IFN-gamma

Summary

Gene Symbol: IFN-gamma
Description: interferon gamma
Alias: IFG, IFI, interferon gamma, IFN-gamma, immune interferon
Species: human
Products:     IFN-gamma

Top Publications

  1. Sekimata M, Pérez Melgosa M, Miller S, Weinmann A, Sabo P, Sandstrom R, et al. CCCTC-binding factor and the transcription factor T-bet orchestrate T helper 1 cell-specific structure and function at the interferon-gamma locus. Immunity. 2009;31:551-64 pubmed publisher
    ..The results demonstrate that cooperation between architectural (CTCF) and transcriptional enhancing (T-bet) factors and the elements to which they bind is required for proper Th1 cell-specific expression of Ifng. ..
  2. Collier S, Collins P, Williams C, Boothby M, Aune T. Cutting edge: influence of Tmevpg1, a long intergenic noncoding RNA, on the expression of Ifng by Th1 cells. J Immunol. 2012;189:2084-8 pubmed publisher
    ..Our results suggest that TMEVPG1 belongs to the general class of lincRNAs that positively regulate gene transcription...
  3. Dong J, Chang H, Ivascu C, Qian Y, Rezai S, Okhrimenko A, et al. Loss of methylation at the IFNG promoter and CNS-1 is associated with the development of functional IFN-? memory in human CD4(+) T lymphocytes. Eur J Immunol. 2013;43:793-804 pubmed publisher
    ..Thus, after termination of TCR stimulation, IL-12 signaling potentiates the stable functional IFN-? memory in effector/memory Th1 cells characterized by hypomethylation at the IFNG promoter and CNS-1. ..
  4. Neves E, Curi A, Albuquerque M, Palhano Silva C, Silva L, Bueno W, et al. Genetic polymorphism for IFN? +874T/A in patients with acute toxoplasmosis. Rev Soc Bras Med Trop. 2012;45:757-60 pubmed
    ..This study aimed to evaluate the association of IFN?+874T/A SNP with duration of disease, morbidity, and development of retinochoroiditis in acute toxoplasmosis...
  5. Teixeira A, Mendes C, Marano L, Deghaide N, Secaf M, Elias J, et al. Alleles and genotypes of polymorphisms of IL-18, TNF-? and IFN-? are associated with a higher risk and severity of hepatocellular carcinoma (HCC) in Brazil. Hum Immunol. 2013;74:1024-9 pubmed publisher
    ..Thus, IL-18 -607(*)A and TNF-? (-238(*)A and -308(*)A) alleles may confer susceptibility to HCC, while IL-18 -607(*)C and -137(*)C alleles more severe disease. ..
  6. Dwivedi M, Laddha N, Shah K, Shah B, Begum R. Involvement of interferon-gamma genetic variants and intercellular adhesion molecule-1 in onset and progression of generalized vitiligo. J Interferon Cytokine Res. 2013;33:646-59 pubmed publisher
    ..Moreover, the increased IFN-? levels in patients lead to increased ICAM1 expression, which could be a probable link between cytokines and T-cell involvement in pathogenesis of GV. ..
  7. Saxena R, Chawla Y, Verma I, Kaur J. IFN-? (+874) and not TNF-? (-308) is associated with HBV-HCC risk in India. Mol Cell Biochem. 2014;385:297-307 pubmed publisher
    ..These observations suggest a vital negative association of IFN-? (+874) with HBV-HCC risk, with no significant association evident in TNF-? (-308). However, the TNF-? and IFN-? levels markedly increased in HCC development. ..
  8. Hayes M, Wang J, Norcross M. Regulation of interleukin-12 expression in human monocytes: selective priming by interferon-gamma of lipopolysaccharide-inducible p35 and p40 genes. Blood. 1995;86:646-50 pubmed
    ..The selectivity of priming by IFN-gamma is in accord with a putative role for IL-12 in the initiation and amplification of TH1-type responses. ..
  9. Schoenborn J, Wilson C. Regulation of interferon-gamma during innate and adaptive immune responses. Adv Immunol. 2007;96:41-101 pubmed

More Information

Publications148 found, 100 shown here

  1. Sobti R, Salih A, Nega B, Seyed A, Rupinder K, Vijesh K, et al. Insights into the role of IL-12B and IFN-gamma cytokine gene polymorphisms in HIV-1/AIDS infection. Folia Biol (Praha). 2010;56:110-5 pubmed
    ..The present study suggested that individuals with mutant homozygous IFN-gamma AA genotype were at risk of HIV-1/AIDS (OR = 1.88, 95% CI 1.14-3.10, P = 0.008). ..
  2. Karakus N, Kara N, Ulusoy A, Ozaslan C, Bek Y. Tumor necrosis factor alpha and beta and interferon gamma gene polymorphisms in Turkish breast cancer patients. DNA Cell Biol. 2011;30:371-7 pubmed publisher
    ..between breast cancer and tumor necrosis factor alpha (TNF-?) -308 (G>A), TNF-? +252 (A>G), and interferon gamma (IFN-?) +874 (T>A) gene polymorphisms in a Turkish population...
  3. Gonsky R, Deem R, Targan S. Distinct Methylation of IFNG in the Gut. J Interferon Cytokine Res. 2009;29:407-14 pubmed publisher
    ..These results suggest that the epigenetic methylation status of IFNG may play a mechanistic role in the modulation of cytokine secretion in the mucosa. ..
  4. Stassen N, Leslie Norfleet L, Robertson A, Eichenberger M, Polk H. Interferon-gamma gene polymorphisms and the development of sepsis in patients with trauma. Surgery. 2002;132:289-92 pubmed
    ..This supports the hypothesis that genetic composition plays a role in patient outcome. ..
  5. Selvaraj P, Alagarasu K, Harishankar M, Vidyarani M, Nisha Rajeswari D, Narayanan P. Cytokine gene polymorphisms and cytokine levels in pulmonary tuberculosis. Cytokine. 2008;43:26-33 pubmed publisher
    ..Further, +1188 polymorphism of IL-12B gene either alone or in combination with closely linked genes may regulate IL-12p40 production and may play a major role on acquired immunity to tuberculosis. ..
  6. Collins P, Henderson M, Aune T. Lineage-specific adjacent IFNG and IL26 genes share a common distal enhancer element. Genes Immun. 2012;13:481-8 pubmed publisher
    ..One function of this enhancer is to facilitate recruitment of RNA polymerase II to promoters of both genes. Thus, sharing of distal enhancers between adjacent genes may contribute to evolutionary preservation of gene order. ..
  7. Kumar A, Ghosh B. A single nucleotide polymorphism (A --> G) in intron 3 of IFNgamma gene is associated with asthma. Genes Immun. 2008;9:294-301 pubmed publisher
    ..In conclusion, we report for the first time association of rs1861494 A/G polymorphism with asthma, which may regulate the IFNgamma levels and, hence, modulate asthma pathogenesis. ..
  8. Mosaad Y, Soliman O, Tawhid Z, Sherif D. Interferon-gamma +874 T/A and interleukin-10 -1082 A/G single nucleotide polymorphism in Egyptian children with tuberculosis. Scand J Immunol. 2010;72:358-64 pubmed publisher
    ..IL-10-1082 G/G genotype did not exhibit significant association except for increased GG frequency in PTB. Both cytokine polymorphisms have no relation to tuberculin reaction in patients with TB. ..
  9. Ben Ari Z, Mor E, Papo O, Kfir B, Sulkes J, Tambur A, et al. Cytokine gene polymorphisms in patients infected with hepatitis B virus. Am J Gastroenterol. 2003;98:144-50 pubmed
    ..These findings suggest an association between the genetic ability to produce low levels of IFN-gamma and the susceptibility to develop chronic HBV infection. ..
  10. Albuquerque M, Aleixo A, Benchimol E, Leandro A, das Neves L, Vicente R, et al. The IFN-gamma +874T/A gene polymorphism is associated with retinochoroiditis toxoplasmosis susceptibility. Mem Inst Oswaldo Cruz. 2009;104:451-5 pubmed
    ..gondii infection. ..
  11. Robinson C, O Dee D, Hamilton T, Nau G. Cytokines involved in interferon-gamma production by human macrophages. J Innate Immun. 2010;2:56-65 pubmed publisher
    ..Together, they identify a novel role for IL-27 in regulating macrophage function by disrupting IL-18 activity. ..
  12. Moran A, Ma X, Reich R, Graviss E. No association between the +874T/A single nucleotide polymorphism in the IFN-gamma gene and susceptibility to TB. Int J Tuberc Lung Dis. 2007;11:113-5 pubmed
    ..Given possible sample size limitations, our results suggest that the IFN-gamma +874T/A mutation has no association with TB susceptibility or TB disease severity. ..
  13. McGough J, Yang D, Huang S, Georgi D, Hewitt S, Rocken C, et al. DNA methylation represses IFN-gamma-induced and signal transducer and activator of transcription 1-mediated IFN regulatory factor 8 activation in colon carcinoma cells. Mol Cancer Res. 2008;6:1841-51 pubmed publisher
    ..Our data thus suggest that human colon carcinoma cells silence IFN-gamma-activated IRF8 expression through MBD1-dependent and PIAS1-mediated inhibition of pSTAT1 function at the methylated IRF8 promoter. ..
  14. Zhu Q, Ge Y, Gu S, Yu H, Wang J, Gu X, et al. Relationship between cytokines gene polymorphism and susceptibility to hepatitis B virus intrauterine infection. Chin Med J (Engl). 2005;118:1604-9 pubmed
    ..There was no evident relationship between IL-4 -590 C/T allele SNP and susceptibility to HBV intrauterine infection, but the IL-10 -1082 G allele was associated with preventive efficacy to HBV intrauterine infection. ..
  15. Adamopoulos S, Kolokathis F, Gkouziouta A, Georgiadou P, Chaidaroglou A, Karavolias G, et al. Cytokine gene polymorphisms are associated with markers of disease severity and prognosis in patients with idiopathic dilated cardiomyopathy. Cytokine. 2011;54:68-73 pubmed publisher
    ..014). Specific cytokine gene polymorphisms seem to be associated with worse prognosis as well as with measures of disease severity in DCM. ..
  16. Tso H, Ip W, Chong W, Tam C, Chiang A, Lau Y. Association of interferon gamma and interleukin 10 genes with tuberculosis in Hong Kong Chinese. Genes Immun. 2005;6:358-63 pubmed
    b>Interferon gamma (IFN-gamma) and interleukin 10 (IL-10) are believed to play opposing roles in host immunity against mycobacterial infection...
  17. Hughes T, Tengku Muhammad T, Irvine S, Ramji D. A novel role of Sp1 and Sp3 in the interferon-gamma -mediated suppression of macrophage lipoprotein lipase gene transcription. J Biol Chem. 2002;277:11097-106 pubmed
    ..In contrast, the cytokine decreased the DNA binding activity of Sp1 without affecting the protein levels. These studies therefore reveal a novel mechanism for IFN-gamma-mediated regulation of macrophage gene transcription. ..
  18. Lio D, Marino V, Serauto A, Gioia V, Scola L, Crivello A, et al. Genotype frequencies of the +874T-->A single nucleotide polymorphism in the first intron of the interferon-gamma gene in a sample of Sicilian patients affected by tuberculosis. Eur J Immunogenet. 2002;29:371-4 pubmed
  19. An P, Vlahov D, Margolick J, Phair J, O Brien T, Lautenberger J, et al. A tumor necrosis factor-alpha-inducible promoter variant of interferon-gamma accelerates CD4+ T cell depletion in human immunodeficiency virus-1-infected individuals. J Infect Dis. 2003;188:228-31 pubmed
    ..It is possible that increased IFN-gamma production induced by TNF-alpha when -179T is present causes CD4 cell depletion by apoptosis. ..
  20. Huang Y, Yang H, Borg B, Su X, Rhodes S, Yang K, et al. A functional SNP of interferon-gamma gene is important for interferon-alpha-induced and spontaneous recovery from hepatitis C virus infection. Proc Natl Acad Sci U S A. 2007;104:985-90 pubmed
  21. Liu W, Dan H, Wang Z, Jiang L, Zhou Y, Zhao M, et al. IFN-gamma and IL-4 in saliva of patients with oral lichen planus: a study in an ethnic Chinese population. Inflammation. 2009;32:176-81 pubmed publisher
    ..Imbalance of Th1/Th2 cytokines with Th2-predominant profile in saliva may be involved in OLP. Salivary IL-4 level may be a fine biomarker reflecting the severity of OLP...
  22. Oral H, Budak F, Uzaslan E, Basturk B, Bekar A, Akalin H, et al. Interleukin-10 (IL-10) gene polymorphism as a potential host susceptibility factor in tuberculosis. Cytokine. 2006;35:143-7 pubmed
    ..To confirm the biological significance of our results, further studies should be performed on other population groups. ..
  23. RAICES R, Kannan Y, Sarkar A, Bellamkonda Athmaram V, Wewers M. A synergistic role for IL-1beta and TNFalpha in monocyte-derived IFNgamma inducing activity. Cytokine. 2008;44:234-41 pubmed publisher
    ..These studies demonstrate a synergistic role between TNFalpha and IL-1 family members in the induction of IFNgamma production and give caution to interpretations of KG-1 functional assays designed to detect functional IL-18. ..
  24. Mattarollo S, Rahimpour A, Choyce A, Godfrey D, Leggatt G, Frazer I. Invariant NKT cells in hyperplastic skin induce a local immune suppressive environment by IFN-gamma production. J Immunol. 2010;184:1242-50 pubmed publisher
    ..Thus, inhibition of NKT cell recruitment or function may enable effective immunity against tumor and viral Ags expressed in epithelial cells. ..
  25. Erdei E, Kang H, Meisner A, White K, Pickett G, Baca C, et al. Polymorphisms in cytokine genes and serum cytokine levels among New Mexican women with and without breast cancer. Cytokine. 2010;51:18-24 pubmed publisher
    ..27 and 2.52. Three most statistically significant SNPs were rs2069705, located in the promoter region of the interferon gamma gene (INF-gamma); rs2243248, in the promoter of IL-4 (rs2243248); and rs1800925, in the promoter of the IL-13 ..
  26. Ben Selma W, Harizi H, Bougmiza I, Hannachi N, Ben Kahla I, Zaieni R, et al. Interferon gamma +874T/A polymorphism is associated with susceptibility to active pulmonary tuberculosis development in Tunisian patients. DNA Cell Biol. 2011;30:379-87 pubmed publisher
    b>Interferon gamma (IFN-?) is a key cytokine involved mainly in the defense against intracellular pathogens such as Mycobacterium tuberculosis...
  27. Ma D, Zhu X, Zhao P, Zhao C, Li X, Zhu Y, et al. Profile of Th17 cytokines (IL-17, TGF-beta, IL-6) and Th1 cytokine (IFN-gamma) in patients with immune thrombocytopenic purpura. Ann Hematol. 2008;87:899-904 pubmed publisher
    ..In summary, ITP may not be associated with changes of plasma Th17 and Th1 cytokine concentrations relative to control population. ..
  28. Poli F, Nocco A, Berra S, Scalamogna M, Taioli E, Longhi E, et al. Allele frequencies of polymorphisms of TNFA, IL-6, IL-10 and IFNG in an Italian Caucasian population. Eur J Immunogenet. 2002;29:237-40 pubmed
    ..analysed were those of tumour necrosis factor alpha (TNFA), interleukin 6 (IL-6), interleukin 10 (IL-10) and interferon gamma (IFNG). We found that the frequency of allele TNFA*1 at position -380 was 87.7% and that of TNFA*2 was 12...
  29. Brustoski K, Moller U, Kramer M, Petelski A, Brenner S, Palmer D, et al. IFN-gamma and IL-10 mediate parasite-specific immune responses of cord blood cells induced by pregnancy-associated Plasmodium falciparum malaria. J Immunol. 2005;174:1738-45 pubmed
  30. Kim K, Cho S, Sestak A, Namjou B, Kang C, Bae S. Interferon-gamma gene polymorphisms associated with susceptibility to systemic lupus erythematosus. Ann Rheum Dis. 2010;69:1247-50 pubmed publisher
  31. Daines M, Hershey G. A novel mechanism by which interferon-gamma can regulate interleukin (IL)-13 responses. Evidence for intracellular stores of IL-13 receptor alpha -2 and their rapid mobilization by interferon-gamma. J Biol Chem. 2002;277:10387-93 pubmed
    ..These results provide the first evidence that the IL-13Ralpha2 is predominantly an intracellular molecule and demonstrate a novel mechanism by which IFN-gamma can regulate IL-13 responses. ..
  32. Zielinski C, Mele F, Aschenbrenner D, Jarrossay D, Ronchi F, Gattorno M, et al. Pathogen-induced human TH17 cells produce IFN-? or IL-10 and are regulated by IL-1?. Nature. 2012;484:514-8 pubmed publisher
    ..albicans and S. aureus prime TH17 cells that produce either IFN-? or IL-10, and identify IL-1? and IL-2 as pro- and anti-inflammatory regulators of TH17 cells both at priming and in the effector phase...
  33. Gray P, Goeddel D. Structure of the human immune interferon gene. Nature. 1982;298:859-63 pubmed
    ..All our evidence to date and the present data suggest that this is the only gene for IFN-gamma and that the resolution of IFN-gamma into two components is probably the result of post-translational processing of the protein. ..
  34. Imaizumi T, Kumagai M, Sasaki N, Kurotaki H, Mori F, Seki M, et al. Interferon-gamma stimulates the expression of galectin-9 in cultured human endothelial cells. J Leukoc Biol. 2002;72:486-91 pubmed
    ..IFN-gamma-induced production of galectin-9 by endothelial cells may play an important role in immune responses by regulating interactions between the vascular wall and eosinophils. ..
  35. Fitness J, Floyd S, Warndorff D, Sichali L, Malema S, Crampin A, et al. Large-scale candidate gene study of tuberculosis susceptibility in the Karonga district of northern Malawi. Am J Trop Med Hyg. 2004;71:341-9 pubmed
    ..Genetic susceptibility to TB in Africans appears polygenic. The relevant genes and variants may vary significantly between populations, and may be affected by HIV infection status. ..
  36. Fan X, Zou Z, Long B, Guo Y, Wang S, Jia D, et al. Enhanced demethylation of interferon-? gene promoter in peripheral blood mononuclear cells is associated with acute-on-chronic hepatitis B liver failure. Tohoku J Exp Med. 2011;224:13-9 pubmed
    ..In conclusion, enhanced demethylation of IFN-? gene promoter in PBMCs may be associated with the onset of ACHBLF. ..
  37. Lee D, Avni O, Chen L, Rao A. A distal enhancer in the interferon-gamma (IFN-gamma) locus revealed by genome sequence comparison. J Biol Chem. 2004;279:4802-10 pubmed
    ..Together, these findings identify a highly conserved distal enhancer in the IFN-gamma cytokine locus and validate our approach as a successful method to detect cis-regulatory elements. ..
  38. Zheng T, Kang M, Crothers K, Zhu Z, Liu W, Lee C, et al. Role of cathepsin S-dependent epithelial cell apoptosis in IFN-gamma-induced alveolar remodeling and pulmonary emphysema. J Immunol. 2005;174:8106-15 pubmed
    ..They also link inflammation, protease/antiprotease alterations, and protease-dependent apoptosis in the pathogenesis of Th1/Tc1 cytokine-induced tissue remodeling and destructive responses. ..
  39. Silverberg M, Cho J, Rioux J, McGovern D, Wu J, Annese V, et al. Ulcerative colitis-risk loci on chromosomes 1p36 and 12q15 found by genome-wide association study. Nat Genet. 2009;41:216-20 pubmed publisher
    ..0 x 10(-16), combined OR = 0.66) and at the IL23R locus on chromosome 1p31 (rs11209026, combined P = 1.3 x 10(-8), combined OR = 0.56; rs10889677, combined P = 1.3 x 10(-8), combined OR = 1.29). ..
  40. Etokebe G, Bulat Kardum L, Johansen M, Knezevic J, Balen S, Matakovic Mileusnic N, et al. Interferon-gamma gene (T874A and G2109A) polymorphisms are associated with microscopy-positive tuberculosis. Scand J Immunol. 2006;63:136-41 pubmed
    ..These data suggest an association with disease severity rather than susceptibility to tuberculosis in Croatian Caucasian population. ..
  41. Becknell B, Hughes T, Freud A, Blaser B, Yu J, Trotta R, et al. Hlx homeobox transcription factor negatively regulates interferon-gamma production in monokine-activated natural killer cells. Blood. 2007;109:2481-7 pubmed
    Natural killer (NK) cells contribute to host immunity, including tumor surveillance, through the production of interferon gamma (IFN-gamma)...
  42. Kopinski P, Przybylski G, Jarzemska A, Sładek K, Soja J, Iwaniec T, et al. [Interferon gamma (IFN-gamma) level in broncholaveolar lavage (BAL) fluid is positively correlated with CD4/CD8 ratio in selected interstitial lung diseases]. Pol Merkur Lekarski. 2007;23:15-21 pubmed
    ..CD4+ (Th1), but neither CD8+ (Tc1) nor NK cells seem to be the main local source of IFN-gamma in ILD. Relatively low CD4/CD8 ratio in ILD may indicate the patients with increased risk of lung fibrosis. ..
  43. Gao Q, Liu D, Zhang S, Jia M, Wu L. [Association between IFN-gamma+874 polymorphisms and the clinical outcomes of hepatitis B and/or hepatitis C virus infection.]. Zhonghua Liu Xing Bing Xue Za Zhi. 2010;31:324-8 pubmed
    ..IFN-gamma+874 AA genotype and T allele were possible risk to chronic HBV and/or HCV infections and to the outcomes of HBV and/or HCV infection. However, IFN-gamma+874 TA genotype might serve as possible protective factors to them. ..
  44. Popik W, Hesselgesser J, Pitha P. Binding of human immunodeficiency virus type 1 to CD4 and CXCR4 receptors differentially regulates expression of inflammatory genes and activates the MEK/ERK signaling pathway. J Virol. 1998;72:6406-13 pubmed
  45. Pyo J, Jang M, Kwon Y, Lee H, Jun J, Woo H, et al. Essential roles of Atg5 and FADD in autophagic cell death: dissection of autophagic cell death into vacuole formation and cell death. J Biol Chem. 2005;280:20722-9 pubmed
    ..These results suggest that Atg5 plays a crucial role in IFN-gamma-induced autophagic cell death by interacting with FADD. ..
  46. Ognjanovic S, Yuan J, Chaptman A, Fan Y, Yu M. Genetic polymorphisms in the cytokine genes and risk of hepatocellular carcinoma in low-risk non-Asians of USA. Carcinogenesis. 2009;30:758-62 pubmed publisher
    ..Genetic variants in the interferon gamma (IFNgamma), tumor necrosis factor-alpha (TNFalpha), interleukin-2 (IL-2), IL-4, IL-6, IL-10, IL-12 and IL-18 ..
  47. Thiel D, Le Du M, Walter R, D Arcy A, Chene C, Fountoulakis M, et al. Observation of an unexpected third receptor molecule in the crystal structure of human interferon-gamma receptor complex. Structure. 2000;8:927-36 pubmed
  48. Liu J, Hamrouni A, Wolowiec D, Coiteux V, Kuliczkowski K, Hetuin D, et al. Plasma cells from multiple myeloma patients express B7-H1 (PD-L1) and increase expression after stimulation with IFN-{gamma} and TLR ligands via a MyD88-, TRAF6-, and MEK-dependent pathway. Blood. 2007;110:296-304 pubmed
    ..Thus, B7-H1 expression by MM cells represents a possible immune escape mechanism that could be targeted therapeutically through inhibition of MyD88/TRAF6 and MEK/ERK/STAT1. ..
  49. Dolganiuc A, Norkina O, Kodys K, Catalano D, Bakis G, Marshall C, et al. Viral and host factors induce macrophage activation and loss of toll-like receptor tolerance in chronic HCV infection. Gastroenterology. 2007;133:1627-36 pubmed
  50. Karimi M, Daneshmandi S, Pourfathollah A, Geramizadeh B, Yaghobi R, Rais Jalali G, et al. A study of the impact of cytokine gene polymorphism in acute rejection of renal transplant recipients. Mol Biol Rep. 2012;39:509-15 pubmed publisher
    ..05). Consequently, our results show that IL-6 G-174C and IFN-? T+874A gene polymorphisms have predictive values for acute rejection after renal transplantation in Iranian patients. ..
  51. Pereyra F, Addo M, Kaufmann D, Liu Y, Miura T, Rathod A, et al. Genetic and immunologic heterogeneity among persons who control HIV infection in the absence of therapy. J Infect Dis. 2008;197:563-71 pubmed publisher
    ..Even low-level viremia among HIV controllers was associated with measurable T cell dysfunction, which has implications for current prophylactic vaccine strategies. ..
  52. Duque G, Huang D, Macoritto M, Rivas D, Yang X, Ste Marie L, et al. Autocrine regulation of interferon gamma in mesenchymal stem cells plays a role in early osteoblastogenesis. Stem Cells. 2009;27:550-8 pubmed publisher
    ..These data therefore support a new role for IFNgamma as an autocrine regulator of hMSC differentiation and as a potential new target of bone-forming cells in vivo. ..
  53. Collins P, Chang S, Henderson M, Soutto M, Davis G, McLoed A, et al. Distal regions of the human IFNG locus direct cell type-specific expression. J Immunol. 2010;185:1492-501 pubmed publisher
    ..These results support a model whereby IFNG uses cis-regulatory elements with cell type-restricted function. ..
  54. Vandenbroeck K, Cunningham S, Goris A, Alloza I, Heggarty S, Graham C, et al. Polymorphisms in the interferon-gamma/interleukin-26 gene region contribute to sex bias in susceptibility to rheumatoid arthritis. Arthritis Rheum. 2003;48:2773-8 pubmed
    ..These results conform to our recent observations of a role for this gene cluster in sex-based differential susceptibility to another Th1-type inflammatory disease, multiple sclerosis. ..
  55. Henao M, Montes C, Paris S, Garcia L. Cytokine gene polymorphisms in Colombian patients with different clinical presentations of tuberculosis. Tuberculosis (Edinb). 2006;86:11-9 pubmed
    ..Results suggest that IL-10 low-producer polymorphism and IFN-gamma high-producer polymorphism are associated with pleural TB. ..
  56. Dhillon N, Murphy W, Filla M, Crespo A, Latham H, O Brien Ladner A. Down modulation of IFN-gamma signaling in alveolar macrophages isolated from smokers. Toxicol Appl Pharmacol. 2009;237:22-8 pubmed publisher
    ..Decreased IFN-gamma signal transduction in AM from smokers may have an important implication regarding the use of therapeutic IFN-gamma in the lungs of patients that develop respiratory disorders as a result of tobacco use...
  57. McCall M, Hopman J, Daou M, Maiga B, Dara V, Ploemen I, et al. Early interferon-gamma response against Plasmodium falciparum correlates with interethnic differences in susceptibility to parasitemia between sympatric Fulani and Dogon in Mali. J Infect Dis. 2010;201:142-52 pubmed publisher
    ..falciparum as a correlate of anti-parasite immunity, not only in this setting but also in the wider context of malaria, and support the development of malaria vaccines aimed at inducing such responses. ..
  58. Chevillard C, Moukoko C, Elwali N, Bream J, Kouriba B, Argiro L, et al. IFN-gamma polymorphisms (IFN-gamma +2109 and IFN-gamma +3810) are associated with severe hepatic fibrosis in human hepatic schistosomiasis (Schistosoma mansoni). J Immunol. 2003;171:5596-601 pubmed
    ..Together, these observations support the view that IFN-gamma expression and subsequent signal transduction play a critical role in the control of PPF in human hepatic schistosome infection (S. mansoni). ..
  59. Harigai M, Kawamoto M, Hara M, Kubota T, Kamatani N, Miyasaka N. Excessive production of IFN-gamma in patients with systemic lupus erythematosus and its contribution to induction of B lymphocyte stimulator/B cell-activating factor/TNF ligand superfamily-13B. J Immunol. 2008;181:2211-9 pubmed
  60. Tian C, Zhang Y, Zhang J, Deng Y, Li X, Xu D, et al. The +874T/A polymorphism in the interferon-? gene and tuberculosis risk: an update by meta-analysis. Hum Immunol. 2011;72:1137-42 pubmed publisher
    ..71, 95% CI = 0.52-0.97, p = 0.03) but not in Caucasians (OR = 0.87, 95% CI = 0.65-1.17, p = 0.37). Our results suggest that the IFN-? +874T/A polymorphism contributes to susceptibility to TB. ..
  61. Kimkong I, Nakkuntod J, Sodsai P, Hirankarn N, Kitkumthorn N. Association of interferon-gamma gene polymorphisms with susceptibility to oral lichen planus in the Thai population. Arch Oral Biol. 2012;57:491-4 pubmed publisher
    ..However, an association study utilising a larger sample size and patients from other races apart from the Asian population should be performed to further verify these findings. ..
  62. Landar A, Curry B, Parker M, DiGiacomo R, Indelicato S, Nagabhushan T, et al. Design, characterization, and structure of a biologically active single-chain mutant of human IFN-gamma. J Mol Biol. 2000;299:169-79 pubmed
    ..The current data are consistent with the main role of the IFN-gamma dimer being to decrease the dissociation constant of IFN-gamma for its cellular receptors. ..
  63. Kerr J, McCoy M, Burke B, Mattey D, Pravica V, Hutchinson I. Cytokine gene polymorphisms associated with symptomatic parvovirus B19 infection. J Clin Pathol. 2003;56:725-7 pubmed
    ..were examined for the following cytokine polymorphisms: tumour necrosis factor alpha (TNF alpha), -308; interferon gamma (IFN-gamma), +874; interleukin 6 (IL-6), -174; IL-10, -592, -819, and -1082; and transforming growth factor ..
  64. Pehlivan M, Okan V, Sever T, Balci S, Yilmaz M, Babacan T, et al. Investigation of TNF-alpha, TGF-beta 1, IL-10, IL-6, IFN-gamma, MBL, GPIA, and IL1A gene polymorphisms in patients with idiopathic thrombocytopenic purpura. Platelets. 2011;22:588-95 pubmed publisher
  65. Vasilescu A, Heath S, Ivanova R, Hendel H, Do H, Mazoyer A, et al. Genomic analysis of Th1-Th2 cytokine genes in an AIDS cohort: identification of IL4 and IL10 haplotypes associated with the disease progression. Genes Immun. 2003;4:441-9 pubmed
    ..The catalogue of SNP and haplotypes presented here will facilitate further genetic investigations of Th1-Th2 cytokines in AIDS and other immune-related disorders. ..
  66. Ahmed C, Johnson H. IFN-gamma and its receptor subunit IFNGR1 are recruited to the IFN-gamma-activated sequence element at the promoter site of IFN-gamma-activated genes: evidence of transactivational activity in IFNGR1. J Immunol. 2006;177:315-21 pubmed
  67. Sallakci N, Coskun M, Berber Z, Gurkan F, Kocamaz H, Uysal G, et al. Interferon-gamma gene+874T-A polymorphism is associated with tuberculosis and gamma interferon response. Tuberculosis (Edinb). 2007;87:225-30 pubmed
    ..Our data suggest that similar to various Caucasian populations, in a Turkish population the IFN-gamma+874 T-A polymorphism is also associated with tuberculosis disease and affects the magnitude of the IFN-gamma response. ..
  68. Baron M, Davignon J. Inhibition of IFN-gamma-induced STAT1 tyrosine phosphorylation by human CMV is mediated by SHP2. J Immunol. 2008;181:5530-6 pubmed
    ..Our data suggest that SHP2 activation induced by HCMV infection is responsible for the down-regulation of IFN-gamma-induced STAT1 tyrosine phosphorylation. ..
  69. Knoblach T, Grandel B, Seiler J, Nevels M, Paulus C. Human cytomegalovirus IE1 protein elicits a type II interferon-like host cell response that depends on activated STAT1 but not interferon-?. PLoS Pathog. 2011;7:e1002016 pubmed publisher
  70. Aabye M, Ravn P, Johansen I, Eugen Olsen J, Ruhwald M. Incubation of whole blood at 39°C augments gamma interferon (IFN-?)-induced protein 10 and IFN-? responses to Mycobacterium tuberculosis antigens. Clin Vaccine Immunol. 2011;18:1150-6 pubmed publisher
    ..Incubation at fever-range temperature vividly increases CMI responsiveness to antigen stimulation in vitro in tuberculosis patients and may increase the sensitivity of CMI assays. ..
  71. Bream J, Ping A, Zhang X, Winkler C, Young H. A single nucleotide polymorphism in the proximal IFN-gamma promoter alters control of gene transcription. Genes Immun. 2002;3:165-9 pubmed
    ..The -179T allele identified in the proximal IFN-gamma promoter confers TNF-alpha inducibility and may prove important in human immune disorders and responsiveness to pathogens. ..
  72. Heller N, Matsukura S, Georas S, Boothby M, Rothman P, Stellato C, et al. Interferon-gamma inhibits STAT6 signal transduction and gene expression in human airway epithelial cells. Am J Respir Cell Mol Biol. 2004;31:573-82 pubmed
    ..These observations have important implications for the regulation of epithelial cell activation by the balance of Th1/Th2-type cytokines in the airways in allergic disease. ..
  73. Dai C, Chuang W, Hsieh M, Lee L, Hou N, Chen S, et al. Polymorphism of interferon-gamma gene at position +874 and clinical characteristics of chronic hepatitis C. Transl Res. 2006;148:128-33 pubmed
    ..519/1.128-5.622 and 1.065 /1.025-1.107, respectively). In conclusion, the authors' findings indicate that inheritance of +847 IFN-gamma polymorphism is associated with the cirrhosis in patients with CHC. ..
  74. Ansari A, Talat N, Jamil B, Hasan Z, Razzaki T, Dawood G, et al. Cytokine gene polymorphisms across tuberculosis clinical spectrum in Pakistani patients. PLoS ONE. 2009;4:e4778 pubmed publisher
    ..26; p = 0.005) and DTB (OR = 3.59; p = 0.045). These findings are consistent with the role of IL10 in reducing collateral tissue damage and the protective role of IFNgamma in limiting disease in the lung. ..
  75. Kaur G, Rapthap C, Kumar N, Kumar S, Neolia S, Mehra N. Frequency distribution of cytokine gene polymorphisms in the healthy North Indian population. Tissue Antigens. 2007;69:113-20 pubmed
    ..The data can be used for anthropological comparisons, as well as for association studies with different diseases and for use in transplant situations involving acute and chronic rejection. ..
  76. Matos G, Covas C, Bittar R, Gomes Silva A, Marques F, Maniero V, et al. IFNG +874T/A polymorphism is not associated with American tegumentary leishmaniasis susceptibility but can influence Leishmania induced IFN-gamma production. BMC Infect Dis. 2007;7:33 pubmed
    ..On the other hand, it is possible that in ML cases, other potential polymorphic regulatory genes such as TNF-alpha and IL-10 are also involved thus interfering with IFN-gamma secretion. ..
  77. Hadjur S, Williams L, Ryan N, Cobb B, Sexton T, Fraser P, et al. Cohesins form chromosomal cis-interactions at the developmentally regulated IFNG locus. Nature. 2009;460:410-3 pubmed publisher
    ..This new aspect of cohesin function is probably important for normal development and disease. ..
  78. Li J, Yim H, Lau A. Role of HIV-1 Tat in AIDS pathogenesis: its effects on cytokine dysregulation and contributions to the pathogenesis of opportunistic infection. AIDS. 2010;24:1609-23 pubmed publisher
  79. Chang H, Zeng F, Zhang J, Mu X, Meng W, Ma H, et al. Association of the interferon-gamma single nucleotide polymorphism +874(T/A) with response to immunosuppressive therapy in patients with severe aplastic anemia. Blood Cells Mol Dis. 2010;45:313-6 pubmed publisher
    ..3% vs. IFN-? +874 non-TT 35%, p<0.05). In conclusion, the IFN-? +874T/A gene polymorphism may be correlated with response to immunosuppressive therapy. ..
  80. Deiss L, Feinstein E, Berissi H, Cohen O, Kimchi A. Identification of a novel serine/threonine kinase and a novel 15-kD protein as potential mediators of the gamma interferon-induced cell death. Genes Dev. 1995;9:15-30 pubmed
    ..Altogether, it is suggested that these two novel genes are candidates for positive mediators of programmed cell death that is induced by IFN-gamma. ..
  81. Yano S, Ghosh P, Kusaba H, Buchholz M, Longo D. Effect of promoter methylation on the regulation of IFN-gamma gene during in vitro differentiation of human peripheral blood T cells into a Th2 population. J Immunol. 2003;171:2510-6 pubmed
    ..This results in the increased production of IFN-gamma. These data indicate the importance of promoter methylation in the regulation of the IFN-gamma gene during differentiation. ..
  82. Nagineni C, Cherukuri K, Kutty V, Detrick B, Hooks J. Interferon-gamma differentially regulates TGF-beta1 and TGF-beta2 expression in human retinal pigment epithelial cells through JAK-STAT pathway. J Cell Physiol. 2007;210:192-200 pubmed
    ..Our data demonstrate that IFN-gamma differentially regulates constitutively expressed, as well as, cytokine-induced TGF-beta1 and TGF-beta2 mRNA levels and secretion of TGF-betas by HRPE. ..
  83. Hu Y, Dutz J, MacCalman C, Yong P, Tan R, von Dadelszen P. Decidual NK cells alter in vitro first trimester extravillous cytotrophoblast migration: a role for IFN-gamma. J Immunol. 2006;177:8522-30 pubmed
    ..dNK cell effects were partially reversed by neutralizing Abs against IFN-gamma. We provide ex vivo human evidence of a direct role for dNK in modulating EVT differentiation as they form columns and then migrate from anchoring villi. ..
  84. Sam Agudu N, Greene J, Opoka R, Kazura J, Boivin M, Zimmerman P, et al. TLR9 polymorphisms are associated with altered IFN-gamma levels in children with cerebral malaria. Am J Trop Med Hyg. 2010;82:548-55 pubmed publisher
    ..We present the first human data that TLR SNPs are associated with altered cytokine production in parasitic infection. ..
  85. Ealick S, Cook W, Vijay Kumar S, Carson M, Nagabhushan T, Trotta P, et al. Three-dimensional structure of recombinant human interferon-gamma. Science. 1991;252:698-702 pubmed
    ..The dimeric structure of human interferon-gamma is stabilized by the intertwining of helices across the subunit interface with multiple intersubunit interactions. ..
  86. Liu M, Cao B, Zhang H, Dai Y, Liu X, Xu C. Association of interferon-gamma gene haplotype in the Chinese population with hepatitis B virus infection. Immunogenetics. 2006;58:859-64 pubmed
    ..b>Interferon gamma (IFN-gamma) produced by T lymphocytes and natural killer cells plays an essential role in affecting cellular ..
  87. Vallinoto A, Graça E, Araújo M, Azevedo V, Cayres Vallinoto I, Machado L, et al. IFNG +874T/A polymorphism and cytokine plasma levels are associated with susceptibility to Mycobacterium tuberculosis infection and clinical manifestation of tuberculosis. Hum Immunol. 2010;71:692-6 pubmed publisher
    ..Thus our findings suggest an association of the IFNG +874T/A polymorphism with susceptibility to M. tuberculosis infection in the studied population. ..
  88. Quaranta M, Camponeschi B, Straface E, Malorni W, Viora M. Induction of interleukin-15 production by HIV-1 nef protein: a role in the proliferation of uninfected cells. Exp Cell Res. 1999;250:112-21 pubmed
    ..Our results might suggest that Nef enhances the rate of viral replication by a novel mechanism involving the production of IL-15. ..
  89. Bream J, Hodge D, Gonsky R, Spolski R, Leonard W, Krebs S, et al. A distal region in the interferon-gamma gene is a site of epigenetic remodeling and transcriptional regulation by interleukin-2. J Biol Chem. 2004;279:41249-57 pubmed
    ..These data led us to conclude that this distal region serves as both a target of chromatin remodeling in the IFNG locus as well as an IL-2-induced transcriptional enhancer that binds Stat5 proteins. ..
  90. Nieters A, Yuan J, Sun C, Zhang Z, Stoehlmacher J, Govindarajan S, et al. Effect of cytokine genotypes on the hepatitis B virus-hepatocellular carcinoma association. Cancer. 2005;103:740-8 pubmed
    ..Relative to the putative high-activity genotypes, each individual low-activity genotype of interferon gamma, interleukin 12 (IL12), and IL18 was associated with a statistically nonsignificant increase (40-60%) in the ..
  91. Kampmann B, Hemingway C, Stephens A, Davidson R, Goodsall A, Anderson S, et al. Acquired predisposition to mycobacterial disease due to autoantibodies to IFN-gamma. J Clin Invest. 2005;115:2480-8 pubmed
    ..Acquired defects in the IFN-gamma pathway may explain unusual susceptibility to intracellular pathogens in other patients without underlying, genetically determined immunological defects. ..
  92. Amim L, Pacheco A, Fonseca Costa J, Loredo C, Rabahi M, Melo M, et al. Role of IFN-gamma +874 T/A single nucleotide polymorphism in the tuberculosis outcome among Brazilians subjects. Mol Biol Rep. 2008;35:563-6 pubmed