HARS2

Summary

Gene Symbol: HARS2
Description: histidyl-tRNA synthetase 2, mitochondrial
Alias: HARSL, HARSR, HO3, PRLTS2, HARS-related, hisRS, histidine tRNA ligase 2, mitochondrial (putative), histidine translase, histidine-tRNA ligase homolog, histidyl-tRNA synthetase 2, mitochondrial (putative)
Species: human
Products:     HARS2

Top Publications

  1. Baklanova Y, Lipina O, Enyashin A, Surat L, Tyutyunnik A, Tarakina N, et al. Nd3+,Ho3+-Codoped apatite-related NaLa9(GeO4)6O2 phosphors for the near- and middle-infrared region. Dalton Trans. 2018;: pubmed publisher
    The apatite-like NaLa9(GeO4)6O2:Nd3+,Ho3+ phosphor is prepared using the solid-state method...
  2. Yan L, Zhou B, Song N, Liu X, Huang J, Wang T, et al. Self-sensitization induced upconversion of Er3+ in core-shell nanoparticles. Nanoscale. 2018;10:17949-17957 pubmed publisher
    ..can be further purified and enhanced by mediating the upconversion dynamics through introducing the lanthanides of Ho3+, Tm3+ and Yb3+, which can effectively contribute to the population in the red emitting state...
  3. Zhang Z, Li D, Shi W, Liu Y, Zhang Y, Liu Y, et al. A New Up-conversion Material of Ho3+-Yb3+-Mg2+ Tri-doped TiO2 and Its Applications to Perovskite Solar Cells. Nanoscale Res Lett. 2018;13:262 pubmed publisher
    ..It is demonstrated that the synthesized UC-Mg-TiO2 can convert the near-infrared light to visible light that perovskite film can absorb to improve the power conversion efficiency of the devices. ..
  4. Gibson O, Richardson A, Hayes M, Duncan B, Maxwell N. Prediction of physiological responses and performance at altitude using the 6-minute walk test in normoxia and hypoxia. Wilderness Environ Med. 2015;26:205-10 pubmed publisher
    ..once; and hypoxic outdoor (HO) was performed three times, at 42 hours (HO1), 138 hours (HO2), and 210 hours (HO3) after arrival at Cuzco. One-way analysis of variance revealed no difference (P>...
  5. Gao F, Zhang Y, Sun W, Liu H, Chen X. Syntheses, structures and magnetic properties of macrocyclic Schiff base-supported homodinuclear lanthanide complexes. Dalton Trans. 2018;47:11696-11704 pubmed publisher
    Five new homodinuclear lanthanide complexes with the general formula [(acac)4Ln2(L)] (Ln3+ = Dy3+ (1), Tb3+ (2), Ho3+ (3), Er3+ (4), and Gd (5)) were synthesized by one-pot [2 + 2] condensation of 2,6-diformyl-4-methylphenol and 1,3-..
  6. Demain L, Urquhart J, O SULLIVAN J, Williams S, Bhaskar S, Jenkinson E, et al. Expanding the genotypic spectrum of Perrault syndrome. Clin Genet. 2017;91:302-312 pubmed publisher
    ..Biallelic variants in five genes are reported to be causative: HSD17B4, HARS2, LARS2, CLPP and C10orf2. Here we present eight families affected by Perrault syndrome...
  7. Wang L, Draz M, Wang W, Liao G, Xu Y. The Quality of In Vivo Upconversion Fluorescence Signals Inside Different Anatomic Structures. J Biomed Nanotechnol. 2015;11:325-33 pubmed
    ..The nanoprobe contained an upconversion core, which was green (β-NaYF4:Yb3+/Ho3+) or red (β-NaYF4:Yb3+/Er3+), and a nonporous silica shell to allow for multicolor imaging...
  8. Moen S, Edwards T, Dranow D, Clifton M, Sankaran B, Van Voorhis W, et al. Ligand co-crystallization of aminoacyl-tRNA synthetases from infectious disease organisms. Sci Rep. 2017;7:223 pubmed publisher
    ..bound to glutamic acid, a TrpRS from the eukaryotic pathogen Encephalitozoon cuniculi bound to tryptophan, a HisRS from Burkholderia thailandensis bound to histidine, and a LysRS from Burkholderia thailandensis bound to lysine...
  9. Lageix S, Zhang J, Rothenburg S, Hinnebusch A. Interaction between the tRNA-binding and C-terminal domains of Yeast Gcn2 regulates kinase activity in vivo. PLoS Genet. 2015;11:e1004991 pubmed publisher
    ..genetic approach to identify a key regulatory surface in Gcn2 that is proximal to the predicted active site of the HisRS domain and likely remodeled by tRNA binding...

More Information

Publications55

  1. Dursun F, Mohamoud H, Karim N, Naeem M, Jelani M, Kirmizibekmez H. A Novel Missense Mutation in the CLPP Gene Causing Perrault Syndrome Type 3 in a Turkish Family. J Clin Res Pediatr Endocrinol. 2016;8:472-477 pubmed publisher
    ..Mutations in five genes, i.e. HSD17B4, HARS2, CLPP, LARS2, and C10orf2, have been reported in five subtypes of PRLTS...
  2. Soldà G, Caccia S, Robusto M, Chiereghin C, Castorina P, Ambrosetti U, et al. First independent replication of the involvement of LARS2 in Perrault syndrome by whole-exome sequencing of an Italian family. J Hum Genet. 2016;61:295-300 pubmed publisher
    ..Recently, mutations in five genes (HSD17B4, HARS2, CLPP, LARS2 and C10ORF2) were found to be responsible for Perrault syndrome, although they do not account for all ..
  3. Li J, Hao Z, Zhang X, Luo Y, Zhao J, Lu S, et al. Hydrothermal synthesis and upconversion luminescence properties of ?-NaGdF4:Yb3+/Tm3+ and ?-NaGdF4:Yb3+/Ho3+ submicron crystals with regular morphologies. J Colloid Interface Sci. 2013;392:206-212 pubmed publisher
    ..These UCL were responsible for three, five, and six photons processes determined by pump power dependence of UCL intensities. The observation of UCL of Gd(3+) implied occurrence of energy transfer from Tm(3+):(1)I(6) to Gd(3+):(6)P(J). ..
  4. Zhang H, Liu T, Yin C, Wen Y, Chao J, Zhang Y, et al. A novel ratiometric fluorescent probe based on 1, 8-naphthalimide for the detection of Ho3+ and its bioimaging. Spectrochim Acta A Mol Biomol Spectrosc. 2017;174:230-235 pubmed publisher
    ..This probe was expected to be a useful tool for further elucidating the roles of Ho3+ in materials, biology and environment. ..
  5. Rao B, Jackman J. Life without post-transcriptional addition of G-1: two alternatives for tRNAHis identity in Eukarya. RNA. 2015;21:243-53 pubmed publisher
    ..lacks the G-1 identity element on tRNA(His) and utilizes a noncanonical G-1-independent histidyl-tRNA synthetase (HisRS). Purified HisRS enzymes from A. castellanii and T...
  6. Zhu J, Wang H, Zhang Q, Dong W, Kong D, Wang Y, et al. Arenimonas alkanexedens sp. nov., isolated from a frozen soil sample. Antonie Van Leeuwenhoek. 2017;110:1027-1034 pubmed publisher
    ..0%), Arenimonas aquaticum NA-09T (97.9%), Arenimonas donghaensis HO3-R19T (95.6%) and Arenimonas aestuarii S2-21T (95.3%)...
  7. Zhang Z, Liu Y, Han P, Zhuang S, Wang T, Luo S, et al. Metallofullerenes encaging mixed-metal clusters: synthesis and structural studies of Gdx Ho3-x N@C80 and Gdx Lu3-x N@C80. Chemphyschem. 2015;16:295-8 pubmed publisher
    Metallofullerenes of Gdx Ho3-x N@C80 and Gdx Lu3-x N@C80 encapsulating mixed-metal nitride clusters were synthesized...
  8. Tian Q, Wang C, Liu Y, Xie W. Structural basis for recognition of G-1-containing tRNA by histidyl-tRNA synthetase. Nucleic Acids Res. 2015;43:2980-90 pubmed publisher
    ..a guanine base at position -1 (G-1), and it serves as a major recognition element for histidyl-tRNA synthetase (HisRS)...
  9. Li W, Wu J, Guan X, Zhou Z, Xu H, Luo Z, et al. Efficient continuous-wave and short-pulse Ho3+-doped fluorozirconate glass all-fiber lasers operating in the visible spectral range. Nanoscale. 2018;10:5272-5279 pubmed publisher
    ..To the best of our knowledge, this work is the first demonstration of Ho:ZBLAN all-fiber lasers emitting in the visible spectral range (i.e., both green and deep-red wavelengths). ..
  10. Hu X, Zhu J, Li X, Zhang X, Meng Q, Yuan L, et al. Dextran-coated fluorapatite crystals doped with Yb3+/Ho3+ for labeling and tracking chondrogenic differentiation of bone marrow mesenchymal stem cells in vitro and in vivo. Biomaterials. 2015;52:441-51 pubmed publisher
    ..Here, we synthesized upconversion fluorescent crystals from rare-earth Yb3+ and Ho3+ co-doped fluorapatite (FA:Yb3+/Ho3+) suitable for long-term tracking and monitoring cartilage development (..
  11. Li J, Luo H, Wang L, Zhao C, Zhang H, Li H, et al. 3-μm Mid-infrared pulse generation using topological insulator as the saturable absorber. Opt Lett. 2015;40:3659-62 pubmed publisher
    We report an 1150-nm diode-pump passively Q-switched Ho3+-doped ZBLAN fiber laser using topological insulator (TI): Bi2Te3 as the saturable absorber (SA)...
  12. Yao C, He C, Jia Z, Wang S, Qin G, Ohishi Y, et al. Holmium-doped fluorotellurite microstructured fibers for 2.1 μm lasing. Opt Lett. 2015;40:4695-8 pubmed publisher
    Holmium (Ho3+)-doped fluorotellurite microstructured fibers based on TeO2-BaF2-Y2O3 glasses are fabricated by using a rod-in-tube method. By using a 1.992 μm fiber laser as the pump source, lasing at 2...
  13. Ahmed S, Jelani M, Alrayes N, Mohamoud H, Almramhi M, Anshasi W, et al. Exome analysis identified a novel missense mutation in the CLPP gene in a consanguineous Saudi family expanding the clinical spectrum of Perrault Syndrome type-3. J Neurol Sci. 2015;353:149-54 pubmed publisher
    ..Mutations in five genes, HSD17B4, HARS2, CLPP, LARS2, and C10orf2, have been reported in five subtypes of PRLTS...
  14. Jenkinson E, Rehman A, Walsh T, Clayton Smith J, Lee K, Morell R, et al. Perrault syndrome is caused by recessive mutations in CLPP, encoding a mitochondrial ATP-dependent chambered protease. Am J Hum Genet. 2013;92:605-13 pubmed publisher
    ..Together with the previous identification of mutations in HARS2, encoding mitochondrial histidyl-tRNA synthetase, mutations in CLPP expose dysfunction of mitochondrial protein ..
  15. Escobedo Cruz F, Hughbanks T. New coordination networks containing trinuclear lanthanide complexes and hexacyanometallates. Dalton Trans. 2018;47:6831-6841 pubmed publisher
    ..Using [Co(CN)6]3-, a new family of compounds characterized by 1D-chains is obtained when the trinuclear cluster has Ho3+, Er3+ and Y3+ ions, which crystallize in the Pnma space group...
  16. Nishio S, Takumi Y, Usami S. Laser-capture micro dissection combined with next-generation sequencing analysis of cell type-specific deafness gene expression in the mouse cochlea. Hear Res. 2017;348:87-97 pubmed publisher
    ..As a notable result, the genes associated with many kinds of syndromic hearing loss (such as Clpp, Hars2, Hsd17b4, Lars2 for Perrault syndrome, Polr1c and Polr1d for Treacher Collins syndrome, Ndp for Norrie Disease, ..
  17. Savchuk O, Carvajal J, Brites C, Carlos L, Aguiló M, Diaz F. Upconversion thermometry: a new tool to measure the thermal resistance of nanoparticles. Nanoscale. 2018;10:6602-6610 pubmed publisher
    ..In this work, we demonstrated that KLu(WO4)2:Ho3+,Tm3+ nanoparticles are able to combine controllable heat release and upconversion thermometry permitting to ..
  18. Koh C, Wetzel A, de van der Schueren W, Hol W. Comparison of histidine recognition in human and trypanosomatid histidyl-tRNA synthetases. Biochimie. 2014;106:111-20 pubmed publisher
    ..The H-state Hs-cHisRS undergoes conformational changes in active site residues and several conserved motif of HisRS, compared to F-state structures...
  19. Ołdak M, Oziębło D, Pollak A, Stepniak I, Lazniewski M, Lechowicz U, et al. Novel neuro-audiological findings and further evidence for TWNK involvement in Perrault syndrome. J Transl Med. 2017;15:25 pubmed publisher
    ..Mutations in one of five different genes HSD17B4, HARS2, LARS2, CLPP or TWNK (previous symbol C10orf2) cause the autosomal recessive disorder but they are found only in ..
  20. Baklanova Y, Lipina O, Maksimova L, Tyutyunnik A, Leonidov I, Denisova T, et al. Nd3+, Ho3+-codoped garnet-related Li7La3Hf2O12 phosphor with NIR luminescence. Spectrochim Acta A Mol Biomol Spectrosc. 2017;180:105-109 pubmed publisher
    ..Possible energy transfer mechanisms between lanthanide ions have been briefly discussed. ..
  21. Lee Y, Chang C, Cheng Y, Kuo Y, Lin Y, Wang C. Evolutionary gain of highly divergent tRNA specificities by two isoforms of human histidyl-tRNA synthetase. Cell Mol Life Sci. 2017;74:2663-2677 pubmed publisher
    ..We present evidence herein that yeast histidyl-tRNA synthetase (HisRS) recognizes both A73 and C73, but somewhat prefers A73 even within the context of mitochondrial tRNAHis...
  22. Cao W, Wang T, Huang F, Wang Z, Hua Y, Lei R, et al. Tuning the micro-structure of germanosilicate glass to control Bi0/Bi+ and promote efficient Ho3+ fluorescence. Dalton Trans. 2018;47:9717-9723 pubmed publisher
    ..In this work, efficient enhancement of Ho3+ emission is observed with the change in local glass environment around Bi by adding Al2O3 to multi-component ..
  23. Englert M, Vargas Rodriguez O, Reynolds N, Wang Y, Soll D, Umehara T. A genomically modified Escherichia coli strain carrying an orthogonal E. coli histidyl-tRNA synthetase•tRNAHis pair. Biochim Biophys Acta Gen Subj. 2017;1861:3009-3015 pubmed publisher
    ..The Escherichia coli and Caulobacter crescentus histidyl-tRNA synthetases (HisRS) evolved divergent mechanisms of tRNAHis recognition that prevent their cross-reactivity...
  24. Angeli G, Sartsidou C, Vlahaki S, Spanopoulos I, Tsangarakis C, Kourtellaris A, et al. Reticular Chemistry and the Discovery of a New Family of Rare Earth (4, 8)-Connected Metal-Organic Frameworks with csq Topology Based on RE4(?3-?)2(COO)8 Clusters. ACS Appl Mater Interfaces. 2017;: pubmed publisher
    ..report here a new family of RE-MOFs featuring the novel inorganic building unit, RE4(?3-?)2 (RE: Y3+, Tb3+, Dy3+, Ho3+, Er3+ and Yb3+), with planar D2h symmetry...
  25. Lu D, Guan D. Photoluminescence associated with the site occupations of Ho3+ ions in BaTiO3. Sci Rep. 2017;7:6125 pubmed publisher
    ..The PL effect may provide a probe for the site occupations of Ho3+ ions in widely-used BaTiO3 dielectric ceramics co-doped with Ho3+ and other dopants. ..
  26. Pierce S, Chisholm K, Lynch E, Lee M, Walsh T, Opitz J, et al. Mutations in mitochondrial histidyl tRNA synthetase HARS2 cause ovarian dysgenesis and sensorineural hearing loss of Perrault syndrome. Proc Natl Acad Sci U S A. 2011;108:6543-8 pubmed publisher
    ..of Perrault syndrome to be compound heterozygosity for mutations in the mitochondrial histidyl tRNA synthetase HARS2 at two highly conserved amino acids, L200V and V368L. The nucleotide substitution creating HARS2 p...
  27. O Hanlon T, Raben N, Miller F. A novel gene oriented in a head-to-head configuration with the human histidyl-tRNA synthetase (HRS) gene encodes an mRNA that predicts a polypeptide homologous to HRS. Biochem Biophys Res Commun. 1995;210:556-66 pubmed
    ..DNA clone that encodes portions of these oppositely transcribed mRNAs and a putatively full-length cDNA clone (HO3) corresponding to the gene mapping immediately 5' of HRS...
  28. Tsui H, Mok S, de Souza L, Martin A, Tsui F. Transcriptional analyses of the gene region that encodes human histidyl-tRNA synthetase: identification of a novel bidirectional regulatory element. Gene. 1993;131:201-8 pubmed
    ..From mobility shift assays using HeLa cell nuclear extracts and this 27-bp oligo, we have identified two DNA-protein complexes, both of which are presumably required to initiate bidirectional transcription. ..
  29. Xu X, Zhou S, Long J, Wu T, Fan Z. The Synthesis of a Core-Shell Photocatalyst Material YF?:Ho3+@TiO? and Investigation of Its Photocatalytic Properties. Materials (Basel). 2017;10: pubmed publisher
  30. Raben N, Borriello F, Amin J, Horwitz R, Fraser D, Plotz P. Human histidyl-tRNA synthetase: recognition of amino acid signature regions in class 2a aminoacyl-tRNA synthetases. Nucleic Acids Res. 1992;20:1075-81 pubmed
  31. Xing L, Yang W, Lin J, Huang M, Xue Y. Enhanced and Stable Upconverted White-light Emission in Ho3+/Yb3+/Tm3+-doped LiNbO3 Single Crystal via Mg2+ Ion Doping. Sci Rep. 2017;7:14725 pubmed publisher
    ..Therefore, Mg2+ ion doped Ho3+/Yb3+/Tm3+/LiNbO3 single crystals would have potential applications in stable white-light devices and photoelectric instruments. ..
  32. Hong Y, Yi T, Tan X, Su J, Ge F. Microbes affected the TYLCCNV transmission rate by the Q biotype whitefly under high O3. Sci Rep. 2017;7:14412 pubmed publisher
    ..In this study we studied how hO3 affected the transmission of the Tomato yellow leaf curl China virus (TYLCCNV), a begomovirus, by the Q biotype ..
  33. Fan Z, Wu T, Xu X. Synthesis of Reduced Grapheme Oxide as A Platform for loading ?-NaYF4:Ho3+@TiO2Based on An Advanced Visible Light-Driven Photocatalyst. Sci Rep. 2017;7:13833 pubmed publisher
    ..It is of great significance to design an effective solar light-driven photocatalysis in promoting environmental protection. ..
  34. Xiang G, Ma Y, Liu W, Wang J, Gu Z, Jin Y, et al. Enhancement of Eu3+ Red Upconversion in Lu2O3: Yb3+/Eu3+ Powders under the Assistance of Bridging Function Originated from Ho3+ Tridoping. Inorg Chem. 2017;56:13955-13961 pubmed publisher
    ..5 mol % Ho3+ is increased by a factor of 8...
  35. Abbott J, Guth E, Kim C, Regan C, Siu V, Rupar C, et al. The Usher Syndrome Type IIIB Histidyl-tRNA Synthetase Mutation Confers Temperature Sensitivity. Biochemistry. 2017;56:3619-3631 pubmed publisher
    ..revealed that the kinetics of amino acid activation differs from that of the previously characterized bacterial HisRS. Despite the similar kinetics, differential scanning fluorimetry revealed that Y454S is less thermally stable than ..
  36. Peng L, Huang Y, Duan Y, Zhuang S, Liao T, Xu C. 2???m laser oscillation of Ho3+:Tm3+-codoped silica microspheres. Appl Opt. 2017;56:7469-7473 pubmed publisher
    ..The free spectral range is in good accordance with the calculated value based on Mie scattering theory. The HTCSM laser oscillation shows characteristics of good capability, simple process, high flexibility, and low cost...
  37. Kosaki R, Horikawa R, Fujii E, Kosaki K. Biallelic mutations in LARS2 can cause Perrault syndrome type 2 with neurologic symptoms. Am J Med Genet A. 2018;176:404-408 pubmed publisher
    ..Causative genes include HARS2, HSD17B4, CLPP, C10orf2, and LARS2...
  38. Syamchand S, Aparna R, George S. Surface Engineered Ho3+ Incorporated Fluorescent Dye-Doped Bifunctional Silica Nanoparticles for Receptor Targeted Fluorescence Imaging and Potential Magnetic Resonance Imaging. J Fluoresc. 2017;27:1897-1908 pubmed publisher
    ..The luminescence and magnetism together with biocompatibility enables the adaptability of the present system as a nano platform for potential bimodal imaging. Graphical Abstract ?. ..
  39. Pilch A, Würth C, Kaiser M, Wawrzynczyk D, Kurnatowska M, Arabasz S, et al. Shaping Luminescent Properties of Yb3+ and Ho3+ Co-Doped Upconverting Core-Shell ?-NaYF4 Nanoparticles by Dopant Distribution and Spacing. Small. 2017;: pubmed publisher
  40. Freist W, Verhey J, Rühlmann A, Gauss D, Arnez J. Histidyl-tRNA synthetase. Biol Chem. 1999;380:623-46 pubmed
    Histidyl-tRNA synthetase (HisRS) is responsible for the synthesis of histidyl-transfer RNA, which is essential for the incorporation of histidine into proteins...
  41. Zhang J, Lu Y, Cai M, Tian Y, Huang F, Guo Y, et al. 2.8??m emission and OH quenching analysis in Ho3+ doped fluorotellurite-germanate glasses sensitized by Yb3+ and Er3. Sci Rep. 2017;7:16794 pubmed publisher
    ..Results reveal that Er3+/Ho3+/Yb3+ triply-doped fluorotellurite-germanate glass is a potential kind of laser glass for efficient 3??m laser. ..
  42. Sirusi A, Suh E, Kovacs Z, Merritt M. The effect of Ho3+ doping on 13C dynamic nuclear polarization at 5 T. Phys Chem Chem Phys. 2018;20:728-731 pubmed publisher
    ..The optimum Ho-DOTA concentration was 2 mM. In addition, the microwave sweep spectrum changes character in a manner that suggests both the cross effect and thermal mixing are active mechanisms for trityl radical at 5 T and 1.2 K. ..
  43. Fulle K, Sanjeewa L, McMillen C, Kolis J. Crystal chemistry and the role of ionic radius in rare earth tetrasilicates: Ba2RE2Si4O12F2 (RE = Er3+-Lu3+) and Ba2RE2Si4O13 (RE = La3+-Ho3+). Acta Crystallogr B Struct Sci Cryst Eng Mater. 2017;73:907-915 pubmed publisher
    ..The single crystals are grown from high-temperature (ca 953?K) hydrothermal fluids, demonstrating the versatility of the technique to access new phases containing recalcitrant rare earth oxides, enabling the study of structural trends...
  44. Lama J, Trono D. Human immunodeficiency virus type 1 matrix protein interacts with cellular protein HO3. J Virol. 1998;72:1671-6 pubmed
    ..A specific interaction between MA and HO3, a putative histidyl-tRNA synthetase, was demonstrated in this system...
  45. Wei C, Shi H, Luo H, Zhang H, Lyu Y, Liu Y. 34 nm-wavelength-tunable picosecond Ho3+/Pr3+-codoped ZBLAN fiber laser. Opt Express. 2017;25:19170-19178 pubmed publisher
    ..Such simple, robust, and versatile mid-infrared picosecond laser source can find various applications in laser surgery, spectroscopy, and nonlinear frequency conversion...