HTRA1

Summary

Gene Symbol: HTRA1
Description: HtrA serine peptidase 1
Alias: ARMD7, CADASIL2, CARASIL, HtrA, L56, ORF480, PRSS11, serine protease HTRA1, IGFBP5-protease, high-temperature requirement A serine peptidase 1, protease, serine, 11 (IGF binding)
Species: human
Products:     HTRA1

Top Publications

  1. DeAngelis M, Ji F, Adams S, Morrison M, Harring A, Sweeney M, et al. Alleles in the HtrA serine peptidase 1 gene alter the risk of neovascular age-related macular degeneration. Ophthalmology. 2008;115:1209-1215.e7 pubmed publisher
    ..domain-containing protein gene (PLEKHA1), hypothetical LOC387715/ARMS2 gene, and HtrA serine peptidase 1 gene (HTRA1) located on the long arm of chromosome 10 (10q26 region) confer risk for neovascular age-related macular ..
  2. Kanda A, Chen W, Othman M, Branham K, Brooks M, Khanna R, et al. A variant of mitochondrial protein LOC387715/ARMS2, not HTRA1, is strongly associated with age-related macular degeneration. Proc Natl Acad Sci U S A. 2007;104:16227-32 pubmed
    ..We demonstrate, by evaluating 45 tag SNPs spanning HTRA1, PLEKHA1, and predicted gene LOC387715/ARMS2, that rs10490924 SNP alone, or a variant in strong linkage ..
  3. Chien J, Aletti G, Baldi A, Catalano V, Muretto P, Keeney G, et al. Serine protease HtrA1 modulates chemotherapy-induced cytotoxicity. J Clin Invest. 2006;116:1994-2004 pubmed
    ..These findings uncover what we believe to be a novel pathway by which serine protease HtrA1 mediates paclitaxel- and cisplatin-induced cytotoxicity and suggest that loss of HtrA1 in ovarian and ..
  4. Tong Y, Liao J, Zhang Y, Zhou J, Zhang H, Mao M. LOC387715/HTRA1 gene polymorphisms and susceptibility to age-related macular degeneration: A HuGE review and meta-analysis. Mol Vis. 2010;16:1958-81 pubmed
    To examine the association of age-related macular degeneration (AMD) with HtrA serine peptidase 1 (HTRA1) gene rs11200638 G?A polymorphism and LOC387715/ ARMS2 gene rs10490924 G?T polymorphisms, and to evaluate the magnitude of the gene ..
  5. Lee S, Kim N, Chin H. LOC387715/HTRA1 polymorphisms, smoking and combined effects on exudative age-related macular degeneration in a Korean population. Clin Exp Ophthalmol. 2010;38:698-704 pubmed publisher
    This study was to investigate the association of two single nucleotide polymorphisms (SNPs) in LOC387715 and HTRA1 with exudative age-related macular degeneration (AMD) in a Korean population and the gene-gene and gene-environment ..
  6. Lorenzi T, Marzioni D, Giannubilo S, Quaranta A, Crescimanno C, De Luca A, et al. Expression patterns of two serine protease HtrA1 forms in human placentas complicated by preeclampsia with and without intrauterine growth restriction. Placenta. 2009;30:35-40 pubmed publisher
    ..b>HtrA1, a member of the family of HtrA proteins, is a secreted multidomain protein with serine protease activity...
  7. Pulido J, Peterson L, Mutapcic L, Bryant S, Highsmith W. LOC387715/HTRA1 and complement factor H variants in patients with age-related macular degeneration seen at the mayo clinic. Ophthalmic Genet. 2007;28:203-7 pubmed
    To confirm association of the complement factor H allelic variant (CFH Y402H) and the LOC387715/HTRA1 (LOC387715 A69S) risk alleles with age-related macular degeneration (AMD)...
  8. Seddon J, Gensler G, Rosner B. C-reactive protein and CFH, ARMS2/HTRA1 gene variants are independently associated with risk of macular degeneration. Ophthalmology. 2010;117:1560-6 pubmed publisher
    Genetic variants CFH and ARMS2/HTRA1 gene regions as well as high-sensitivity C-reactive protein (CRP) levels are related to age-related macular degeneration (AMD)...
  9. Neale B, Fagerness J, Reynolds R, Sobrin L, Parker M, Raychaudhuri S, et al. Genome-wide association study of advanced age-related macular degeneration identifies a role of the hepatic lipase gene (LIPC). Proc Natl Acad Sci U S A. 2010;107:7395-400 pubmed publisher
    ..Results implicate different biologic pathways than previously reported and provide new avenues for prevention and treatment of AMD. ..

More Information

Publications77

  1. Gotoh N, Yamashiro K, Nakanishi H, Saito M, Iida T, Yoshimura N. Haplotype analysis of the ARMS2/HTRA1 region in Japanese patients with typical neovascular age-related macular degeneration or polypoidal choroidal vasculopathy. Jpn J Ophthalmol. 2010;54:609-14 pubmed publisher
    To compare the genomic contribution of the ARMS2/HTRA1 region of chromosome 10q26 to typical neovascular age-related macular degeneration (nAMD) (also known as typical exudative AMD) and to polypoidal choroidal vasculopathy (PCV) METHODS:..
  2. Oka C, Tsujimoto R, Kajikawa M, Koshiba Takeuchi K, Ina J, Yano M, et al. HtrA1 serine protease inhibits signaling mediated by Tgfbeta family proteins. Development. 2004;131:1041-53 pubmed
    b>HtrA1, a member of the mammalian HtrA serine protease family, has a highly conserved protease domain followed by a PDZ domain...
  3. Cameron D, Yang Z, Gibbs D, Chen H, Kaminoh Y, Jorgensen A, et al. HTRA1 variant confers similar risks to geographic atrophy and neovascular age-related macular degeneration. Cell Cycle. 2007;6:1122-5 pubmed
    ..A single nucleotide polymorphism, rs11200638, in the promoter of HTRA1 has been shown to increases the risk for wet AMD...
  4. Yoshida T, Dewan A, Zhang H, Sakamoto R, Okamoto H, Minami M, et al. HTRA1 promoter polymorphism predisposes Japanese to age-related macular degeneration. Mol Vis. 2007;13:545-8 pubmed
    ..6 kb and 512 bp upstream of the HTRA1 gene, respectively, using temperature gradient capillary electrophoresis (TGCE) and direct sequencing...
  5. Marzioni D, Quaranta A, Lorenzi T, Morroni M, Crescimanno C, De Nictolis M, et al. Expression pattern alterations of the serine protease HtrA1 in normal human placental tissues and in gestational trophoblastic diseases. Histol Histopathol. 2009;24:1213-22 pubmed publisher
    b>HtrA1 is a secreted protein which behaves as a molecular chaperone at low temperatures and as a serine protease at high temperatures...
  6. Zumbrunn J, Trueb B. Primary structure of a putative serine protease specific for IGF-binding proteins. FEBS Lett. 1996;398:187-92 pubmed
    ..This protein has a molecular mass of 51 kDa and is highly related to the HtrA family of serine proteases from bacteria...
  7. Karring H, Runager K, Thøgersen I, Klintworth G, Højrup P, Enghild J. Composition and proteolytic processing of corneal deposits associated with mutations in the TGFBI gene. Exp Eye Res. 2012;96:163-70 pubmed publisher
    ..These cleavage sites were consistent with the ligand binding and proteolytic activity of HtrA1 suggesting that it plays a role in the proteolytic processing of the amyloidogenic FAS1-4 domain...
  8. Seddon J, Reynolds R, Maller J, Fagerness J, Daly M, Rosner B. Prediction model for prevalence and incidence of advanced age-related macular degeneration based on genetic, demographic, and environmental variables. Invest Ophthalmol Vis Sci. 2009;50:2044-53 pubmed publisher
    ..831 for progression to advanced AMD. Factors reflective of nature and nurture are independently related to prevalence and incidence of advanced AMD, with excellent predictive power. ..
  9. Hughes A, Orr N, Patterson C, Esfandiary H, Hogg R, McConnell V, et al. Neovascular age-related macular degeneration risk based on CFH, LOC387715/HTRA1, and smoking. PLoS Med. 2007;4:e355 pubmed
    ..Polymorphisms in the complement factor H (CFH) gene, LOC387715, and the HTRA1 promoter are strongly associated with AMD. Smoking also contributes to the etiology...
  10. McKay G, Silvestri G, Patterson C, Hogg R, Chakravarthy U, Hughes A. Further assessment of the complement component 2 and factor B region associated with age-related macular degeneration. Invest Ophthalmol Vis Sci. 2009;50:533-9 pubmed publisher
    ..of the complement system has been implicated as a major cause of genetic risk, in addition to the LOC387715/HTRA1 locus and other environmental influences...
  11. Chu J, Zhou C, Lu N, Zhang X, Dong F. Genetic variants in three genes and smoking show strong associations with susceptibility to exudative age-related macular degeneration in a Chinese population. Chin Med J (Engl). 2008;121:2525-33 pubmed
    ..polymorphisms in three genes (complement factor H (CFH), complement factor B (BF) and HtrA serine peptidase 1 (HTRA1)) with exudative age-related macular degeneration (AMD) in a Han Chinese population, and to test if the modifiable ..
  12. Lin J, Wan L, Tsai Y, Lin H, Tsai Y, Lee C, et al. HTRA1 polymorphism in dry and wet age-related macular degeneration. Retina. 2008;28:309-13 pubmed publisher
    To investigate HTRA1 polymorphisms in unrelated Taiwan Chinese patients with age-related macular degeneration (AMD) and control subjects without AMD...
  13. Sobrin L, Reynolds R, Yu Y, Fagerness J, Leveziel N, Bernstein P, et al. ARMS2/HTRA1 locus can confer differential susceptibility to the advanced subtypes of age-related macular degeneration. Am J Ophthalmol. 2011;151:345-52.e3 pubmed publisher
    ..The frequency of the T allele of ARMS2/HTRA1 rs10490924 was significantly higher in participants with CNV than in those with geographic atrophy (OR, 1...
  14. Jones A, Kumar S, Zhang N, Tong Z, Yang J, WATT C, et al. Increased expression of multifunctional serine protease, HTRA1, in retinal pigment epithelium induces polypoidal choroidal vasculopathy in mice. Proc Natl Acad Sci U S A. 2011;108:14578-83 pubmed publisher
    ..Genome-wide association studies have linked a multifunctional serine protease, HTRA1, to AMD. However, the precise role of HTRA1 in AMD remains elusive...
  15. Hu S, Carozza M, Klein M, Nantermet P, Luk D, Crowl R. Human HtrA, an evolutionarily conserved serine protease identified as a differentially expressed gene product in osteoarthritic cartilage. J Biol Chem. 1998;273:34406-12 pubmed
    The human homologue of the Escherichia coli htrA gene product was identified by the differential display analysis of transcripts expressed in osteoarthritic cartilage...
  16. Yang Z, Tong Z, Chen Y, Zeng J, Lu F, Sun X, et al. Genetic and functional dissection of HTRA1 and LOC387715 in age-related macular degeneration. PLoS Genet. 2010;6:e1000836 pubmed publisher
    ..on 10q26 influences the risk of age-related macular degeneration (AMD) and encompasses two genes, LOC387715 and HTRA1. Recent data have suggested that loss of LOC387715, mediated by an insertion/deletion (in/del) that destabilizes ..
  17. Zurawa Janicka D, Skorko Glonek J, Lipinska B. HtrA proteins as targets in therapy of cancer and other diseases. Expert Opin Ther Targets. 2010;14:665-79 pubmed publisher
    ..We present characteristics of the human HtrA1, HtrA2 and HtrA3 proteins, with the stress on their function in apoptosis and in the diseases...
  18. Park D, Kim I. Association of ARMS2/HTRA1 variants with polypoidal choroidal vasculopathy phenotype in a Korean population. Jpn J Ophthalmol. 2012;56:60-7 pubmed publisher
    To investigate whether ARMS2 (rs10490924)/HTRA1 (rs11200638) variants are associated with polypoidal choroidal vasculopathy (PCV) in a Korean population and with various PCV phenotypes.
  19. Tiaden A, Klawitter M, Lux V, Mirsaidi A, Bahrenberg G, Glanz S, et al. Detrimental role for human high temperature requirement serine protease A1 (HTRA1) in the pathogenesis of intervertebral disc (IVD) degeneration. J Biol Chem. 2012;287:21335-45 pubmed publisher
    Human HTRA1 is a highly conserved secreted serine protease that degrades numerous extracellular matrix proteins...
  20. Chen W, Xu W, Tao Q, Liu J, Li X, Gan X, et al. Meta-analysis of the association of the HTRA1 polymorphisms with the risk of age-related macular degeneration. Exp Eye Res. 2009;89:292-300 pubmed publisher
    b>HTRA1 was considered as one of important age-related macular degeneration (AMD) candidate genes...
  21. Leveziel N, Zerbib J, Richard F, Querques G, Morineau G, Fremeaux Bacchi V, et al. Genotype-phenotype correlations for exudative age-related macular degeneration associated with homozygous HTRA1 and CFH genotypes. Invest Ophthalmol Vis Sci. 2008;49:3090-4 pubmed publisher
    ..degeneration (AMD) have recently been identified as susceptibility risk factors, including polymorphisms of HTRA1 and CFH genes...
  22. Eigenbrot C, Ultsch M, Lipari M, Moran P, Lin S, Ganesan R, et al. Structural and functional analysis of HtrA1 and its subdomains. Structure. 2012;20:1040-50 pubmed publisher
    The homotrimeric human serine protease HtrA1 is homologous to bacterial HtrA proteases regarding the trypsin-like catalytic and PDZ domains but differs by the presence of an N-terminal domain with IGFBP and Kazal homology...
  23. Narkiewicz J, Klasa Mazurkiewicz D, Zurawa Janicka D, Skorko Glonek J, Emerich J, Lipinska B. Changes in mRNA and protein levels of human HtrA1, HtrA2 and HtrA3 in ovarian cancer. Clin Biochem. 2008;41:561-9 pubmed publisher
    Expression of human HtrA1, HtrA2, HtrA3 and TGF-beta1 genes was examined in ovarian tissue specimens including 19 normal ovaries, 20 benign tumors, 7 borderline tumors, 44 cancers and 8 Krukenberg tumors...
  24. Gibbs D, Yang Z, Constantine R, Ma X, Camp N, Yang X, et al. Further mapping of 10q26 supports strong association of HTRA1 polymorphisms with age-related macular degeneration. Vision Res. 2008;48:685-9 pubmed publisher
    ..A polymorphism (rs11200638) in a transcription factor binding site of the HTRA1 gene has been described, in previous reports, as being most significantly associated with AMD...
  25. Baldi A, De Luca A, Morini M, Battista T, Felsani A, Baldi F, et al. The HtrA1 serine protease is down-regulated during human melanoma progression and represses growth of metastatic melanoma cells. Oncogene. 2002;21:6684-8 pubmed
    ..lymph node metastasis using cDNA arrays indicated down-regulation of PRSS11, a gene encoding the serine protease HtrA1, a homolog of the Escherichia coli protease HtrA, in the metastatic line...
  26. Murwantoko -, Yano M, Ueta Y, Murasaki A, Kanda H, Oka C, et al. Binding of proteins to the PDZ domain regulates proteolytic activity of HtrA1 serine protease. Biochem J. 2004;381:895-904 pubmed
    b>HtrA1, a member of the mammalian HtrA (high temperature requirement A) serine protease family, has a highly conserved protease domain followed by a PDZ domain...
  27. Nie G, Hale K, Li Y, Manuelpillai U, Wallace E, Salamonsen L. Distinct expression and localization of serine protease HtrA1 in human endometrium and first-trimester placenta. Dev Dyn. 2006;235:3448-55 pubmed
    ..b>HtrA1 is a member of the recently identified mammalian HtrA (high temperature requirement factor A) serine protease ..
  28. Chen H, Yang Z, Gibbs D, Yang X, Hau V, Zhao P, et al. Association of HTRA1 polymorphism and bilaterality in advanced age-related macular degeneration. Vision Res. 2008;48:690-4 pubmed publisher
    Single nucleotide polymorphism (SNP), rs11200638, in the promoter of HTRA1 has recently been shown to increase the risk for AMD...
  29. Leveziel N, Souied E, Richard F, Barbu V, Zourdani A, Morineau G, et al. PLEKHA1-LOC387715-HTRA1 polymorphisms and exudative age-related macular degeneration in the French population. Mol Vis. 2007;13:2153-9 pubmed
    ..Protein Family A member 1 (PLEKHA1) gene, rs10490924:G>T at LOC387715, and rs11200638:G>A of HTRA1 (HTRA serine peptidase 1) gene were analyzed in AMD cases (n=118, age=72.3+/-3...
  30. Lu F, Hu J, Zhao P, Lin Y, Yang Y, Liu X, et al. HTRA1 variant increases risk to neovascular age-related macular degeneration in Chinese population. Vision Res. 2007;47:3120-3 pubmed
    ..rs11200638 in the promoter of HTRA1 has recently been shown to increases the risk for wet AMD in both Caucasian and Hong Kong Chinese populations...
  31. Tam P, Ng T, Liu D, Chan W, Chiang S, Chen L, et al. HTRA1 variants in exudative age-related macular degeneration and interactions with smoking and CFH. Invest Ophthalmol Vis Sci. 2008;49:2357-65 pubmed publisher
    ..had not been successful until recent genome-wide association studies revealed Tyr402His in CFH and rs11200638 in HTRA1 as AMD-related genetic variants...
  32. Chien J, Staub J, Hu S, Erickson Johnson M, Couch F, Smith D, et al. A candidate tumor suppressor HtrA1 is downregulated in ovarian cancer. Oncogene. 2004;23:1636-44 pubmed
    We report here that HtrA1, a candidate tumor suppressor, is downregulated in ovarian cancer. Expression of HtrA1 is downregulated in five of seven ovarian cancer cell lines...
  33. Grau S, Baldi A, Bussani R, Tian X, Stefanescu R, Przybylski M, et al. Implications of the serine protease HtrA1 in amyloid precursor protein processing. Proc Natl Acad Sci U S A. 2005;102:6021-6 pubmed
    ..Our data suggest that HtrA1 is directly involved in the beta-amyloid pathway as it degrades various fragments of amyloid precursor protein ..
  34. Luo R, Zhang D, Zhu J, Zhou B, Ma S, Lu F, et al. [Association study on single nucleotide polymorphisms in HTRA1 gene and rheumatoid arthritis]. Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2010;27:305-9 pubmed publisher
    ..To study the association between the single nucleotide polymorphisms (SNPs) in the high-temperature requirement A-1 (HTRA1) gene and rheumatoid arthritis (RA) in Chinese Han population...
  35. Esposito V, Campioni M, De Luca A, Spugnini E, Baldi F, Cassandro R, et al. Analysis of HtrA1 serine protease expression in human lung cancer. Anticancer Res. 2006;26:3455-9 pubmed
    b>HtrA1 is a serine protease homologue to the bacterial serine-protease HtrA, also known as DegP, a heat shock-induced envelope-associated serine protease...
  36. Chen W, Stambolian D, Edwards A, Branham K, Othman M, Jakobsdottir J, et al. Genetic variants near TIMP3 and high-density lipoprotein-associated loci influence susceptibility to age-related macular degeneration. Proc Natl Acad Sci U S A. 2010;107:7401-6 pubmed publisher
    ..Our studies extend the catalog of AMD associated loci, help identify individuals at high risk of disease, and provide clues about underlying cellular pathways that should eventually lead to new therapies. ..
  37. Mori K, Horie Inoue K, Kohda M, Kawasaki I, Gehlbach P, Awata T, et al. Association of the HTRA1 gene variant with age-related macular degeneration in the Japanese population. J Hum Genet. 2007;52:636-41 pubmed
    The purpose of this investigation was to determine whether the high-temperature requirement A-1 (HTRA1) gene polymorphism is associated with age-related macular degeneration (AMD) in native, unrelated Japanese patients...
  38. Losonczy G, Fekete A, Vokó Z, Takacs L, Káldi I, Ajzner E, et al. Analysis of complement factor H Y402H, LOC387715, HTRA1 polymorphisms and ApoE alleles with susceptibility to age-related macular degeneration in Hungarian patients. Acta Ophthalmol. 2011;89:255-62 pubmed publisher
    ..of the complement factor H (CFH) gene, Ser69Ala polymorphism at LOC387715, rs11200638 polymorphism of the HTRA1 gene and different apolipoprotein E (ApoE) alleles in Hungarian patients with AMD in order to determine the ..
  39. Fritsche L, Loenhardt T, Janssen A, Fisher S, Rivera A, Keilhauer C, et al. Age-related macular degeneration is associated with an unstable ARMS2 (LOC387715) mRNA. Nat Genet. 2008;40:892-6 pubmed publisher
    ..10q26 center over two nearby genes, ARMS2 (age-related maculopathy susceptibility 2, also known as LOC387715) and HTRA1 (high-temperature requirement factor A1), suggesting two equally probable candidates...
  40. Lee K, Vithana E, Mathur R, Yong V, Yeo I, Thalamuthu A, et al. Association analysis of CFH, C2, BF, and HTRA1 gene polymorphisms in Chinese patients with polypoidal choroidal vasculopathy. Invest Ophthalmol Vis Sci. 2008;49:2613-9 pubmed publisher
    ..Variants in the CFH and HTRA1/LOC387715 genes are strongly associated with AMD in Caucasians and Chinese...
  41. Tennstaedt A, Pöpsel S, Truebestein L, Hauske P, Brockmann A, Schmidt N, et al. Human high temperature requirement serine protease A1 (HTRA1) degrades tau protein aggregates. J Biol Chem. 2012;287:20931-41 pubmed publisher
    ..So far, however, no HtrA protease is known that degrades protein aggregates. We show here that human HTRA1 degrades aggregated and fibrillar tau, a protein that is critically involved in various neurological disorders...
  42. Kaur I, Katta S, Hussain A, Hussain N, Mathai A, Narayanan R, et al. Variants in the 10q26 gene cluster (LOC387715 and HTRA1) exhibit enhanced risk of age-related macular degeneration along with CFH in Indian patients. Invest Ophthalmol Vis Sci. 2008;49:1771-6 pubmed publisher
    Single nucleotide polymorphisms (SNPs) in the LOC387715 (rs10490924), HTRA1 (rs11200638), and CFH (rs1061170) genes have been implicated in age-related macular degeneration (AMD)...
  43. Yu Y, Bhangale T, Fagerness J, Ripke S, Thorleifsson G, Tan P, et al. Common variants near FRK/COL10A1 and VEGFA are associated with advanced age-related macular degeneration. Hum Mol Genet. 2011;20:3699-709 pubmed publisher
    ..15; P = 8.7 × 10(-9)). In addition to the two novel loci, 10 previously reported loci in ARMS2/HTRA1 (rs10490924), CFH (rs1061170, and rs1410996), CFB (rs641153), C3 (rs2230199), C2 (rs9332739), CFI (rs10033900), ..
  44. Grau S, Richards P, Kerr B, Hughes C, Caterson B, Williams A, et al. The role of human HtrA1 in arthritic disease. J Biol Chem. 2006;281:6124-9 pubmed
    Human HtrA1 belongs to a widely conserved family of serine proteases involved in various aspects of protein quality control and cell fate...
  45. Chien J, He X, Shridhar V. Identification of tubulins as substrates of serine protease HtrA1 by mixture-based oriented peptide library screening. J Cell Biochem. 2009;107:253-63 pubmed publisher
    b>Serine protease HtrA1 belongs to a family of chymotrypsin-like proteases that were first identified in bacteria and later in mammalian systems...
  46. Tsuchihashi T, Mori K, Horie Inoue K, Gehlbach P, Kabasawa S, Takita H, et al. Complement factor H and high-temperature requirement A-1 genotypes and treatment response of age-related macular degeneration. Ophthalmology. 2011;118:93-100 pubmed publisher
    To determine whether there is an association between complement factor H (CFH), high-temperature requirement A-1 (HTRA1), vascular endothelial growth factor (VEGF), and pigment epithelium-derived factor (PEDF) genotypes and response to ..
  47. Yang Z, Camp N, Sun H, Tong Z, Gibbs D, Cameron D, et al. A variant of the HTRA1 gene increases susceptibility to age-related macular degeneration. Science. 2006;314:992-3 pubmed
    ..We demonstrate that a single-nucleotide polymorphism, rs11200638, in the promoter region of HTRA1 is the most likely causal variant for AMD at 10q26 and is estimated to confer a population attributable risk of 49...
  48. Chan C, Shen D, Zhou M, Ross R, Ding X, Zhang K, et al. Human HtrA1 in the archived eyes with age-related macular degeneration. Trans Am Ophthalmol Soc. 2007;105:92-7; discussion 97-8 pubmed
    b>HtrA1 belongs to the high temperature requirement factor A family of serine proteases, which are involved in protein quality control and cell fate...
  49. De Luca A, De Falco M, Severino A, Campioni M, Santini D, Baldi F, et al. Distribution of the serine protease HtrA1 in normal human tissues. J Histochem Cytochem. 2003;51:1279-84 pubmed
    The human HtrA family of proteases consists of three members: HtrA1, HtrA2, and HtrA3...
  50. Zurawa Janicka D, Narkiewicz J, Lipinska B. [Characterization of the HtrA family of proteins]. Postepy Biochem. 2007;53:27-36 pubmed
    The HtrA family of proteins consists of evolutionary conserved serine proteases, which are homologues of the HtrA protein from a model bacterium Escherichia coli...
  51. Kopplin L, Igo R, Wang Y, Sivakumaran T, Hagstrom S, Peachey N, et al. Genome-wide association identifies SKIV2L and MYRIP as protective factors for age-related macular degeneration. Genes Immun. 2010;11:609-21 pubmed publisher
    ..From these efforts, we report the identification of two novel protective factors for AMD and confirm the previously known associations at CFH, ARMS2 and C3. ..
  52. Zhu F, Jin L, Luo T, Luo G, Tan Y, Qin X. Serine protease HtrA1 expression in human hepatocellular carcinoma. Hepatobiliary Pancreat Dis Int. 2010;9:508-12 pubmed
    b>HtrA1, a serine protease, is down-regulated in various human solid tumors. Overexpression of HtrA1 in human cancer cells inhibits cell growth and proliferation in vitro and in vivo, suggesting its possible role as a tumor suppressor...
  53. Bowden M, Di Nezza Cossens L, Jobling T, Salamonsen L, Nie G. Serine proteases HTRA1 and HTRA3 are down-regulated with increasing grades of human endometrial cancer. Gynecol Oncol. 2006;103:253-60 pubmed
    ..Four human HTRA members have been described: HTRA1-4. HTRA1 and HTRA3 share a high degree of domain homologies and may therefore share a functional similarity...
  54. Andreoli M, Morrison M, Kim B, Chen L, Adams S, Miller J, et al. Comprehensive analysis of complement factor H and LOC387715/ARMS2/HTRA1 variants with respect to phenotype in advanced age-related macular degeneration. Am J Ophthalmol. 2009;148:869-74 pubmed publisher
    ..variation of 16 single-nucleotide polymorphisms (SNP) in the complement factor H (CFH) and LOC387715/ARMS2/HTRA1 loci with clinical characteristics of age-related macular degeneration (AMD). Retrospective cohort study...
  55. Clawson G, Bui V, Xin P, Wang N, Pan W. Intracellular localization of the tumor suppressor HtrA1/Prss11 and its association with HPV16 E6 and E7 proteins. J Cell Biochem. 2008;105:81-8 pubmed publisher
    ..We recently identified the protease as high temperature requirement factor A 1 (HtrA1), also known as Prss11, which is member of an oxidative stress-response family of proteases...
  56. Chamberland A, Wang E, Jones A, Collins Racie L, LaVallie E, Huang Y, et al. Identification of a novel HtrA1-susceptible cleavage site in human aggrecan: evidence for the involvement of HtrA1 in aggrecan proteolysis in vivo. J Biol Chem. 2009;284:27352-9 pubmed publisher
    Mass spectrometry-based proteomic analyses performed on cartilage tissue extracts identified the serine protease HtrA1/PRSS11 as a major protein component of human articular cartilage, with elevated levels occurring in association with ..
  57. Truebestein L, Tennstaedt A, Mönig T, Krojer T, Canellas F, Kaiser M, et al. Substrate-induced remodeling of the active site regulates human HTRA1 activity. Nat Struct Mol Biol. 2011;18:386-8 pubmed publisher
    Crystal structures of active and inactive conformations of the human serine protease HTRA1 reveal that substrate binding to the active site is sufficient to stimulate proteolytic activity...
  58. Hara K, Shiga A, Fukutake T, Nozaki H, Miyashita A, Yokoseki A, et al. Association of HTRA1 mutations and familial ischemic cerebral small-vessel disease. N Engl J Med. 2009;360:1729-39 pubmed publisher
    The genetic cause of cerebral autosomal recessive arteriopathy with subcortical infarcts and leukoencephalopathy (CARASIL), which is characterized by ischemic, nonhypertensive, cerebral small-vessel disease with associated alopecia and ..
  59. Narkiewicz J, Lapinska Szumczyk S, Zurawa Janicka D, Skorko Glonek J, Emerich J, Lipinska B. Expression of human HtrA1, HtrA2, HtrA3 and TGF-beta1 genes in primary endometrial cancer. Oncol Rep. 2009;21:1529-37 pubmed
    ..Downregulation of human HtrA1 and HtrA3 genes has been reported in some cancers, including endometrial cancer (EC), suggesting a tumor-..
  60. Chien J, Ota T, Aletti G, Shridhar R, Boccellino M, Quagliuolo L, et al. Serine protease HtrA1 associates with microtubules and inhibits cell migration. Mol Cell Biol. 2009;29:4177-87 pubmed publisher
    b>HtrA1 belongs to a family of serine proteases found in organisms ranging from bacteria to humans...
  61. Zhang L, Lim S, Du H, Zhang M, Kozak I, Hannum G, et al. High temperature requirement factor A1 (HTRA1) gene regulates angiogenesis through transforming growth factor-? family member growth differentiation factor 6. J Biol Chem. 2012;287:1520-6 pubmed publisher
    ..study (GWAS) has identified genetic variants in the promoter region of the high temperature requirement factor A1 (HTRA1) gene associated with age-related macular degeneration (AMD)...
  62. Kondo N, Honda S, Ishibashi K, Tsukahara Y, Negi A. LOC387715/HTRA1 variants in polypoidal choroidal vasculopathy and age-related macular degeneration in a Japanese population. Am J Ophthalmol. 2007;144:608-12 pubmed
    To investigate whether variants in the LOC387715 locus and the HtrA serine peptidase 1 (HTRA1) gene within the 10q26 locus are associated with polypoidal choroidal vasculopathy (PCV) and wet age-related macular degeneration (AMD) in a ..
  63. Shiga A, Nozaki H, Yokoseki A, Nihonmatsu M, Kawata H, Kato T, et al. Cerebral small-vessel disease protein HTRA1 controls the amount of TGF-?1 via cleavage of proTGF-?1. Hum Mol Genet. 2011;20:1800-10 pubmed publisher
    ..disease, cerebral autosomal recessive arteriopathy with subcortical infarcts and leukoencephalopathy (CARASIL)...
  64. He X, Ota T, Liu P, Su C, Chien J, Shridhar V. Downregulation of HtrA1 promotes resistance to anoikis and peritoneal dissemination of ovarian cancer cells. Cancer Res. 2010;70:3109-18 pubmed publisher
    We previously identified serine protease HtrA1 as a downregulated gene in epithelial ovarian cancer (EOC), but the functional consequence of loss of HtrA1 in EOC remains largely unclear...
  65. Dewan A, Liu M, Hartman S, Zhang S, Liu D, Zhao C, et al. HTRA1 promoter polymorphism in wet age-related macular degeneration. Science. 2006;314:989-92 pubmed
    ..Here we report that a single-nucleotide polymorphism in the promoter region of HTRA1, a serine protease gene on chromosome 10q26, is a major genetic risk factor for wet AMD...
  66. Weger M, Renner W, Steinbrugger I, Köfer K, Wedrich A, Groselj Strele A, et al. Association of the HTRA1 -625G>A promoter gene polymorphism with exudative age-related macular degeneration in a Central European population. Mol Vis. 2007;13:1274-9 pubmed
    ..Recently, the HTRA1 -625A allele was identified as a novel risk marker in both a North American and a Chinese population...
  67. Baldi A, Mottolese M, Vincenzi B, Campioni M, Mellone P, Di Marino M, et al. The serine protease HtrA1 is a novel prognostic factor for human mesothelioma. Pharmacogenomics. 2008;9:1069-77 pubmed publisher
    The objective of our study was to analyze the potential prognostic value of the expression of the serine protease HtrA1 and of EGFR in 70 malignant mesotheliomas...
  68. Xu Y, Guan N, Xu J, Yang X, Ma K, Zhou H, et al. Association of CFH, LOC387715, and HTRA1 polymorphisms with exudative age-related macular degeneration in a northern Chinese population. Mol Vis. 2008;14:1373-81 pubmed
    Variants in complement factor H (CFH), the hypothetical LOC387715, and the high-temperature requirement A-1 (HTRA1) genes have been reported to be associated with age-related macular degeneration (AMD)...