Gene Symbol: IL-1beta
Description: interleukin 1 beta
Alias: IL-1, IL1-BETA, IL1F2, interleukin-1 beta, IL-1 beta, catabolin, preinterleukin 1 beta, pro-interleukin-1-beta
Species: human
Products:     IL-1beta

Top Publications

  1. Novikov A, Cardone M, Thompson R, Shenderov K, Kirschman K, Mayer Barber K, et al. Mycobacterium tuberculosis triggers host type I IFN signaling to regulate IL-1β production in human macrophages. J Immunol. 2011;187:2540-7 pubmed publisher
    ..tuberculosis infection the induction of type I IFNs is a major mechanism used for this purpose. ..
  2. Queiroz D, Oliveira A, Saraiva I, Rocha G, Rocha A, das Graças Pimenta Sanna M, et al. Immune response and gene polymorphism profiles in Crohn's disease and ulcerative colitis. Inflamm Bowel Dis. 2009;15:353-8 pubmed publisher
    ..These results highlight the importance of different genetic profiles associated with CD and UC. ..
  3. Gomez L, Camargo J, Castiblanco J, Ruiz Narvaez E, Cadena J, Anaya J. Analysis of IL1B, TAP1, TAP2 and IKBL polymorphisms on susceptibility to tuberculosis. Tissue Antigens. 2006;67:290-6 pubmed
    ..These results indicate that a functional polymorphism in the IL1B gene influences the susceptibility to TB and suggest a role for IL-1beta in the pathogenesis of mycobacterial infection...
  4. Gruica B, Wang H, Lang N, Buser D. Impact of IL-1 genotype and smoking status on the prognosis of osseointegrated implants. Clin Oral Implants Res. 2004;15:393-400 pubmed
    ..These findings have led to the conclusion that there is a synergistic effect between a positive IL-1 genotype and smoking that puts dental implants at a significantly higher risk of developing biologic complications during function. ..
  5. Snoussi K, Strosberg A, Bouaouina N, Ben Ahmed S, Chouchane L. Genetic variation in pro-inflammatory cytokines (interleukin-1beta, interleukin-1alpha and interleukin-6) associated with the aggressive forms, survival, and relapse prediction of breast carcinoma. Eur Cytokine Netw. 2005;16:253-60 pubmed
    ..The polymorphisms in the promoter region of the IL-6 gene may represent a marker for the increased risk of breast carcinoma. Genetic variations in IL-1alpha, IL-1beta and IL-6 may predict the clinical outcome of breast carcinoma. ..
  6. Ennas M, Moore P, Zucca M, Angelucci E, Cabras M, Melis M, et al. Interleukin-1B (IL1B) and interleukin-6 (IL6) gene polymorphisms are associated with risk of chronic lymphocytic leukaemia. Hematol Oncol. 2008;26:98-103 pubmed publisher
  7. De Jongh C, Khrenova L, Kezic S, Rustemeyer T, Verberk M, John S. Polymorphisms in the interleukin-1 gene influence the stratum corneum interleukin-1 alpha concentration in uninvolved skin of patients with chronic irritant contact dermatitis. Contact Dermatitis. 2008;58:263-8 pubmed publisher
    ..We have shown a clear effect of IL1 genotype on protein expression in the SC. This altered expression may be responsible for the interindividual differences in the inflammatory response of the skin. ..
  8. Vishnoi M, Pandey S, Choudhuri G, Mittal B. IL-1 gene polymorphisms and genetic susceptibility of gallbladder cancer in a north Indian population. Cancer Genet Cytogenet. 2008;186:63-8 pubmed publisher
    ..061; OR = 3.04; 95%CI = 0.95-9.70). Individuals with 1/C and 2/C haplotypes of IL-1RN VNTR and -511IL-1B C --> T polymorphisms were more susceptible to develop GBC with gallstones compared to healthy controls in north India. ..
  9. Cordeiro C, Moreira P, Costa G, Dutra W, Campos W, Orefice F, et al. Interleukin-1 gene polymorphisms and toxoplasmic retinochoroiditis. Mol Vis. 2008;14:1845-9 pubmed
    ..This study suggests that the genotypes related with a high production of IL-1a may be associated with the recurrence of TR. ..

More Information

Publications297 found, 100 shown here

  1. Bartchewsky W, Martini M, Masiero M, Squassoni A, Alvarez M, Ladeira M, et al. Effect of Helicobacter pylori infection on IL-8, IL-1beta and COX-2 expression in patients with chronic gastritis and gastric cancer. Scand J Gastroenterol. 2009;44:153-61 pubmed publisher
  2. Chen F, Cheng W. [Correlation of IL-1beta-511 and IL-1RN VNTR gene polymorphism to coronary heart disease: a meta-analysis]. Nan Fang Yi Ke Da Xue Xue Bao. 2010;30:1635-8 pubmed
    ..01 and the 95% CI was 0.78-1.17 (Z=0.08, P=0.93). The gene polymorphism of IL-1beta-511 or IL-1RN VNTR has no correlation to the susceptibility of CHD, but is associated with in the disease development and clinical phenotype. ..
  3. Machado J, Pharoah P, Sousa S, Carvalho R, Oliveira C, Figueiredo C, et al. Interleukin 1B and interleukin 1RN polymorphisms are associated with increased risk of gastric carcinoma. Gastroenterology. 2001;121:823-9 pubmed
    ..Furthermore, we found evidence pointing to the existence of a synergistic interaction between the IL-1B and IL-1RN polymorphisms. ..
  4. Deng L, Wang C, Spencer E, Yang L, Braun A, You J, et al. Activation of the IkappaB kinase complex by TRAF6 requires a dimeric ubiquitin-conjugating enzyme complex and a unique polyubiquitin chain. Cell. 2000;103:351-61 pubmed
    ..These results unveil a new regulatory function for ubiquitin, in which IKK is activated through the assembly of K63-linked polyubiquitin chains. ..
  5. Meisel P, Schwahn C, Gesch D, Bernhardt O, John U, Kocher T. Dose-effect relation of smoking and the interleukin-1 gene polymorphism in periodontal disease. J Periodontol. 2004;75:236-42 pubmed
    ..Smokers bearing the genotype-positive IL-1 allele combination have an increased risk of periodontitis. The IL-1 genotype has no influence in non-smokers. ..
  6. Atsuta Y, Kawase H, Hamajima N, Nishio K, Niwa Y, Tanaka D, et al. Use of duplex PCR-CTPP methods for CYP2E1RsaI/IL-2 T-330G and IL-1B C-31T/TNF-A T-1031C polymorphisms. Mol Diagn. 2005;9:89-94 pubmed
    ..Both duplex PCR-CTPP methods may be useful tools for studies on the association between these polymorphisms and disease risk. ..
  7. Kamangar F, Abnet C, Hutchinson A, Newschaffer C, Helzlsouer K, Shugart Y, et al. Polymorphisms in inflammation-related genes and risk of gastric cancer (Finland). Cancer Causes Control. 2006;17:117-25 pubmed
    ..Our results do not support the hypothesis that polymorphisms in genes involved in the inflammatory response confer differences in gastric cancer risk among different individuals. ..
  8. Abazis Stamboulieh D, Oikonomou P, Papadoulis N, Panayiotidis P, Vrakidou E, Tsezou A. Association of interleukin-1A, interleukin-1B and interleukin-1 receptor antagonist gene polymorphisms with multiple myeloma. Leuk Lymphoma. 2007;48:2196-203 pubmed
    ..Moreover, genotypes IL1B -511 CC, IL1B +3954 CC, IL-1RN Mspa1 +11100 CC and the combination of IL1B +3954 CC with IL1B -511 CC or IL-1RN Mspa1 +11100 CC exerted a protective effect in individuals possessing them. ..
  9. Tassi S, Carta S, Vené R, Delfino L, Ciriolo M, Rubartelli A. Pathogen-induced interleukin-1beta processing and secretion is regulated by a biphasic redox response. J Immunol. 2009;183:1456-62 pubmed publisher
    ..Thus, PAMP-induced ROS trigger an antioxidant response involving intracellular redox enzymes and release of cysteine, ultimately required for IL-1beta processing and secretion. ..
  10. Kato S, Onda M, Yamada S, Matsuda N, Tokunaga A, Matsukura N. Association of the interleukin-1 beta genetic polymorphism and gastric cancer risk in Japanese. J Gastroenterol. 2001;36:696-9 pubmed
    ..However, in view of the results for the IM or CAG without H. pylori group, the presence of the C allele may also indicate a risk of mucosal atrophy of the stomach in the Japanese population. ..
  11. van der Paardt M, Crusius J, Garcia Gonzalez M, Baudoin P, Kostense P, Alizadeh B, et al. Interleukin-1beta and interleukin-1 receptor antagonist gene polymorphisms in ankylosing spondylitis. Rheumatology (Oxford). 2002;41:1419-23 pubmed
    ..Further studies are necessary to determine the biological significance of these findings in relation to susceptibility or severity of the disease. ..
  12. Lin H, Tsai S, Tsai F, Chen W, Tsai J, Hsu C. Association of interleukin 1beta and receptor antagonist gene polymorphisms with primary open-angle glaucoma. Ophthalmologica. 2003;217:358-64 pubmed
    ..Furthermore, we have concluded that the other 2 polymorphisms (IL-1 promoter 511 and IL-1Ra) are not helpful in predicting Chinese POAG. ..
  13. Reiniger N, Lee M, Coleman F, Ray C, Golan D, Pier G. Resistance to Pseudomonas aeruginosa chronic lung infection requires cystic fibrosis transmembrane conductance regulator-modulated interleukin-1 (IL-1) release and signaling through the IL-1 receptor. Infect Immun. 2007;75:1598-608 pubmed
    ..Overall, rapid IL-1 release and signaling through IL-1R represent key steps in the innate immune response to P. aeruginosa infection, and this process is deficient in cells lacking functional CFTR. ..
  14. Eskan M, Benakanakere M, Rose B, Zhang P, Zhao J, Stathopoulou P, et al. Interleukin-1beta modulates proinflammatory cytokine production in human epithelial cells. Infect Immun. 2008;76:2080-9 pubmed publisher
    ..gingivalis, and this process may be an inflammatory enhancement mechanism adopted by epithelial cells. ..
  15. Zhu Y, Xu Y, Zhou B, Liang W, Wang Y, Gao L, et al. [Association of interleukin-1B gene polymorphisms with coronary heart disease]. Sichuan Da Xue Xue Bao Yi Xue Ban. 2009;40:73-6 pubmed
    ..12, 95% CI: 1.45-3.09, P < 0.01). Genotypes and allele frequencies at IL-1B + 3953 locus in CHD cases did not differ from the controls. IL-1B -31T/C polymorphism may contribute to the risk of developing CHD in Chengdu Han population. ..
  16. Hsieh M, Chong I, Hwang J, Lee C, Ho C, Yu M, et al. Lack of associations between several polymorphisms in cytokine genes and the risk of chronic obstructive pulmonary diseases in Taiwan. Kaohsiung J Med Sci. 2008;24:126-37 pubmed publisher
    ..Despite this, smoking is still an important risk factor for developing COPD. ..
  17. Santos J, Ladeira M, Pedrazzoli J, Ribeiro M. Relationship of IL-1 and TNF-? polymorphisms with Helicobacter pylori in gastric diseases in a Brazilian population. Braz J Med Biol Res. 2012;45:811-7 pubmed
    ..Similar results were found for TNF-? -308 gene polymorphisms. Our results indicate that the IL-1? -511 C/C and C/T gene polymorphisms are associated with chronic gastritis and GC development in H. pylori-infected individuals. ..
  18. Momiyama Y, Hirano R, Taniguchi H, Nakamura H, Ohsuzu F. Effects of interleukin-1 gene polymorphisms on the development of coronary artery disease associated with Chlamydia pneumoniae infection. J Am Coll Cardiol. 2001;38:712-7 pubmed
    ..8). The variants were associated with MI only in patients with CP seropositivity. The IL-1 gene polymorphisms were found to play a role in the development of CAD, especially MI, in patients with CP infection. ..
  19. Wang Y, Kato N, Hoshida Y, Yoshida H, Taniguchi H, Goto T, et al. Interleukin-1beta gene polymorphisms associated with hepatocellular carcinoma in hepatitis C virus infection. Hepatology. 2003;37:65-71 pubmed
    ..73 (T/T vs. C/C), 4.12, 4.03, 3.89, and 3.27, respectively. In conclusion, the IL-1beta-31 genotype T/T or the IL-1beta-511/-31 haplotype C-T is associated with the presence of HCC in Japanese patients with chronic HCV infection. ..
  20. Starzynska T, Ferenc K, Wex T, Kahne T, Lubinski J, Lawniczak M, et al. The association between the interleukin-1 polymorphisms and gastric cancer risk depends on the family history of gastric carcinoma in the study population. Am J Gastroenterol. 2006;101:248-54 pubmed
    ..This phenomenon may be in part responsible for differences in results of interleukin-1 studies performed on populations with low and high gastric cancer prevalence. ..
  21. Mandey S, Kuijk L, Frenkel J, Waterham H. A role for geranylgeranylation in interleukin-1beta secretion. Arthritis Rheum. 2006;54:3690-5 pubmed
    ..The goal of our study was to determine whether a temporary shortage of certain isoprenoid end products and/or the accumulation of mevalonic acid is the cause of interleukin-1beta (IL-1beta) secretion in MKD...
  22. Ouma C, Davenport G, Awandare G, Keller C, Were T, Otieno M, et al. Polymorphic variability in the interleukin (IL)-1beta promoter conditions susceptibility to severe malarial anemia and functional changes in IL-1beta production. J Infect Dis. 2008;198:1219-26 pubmed publisher
    ..The results presented demonstrate that variation in IL-1beta promoter conditions susceptibility to SMA and functional changes in circulating IL-1beta levels. ..
  23. Okamoto M, Liu W, Luo Y, Tanaka A, Cai X, Norris D, et al. Constitutively active inflammasome in human melanoma cells mediating autoinflammation via caspase-1 processing and secretion of interleukin-1beta. J Biol Chem. 2010;285:6477-88 pubmed publisher
  24. Sasayama D, Hori H, Iijima Y, Teraishi T, Hattori K, Ota M, et al. Modulation of cortisol responses to the DEX/CRH test by polymorphisms of the interleukin-1beta gene in healthy adults. Behav Brain Funct. 2011;7:23 pubmed publisher
    ..Confirmation of our findings in futures studies may add new insight into the communication between the immune system and the HPA axis. ..
  25. Cigrovski Berković M, Catela Ivkovic T, Marout J, Zjacic Rotkvic V, Kapitanovic S. Interleukin 1? gene single-nucleotide polymorphisms and susceptibility to pancreatic neuroendocrine tumors. DNA Cell Biol. 2012;31:531-6 pubmed publisher
    ..We believe that our findings will contribute to understanding of the etiology and possible novel prognostic markers for pNETs when future studies investigating the serum and tumor tissue IL1? levels are done. ..
  26. Smith A, Keen L, Billingham M, Perry M, Elson C, Kirwan J, et al. Extended haplotypes and linkage disequilibrium in the IL1R1-IL1A-IL1B-IL1RN gene cluster: association with knee osteoarthritis. Genes Immun. 2004;5:451-60 pubmed
    ..0000008). These results may help to explain the genome-wide scan linkage data and functional observations concerning association between IL-1 and OA. ..
  27. Lu W, Pan K, Zhang L, Lin D, Miao X, You W. Genetic polymorphisms of interleukin (IL)-1B, IL-1RN, IL-8, IL-10 and tumor necrosis factor {alpha} and risk of gastric cancer in a Chinese population. Carcinogenesis. 2005;26:631-6 pubmed
    ..These findings suggest that genetic polymorphisms in IL-8, IL-10 and TNFalpha may play important roles in developing gastric cancer in the Chinese population. ..
  28. Sakuma K, Uozaki H, Chong J, Hironaka M, Sudo M, Ushiku T, et al. Cancer risk to the gastric corpus in Japanese, its correlation with interleukin-1beta gene polymorphism (+3953*T) and Epstein-Barr virus infection. Int J Cancer. 2005;115:93-7 pubmed
    ..On the other hand, the risk of EBV-associated GC, which occurs predominantly in the corpus, is not influenced by this pro-inflammatory polymorphism. ..
  29. Perri F, Piepoli A, Bonvicini C, Gentile A, Quitadamo M, Di Candia M, et al. Cytokine gene polymorphisms in gastric cancer patients from two Italian areas at high and low cancer prevalence. Cytokine. 2005;30:293-302 pubmed
    ..An epistatic interrelationship between IL-1beta -511 and IL-1RN confers protection against gastric cancer in low-risk Italian population. ..
  30. Strandberg L, Lorentzon M, Hellqvist A, Nilsson S, Wallenius V, Ohlsson C, et al. Interleukin-1 system gene polymorphisms are associated with fat mass in young men. J Clin Endocrinol Metab. 2006;91:2749-54 pubmed
    ..The IL-1beta-31 polymorphism did not correlate with the fat measurements. The IL-1 system, recently shown to affect fat mass in experimental animals, contains gene polymorphisms that are associated with fat mass in young men. ..
  31. Gunter M, Canzian F, Landi S, Chanock S, Sinha R, Rothman N. Inflammation-related gene polymorphisms and colorectal adenoma. Cancer Epidemiol Biomarkers Prev. 2006;15:1126-31 pubmed
    ..7; 95% CI, 0.3-1.5; P(interaction) = 0.01). These exploratory data provide evidence that polymorphic variation in genes that regulate inflammation could alter risk for colorectal adenoma. ..
  32. Martínez Carrillo D, Garza Gonzalez E, Betancourt Linares R, Mónico Manzano T, Antúnez Rivera C, Román Román A, et al. Association of IL1B -511C/-31T haplotype and Helicobacter pylori vacA genotypes with gastric ulcer and chronic gastritis. BMC Gastroenterol. 2010;10:126 pubmed publisher
    ..In the southern Mexican population, the IL-1B -511C and -31T alleles and the -511C/-31T and -511T/-31T haplotypes are associated with increased risk of chronic gastritis and gastric ulcer. ..
  33. Kaijzel E, van Dongen H, Bakker A, Breedveld F, Huizinga T, Verweij C. Relationship of polymorphisms of the Interleukin-1 gene cluster to occurrence and severity of rheumatoid arthritis. Tissue Antigens. 2002;59:122-6 pubmed
    ..These data indicate that the IL-1RN + 2017 polymorphism is associated with susceptibility to RA. ..
  34. Kim Y, Kwon E, Park D, Song S, Yoon S, Baek S. Interleukin-1beta induces MUC2 and MUC5AC synthesis through cyclooxygenase-2 in NCI-H292 cells. Mol Pharmacol. 2002;62:1112-8 pubmed
    ..These results indicate that in human pulmonary epithelial cells, IL-1beta activates ERK or p38 to induce COX-2 production, which in turn induces MUC2 and MUC5AC production. ..
  35. Gyan B, Goka B, Cvetkovic J, Perlmann H, Lefvert A, Akanmori B, et al. Polymorphisms in interleukin-1beta and interleukin-1 receptor antagonist genes and malaria in Ghanaian children. Scand J Immunol. 2002;56:619-22 pubmed
    ..01). The mean parasitaemia in an age-matched asymptomatic group did not reveal such associations. These data suggest that IL-1beta exon 5 allele 2 may play a possible role in the clinical outcome of uncomplicated malaria. ..
  36. Spranger J, Kroke A, Mohlig M, Hoffmann K, Bergmann M, Ristow M, et al. Inflammatory cytokines and the risk to develop type 2 diabetes: results of the prospective population-based European Prospective Investigation into Cancer and Nutrition (EPIC)-Potsdam Study. Diabetes. 2003;52:812-7 pubmed
    ..These data strongly support the hypothesis that a subclinical inflammatory reaction has a role in the pathogenesis of type 2 diabetes. ..
  37. Hirankarn N, Kimkong I, Kummee P, Tangkijvanich P, Poovorawan Y. Interleukin-1beta gene polymorphism associated with hepatocellular carcinoma in hepatitis B virus infection. World J Gastroenterol. 2006;12:776-9 pubmed
    ..IL-1B-511C allele, which may be associated with high IL-1B production in the liver, is a genetic marker for the development of HCC in chronic hepatitis B patients in Thai population. ..
  38. Nilkaeo A, Bhuvanath S. Interleukin-1 modulation of human placental trophoblast proliferation. Mediators Inflamm. 2006;2006:79359 pubmed
    ..These findings demonstrated that IL-1 regulates human trophoblast growth by induction of cell cycle delay and cell death. ..
  39. ten Kate M, Hofland L, van Koetsveld P, Jeekel J, van Eijck C. Pro-inflammatory cytokines affect pancreatic carcinoma cell. Endothelial cell interactions. JOP. 2006;7:454-64 pubmed
  40. Achyut B, Srivastava A, Bhattacharya S, Mittal B. Genetic association of interleukin-1beta (-511C/T) and interleukin-1 receptor antagonist (86 bp repeat) polymorphisms with Type 2 diabetes mellitus in North Indians. Clin Chim Acta. 2007;377:163-9 pubmed
    ..The IL-1beta (-511C/T) and IL-1RN (VNTR) polymorphisms are significantly associated with increased risk of T2DM as well as associated complications in North Indians. ..
  41. Eickholz P, Kaltschmitt J, Berbig J, Reitmeir P, Pretzl B. Tooth loss after active periodontal therapy. 1: patient-related factors for risk, prognosis, and quality of outcome. J Clin Periodontol. 2008;35:165-74 pubmed publisher
    ..The following risk factors for tooth loss were identified: ineffective oral hygiene, irregular SPT, IL-1 polymorphism, initial diagnosis, smoking, age and sex. ..
  42. Rogus J, Beck J, Offenbacher S, Huttner K, Iacoviello L, Latella M, et al. IL1B gene promoter haplotype pairs predict clinical levels of interleukin-1beta and C-reactive protein. Hum Genet. 2008;123:387-98 pubmed publisher
    ..These findings may apply to other inducible genes and could provide a logical framework for exploring disease risk related to genetic variability in pathogenic mediators. ..
  43. Piccini A, Carta S, Tassi S, Lasiglié D, Fossati G, Rubartelli A. ATP is released by monocytes stimulated with pathogen-sensing receptor ligands and induces IL-1beta and IL-18 secretion in an autocrine way. Proc Natl Acad Sci U S A. 2008;105:8067-72 pubmed publisher
    ..Thus, stimuli acting on different pathogen-sensing receptors converge on a common pathway where ATP externalization is the first step in the cascade of events leading to inflammasome activation and IL-1beta and IL-18 secretion. ..
  44. Arman A, Soylu O, Yildirim A, Furman A, Ercelen N, Aydogan H, et al. Interleukin-1 receptor antagonist gene VNTR polymorphism is associated with coronary artery disease. Arq Bras Cardiol. 2008;91:293-8 pubmed
    ..No association was found in either allele frequency or genotype distribution of IL1RN and IL1B polymorphisms between CAD and the control groups. However; IL1RN 2/2 genotype may be a risk factor for SVD in the Turkish population. ..
  45. Rechcinski T, Grebowska A, Kurpesa M, Sztybrych M, Peruga J, Trzos E, et al. Interleukin-1b and interleukin-1 receptor inhibitor gene cluster polymorphisms in patients with coronary artery disease after percutaneous angioplasty or coronary artery bypass grafting. Kardiol Pol. 2009;67:601-10 pubmed
    ..e. -31TT and -511CC, are at a higher risk of developing coronary artery disease requiring surgical treatment or two-stage percutaneous angioplasty. ..
  46. Rios D, Cerqueira C, Bonfim Silva R, Araújo L, Pereira J, Gadelha S, et al. Interleukin-1 beta and interleukin-6 gene polymorphism associations with angiographically assessed coronary artery disease in Brazilians. Cytokine. 2010;50:292-6 pubmed publisher
    ..This report shows that the IL-1B-511C>T and IL-6-174G>C polymorphisms were associated with CAD risk in African-Brazilians and no association was detected among Caucasian-Brazilians. ..
  47. Schauer I, Zhang J, Xing Z, Guo X, Mercado Uribe I, Sood A, et al. Interleukin-1? promotes ovarian tumorigenesis through a p53/NF-?B-mediated inflammatory response in stromal fibroblasts. Neoplasia. 2013;15:409-20 pubmed
    ..These findings implicate CAFs as an important target for blocking inflammation in the tumor microenvironment and reducing tumor growth. ..
  48. El Omar E, Carrington M, Chow W, McColl K, Bream J, Young H, et al. Interleukin-1 polymorphisms associated with increased risk of gastric cancer. Nature. 2000;404:398-402 pubmed
    ..Host genetic factors that affect interleukin-1-beta may determine why some individuals infected with H. pylori develop gastric cancer while others do not. ..
  49. Uno M, Hamajima N, Ito L, Oba S, Marie S, Shinjo S, et al. Helicobacter pylori seropositivity and IL-1B C-31T polymorphism among Japanese Brazilians. Int J Mol Med. 2002;10:321-6 pubmed
    ..8%, and had no association with the HP seropositivity. The observed association between HP+ and IL-1B -31TT indicated that the genetic trait also influences the susceptibility to HP for Japanese in Brazil. ..
  50. Figueiredo C, Machado J, Pharoah P, Seruca R, Sousa S, Carvalho R, et al. Helicobacter pylori and interleukin 1 genotyping: an opportunity to identify high-risk individuals for gastric carcinoma. J Natl Cancer Inst. 2002;94:1680-7 pubmed
    ..Polymorphisms in the human interleukin 1 beta (IL-1B) gene (IL-1B-511*C or IL-1B-511*T) and in the IL-1 receptor antagonist gene (IL-1RN intron 2 variable ..
  51. Take S, Mizuno M, Ishiki K, Nagahara Y, Yoshida T, Inaba T, et al. Interleukin-1beta genetic polymorphism influences the effect of cytochrome P 2C19 genotype on the cure rate of 1-week triple therapy for Helicobacter pylori infection. Am J Gastroenterol. 2003;98:2403-8 pubmed
    ..IL-1beta genetic polymorphism, although not an independent factor in treatment outcome, influences the impact of the CYP2C19 genotype on the cure rate of 1-wk triple therapy for H. pylori infection. ..
  52. Lin M, Storer B, Martin P, Tseng L, Gooley T, Chen P, et al. Relation of an interleukin-10 promoter polymorphism to graft-versus-host disease and survival after hematopoietic-cell transplantation. N Engl J Med. 2003;349:2201-10 pubmed
    ..Among recipients of hematopoietic cells from an HLA-identical sibling, the IL10 -592A allele is a marker of a favorable outcome after transplantation. ..
  53. Watanabe Y, Nunokawa A, Kaneko N, Muratake T, Koizumi M, Someya T. Lack of association between the interleukin-1 gene complex and schizophrenia in a Japanese population. Psychiatry Clin Neurosci. 2007;61:364-9 pubmed
    ..The results of the present study suggest that the IL1 gene complex does not play a major role in conferring susceptibility to schizophrenia in the Japanese population. ..
  54. Hänninen K, Katila H, Saarela M, Rontu R, Mattila K, Fan M, et al. Interleukin-1 beta gene polymorphism and its interactions with neuregulin-1 gene polymorphism are associated with schizophrenia. Eur Arch Psychiatry Clin Neurosci. 2008;258:10-5 pubmed
    ..46; p = 0.032). Our results suggest that there is an interaction between the IL-1B and NRG-1 genes in schizophrenia. In addition, the IL-1B-511 polymorphism seems to be associated with the age at onset of schizophrenia. ..
  55. Sierra R, Une C, Ramirez V, Alpizar Alpizar W, Gonzalez M, Ramirez J, et al. Relation of atrophic gastritis with Helicobacter pylori-CagA(+) and interleukin-1 gene polymorphisms. World J Gastroenterol. 2008;14:6481-7 pubmed
    ..The pro-inflammatory cytokine polymorphisms IL-1B + 3945 and IL-1RN are not associated with the atrophic lesions of this dyspeptic population. ..
  56. Ni H, Shi D, Dai J, Qin J, Xu Y, Zhu L, et al. Genetic polymorphisms of interleukin-1beta (-511C/T) and interleukin-1 receptor antagonist (86-bpVNTR) in susceptibility to knee osteoarthritis in a Chinese Han population. Rheumatol Int. 2009;29:1301-5 pubmed publisher
    ..The genetic polymorphisms of interleukin-1beta and interleukin-1 receptor antagonist are not risk factors for OA etiology in Han Chinese. ..
  57. Gehmert S, Velapatino B, Herrera P, Balqui J, Santivañez L, Cok J, et al. Interleukin-1 beta single-nucleotide polymorphism's C allele is associated with elevated risk of gastric cancer in Helicobacter pylori-infected Peruvians. Am J Trop Med Hyg. 2009;81:804-10 pubmed publisher
    ..Given the high prevalence of H. pylori and recurrence rate after treatment, IL-1B-511 single-nucleotide polymorphism analysis may identify those individuals who would benefit most from robust H. pylori eradication efforts in Peru. ..
  58. Teles R, Gursky L, Faveri M, Rosa E, Teles F, Feres M, et al. Relationships between subgingival microbiota and GCF biomarkers in generalized aggressive periodontitis. J Clin Periodontol. 2010;37:313-23 pubmed publisher
    ..Aggressive periodontitis subjects were characterized by a higher IL-1beta/IL-10 ratio than periodontally healthy subjects, suggesting an imbalance between pro- and anti-inflammatory cytokines in aggressive periodontitis. ..
  59. Wang P, Zhu F, Konstantopoulos K. The antagonistic actions of endogenous interleukin-1? and 15-deoxy-?12,14-prostaglandin J2 regulate the temporal synthesis of matrix metalloproteinase-9 in sheared chondrocytes. J Biol Chem. 2012;287:31877-93 pubmed publisher
    ..Reconstructing the signaling network that regulates shear-mediated MMP-9 expression in human chondrocytes may provide insights for developing strategies to treat arthritic disorders...
  60. Coeshott C, Ohnemus C, Pilyavskaya A, Ross S, Wieczorek M, Kroona H, et al. Converting enzyme-independent release of tumor necrosis factor alpha and IL-1beta from a stimulated human monocytic cell line in the presence of activated neutrophils or purified proteinase 3. Proc Natl Acad Sci U S A. 1999;96:6261-6 pubmed
    ..Use of purified enzymes confirmed this conclusion. These results indicate that there may be alternative pathways for the production of these two proinflammatory cytokines, particularly in the context of local inflammatory processes. ..
  61. Arend W. The balance between IL-1 and IL-1Ra in disease. Cytokine Growth Factor Rev. 2002;13:323-40 pubmed
    ..Treatment of RA with daily subcutaneous injections of recombinant IL-1Ra protein has been shown to be efficacious. Gene therapy approaches with IL-1Ra are being evaluated for the treatment of RA and other human diseases. ..
  62. Hernandez Guerrero C, Monzon Bordonaba F, Jimenez Zamudio L, Ahued Ahued R, Arechavaleta Velasco F, Strauss J, et al. In-vitro secretion of proinflammatory cytokines by human amniochorion carrying hyper-responsive gene polymorphisms of tumour necrosis factor-alpha and interleukin-1beta. Mol Hum Reprod. 2003;9:625-9 pubmed
  63. Zeng Z, Hu P, Hu S, Pang R, Chen M, Ng M, et al. Association of interleukin 1B gene polymorphism and gastric cancers in high and low prevalence regions in China. Gut. 2003;52:1684-9 pubmed
    ..1, 95% CI 3.8-76.4). IL-1B -511T/T genotypes are associated with gastric cancer in China. The effect of IL-1B polymorphism is less obvious in areas of high prevalence for gastric cancer. ..
  64. Seno H, Satoh K, Tsuji S, Shiratsuchi T, Harada Y, Hamajima N, et al. Novel interleukin-4 and interleukin-1 receptor antagonist gene variations associated with non-cardia gastric cancer in Japan: comprehensive analysis of 207 polymorphisms of 11 cytokine genes. J Gastroenterol Hepatol. 2007;22:729-37 pubmed
    ..pylori infection. Distinct host cytokine responses in the gastric mucosa might have a role in H. pylori-induced carcinogenesis. ..
  65. Liu N, Li X, Liu C, Zhao Y, Cui B, Ning G. The association of interleukin-1alpha and interleukin-1beta polymorphisms with the risk of Graves' disease in a case-control study and meta-analysis. Hum Immunol. 2010;71:397-401 pubmed publisher
    ..70, p = 0.002) and GO (OR = 0.65, p = 0.02). The results confirmed that the rs1800587 (IL-alpha, T-889 C) and rs16944 (IL-1beta, A-511 G) polymorphisms may confer susceptibility to GD and GO in Asian population. ..
  66. He B, Pan Y, Xu Y, Zhu C, Qu L, Wang S. Polymorphisms in interleukin-1B (IL-1B) and interleukin 1 receptor antagonist (IL-1RN) genes associate with gastric cancer risk in the Chinese population. Dig Dis Sci. 2011;56:2017-23 pubmed publisher
    ..The data from the current study demonstrated that the genotype CC or CT of IL-1B-31, TT or CT of IL-1B-511, and 2L of IL-1RN increased risk of gastric cancer in this Chinese population and the risk was further enhanced by H. pylori. ..
  67. Stegger J, Schmidt E, Tjønneland A, Kopp T, Sørensen T, Vogel U, et al. Single nucleotide polymorphisms in IL1B and the risk of acute coronary syndrome: a Danish case-cohort study. PLoS ONE. 2012;7:e36829 pubmed publisher
    ..Genetic variation in the promoter region of IL1B may not be associated with incident ACS in men or women above the age of 50 years. ..
  68. Balding J, Livingstone W, Pittock S, Mynett Johnson L, Ahern T, Hodgson A, et al. The IL-6 G-174C polymorphism may be associated with ischaemic stroke in patients without a history of hypertension. Ir J Med Sci. 2004;173:200-3 pubmed
    ..The IL6 -174 CC genotype may be protective against stroke in those patients who have no history of hypertension. Further studies are required to verify these findings. ..
  69. Kikuchi M, Hishida A, Ishikawa K, Sagawa H, Suzuki K, Ito Y, et al. Associations between serum C-reactive protein (CRP) levels and polymorphisms of CRP, interleukin 1B, and tumor necrosis factor genes among Japanese health checkup examinees. Asian Pac J Cancer Prev. 2007;8:87-92 pubmed
    ..Since the biological mechanism is not clear, further investigations are required to confirm the association. ..
  70. Sharma R, Zucknick M, London R, Kacevska M, Liddle C, Clarke S. Systemic inflammatory response predicts prognosis in patients with advanced-stage colorectal cancer. Clin Colorectal Cancer. 2008;7:331-7 pubmed publisher
    ..05). In this patient group, inflammatory markers predict for clinical outcome. This could improve prognostication and allow for intervention strategies to reduce tumor-associated inflammation. ..
  71. Harrison P, Pointon J, Chapman K, Roddam A, Wordsworth B. Interleukin-1 promoter region polymorphism role in rheumatoid arthritis: a meta-analysis of IL-1B-511A/G variant reveals association with rheumatoid arthritis. Rheumatology (Oxford). 2008;47:1768-70 pubmed publisher
    ..No direct association between the polymorphisms studied and clinical severity characteristics were observed. Further meta-analysis revealed IL-1B (-511 A/G) to be associated with increased susceptibility to RA. ..
  72. Ahirwar D, Agrahari A, Mandhani A, Mittal R. Cytokine gene polymorphisms are associated with risk of urinary bladder cancer and recurrence after BCG immunotherapy. Biomarkers. 2009;14:213-8 pubmed publisher
    ..37) and enhanced (HR 2.24) risk of recurrence after BCG immunotherapy, respectively. The study suggests that cytokine gene variants may modulate CaB susceptibility and risk of recurrence after BCG immunotherapy. ..
  73. Saijo Y, Tanaka M, Miki M, Usui K, Suzuki T, Maemondo M, et al. Proinflammatory cytokine IL-1 beta promotes tumor growth of Lewis lung carcinoma by induction of angiogenic factors: in vivo analysis of tumor-stromal interaction. J Immunol. 2002;169:469-75 pubmed
    ..These results indicated that secreting IL-1beta into the tumor milieu induces several angiogenic factors from tumor and stromal cells and thus promotes tumor growth through hyperneovascularization. ..
  74. Lu P, Nakamoto Y, Nemoto Sasaki Y, Fujii C, Wang H, Hashii M, et al. Potential interaction between CCR1 and its ligand, CCL3, induced by endogenously produced interleukin-1 in human hepatomas. Am J Pathol. 2003;162:1249-58 pubmed
    ..Thus, IL-1 may enhance the local production of CCL3, which may interact with CCR1 expressed on hepatoma cells, in an autocrine and/or paracrine manner. ..
  75. Walley A, Aucan C, Kwiatkowski D, Hill A. Interleukin-1 gene cluster polymorphisms and susceptibility to clinical malaria in a Gambian case-control study. Eur J Hum Genet. 2004;12:132-8 pubmed
    ..Haplotypes constructed using the SNPHAP programme were not associated with any of the malaria phenotypes investigated. In summary, if IL1 variants are involved in malaria susceptibility in the Gambia at all, then the effects are small. ..
  76. Grimm C, Berger I, Tomovski C, Zeillinger R, Concin N, Leodolter S, et al. A polymorphism of the interleukin-1 receptor antagonist plays a prominent role within the interleukin-1 gene cluster in vulvar carcinogenesis. Gynecol Oncol. 2004;92:936-40 pubmed
    ..Reflecting its biological role, the common IL1RN intron 2 polymorphism seems to play a prominent role within the IL-1 gene cluster with respect to vulvar carcinogenesis. ..
  77. Smith K, Bateman A, Fussell H, Howell W. Cytokine gene polymorphisms and breast cancer susceptibility and prognosis. Eur J Immunogenet. 2004;31:167-73 pubmed
    ..02, Pc = 0.36 and P = 0.05, Pc = 0.90, respectively). These results suggest that the role of cytokine promoter SNPs in both susceptibility to and prognosis in breast cancer requires further investigation in a larger study. ..
  78. Macarthur M, Sharp L, Hold G, Little J, El Omar E. The role of cytokine gene polymorphisms in colorectal cancer and their interaction with aspirin use in the northeast of Scotland. Cancer Epidemiol Biomarkers Prev. 2005;14:1613-8 pubmed
    ..These results suggest that host genetics may play a role in predicting response to chemopreventive strategies. Confirmation of these findings in other populations is required. ..
  79. Morello S, Ito K, Yamamura S, Lee K, Jazrawi E, Desouza P, et al. IL-1 beta and TNF-alpha regulation of the adenosine receptor (A2A) expression: differential requirement for NF-kappa B binding to the proximal promoter. J Immunol. 2006;177:7173-83 pubmed
  80. Hayashi F, Watanabe M, Nanba T, Inoue N, Akamizu T, Iwatani Y. Association of the -31C/T functional polymorphism in the interleukin-1beta gene with the intractability of Graves' disease and the proportion of T helper type 17 cells. Clin Exp Immunol. 2009;158:281-6 pubmed publisher
    ..In conclusion, our data indicated that the T allele of -31C/T polymorphism in the IL1B gene was involved in the intractability of GD, and this involvement may arise through the differentiation and proliferation of Th17 cells. ..
  81. Hedl M, Abraham C. Distinct roles for Nod2 protein and autocrine interleukin-1beta in muramyl dipeptide-induced mitogen-activated protein kinase activation and cytokine secretion in human macrophages. J Biol Chem. 2011;286:26440-9 pubmed publisher
    ..Our findings clarify mechanisms of IL-1? contributions to Nod2 responses and elucidate the dominant role of IL-1? in MDP-initiated MAPK and cytokine secretion. ..
  82. Jotanovic Z, Etokebe G, Mihelic R, Heiland Kårvatn M, Mulac Jericevic B, Tijanic T, et al. Hip osteoarthritis susceptibility is associated with IL1B -511(G>A) and IL1 RN (VNTR) genotypic polymorphisms in Croatian Caucasian population. J Orthop Res. 2011;29:1137-44 pubmed publisher
    ..028, OR?=?0.65, 95% CI?=?0.43-0.97). Our findings suggest that HOA in Croatian population might have a different genetic risk regarding the IL1 locus than has been reported for other Caucasian populations previously. ..
  83. Smith D, Renshaw B, Ketchem R, Kubin M, Garka K, Sims J. Four new members expand the interleukin-1 superfamily. J Biol Chem. 2000;275:1169-75 pubmed
    ..Protein structure modeling also suggests that the FIL1 genes are related to IL-1beta and IL-1ra. The novel genes form a cluster with the IL-1s on the long arm of human chromosome 2. ..
  84. Greenstein G, Hart T. A critical assessment of interleukin-1 (IL-1) genotyping when used in a genetic susceptibility test for severe chronic periodontitis. J Periodontol. 2002;73:231-47 pubmed
    ..Therefore, clinicians must cautiously interpret results obtained with the commercially available genetic susceptibility test before they alter maintenance schedules or treatment regimens of symptomatic or asymptomatic patients. ..
  85. Meisel P, Siegemund A, Grimm R, Herrmann F, John U, Schwahn C, et al. The interleukin-1 polymorphism, smoking, and the risk of periodontal disease in the population-based SHIP study. J Dent Res. 2003;82:189-93 pubmed
    ..50 (95% C.I. 1.21 to 5.13; p = 0.013). This was not the case with subjects who never smoked: OR = 1.09 (0.73-1.62; p = 0.676). These results support the hypothesis of gene-environmental interaction in periodontitis. ..
  86. Hall S, Perregaux D, Gabel C, Woodworth T, Durham L, Huizinga T, et al. Correlation of polymorphic variation in the promoter region of the interleukin-1 beta gene with secretion of interleukin-1 beta protein. Arthritis Rheum. 2004;50:1976-83 pubmed
    ..0084 and P = 0.0017). These data suggest that polymorphisms within the promoter region of the IL1B gene contribute to observed differences in LPS-induced IL-1 beta protein secretion. ..
  87. Vogel U, Christensen J, Wallin H, Friis S, Nexø B, Tjønneland A. Polymorphisms in COX-2, NSAID use and risk of basal cell carcinoma in a prospective study of Danes. Mutat Res. 2007;617:138-46 pubmed
    ..While it cannot be ruled out that the present findings are due to chance, the results indicate that high COX-2 expression may increase risk of BCC while NSAID use may be protective. ..
  88. Ter Minassian M, Zhai R, Asomaning K, Su L, Zhou W, Liu G, et al. Apoptosis gene polymorphisms, age, smoking and the risk of non-small cell lung cancer. Carcinogenesis. 2008;29:2147-52 pubmed publisher
    ..17). No interactions were observed for FAS -1377 G>A and BAT3 Ser625Pro polymorphisms. Our findings indicate that age and smoking may modify the association of the FASLG -844 and IL1B + 3954 SNPs with the risk of NSCLC. ..
  89. Chakravorty M, Datta De D, Choudhury A, Roychoudhury S. IL1B promoter polymorphism regulates the expression of gastric acid stimulating hormone gastrin. Int J Biochem Cell Biol. 2009;41:1502-10 pubmed publisher
    ..Thus, this study showed that a single base substitution at the -31 position of the IL1B promoter brought about differential expression of IL1B which differentially altered both NFkappaB activation and gastrin expression. ..
  90. Vangsted A, Klausen T, Gimsing P, Andersen N, Abildgaard N, Gregersen H, et al. A polymorphism in NFKB1 is associated with improved effect of interferon-{alpha} maintenance treatment of patients with multiple myeloma after high-dose treatment with stem cell support. Haematologica. 2009;94:1274-81 pubmed publisher
    ..A prospective study of interferon-alpha treatment in relation to NFKB1 -94ins/delATTG is highly warranted. ..
  91. Wu K, Zhou X, Zheng F, Xu X, Lin Y, Yang J. Influence of interleukin-1 beta genetic polymorphism, smoking and alcohol drinking on the risk of non-small cell lung cancer. Clin Chim Acta. 2010;411:1441-6 pubmed publisher
    ..05). The IL-1beta -31T allele was positively associated with a risk of NSCLC, and the carriers of IL-1beta -31T/T or -511C/C would have a higher risk of suffering from NSCLC if they drank alcohol or smoke heavily. ..