HPGDS

Summary

Gene Symbol: HPGDS
Description: hematopoietic prostaglandin D synthase
Alias: GSTS, GSTS1, GSTS1-1, PGD2, PGDS, hematopoietic prostaglandin D synthase, GST class-sigma, glutathione S-transferase sigma, glutathione-dependent PGD synthase, glutathione-dependent PGD synthetase, glutathione-requiring prostaglandin D synthase, hematopoietic prostaglandin D2 synthase, prostaglandin-H2 D-isomerase
Species: human
Products:     HPGDS

Top Publications

  1. Kanaoka Y, Urade Y. Hematopoietic prostaglandin D synthase. Prostaglandins Leukot Essent Fatty Acids. 2003;69:163-7 pubmed
    ..Hematopoietic PGD synthase (H-PGDS) is a cytosolic enzyme that isomerizes PGH(2), a common precursor for all PGs and thromboxanes, to PGD(2) in a ..
  2. Kanaoka Y, Fujimori K, Kikuno R, Sakaguchi Y, Urade Y, Hayaishi O. Structure and chromosomal localization of human and mouse genes for hematopoietic prostaglandin D synthase. Conservation of the ancestral genomic structure of sigma-class glutathione S-transferase. Eur J Biochem. 2000;267:3315-22 pubmed
    b>Hematopoietic prostaglandin D synthase (H-PGDS) is the key enzyme for the production of the D and J series of prostanoids, and the first recognized vertebrate homolog of sigma-class glutathione S-transferase (GST)...
  3. Fujimori K, Kanaoka Y, Sakaguchi Y, Urade Y. Transcriptional activation of the human hematopoietic prostaglandin D synthase gene in megakaryoblastic cells. Roles of the oct-1 element in the 5'-flanking region and the AP-2 element in the untranslated exon 1. J Biol Chem. 2000;275:40511-6 pubmed
    The human hematopoietic prostaglandin D synthase (H-PGDS) gene is highly expressed in human megakaryoblastic cells, in which phorbol ester induces its expression...
  4. Jowsey I, Thomson A, Flanagan J, Murdock P, Moore G, Meyer D, et al. Mammalian class Sigma glutathione S-transferases: catalytic properties and tissue-specific expression of human and rat GSH-dependent prostaglandin D2 synthases. Biochem J. 2001;359:507-16 pubmed
    ..Complementary DNA clones encoding the orthologous human and rat GSH-dependent PGDS (hPGDS and rPGDS, respectively) have been expressed in Escherichia coli, and the recombinant proteins isolated by ..
  5. Bridges P, Jeoung M, Shim S, Park J, Lee J, Sapsford L, et al. Hematopoetic prostaglandin D synthase: an ESR1-dependent oviductal epithelial cell synthase. Endocrinology. 2012;153:1925-35 pubmed publisher
    ..of a hypothesized regulator of oviductal inflammation, the hematopoietic form of prostaglandin D synthase (HPGDS). Immunohistochemistry revealed specific localization of HPGDS to the oviduct's epithelium...
  6. Corwin C, Nikolopoulou A, Pan A, Nunez Santos M, Vallabhajosula S, Serrano P, et al. Prostaglandin D2/J2 signaling pathway in a rat model of neuroinflammation displaying progressive parkinsonian-like pathology: potential novel therapeutic targets. J Neuroinflammation. 2018;15:272 pubmed publisher
    ..we determined in rats the impact of unilateral nigral PGJ2-microinfusions on COX-2, lipocalin-type PGD2 synthase (L-PGDS), PGD2/J2 receptor 2 (DP2), and 15 hydroxyprostaglandin dehydrogenase (15-PGDH)...
  7. Robciuc A, Witos J, Ruokonen S, Rantamäki A, Pisella P, Wiedmer S, et al. Pure Glaucoma Drugs Are Toxic to Immortalized Human Corneal Epithelial Cells, but They Do Not Destabilize Lipid Membranes. Cornea. 2017;36:1249-1255 pubmed publisher
    Most pure glaucoma drugs (pGDs) are hydrophobic substances intended to reduce elevated intraocular pressure...
  8. Redensek A, Rathore K, Berard J, Lopez Vales R, Swayne L, Bennett S, et al. Expression and detrimental role of hematopoietic prostaglandin D synthase in spinal cord contusion injury. Glia. 2011;59:603-14 pubmed publisher
    ..We show here, with the use of hematopoietic prostaglandin D synthase (HPGDS) deficient mice and a HPGDS selective inhibitor (HQL-79), that PGD(2) plays a detrimental ..
  9. Sekeroglu A, Jacobsen J, Jansen Olesen I, Gupta S, Sheykhzade M, Olesen J, et al. Effect of PGD2 on middle meningeal artery and mRNA expression profile of L-PGD2 synthase and DP receptors in trigeminovascular system and other pain processing structures in rat brain. Pharmacol Rep. 2017;69:50-56 pubmed publisher
    ..studied the relative mRNA expression of PGD2 receptors and lipocalin-type of PGD2 synthase (L-PGDS)...

More Information

Publications99

  1. Venara A, Duchalais E, Dariel A, Aubert P, Durand T, Meurette G, et al. Anti-inflammatory Effects of Enhanced Recovery Programs on Early-Stage Colorectal Cancer Surgery. World J Surg. 2018;42:953-964 pubmed publisher
    ..ERP reduced colonic mucosal COX-2, microsomal prostaglandin E synthase (mPGES1) and hematopoietic prostaglandin D synthase (HPGDS) mRNA expression...
  2. Trimarco A, Forese M, Alfieri V, Lucente A, Brambilla P, Dina G, et al. Prostaglandin D2 synthase/GPR44: a signaling axis in PNS myelination. Nat Neurosci. 2014;17:1682-92 pubmed publisher
    ..We found that the intracellular domain of neuregulin 1 type III upregulated the prostaglandin D2 synthase (L-pgds, also known as Ptgds) gene, which, together with the G protein-coupled receptor Gpr44, forms a previously unknown ..
  3. Kim K, Sadikot R, Xiao L, Christman J, Freeman M, Chan J, et al. Nrf2 is essential for the expression of lipocalin-prostaglandin D synthase induced by prostaglandin D2. Free Radic Biol Med. 2013;65:1134-1142 pubmed publisher
    ..Here, we report that Nrf2 uses lipocalin-prostaglandin D synthase (L-PGDS) as a mechanism for suppressing inflammation...
  4. Werder R, Lynch J, Simpson J, Zhang V, Hodge N, Poh M, et al. PGD2/DP2 receptor activation promotes severe viral bronchiolitis by suppressing IFN-λ production. Sci Transl Med. 2018;10: pubmed publisher
    ..We show that RSV infection up-regulated hematopoietic prostaglandin D synthase expression and increased PGD2 release by cultured human primary airway epithelial cells (AECs)...
  5. Mazari A, Hegazy U, Mannervik B. Identification of new inhibitors for human hematopoietic prostaglandin D2 synthase among FDA-approved drugs and other compounds. Chem Biol Interact. 2015;229:91-9 pubmed publisher
    b>Hematopoietic prostaglandin D2 synthase (HPGDS) is a member of the Sigma class glutathione transferases (GSTs) catalyzing the isomerization of prostaglandin H2 to prostaglandin D2, a mediator of allergy and inflammation responses...
  6. Duncan J, Cutress D, Morphew R, Brophy P. Purification of native Sigma class glutathione transferase from Fasciola hepatica. Mol Biochem Parasitol. 2018;222:45-50 pubmed publisher
    ..A recombinant form of Sigma class glutathione transferase (Hematopoietic Prostaglandin D synthase) from F...
  7. Munkholm K, Peijs L, Kessing L, Vinberg M. Reduced mRNA expression of PTGDS in peripheral blood mononuclear cells of rapid-cycling bipolar disorder patients compared with healthy control subjects. Int J Neuropsychopharmacol. 2014;18: pubmed publisher
    ..are the prostaglandin D synthase (PTGDS), which catalyzes the conversion of prostaglandin H2 to prostaglandin D2 (PGD2), and the aldo-keto reductase family 1 member C3 (AKR1C3), which catalyzes the reduction of PGD2...
  8. Tippin B, Kwong A, Inadomi M, Lee O, Park J, Materi A, et al. Intestinal tumor suppression in ApcMin/+ mice by prostaglandin D2 receptor PTGDR. Cancer Med. 2014;3:1041-51 pubmed publisher
    Our earlier work showed that knockout of hematopoietic prostaglandin D synthase (HPGDS, an enzyme that produces prostaglandin D2) caused more adenomas in Apc(Min/+) mice. Conversely, highly expressed transgenic HPGDS allowed fewer tumors...
  9. Vaz R, Li Y, Munson M, Elliot M, Thurairatnam S. Amelioration of mechanism-based inactivation of CYP3A4 by a H-PGDS inhibitor. Bioorg Med Chem Lett. 2018;28:3046-3049 pubmed publisher
    ..amelioration of mechanism-based inactivation (MBI) of Cytochrome P450 (CYP) 3A4 in a human hematopoietic prostaglandin D synthase (hH-PGDS) inhibitor (cpd 1)...
  10. Allegra M, D Acquisto F, Tesoriere L, Attanzio A, Livrea M. Pro-oxidant activity of indicaxanthin from Opuntia ficus indica modulates arachidonate metabolism and prostaglandin synthesis through lipid peroxide production in LPS-stimulated RAW 264.7 macrophages. Redox Biol. 2014;2:892-900 pubmed publisher
    ..NF-κB) and over-expression of PGE2 synthase-1 (mPGES-1), but up-regulated cyclo-oxygenase-2 (COX-2) and PGD2 synthase (H-PGDS), with final production of the anti-inflammatory cyclopentenone...
  11. Kaushik M, Aritake K, Cherasse Y, Sharma R, Urade Y. A gain-of-function study of amelioration of pentylenetetrazole-induced seizures by endogenous prostaglandin D2. Neurosci Lett. 2018;686:140-144 pubmed publisher
    We previously showed that knockout mice of hematopoietic prostaglandin (PG) D synthase (H-PGDS) produce less PGD2 to exacerbate pentylenetetrazole (PTZ)-induced seizures...
  12. Jung S, Kim W, Park S, Jeong J, Park M, Lim S, et al. Two ginseng UDP-glycosyltransferases synthesize ginsenoside Rg3 and Rd. Plant Cell Physiol. 2014;55:2177-88 pubmed publisher
    ..Introduction of the two UGT genes into yeast together with PgDS and PgPPDS resulted in the de novo production of Rg3...
  13. Mizoguchi M, Nakatsuji M, Inoue H, Yamaguchi K, Sakamoto A, Wada K, et al. Novel oral formulation approach for poorly water-soluble drug using lipocalin-type prostaglandin D synthase. Eur J Pharm Sci. 2015;74:77-85 pubmed publisher
    Lipocalin-type prostaglandin D synthase (L-PGDS), a member of the lipocalin superfamily, possesses the function of forming complexes together with various small lipophilic molecules...
  14. Moniot B, Farhat A, Aritake K, Declosmenil F, Nef S, Eguchi N, et al. Hematopoietic prostaglandin D synthase (H-Pgds) is expressed in the early embryonic gonad and participates to the initial nuclear translocation of the SOX9 protein. Dev Dyn. 2011;240:2335-43 pubmed publisher
    ..Sox9 gene expression and SOX9 protein subcellular localization through lipocalin prostaglandin D synthase (L-Pgds) activity...
  15. Kumar S, Palaia T, Hall C, Ragolia L. Role of Lipocalin-type prostaglandin D2 synthase (L-PGDS) and its metabolite, prostaglandin D2, in preterm birth. Prostaglandins Other Lipid Mediat. 2015;118-119:28-33 pubmed publisher
    ..the role of prostaglandin D2 during pregnancy and its mediator Lipocalin-type prostaglandin D2 synthase (L-PGDS) as a predictor of preterm birth (PTB)...
  16. Kwong A, Tippin B, Materi A, Buslon V, French S, Lin H. High dietary niacin may increase prostaglandin formation but does not increase tumor formation in ApcMin/+ mice. Nutr Cancer. 2011;63:950-9 pubmed publisher
    ..whereas PGD(2) may have an opposite effect, on the basis of our report showing that transgenic hematopoietic prostaglandin D synthase suppresses intestinal adenomas in Apc(Min/+) mice...
  17. Takaya D, Inaka K, Omura A, Takenuki K, Kawanishi M, Yabuki Y, et al. Characterization of crystal water molecules in a high-affinity inhibitor and hematopoietic prostaglandin D synthase complex by interaction energy studies. Bioorg Med Chem. 2018;26:4726-4734 pubmed publisher
    b>Hematopoietic prostaglandin D synthase (H-PGDS) is one of the two enzymes that catalyze prostaglandin D2 synthesis and a potential therapeutic target of allergic and inflammatory responses...
  18. Liu M, Eguchi N, Yamasaki Y, Urade Y, Hattori N, Urabe T. Protective role of hematopoietic prostaglandin D synthase in transient focal cerebral ischemia in mice. Neuroscience. 2009;163:296-307 pubmed publisher
    ..Recent studies showed marked induction of hematopoietic prostaglandin D synthase (HPGDS) after ischemic/reperfusion injury and its localization in microglia, but the molecular ..
  19. Seo M, Oh D. Prostaglandin synthases: Molecular characterization and involvement in prostaglandin biosynthesis. Prog Lipid Res. 2017;66:50-68 pubmed publisher
    ..PG synthases, including prostaglandin H synthase (PGHS), 15-hydroxyprostaglandin dehydrogenase (15-HPGD), PGES, PGDS, PGFS, PGIS, and thromboxane A synthase (TXAS)...
  20. Murakami Y, Takahashi K, Hoshi K, Ito H, Kanno M, Saito K, et al. Spontaneous intracranial hypotension is diagnosed by a combination of lipocalin-type prostaglandin D synthase and brain-type transferrin in cerebrospinal fluid. Biochim Biophys Acta Gen Subj. 2018;1862:1835-1842 pubmed publisher
    ..showed significant increase of brain-derived CSF glycoproteins such as lipocalin-type prostaglandin D synthase (L-PGDS), soluble protein fragments generated from amyloid precursor protein (sAPP) and "brain-type" transferrin (Tf)...
  21. Di Muzio E, Polticelli F, di Masi A, Fanali G, Fasano M, Ascenzi P. All-trans-retinoic acid and retinol binding to the FA1 site of human serum albumin competitively inhibits heme-Fe(III) association. Arch Biochem Biophys. 2016;590:56-63 pubmed publisher
    ..Present results may be relevant in vivo, in fact HSA could act as a secondary carrier of retinoids in human diseases associated with reduced levels of RBP4 and IRBP. ..
  22. Moniot B, Ujjan S, Champagne J, Hirai H, Aritake K, Nagata K, et al. Prostaglandin D2 acts through the Dp2 receptor to influence male germ cell differentiation in the foetal mouse testis. Development. 2014;141:3561-71 pubmed publisher
    ..Here, using in vitro and in vivo approaches, we show that prostaglandin D2 (PGD2), which is produced through both L-Pgds and H-Pgds enzymatic activities in the somatic and germ cell compartments of the foetal testis, plays a role in ..
  23. Kuga D, Ushida K, Mii S, Enomoto A, Asai N, Nagino M, et al. Tyrosine Phosphorylation of an Actin-Binding Protein Girdin Specifically Marks Tuft Cells in Human and Mouse Gut. J Histochem Cytochem. 2017;65:347-366 pubmed publisher
    ..of intestines was performed with pY1798 and known TC-markers, for example, hematopoietic-prostaglandin-D-synthase (HPGDS), or doublecortin-like kinase 1 (DCLK1)...
  24. Wang L, Wang N, Mi D, Luo Y, Guo J. Poly-?-glutamic acid productivity of Bacillus subtilis BsE1 has positive function in motility and biocontrol against Fusarium graminearum. J Microbiol. 2017;55:554-560 pubmed publisher
    ..08% (wild type BsE1) to 14.22% in greenhouse experiment against Fusarium root rot. The knockout of pgdS and ggt (genes relate to two ?-PGA degrading enzymes) on BsE1, leads to a considerable improvement in polymer yield ..
  25. Lim W, Bae S, Jo G, Bazer F, Choi Y, Song G. Prostaglandin Dâ‚‚ synthase related to estrogen in the female reproductive tract. Biochem Biophys Res Commun. 2015;456:355-60 pubmed publisher
    ..These results provide the first evidence that PTGDS is a novel estrogen-stimulated gene in oviductal epithelial cells, as well as a candidate biomarker for diagnosis of ovarian carcinoma. ..
  26. Choi Y, Lee S, Aoyagi H, Yamasaki Y, Yoo J, Park B, et al. The extracellular signal-regulated kinase mitogen-activated protein kinase/ribosomal S6 protein kinase 1 cascade phosphorylates cAMP response element-binding protein to induce MUC5B gene expression via D-prostanoid receptor signaling. J Biol Chem. 2011;286:34199-214 pubmed publisher
    ..mediators, including prostaglandin (PG) D(2,) an inflammatory mediator synthesized by hematopoietic PGD synthase (H-PGDS)...
  27. Isensee J, Wenzel C, Buschow R, Weissmann R, Kuss A, Hucho T. Subgroup-elimination transcriptomics identifies signaling proteins that define subclasses of TRPV1-positive neurons and a novel paracrine circuit. PLoS ONE. 2014;9:e115731 pubmed publisher
    ..Analysis of one such signaling system showed that the pain sensitizing prostaglandin PGD2 activates DP1 receptors expressed predominantly on TRPV1(+) neurons...
  28. Waheed M, Ghoneim I, Alhaider A. Seminal plasma and serum fertility biomarkers in dromedary camels (Camelus dromedarius). Theriogenology. 2015;83:650-4 pubmed publisher
    ..Serum malonialdehyde, insulinlike growth factor 1, and clusterin are negatively correlated with fertility of male dromedary camels. ..
  29. White C, Ghazan Shahi S, Adams M. β-Trace protein: a marker of GFR and other biological pathways. Am J Kidney Dis. 2015;65:131-46 pubmed publisher
    ..BTP catalyzes the conversion of prostaglandin H2 (PGH2) to PGD2. PGD2 is an eicosanoid involved in a variety of important physiologic processes, including platelet aggregation, ..
  30. Shan L, Chai W, Lu S, Song Y, Su D, Yang S, et al. The significant effect of chronic intermittent hypoxia on prostaglandin D2 biosynthesis in rat brain. Biochem Biophys Res Commun. 2017;483:283-287 pubmed publisher
    ..Lipocalin-type prostaglandin synthase (L-PGDS) is potentially responsible for the production of prostaglandin D2 (PGD2) which is an ..
  31. Nakajima M, Miyajima M, Ogino I, Akiba C, Sugano H, Hara T, et al. Cerebrospinal fluid biomarkers for prognosis of long-term cognitive treatment outcomes in patients with idiopathic normal pressure hydrocephalus. J Neurol Sci. 2015;357:88-95 pubmed publisher
    ..amyloid β (Aβ)1-38, Aβ1-42 and phosphorylated tau (p-tau), lipocalin-type prostaglandin D synthase (L-PGDS)/β-trace, and cystatin C. The results clearly showed that p-tau levels (sensitivity of 71.4%, specificity of 77...
  32. Fajt M, Gelhaus S, Freeman B, Uvalle C, Trudeau J, Holguin F, et al. Prostaglandin Dâ‚‚ pathway upregulation: relation to asthma severity, control, and TH2 inflammation. J Allergy Clin Immunol. 2013;131:1504-12 pubmed publisher
    ..PGDâ‚‚, which is generated by hematopoietic prostaglandin D synthase (HPGDS), acts on 3 G protein-coupled receptors, including chemoattractant receptor-homologous ..
  33. Caballero Solares A, Hall J, Xue X, Eslamloo K, Taylor R, Parrish C, et al. The dietary replacement of marine ingredients by terrestrial animal and plant alternatives modulates the antiviral immune response of Atlantic salmon (Salmo salar). Fish Shellfish Immunol. 2017;64:24-38 pubmed publisher
    ..mxb, and gig1) and the lowest levels of transcripts encoding eicosanoid-synthesizing enzymes (5loxa, 5loxb, and pgds)...
  34. Qin S, Shimamoto S, Maruno T, Kobayashi Y, Kawahara K, Yoshida T, et al. Thermodynamic and NMR analyses of NADPH binding to lipocalin-type prostaglandin D synthase. Biochem Biophys Res Commun. 2015;468:234-9 pubmed publisher
    ..is one of the most abundant proteins in human cerebrospinal fluid (CSF) with dual functions as a prostaglandin D2 (PGD2) synthase and a transporter of lipophilic ligands...
  35. Li X, Zhang Y, Zhang B, Liu X, Hong L, Liu L, et al. HIF-1?-l-PGDS-PPAR? regulates hypoxia-induced ANP secretion in beating rat atria. Prostaglandins Other Lipid Mediat. 2017;134:38-46 pubmed publisher
    Lipocalin-type prostaglandin D synthase (L-PGDS) and peroxisome proliferator activated receptor ? (PPAR?) play important roles in cardiovascular diseases...
  36. Edfeldt F, Evenäs J, Lepistö M, Ward A, Petersen J, Wissler L, et al. Identification of indole inhibitors of human hematopoietic prostaglandin D2 synthase (hH-PGDS). Bioorg Med Chem Lett. 2015;25:2496-500 pubmed publisher
    Human H-PGDS has shown promise as a potential target for anti-allergic and anti-inflammatory drugs...
  37. Kumar S, Lau R, Hall C, Palaia T, Brathwaite C, Ragolia L. Bile acid elevation after Roux-en-Y gastric bypass is associated with cardio-protective effect in Zucker Diabetic Fatty rats. Int J Surg. 2015;24:70-4 pubmed publisher
    Roux-en-Y gastric bypass (RYGB) may improve cardiometabolic risk through alteration of bile acids and L-PGDS levels...
  38. Tsutsumi S, Ogino I, Miyajima M, Ito M, Arai H, Yasumoto Y. Cerebrospinal fluid drainage through the diploic and spinal epidural veins. J Anat. 2015;227:297-301 pubmed publisher
    ..epidural veins as cerebrospinal fluid (CSF) drainage pathways by measuring lipocalin-type prostaglandin D synthase (PGDS) and cystatin C (CysC) dissolved in the blood of these veins...
  39. Gupta R, Yadav A, Misra R, Aggarwal A. Urinary prostaglandin D synthase as biomarker in lupus nephritis: a longitudinal study. Clin Exp Rheumatol. 2015;33:694-8 pubmed
    ..Given that uPGDS levels fall after treatment of LN, uPGDS may be used to monitor the efficacy of therapy. It can also differentiate patients with active nephritis and active non renal lupus. ..
  40. Asirvatham Jeyaraj N, Fink G. Possible role for brain prostanoid pathways in the development of angiotensin II-salt hypertension in rats. Am J Physiol Regul Integr Comp Physiol. 2016;311:R232-42 pubmed publisher
  41. Mitson Salazar A, Yin Y, Wansley D, Young M, Bolan H, Arceo S, et al. Hematopoietic prostaglandin D synthase defines a proeosinophilic pathogenic effector human T(H)2 cell subpopulation with enhanced function. J Allergy Clin Immunol. 2016;137:907-18.e9 pubmed publisher
    ..as chemoattractant receptor-homologous molecule expressed on T(H)2 cells-positive (CRTH2(+)), hematopoietic prostaglandin D synthase-positive CD161(hi) CD4 T cells...
  42. Kida T, Ayabe S, Omori K, Nakamura T, Maehara T, Aritake K, et al. Prostaglandin D2 Attenuates Bleomycin-Induced Lung Inflammation and Pulmonary Fibrosis. PLoS ONE. 2016;11:e0167729 pubmed publisher
    ..Here, we investigated whether genetic disruption of hematopoietic PGD synthase (H-PGDS) affects the bleomycin-induced lung inflammation and pulmonary fibrosis in mouse...
  43. Le Loupp A, Bach Ngohou K, Bourreille A, Boudin H, Rolli Derkinderen M, Denis M, et al. Activation of the prostaglandin D2 metabolic pathway in Crohn's disease: involvement of the enteric nervous system. BMC Gastroenterol. 2015;15:112 pubmed publisher
    ..the ability of the ENS to secrete PGD2 in proinflammatory conditions, Lipocalin-type prostaglandin D synthase (L-PGDS) expression by neurons and glial cells was analyzed by immunostaining...
  44. Kumar S, Lau R, Hall C, Palaia T, Rideout D, Brathwaite C, et al. Lipocalin-type prostaglandin D2 synthase (L-PGDS) modulates beneficial metabolic effects of vertical sleeve gastrectomy. Surg Obes Relat Dis. 2016;12:1523-1531 pubmed publisher
    ..The objective of this study was to investigate the role of lipocalin-type prostaglandin D2 synthase (L-PGDS) in glucose regulation in response to VSG using L-PGDS knock-out (KO), knock-in (KI), and C57BL/6 (wild type) mice...
  45. Nakamura T, Maeda S, Horiguchi K, Maehara T, Aritake K, Choi B, et al. PGD2 deficiency exacerbates food antigen-induced mast cell hyperplasia. Nat Commun. 2015;6:7514 pubmed publisher
    ..Systemic gene deficiency of haematopoietic PGD synthase (H-PGDS(-/-)) exacerbates all of the manifestations accompanying severe mast cell hyperplasia in the intestine...
  46. Morell Garcia D, Bauça J, Sastre M, Yáñez A, Llompart I. Sample-dependent diagnostic accuracy of prostaglandin D synthase in cerebrospinal fluid leak. Clin Biochem. 2017;50:27-31 pubmed publisher
    ..The cut off value for ?TP in the diagnosis and follow-up of cerebrospinal fluid leaks should be modified depending on the type of secretion (sample type), for a better diagnostic accuracy. ..
  47. Finch E, Kudva A, Quickel M, Goodfield L, Kennett M, Whelan J, et al. Chemopreventive Effects of Dietary Eicosapentaenoic Acid Supplementation in Experimental Myeloid Leukemia. Cancer Prev Res (Phila). 2015;8:989-99 pubmed publisher
    ..Inhibition of hematopoietic-prostaglandin D synthase (H-PGDS) by HQL-79 in EPA-supplemented CML mice also blocked the effect of EPA...
  48. Peyre M, Salaud C, Clermont Taranchon E, Niwa Kawakita M, Goutagny S, Mawrin C, et al. PDGF activation in PGDS-positive arachnoid cells induces meningioma formation in mice promoting tumor progression in combination with Nf2 and Cdkn2ab loss. Oncotarget. 2015;6:32713-22 pubmed publisher
    ..In vitro, PDGF-B overexpression in PGDS-positive arachnoid cells lead to increased proliferation...
  49. Feng J, Gu Y, Quan Y, Cao M, Gao W, Zhang W, et al. Improved poly-γ-glutamic acid production in Bacillus amyloliquefaciens by modular pathway engineering. Metab Eng. 2015;32:106-115 pubmed publisher
    ..8 to 4.15 g/L. The γ-PGA degrading genes pgdS (encoding poly-gamma-glutamate depolymerase) and cwlO (encoding cell wall hydrolase) were further deleted...
  50. Abboud R, Akil M, Charcosset C, Greige Gerges H. Interaction of glucocorticoids and progesterone derivatives with human serum albumin. Chem Phys Lipids. 2017;207:271-278 pubmed publisher
    Glucocorticoids (GCs) and progesterone derivatives (PGDs) are steroid hormones with well-known biological activities. Their interaction with human serum albumin (HSA) may control their distribution...
  51. Zhang L, Ma J, Jin X, Jia G, Jiang Y, Li C. L-PGDS Mediates Vagus Nerve Stimulation-Induced Neuroprotection in a Rat Model of Ischemic Stroke by Suppressing the Apoptotic Response. Neurochem Res. 2017;42:644-655 pubmed publisher
    The role of lipocalin prostaglandin D2 synthase (L-PGDS) in brain ischemia has not been fully clarified to date...
  52. Hsieh L, Shieh J, Wei L, Wang Y, Cheng K, Shih C. Polymer gel dosimeters for pretreatment radiotherapy verification using the three-dimensional gamma evaluation and pass rate maps. Phys Med. 2017;37:75-81 pubmed publisher
    Polymer gel dosimeters (PGDs) have been widely studied for use in the pretreatment verification of clinical radiation therapy. However, the readability of PGDs in three-dimensional (3D) dosimetry remain unclear...
  53. Gómez Abellán V, Montero J, López Muñoz A, Figueras A, Arizcun M, Mulero V, et al. Professional phagocytic granulocyte-derived PGD2 regulates the resolution of inflammation in fish. Dev Comp Immunol. 2015;52:182-91 pubmed publisher
    ..PGD(2) can be either pro- or anti-inflammatory depending on the inflammatory milieu. Prostaglandin D synthase (PGDS) is the enzyme responsible for the conversion of PGH(2) to PGD(2)...
  54. Ishii T. Close teamwork between Nrf2 and peroxiredoxins 1 and 6 for the regulation of prostaglandin D2 and E2 production in macrophages in acute inflammation. Free Radic Biol Med. 2015;88:189-198 pubmed publisher
    ..Prx6, leading to NADPH oxidase-2 activation, which contributes to production of PGD2 by hematopoietic prostaglandin D synthase (H-PGDS)...
  55. Bae Y, Kim J, Kong Y. Phylogenetic characterization of Clonorchis sinensis proteins homologous to the sigma-class glutathione transferase and their differential expression profiles. Mol Biochem Parasitol. 2016;206:46-55 pubmed publisher
    ..b>GSTs are classified into multiple classes on the basis of their primary structures and substrate/inhibitor specificity...
  56. Feng X, Ramsden M, Negri J, Baker M, Payne S, Borish L, et al. Eosinophil production of prostaglandin D2 in patients with aspirin-exacerbated respiratory disease. J Allergy Clin Immunol. 2016;138:1089-1097.e3 pubmed publisher
    ..mRNA was extracted and evaluated for expression of hematopoietic prostaglandin D synthase (hPGDS)...
  57. Brunner H, Bennett M, Gulati G, Abulaban K, Klein Gitelman M, Ardoin S, et al. Urine Biomarkers to Predict Response to Lupus Nephritis Therapy in Children and Young Adults. J Rheumatol. 2017;44:1239-1248 pubmed publisher
    ..If confirmed, these results can be used to help personalize LN therapy. ..
  58. Smith E, Jorgensen A, Midgley A, Oni L, Goilav B, Putterman C, et al. International validation of a urinary biomarker panel for identification of active lupus nephritis in children. Pediatr Nephrol. 2017;32:283-295 pubmed publisher
    ..991). In two international JSLE cohorts, urinary AGP, ceruloplasmin, LPGDS and TF demonstrate an 'excellent' ability for accurately identifying active LN in children. ..
  59. Chung C, Kanetsky P, Wang Z, Hildebrandt M, Koster R, Skotheim R, et al. Meta-analysis identifies four new loci associated with testicular germ cell tumor. Nat Genet. 2013;45:680-5 pubmed publisher
    ..2 in HPGDS (per-allele odds ratio (OR) = 1.19, 95% confidence interval (CI) = 1.12-1.26; P = 1.11 × 10(-8)), 7p22...
  60. Tsutsumi S, Ogino I, Miyajima M, Nonaka S, Ito M, Yasumoto Y, et al. Role of cathepsin K in the development of chronic subdural hematoma. J Clin Neurosci. 2017;45:343-347 pubmed publisher
    ..CatK, lipocalin-type prostaglandin D synthase (PGDS), and cystatin C (CysC) present in these specimens were measured using enzyme-linked immunosorbent assay...
  61. Inoue T, Okano Y, Kado Y, Aritake K, Irikura D, Uodome N, et al. First determination of the inhibitor complex structure of human hematopoietic prostaglandin D synthase. J Biochem. 2004;135:279-83 pubmed
    Hematopoietic prostaglandin (PG) D synthase (H-PGDS) is responsible for the production of PGD(2) as an allergy or inflammation mediator in mast and Th2 cells...
  62. Tumani H, Huss A, Bachhuber F. The cerebrospinal fluid and barriers - anatomic and physiologic considerations. Handb Clin Neurol. 2017;146:21-32 pubmed publisher
    ..Alterations of lumbar CSF are mainly influenced by processes of the CNS located adjacent to the ventricular and spinal CSF space and less by pathologies in cortical areas remote from the ventricles. ..
  63. Hsueh Y, Huang K, Kunene S, Lee T. Poly-?-glutamic Acid Synthesis, Gene Regulation, Phylogenetic Relationships, and Role in Fermentation. Int J Mol Sci. 2017;18: pubmed publisher
    ..and the phylogenetic relationships among various pgsBCAE, a biosynthesis gene cluster of ?-PGA, and pgdS, a degradation gene of ?-PGA...
  64. Abraham J, Harrington P, Driver K, Tyrer J, Easton D, Dunning A, et al. Common polymorphisms in the prostaglandin pathway genes and their association with breast cancer susceptibility and survival. Clin Cancer Res. 2009;15:2181-91 pubmed publisher
    ..05) in PTGS1, PTGS2, TBXAS1, PTGIS, PTGES, PTGDS, and PGDS with a two-stage case-control study design...
  65. Sui D, Wilson J. Interaction of insulin-like growth factor binding protein-4, Miz-1, leptin, lipocalin-type prostaglandin D synthase, and granulin precursor with the N-terminal half of type III hexokinase. Arch Biochem Biophys. 2000;382:262-74 pubmed
    ..Cotransfection with leptin or Miz-1 resulted in distinctly different localization of the HKIII-GFP fusion protein, at intracellular sites coincident with localization of leptin-GFP or Miz-1-GFP reporter constructs. ..
  66. Portioli C, Bovi M, Benati D, Donini M, Perduca M, Romeo A, et al. Novel functionalization strategies of polymeric nanoparticles as carriers for brain medications. J Biomed Mater Res A. 2017;105:847-858 pubmed publisher
    ..E modified peptide (pep-apoE) responsible for LDLR binding, or with lipocalin-type prostaglandin-d-synthase (L-PGDS), highly expressed in the brain...
  67. Hamsten C, Häggmark A, Grundström J, Mikus M, Lindskog C, Konradsen J, et al. Protein profiles of CCL5, HPGDS, and NPSR1 in plasma reveal association with childhood asthma. Allergy. 2016;71:1357-61 pubmed publisher
    ..After screening, chemokine ligand 5 (CCL5) hematopoietic prostaglandin D synthase (HPGDS) and neuropeptide S receptor 1 (NPSR1) were selected for further investigation...
  68. Joo M, Kwon M, Cho Y, Hu N, Pedchenko T, Sadikot R, et al. Lipopolysaccharide-dependent interaction between PU.1 and c-Jun determines production of lipocalin-type prostaglandin D synthase and prostaglandin D2 in macrophages. Am J Physiol Lung Cell Mol Physiol. 2009;296:L771-9 pubmed publisher
    Previously, we reported that expression of lipocalin-prostaglandin D synthase (L-PGDS) is inducible in macrophages and protects from Pseudomonas pneumonia...
  69. Hohwy M, Spadola L, Lundquist B, Hawtin P, Dahmén J, Groth Clausen I, et al. Novel prostaglandin D synthase inhibitors generated by fragment-based drug design. J Med Chem. 2008;51:2178-86 pubmed publisher
    We describe the discovery of novel inhibitors of prostaglandin D2 synthase (PGDS) through fragment-based lead generation and structure-based drug design...
  70. Suzuki T, Watanabe K, Kanaoka Y, Sato T, Hayaishi O. Induction of hematopoietic prostaglandin D synthase in human megakaryocytic cells by phorbol ester. Biochem Biophys Res Commun. 1997;241:288-93 pubmed
    ..These results suggest that hematopoietic PGD synthase is a useful marker for identifying the differentiation stage of human megakaryocytes. ..
  71. Pinzar E, Kanaoka Y, Inui T, Eguchi N, Urade Y, Hayaishi O. Prostaglandin D synthase gene is involved in the regulation of non-rapid eye movement sleep. Proc Natl Acad Sci U S A. 2000;97:4903-7 pubmed
    To examine the function of prostaglandin (PG) D synthase (PGDS) gene, as well as endogenously produced PGD(2) in sleep regulation in vivo, we generated transgenic (TG) mice that overexpress human PGDS gene to study their sleep behavior...
  72. Inoue T, Irikura D, Okazaki N, Kinugasa S, Matsumura H, Uodome N, et al. Mechanism of metal activation of human hematopoietic prostaglandin D synthase. Nat Struct Biol. 2003;10:291-6 pubmed
    ..Using GSH as a cofactor, prostaglandin D synthase catalyzes the isomerization of PGH2 to PGD2, a mediator for allergy response...
  73. Ando M, Murakami Y, Kojima F, Endo H, Kitasato H, Hashimoto A, et al. Retrovirally introduced prostaglandin D2 synthase suppresses lung injury induced by bleomycin. Am J Respir Cell Mol Biol. 2003;28:582-91 pubmed
    b>Hematopoietic prostaglandin D synthase (PGDS) is a key enzyme to produce prostaglandin (PG) D and J series. These PGs are involved in inflammation and immune system...
  74. Tippin B, Levine A, Materi A, Song W, Keku T, Goodman J, et al. Hematopoietic prostaglandin D synthase (HPGDS): a high stability, Val187Ile isoenzyme common among African Americans and its relationship to risk for colorectal cancer. Prostaglandins Other Lipid Mediat. 2012;97:22-8 pubmed publisher
    Intestinal tumors in Apc(Min/+) mice are suppressed by over-production of HPGDS, which is a glutathione transferase that forms prostaglandin D(2) (PGD(2))...
  75. Liu B, Yang J, Luo W, Zhang Y, Li J, Li H, et al. Prostaglandin D2 is the major cyclooxygenase-1-derived product in prepartum mouse uteri where it mediates an enhanced in vitro myometrial contraction. Eur J Pharmacol. 2017;813:140-146 pubmed publisher
    ..Western blot or real-time PCR revealed that expressions of COX-1 and PGD2 synthase (PGDS) in prepartum uteri were higher than those of non-pregnant mice, while both were diminished by the removal of ..
  76. Oguma T, Asano K, Ishizaka A. Role of prostaglandin D(2) and its receptors in the pathophysiology of asthma. Allergol Int. 2008;57:307-12 pubmed publisher
  77. Kado Y, Aritake K, Uodome N, Okano Y, Okazaki N, Matsumura H, et al. Human hematopoietic prostaglandin D synthase inhibitor complex structures. J Biochem. 2012;151:447-55 pubmed publisher
    In mast and Th2 cells, hematopoietic prostaglandin (PG) D synthase (H-PGDS) catalyses the isomerization of PGH(2) in the presence of glutathione (GSH) to produce the allergic and inflammatory mediator PGD(2)...
  78. Mizoguchi M, Nakatsuji M, Takano J, Ishibashi O, Wada K, Inui T. Development of pH-Independent Drug Release Formulation Using Lipocalin-Type Prostaglandin D Synthase. J Pharm Sci. 2016;105:2735-2742 pubmed publisher
    ..These results, taken together, demonstrate that the use of this well-designed drug-delivery carrier is feasible for the development of pH-independent drug release formulations. ..
  79. Mahmud I, Ueda N, Yamaguchi H, Yamashita R, Yamamoto S, Kanaoka Y, et al. Prostaglandin D synthase in human megakaryoblastic cells. J Biol Chem. 1997;272:28263-6 pubmed
    The cytosol fraction of human platelets did not convert prostaglandin (PG) H2 to PGD2. However, a homogenate of human megakaryoblastic CMK cells (precursor cells of platelets) produced PGD2 from PGH2...
  80. Uchida Y, Urade Y, Mori S, Kohzuma T. UV resonance Raman studies on the activation mechanism of human hematopoietic prostaglandin D(2) synthase by a divalent cation, Mg(2+). J Inorg Biochem. 2010;104:331-40 pubmed publisher
    ..ion-assisted activation mechanism of the active site Tyr8 of a human hematopoietic prostaglandin D(2) synthase (H-PGDS) was studied by ultraviolet resonance Raman (UVRR) spectroscopy. Addition of Mg(2+) to the native H-PGDS at pH 8...
  81. Omori K, Morikawa T, Kunita A, Nakamura T, Aritake K, Urade Y, et al. Lipocalin-type prostaglandin D synthase-derived PGD2 attenuates malignant properties of tumor endothelial cells. J Pathol. 2018;244:84-96 pubmed publisher
    ..Here, we found a marked increase in lipocalin-type prostaglandin D synthase (L-PGDS) mRNA (Ptgds) expression in ECs isolated from mouse melanoma...
  82. Sugioka K, Saito A, Kusaka S, Kuniyoshi K, Shimomura Y. Identification of vitreous proteins in retinopathy of prematurity. Biochem Biophys Res Commun. 2017;488:483-488 pubmed publisher
    ..The proteins specific to or decreased in ROP, if confirmed in future studies, may provide clue to understanding its pathogenesis. ..
  83. Yamamoto K, Higashiura A, Suzuki M, Aritake K, Urade Y, Nakagawa A. Molecular structure of a prostaglandin D synthase requiring glutathione from the brown planthopper, Nilaparvata lugens. Biochem Biophys Res Commun. 2017;492:166-171 pubmed publisher
    ..Specifically, prostaglandin D synthase (PGDS) catalyzes the isomerization of PGH2 to PGD2...
  84. Moyo R, Chimponda T, Mukanganyama S. Inhibition of hematopoietic prostaglandin D2 synthase (H-PGDS) by an alkaloid extract from Combretum molle. BMC Complement Altern Med. 2014;14:221 pubmed publisher
    b>Hematopoietic prostaglandin D2 synthase (H-PGDS, GST Sigma) is a member of the glutathione S-transferase super family of enzymes that catalyses the conjugation of electrophilic substances with reduced glutathione...
  85. Meleza C, Thomasson B, Ramachandran C, O Neill J, Michelsen K, Lo M. Development of a scintillation proximity binding assay for high-throughput screening of hematopoietic prostaglandin D2 synthase. Anal Biochem. 2016;511:17-23 pubmed publisher
    ..PGD2 produced by hematopoietic prostaglandin D2 synthase (H-PGDS) in mast cells and Th2 cells is proposed to be a mediator of allergic and inflammatory ..
  86. Welter H, Köhn F, Mayerhofer A. Mast cells in human testicular biopsies from patients with mixed atrophy: increased numbers, heterogeneity, and expression of cyclooxygenase 2 and prostaglandin D2 synthase. Fertil Steril. 2011;96:309-13 pubmed publisher
    ..MCs) and to examine the expression of key enzymes of prostaglandin (PG) synthesis, cyclooxygenase 2 (COX2), and PGD2 synthase in the testes of men with mixed atrophy (MA) syndrome and in normal samples. Retrospective study...
  87. Maeda S, Nakamura T, Harada H, Tachibana Y, Aritake K, Shimosawa T, et al. Prostaglandin D2 metabolite in urine is an index of food allergy. Sci Rep. 2017;7:17687 pubmed publisher
    ..presented with increased numbers of intestinal mast cells, which strongly expressed hematopoietic PGD synthase (H-PGDS). The levels of urinary tetranor-PGDM increased as the disease progressed...
  88. Yazaki M, Kashiwagi K, Aritake K, Urade Y, Fujimori K. Rapid degradation of cyclooxygenase-1 and hematopoietic prostaglandin D synthase through ubiquitin-proteasome system in response to intracellular calcium level. Mol Biol Cell. 2012;23:12-21 pubmed publisher
    Cyclooxygenase (COX)-1 and hematopoietic prostaglandin (PG) D synthase (H-PGDS) proteins, which are both involved in the arachidonate cascade, were stable in human megakaryocytic MEG-01 cells...
  89. Noguchi E, Shibasaki M, Kamioka M, Yokouchi Y, Yamakawa Kobayashi K, Hamaguchi H, et al. New polymorphisms of haematopoietic prostaglandin D synthase and human prostanoid DP receptor genes. Clin Exp Allergy. 2002;32:93-6 pubmed
    ..there are any mutations associated with the development of asthma in the haematopoietic prostaglandin D synthase (H-PGDS) gene and the human prostanoid DP receptor (PTGDR) gene...
  90. Tokugawa Y, Kunishige I, Kubota Y, Shimoya K, Nobunaga T, Kimura T, et al. Lipocalin-type prostaglandin D synthase in human male reproductive organs and seminal plasma. Biol Reprod. 1998;58:600-7 pubmed
    Prostaglandin D synthase (PGDS) activity was detected in human seminal plasma (0.05-1.83 nmol/min per milligram protein)...