HTRA1

Summary

Gene Symbol: HTRA1
Description: HtrA serine peptidase 1
Alias: ARMD7, CADASIL2, CARASIL, HtrA, L56, ORF480, PRSS11, serine protease HTRA1, IGFBP5-protease, high-temperature requirement A serine peptidase 1, protease, serine, 11 (IGF binding)
Species: human

Top Publications

  1. ncbi Safety and immune responses to attenuated Salmonella enterica serovar typhi oral live vector vaccines expressing tetanus toxin fragment C
    C O Tacket
    Center for Vaccine Development, University of Maryland School of Medicine, 685 West Baltimore Street, Baltimore, Maryland 21201, USA
    Clin Immunol 97:146-53. 2000
  2. pmc Alleles in the HtrA serine peptidase 1 gene alter the risk of neovascular age-related macular degeneration
    Margaret M DeAngelis
    Department of Ophthalmology, Harvard Medical School, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts 02114, USA
    Ophthalmology 115:1209-1215.e7. 2008
  3. ncbi Distribution of the serine protease HtrA1 in normal human tissues
    Antonio De Luca
    Department of Medicine and Public Health, Section of Clinical Anatomy, Second University of Naples, Naples, Italy
    J Histochem Cytochem 51:1279-84. 2003
  4. pmc Implications of the serine protease HtrA1 in amyloid precursor protein processing
    Sandra Grau
    School of Biosciences, Cardiff University, Cardiff CF10 3US, United Kingdom
    Proc Natl Acad Sci U S A 102:6021-6. 2005
  5. doi Substrate-induced remodeling of the active site regulates human HTRA1 activity
    Linda Truebestein
    Centre for Medical Biotechnology, Faculty of Biology, University Duisburg Essen, Essen, Germany
    Nat Struct Mol Biol 18:386-8. 2011
  6. ncbi LOC387715/HTRA1 variants in polypoidal choroidal vasculopathy and age-related macular degeneration in a Japanese population
    Naoshi Kondo
    Department of Organs Therapeutics, Division of Ophthalmology, Kobe University Graduate School of Medicine, Kobe, Japan
    Am J Ophthalmol 144:608-12. 2007
  7. ncbi Expression pattern alterations of the serine protease HtrA1 in normal human placental tissues and in gestational trophoblastic diseases
    Daniela Marzioni
    Department of Molecular Pathology and Innovative Therapies, Faculty of Medicine, Polytechnic University of Marche, Ancona, Italy
    Histol Histopathol 24:1213-22. 2009
  8. pmc High temperature requirement factor A1 (HTRA1) gene regulates angiogenesis through transforming growth factor-β family member growth differentiation factor 6
    Li Zhang
    Molecular Medicine Research Center and Department of Ophthalmology, West China Hospital, Sichuan University, Chengdu 610041, China
    J Biol Chem 287:1520-6. 2012
  9. pmc Detrimental role for human high temperature requirement serine protease A1 (HTRA1) in the pathogenesis of intervertebral disc (IVD) degeneration
    André N Tiaden
    Bone and Stem Cell Research Group, Center for Applied Biotechnology and Molecular Medicine, University of Zurich, 8057 Zurich, Switzerland
    J Biol Chem 287:21335-45. 2012
  10. pmc Binding of proteins to the PDZ domain regulates proteolytic activity of HtrA1 serine protease
    - Murwantoko
    Division of Gene Function in Animals, Nara Institute of Science and Technology, 891605 Takayama, Ikoma, Nara 630 0101, Japan
    Biochem J 381:895-904. 2004

Research Grants

  1. Building a Better AMD Mouse
    Caroline J Zeiss; Fiscal Year: 2010
  2. Characterizing Exportal by a Polymyxin B Resistance-Based Mutagenic Approach
    Luis Alberto Vega; Fiscal Year: 2010
  3. Functional analysis of AMD-associated HTRA1 promoter polymorphism
    Noriko Esumi; Fiscal Year: 2010
  4. Genetic Epidemiology of Age-Related Macular Degeneration
    Debra A Schaumberg; Fiscal Year: 2011
  5. Regulation of Serine Protease HtrA1 and Chemoresponse
    Viji Shridhar; Fiscal Year: 2012
  6. Robert T Sauer; Fiscal Year: 2016
  7. Genetics and Functional Studies of Age-Related Macular Degeneration
    Kang Zhang; Fiscal Year: 2012
  8. Validation and development of specific small molecule inhibitors of HTRA1 for tre
    Shuyuan Yao; Fiscal Year: 2010
  9. SIBLING STUDY OF AGE-RELATED MACULAR DEGENERATION
    Margaret M DeAngelis; Fiscal Year: 2010
  10. Ashok K Chopra; Fiscal Year: 2015

Detail Information

Publications195 found, 100 shown here

  1. ncbi Safety and immune responses to attenuated Salmonella enterica serovar typhi oral live vector vaccines expressing tetanus toxin fragment C
    C O Tacket
    Center for Vaccine Development, University of Maryland School of Medicine, 685 West Baltimore Street, Baltimore, Maryland 21201, USA
    Clin Immunol 97:146-53. 2000
    Attenuated Salmonella enterica serovar Typhi vaccine strain CVD 908-htrA was used as a vector to deliver fragment C of tetanus toxin as a single-dose oral tetanus vaccine candidate to elicit protective levels of serum tetanus antitoxin...
  2. pmc Alleles in the HtrA serine peptidase 1 gene alter the risk of neovascular age-related macular degeneration
    Margaret M DeAngelis
    Department of Ophthalmology, Harvard Medical School, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts 02114, USA
    Ophthalmology 115:1209-1215.e7. 2008
    ..domain-containing protein gene (PLEKHA1), hypothetical LOC387715/ARMS2 gene, and HtrA serine peptidase 1 gene (HTRA1) located on the long arm of chromosome 10 (10q26 region) confer risk for neovascular age-related macular ..
  3. ncbi Distribution of the serine protease HtrA1 in normal human tissues
    Antonio De Luca
    Department of Medicine and Public Health, Section of Clinical Anatomy, Second University of Naples, Naples, Italy
    J Histochem Cytochem 51:1279-84. 2003
    The human HtrA family of proteases consists of three members: HtrA1, HtrA2, and HtrA3...
  4. pmc Implications of the serine protease HtrA1 in amyloid precursor protein processing
    Sandra Grau
    School of Biosciences, Cardiff University, Cardiff CF10 3US, United Kingdom
    Proc Natl Acad Sci U S A 102:6021-6. 2005
    ..Our data suggest that HtrA1 is directly involved in the beta-amyloid pathway as it degrades various fragments of amyloid precursor protein ..
  5. doi Substrate-induced remodeling of the active site regulates human HTRA1 activity
    Linda Truebestein
    Centre for Medical Biotechnology, Faculty of Biology, University Duisburg Essen, Essen, Germany
    Nat Struct Mol Biol 18:386-8. 2011
    Crystal structures of active and inactive conformations of the human serine protease HTRA1 reveal that substrate binding to the active site is sufficient to stimulate proteolytic activity...
  6. ncbi LOC387715/HTRA1 variants in polypoidal choroidal vasculopathy and age-related macular degeneration in a Japanese population
    Naoshi Kondo
    Department of Organs Therapeutics, Division of Ophthalmology, Kobe University Graduate School of Medicine, Kobe, Japan
    Am J Ophthalmol 144:608-12. 2007
    To investigate whether variants in the LOC387715 locus and the HtrA serine peptidase 1 (HTRA1) gene within the 10q26 locus are associated with polypoidal choroidal vasculopathy (PCV) and wet age-related macular degeneration (AMD) in a ..
  7. ncbi Expression pattern alterations of the serine protease HtrA1 in normal human placental tissues and in gestational trophoblastic diseases
    Daniela Marzioni
    Department of Molecular Pathology and Innovative Therapies, Faculty of Medicine, Polytechnic University of Marche, Ancona, Italy
    Histol Histopathol 24:1213-22. 2009
    b>HtrA1 is a secreted protein which behaves as a molecular chaperone at low temperatures and as a serine protease at high temperatures...
  8. pmc High temperature requirement factor A1 (HTRA1) gene regulates angiogenesis through transforming growth factor-β family member growth differentiation factor 6
    Li Zhang
    Molecular Medicine Research Center and Department of Ophthalmology, West China Hospital, Sichuan University, Chengdu 610041, China
    J Biol Chem 287:1520-6. 2012
    ..study (GWAS) has identified genetic variants in the promoter region of the high temperature requirement factor A1 (HTRA1) gene associated with age-related macular degeneration (AMD)...
  9. pmc Detrimental role for human high temperature requirement serine protease A1 (HTRA1) in the pathogenesis of intervertebral disc (IVD) degeneration
    André N Tiaden
    Bone and Stem Cell Research Group, Center for Applied Biotechnology and Molecular Medicine, University of Zurich, 8057 Zurich, Switzerland
    J Biol Chem 287:21335-45. 2012
    Human HTRA1 is a highly conserved secreted serine protease that degrades numerous extracellular matrix proteins...
  10. pmc Binding of proteins to the PDZ domain regulates proteolytic activity of HtrA1 serine protease
    - Murwantoko
    Division of Gene Function in Animals, Nara Institute of Science and Technology, 891605 Takayama, Ikoma, Nara 630 0101, Japan
    Biochem J 381:895-904. 2004
    b>HtrA1, a member of the mammalian HtrA (high temperature requirement A) serine protease family, has a highly conserved protease domain followed by a PDZ domain...
  11. pmc Neovascular age-related macular degeneration risk based on CFH, LOC387715/HTRA1, and smoking
    Anne E Hughes
    Department of Medical Genetics, Queen s University Belfast, Belfast, United Kingdom
    PLoS Med 4:e355. 2007
    ..Polymorphisms in the complement factor H (CFH) gene, LOC387715, and the HTRA1 promoter are strongly associated with AMD. Smoking also contributes to the etiology...
  12. ncbi The role of human HtrA1 in arthritic disease
    Sandra Grau
    School of Biosciences, Cardiff University, Cardiff CF10 3US, United Kingdom
    J Biol Chem 281:6124-9. 2006
    Human HtrA1 belongs to a widely conserved family of serine proteases involved in various aspects of protein quality control and cell fate...
  13. pmc HTRA1 promoter polymorphism predisposes Japanese to age-related macular degeneration
    Tsunehiko Yoshida
    National Institute of Sensory Organs, National Hospital Organization Tokyo Medical Center, Tokyo, Japan
    Mol Vis 13:545-8. 2007
    ..To study the effect of candidate single nucleotide polymorphisms (SNPs) on chromosome 10q26, recently shown to be associated with wet age-related macular degeneration (AMD) in Chinese and Caucasian cohorts, in a Japanese cohort...
  14. ncbi Association of the HTRA1 -625G>A promoter gene polymorphism with exudative age-related macular degeneration in a Central European population
    Martin Weger
    Department of Ophthalmology, Medical University of Graz, Austria
    Mol Vis 13:1274-9. 2007
    ..Recently, the HTRA1 -625A allele was identified as a novel risk marker in both a North American and a Chinese population...
  15. ncbi Serine proteases HTRA1 and HTRA3 are down-regulated with increasing grades of human endometrial cancer
    Marissa A Bowden
    Prince Henry s Institute of Medical Research, P O Box 5152, Clayton, Victoria 3168, Australia
    Gynecol Oncol 103:253-60. 2006
    ..Four human HTRA members have been described: HTRA1-4. HTRA1 and HTRA3 share a high degree of domain homologies and may therefore share a functional similarity...
  16. ncbi A variant of the HTRA1 gene increases susceptibility to age-related macular degeneration
    Zhenglin Yang
    Department of Ophthalmology and Visual Sciences, Moran Eye Center, University of Utah School of Medicine, Salt Lake City, UT 84132, USA
    Science 314:992-3. 2006
    ..We demonstrate that a single-nucleotide polymorphism, rs11200638, in the promoter region of HTRA1 is the most likely causal variant for AMD at 10q26 and is estimated to confer a population attributable risk of 49...
  17. ncbi Distinct expression and localization of serine protease HtrA1 in human endometrium and first-trimester placenta
    Guiying Nie
    Prince Henry s Institute of Medical Research, Clayton, Victoria, Australia
    Dev Dyn 235:3448-55. 2006
    ..b>HtrA1 is a member of the recently identified mammalian HtrA (high temperature requirement factor A) serine protease ..
  18. ncbi [Characterization of the HtrA family of proteins]
    Dorota Zurawa-Janicka
    Katedra Biochemii, Instytut Biologii, Uniwersytet Gdanski, Gdansk
    Postepy Biochem 53:27-36. 2007
    The HtrA family of proteins consists of evolutionary conserved serine proteases, which are homologues of the HtrA protein from a model bacterium Escherichia coli...
  19. ncbi PLEKHA1-LOC387715-HTRA1 polymorphisms and exudative age-related macular degeneration in the French population
    Nicolas Leveziel
    Creteil University Eye Clinic, Faculte de Medecine Henri Mondor, Creteil, France
    Mol Vis 13:2153-9. 2007
    ..Exudative AMD is rapidly progressive and usually associated with severe prognosis. Our purpose was to investigate this association on locus 10q26 in a case-control study including French patients specifically affected with exudative AMD...
  20. doi Further mapping of 10q26 supports strong association of HTRA1 polymorphisms with age-related macular degeneration
    Daniel Gibbs
    Department of Ophthalmology and Visual Science, Moran Eye Center, Building 533, Room 3160A, 15 North 2030 East, Salt Lake City, UT 84132, USA
    Vision Res 48:685-9. 2008
    ..A polymorphism (rs11200638) in a transcription factor binding site of the HTRA1 gene has been described, in previous reports, as being most significantly associated with AMD...
  21. pmc Association of CFH, LOC387715, and HTRA1 polymorphisms with exudative age-related macular degeneration in a northern Chinese population
    Yule Xu
    Beijing Tongren Eye Center, Capital Medical University, Beijing, China
    Mol Vis 14:1373-81. 2008
    Variants in complement factor H (CFH), the hypothetical LOC387715, and the high-temperature requirement A-1 (HTRA1) genes have been reported to be associated with age-related macular degeneration (AMD)...
  22. pmc Identification of tubulins as substrates of serine protease HtrA1 by mixture-based oriented peptide library screening
    Jeremy Chien
    Department of Experimental Pathology, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA
    J Cell Biochem 107:253-63. 2009
    b>Serine protease HtrA1 belongs to a family of chymotrypsin-like proteases that were first identified in bacteria and later in mammalian systems...
  23. doi Association of HTRA1 mutations and familial ischemic cerebral small-vessel disease
    Kenju Hara
    Niigata University, Niigata, Japan
    N Engl J Med 360:1729-39. 2009
    The genetic cause of cerebral autosomal recessive arteriopathy with subcortical infarcts and leukoencephalopathy (CARASIL), which is characterized by ischemic, nonhypertensive, cerebral small-vessel disease with associated alopecia and ..
  24. pmc C-reactive protein and CFH, ARMS2/HTRA1 gene variants are independently associated with risk of macular degeneration
    Johanna M Seddon
    Ophthalmic Epidemiology and Genetics Service, Department of Ophthalmology, Tufts Medical Center, Tufts University School of Medicine, Boston, Massachusetts, USA
    Ophthalmology 117:1560-6. 2010
    Genetic variants CFH and ARMS2/HTRA1 gene regions as well as high-sensitivity C-reactive protein (CRP) levels are related to age-related macular degeneration (AMD)...
  25. doi Complement factor H and high-temperature requirement A-1 genotypes and treatment response of age-related macular degeneration
    Takashi Tsuchihashi
    Department of Ophthalmology, Saitama Medical University, Iruma, Saitama, Japan
    Ophthalmology 118:93-100. 2011
    To determine whether there is an association between complement factor H (CFH), high-temperature requirement A-1 (HTRA1), vascular endothelial growth factor (VEGF), and pigment epithelium-derived factor (PEDF) genotypes and response to ..
  26. pmc Human high temperature requirement serine protease A1 (HTRA1) degrades tau protein aggregates
    Annette Tennstaedt
    Centre for Medical Biotechnology, Faculty of Biology, University Duisburg Essen, Universitaetsstrasse, 45141 Essen, Germany
    J Biol Chem 287:20931-41. 2012
    ..So far, however, no HtrA protease is known that degrades protein aggregates. We show here that human HTRA1 degrades aggregated and fibrillar tau, a protein that is critically involved in various neurological disorders...
  27. ncbi Primary structure of a putative serine protease specific for IGF-binding proteins
    J Zumbrunn
    M E Müller Institut für Biomechanik, Universitat Bern, Switzerland
    FEBS Lett 398:187-92. 1996
    ..This protein has a molecular mass of 51 kDa and is highly related to the HtrA family of serine proteases from bacteria...
  28. ncbi Human HtrA, an evolutionarily conserved serine protease identified as a differentially expressed gene product in osteoarthritic cartilage
    S I Hu
    Arthritis Biology Unit, Novartis Pharmaceuticals, Summit, New Jersey 07901, USA
    J Biol Chem 273:34406-12. 1998
    The human homologue of the Escherichia coli htrA gene product was identified by the differential display analysis of transcripts expressed in osteoarthritic cartilage...
  29. ncbi The HtrA1 serine protease is down-regulated during human melanoma progression and represses growth of metastatic melanoma cells
    Alfonso Baldi
    Laboratory C, CRS, Regina Elena Cancer Institute, Rome, Italy
    Oncogene 21:6684-8. 2002
    ..lymph node metastasis using cDNA arrays indicated down-regulation of PRSS11, a gene encoding the serine protease HtrA1, a homolog of the Escherichia coli protease HtrA, in the metastatic line...
  30. ncbi A candidate tumor suppressor HtrA1 is downregulated in ovarian cancer
    Jeremy Chien
    Mayo Clinic Cancer Center and Department of Experimental Pathology, Mayo Clinic, Rochester, MN 55905, USA
    Oncogene 23:1636-44. 2004
    We report here that HtrA1, a candidate tumor suppressor, is downregulated in ovarian cancer. Expression of HtrA1 is downregulated in five of seven ovarian cancer cell lines...
  31. ncbi HtrA1 serine protease inhibits signaling mediated by Tgfbeta family proteins
    Chio Oka
    Division of Gene Function in Animals, Nara Institute of Science and Technology, 8916 5 Takayama, Ikoma, Nara 630 0101, Japan
    Development 131:1041-53. 2004
    b>HtrA1, a member of the mammalian HtrA serine protease family, has a highly conserved protease domain followed by a PDZ domain...
  32. pmc Serine protease HtrA1 modulates chemotherapy-induced cytotoxicity
    Jeremy Chien
    Department of Laboratory Medicine and Experimental Pathology, Mayo Clinic College of Medicine, Rochester, Minnesota 55905, USA, Medical Oncology Unit and Department of Histopathology, San Salvatore Hospital, Pesaro, Italy
    J Clin Invest 116:1994-2004. 2006
    ..These findings uncover what we believe to be a novel pathway by which serine protease HtrA1 mediates paclitaxel- and cisplatin-induced cytotoxicity and suggest that loss of HtrA1 in ovarian and ..
  33. ncbi HTRA1 promoter polymorphism in wet age-related macular degeneration
    Andrew Dewan
    Department of Epidemiology and Public Health, Yale University, 60 College Street, New Haven, CT 06520, USA
    Science 314:989-92. 2006
    ..Here we report that a single-nucleotide polymorphism in the promoter region of HTRA1, a serine protease gene on chromosome 10q26, is a major genetic risk factor for wet AMD...
  34. ncbi Analysis of HtrA1 serine protease expression in human lung cancer
    Vincenzo Esposito
    Third Division, Cotugno Hospital, Naples, Italy
    Anticancer Res 26:3455-9. 2006
    b>HtrA1 is a serine protease homologue to the bacterial serine-protease HtrA, also known as DegP, a heat shock-induced envelope-associated serine protease...
  35. ncbi HTRA1 variant confers similar risks to geographic atrophy and neovascular age-related macular degeneration
    D Joshua Cameron
    Department of Ophthalmology and Visual Sciences, Moran Eye Center, University of Utah School of Medicine, Salt Lake City, Utah, USA
    Cell Cycle 6:1122-5. 2007
    ..A single nucleotide polymorphism, rs11200638, in the promoter of HTRA1 has been shown to increases the risk for wet AMD...
  36. ncbi Association of the HTRA1 gene variant with age-related macular degeneration in the Japanese population
    Keisuke Mori
    Department of Ophthalmology, Saitama Medical University, Faculty of Medicine, 38 Morohongo, Moroyama, Iruma, Saitama, 350 0495, Japan
    J Hum Genet 52:636-41. 2007
    The purpose of this investigation was to determine whether the high-temperature requirement A-1 (HTRA1) gene polymorphism is associated with age-related macular degeneration (AMD) in native, unrelated Japanese patients...
  37. pmc A variant of mitochondrial protein LOC387715/ARMS2, not HTRA1, is strongly associated with age-related macular degeneration
    Atsuhiro Kanda
    Department of Ophthalmology and Visual Sciences, University of Michigan, Ann Arbor, MI 48105, USA
    Proc Natl Acad Sci U S A 104:16227-32. 2007
    ..We demonstrate, by evaluating 45 tag SNPs spanning HTRA1, PLEKHA1, and predicted gene LOC387715/ARMS2, that rs10490924 SNP alone, or a variant in strong linkage ..
  38. ncbi HTRA1 variant increases risk to neovascular age-related macular degeneration in Chinese population
    Fang Lu
    Human Molecular Biology and Genetics, Sichuan Academy of Medical Sciences and Sichuan Provincial People s Hospital, Sichuan 610072, China
    Vision Res 47:3120-3. 2007
    ..rs11200638 in the promoter of HTRA1 has recently been shown to increases the risk for wet AMD in both Caucasian and Hong Kong Chinese populations...
  39. ncbi LOC387715/HTRA1 and complement factor H variants in patients with age-related macular degeneration seen at the mayo clinic
    Jose S Pulido
    Department of Ophthalmology, Mayo Clinic, Rochester, Minnesota, USA
    Ophthalmic Genet 28:203-7. 2007
    To confirm association of the complement factor H allelic variant (CFH Y402H) and the LOC387715/HTRA1 (LOC387715 A69S) risk alleles with age-related macular degeneration (AMD).
  40. doi Association of HTRA1 polymorphism and bilaterality in advanced age-related macular degeneration
    Haoyu Chen
    State Key Laboratory of Ophthalmology, Zhongshan Ophthalmic Center, Sun Yat Sen University, Guangzhou, China
    Vision Res 48:690-4. 2008
    Single nucleotide polymorphism (SNP), rs11200638, in the promoter of HTRA1 has recently been shown to increase the risk for AMD...
  41. doi Changes in mRNA and protein levels of human HtrA1, HtrA2 and HtrA3 in ovarian cancer
    Joanna Narkiewicz
    Department of Biochemistry, University of Gdansk, Kladki 24, 80 822 Gdansk, Poland
    Clin Biochem 41:561-9. 2008
    Expression of human HtrA1, HtrA2, HtrA3 and TGF-beta1 genes was examined in ovarian tissue specimens including 19 normal ovaries, 20 benign tumors, 7 borderline tumors, 44 cancers and 8 Krukenberg tumors.
  42. doi HTRA1 polymorphism in dry and wet age-related macular degeneration
    Jane Ming Lin
    Department of Ophthalmology, China Medical University Hospital, Taichung, Taiwan
    Retina 28:309-13. 2008
    To investigate HTRA1 polymorphisms in unrelated Taiwan Chinese patients with age-related macular degeneration (AMD) and control subjects without AMD.
  43. pmc HTRA1 variants in exudative age-related macular degeneration and interactions with smoking and CFH
    Pancy O S Tam
    Department of Ophthalmology and Visual Sciences, The Chinese University of Hong Kong, Hong Kong, China
    Invest Ophthalmol Vis Sci 49:2357-65. 2008
    ..had not been successful until recent genome-wide association studies revealed Tyr402His in CFH and rs11200638 in HTRA1 as AMD-related genetic variants...
  44. doi Genotype-phenotype correlations for exudative age-related macular degeneration associated with homozygous HTRA1 and CFH genotypes
    Nicolas Leveziel
    Faculte de Medecine Henri Mondor, Creteil University Eye Clinic, Creteil, France
    Invest Ophthalmol Vis Sci 49:3090-4. 2008
    ..degeneration (AMD) have recently been identified as susceptibility risk factors, including polymorphisms of HTRA1 and CFH genes...
  45. pmc Human HtrA1 in the archived eyes with age-related macular degeneration
    Chi Chao Chan
    Immunopathology Section, Laboratory of Immunology, National Eye Institute, National Institutes of Health, Bethesda, Maryland, USA
    Trans Am Ophthalmol Soc 105:92-7; discussion 97-8. 2007
    b>HtrA1 belongs to the high temperature requirement factor A family of serine proteases, which are involved in protein quality control and cell fate...
  46. doi Variants in the 10q26 gene cluster (LOC387715 and HTRA1) exhibit enhanced risk of age-related macular degeneration along with CFH in Indian patients
    Inderjeet Kaur
    Kallam Anji Reddy Molecular Genetics Laboratory, L V Prasad Eye Institute, Road No 2, Banjara Hills, Hyderabad, India
    Invest Ophthalmol Vis Sci 49:1771-6. 2008
    Single nucleotide polymorphisms (SNPs) in the LOC387715 (rs10490924), HTRA1 (rs11200638), and CFH (rs1061170) genes have been implicated in age-related macular degeneration (AMD)...
  47. doi Intracellular localization of the tumor suppressor HtrA1/Prss11 and its association with HPV16 E6 and E7 proteins
    Gary A Clawson
    Department of Pathology, the Gittlen Cancer Research Foundation, The Pennsylvania State University, Hershey Medical Center, Hershey, Pennsylvania, USA
    J Cell Biochem 105:81-8. 2008
    ..We recently identified the protease as high temperature requirement factor A 1 (HtrA1), also known as Prss11, which is member of an oxidative stress-response family of proteases...
  48. doi Age-related macular degeneration is associated with an unstable ARMS2 (LOC387715) mRNA
    Lars G Fritsche
    Institute of Human Genetics, University of Regensburg, Franz Josef Strauss Allee 11, 93053 Regensburg, Germany
    Nat Genet 40:892-6. 2008
    ..10q26 center over two nearby genes, ARMS2 (age-related maculopathy susceptibility 2, also known as LOC387715) and HTRA1 (high-temperature requirement factor A1), suggesting two equally probable candidates...
  49. doi Association analysis of CFH, C2, BF, and HTRA1 gene polymorphisms in Chinese patients with polypoidal choroidal vasculopathy
    Kelvin Y Lee
    Singapore National Eye Centre, Singapore
    Invest Ophthalmol Vis Sci 49:2613-9. 2008
    ..Variants in the CFH and HTRA1/LOC387715 genes are strongly associated with AMD in Caucasians and Chinese...
  50. doi The serine protease HtrA1 is a novel prognostic factor for human mesothelioma
    Alfonso Baldi
    Department of Biochemistry and Biophysics, Section of Pathology, Second University of Naples, Via L Armanni 5, 80138 Naples, Italy
    Pharmacogenomics 9:1069-77. 2008
    The objective of our study was to analyze the potential prognostic value of the expression of the serine protease HtrA1 and of EGFR in 70 malignant mesotheliomas.
  51. doi Further assessment of the complement component 2 and factor B region associated with age-related macular degeneration
    Gareth J McKay
    Centre for Vision Sciences, Queen s University of Belfast, Belfast, Northern Ireland, United Kingdom
    Invest Ophthalmol Vis Sci 50:533-9. 2009
    ..of the complement system has been implicated as a major cause of genetic risk, in addition to the LOC387715/HTRA1 locus and other environmental influences...
  52. doi Meta-analysis of the association of the HTRA1 polymorphisms with the risk of age-related macular degeneration
    Wen Chen
    Department of Ophthalmology, Union Hospital, Huazhong University of Science and Technology, Wuhan, Hubei 430022, PR China
    Exp Eye Res 89:292-300. 2009
    b>HTRA1 was considered as one of important age-related macular degeneration (AMD) candidate genes...
  53. pmc Prediction model for prevalence and incidence of advanced age-related macular degeneration based on genetic, demographic, and environmental variables
    Johanna M Seddon
    Ophthalmic Epidemiology and Genetics Service, Tufts University School of Medicine and Tufts Medical Center, Boston, Massachusetts 02111, USA
    Invest Ophthalmol Vis Sci 50:2044-53. 2009
    ..The joint effects of genetic, ocular, and environmental variables were evaluated and predictive models for prevalence and incidence of AMD were assessed...
  54. ncbi Genetic variants in three genes and smoking show strong associations with susceptibility to exudative age-related macular degeneration in a Chinese population
    Jie Chu
    Department of Ophthalmology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing, China
    Chin Med J (Engl) 121:2525-33. 2008
    ..polymorphisms in three genes (complement factor H (CFH), complement factor B (BF) and HtrA serine peptidase 1 (HTRA1)) with exudative age-related macular degeneration (AMD) in a Han Chinese population, and to test if the modifiable ..
  55. ncbi Expression of human HtrA1, HtrA2, HtrA3 and TGF-beta1 genes in primary endometrial cancer
    Joanna Narkiewicz
    Department of Biochemistry, University of Gdansk, 80 822 Gdansk, Poland
    Oncol Rep 21:1529-37. 2009
    ..Downregulation of human HtrA1 and HtrA3 genes has been reported in some cancers, including endometrial cancer (EC), suggesting a tumor-..
  56. pmc Serine protease HtrA1 associates with microtubules and inhibits cell migration
    Jeremy Chien
    Experimental Pathology, Mayo Clinic College of Medicine, 200 First Street SW, Rochester, MN 55905, USA
    Mol Cell Biol 29:4177-87. 2009
    b>HtrA1 belongs to a family of serine proteases found in organisms ranging from bacteria to humans...
  57. pmc Identification of a novel HtrA1-susceptible cleavage site in human aggrecan: evidence for the involvement of HtrA1 in aggrecan proteolysis in vivo
    Angela Chamberland
    Department of Tissue Repair, Wyeth Research, Cambridge, Massachusetts 02140, USA
    J Biol Chem 284:27352-9. 2009
    Mass spectrometry-based proteomic analyses performed on cartilage tissue extracts identified the serine protease HtrA1/PRSS11 as a major protein component of human articular cartilage, with elevated levels occurring in association with ..
  58. pmc Comprehensive analysis of complement factor H and LOC387715/ARMS2/HTRA1 variants with respect to phenotype in advanced age-related macular degeneration
    Michael T Andreoli
    Ocular Molecular Genetics Institute, Harvard Medical School, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts 02114, USA
    Am J Ophthalmol 148:869-74. 2009
    To examine the interaction of genotypic variation of 16 single-nucleotide polymorphisms (SNP) in the complement factor H (CFH) and LOC387715/ARMS2/HTRA1 loci with clinical characteristics of age-related macular degeneration (AMD).
  59. doi Analysis of complement factor H Y402H, LOC387715, HTRA1 polymorphisms and ApoE alleles with susceptibility to age-related macular degeneration in Hungarian patients
    Gergely Losonczy
    Department of Ophthalmology, Medical and Health Science Centre, University of Debrecen, Debrecen, Hungary
    Acta Ophthalmol 89:255-62. 2011
    ..of the complement factor H (CFH) gene, Ser69Ala polymorphism at LOC387715, rs11200638 polymorphism of the HTRA1 gene and different apolipoprotein E (ApoE) alleles in Hungarian patients with AMD in order to determine the ..
  60. pmc Genetic and functional dissection of HTRA1 and LOC387715 in age-related macular degeneration
    Zhenglin Yang
    Center for Human Molecular Biology and Genetics, Sichuan Academy of Medical Sciences and Sichuan Provincial People s Hospital, Chengdu, Sichuan, China
    PLoS Genet 6:e1000836. 2010
    ..on 10q26 influences the risk of age-related macular degeneration (AMD) and encompasses two genes, LOC387715 and HTRA1. Recent data have suggested that loss of LOC387715, mediated by an insertion/deletion (in/del) that destabilizes ..
  61. pmc Genetic variants near TIMP3 and high-density lipoprotein-associated loci influence susceptibility to age-related macular degeneration
    Wei Chen
    Center for Statistical Genetics, Biostatistics, University of Michigan, Ann Arbor, MI 48109, USA
    Proc Natl Acad Sci U S A 107:7401-6. 2010
    ..Our studies extend the catalog of AMD associated loci, help identify individuals at high risk of disease, and provide clues about underlying cellular pathways that should eventually lead to new therapies...
  62. pmc Genome-wide association study of advanced age-related macular degeneration identifies a role of the hepatic lipase gene (LIPC)
    Benjamin M Neale
    Center for Human Genetic Research, Massachusetts General Hospital, Boston, MA 02114, USA
    Proc Natl Acad Sci U S A 107:7395-400. 2010
    ..Results implicate different biologic pathways than previously reported and provide new avenues for prevention and treatment of AMD...
  63. doi Downregulation of HtrA1 promotes resistance to anoikis and peritoneal dissemination of ovarian cancer cells
    Xiaoping He
    Department of Laboratory Medicine and Experimental Pathology, Mayo Clinic College of Medicine, Rochester, Minnesota, USA
    Cancer Res 70:3109-18. 2010
    We previously identified serine protease HtrA1 as a downregulated gene in epithelial ovarian cancer (EOC), but the functional consequence of loss of HtrA1 in EOC remains largely unclear...
  64. doi LOC387715/HTRA1 polymorphisms, smoking and combined effects on exudative age-related macular degeneration in a Korean population
    Soo J Lee
    Department of Ophthalmology, Inha University School of Medicine, Incheon, Korea
    Clin Exp Ophthalmol 38:698-704. 2010
    This study was to investigate the association of two single nucleotide polymorphisms (SNPs) in LOC387715 and HTRA1 with exudative age-related macular degeneration (AMD) in a Korean population and the gene-gene and gene-environment ..
  65. doi HtrA proteins as targets in therapy of cancer and other diseases
    Dorota Zurawa-Janicka
    University of Gdansk, Department of Biochemistry, Kladki 24, 80 822 Gdansk, Poland
    Expert Opin Ther Targets 14:665-79. 2010
    The HtrA family proteins are serine proteases that are involved in important physiological processes, including maintenance of mitochondrial homeostasis, apoptosis and cell signaling...
  66. doi [Association study on single nucleotide polymorphisms in HTRA1 gene and rheumatoid arthritis]
    Rui jun Luo
    Department of Immunology, West China School of Preclinical and Forensic Medicine, Sichuan University, Chengdu, Sichuan, 610041 PR China
    Zhonghua Yi Xue Yi Chuan Xue Za Zhi 27:305-9. 2010
    To study the association between the single nucleotide polymorphisms (SNPs) in the high-temperature requirement A-1 (HTRA1) gene and rheumatoid arthritis (RA) in Chinese Han population.
  67. pmc Genome-wide association identifies SKIV2L and MYRIP as protective factors for age-related macular degeneration
    L J Kopplin
    Department of Genetics, Case Western Reserve University, Cleveland, OH 44106, USA
    Genes Immun 11:609-21. 2010
    ..From these efforts, we report the identification of two novel protective factors for AMD and confirm the previously known associations at CFH, ARMS2 and C3...
  68. ncbi Serine protease HtrA1 expression in human hepatocellular carcinoma
    Feng Zhu
    Department of Hepatobiliary Surgery, Third Affiliated Hospital, Soochow University, Changzhou 210003, China
    Hepatobiliary Pancreat Dis Int 9:508-12. 2010
    b>HtrA1, a serine protease, is down-regulated in various human solid tumors. Overexpression of HtrA1 in human cancer cells inhibits cell growth and proliferation in vitro and in vivo, suggesting its possible role as a tumor suppressor.
  69. pmc LOC387715/HTRA1 gene polymorphisms and susceptibility to age-related macular degeneration: A HuGE review and meta-analysis
    Yu Tong
    Laboratory of Early Development and Injuries, Center for Research of Child Development and Disease, West China Second University Hospital, Chengdu, China
    Mol Vis 16:1958-81. 2010
    To examine the association of age-related macular degeneration (AMD) with HtrA serine peptidase 1 (HTRA1) gene rs11200638 G→A polymorphism and LOC387715/ ARMS2 gene rs10490924 G→T polymorphisms, and to evaluate the magnitude of the ..
  70. pmc ARMS2/HTRA1 locus can confer differential susceptibility to the advanced subtypes of age-related macular degeneration
    Lucia Sobrin
    Department of Ophthalmology, Harvard Medical School, Massachusetts Eye and Ear Infirmary, Boston, Massachusetts, USA
    Am J Ophthalmol 151:345-52.e3. 2011
    ..To determine if genetic variants that have been associated with age-related macular degeneration (AMD) have a differential effect on the risk of choroidal neovascularization (CNV) and geographic atrophy...
  71. doi Haplotype analysis of the ARMS2/HTRA1 region in Japanese patients with typical neovascular age-related macular degeneration or polypoidal choroidal vasculopathy
    Norimoto Gotoh
    Department of Ophthalmology and Visual Sciences, Kyoto University Graduate School of Medicine, Kyoto, 606 8507, Japan
    Jpn J Ophthalmol 54:609-14. 2010
    To compare the genomic contribution of the ARMS2/HTRA1 region of chromosome 10q26 to typical neovascular age-related macular degeneration (nAMD) (also known as typical exudative AMD) and to polypoidal choroidal vasculopathy (PCV) METHODS:..
  72. doi Cerebral small-vessel disease protein HTRA1 controls the amount of TGF-β1 via cleavage of proTGF-β1
    Atsushi Shiga
    Department of Neurology, Brain Research Institute, Niigata University, Niigata 951 8122, Japan
    Hum Mol Genet 20:1800-10. 2011
    ..disease, cerebral autosomal recessive arteriopathy with subcortical infarcts and leukoencephalopathy (CARASIL)...
  73. pmc Common variants near FRK/COL10A1 and VEGFA are associated with advanced age-related macular degeneration
    Yi Yu
    Ophthalmic Epidemiology and Genetics Service, New England Eye Center, Tufts Medical Center, Tufts University School of Medicine, 800 WashingtonStreet, No 450, Boston, MA 02111, USA
    Hum Mol Genet 20:3699-709. 2011
    ..15; P = 8.7 × 10(-9)). In addition to the two novel loci, 10 previously reported loci in ARMS2/HTRA1 (rs10490924), CFH (rs1061170, and rs1410996), CFB (rs641153), C3 (rs2230199), C2 (rs9332739), CFI (rs10033900), ..
  74. pmc Increased expression of multifunctional serine protease, HTRA1, in retinal pigment epithelium induces polypoidal choroidal vasculopathy in mice
    Alex Jones
    Department of Ophthalmology and Visual Sciences, University of Utah School of Medicine, Salt Lake City, UT 84132, USA
    Proc Natl Acad Sci U S A 108:14578-83. 2011
    ..Genome-wide association studies have linked a multifunctional serine protease, HTRA1, to AMD. However, the precise role of HTRA1 in AMD remains elusive...
  75. doi Association of ARMS2/HTRA1 variants with polypoidal choroidal vasculopathy phenotype in a Korean population
    Dong Ho Park
    Department of Ophthalmology, School of Medicine, Kyungpook National University, 50 Samduk dong 2 ga, Jung Gu, Daegu 700 721, South Korea
    Jpn J Ophthalmol 56:60-7. 2012
    To investigate whether ARMS2 (rs10490924)/HTRA1 (rs11200638) variants are associated with polypoidal choroidal vasculopathy (PCV) in a Korean population and with various PCV phenotypes.
  76. pmc Composition and proteolytic processing of corneal deposits associated with mutations in the TGFBI gene
    Henrik Karring
    Institute of Chemical Engineering, Biotechnology and Environmental Technology, Faculty of Engineering, University of Southern Denmark, Niels Bohrs Alle 1, DK 5230 Odense M, Denmark
    Exp Eye Res 96:163-70. 2012
    ..These cleavage sites were consistent with the ligand binding and proteolytic activity of HtrA1 suggesting that it plays a role in the proteolytic processing of the amyloidogenic FAS1-4 domain...
  77. doi Phenotype and genotype characteristics of age-related macular degeneration in a Japanese population
    Keisuke Mori
    Department of Ophthalmology, Saitama Medical University, Iruma, Saitama, Japan
    Ophthalmology 117:928-38. 2010
    ..To describe phenotype and genotype characteristics of age-related macular degeneration (AMD) in Japanese patients...
  78. doi Expression and localization of the serine proteases high-temperature requirement factor A1, serine protease 23, and serine protease 35 in the mouse ovary
    Patrik Wahlberg
    Department of Medical Biochemistry and Biophysics, Umea University, SE 901 87 Umea, Sweden
    Endocrinology 149:5070-7. 2008
    ..serine proteases that were relatively highly expressed during ovulation: high-temperature requirement factor A1 (HtrA1), which was not regulated much during ovulation; serine protease 23 (PRSS23), which was down-regulated by ..
  79. pmc Two distinct loci affecting conversion to mucoidy in Pseudomonas aeruginosa in cystic fibrosis encode homologs of the serine protease HtrA
    J C Boucher
    Department of Microbiology, University of Texas Health Science Center at San Antonio 78284 7758, USA
    J Bacteriol 178:511-23. 1996
    ..The predicted primary structure of AlgW displayed similarity to HtrA (DegP), a serine protease involved in proteolysis of abnormal proteins and required for resistance to oxidative and ..
  80. pmc Identification of novel substrates for the serine protease HTRA1 in the human RPE secretome
    Eunkyung An
    Center for Genetic Medicine, Children s National Medical Center, Washington, DC, USA
    Invest Ophthalmol Vis Sci 51:3379-86. 2010
    PURPOSE. To define the role of the serine protease HTRA1 in age-related macular degeneration (AMD) by examining its expression level and identifying its potential substrates in the context of primary RPE cell extracellular milieu...
  81. ncbi A novel serine protease of the mammalian HtrA family is up-regulated in mouse uterus coinciding with placentation
    Gui Ying Nie
    Prince Henry s Institute of Medical Research, P O Box 5152, 246 Clayton Road, Clayton, Victoria 3168, Australia
    Mol Hum Reprod 9:279-90. 2003
    ..PRSP is structurally similar to mammalian HtrA1 (56% amino acid similarity)...
  82. pmc An update on the genetics of age-related macular degeneration
    Hendrik P N Scholl
    Department of Ophthalmology, University of Bonn, Bonn, Germany
    Mol Vis 13:196-205. 2007
    ..These findings imply that the innate immune system may play a significant role in AMD pathogenesis. The LOC387715/HTRA1 locus within 10q26 has been identified as a second major locus contributing to AMD pathogenesis...
  83. ncbi Current immunizations for travel
    Beth D Kirkpatrick
    University of Vermont College of Medicine, MCHV Campus, 303 Burgess Building, 111 Colchester Avenue, Burlington, VT 05401, USA
    Curr Opin Infect Dis 16:369-74. 2003
    ..Some of these diseases are preventable, and vaccination remains a cornerstone of travel medicine. Vaccines that are important for international travel are reviewed, in a succinct update based on the most recent literature...
  84. pmc Prior immunity to homologous and heterologous Salmonella serotypes suppresses local and systemic anti-fragment C antibody responses and protection from tetanus toxin in mice immunized with Salmonella strains expressing fragment C
    M Roberts
    Department of Veterinary Pathology, Glasgow University Veterinary School, Glasgow G61 1QH, United Kingdom
    Infect Immun 67:3810-5. 1999
    ..only with respect to the promoter controlling FrgC expression, the nirB promoter in the case of BRD847 and the htrA promoter in the case of BRD937. Mice were preimmunized orally with S. typhimurium BRD509, S...
  85. doi Genetic deficiency of complement factor H in a patient with age-related macular degeneration and membranoproliferative glomerulonephritis
    Tamara Montes
    Centro de Investigaciones Biológicas and Centro de Investigación Biomédica en Enfermedades Raras, Ramiro de Maeztu 9, Madrid, Spain
    Mol Immunol 45:2897-904. 2008
    ..Genetic analyses of the CFH, CFB, C3, CFHR1-CFHR3 and LOC387715/HTRA1 genes revealed that the patient was heterozygote for a novel missense mutation in exon 9 of CFH (c...
  86. ncbi Degradation by proteases Lon, Clp and HtrA, of Escherichia coli proteins aggregated in vivo by heat shock; HtrA protease action in vivo and in vitro
    E Laskowska
    Department of Biochemistry, University of Gdansk, Kladki, Poland
    Mol Microbiol 22:555-71. 1996
    ..Comparison of the rise and decay of the S fraction in mutants defective for heat-shock proteases Lon (La), Clp, HtrA (DegP, Do) and in wild-type strains made studies of proteolysis and the function of the heat-shock response ..
  87. pmc Multifactor effects and evidence of potential interaction between complement factor H Y402H and LOC387715 A69S in age-related macular degeneration
    Sanna P Seitsonen
    Department of Ophthalmology, University of Helsinki, Helsinki, Finland
    PLoS ONE 3:e3833. 2008
    Variants in the complement cascade genes and the LOC387715/HTRA1, have been widely reported to associate with age-related macular degeneration (AMD), the most common cause of visual impairment in industrialized countries.
  88. pmc The peptidyl-prolyl isomerase motif is lacking in PmpA, the PrsA-like protein involved in the secretion machinery of Lactococcus lactis
    Sophie Drouault
    Unité d Ecologie et de Physiologie du Système Digestif Unité de Génétique Microbienne, Institut National de la Recherche Agronomique, 78352 Jouy en Josas Cedex, France
    Appl Environ Microbiol 68:3932-42. 2002
    ..PmpA either triggers the folding of the secreted lipase or activates its degradation by the cell surface protease HtrA. Unlike the case for B...
  89. pmc Identification of an immunoreactive Brucella abortus HtrA stress response protein homolog
    R M Roop
    Department of Microbiology and Immunology, Louisiana State University Medical Center, Shreveport 71130 3932
    Infect Immun 62:1000-7. 1994
    ..coli and Salmonella typhimurium HtrA stress response proteins...
  90. ncbi Detection of a novel spotted fever group rickettsia in Amblyomma parvum ticks (Acari: Ixodidae) from Argentina
    Richard C Pacheco
    Departamento de Medicina Veterinaria Preventiva e Saude Animal, Faculdade de Medicina Veterinaria e Zootecnia, Universidade de Sao Paulo, Av Prof Dr Orlando Marques de Paiva 87, Cidade Universitaria, Sao Paulo, SP 05508 270, Brazil
    Exp Appl Acarol 43:63-71. 2007
    ..Three of these ticks were tested in another battery of PCR targeting fragments of the rickettsial genes gltA, htrA, and ompA...
  91. pmc Role of HTRA1, a serine protease, in the progression of articular cartilage degeneration
    Ilona Polur
    Department of Developmental Biology, Harvard School of Dental Medicine, Boston, MA 02115, USA
    Histol Histopathol 25:599-608. 2010
    This study is to investigate the possible role of high temperature requirement A 1 (HtrA1) in the articular cartilage degeneration...
  92. pmc Characterization of spotted fever group rickettsiae in flea and tick specimens from northern Peru
    Patrick J Blair
    U S Naval Medical Research Center Detachment, Lima, Peru
    J Clin Microbiol 42:4961-7. 2004
    ..the etiologic agents from these samples was determined after partial sequencing of the 17-kDa common antigen gene (htrA) as well as pairwise nucleotide sequence homology with one or more of the following genes: gltA, ompA, and ompB...
  93. pmc Isolation and identification of Rickettsia massiliae from Rhipicephalus sanguineus ticks collected in Arizona
    Marina E Eremeeva
    Viral and Rickettsial Zoonoses Branch, National Center for Infectious Diseases, Centers for Disease Control and Prevention, Atlanta, GA 30333, USA
    Appl Environ Microbiol 72:5569-77. 2006
    ..With a nested PCR assay which detects a fragment of the Rickettsia genus-specific 17-kDa antigen gene (htrA), five ticks (25%) were found to contain rickettsial DNA...
  94. doi The involvement of complement factor B and complement component C2 in an Indian cohort with age-related macular degeneration
    Inderjeet Kaur
    Hyderabad Eye Research Foundation, Champalimaud Translational Centre, Brien Holden Eye Research Centre, L V Prasad Eye Institute, Hyderabad, India
    Invest Ophthalmol Vis Sci 51:59-63. 2010
    ..In continuation of the analysis of CFH and LOC387715/HTRA1, this study was conducted to gain understanding of the role of CFB and C2 in an Indian AMD cohort.
  95. pmc The HtrA protease of Campylobacter jejuni is required for heat and oxygen tolerance and for optimal interaction with human epithelial cells
    Lone Brøndsted
    Department of Veterinary Pathobiology, The Royal Veterinary and Agricultural University, Stigbøjlen 4, DK 1870 Frederiksberg C, Denmark
    Appl Environ Microbiol 71:3205-12. 2005
    ..We have investigated the importance of a homologue of the periplasmic HtrA protease in C. jejuni stress tolerance. A C...
  96. pmc Diagnosis of cat scratch disease with detection of Bartonella henselae by PCR: a study of patients with lymph node enlargement
    Yves Hansmann
    Service des Maladies Infectieuses et Tropicales, Hopitaux Universitaires de Strasbourg, 1, Place de l Hopital, 67091 Strasbourg Cedex, France
    J Clin Microbiol 43:3800-6. 2005
    ..henselae DNA (htrA gene) in the Bacteriology Laboratory of the Hôpitaux Universitaires de Strasbourg...
  97. ncbi Relapsing fever spirochaetes produce a serine protease that provides resistance to oxidative stress and killing by neutrophils
    Cyril Guyard
    Laboratory of Human Bacterial Pathogenesis, Rocky Mountain Laboratories, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Hamilton, MT 59840, USA
    Mol Microbiol 60:710-22. 2006
    ..The predicted amino acid sequence of bhpA was homologous with the HtrA serine proteases, which are involved with stress responses and virulence in other bacteria. B...
  98. pmc Salmonella enterica serovar Typhi Ty21a expressing human papillomavirus type 16 L1 as a potential live vaccine against cervical cancer and typhoid fever
    Dominique Fraillery
    Institute of Microbiology, Centre Hospitalier Universitaire Vaudois and University of Lausanne, CH 1011 Lausanne, Switzerland
    Clin Vaccine Immunol 14:1285-95. 2007
    ..Ty21a, the actual licensed typhoid vaccine, and two highly immunogenic typhoid vaccine candidates, Ty800 and CVD908-htrA. In an intranasal mouse model of Salmonella serovar Typhi infection, Ty21a kanL1S was unique in inducing HPV16-..
  99. pmc New genes of Xanthomonas citri subsp. citri involved in pathogenesis and adaptation revealed by a transposon-based mutant library
    Marcelo L Laia
    Departamento de Tecnologia, Universidade Estadual Paulista, UNESP, Campus de Jaboticabal, Jaboticabal, SP, Brazil
    BMC Microbiol 9:12. 2009
    ..Considering the importance of the disease worldwide, investigation is needed to accurately detect which genes are related to the pathogen-host adaptation process and which are associated with pathogenesis...
  100. pmc Cyclic di-GMP signaling regulates invasion by Ehrlichia chaffeensis of human monocytes
    Yumi Kumagai
    Department of Veterinary Biosciences, The Ohio State University, Columbus, OH 43210, USA
    J Bacteriol 192:4122-33. 2010
    ..Indeed, the serine protease HtrA was detected on the surface of E. chaffeensis, and TRP120 was degraded by treatment of E...
  101. pmc Optimization of plasmid maintenance in the attenuated live vector vaccine strain Salmonella typhi CVD 908-htrA
    J E Galen
    Center for Vaccine Development, Division of Geographic Medicine, Department of Medicine, University of Maryland School of Medicine, Baltimore, Maryland 21201, USA
    Infect Immun 67:6424-33. 1999
    ..expression plasmids encoding foreign antigens in a Salmonella typhi live-vector vaccine strain such as CVD 908-htrA. We have enhanced the maintenance of expression plasmids at two independent levels...

Research Grants34

  1. Building a Better AMD Mouse
    Caroline J Zeiss; Fiscal Year: 2010
    ..The recent discovery of a polymorphic variant of HTRA Serine Peptidase 1 (HTRA1) as a risk factor for wet AMD implicates an entirely different mechanism (abnormal matrix metabolism and TGF-2 ..
  2. Characterizing Exportal by a Polymyxin B Resistance-Based Mutagenic Approach
    Luis Alberto Vega; Fiscal Year: 2010
    ..an anionic membrane microdomain enriched in secretory (Sec) translocons and the membrane anchored serine protease HtrA. The role of the ExPortal as a system coordinating protein secretion and maturation in S...
  3. Functional analysis of AMD-associated HTRA1 promoter polymorphism
    Noriko Esumi; Fiscal Year: 2010
    The objective of this proposal is to define the functional role of the HTRA1 promoter polymorphism that was recently identified as a variant associated with susceptibility to age-related macular degeneration (AMD), and to begin to ..
  4. Genetic Epidemiology of Age-Related Macular Degeneration
    Debra A Schaumberg; Fiscal Year: 2011
    ..for AMD in relation to common variants within a group of strong candidate genes including complement factor H, HTRA1/LOC387715, and others (candidates identified based on position, function, expression, etc...
  5. Regulation of Serine Protease HtrA1 and Chemoresponse
    Viji Shridhar; Fiscal Year: 2012
    ..Our studies have shown that altered expression of the serine protease HtrA1 modulates chemotherapy induced cytotoxicity...
  6. Robert T Sauer; Fiscal Year: 2016
    DESCRIPTION (provided by applicant): Intracellular proteases of the AAA+ and HtrA families remove toxic proteins from cells and participate in cellular processes that promote health and prevent disease...
  7. Genetics and Functional Studies of Age-Related Macular Degeneration
    Kang Zhang; Fiscal Year: 2012
    ..We and others have demonstrated that HTRA1 may play a major role in genetic susceptibilty to AMD...
  8. Validation and development of specific small molecule inhibitors of HTRA1 for tre
    Shuyuan Yao; Fiscal Year: 2010
    ..CalCyte's scientific co-founder, Kang Zhang, reported that polymorphisms in the promoter of the gene encoding HTRA1 plays a major role in genetic susceptibility to AMD...
  9. SIBLING STUDY OF AGE-RELATED MACULAR DEGENERATION
    Margaret M DeAngelis; Fiscal Year: 2010
    ..has established alleles as well as haplotypes on chromosomes 1 and 10, particularly in CFH and LOC387715/ARMS2/HTRA1, as having large influences on AMD risk in populations of various ethnicities...
  10. Ashok K Chopra; Fiscal Year: 2015
    ..mutant was unable to survive within macrophages, which was linked to the down-regulation of a stress response gene (htrA) in this mutant. We inferred from these data that other stress-associated genes (e.g...
  11. SUZANNE RACHEL DAWID; Fiscal Year: 2016
    ..In Aim 2 we will determine the role of the regulatory proteins CiaRH and HtrA in controlling the cross talk between the blp and com systems...
  12. Margaret A Pericak-Vance; Fiscal Year: 2014
    ..have identified and confirmed variations in multiple genes that strongly affect risk to AMD, including CFH, HTRA1/ARMS2, C2/CFB, and C3 explaining a significant portion of the genetic risk for AMD...
  13. William K Scott; Fiscal Year: 2015
    ..our own, have identified and confirmed variations in multiple genes that affect risk to AMD, including CFH, HTRA1/ARMS2, C2/CFB, and C3 (DeAngelis et al. 2007;Edwards et al. 2005;Haines et al. 2005;Jakobsdottir et al...
  14. Complex Mouse Models of Age-related Macular Degeneration
    Caroline J Zeiss; Fiscal Year: 2013
    ..Therefore this resubmission focuses whether polymorphisms in two recently discovered genes (CFH and HTRA1) that are associated with AMD in humans can induce the disease in mice...
  15. Anti-HTRA1 Therapy For AMD
    ALAN L MUELLER; Fiscal Year: 2010
    DESCRIPTION (provided by applicant): In our Phase I application, we proposed that blocking HTRA1 with antibodies might be an effective strategy for treating age related macular degeneration...
  16. Michael G Caparon; Fiscal Year: 2014
    ..microdomain that accumulates a high concentration of Sec translocons and accessory biogenesis factors including HtrA and Sortase...
  17. Streptococcus pneumoniae genetic competence and pathogenesis
    Michael E Sebert; Fiscal Year: 2011
    ..This aim focuses on the surface protease HtrA that we have shown to repress the development of competence...
  18. ENGINEERING THERAPEUTIC PROTEASES
    Robert F Balint; Fiscal Year: 2012
    ..will incorporate full-length human TNF1 for selections from a mutagenic library based on the proteolytic domain of HtrA1, a human chymotrypsin family protease with unique properties for the engineering of target-specific activities...
  19. Cross-Protective Vaccines Against Emerging Infectious Agents
    MICHAEL MAHAN; Fiscal Year: 2007
    ..biosynthetic pathways (aroA aroD), regulatory genes (cya crp and phoP phoQ), and genes encoding stress proteins (htrA) and combinations of these mutations...
  20. DEGP PROTEINASE INHIBITORS: NOVEL ANTI-INFECTIVES
    C Jones; Fiscal Year: 2000
    The DegP (HtrA) protease is essential for virulence in several Gram- negative pathogens: S.typhimurium, B. abortus, Y. enterocolitica, E. coli and P. aeruginosa. This important virulence factor was recently identified in S. pyogenes and S...
  21. Molecular Mechanisms of Pneumococcal Colonization
    Michael Sebert; Fiscal Year: 2006
    ..not all, of this failure to colonize effectively can be attributed to downregulation of a putative serine protease, HtrA. The hypothesis to be tested in the proposed research is that a set of genes is regulated by the CiaRH system that ..
  22. DEGP PROTEINASE INHIBITORS: NOVEL ANTI-INFECTIVES
    Dennis Hruby; Fiscal Year: 2003
    The DegP (HtrA) protease is essential for virulence in several Gram-negative pathogens: S. typhimurium, B. melitensis, Y. enterocolitica and P. aeruginosa...
  23. APP/PROTEASE INTERACTION EFFECT ON APP PROCESSING
    Suzanne Guenette; Fiscal Year: 1999
    ..This protease is a member of the htrA class of serine protease which is highly conserved throughout evolution...
  24. Targeting HTRA 1 for the Treatment of Age Related Macular Degeneration
    Sutip Navankasattusas; Fiscal Year: 2008
    ..co-founder, Kang Zhang, recently reported in SCIENCE that a polymorphism in the promoter of the gene encoding HTRA1 plays a major role in genetic susceptibility to AMD...
  25. Biological Factors for Age-Related Macular Degeneration
    Johanna Seddon; Fiscal Year: 2004
    ..abstract_text> ..
  26. Immune Responses to Biodefense Vaccines Early in Life
    Marcela F Pasetti; Fiscal Year: 2010
    ..It will also provide knowledge to better understand the mechanisms mediating neonatal-infant immunity to develop more effectivevaccines to prevent diseases early in life. ..
  27. Molecular Genetics of X-L Cone-Rod Dystrophy
    Michael Gorin; Fiscal Year: 2003
    ..This study will help to resolve issues of allelic and genetic heterogeneity for X-linked retinal degenerations and will further our understanding of the biology of degenerative eye diseases. ..
  28. MAPPING AND CLONING OF NON-HLA GENES FOR CELIAC DISEASE
    Susan Neuhausen; Fiscal Year: 2005
    ..Furthermore, more detailed knowledge about genes causing CD could lead to therapeutics to reduce the diet restrictions and morbidity of celiac disease. ..
  29. Sixth International Conference on Legionella
    Nicholas Cianciotto; Fiscal Year: 2005
    ..This unique gathering of microbiologists, physicians, public health officials, and engineers is the definitive meeting for those concerned with Legionella and its associated diseases. ..
  30. The IGF Signaling Pathway and Breast Cancer Risk
    Susan L Neuhausen; Fiscal Year: 2010
    ..Currently, chemotherapies are being directed to the IGF pathway and the results of this study could provide further targets, as well as assist in identifying the group of women who could particularly benefit from these new drugs. ..
  31. An RNA Sensor for Detection of Circulating Tumor Cells
    Gary Clawson; Fiscal Year: 2008
    ..abstract_text> ..
  32. Genetic Epidemiology of Breast Cancer: BRCA1 and BRCA2
    Susan Neuhausen; Fiscal Year: 2007
    ..This information can be used to assist women and their physicians in individual risk assessment, as well as to target women for specific prevention or treatment strategies based on their genetic risk factors. ..
  33. Genetics of Age-Related Macular Degeneration
    Michael Klein; Fiscal Year: 2007
    ..abstract_text> ..
  34. Expression of Cell Surface Proteins in Streptococcus mutans
    Indranil Biswas; Fiscal Year: 2007
    ..We found that a functional HtrA (a serine protease needed for processing and maturation of proteins) is required for biofilm formation in S. mutans...