric cancer risk in a Mexican population: role of Helicobacter pylori CagA positive infection and polymorphisms in interleukin-1 and -10 genes. Int J Cancer. 2006;118:649-57 pubmed
    ..pylori. Our results support the identification of the IL1B-31 promoter polymorphism as a useful marker for risk of intestinal type gastric cancer in persons with CagA positive H. pylori infections. ..
  46. Moriconi F, Raddatz D, Ho N, Yeruva S, Dudas J, Ramadori G. Quantitative gene expression of cytokines in peripheral blood leukocytes stimulated in vitro: modulation by the anti-tumor nerosis factor-alpha antibody infliximab and comparison with the mucosal cytokine expression in patients with ulcerative coliti. Transl Res. 2007;150:223-32 pubmed
    ..The in vitro model of PHA-stimulated PBLs may mimic inflammation processes observed in vivo. INFL may reduce inflammation in vivo through inhibition of both monocyte and T-cell activation. ..
  47. Liu Y, Li S, Zhang G, Nie G, Meng Z, Mao D, et al. Genetic variants in IL1A and IL1B contribute to the susceptibility to 2009 pandemic H1N1 influenza A virus. BMC Immunol. 2013;14:37 pubmed publisher
    ..This study provides a new insight into pathogenesis of A(H1N1)pdm09, suggesting that genetic variants of IL-1A and IL-1B may exert a substantial impact on the susceptibility of A(H1N1)pdm09 virus infection. ..
  48. McCulley M, Day I, Holmes C. Association between interleukin 1-beta promoter (-511) polymorphism and depressive symptoms in Alzheimer's disease. Am J Med Genet B Neuropsychiatr Genet. 2004;124B:50-3 pubmed
    ..However, an allelic association was found between the T variant and the symptoms of depression in AD subjects. Genotypic analysis showed that heterozygotes were three times more likely to develop depressive symptoms than CC homozygotes. ..
  49. Chang Y, Jang J, Kim N, Lee J, Lee H, Jung W, et al. Interleukin-1B (IL-1B) polymorphisms and gastric mucosal levels of IL-1beta cytokine in Korean patients with gastric cancer. Int J Cancer. 2005;114:465-71 pubmed
    ..Thus, the combined effects of H. pylori infection and IL-1B-31T/IL-1B-511C polymorphisms with enhanced mucosal IL-1beta production contributed to the development of intestinal-type GC in this Korean population. ..
  50. Motsinger Reif A, Antas P, Oki N, Levy S, Holland S, Sterling T. Polymorphisms in IL-1beta, vitamin D receptor Fok1, and Toll-like receptor 2 are associated with extrapulmonary tuberculosis. BMC Med Genet. 2010;11:37 pubmed publisher
    ..Additional studies of the underlying mechanism of these genetic variants are warranted. ..
  51. Lee S, Ihm C, Sohn S, Lee T, Kim M, Koh G, et al. Polymorphisms in interleukin-1 beta and Interleukin-1 receptor antagonist genes are associated with kidney failure in Korean patients with type 2 diabetes mellitus. Am J Nephrol. 2004;24:410-4 pubmed
    ..90, 95% CI 1.34-11.40). IL1B2 and IL1RN*2 genotypes of the IL-1 cluster genes are associated with diabetic nephropathy in Korean patients with type 2 DM. ..
  52. Wang W, Ni K, Zhou G. Association of IL1B polymorphisms with gastric cancer in a Chinese population. Clin Biochem. 2007;40:218-25 pubmed
    ..86, P=0.03) between patients and controls. ALM-ASA is a potential method for multiplex SNP typing with a low consumption of genomic DNA. SNPs 0794C>T, 1274C>T, and 2143T>C are associated with gastric cancer. ..
  53. Misener V, Gomez L, Wigg K, Luca P, King N, Kiss E, et al. Cytokine Genes TNF, IL1A, IL1B, IL6, IL1RN and IL10, and childhood-onset mood disorders. Neuropsychobiology. 2008;58:71-80 pubmed publisher
    ..The present study does not support the involvement of the TNF, IL1A, IL1B, IL6, IL1RN and IL10 variants as major genetic risk factors contributing to early-onset mood disorders. ..
  54. Meulenbelt I, Bos S, Kloppenburg M, Lakenberg N, Houwing Duistermaat J, Watt I, et al. Interleukin-1 gene cluster variants with innate cytokine production profiles and osteoarthritis in subjects from the Genetics, Osteoarthritis and Progression Study. Arthritis Rheum. 2010;62:1119-26 pubmed publisher
    ..The data further indicate that, among subjects with OA affecting the highest number of joints, the innate immune system may be activated, thereby obscuring possible underlying mechanisms. ..
  55. Tassi S, Carta S, Delfino L, Caorsi R, Martini A, Gattorno M, et al. Altered redox state of monocytes from cryopyrin-associated periodic syndromes causes accelerated IL-1beta secretion. Proc Natl Acad Sci U S A. 2010;107:9789-94 pubmed publisher
  56. Alanbay I, Coksuer H, Ercan C, Ustun Y, Pala G, Karasahin K, et al. Chitotriosidase, interleukin-1 beta and tumor necrosis factor alpha levels in mild preeclampsia. Arch Gynecol Obstet. 2012;285:1505-11 pubmed publisher
    Chitotriosidase (ChT) is an activated macrophage marker. Tumor necrosis factor alpha (TNF-?) and interleukin 1 beta (IL-1?) are mainly produced macrophages...
  57. Taguchi A, Ohmiya N, Shirai K, Mabuchi N, Itoh A, Hirooka Y, et al. Interleukin-8 promoter polymorphism increases the risk of atrophic gastritis and gastric cancer in Japan. Cancer Epidemiol Biomarkers Prev. 2005;14:2487-93 pubmed
    ..In conclusion, we showed that the IL-8 -251 T > A polymorphism is associated with higher expression of IL-8 protein, more severe neutrophil infiltration, and increased risk of atrophic gastritis and gastric cancer. ..
  58. White C, Dimitriadis E, Sharkey A, Stoikos C, Salamonsen L. Interleukin 1 beta is induced by interleukin 11 during decidualization of human endometrial stromal cells, but is not released in a bioactive form. J Reprod Immunol. 2007;73:28-38 pubmed
    ..This study aimed to examine the effect of IL11 on interleukin 1 beta (IL1B) mRNA and protein expression during in vitro decidualization of ESC...
  59. Shirts B, Wood J, Yolken R, Nimgaonkar V. Association study of IL10, IL1beta, and IL1RN and schizophrenia using tag SNPs from a comprehensive database: suggestive association with rs16944 at IL1beta. Schizophr Res. 2006;88:235-44 pubmed
    ..0013, or=1.24, 95% ci 1.09, 1.41). ..
  60. Camargo M, Mera R, Correa P, Peek R, Fontham E, Goodman K, et al. Interleukin-1beta and interleukin-1 receptor antagonist gene polymorphisms and gastric cancer: a meta-analysis. Cancer Epidemiol Biomarkers Prev. 2006;15:1674-87 pubmed
    ..The meta-analyses suggest that the conflicting results among studies may be explained by variation in allele frequencies among the ethnic groups and variation in tumor types, as well as by the methodologic quality of the studies. ..
  61. Chang Y, Wu M, Shun C, Lin M, Chang M, Lin J. Association of polymorphisms of interleukin-1 beta gene and Helicobacter pylori infection with the risk of gastric ulcer. Hepatogastroenterology. 2002;49:1474-6 pubmed
  62. zur Hausen A, Crusius J, Murillo L, Alizadeh B, Morre S, Meijer C, et al. IL-1B promoter polymorphism and Epstein-Barr virus in Dutch patients with gastric carcinoma. Int J Cancer. 2003;107:866-7 pubmed
  63. Wang P, Xia H, Zhang J, Dai L, Xu X, Wang K. Association of interleukin-1 gene polymorphisms with gastric cancer: a meta-analysis. Int J Cancer. 2007;120:552-62 pubmed
    ..30, 95% CI: 1.09-1.54). In conclusion, IL-1B-511 and IL-1RN genetic polymorphisms are associated with an increased risk of developing gastric cancer. ..
  64. Li C, Xia H, Xie W, Hu Z, Ye M, Li J, et al. Association between interleukin-1 gene polymorphisms and Helicobacter pylori infection in gastric carcinogenesis in a Chinese population. J Gastroenterol Hepatol. 2007;22:234-9 pubmed
    ..pylori infection in non-cardiac gastric cancer in a Chinese population. The IL-1B-511 gene polymorphism appears to play an important role in gastric carcinogenesis in Chinese patients with H. pylori infection. ..
  65. Cimaz R, Cazalis M, Reynaud C, Gerloni V, Zulian F, Biggioggero M, et al. IL1 and TNF gene polymorphisms in patients with juvenile idiopathic arthritis treated with TNF inhibitors. Ann Rheum Dis. 2007;66:900-4 pubmed
    ..The TNF and IL1 gene polymorphism studied did not seem to be associated with response to anti-TNF treatment. ..
  66. Javor J, Bucova M, Ferencik S, Grosse Wilde H, Buc M. Single nucleotide polymorphisms of cytokine genes in the healthy Slovak population. Int J Immunogenet. 2007;34:273-80 pubmed
    ..However, several differences were found between the Slovak and four populations from Southern Europe. The obtained data represent a basis for further studies on association of cytokine gene polymorphisms with some diseases. ..
  67. Liu P, Schenk M, Walker V, Dempsey P, Kanchanapoomi M, Wheelwright M, et al. Convergence of IL-1beta and VDR activation pathways in human TLR2/1-induced antimicrobial responses. PLoS ONE. 2009;4:e5810 pubmed publisher
    ..Therefore, these data identify a novel mechanism of host defense requiring the induction of IL-1beta in synergy with vitamin D activation, for the TLR-induced antimicrobial pathway against an intracellular pathogen. ..
  68. Solovieva S, Leino Arjas P, Saarela J, Luoma K, Raininko R, Riihimaki H. Possible association of interleukin 1 gene locus polymorphisms with low back pain. Pain. 2004;109:8-19 pubmed
    ..The results suggest a possible contribution of the IL-1 gene locus polymorphisms to the pathogenesis of LBP. The possibility of chance findings cannot be excluded due to the small sample size. ..
  69. Zee R, Hennessey H, Michaud S, Ridker P. Genetic variants within the interleukin-1 gene cluster, and risk of incident myocardial infarction, and ischemic stroke: a nested case-control approach. Atherosclerosis. 2008;201:124-9 pubmed publisher
    ..In contrast to prior retrospective studies, our prospective data suggest that the IL-1 cluster gene variation is not associated with risk of athero-thrombotic disorders. ..
  70. Kaarthikeyan G, Jayakumar N, Padmalatha O, Sheeja V, Sankari M, Anandan B. Analysis of the association between interleukin-1beta (+3954) gene polymorphism and chronic periodontitis in a sample of the south Indian population. Indian J Dent Res. 2009;20:37-40 pubmed
    ..In conclusion, our data suggested that there was no significant association between IL-1beta (+3954) gene polymorphism and chronic periodontitis in the south Indian population. ..
  71. Soria G, Ofri Shahak M, Haas I, Yaal Hahoshen N, Leider Trejo L, Leibovich Rivkin T, et al. Inflammatory mediators in breast cancer: coordinated expression of TNF? & IL-1? with CCL2 & CCL5 and effects on epithelial-to-mesenchymal transition. BMC Cancer. 2011;11:130 pubmed publisher
    ..Further in vitro and in vivo studies are needed for determination of the joint powers of the four factors in breast cancer, as well as analyses of their combined targeting in breast cancer. ..
  72. McCarron S, Edwards S, Evans P, Gibbs R, Dearnaley D, Dowe A, et al. Influence of cytokine gene polymorphisms on the development of prostate cancer. Cancer Res. 2002;62:3369-72 pubmed
    ..05). These results suggest that single nucleotide polymorphisms associated with differential production of IL-8, IL-10, and VEGF are risk factors for PC, possibly acting via their influence on angiogenesis. ..
  73. Zumkeller N, Brenner H, Chang Claude J, Hoffmeister M, Nieters A, Rothenbacher D. Helicobacter pylori infection, interleukin-1 gene polymorphisms and the risk of colorectal cancer: evidence from a case-control study in Germany. Eur J Cancer. 2007;43:1283-9 pubmed
    ..Additionally, a pro-inflammatory genotype did not increase the colorectal cancer risk associated with H. pylori infection. H. pylori positive subjects carrying the pro-inflammatory genotypes even had a lower risk. ..
  74. Kim S, Mok J, Kim H, Joo C. Association of -31T>C and -511 C>T polymorphisms in the interleukin 1 beta (IL1B) promoter in Korean keratoconus patients. Mol Vis. 2008;14:2109-16 pubmed
    ..the genetic association between unrelated Korean keratoconus patients and interleukin 1 alpha (IL1A), interleukin 1 beta (IL1B), and IL1 receptor antagonist (IL1RN) gene polymorphisms...
  75. Nishimura M, Kawakami H, Komure O, Maruyama H, Morino H, Izumi Y, et al. Contribution of the interleukin-1beta gene polymorphism in multiple system atrophy. Mov Disord. 2002;17:808-11 pubmed
    ..The frequency of IL-1A-889*2, a high secretor of IL-1alpha, was also decreased in MSA patients. Our findings suggest that abnormal cytokine expression may be implicated in the pathogenesis of MSA. ..
  76. Chen R, Chen W, Chang C, Tsai C, Tsai F. Interleukin-1-beta gene, but not the interleukin-1 receptor antagonist gene, is associated with Graves' disease. J Clin Lab Anal. 2005;19:133-8 pubmed
    ..It is worthwhile to study the cytokine genes further because of the association between cytokines and Graves' disease. ..
  77. Lai J, Zhou D, Xia S, Shang Y, Zhu J, Pan J, et al. Association of interleukin-1 gene cluster polymorphisms with ischemic stroke in a Chinese population. Neurol India. 2006;54:366-9 pubmed
    ..No significant differences were found in the IL-1beta -511 genotype and the allele distribution between the two groups. Our results implicated that IL-1 gene polymorphism might be associated with the susceptibility to ischemic stroke. ..
  78. Palmqvist P, Lundberg P, Lundgren I, Hänström L, Lerner U. IL-1beta and TNF-alpha regulate IL-6-type cytokines in gingival fibroblasts. J Dent Res. 2008;87:558-63 pubmed
  79. Levy H, Murphy A, Zou F, Gerard C, Klanderman B, Schuemann B, et al. IL1B polymorphisms modulate cystic fibrosis lung disease. Pediatr Pulmonol. 2009;44:580-93 pubmed publisher
    ..06 for both SNPs) in both the analysis of lung disease severity in the UNC/CWRU cohort and the family-based analysis of affection status. Our findings suggest that IL1beta is a clinically relevant modulator of CF lung disease. ..
  80. Mikami T, Meguro A, Teshigawara T, Takeuchi M, Uemoto R, Kawagoe T, et al. Interleukin 1 beta promoter polymorphism is associated with keratoconus in a Japanese population. Mol Vis. 2013;19:845-51 pubmed
    ..0×10(-5), pc=1.6×10(-4)). Our results replicate associations reported recently in a Korean population. Thus, IL1B may play an important role in the development of keratoconus through genetic polymorphisms. ..
  81. Li C, Wang C. Current evidences on IL1B polymorphisms and lung cancer susceptibility: a meta-analysis. Tumour Biol. 2013;34:3477-82 pubmed publisher
    ..However, larger number of samples and studies with homogeneous lung cancer patients are needed to confirm these findings. ..
  82. Allan S, Parker L, Collins B, Davies R, Luheshi G, Rothwell N. Cortical cell death induced by IL-1 is mediated via actions in the hypothalamus of the rat. Proc Natl Acad Sci U S A. 2000;97:5580-5 pubmed
  83. Stern A, de Carvalho M, Buck G, Adler R, Rao T, Disler D, et al. Association of erosive hand osteoarthritis with a single nucleotide polymorphism on the gene encoding interleukin-1 beta. Osteoarthritis Cartilage. 2003;11:394-402 pubmed
    ..Statistical evidence shows association between erosive hand OA and a genomic region containing the IL1B 5810 SNP in a US Caucasoid population. This supports a potential role for IL-1 in the pathogenesis of a severe phenotype of hand OA. ..
  84. Hailey K, Li S, Andersen M, Roy M, Woods V, Jennings P. Pro-interleukin (IL)-1beta shares a core region of stability as compared with mature IL-1beta while maintaining a distinctly different configurational landscape: a comparative hydrogen/deuterium exchange mass spectrometry study. J Biol Chem. 2009;284:26137-48 pubmed publisher
    ..The presence of the self-inhibiting precursor region provides yet another layer of regulation in the life cycle of this important cytokine. ..
  85. Dinarello C, Donath M, Mandrup Poulsen T. Role of IL-1beta in type 2 diabetes. Curr Opin Endocrinol Diabetes Obes. 2010;17:314-21 pubmed publisher
    ..Monotherapy or add-on therapy targeting IL-1beta in type 2 diabetes holds promise for long-term benefits in glycemic control and possibly reducing cardiovascular events. ..
  86. He B, Zhang Y, Pan Y, Xu Y, Gu L, Chen L, et al. Interleukin 1 beta (IL1B) promoter polymorphism and cancer risk: evidence from 47 published studies. Mutagenesis. 2011;26:637-42 pubmed publisher
    ..116). Although some modest bias could not be eliminated, this meta-analysis suggests that the IL1B -31C allele is a low-penetrance protective factor for the development of cancer, in particular for that associated with infection. ..
  87. Lea W, Lee Y. The associations between interleukin-1 polymorphisms and susceptibility to ankylosing spondylitis: a meta-analysis. Joint Bone Spine. 2012;79:370-4 pubmed publisher
    ..3 and IL-1A+889 polymorphisms are associated with the development of AS in Europeans but not in Asians. ..
  88. Roy D, Sarkar S, Felty Q. Levels of IL-1 beta control stimulatory/inhibitory growth of cancer cells. Front Biosci. 2006;11:889-98 pubmed
  89. Tadic A, Rujescu D, Muller M, Kohnen R, Stassen H, Szegedi A, et al. Association analysis between variants of the interleukin-1beta and the interleukin-1 receptor antagonist gene and antidepressant treatment response in major depression. Neuropsychiatr Dis Treat. 2008;4:269-76 pubmed
    ..An independent replication of our finding is needed. If replicated, the IL-1beta C-511T promoter polymorphism could be considered useful for prospective confirmatory pharmacogenetic trials in patients with major depression. ..
  90. Corleto V, Pagnini C, Margagnoni G, Guagnozzi D, Torre M, Martorelli M, et al. IL-1beta-511 and IL-1RN*2 polymorphisms in inflammatory bowel disease: An Italian population study and meta-analysis of European studies. Dig Liver Dis. 2010;42:179-84 pubmed publisher
    ..The IL-1beta-511 mutation can be associated with complex disease behaviour in Italian Crohn's disease patients. The IL-1RN*2 mutation may play a role in Northern European people with inflammatory bowel disease. ..