HDAC5

Summary

Gene Symbol: HDAC5
Description: histone deacetylase 5
Alias: HD5, NY-CO-9, histone deacetylase 5, antigen NY-CO-9
Species: human
Products:     HDAC5

Top Publications

  1. Jin Y, Jeon E, Li Q, Lee Y, Choi J, Kim W, et al. Transforming growth factor-beta stimulates p300-dependent RUNX3 acetylation, which inhibits ubiquitination-mediated degradation. J Biol Chem. 2004;279:29409-17 pubmed
    ..Our findings demonstrate that the level of RUNX3 protein is controlled by the competitive acetylation and deacetylation of the three lysine residues, revealing a new mechanism for the posttranslational regulation of RUNX3 expression. ..
  2. Spiegelberg B, Hamm H. G betagamma binds histone deacetylase 5 (HDAC5) and inhibits its transcriptional co-repression activity. J Biol Chem. 2005;280:41769-76 pubmed
    ..effectors of the G betagamma subunit of heterotrimeric G proteins, we found that G betagamma binds to histone deacetylase 5 (HDAC5), an enzyme involved in a pathway not previously recognized to be directly impacted by G proteins...
  3. Fischle W, Dequiedt F, Hendzel M, Guenther M, Lazar M, Voelter W, et al. Enzymatic activity associated with class II HDACs is dependent on a multiprotein complex containing HDAC3 and SMRT/N-CoR. Mol Cell. 2002;9:45-57 pubmed
    ..These observations indicate that class II HDACs regulate transcription by bridging the enzymatically active SMRT/N-CoR-HDAC3 complex and select transcription factors independently of any intrinsic HDAC activity. ..
  4. Martini J, Raake P, Vinge L, DeGeorge B, DeGeorge B, Chuprun J, et al. Uncovering G protein-coupled receptor kinase-5 as a histone deacetylase kinase in the nucleus of cardiomyocytes. Proc Natl Acad Sci U S A. 2008;105:12457-62 pubmed publisher
    ..deacetylase (HDAC) kinase because it can associate with and phosphorylate the myocyte enhancer factor-2 repressor, HDAC5. Moreover, significant HDAC activity can be found with GRK5 in the heart...
  5. Peixoto P, Castronovo V, Matheus N, Polese C, Peulen O, Gonzalez A, et al. HDAC5 is required for maintenance of pericentric heterochromatin, and controls cell-cycle progression and survival of human cancer cells. Cell Death Differ. 2012;19:1239-52 pubmed publisher
    ..In this study, we further investigated the biological function of HDAC5 in cancer cells...
  6. McKinsey T, Zhang C, Lu J, Olson E. Signal-dependent nuclear export of a histone deacetylase regulates muscle differentiation. Nature. 2000;408:106-11 pubmed
    ..MEF2 proteins also interact with the class II histone deacetylases HDAC4 and HDAC5, resulting in repression of MEF2-dependent genes...
  7. Choi S, Piao Z, Jin L, Kim J, Kim G, Ryu Y, et al. Piceatannol Attenuates Renal Fibrosis Induced by Unilateral Ureteral Obstruction via Downregulation of Histone Deacetylase 4/5 or p38-MAPK Signaling. PLoS ONE. 2016;11:e0167340 pubmed publisher
    ..HDAC1, HDAC4, HDAC5, HDAC6, and HDAC10 protein expression was upregulated in UUO kidneys, whereas that of HDAC8 was downregulated...
  8. Salminen A, Kauppinen A, Kaarniranta K. AMPK/Snf1 signaling regulates histone acetylation: Impact on gene expression and epigenetic functions. Cell Signal. 2016;28:887-95 pubmed publisher
    ..Moreover, nuclear AMPK can phosphorylate type 2A histone deacetylases (HDAC), e.g. HDAC4 and HDAC5, triggering their export from nuclei thus promoting histone acetylation reactions...
  9. Ciccarelli M, Vastolo V, Albano L, Lecce M, Cabaro S, Liotti A, et al. Glucose-induced expression of the homeotic transcription factor Prep1 is associated with histone post-translational modifications in skeletal muscle. Diabetologia. 2016;59:176-86 pubmed publisher
    ..L6 cells, Prep1-induced recruitment of the repressor complex myocyte enhancer factor 2 (MEF2)/histone deacetylase 5 (HDAC5) at the Glut4 promoter was also increased, leading to reduced Glut4 expression...

More Information

Publications131 found, 100 shown here

  1. van Zoelen E, Duarte I, Hendriks J, van der Woning S. TGF?-induced switch from adipogenic to osteogenic differentiation of human mesenchymal stem cells: identification of drug targets for prevention of fat cell differentiation. Stem Cell Res Ther. 2016;7:123 pubmed publisher
    ..Gene expression and immunoblot analysis indicated that IBMX-induced suppression of HDAC5 levels plays an important role in the inhibitory effect of TGF? on osteogenic differentiation...
  2. Valdez B, Li Y, Murray D, Ji J, Liu Y, Popat U, et al. Comparison of the cytotoxicity of cladribine and clofarabine when combined with fludarabine and busulfan in AML cells: Enhancement of cytotoxicity with epigenetic modulators. Exp Hematol. 2015;43:448-61.e2 pubmed publisher
    ..of proliferation; activation of the ATM pathway; increase in histone modifications; decrease in HDAC3, HDAC4, HDAC5 and SirT7 proteins; decrease in mitochondrial membrane potential; activation of apoptosis and stress signaling ..
  3. Kumar S, Jahangir Alam M, Prabhakar P, Ahmad S, Maulik S, Sharma M, et al. Proteomic analysis of the protective effects of aqueous bark extract of Terminalia arjuna (Roxb.) on isoproterenol-induced cardiac hypertrophy in rats. J Ethnopharmacol. 2017;198:98-108 pubmed publisher
    ..Survival kinase Akt, ER stress marker Grp78 and epigenetic regulator HDAC5 were augmented by ISO and TA restored them by various extents...
  4. Novak J, Fabrik I, Linhartova I, Link M, Cerny O, Stulik J, et al. Phosphoproteomics of cAMP signaling of Bordetella adenylate cyclase toxin in mouse dendritic cells. Sci Rep. 2017;7:16298 pubmed publisher
    ..PRAS40 and altered phosphorylation of multiple chromatin remodelers, including the class II histone deacetylase HDAC5. CyaA toxin action further elicited inhibitory phosphorylation of SIK family kinases involved in modulation of ..
  5. Su C, Su C, Hsiao Y, Gean P. Epigenetic regulation of BDNF in the learned helplessness-induced animal model of depression. J Psychiatr Res. 2016;76:101-10 pubmed publisher
    ..The expression of HDAC5 was up-regulated in the LH mice, and a ChIP assay revealed that the level of HDAC5 binding to the promoter region ..
  6. Raghunathan S, Goyal R, Patel B. Selective inhibition of HDAC2 by magnesium valproate attenuates cardiac hypertrophy. Can J Physiol Pharmacol. 2017;95:260-267 pubmed publisher
    ..e., HDAC2) without altering the expression of anti-hypertrophic HDAC5. Selective class I HDAC inhibition is required for controlling cardiac hypertrophy...
  7. Kim J, Hwangbo C, Hu X, Kang Y, Papangeli I, Mehrotra D, et al. Restoration of impaired endothelial myocyte enhancer factor 2 function rescues pulmonary arterial hypertension. Circulation. 2015;131:190-9 pubmed publisher
    ..nuclear accumulation of 2 class IIa histone deacetylases (HDACs) that inhibit its function, namely HDAC4 and HDAC5. Selective, pharmacological inhibition of class IIa HDACs led to restoration of MEF2 activity in PAECs, as ..
  8. Lee G, Joo J, Choi B, Lindroth A, Park S, Park Y. Neuroprotective effects of Paeonia Lactiflora extract against cell death of dopaminergic SH-SY5Y cells is mediated by epigenetic modulation. BMC Complement Altern Med. 2016;16:208 pubmed publisher
    ..PLE pretreatment impeded the changes in H3K9ac and H3K27ac, coincided with increased expression of HDAC5 without changes in HAT expression...
  9. Siuda D, Tobias S, Rus A, Xia N, Förstermann U, Li H. Dexamethasone upregulates Nox1 expression in vascular smooth muscle cells. Pharmacology. 2014;94:13-20 pubmed publisher
    ..of these 4 individual HDAC enzymes did not prevent the effect of dexamethasone on Nox1 expression, although HDAC5 knockdown markedly reduced basal Nox1 expression...
  10. Oda T, Yamamoto T, Kato T, Uchinoumi H, Fukui G, Hamada Y, et al. Nuclear translocation of calmodulin in pathological cardiac hypertrophy originates from ryanodine receptor bound calmodulin. J Mol Cell Cardiol. 2018;: pubmed publisher
    ..Suramin also promoted GRK5 nuclear import, and caused nuclear export of histone deacetylase 5 (HDAC5). Dantrolene prevented these effects...
  11. Kain V, Kapadia B, Viswakarma N, Seshadri S, Prajapati B, Jena P, et al. Co-activator binding protein PIMT mediates TNF-α induced insulin resistance in skeletal muscle via the transcriptional down-regulation of MEF2A and GLUT4. Sci Rep. 2015;5:15197 pubmed publisher
    ..Mechanistic analysis revealed that PIMT differentially regulated the expression of GLUT4, MEF2A, PGC-1α and HDAC5 in cultured cells and skeletal muscle of Wistar rats...
  12. Patel B. Sodium Butyrate Controls Cardiac Hypertrophy in Experimental Models of Rats. Cardiovasc Toxicol. 2018;18:1-8 pubmed publisher
    ..e., HDAC2, without altering the expression of anti-hypertrophic HDAC5. Sodium butyrate produces beneficial effect on cardiac hypertrophy as is evident, specifically from reduction in ..
  13. Panach L, Serna E, Tarin J, Cano A, García Pérez M. A translational approach from an animal model identifies CD80 as a candidate gene for the study of bone phenotypes in postmenopausal women. Osteoporos Int. 2017;28:2445-2455 pubmed publisher
    ..bone mineral density (BMD) (nominal P values), while adjusting for confounders, for SNPs in the CD80, CD86, and HDAC5 genes...
  14. Islam M, Große Brinkhaus C, Pröll M, Uddin M, Rony S, Tesfaye D, et al. Deciphering transcriptome profiles of peripheral blood mononuclear cells in response to PRRSV vaccination in pigs. BMC Genomics. 2016;17:641 pubmed publisher
    ..Network enrichment analysis revealed APP, TRAF6, PIN1, FOS, CTNNB1, TNFAIP3, TIP1, CDKN1, SIRT1, ESR1 and HDAC5 as the highly interconnected hubs of the functional network of PRRSV vaccine induced transcriptome changes in ..
  15. He K, Hu J, Yu H, Wang L, Tang F, Gu J, et al. Serine/Threonine Kinase 40 (Stk40) Functions as a Novel Regulator of Skeletal Muscle Differentiation. J Biol Chem. 2017;292:351-360 pubmed publisher
    ..Mechanistically, Stk40 controls the protein level of histone deacetylase 5 (HDAC5) to maintain transcriptional activities of myocyte enhancer factor 2 (MEF2), a family of ..
  16. Ling H, Zhang T, Pereira L, Means C, Cheng H, Gu Y, et al. Requirement for Ca2+/calmodulin-dependent kinase II in the transition from pressure overload-induced cardiac hypertrophy to heart failure in mice. J Clin Invest. 2009;119:1230-40 pubmed publisher
    ..KO mice, transverse aortic constriction (TAC) induced comparable increases in relative heart weight, cell size, HDAC5 phosphorylation, and hypertrophic gene expression...
  17. Holly M, Smith J. Adenovirus infection of human enteroids reveals interferon sensitivity and preferential infection of goblet cells. J Virol. 2018;: pubmed publisher
    ..And, HAdV-5p but not HAdV-41p was potently neutralized by the enteric human alpha-defensin HD5. These studies highlight new facets of HAdV biology that are uniquely revealed by primary intestinal epithelial ..
  18. Funato H, Oda S, Yokofujita J, Igarashi H, Kuroda M. Fasting and high-fat diet alter histone deacetylase expression in the medial hypothalamus. PLoS ONE. 2011;6:e18950 pubmed publisher
    ..Four weeks on a high-fat diet resulted in the increased expression of HDAC5 and -8...
  19. Dole N, Delany A. MicroRNA variants as genetic determinants of bone mass. Bone. 2016;84:57-68 pubmed publisher
    ..bone morphogenetic protein receptor 1 (Bmpr1), fibroblast growth factor 2 (Fgf2), osteonectin (Sparc) and histone deacetylase 5 (Hdac5)...
  20. Hsing C, Hung S, Chen Y, Wei T, Sun D, Wang J, et al. Histone Deacetylase Inhibitor Trichostatin A Ameliorated Endotoxin-Induced Neuroinflammation and Cognitive Dysfunction. Mediators Inflamm. 2015;2015:163140 pubmed publisher
    ..Moreover, mRNA expression of HDAC2, HDAC5, indoleamine 2,3-dioxygenase (IDO), TNF-α, MCP-1, and IL-1β in the brain of LPS-challenged mice and in the ..
  21. Dudakovic A, Gluscevic M, Paradise C, Dudakovic H, Khani F, Thaler R, et al. Profiling of human epigenetic regulators using a semi-automated real-time qPCR platform validated by next generation sequencing. Gene. 2017;609:28-37 pubmed publisher
    ..g., HDAC5 and HDAC7)...
  22. Erburu M, Cajaleon L, Guruceaga E, Venzala E, Muñoz Cobo I, Beltrán E, et al. Chronic mild stress and imipramine treatment elicit opposite changes in behavior and in gene expression in the mouse prefrontal cortex. Pharmacol Biochem Behav. 2015;135:227-36 pubmed publisher
    ..Of these, some changes of the circadian rhythm pathway (Hdac5, Per1, and Per2) were validated by RT-PCR and western-blot...
  23. Liu Z, Chen D, Jiang R, Chen Y, Xiong W, Wang F, et al. [Ginsenoside Rh?-induced inhibition of histone deacetylase 6 promotes K562 cells autophagy and apoptosis in vivo]. Zhongguo Zhong Yao Za Zhi. 2016;41:700-704 pubmed publisher
    ..HDAC in tumor tissues were detected by chemical colorimetry assay, and expressions of HDAC1, HDAC2, HDAC3, HDAC4, HDAC5 and HDAC6 were detected by Western blotting assay...
  24. Tokarz D, Cisek R, Wein M, Turcotte R, Haase C, Yeh S, et al. Intravital imaging of osteocytes in mouse calvaria using third harmonic generation microscopy. PLoS ONE. 2017;12:e0186846 pubmed publisher
    ..to study structural variations in the LCN of live mice deficient in both histone deacetylase 4 and 5 (HDAC4, HDAC5)...
  25. Chen J, Wang N, Dong M, Guo M, Zhao Y, Zhuo Z, et al. The Metabolic Regulator Histone Deacetylase 9 Contributes to Glucose Homeostasis Abnormality Induced by Hepatitis C Virus Infection. Diabetes. 2015;64:4088-98 pubmed publisher
    Class IIa histone deacetylases (HDACs), such as HDAC4, HDAC5, and HDAC7, provide critical mechanisms for regulating glucose homeostasis...
  26. Wehkamp J, Wang G, Kübler I, Nuding S, Gregorieff A, Schnabel A, et al. The Paneth cell alpha-defensin deficiency of ileal Crohn's disease is linked to Wnt/Tcf-4. J Immunol. 2007;179:3109-18 pubmed
    ..Within specimens, the levels of Tcf-4 mRNA showed a high degree of correlation with both HD5 and HD6 mRNA...
  27. Gomis Coloma C, Velasco Aviles S, Gomez Sanchez J, Casillas Bajo A, Backs J, Cabedo H. Class IIa histone deacetylases link cAMP signaling to the myelin transcriptional program of Schwann cells. J Cell Biol. 2018;217:1249-1268 pubmed publisher
    ..Using conditional knockout mice, we also show that HDAC4 together with HDAC5 redundantly contribute to activate the myelin transcriptional program and the development of myelin sheath in vivo...
  28. Kaletsch A, Pinkerneil M, Hoffmann M, Jaguva Vasudevan A, Wang C, Hansen F, et al. Effects of novel HDAC inhibitors on urothelial carcinoma cells. Clin Epigenetics. 2018;10:100 pubmed publisher
    ..In most cell lines, 19i as well as SAHA induced HDAC5 and HDAC4 mRNAs while rather repressing HDAC7...
  29. Waltregny D, North B, Van Mellaert F, de Leval J, Verdin E, Castronovo V. Screening of histone deacetylases (HDAC) expression in human prostate cancer reveals distinct class I HDAC profiles between epithelial and stromal cells. Eur J Histochem. 2004;48:273-90 pubmed
    ..b>HDAC5, a class II HDAC involved in myogenesis, was not detected in the tissues...
  30. Ye M, Fang Z, Gu H, Song R, Ye J, Li H, et al. Histone deacetylase 5 promotes the migration and invasion of hepatocellular carcinoma via increasing the transcription of hypoxia-inducible factor-1? under hypoxia condition. Tumour Biol. 2017;39:1010428317705034 pubmed publisher
    ..We found that histone deacetylase 5, a highly expressed histone deacetylase in hepatocellular carcinoma, strengthened the migration and ..
  31. McKinsey T, Zhang C, Olson E. Identification of a signal-responsive nuclear export sequence in class II histone deacetylases. Mol Cell Biol. 2001;21:6312-21 pubmed
    ..Nucleocytoplasmic trafficking of HDAC5 is mediated by binding of the chaperone protein 14-3-3 to two phosphoserine residues (Ser-259 and Ser-498) in its ..
  32. Zhang C, McKinsey T, Olson E. Association of class II histone deacetylases with heterochromatin protein 1: potential role for histone methylation in control of muscle differentiation. Mol Cell Biol. 2002;22:7302-12 pubmed
    ..Here we report that MITR, HDAC4, and HDAC5 associate with heterochromatin protein 1 (HP1), an adaptor protein that recognizes methylated lysines within ..
  33. Castet A, Boulahtouf A, Versini G, Bonnet S, Augereau P, Vignon F, et al. Multiple domains of the Receptor-Interacting Protein 140 contribute to transcription inhibition. Nucleic Acids Res. 2004;32:1957-66 pubmed
    ..demonstrate that RIP140 associates in vitro not only with class I HDACs but also with class II enzymes such as HDAC5. This interaction mainly involves the N-terminus of RIP140 (residues 27-199) and two domains of HDAC5...
  34. Vega R, Harrison B, Meadows E, Roberts C, Papst P, Olson E, et al. Protein kinases C and D mediate agonist-dependent cardiac hypertrophy through nuclear export of histone deacetylase 5. Mol Cell Biol. 2004;24:8374-85 pubmed
    ..by protein kinase C (PKC) is sufficient and, in some cases, necessary to drive nuclear export of class II HDAC5 in cardiomyocytes...
  35. Deng X, Ewton D, Mercer S, Friedman E. Mirk/dyrk1B decreases the nuclear accumulation of class II histone deacetylases during skeletal muscle differentiation. J Biol Chem. 2005;280:4894-905 pubmed
    ..MEF2 is sequestered by class II HDACs such as HDAC5 and MEF2-interacting transcriptional repressor (MITR)...
  36. Bossuyt J, Helmstadter K, Wu X, Clements Jewery H, Haworth R, Avkiran M, et al. Ca2+/calmodulin-dependent protein kinase IIdelta and protein kinase D overexpression reinforce the histone deacetylase 5 redistribution in heart failure. Circ Res. 2008;102:695-702 pubmed publisher
    ..HF) are associated with reactivation of fetal cardiac genes, and class II histone deacetylases (HDACs) (eg, HDAC5) have been strongly implicated in this process...
  37. Perlis R, Moorjani P, Fagerness J, Purcell S, Trivedi M, Fava M, et al. Pharmacogenetic analysis of genes implicated in rodent models of antidepressant response: association of TREK1 and treatment resistance in the STAR(*)D study. Neuropsychopharmacology. 2008;33:2810-9 pubmed publisher
    ..The authors examined variants in four such genes (KCNK2 (TREK1), SLC18A2 (VMAT2), S100A10, and HDAC5) for association with remission in a large effectiveness trial of antidepressant treatments...
  38. Yoshida T, Gan Q, Owens G. Kruppel-like factor 4, Elk-1, and histone deacetylases cooperatively suppress smooth muscle cell differentiation markers in response to oxidized phospholipids. Am J Physiol Cell Physiol. 2008;295:C1175-82 pubmed publisher
    ..at the SM alpha-actin promoter, which was mediated by the recruitment of histone deacetylases (HDACs), HDAC2 and HDAC5. Coimmunoprecipitation assays showed that Klf4 interacted with HDAC5...
  39. Sakao Y, Kato A, Tsuji T, Yasuda H, Togawa A, Fujigaki Y, et al. Cisplatin induces Sirt1 in association with histone deacetylation and increased Werner syndrome protein in the kidney. Clin Exp Nephrol. 2011;15:363-372 pubmed publisher
    ..Sirt1 was induced to a greater extent in rats with severe ARF. In contrast, HDAC3 and HDAC5 were not induced within 24 h after CDDP administration...
  40. Lopez Rodriguez R, Hernández Bartolomé Á, Borque M, Rodríguez Muñoz Y, Martín Vílchez S, Trapero Marugan M, et al. Polymorphisms in histone deacetylases improve the predictive value of IL-28B for chronic hepatitis C therapy. Genes Immun. 2013;14:317-24 pubmed publisher
    ..Three SNPs, rs3778216, rs976552 and rs368328 in HDAC2, HDAC3 and HDAC5, respectively, were independently associated with SVR (P<0.05)...
  41. Fischer S, Paul A, Wagner A, Mathias S, Geiss M, Schandock F, et al. miR-2861 as novel HDAC5 inhibitor in CHO cells enhances productivity while maintaining product quality. Biotechnol Bioeng. 2015;112:2142-53 pubmed publisher
    ..Furthermore, we demonstrate that miR-2861 might post-transcriptionally regulate HDAC5 in CHO cells...
  42. Sun G, Yu R, Evans R, Shi Y. Orphan nuclear receptor TLX recruits histone deacetylases to repress transcription and regulate neural stem cell proliferation. Proc Natl Acad Sci U S A. 2007;104:15282-7 pubmed
    ..TLX interacts with HDAC3 and HDAC5 in neural stem cells...
  43. Sen N, Kumari R, Singh M, Das S. HDAC5, a key component in temporal regulation of p53-mediated transactivation in response to genotoxic stress. Mol Cell. 2013;52:406-20 pubmed publisher
    ..Our data reveal that histone deacetylase 5 (HDAC5) binds to p53 and abrogates K120 acetylation, resulting in preferential recruitment of p53 to ..
  44. Choi M, Lee S, Wang S, Ko S, Song M, Choi J, et al. Ketamine produces antidepressant-like effects through phosphorylation-dependent nuclear export of histone deacetylase 5 (HDAC5) in rats. Proc Natl Acad Sci U S A. 2015;112:15755-60 pubmed publisher
    ..Here, we demonstrate that ketamine rapidly stimulates histone deacetylase 5 (HDAC5) phosphorylation and nuclear export in rat hippocampal neurons through calcium/calmodulin kinase II-..
  45. Kemler D, Dahley O, Roßwag S, Litfin M, Kassel O. The LIM domain protein nTRIP6 acts as a co-repressor for the transcription factor MEF2C in myoblasts. Sci Rep. 2016;6:27746 pubmed publisher
    ..Mechanistically, nTRIP6 mediated the recruitment of the class IIa histone deacetylase HDAC5 to the MEF2C-bound promoters...
  46. Wang C, Zhao G, Wang S, Chen Y, Gong Y, Chen S, et al. A Simplified Derivative of Human Defensin 5 with Potent and Efficient Activity against Multidrug-Resistant Acinetobacter baumannii. Antimicrob Agents Chemother. 2018;62: pubmed publisher
    ..Human defensin 5 (HD5) is an endogenous peptide with a complex architecture and antibacterial activity against MDRAb In the ..
  47. Song K, Backs J, McAnally J, Qi X, Gerard R, Richardson J, et al. The transcriptional coactivator CAMTA2 stimulates cardiac growth by opposing class II histone deacetylases. Cell. 2006;125:453-66 pubmed
    ..are defective in cardiac growth in response to pressure overload and neurohumoral signaling, whereas mice lacking HDAC5, a class II HDAC, are sensitized to the prohypertrophic actions of CAMTA...
  48. Taglieri D, Johnson K, Burmeister B, Monasky M, Spindler M, DeSantiago J, et al. The C-terminus of the long AKAP13 isoform (AKAP-Lbc) is critical for development of compensatory cardiac hypertrophy. J Mol Cell Cardiol. 2014;66:27-40 pubmed publisher
    ..are observed in AKAP-Lbc-ΔPKD mice compared to WT mice, resulting in diminished phosphorylation of histone deacetylase 5 (HDAC5) and decreased hypertrophic gene expression...
  49. Seo M, Ly N, Lee C, Cho H, Choi C, Nhu L, et al. Early life stress increases stress vulnerability through BDNF gene epigenetic changes in the rat hippocampus. Neuropharmacology. 2016;105:388-397 pubmed publisher
    ..Both the MS and RS groups had increased MeCP2 levels at BDNF promoter IV, as well as increased HDAC5 mRNA, and the combination of MS and RS exerted a greater effect on these parameters than did RS alone...
  50. Sun H, Mediwala S, Szafran A, Mancini M, Marcelli M. CUDC-101, a Novel Inhibitor of Full-Length Androgen Receptor (flAR) and Androgen Receptor Variant 7 (AR-V7) Activity: Mechanism of Action and In Vivo Efficacy. Horm Cancer. 2016;7:196-210 pubmed publisher
    ..of CUDC-101 on flAR and AR-V7 was duplicated only by other HDAC inhibitors, or by silencing the HDAC isoforms HDAC5 and HDAC10...
  51. To M, Swallow E, Akashi K, Haruki K, Natanek S, Polkey M, et al. Reduced HDAC2 in skeletal muscle of COPD patients. Respir Res. 2017;18:99 pubmed publisher
    ..42, p = 0.029). HDAC5 protein in muscle biopsies of COPD patients (HDAC5/β-actin: 0.44 ± 0...
  52. Li Z, Qin H, Li J, Yu L, Yang Y, Xu Y. HADC5 deacetylates MKL1 to dampen TNF-? induced pro-inflammatory gene transcription in macrophages. Oncotarget. 2017;8:94235-94246 pubmed publisher
    ..Here we report that the lysine deacetylase HDAC5 interacts with and deacetylates MKL1 in cells...
  53. Lee H, Li F, Choi U, Yu H, Aldrovandi G, Feng P, et al. Deregulation of HDAC5 by Viral Interferon Regulatory Factor 3 Plays an Essential Role in Kaposi's Sarcoma-Associated Herpesvirus-Induced Lymphangiogenesis. MBio. 2018;9: pubmed publisher
    ..Mass spectrometry analysis revealed that vIRF3 interacted with histone deacetylase 5 (HDAC5), which is a signal-responsive regulator for vascular homeostasis...
  54. Huynh K, Fischle W, Verdin E, Bardwell V. BCoR, a novel corepressor involved in BCL-6 repression. Genes Dev. 2000;14:1810-23 pubmed
    ..Additionally, interactions between the BCL-6 POZ domain and SMRT, N-CoR, and BCoR are mutually exclusive. The specificity of the BCL-6/BCoR interaction suggests that BCoR may have a role in BCL-6-associated lymphomas. ..
  55. Chauchereau A, Mathieu M, de Saintignon J, Ferreira R, Pritchard L, Mishal Z, et al. HDAC4 mediates transcriptional repression by the acute promyelocytic leukaemia-associated protein PLZF. Oncogene. 2004;23:8777-84 pubmed
    ..Taken together, our data indicate that recruitment of HDAC4 is necessary for PLZF-mediated repression in both normal and leukaemic cells. ..
  56. Pang J, Yan C, Natarajan K, Cavet M, Massett M, Yin G, et al. GIT1 mediates HDAC5 activation by angiotensin II in vascular smooth muscle cells. Arterioscler Thromb Vasc Biol. 2008;28:892-8 pubmed publisher
    ..Histone deacetylase-5 (HDAC5) has emerged as an important substrate of calcium/calmodulin-dependent protein kinase II (CamK II) in GPCR ..
  57. van Rooij E, Fielitz J, Sutherland L, Thijssen V, Crijns H, Dimaio M, et al. Myocyte enhancer factor 2 and class II histone deacetylases control a gender-specific pathway of cardioprotection mediated by the estrogen receptor. Circ Res. 2010;106:155-65 pubmed publisher
    ..Here we show that the absence of HDAC5 or -9 in female mice protects against maladaptive remodeling following myocardial infarction, during which there ..
  58. Harris L, Wang S, Mani S, Kasiganesan H, Chou C, Menick D. Evidence for a non-canonical role of HDAC5 in regulation of the cardiac Ncx1 and Bnp genes. Nucleic Acids Res. 2016;44:3610-7 pubmed publisher
    ..Here we directly address whether the class IIa HDAC, HDAC5 may function as a scaffold to recruit co-repressor complexes to promoters...
  59. Wein M, Liang Y, Göransson O, Sundberg T, Wang J, Williams E, et al. SIKs control osteocyte responses to parathyroid hormone. Nat Commun. 2016;7:13176 pubmed publisher
    ..Here we show that PTH inhibition of SOST (sclerostin), a WNT antagonist, requires HDAC4 and HDAC5, whereas PTH stimulation of RANKL, a stimulator of bone resorption, requires CRTC2...
  60. Lee Y, Lee J, Jang J, Chi X, Kim J, Li Y, et al. Runx3 inactivation is a crucial early event in the development of lung adenocarcinoma. Cancer Cell. 2013;24:603-16 pubmed publisher
    ..These results provide a missing link between oncogenic K-Ras and the p14(ARF)-p53 pathway, and may explain how cells defend against oncogenic K-Ras. ..
  61. Marroquin Belaunzaran O, Kleber S, Schauer S, Hausmann M, Nicholls F, Van Den Broek M, et al. HLA-B27-Homodimer-Specific Antibody Modulates the Expansion of Pro-Inflammatory T-Cells in HLA-B27 Transgenic Rats. PLoS ONE. 2015;10:e0130811 pubmed publisher
    ..The monoclonal HD5 antibody was selected from a phage library to target cell-surface B272 homodimers and characterized for affinity, ..
  62. Xiao H, Jiao J, Wang L, O Brien S, Newick K, Wang L, et al. HDAC5 controls the functions of Foxp3(+) T-regulatory and CD8(+) T cells. Int J Cancer. 2016;138:2477-86 pubmed publisher
    ..Here, we studied the immune phenotype of HDAC5(-/-) mice on a C57BL/6 background...
  63. Ow J, Palanichamy Kala M, Rao V, Choi M, Bharathy N, Taneja R. G9a inhibits MEF2C activity to control sarcomere assembly. Sci Rep. 2016;6:34163 pubmed publisher
    ..demonstrate that the lysine methyltransferase G9a inhibits sarcomere organization through regulation of the MEF2C-HDAC5 regulatory axis. Sarcomeres are essential for muscle contractile function...
  64. Weber D, Frauenschläger K, Ghimire S, Peter K, Panzer I, Hiergeist A, et al. The association between acute graft-versus-host disease and antimicrobial peptide expression in the gastrointestinal tract after allogeneic stem cell transplantation. PLoS ONE. 2017;12:e0185265 pubmed publisher
    ..001), HD5 (p?0.002) and HD6 (p?0.02)...
  65. Baek S, Ohgi K, Rose D, Koo E, Glass C, Rosenfeld M. Exchange of N-CoR corepressor and Tip60 coactivator complexes links gene expression by NF-kappaB and beta-amyloid precursor protein. Cell. 2002;110:55-67 pubmed
  66. Stewart R, Akhmedov D, Robb C, Leiter C, Berdeaux R. Regulation of SIK1 abundance and stability is critical for myogenesis. Proc Natl Acad Sci U S A. 2013;110:117-22 pubmed publisher
    ..Our findings support an emerging model in which SIK1 integrates cAMP signaling with the myogenic program to support appropriate timing of differentiation. ..
  67. Liu Z, Chen T, Han Q, Chen M, You J, Fang F, et al. HDAC inhibitor LMK?235 promotes the odontoblast differentiation of dental pulp cells. Mol Med Rep. 2017;: pubmed publisher
    ..However, the effects of HDAC4 and HDAC5 on the differentiation of DPCs and the precise molecular mechanisms remain unclear...
  68. Lu J, McKinsey T, Nicol R, Olson E. Signal-dependent activation of the MEF2 transcription factor by dissociation from histone deacetylases. Proc Natl Acad Sci U S A. 2000;97:4070-5 pubmed
  69. Linseman D, Bartley C, Le S, Laessig T, Bouchard R, Meintzer M, et al. Inactivation of the myocyte enhancer factor-2 repressor histone deacetylase-5 by endogenous Ca(2+) //calmodulin-dependent kinase II promotes depolarization-mediated cerebellar granule neuron survival. J Biol Chem. 2003;278:41472-81 pubmed
    ..MEF2 activity and CGN survival are compromised by overexpression of the MEF2 repressor histone deacetylase-5 (HDAC5). Furthermore, removal of depolarization induced rapid cytoplasm-to-nuclear translocation of endogenous HDAC5...
  70. Walkinshaw D, Weist R, Xiao L, Yan K, Kim G, Yang X. Dephosphorylation at a conserved SP motif governs cAMP sensitivity and nuclear localization of class IIa histone deacetylases. J Biol Chem. 2013;288:5591-605 pubmed publisher
    Histone deacetylase 4 (HDAC4) and its paralogs, HDAC5, -7, and -9 (all members of class IIa), possess multiple phosphorylation sites crucial for 14-3-3 binding and subsequent nuclear export...
  71. Han X, Xue L, Gong L, Zhu S, Yao L, Wang S, et al. Stat3 inhibits PTPN13 expression in squamous cell lung carcinoma through recruitment of HDAC5. Biomed Res Int. 2013;2013:468963 pubmed publisher
    ..assays, we show that Stat3 binds to the promoter region of PTPN13 and promotes its activity through recruiting HDAC5. Thus, our results suggest a previously unknown Stat3-PTPN13 molecular network controlling squamous cell lung ..
  72. Dressel U, Bailey P, Wang S, Downes M, Evans R, Muscat G. A dynamic role for HDAC7 in MEF2-mediated muscle differentiation. J Biol Chem. 2001;276:17007-13 pubmed
    ..The nucleocytoplasmic trafficking of HDAC7 and other class-II HDACs during myogenesis provides an ideal mechanism for the regulation of HDAC targets during mammalian development and differentiation. ..
  73. Koipally J, Georgopoulos K. A molecular dissection of the repression circuitry of Ikaros. J Biol Chem. 2002;277:27697-705 pubmed
    ..Finally, we show that, barring CtBP, the Ikaros family members Aiolos, Helios, and Eos can associate with all of the identified corepressors of Ikaros including its newly identified interactors, Class II HDACs. ..
  74. Gomes M, Borges K, Moreno D, Queiroz R, Machado H, Carlotti C, et al. Abnormal methylation of histone deacetylase genes: implications on etiology and epigenetic therapy of astrocytomas. Anticancer Res. 2011;31:1337-43 pubmed
    ..Methylation of the HDAC4, HDAC5 and HDAC6 genes was assessed in 29 tumor samples (astrocytomas grades I, III, and IV) and in the glioblastoma cell ..
  75. Cao C, Vasilatos S, Bhargava R, Fine J, Oesterreich S, Davidson N, et al. Functional interaction of histone deacetylase 5 (HDAC5) and lysine-specific demethylase 1 (LSD1) promotes breast cancer progression. Oncogene. 2017;36:133-145 pubmed publisher
    ..However, the underlying mechanisms are largely unknown. Here, we report that expression of HDAC5 and LSD1 proteins were positively correlated in human breast cancer cell lines and tissue specimens of primary ..
  76. Huang E, Zhang J, Miska E, Guenther M, Kouzarides T, Lazar M. Nuclear receptor corepressors partner with class II histone deacetylases in a Sin3-independent repression pathway. Genes Dev. 2000;14:45-54 pubmed
    ..RD, which is conserved in N-CoR and SMRT, represses transcription by interacting directly with class II HDAC4 and HDAC5. Endogenous N-CoR and SMRT each associate with HDAC4 in a complex that does not contain mSin3A or HDAC1...
  77. Ozawa Y, Towatari M, Tsuzuki S, Hayakawa F, Maeda T, Miyata Y, et al. Histone deacetylase 3 associates with and represses the transcription factor GATA-2. Blood. 2001;98:2116-23 pubmed
    ..Furthermore, GATA-2 also directly associated with HDAC5 but not with other class II HDACs examined, that is, HDAC4 and HDAC6...
  78. Verdin E, Dequiedt F, Kasler H. Class II histone deacetylases: versatile regulators. Trends Genet. 2003;19:286-93 pubmed
    ..We discuss their emerging biological functions and the molecular mechanisms by which they are regulated. ..
  79. Watamoto K, Towatari M, Ozawa Y, Miyata Y, Okamoto M, Abe A, et al. Altered interaction of HDAC5 with GATA-1 during MEL cell differentiation. Oncogene. 2003;22:9176-84 pubmed
    ..interact with GATA-1 to regulate its function and indeed, GATA-1 is directly associated with HDAC3, HDAC4 and HDAC5. The expression profiling and our previous observation that GATA-2 interacts with members of the HDAC family ..
  80. Chen H, Qi L. SUMO modification regulates the transcriptional activity of XBP1. Biochem J. 2010;429:95-102 pubmed publisher
    ..Thus our results reveal an unexpected role for SUMO (small ubiquitin-related modifier) in the regulation of UPR activation and ER homeostasis. ..
  81. Agis Balboa R, Pavelka Z, Kerimoglu C, Fischer A. Loss of HDAC5 impairs memory function: implications for Alzheimer's disease. J Alzheimers Dis. 2013;33:35-44 pubmed publisher
    ..In this study we investigated the role of HDAC5 in memory function and AD pathogenesis...
  82. Grozinger C, Hassig C, Schreiber S. Three proteins define a class of human histone deacetylases related to yeast Hda1p. Proc Natl Acad Sci U S A. 1999;96:4868-73 pubmed
    ..The corresponding full-length cDNAs were cloned and defined as HDAC4, HDAC5, and HDAC6...
  83. Simonsson M, Heldin C, Ericsson J, Grönroos E. The balance between acetylation and deacetylation controls Smad7 stability. J Biol Chem. 2005;280:21797-803 pubmed
  84. Ha C, Kim J, Zhao J, Wang W, Jhun B, Wong C, et al. PKA phosphorylates histone deacetylase 5 and prevents its nuclear export, leading to the inhibition of gene transcription and cardiomyocyte hypertrophy. Proc Natl Acad Sci U S A. 2010;107:15467-72 pubmed publisher
    ..Recent studies have identified several protein kinases that phosphorylate HDAC5, leading to its exportation from the nucleus...
  85. Walkinshaw D, Weist R, Kim G, You L, Xiao L, Nie J, et al. The tumor suppressor kinase LKB1 activates the downstream kinases SIK2 and SIK3 to stimulate nuclear export of class IIa histone deacetylases. J Biol Chem. 2013;288:9345-62 pubmed publisher
  86. Cao X, Liu D, Zhou Y, Yan X, Yuan L, Pan J, et al. Histone deacetylase 5 promotes Wilms' tumor cell proliferation through the upregulation of c-Met. Mol Med Rep. 2016;13:2745-50 pubmed publisher
    ..However, the biological function of HDAC5 in Wilms' tumor remains to be fully elucidated...
  87. Klappacher G, Lunyak V, Sykes D, Sawka Verhelle D, Sage J, Brard G, et al. An induced Ets repressor complex regulates growth arrest during terminal macrophage differentiation. Cell. 2002;109:169-80 pubmed
  88. Greco T, Yu F, Guise A, Cristea I. Nuclear import of histone deacetylase 5 by requisite nuclear localization signal phosphorylation. Mol Cell Proteomics. 2011;10:M110.004317 pubmed publisher
    b>Histone deacetylase 5 (HDAC5), a class IIa deacetylase, is a prominent regulator of cellular and epigenetic processes that underlie the progression of human disease, ranging from cardiac hypertrophy to cancer...
  89. Darlyuk Saadon I, Weidenfeld Baranboim K, Yokoyama K, Hai T, Aronheim A. The bZIP repressor proteins, c-Jun dimerization protein 2 and activating transcription factor 3, recruit multiple HDAC members to the ATF3 promoter. Biochim Biophys Acta. 2012;1819:1142-53 pubmed publisher
    ..ATF3 enhanced transcription is significantly reduced in MEF cells lacking both ATF3 and JDP2. Collectively, we propose that the recruitment of multiple HDAC members to JDP2 and ATF3 is part of their transcription repression mechanism. ..
  90. Qiu X, Li J, Lv S, Yu J, Jiang J, Yao J, et al. HDAC5 integrates ER stress and fasting signals to regulate hepatic fatty acid oxidation. J Lipid Res. 2018;59:330-338 pubmed publisher
    ..Here we show that fasting glucagon stimulates the dephosphorylation and nuclear translocation of histone deacetylase 5 (HDAC5), where it interacts with PPAR? and promotes transcriptional activity of PPAR?...
  91. Wen Y, Perissi V, Staszewski L, Yang W, Krones A, Glass C, et al. The histone deacetylase-3 complex contains nuclear receptor corepressors. Proc Natl Acad Sci U S A. 2000;97:7202-7 pubmed
    ..N-CoR also interacts with class II deacetylases HDAC4, HDAC5, and HDAC7...
  92. Zhang C, McKinsey T, Lu J, Olson E. Association of COOH-terminal-binding protein (CtBP) and MEF2-interacting transcription repressor (MITR) contributes to transcriptional repression of the MEF2 transcription factor. J Biol Chem. 2001;276:35-9 pubmed
    ..These findings reveal CtBP-dependent and -independent mechanisms for transcriptional repression by MITR and show that MITR represses MEF2 activity through recruitment of multicomponent corepressor complexes that include CtBP and HDACs. ..