HPR

Summary

Gene Symbol: HPR
Description: haptoglobin-related protein
Alias: A-259H10.2, haptoglobin-related protein, Haptoglobin-related locus
Species: human
Products:     HPR

Top Publications

  1. Maeda N, McEvoy S, Harris H, Huisman T, Smithies O. Polymorphisms in the human haptoglobin gene cluster: chromosomes with multiple haptoglobin-related (Hpr) genes. Proc Natl Acad Sci U S A. 1986;83:7395-9 pubmed
    We have found polymorphisms for the number of tandemly arranged haptoglobin-related (Hpr) genes in the haptoglobin gene cluster of Blacks...
  2. Maeda N. Nucleotide sequence of the haptoglobin and haptoglobin-related gene pair. The haptoglobin-related gene contains a retrovirus-like element. J Biol Chem. 1985;260:6698-709 pubmed
    Thirty-three kilobase pairs (kb) of human DNA containing the haptoglobin (Hp) and haptoglobin-related (Hpr) gene pair were cloned, and the nucleotide sequence of 21-kb DNA was determined...
  3. Smith A, Esko J, Hajduk S. Killing of trypanosomes by the human haptoglobin-related protein. Science. 1995;268:284-6 pubmed
    ..An antibody to haptoglobin inhibited TLF activity. TLF was shown to exhibit peroxidase activity and to be inhibited by catalase. These results suggest that TLF kills trypanosomes by oxidative damage initiated by its peroxidase activity. ..
  4. Muranjan M, Nussenzweig V, Tomlinson S. Characterization of the human serum trypanosome toxin, haptoglobin-related protein. J Biol Chem. 1998;273:3884-7 pubmed
    Haptoglobin-related protein (HPR) is a serum protein that is >90% homologous to the acute-phase reactant haptoglobin (Hp). Haptoglobin binds and removes free hemoglobin (Hb) from the circulation...
  5. Nielsen M, Petersen S, Jacobsen C, Oxvig C, Rees D, Møller H, et al. Haptoglobin-related protein is a high-affinity hemoglobin-binding plasma protein. Blood. 2006;108:2846-9 pubmed
    Haptoglobin-related protein (Hpr) is a primate-specific plasma protein associated with apolipoprotein L-I (apoL-I)-containing high-density lipoprotein (HDL) particles shown to be a part of the innate immune defense...
  6. Vanhollebeke B, Nielsen M, Watanabe Y, Truc P, Vanhamme L, Nakajima K, et al. Distinct roles of haptoglobin-related protein and apolipoprotein L-I in trypanolysis by human serum. Proc Natl Acad Sci U S A. 2007;104:4118-23 pubmed
    ..Another HDL component, haptoglobin-related protein (Hpr), has been suggested as an additional toxin required for full trypanolytic activity of normal human serum...
  7. Casado Muñoz M, Benomar N, Ennahar S, Horvatovich P, Lavilla Lerma L, Knapp C, et al. Comparative proteomic analysis of a potentially probiotic Lactobacillus pentosus MP-10 for the identification of key proteins involved in antibiotic resistance and biocide tolerance. Int J Food Microbiol. 2016;222:8-15 pubmed publisher
    ..For example, biocide-adapted Lb. pentosus MP-10 exhibited a down-regulated phosphocarrier protein HPr and an unexpressed oxidoreductase...
  8. Zhu M, Lu Y, Wang J, Li S, Wang X. Carbon Catabolite Repression and the Related Genes of ccpA, ptsH and hprK in Thermoanaerobacterium aotearoense. PLoS ONE. 2015;10:e0142121 pubmed publisher
    ..The highly purified Histidine-containing Protein (HPr) could be specifically phosphorylated at Serine 46 by HPr kinase/phosphatase (HPrK/P) with no need to add fructose-..
  9. Zébré A, Aké F, Ventroux M, Koffi Nevry R, Noirot Gros M, Deutscher J, et al. Interaction with enzyme IIBMpo (EIIBMpo) and phosphorylation by phosphorylated EIIBMpo exert antagonistic effects on the transcriptional activator ManR of Listeria monocytogenes. J Bacteriol. 2015;197:1559-72 pubmed publisher
    ..activated via the phosphorylation of His585 in the EIIA(Man)-like domain by the general PTS components enzyme I and HPr. We also show that ManR is regulated by the PTS(Mpo) and that EIIB(Mpo) plays a dual role in ManR regulation...

More Information

Publications113 found, 100 shown here

  1. Bruder M, Pyne M, Moo Young M, Chung D, Chou C. Extending CRISPR-Cas9 Technology from Genome Editing to Transcriptional Engineering in the Genus Clostridium. Appl Environ Microbiol. 2016;82:6109-6119 pubmed
    ..acetobutylicum through transcriptional repression of the hprK gene encoding HPr kinase/phosphorylase, leading to the coutilization of glucose and xylose, which are two abundant carbon sources ..
  2. Xu C, Ma C, Bai Y. A pediatric hypophosphatemic rickets on MRI, 99mTc-MDP bone scan and 18F-FDG PET/CT. Hell J Nucl Med. 2017;20:93-96 pubmed publisher
    ..Based on these findings we suggested the diagnosis of hypophosphatemic rickets (HPR). Phosphate and vitamin D substitution resulted in clinical improvement of the symptoms after 3 months.
  3. Weitkunat K, Stuhlmann C, Postel A, Rumberger S, Fankhänel M, Woting A, et al. Short-chain fatty acids and inulin, but not guar gum, prevent diet-induced obesity and insulin resistance through differential mechanisms in mice. Sci Rep. 2017;7:6109 pubmed publisher
    ..dietary fibres (either cellulose, inulin or guar gum) or different Ac:Pr ratios (high acetate (HAc) or propionate (HPr)) for 30 weeks...
  4. Hirooka K, Kodoi Y, Satomura T, Fujita Y. Regulation of the rhaEWRBMA Operon Involved in l-Rhamnose Catabolism through Two Transcriptional Factors, RhaR and CcpA, in Bacillus subtilis. J Bacteriol. 2015;198:830-45 pubmed publisher
    ..Moreover, it was demonstrated that the CcpA/P-Ser-HPr complex, primarily governing the carbon catabolite control in B...
  5. Toro Ascuy D, Tambley C, Beltran C, Mascayano C, Sandoval N, Olivares E, et al. Development of a reverse genetic system for infectious salmon anemia virus: rescue of recombinant fluorescent virus by using salmon internal transcribed spacer region 1 as a novel promoter. Appl Environ Microbiol. 2015;81:1210-24 pubmed
    ..We generated three recombinant viruses, wild-type rISAV(901_09) and rISAVr(S6-NotI-HPR) containing a NotI restriction site and rISAV(S6/EGFP-HPR) harboring the open reading frame of enhanced green ..
  6. Joyet P, Derkaoui M, Bouraoui H, Deutscher J. PTS-Mediated Regulation of the Transcription Activator MtlR from Different Species: Surprising Differences despite Strong Sequence Conservation. J Mol Microbiol Biotechnol. 2015;25:94-105 pubmed publisher
    ..casei MtlR is not phosphorylated by Enzyme I (EI) and HPr. When the corresponding His in PRD2 of MtlR from B. subtilis and G...
  7. Bäumler H, Georgieva R. Coupled enzyme reactions in multicompartment microparticles. Biomacromolecules. 2010;11:1480-7 pubmed publisher
    ..When fluorogenic substrates for beta-Glu and HPR were used, the start and the end of the coupled enzyme reaction were visualized and recorded inside of individual ..
  8. Ahouty B, Koffi M, Ilboudo H, Simo G, Matovu E, Mulindwa J, et al. Candidate genes-based investigation of susceptibility to Human African Trypanosomiasis in Côte d'Ivoire. PLoS Negl Trop Dis. 2017;11:e0005992 pubmed publisher
    ..tested using 96 SNPs in16 candidate genes (IL1, IL4, IL4R, IL6, IL8, IL10, IL12, IL12R, TNFA, INFG, MIF, APOL1, HPR, CFH, HLA-A and HLA-G). Data from 77 SNPs passed quality control...
  9. Kozlitina J, Zhou H, BROWN P, Rohm R, Pan Y, Ayanoglu G, et al. Plasma Levels of Risk-Variant APOL1 Do Not Associate with Renal Disease in a Population-Based Cohort. J Am Soc Nephrol. 2016;27:3204-3219 pubmed
    ..Genetic association studies implicated variants in loci harboring haptoglobin-related protein (HPR), APOL1, and ubiquitin D (UBD) in the regulation of plasma APOL1 levels, but these variants did not associate with ..
  10. Wang Q, Millet Y, Chao M, Sasabe J, Davis B, Waldor M. A Genome-Wide Screen Reveals that the Vibrio cholerae Phosphoenolpyruvate Phosphotransferase System Modulates Virulence Gene Expression. Infect Immun. 2015;83:3381-95 pubmed publisher
    ..the genes known to modulate tcpA expression, the screen yielded ptsI and ptsH, which encode the enzyme I (EI) and Hpr components of the V. cholerae phosphoenolpyruvate phosphotransferase system (PTS)...
  11. Lengeler J. PTS 50: Past, Present and Future, or Diauxie Revisited. J Mol Microbiol Biotechnol. 2015;25:79-93 pubmed publisher
    ..The system comprised proteins named Enzyme I, HPr and Enzymes II, as part of a novel PTS for carbohydrates in Gram-negative and Gram-positive bacteria, whose '..
  12. Morad S, Tan S, Feith D, Kester M, Claxton D, Loughran T, et al. Modification of sphingolipid metabolism by tamoxifen and N-desmethyltamoxifen in acute myelogenous leukemia--Impact on enzyme activity and response to cytotoxics. Biochim Biophys Acta. 2015;1851:919-28 pubmed publisher
    ..The co-administration of tamoxifen with either N-(4-hydroxyphenyl)retinamide (4-HPR), a ceramide-generating retinoid, or a cell-deliverable form of ceramide, C6-ceramide, resulted in marked decreases ..
  13. Iyer B, Rajput M, Jog R, Joshi E, Bharwad K, Rajkumar S. Organic acid mediated repression of sugar utilization in rhizobia. Microbiol Res. 2016;192:211-220 pubmed publisher
    ..Deletion of hpr and sma0113 resulted in the partial relief of SMCR of utilization of galactosides like lactose, raffinose and ..
  14. Corpas F, Barroso J. Lead-induced stress, which triggers the production of nitric oxide (NO) and superoxide anion (O2·-) in Arabidopsis peroxisomes, affects catalase activity. Nitric Oxide. 2017;68:103-110 pubmed publisher
    ..catalase (CAT) and two photorespiration enzymes, such as glycolate oxidase (GOX) and hydroxypyruvate reductase (HPR), show that, under Pb-stress, only the catalase was negatively affected, while the two photorespiration enzymes ..
  15. Udaondo Z, Duque E, Ramos J. The pangenome of the genus Clostridium. Environ Microbiol. 2017;19:2588-2603 pubmed publisher
    ..Network analysis identified four nodes that function as hubs and bottlenecks, namely, coenzyme A, HPr kinases, S-adenosylmethionine and the ribonuclease P-protein, suggesting pivotal roles for them in Clostridium.
  16. Kant S, Agarwal S, Pancholi P, Pancholi V. The Streptococcus pyogenes orphan protein tyrosine phosphatase, SP-PTP, possesses dual specificity and essential virulence regulatory functions. Mol Microbiol. 2015;97:515-40 pubmed publisher
    ..GAS genes, including several virulence genes potentially through the two-component regulators, CovR, WalR and PTS/HPr regulation of Mga...
  17. Aymerich J, Márquez A, Terés L, Muñoz Berbel X, Jimenez C, Dominguez C, et al. Cost-effective smartphone-based reconfigurable electrochemical instrument for alcohol determination in whole blood samples. Biosens Bioelectron. 2018;117:736-742 pubmed publisher
    ..is enabled by in situ electrodeposition of a calcium alginate hydrogel containing horseradish peroxidase (HPR) and alcohol oxidase (AOx) for selective ethanol detection...
  18. Zeng Y, Bao J, Zhao Y, Huo D, Chen M, Qi Y, et al. A sandwich-type electrochemical immunoassay for ultrasensitive detection of non-small cell lung cancer biomarker CYFRA21-1. Bioelectrochemistry. 2018;120:183-189 pubmed publisher
    ..thionine linking, which provides more amino groups to capture more horseradish peroxidase-labeled antibodies (HPR-Ab2) and enhances the conductivity...
  19. Weckerle A, Snipes J, Cheng D, Gebre A, Reisz J, Murea M, et al. Characterization of circulating APOL1 protein complexes in African Americans. J Lipid Res. 2016;57:120-30 pubmed publisher
    ..Proteomic analysis revealed that complex A was composed of APOA1, haptoglobin-related protein (HPR), and complement C3, whereas complex B contained APOA1, HPR, IgM, and fibronectin...
  20. Jans D, Martin A. Nucleocytoplasmic Trafficking of Dengue Non-structural Protein 5 as a Target for Antivirals. Adv Exp Med Biol. 2018;1062:199-213 pubmed publisher
    ..N-(4-hydroxyphenyl) retinamide (4-HPR) is of particular interest as a specific, non-toxic inhibitor able to protect against infection by all four ..
  21. Wang S, Zhang R, Wang T, Jiang F, Hu C, Jia W. Association of the genetic variant rs2000999 with haptoglobin and diabetic macrovascular diseases in Chinese patients with type 2 diabetes. J Diabetes Complications. 2018;: pubmed publisher
    ..aimed to investigate the relationship of the genetic variant rs2000999, located in the haptoglobin-related protein (HPR) gene, with serum Hp levels and diabetic macrovascular diseases in Chinese type 2 diabetes patients...
  22. Sauvageot N, Ladjouzi R, Benachour A, Rincé A, Deutscher J, Hartke A. Aerobic glycerol dissimilation via the Enterococcus faecalis DhaK pathway depends on NADH oxidase and a phosphotransfer reaction from PEP to DhaK via EIIADha. Microbiology. 2012;158:2661-6 pubmed
    ..cascade which phosphorylates dihydroxyacetone in a phosphoenolpyruvate (PEP)-dependent reaction via EI, HPr, EF1359 and DhaLK...
  23. Mukherjee N, Reuland S, Lu Y, Luo Y, Lambert K, Fujita M, et al. Combining a BCL2 inhibitor with the retinoid derivative fenretinide targets melanoma cells including melanoma initiating cells. J Invest Dermatol. 2015;135:842-850 pubmed publisher
    ..The synthetic retinoid fenretinide N-(4-hydroxyphenyl)retinamide (4-HPR) has shown promise for treating breast cancers...
  24. Hasanzadeh M, Solhi E, Jafari M, Mokhtarzadeh A, Soleymani J, Jouyban A, et al. Ultrasensitive immunoassay of tumor protein CA 15.3 in MCF-7 breast cancer cell lysates and unprocessed human plasma using gold nanoparticles doped on the structure of mesoporous silica. Int J Biol Macromol. 2018;: pubmed publisher
    ..thionine linking, which provides more amino groups to capture more horseradish peroxidase-labeled antibodies (HPR-Ab2) and enhances the conductivity...
  25. Liu L, Chen S, Wu J. Phosphoenolpyruvate:glucose phosphotransferase system modification increases the conversion rate during L-tryptophan production in Escherichia coli. J Ind Microbiol Biotechnol. 2017;44:1385-1395 pubmed publisher
    ..phosphotransferase system (PTS) was disrupted by deleting the ptsH gene, which encodes the phosphocarrier protein (HPr). The levels of biomass, L-tryptophan yield, and conversion rate of this strain, E...
  26. Tantry U, Gurbel P. Antiplatelet drug resistance and variability in response: the role of antiplatelet therapy monitoring. Curr Pharm Des. 2013;19:3795-815 pubmed
    ..coronary intervention (PCI)-treated population receiving clopidogrel have identified high platelet reactivity (HPR) to adenosine diphosphate as a major risk factor for both acute as well as long-term ischemic event occurrence, ..
  27. Chen Y, Liu Y, Ding D, Cong L, Zhang D. Rational design and analysis of an Escherichia coli strain for high-efficiency tryptophan production. J Ind Microbiol Biotechnol. 2018;45:357-367 pubmed publisher
    ..To further improve the production of L-trp, pyruvate kinase (pykF) and the phosphotransferase system HPr (ptsH) were deleted after inactivation of repression (trpR) and attenuation (attenuator) to produce strain KW006...
  28. Othim S, Ramasamy S, Kahuthia Gathu R, Dubois T, Ekesi S, Fiaboe K. Expression of Resistance in Amaranthus spp. (Caryophyllales: Amaranthaceae): Effects of Selected Accessions on the Behaviour and Biology of the Amaranth Leaf-Webber, Spoladea recurvalis (Lepidoptera: Crambidae). Insects. 2018;9: pubmed publisher
    ..Host plant resistance (HPR) to insects is an effective, economical and environmentally friendly alternative that is poorly understood and ..
  29. Kumar G, Sivagurunathan P, Park J, Park J, Park H, Yoon J, et al. HRT dependent performance and bacterial community population of granular hydrogen-producing mixed cultures fed with galactose. Bioresour Technol. 2016;206:188-194 pubmed publisher
    ..A peak hydrogen production rate (HPR) of 25...
  30. Boppana N, Kraveka J, Rahmaniyan M, Li L, Bielawska A, Bielawski J, et al. Fumonisin B1 Inhibits Endoplasmic Reticulum Stress Associated-apoptosis After FoscanPDT Combined with C6-Pyridinium Ceramide or Fenretinide. Anticancer Res. 2017;37:455-463 pubmed
    Combining an anticancer agent fenretinide (HPR) or C6-pyridinium ceramide (LCL29) with Foscan-mediated photodynamic therapy (FoscanPDT) is expected to augment anticancer benefits of each substance...
  31. Redfors B, Généreux P, Witzenbichler B, McAndrew T, Diamond J, Huang X, et al. Percutaneous Coronary Intervention of Saphenous Vein Graft. Circ Cardiovasc Interv. 2017;10: pubmed publisher
    ..the second-generation drug-eluting stent use within SVG, and the relative importance of high platelet reactivity (HPR) in SVG PCI versus native lesion PCI is unknown...
  32. Zeng S, Wang Z, Gao J, Liu D, Zhang D, Lu P. [On-line Estimation for the Amount of Stored PHA in Activated Sludge Based on OUR-HPR Measurements]. Huan Jing Ke Xue. 2015;36:1713-9 pubmed
    ..products (SSAG-SMP), it is assumed that there is the linear relationship between the PHA synthesized and OUR or HPR, respectively...
  33. He M, Liu B, Sun D, Pan Y, Zheng W, Shi J, et al. One-quarter standard-dose ticagrelor better than standard-dose clopidogrel in Chinese patients with stable coronary artery disease: A randomized, single-blind, crossover clinical study. Int J Cardiol. 2016;215:209-13 pubmed publisher
    ..03±51.38 versus 163.77±58.66, P<0.01). High-platelet reactivity (HPR) (?208 PRU) was 0% with ticagrelor and 16.67% with clopidogrel...
  34. Antunes A, Derkaoui M, Terrade A, Denizon M, Deghmane A, Deutscher J, et al. The Phosphocarrier Protein HPr Contributes to Meningococcal Survival during Infection. PLoS ONE. 2016;11:e0162434 pubmed publisher
    ..via the phosphoenolpyruvate (PEP):sugar phosphotransferase system (PTS), in which the phosphocarrier protein HPr (encoded by the ptsH gene) plays a central role. Although N...
  35. Morad S, Davis T, Kester M, Loughran T, Cabot M. Dynamics of ceramide generation and metabolism in response to fenretinide--Diversity within and among leukemia. Leuk Res. 2015;39:1071-8 pubmed publisher
    Fenretinide, N-(4-hydroxyphenyl)retinamide, (4-HPR), a synthetic retinoid, owes its cancer-toxic effects in part to the generation of ceramide, a potent tumor-suppressing sphingolipid...
  36. Larsen P, Holley A, Sasse A, Al Sinan A, Fairley S, Harding S. Comparison of Multiplate and VerifyNow platelet function tests in predicting clinical outcome in patients with acute coronary syndromes. Thromb Res. 2017;152:14-19 pubmed publisher
    ..01). MACE occurred in 16% of those classified as having HPR using VerifyNow compared to 7% in those without HPR (odds ratio of 2.6 (95% CI 1.5-4.4, p=0.001)...
  37. De Rosa R, Palmerini T, De Servi S, Belmonte M, Crimi G, Cornara S, et al. High on-treatment platelet reactivity and outcome in elderly with non ST-segment elevation acute coronary syndrome - Insight from the GEPRESS study. Int J Cardiol. 2018;259:20-25 pubmed publisher
    ..We aimed to investigate the association between high on-treatment platelet reactivity (HPR) and long-term outcome in elderly with non-ST-elevated acute coronary syndromes (NSTE-ACS) undergoing PCI...
  38. Rilinger J, Meyer M, Schnabel K, Weik P, Charlet A, Esser J, et al. High platelet reactivity after P2Y12-inhibition in patients with atrial fibrillation and coronary stenting. J Thromb Thrombolysis. 2016;42:558-65 pubmed publisher
    High platelet reactivity (HPR) after P2Y12-inhibition in patients undergoing coronary stenting is associated with an increased risk for thromboembolic events and coronary death...
  39. Bagai A, Peterson E, McCoy L, Effron M, Zettler M, Stone G, et al. Association of measured platelet reactivity with changes in P2Y12 receptor inhibitor therapy and outcomes after myocardial infarction: Insights into routine clinical practice from the TReatment with ADP receptor iNhibitorS: Longitudinal Assessment of. Am Heart J. 2017;187:19-28 pubmed publisher
    ..Intensification of antiplatelet therapy was associated with lower risk of ischemic events at 1year among HPR patients.
  40. Hummel T, Meves S, Rüdiger K, Mügge A, Mumme A, Burkert B, et al. [Prevalence of acetylsalicylic acid (ASA) - low response in vascular surgery]. Chirurg. 2016;87:446-54 pubmed publisher
    ..has revealed that a decreased antiplatelet effect (low response [LR]/high on-treatment platelet reactivity [HPR]) of acetylsalicylic acid (ASA) and clopidogrel is associated with an increased risk of thromboembolic events...
  41. Naseer M, Chaudhary A, Rasool M, Kalamegam G, Ashgan F, Assidi M, et al. Copy number variations in Saudi family with intellectual disability and epilepsy. BMC Genomics. 2016;17:757 pubmed
    ..0.6.6 softwear. Copy number gain were observed in the chromosome 1, 16 and 22 with LCE3C, HPR, GSTT2, GSTTP2, DDT and DDTL genes respectively whereas the deletions observed in the chromosomal regions 8p23-p21 (..
  42. Sabnis N, Miller A, Titus M, Huss W. The Efflux Transporter ABCG2 Maintains Prostate Stem Cells. Mol Cancer Res. 2017;15:128-140 pubmed publisher
    ..Using the HPr-1-AR (nontumorigenic) and CWR-R1 (tumorigenic) prostate cell lines, it was demonstrated that inhibiting the ABCG2-..
  43. Zhu S, Hegemann J, Fage C, Zimmermann M, Xie X, Linne U, et al. Insights into the Unique Phosphorylation of the Lasso Peptide Paeninodin. J Biol Chem. 2016;291:13662-78 pubmed publisher
    ..Furthermore, through comparison with homologous HPr kinases and subsequent mutational analysis, we confirmed the essential catalytic residues...
  44. Mikkelsson J, Paana T, Lepäntalo A, Karjalainen P. Personalized ADP-receptor inhibition strategy and outcomes following primary PCI for STEMI (PASTOR study). Int J Cardiol. 2016;202:463-6 pubmed publisher
    ..to investigate whether STEMI patients switched to novel ADP receptor inhibitors due to high platelet reactivity (HPR) on clopidogrel have similar outcomes compared to patients with adequate response to clopidogrel...
  45. Giustino G, Kirtane A, Baber U, Genereux P, Witzenbichler B, Neumann F, et al. Impact of Anemia on Platelet Reactivity and Ischemic and Bleeding Risk: From the Assessment of Dual Antiplatelet Therapy With Drug-Eluting Stents Study. Am J Cardiol. 2016;117:1877-83 pubmed publisher
    ..Platelet reactivity was measured with VerifyNow assay; high platelet reactivity (HPR) on clopidogrel was defined as platelet reactive units value >208...
  46. Kim I, Jeong Y, Park Y, Yoon S, Kwon T, Park J, et al. Interaction analysis between genetic polymorphisms and pharmacodynamic effect in patients treated with adjunctive cilostazol to dual antiplatelet therapy: results of the ACCEL-TRIPLE (Accelerated Platelet Inhibition by Triple Antiplatelet Therapy Acc. Br J Clin Pharmacol. 2012;73:629-40 pubmed publisher
    ..High on-treatment platelet reactivity (HPR) was defined as 5 µm ADP-induced maximal platelet reactivity (Agg(max) ) >46%...
  47. Garcia De Gonzalo C, Denham E, Mars R, Stülke J, van der Donk W, van Dijl J. The phosphoenolpyruvate:sugar phosphotransferase system is involved in sensitivity to the glucosylated bacteriocin sublancin. Antimicrob Agents Chemother. 2015;59:6844-54 pubmed publisher
    ..our present mutagenesis and genomic studies demonstrate that the histidine-containing phosphocarrier protein (HPr) and domain A of enzyme II (PtsG) in particular are critical determinants for bacterial sensitivity to sublancin.
  48. Li S, Choi J, Guo L, Goh R, Kim B, Woo K, et al. Correlation between the CYP2C19 phenotype status and the results of three different platelet function tests in cardiovascular disease patients receiving antiplatelet therapy: an emphasis on newly introduced platelet function analyzer-200 P2Y test. Ann Lab Med. 2016;36:42-8 pubmed publisher
    ..2±60.5, 171.5±42.6, and 218.7±59.3, respectively, P<0.001). The high residual platelet reactivity (HPR) rates were significantly different among the EM, IM, and PM groups using PFA-200 (PM:IM:EM=82.4:40.6:11.8, P<0...
  49. Pourdjabbar A, Hibbert B, Chong A, Le May M, Labinaz M, Simard T, et al. A randomised study for optimising crossover from ticagrelor to clopidogrel in patients with acute coronary syndrome. The CAPITAL OPTI-CROSS Study. Thromb Haemost. 2017;117:303-310 pubmed publisher
    ..Secondary outcomes included: PRUs at each time point, incidence of high on-treatment platelet reactivity (HPR), major adverse cardiac events (MACE) and TIMI bleeding at 30 days...
  50. Siasos G, Oikonomou E, Zaromitidou M, Kioufis S, Kokkou E, Mourouzis K, et al. Clopidogrel response variability is associated with endothelial dysfunction in coronary artery disease patients receiving dual antiplatelet therapy. Atherosclerosis. 2015;242:102-8 pubmed publisher
    ..showed that for every decrease in FMD by 1% there is an anticipated increased in the odds of patients to have HPR by 1.66 (95% CI 1.03-2.57, p = 0.037)...
  51. Li S, Ma Y, Wei D. Identification of an interaction between EI and a histidine kinase-response regulator hybrid protein in Gluconobacter oxydans. Biochem Biophys Res Commun. 2016;470:331-335 pubmed publisher
    ..an incomplete phosphoenolpyruvate: carbohydrate phosphotransferase system consisting of three components--EI, HPr and EIIA, while the function of individual members of the system remains unknown...
  52. Yun K, Mintz G, Witzenbichler B, Inaba S, Shimizu T, Metzger D, et al. Relationship Between Platelet Reactivity and Culprit Lesion Morphology: An Assessment From the ADAPT-DES Intravascular Ultrasound Substudy. JACC Cardiovasc Imaging. 2016;9:849-854 pubmed publisher
    ..Recent studies have reported that high on-treatment platelet reactivity (HPR) is associated with higher plaque volume and the presence of multivessel disease; however, the association between ..
  53. Chen C, Dienhart J, Bolton E. Androgen-Sensitized Apoptosis of HPr-1AR Human Prostate Epithelial Cells. PLoS ONE. 2016;11:e0156145 pubmed publisher
    ..Here, we report that androgen sensitizes HPr-1AR and RWPE-AR human prostate epithelial cells to cell stress agents and apoptotic cell death...
  54. Ciotti S, Battaglia E, Carbonaro N, Bicchi A, Tognetti A, Bianchi M. A Synergy-Based Optimally Designed Sensing Glove for Functional Grasp Recognition. Sensors (Basel). 2016;16: pubmed publisher
    ..However, the intrinsic accuracy (as well as the number of sensing elements) of wearable hand pose reconstruction (HPR) systems can be severely limited by ergonomics and cost considerations...
  55. Sivagurunathan P, Anburajan P, Kumar G, Park J, Kim S. Recovering hydrogen production performance of upflow anaerobic sludge blanket reactor (UASBR) fed with galactose via repeated heat treatment strategy. Bioresour Technol. 2017;240:207-213 pubmed publisher
    ..The hydrogen production rate (HPR) and hydrogen yield (HY) gradually increased up to 9.1L/L/d and 1...
  56. Rollini F, Franchi F, Cho J, Degroat C, Bhatti M, Muniz Lozano A, et al. A head-to-head pharmacodynamic comparison of prasugrel vs. ticagrelor after switching from clopidogrel in patients with coronary artery disease: results of a prospective randomized study. Eur Heart J. 2016;37:2722-30 pubmed publisher
    ..24 h post-LD. Rates of high platelet reactivity (HPR) were markedly reduced and similar between groups...
  57. Clavijo L, Dhillon A, Al Asady N, Matthews R, Caro J, Tun H, et al. Switch to Ticagrelor in critical limb ischemia antiplatelet study (STT-CLIPS). Cardiovasc Revasc Med. 2018;19:319-323 pubmed publisher
    ..High on-treatment platelet reactivity (HPR) is highly prevalent in patients with CLI treated with clopidogrel...
  58. Zagrodnik R, Laniecki M. The role of pH control on biohydrogen production by single stage hybrid dark- and photo-fermentation. Bioresour Technol. 2015;194:187-95 pubmed publisher
    ..Increasing pH during dark fermentation resulted in lower hydrogen production rate (HPR) and longer lag time for both controlled and uncontrolled conditions...
  59. Musso L, Tiberio P, Appierto V, Cincinelli R, Cavadini E, Cleris L, et al. Water-soluble derivatives of 4-oxo-N-(4-hydroxyphenyl) retinamide: synthesis and biological activity. Chem Biol Drug Des. 2016;88:608-14 pubmed publisher
    A novel series of 4-oxo-N-(4-hydroxyphenyl) retinamide (4-oxo-4-HPR) derivatives were synthesized with the aim of increasing the poor solubility of the parent compound in biological fluids, while maintaining the cytotoxic activity and ..
  60. Godschalk T, Byrne R, Adriaenssens T, Malik N, Feldman L, Guagliumi G, et al. Observational Study of Platelet Reactivity in Patients Presenting With ST-Segment Elevation Myocardial Infarction Due to Coronary Stent Thrombosis Undergoing Primary Percutaneous Coronary Intervention: Results From the European PREvention of Stent Th. JACC Cardiovasc Interv. 2017;10:2548-2556 pubmed publisher
    High platelet reactivity (HPR) was studied in patients presenting with ST-segment elevation myocardial infarction (STEMI) due to stent thrombosis (ST) undergoing immediate percutaneous coronary intervention (PCI)...
  61. Krümpel J, Schäufele F, Schneider J, Jungbluth T, Zielonka S, Lemmer A. Kinetics of biogas production in Anaerobic Filters. Bioresour Technol. 2016;200:230-4 pubmed publisher
    ..1gCOD in the form of acetic (HAc), propionic (HPr) or butyric acid (HBu) was injected into the AF while operating at an organic loading rate (OLRCOD) of 3...
  62. Erickson L, Kim H, Maeda N. Junctions between genes in the haptoglobin gene cluster of primates. Genomics. 1992;14:948-58 pubmed
    ..the haptoglobin three-gene cluster in Old World primates, we sequenced the region between the second gene (HPR) and the third gene (HPP) in chimpanzees (15 kb), as well as the region 3' to the cluster in humans (14 kb)...
  63. Homburg C, Bommer M, Wuttge S, Hobe C, Beck S, Dobbek H, et al. Inducer exclusion in Firmicutes: insights into the regulation of a carbohydrate ATP binding cassette transporter from Lactobacillus casei BL23 by the signal transducing protein P-Ser46-HPr. Mol Microbiol. 2017;105:25-45 pubmed publisher
    ..This process is termed inducer exclusion. In bacteria belonging to the phylum Firmicutes, HPr, phosphorylated at serine 46 (P-Ser46-HPr) is the key player but its mode of action is elusive...
  64. Wang C, Yang S, Smith K, Forwood J, Jans D. Nuclear import inhibitor N-(4-hydroxyphenyl) retinamide targets Zika virus (ZIKV) nonstructural protein 5 to inhibit ZIKV infection. Biochem Biophys Res Commun. 2017;493:1555-1559 pubmed publisher
    ..that this interaction can be blocked by the novel DENV NS5 targeting inhibitor N-(4-hydroxyphenyl) retinamide (4-HPR). Importantly, we show that 4-HPR has potent anti-ZIKV activity at low ?M concentrations...
  65. Harrington J, Nishanova T, Pena S, Hess M, Scelsi C, Widener J, et al. A retained secretory signal peptide mediates high density lipoprotein (HDL) assembly and function of haptoglobin-related protein. J Biol Chem. 2014;289:24811-20 pubmed publisher
    Haptoglobin-related protein (Hpr) is a component of a minor subspecies of high density lipoproteins (HDL) that function in innate immunity...
  66. Lopes H, Ramos L, Silva E. Co-Fermentation of Cheese Whey and Crude Glycerol in EGSB Reactor as a Strategy to Enhance Continuous Hydrogen and Propionic Acid Production. Appl Biochem Biotechnol. 2017;183:712-728 pubmed publisher
    ..19 mmol HPr g COD-1 at the CW/CG ratio of 5:3. Moreover, by reducing HRT of 8 to 0...
  67. Giustino G, Redfors B, Mehran R, Kirtane A, Baber U, Genereux P, et al. Sex differences in the effect of diabetes mellitus on platelet reactivity and coronary thrombosis: From the Assessment of Dual Antiplatelet Therapy with Drug-Eluting Stents (ADAPT-DES) study. Int J Cardiol. 2017;246:20-25 pubmed publisher
    ..We investigated the sex-specific effect of DM on high on-clopidogrel platelet reactivity (HPR), defined as a P2Y12 reaction units ?208, and the adjusted association of DM on the 2-year risk for ..
  68. Takahashi N, Koyama S, Hasegawa S, Yamasaki M, Imai M. Anticancer efficacy of p-dodecylaminophenol against high-risk and refractory neuroblastoma cells in vitro and in vivo. Bioorg Med Chem Lett. 2017;27:4664-4672 pubmed publisher
    ..We have developed p-dodecylaminophenol (3, p-DDAP), based on N-(4-hydroxyphenyl)retinamide (2, 4-HPR), a synthetic amide of 1, since 1 and 2 are associated with the side-effect of nyctalopia...
  69. Lu C, Zhang Z, Zhou X, Hu J, Ge X, Xia C, et al. Effect of substrate concentration on hydrogen production by photo-fermentation in the pilot-scale baffled bioreactor. Bioresour Technol. 2018;247:1173-1176 pubmed publisher
    ..The relationships between parameters, such as hydrogen production rate (HPR, mol H2/m3/d), hydrogen concentration, pH value, oxidation-reduction potential, biomass ..
  70. Clifton E, Tylka G, Gassmann A, Hodgson E. Interactions of host-plant-resistance and seed treatments on soybean aphid (Aphis glycines Matsumura) and soybean cyst nematode (Heterodera glycines Ichinohe). Pest Manag Sci. 2017;: pubmed publisher
    ..A three-year field study and complementary greenhouse experiment were conducted to determine the benefits of host-plant resistance (HPR) and pesticidal seed treatments for managing pest populations and preserving soybean yield.
  71. Rodionova I, Goodacre N, Babu M, Emili A, Uetz P, Saier M. The Nitrogen Regulatory PII Protein (GlnB) and N-Acetylglucosamine 6-Phosphate Epimerase (NanE) Allosterically Activate Glucosamine 6-Phosphate Deaminase (NagB) in Escherichia coli. J Bacteriol. 2018;200: pubmed publisher
    ..6-phosphate (GlcNAc-6P) and the phosphocarrier protein of the bacterial phosphotransferase system, HPr, in Escherichia coli We provide evidence that NanE, GlcNAc-6P epimerase, and the uridylylated PII protein (U-..
  72. Warner J, Krom B, Magni C, Konings W, Lolkema J. Catabolite repression and induction of the Mg(2+)-citrate transporter CitM of Bacillus subtilis. J Bacteriol. 2000;182:6099-105 pubmed
    ..Studies with B. subtilis mutants defective in the catabolite repression components HPr, Crh, and CcpA showed that the repression exerted by all these medium components was mediated via the carbon ..
  73. Carter E, Sato K, Morio Y, McMurtry I. Inhibition of K(Ca) channels restores blunted hypoxic pulmonary vasoconstriction in rats with cirrhosis. Am J Physiol Lung Cell Mol Physiol. 2000;279:L903-10 pubmed
    ..was to investigate the roles of nitric oxide (NO) and endothelin-1 (ET-1) in the blunted hypoxic pressor response (HPR) in rats with common bile duct ligation (CBDL)...
  74. Froguel P, Ndiaye N, Bonnefond A, Bouatia Naji N, Dechaume A, Siest G, et al. A genome-wide association study identifies rs2000999 as a strong genetic determinant of circulating haptoglobin levels. PLoS ONE. 2012;7:e32327 pubmed publisher
  75. Guthrie P, Rodriguez S, Gaunt T, Lawlor D, Smith G, Day I. Complexity of a complex trait locus: HP, HPR, haemoglobin and cholesterol. Gene. 2012;499:8-13 pubmed publisher
    HP and HPR are related and contiguous genes in strong linkage disequilibrium (LD), encoding haptoglobin and haptoglobin-related protein. These bind and chaperone free Hb for recycling, protecting against oxidation...
  76. Strickland M, Stanley A, Wang G, Botos I, Schwieters C, Buchanan S, et al. Structure of the NPr:EINNtr Complex: Mechanism for Specificity in Paralogous Phosphotransferase Systems. Structure. 2016;24:2127-2137 pubmed publisher
    ..We investigated HPr:EIsugar and NPr:EINtr, the initial complexes of paralogous phosphorylation cascades involved ..
  77. Young D, Estocado N, Feng D, Black J. The Development and Preliminary Validity Testing of the Healing Progression Rate Tool. Ostomy Wound Manage. 2017;63:32-44 pubmed
    ..provide preliminary evidence of the validity of a new tool to measure wound healing (the Healing Progression Rate [HPR]), a modified version of the Pressure Ulcer Scale for Healing (PUSH)...
  78. Li Y, Sun Y, Yang G, Hu K, Lv P, Li L. Vertical distribution of microbial community and metabolic pathway in a methanogenic propionate degradation bioreactor. Bioresour Technol. 2017;245:1022-1029 pubmed publisher
    ..The results demonstrated that the maximum organic loading rate (OLR) of the reactor was 2.5g propionic acid (HPr) L-1d-1 with approximately 1...
  79. Kukula K, Klopotowski M, Waś J, Wróbel A, Jamiolkowski J, Debski A, et al. Factors related to on-treatment platelet aggregation assessed by multiple electrode aggregometry in percutaneous coronary intervention patients on clopidogrel and aspirin. Postepy Kardiol Interwencyjnej. 2017;13:210-217 pubmed publisher
    ..Patients at risk of high on-treatment platelet aggregation (HPR) may benefit most from such monitoring.
  80. Kadier A, Kalil M, Chandrasekhar K, Mohanakrishna G, Saratale G, Saratale R, et al. Surpassing the current limitations of high purity H2 production in microbial electrolysis cell (MECs): Strategies for inhibiting growth of methanogens. Bioelectrochemistry. 2018;119:211-219 pubmed publisher
    ..in MECs, which has led to a drop of H2 production efficiency, H2 production rate (HPR) and also a low percentage of H2 in the produced biogas...
  81. Tornyos A, Aradi D, Horvath I, Kónyi A, Magyari B, Pintér T, et al. Clinical outcomes in patients treated for coronary in-stent restenosis with drug-eluting balloons: Impact of high platelet reactivity. PLoS ONE. 2017;12:e0188493 pubmed publisher
    The impact of high platelet reactivity (HPR) on clinical outcomes after elective percutaneous coronary interventions (PCI) with drug-eluting balloons (DEB) due to in-stent restenosis (ISR) is unknown.
  82. But S, Egorova S, Khmelenina V, Trotsenko Y. Biochemical Properties and Phylogeny of Hydroxypyruvate Reductases from Methanotrophic Bacteria with Different C1-Assimilation Pathways. Biochemistry (Mosc). 2017;82:1295-1303 pubmed publisher
    ..capsulatus Bath, and Methylosinus trichosporium OB3b, the biochemical properties of hydroxypyruvate reductase (Hpr), an indicator enzyme of the serine pathway for assimilation of reduced C1-compounds, were comparatively ..
  83. Christoffersen C, Nielsen L, Axler O, Andersson A, Johnsen A, Dahlback B. Isolation and characterization of human apolipoprotein M-containing lipoproteins. J Lipid Res. 2006;47:1833-43 pubmed
    ..Nevertheless, apoM designates a subpopulation of HDL that protects LDL against oxidation and stimulates cholesterol efflux more efficiently than HDL lacking apoM. ..
  84. Widener J, Nielsen M, Shiflett A, Moestrup S, HAJDUK S. Hemoglobin is a co-factor of human trypanosome lytic factor. PLoS Pathog. 2007;3:1250-61 pubmed
    ..Two primate-specific plasma proteins, haptoglobin-related protein (Hpr) and apolipoprotein L-1 (ApoL-1), have been proposed to kill T. b...
  85. Harrington J, Howell S, Hajduk S. Membrane permeabilization by trypanosome lytic factor, a cytolytic human high density lipoprotein. J Biol Chem. 2009;284:13505-12 pubmed publisher
    ..the membrane binding and permeabilizing activity of TLF and its protein constituents, haptoglobin-related protein (Hpr), apolipoprotein L-1 (apoL-1), and apolipoprotein A-1 (apoA-1)...
  86. Kieft R, Capewell P, Turner C, Veitch N, MacLeod A, HAJDUK S. Mechanism of Trypanosoma brucei gambiense (group 1) resistance to human trypanosome lytic factor. Proc Natl Acad Sci U S A. 2010;107:16137-41 pubmed publisher
    ..We propose that the combination of coding sequence mutations and decreased expression of TbgHpHbR directly contribute to parasite evasion of human innate immunity and infectivity of group 1 T. b. gambiense. ..
  87. Cooper J, Reynolds C, Cho H, Kang M. Clinical development of fenretinide as an antineoplastic drug: Pharmacology perspectives. Exp Biol Med (Maywood). 2017;242:1178-1184 pubmed publisher
    Fenretinide (4-HPR) is a synthetic retinoid that has cytotoxic activity against cancer cells...
  88. Kuliczkowski W, Radomski M, GÄ…sior M, Urbaniak J, Kaczmarski J, Mysiak A, et al. MMP-2, MMP-9, and TIMP-4 and Response to Aspirin in Diabetic and Nondiabetic Patients with Stable Coronary Artery Disease: A Pilot Study. Biomed Res Int. 2017;2017:9352015 pubmed publisher
    High on-aspirin treatment platelets reactivity (HPR) is a significant problem in long-term secondary prevention of cardiovascular events. We hypothesize that imbalance between platelets MMPs/TIMPs results in cardiovascular disorders...
  89. Tilemann L, Mohr S, Preusch M, Chorianopoulos E, Giannitsis E, Katus H, et al. Platelet function monitoring for stent thrombosis in critically III patients with an acute Coronary syndrome. J Interv Cardiol. 2017;: pubmed publisher
    ..High post-interventional platelet reactivity (HPR) might be an additional risk factor for ST in these critically ill patients.
  90. Bensi G, Raugei G, Klefenz H, Cortese R. Structure and expression of the human haptoglobin locus. EMBO J. 1985;4:119-26 pubmed
    Human genomic clones of the haptoglobin Hp1F and the "haptoglobin related' gene (Hpr) have been isolated. The two genes are adjacent, spanning a region of approximately 21 kb...
  91. Tabak S, Lev A, Valansi C, Aker O, Shalitin C. Transcriptionally active haptoglobin-related (Hpr) gene in hepatoma G2 and leukemia molt-4 cells. DNA Cell Biol. 1996;15:1001-7 pubmed
    The aim of the present study was to answer the question: Is the haptoglobin-related (Hpr) gene expressed in tumor cells? Our strategy of cloning the cDNA was to screen a human hepatoma G2 cDNA expression library in lambda gt11 using ..
  92. Boyne J, Colgan K, Whitehouse A. Recruitment of the complete hTREX complex is required for Kaposi's sarcoma-associated herpesvirus intronless mRNA nuclear export and virus replication. PLoS Pathog. 2008;4:e1000194 pubmed publisher
    ..Together, these data provide the first direct evidence that the complete hTREX complex is essential for the export of KSHV intronless mRNAs and infectious virus production. ..