GSTM1

Summary

Gene Symbol: GSTM1
Description: glutathione S-transferase mu 1
Alias: GST1, GSTM1-1, GSTM1a-1a, GSTM1b-1b, GTH4, GTM1, MU-1, glutathione S-transferase Mu 1, GST HB subunit 4, GST class-mu 1, HB subunit 4, S-(hydroxyalkyl)glutathione lyase, glutathione S-alkyltransferase, glutathione S-aralkyltransferase, glutathione S-aryltransferase, glutathione S-transferase M1
Species: human
Products:     GSTM1

Top Publications

  1. Lam T, Gallicchio L, Lindsley K, Shiels M, Hammond E, Tao X, et al. Cruciferous vegetable consumption and lung cancer risk: a systematic review. Cancer Epidemiol Biomarkers Prev. 2009;18:184-95 pubmed publisher
    ..intake and lung cancer risk, with an emphasis on the potential interaction between cruciferous vegetables and GSTM1 and GSTT1 gene variants...
  2. Shaheen S, Newson R, Ring S, Rose Zerilli M, Holloway J, Henderson A. Prenatal and infant acetaminophen exposure, antioxidant gene polymorphisms, and childhood asthma. J Allergy Clin Immunol. 2010;126:1141-8.e7 pubmed publisher
    ..006), and risk of wheezing was increased when maternal GSTM1 was present (P interaction, .04)...
  3. Rothman N, Garcia Closas M, Chatterjee N, Malats N, Wu X, Figueroa J, et al. A multi-stage genome-wide association study of bladder cancer identifies multiple susceptibility loci. Nat Genet. 2010;42:978-84 pubmed publisher
    ..3, 8q24.21 and 8q24.3, validated previous candidate associations for the GSTM1 deletion (P = 4 × 10⁻¹¹) and a tag SNP for NAT2 acetylation status (P = 4 × 10⁻¹¹), ..
  4. Oz O, Aras Ates N, Tamer L, Yildirim O, Adiguzel U. Glutathione S-transferase M1, T1, and P1 gene polymorphism in exudative age-related macular degeneration: a preliminary report. Eur J Ophthalmol. 2006;16:105-10 pubmed
    ..To elucidate whether the gene polymorphisms of glutathione S-transferase (GST) M1, T1, and P1 are associated with the development of exudative age-related macular degeneration...
  5. Li C, Yin Z, Zhou B. [CYP1A1 gene and GSTM1 gene polymorphism and the combined effects and risk of lung cancer: a meta-analysis]. Zhongguo Fei Ai Za Zhi. 2011;14:660-8 pubmed publisher
    Cytochrome P450A1 (CYP1A1) gene and glutathione S-transferase M1 (GSTM1) gene both have single nucleotide polymorphisms and effects on lung cancer...
  6. Reddy P, Naidoo R, Robins T, Mentz G, London S, Li H, et al. GSTM1, GSTP1, and NQO1 polymorphisms and susceptibility to atopy and airway hyperresponsiveness among South African schoolchildren. Lung. 2010;188:409-14 pubmed publisher
    Glutathione-S-transferases (GSTM1 and GSTP1) and nicotinamide quinone oxidoreductase (NQO1) genes play an important role in cellular protection against oxidative stress which has been linked to asthma pathogenesis...
  7. Lam T, Ruczinski I, Helzlsouer K, Shugart Y, Li K, Clipp S, et al. Copy number variants of GSTM1 and GSTT1 in relation to lung cancer risk in a prospective cohort study. Ann Epidemiol. 2009;19:546-52 pubmed publisher
    Previous studies did not discriminate wild-type from hemizygous genotypes of GSTM1 and GSTT1. In this study, we investigated wild-type, hemizygous deletion, and homozygous deletion genotypes of GSTM1 and GSTT1 and lung cancer risk...
  8. Dillon M, Harris B, Hernandez M, Zou B, Reed W, Bromberg P, et al. Enhancement of systemic and sputum granulocyte response to inhaled endotoxin in people with the GSTM1 null genotype. Occup Environ Med. 2011;68:783-5 pubmed publisher
    To determine if the GSTM1 null genotype is a risk factor for increased inflammatory response to inhaled endotoxin...
  9. Zheng D, Hua F, Mei C, Wan H, Zhou Q. [Association between GSTM1 genetic polymorphism and lung cancer risk by SYBR green I real-time PCR assay]. Zhongguo Fei Ai Za Zhi. 2010;13:506-10 pubmed publisher
    Glutathione S-transferase M1 (GSTM1) is an important phase II metabolic enzyme gene which involves metabolism of various carcinogens in human body. Many studies showed that GSTM1 genetic polymorphism was associated with lung cancer risk...

More Information

Publications90

  1. Tripathi S, Ghoshal U, Mittal B, Chourasia D, Kumar S, Ghoshal U. Association between gastric mucosal glutathione-S-transferase activity, glutathione-S-transferase gene polymorphisms and Helicobacter pylori infection in gastric cancer. Indian J Gastroenterol. 2011;30:257-63 pubmed publisher
    ..03), but GSH levels were comparable. GSTT1 null genotype (GSTT1*0) and simultaneous deletion of both GSTT1 and GSTM1 genes was associated with lower enzyme activity (p?=?0.02 and 0.01, respectively). GST and GSH levels in H...
  2. Xue H, Su J, Sun K, Xie W, Wang H. Glutathione S-transferase M1 and T1 gene polymorphism and COPD risk in smokers: an updated analysis. Mol Biol Rep. 2012;39:5033-42 pubmed publisher
    We evaluated the association between GSTM1 and GSTT1 gene polymorphisms and susceptibility to chronic obstructive pulmonary disease (COPD) in smokers. A meta-analysis of the published case-control studies was performed...
  3. Savic Radojevic A, Djukic T, Simic T, Pljesa Ercegovac M, Dragicevic D, Pekmezovic T, et al. GSTM1-null and GSTA1-low activity genotypes are associated with enhanced oxidative damage in bladder cancer. Redox Rep. 2013;18:1-7 pubmed
    ..the association between gene variants of the detoxifying and antioxidant enzymes glutathione transferase M1 (GSTM1) and glutathione transferase A1 (GSTA1) and the extent of oxidative damage in patients with transitional cell ..
  4. Wei B, Xu Z, Zhou Y, Ruan J, Cheng H, Xi B, et al. Association of GSTM1 null allele with prostate cancer risk: evidence from 36 case-control studies. PLoS ONE. 2012;7:e46982 pubmed publisher
    Glutathione S-transferase M1 (GSTM1) is thought to be involved in detoxifying several carcinogens and may play a vital role in tumorigenesis...
  5. Chen C, Jin Y, Xu H, Zhang C, Zhang H, Zhang W, et al. [Effects of CYP1A1 and GSTM1 gene polymorphisms and BPDE-DNA adducts on lung cancer]. Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2012;29:23-7 pubmed publisher
    To investigate the effect of CYP1A1 and GSTM1 genetic polymorphisms and BPDE-DNA adducts on lung tumorigenesis. The case control study has included 200 cases of lung cancer and 200 controls...
  6. Cilensek I, Mankoc S, Petrovic M, Petrovic D. GSTT1 null genotype is a risk factor for diabetic retinopathy in Caucasians with type 2 diabetes, whereas GSTM1 null genotype might confer protection against retinopathy. Dis Markers. 2012;32:93-9 pubmed publisher
    ..was to investigate whether the genetic polymorphisms: polymorphic deletions of glutathione S-transferases M1 (GSTM1) and T1 (GSTT1) and Ile105Val of the GSTP1 are associated with DR in Slovenian patients with type 2 diabetes...
  7. Shukla R, Tilak A, Kumar C, Kant S, Kumar A, Mittal B, et al. Associations of CYP1A1, GSTM1 and GSTT1 polymorphisms with lung cancer susceptibility in a Northern Indian population. Asian Pac J Cancer Prev. 2013;14:3345-9 pubmed
    ..by inheritance of polymorphic genes encoding cytochrome P450 1A1 (CYP1A1) and glutathione S transferases (GSTM1 and GSTT1), which are involved in the bioactivation and detoxification of environmental toxins...
  8. Liu Y, Xu L. Meta-analysis of association between GSTM1 gene polymorphism and cervical cancer. Asian Pac J Trop Med. 2012;5:480-4 pubmed publisher
    ..All studies evaluating the association between GSTM1/GSTT1 polymorphisms and cervical were included...
  9. Liang S, Wei X, Gong C, Wei J, Chen Z, Chen X, et al. Significant association between asthma risk and the GSTM1 and GSTT1 deletion polymorphisms: an updated meta-analysis of case-control studies. Respirology. 2013;18:774-83 pubmed publisher
    Polymorphisms in GSTM1 and GSTT1 may be associated with asthma risk, yet several studies and meta-analyses have reported inconclusive results. Therefore, an updated meta-analysis was conducted...
  10. Li C, Long J, Hu X, Zhou Y. GSTM1 and GSTT1 genetic polymorphisms and risk of anti-tuberculosis drug-induced hepatotoxicity: an updated meta-analysis. Eur J Clin Microbiol Infect Dis. 2013;32:859-68 pubmed publisher
    The results of studies investigating the associations between GSTM1 and GSTT1 polymorphisms and anti-tuberculosis drug-induced hepatotoxicity (ADIH) risk exhibit much controversy...
  11. Huang W, Wang W, Zhou M, Chen S, Zhang X. Association of glutathione S-transferase polymorphisms (GSTM1 and GSTT1) with primary open-angle glaucoma: an evidence-based meta-analysis. Gene. 2013;526:80-6 pubmed publisher
    ..Therefore, a meta-analysis was performed to clarify the effects of GSTM1 and GSTT1 polymorphisms on POAG risk...
  12. Sharma A, Pandey A, Sardana S, Sehgal A, Sharma J. Genetic polymorphisms of GSTM1 and GSTT1 genes in Delhi and comparison with other Indian and global populations. Asian Pac J Cancer Prev. 2012;13:5647-52 pubmed
    ..In the present study, GSTM1 and GSTT1 polymorphisms were analysed using a multiplex polymerase chain reaction in 500 normal individuals from ..
  13. Lima C, Ortega M, Marson F, Zulli R, Ribeiro A, Bertuzzo C. Cystic fibrosis transmembrane conductance regulator gene mutations and glutathione S-transferase null genotypes in cystic fibrosis patients in Brazil. J Bras Pneumol. 2012;38:50-6 pubmed
    ..transmembrane conductance regulator (CFTR) gene and deletion of the glutathione S-transferase (GST) genes mu-1 (GSTM1) and theta-1 (GSTT1) have on the clinical course of cystic fibrosis (CF) in patients residing in the southeastern ..
  14. Zhang J, Liu H, Yan H, Huang G, Wang B. Null genotypes of GSTM1 and GSTT1 contribute to increased risk of diabetes mellitus: a meta-analysis. Gene. 2013;518:405-11 pubmed publisher
    ..Glutathione S-Transferase M1 (GSTM1) and Glutathione S-Transferase T1 (GSTT1) genes are polymorphic in human and the null genotypes lead to the ..
  15. Cora T, Tokac M, Acar H, Soylu A, Inan Z. Glutathione S-transferase M1 and T1 genotypes and myocardial infarction. Mol Biol Rep. 2013;40:3263-7 pubmed publisher
    ..We investigated the association between the GSTM1 and GSTT1 gene polymorphisms and MI...
  16. Zhang A, Liu B, Wang L, Gao Y, Li F, Sun S. Glutathione S-transferase gene polymorphisms and risk of gastric cancer in a Chinese population. Asian Pac J Cancer Prev. 2011;12:3421-5 pubmed
    The potential role of GSTM1, GSTT1 and GSTP1 polymorphisms in risk of gastric cancer in Chinese was studied...
  17. López Cima M, Álvarez Avellón S, Pascual T, Fernandez Somoano A, Tardon A. Genetic polymorphisms in CYP1A1, GSTM1, GSTP1 and GSTT1 metabolic genes and risk of lung cancer in Asturias. BMC Cancer. 2012;12:433 pubmed publisher
    ..We investigated if the individual and/or combined modifying effects of the CYP1A1 MspI T6235C, GSTM1 present/null, GSTT1 present/null and GSTP1 Ile105Val polymorphisms are related to the risk of developing lung ..
  18. Wu W, Peden D, Diaz Sanchez D. Role of GSTM1 in resistance to lung inflammation. Free Radic Biol Med. 2012;53:721-9 pubmed publisher
    ..Among these antioxidant genes, glutathione S-transferase Mu 1 (GSTM1) has been most extensively characterized because it has a null polymorphism that is highly prevalent in the ..
  19. Malakar M, Devi K, Phukan R, Kaur T, Deka M, Puia L, et al. Genetic polymorphism of glutathione S-transferases M1 and T1, tobacco habits and risk of stomach cancer in Mizoram, India. Asian Pac J Cancer Prev. 2012;13:4725-32 pubmed
    ..b>GSTM1 and GSTT1 genotypes were determined by PCR and H. pylori infections were determined by ELISA...
  20. Singla N, Gupta D, Birbian N, Singh J. Association of NAT2, GST and CYP2E1 polymorphisms and anti-tuberculosis drug-induced hepatotoxicity. Tuberculosis (Edinb). 2014;94:293-8 pubmed publisher
    ..The genetic polymorphisms of the NAT2 and CYP2E1 genes were studied by PCR-RFLP and GSTM1 and GSTT1 were evaluated by multiplex PCR...
  21. Liu D, Wang F, Wang Q, Guo X, Xu H, Wang W, et al. Association of glutathione S-transferase M1 polymorphisms and lung cancer risk in a Chinese population. Clin Chim Acta. 2012;414:188-90 pubmed publisher
    Genetic polymorphisms of glutathione S-transferase M1 (GSTM1) are thought to have significant effects on the metabolism of environmental carcinogens and thus on lung cancer risk, but the reported results are not always consistent...
  22. García González M, Quintero E, Bujanda L, Nicolas D, Benito R, Strunk M, et al. Relevance of GSTM1, GSTT1, and GSTP1 gene polymorphisms to gastric cancer susceptibility and phenotype. Mutagenesis. 2012;27:771-7 pubmed publisher
    ..DNA from 557 GC patients and 557 sex- and age-matched healthy controls (HC) was typed for two deletions in the GSTM1 and GSTT1 genes and two SNPs in the GSTP1 gene (rs1695 and rs1138272) using polymerase chain reaction-restriction ..
  23. Reddy P, Naidoo R, Robins T, Mentz G, Li H, London S, et al. GSTM1 and GSTP1 gene variants and the effect of air pollutants on lung function measures in South African children. Am J Ind Med. 2012;55:1078-86 pubmed publisher
    ..These genes include GSTM1 (glutathione-S-transferase M1 gene) and GSTP1 (glutathione-S-transferase P1 gene), which may modulate the response ..
  24. Rudolph A, Hein R, Hoffmeister M, Forsti A, Hemminki K, Risch A, et al. Copy number variations of GSTT1 and GSTM1, colorectal cancer risk and possible effect modification of cigarette smoking and menopausal hormone therapy. Int J Cancer. 2012;131:E841-8 pubmed publisher
    Copy number variations (CNVs) of the glutathione-S-transferase ?-1 (GSTT1) and glutathione-S-transferase ?-1 (GSTM1) gene loci can lead to complete lack of enzyme and have been associated with colorectal cancer (CRC) risk...
  25. Wang N, Wu Y, Zhou X, Wu Y. [Association between genetic polymorphism of metabolizing enzymes and DNA repairing enzymes and the susceptibility of lung cancer in Henan population]. Wei Sheng Yan Jiu. 2012;41:251-6 pubmed
    ..healthy control subjects was conducted in Henan population to investigate the role of CYP1A1-Msp1, CYP1A1-exon7, GSTM1, GSTT1, mEH-exon3, mEH-exon4 and XRCC1 in lung cancer...
  26. Cheng H, You H, Zhou T. Relationship between GSTM1/GSTT1 null genotypes and renal cell carcinoma risk: a meta-analysis. Ren Fail. 2012;34:1052-7 pubmed publisher
    The results from the published studies on the relationship between GSTM1/GSTT1 null genotypes and renal cell carcinoma (RCC) risk are still conflicting...
  27. Li F, Li S, Chang H, Nie Y, Zeng L, Zhang X, et al. Quantitative assessment of the association between the GSTM1-null genotype and the risk of childhood asthma. Genet Test Mol Biomarkers. 2013;17:656-61 pubmed publisher
    Many studies investigated the association between the glutathione S-transferase M 1 (GSTM1)-null genotype and childhood asthma risk, but there was obvious inconsistence among those studies...
  28. Matic M, Pekmezovic T, Djukic T, Mimic Oka J, Dragicevic D, Krivic B, et al. GSTA1, GSTM1, GSTP1, and GSTT1 polymorphisms and susceptibility to smoking-related bladder cancer: a case-control study. Urol Oncol. 2013;31:1184-92 pubmed publisher
    Glutathione S-transferases (GSTs) are a family of enzymes involved in detoxification. Genes encoding for GSTA1, GSTM1, GSTP1, and GSTT1 proteins are polymorphic, which can result in complete or partial loss of enzyme activity...
  29. Yeh H, Kuo L, Sung F, Chiang C, Yeh C. GSTM1, GSTT1, GSTP1, and GSTA1 genetic variants are not associated with coronary artery disease in Taiwan. Gene. 2013;523:64-9 pubmed publisher
    ..To investigate the genetic factors for CAD, we examined the GSTM1, GSTT1, GSTP1, and GSTA1 genotypes in a CAD cohort in Taiwan...
  30. Liu K, Zhang L, Lin X, Chen L, Shi H, Magaye R, et al. Association of GST genetic polymorphisms with the susceptibility to hepatocellular carcinoma (HCC) in Chinese population evaluated by an updated systematic meta-analysis. PLoS ONE. 2013;8:e57043 pubmed publisher
    Due to the possible involvement of Glutathione S-transferase Mu-1 (GSTM1) and Glutathione S-transferase theta-1 (GSTT1) in the detoxification of environmental carcinogens, environmental toxins, and oxidative stress products, genetic ..
  31. Hoskins A, Reiss S, Wu P, Chen N, Han W, Do R, et al. Asthmatic airway neutrophilia after allergen challenge is associated with the glutathione S-transferase M1 genotype. Am J Respir Crit Care Med. 2013;187:34-41 pubmed publisher
    ..Glutathione S-transferase M1 (GSTM1) is a multifunctional phase II enzyme and regulator of stress-activated cellular signaling relevant to asthma ..
  32. Monteiro T, El Jaick K, Jeovanio Silva A, Brasil P, Costa M, Rolla V, et al. The roles of GSTM1 and GSTT1 null genotypes and other predictors in anti-tuberculosis drug-induced liver injury. J Clin Pharm Ther. 2012;37:712-8 pubmed publisher
    ..Several studies have investigated the genetic null variants of GSTM1 and GSTT1 as possible risk factors for ATD-induced liver injury; however, those findings are inconsistent...
  33. Wu W, Peden D, McConnell R, Fruin S, Diaz Sanchez D. Glutathione-S-transferase M1 regulation of diesel exhaust particle-induced pro-inflammatory mediator expression in normal human bronchial epithelial cells. Part Fibre Toxicol. 2012;9:31 pubmed publisher
    ..We have demonstrated that the glutathione S-transferase M1 (GSTM1) null genotype could aggravate DEP-induced airway inflammation in human subjects...
  34. Gönül N, Kadioglu E, Kocabas N, Ozkaya M, Karakaya A, Karahalil B. The role of GSTM1, GSTT1, GSTP1, and OGG1 polymorphisms in type 2 diabetes mellitus risk: a case-control study in a Turkish population. Gene. 2012;505:121-7 pubmed publisher
    The aim of the present study was to investigate the role of some polymorphisms in GSTs (GSTM1, GSTT1 and GSTP1) which are very important protective mechanisms against oxidative stress and in OGG1 gene which is important in DNA repair, ..
  35. Vichi S, Medda E, Ingelido A, Ferro A, Resta S, Porpora M, et al. Glutathione transferase polymorphisms and risk of endometriosis associated with polychlorinated biphenyls exposure in Italian women: a gene-environment interaction. Fertil Steril. 2012;97:1143-51.e1-3 pubmed publisher
    ..the occurrence of a gene-environment interaction between glutathione transferase (GST) gene polymorphisms (GSTM1, GSTT1, GSTP1, and GSTA1) and serum polychlorinated biphenyls (PCBs) levels...
  36. Vojtková J, Durdik P, Ciljakova M, Michnová Z, Turcan T, Babusikova E. The association between gene polymorphisms of glutathione S-transferase T1/M1 and type 1 diabetes in Slovak children and adolescents. Cent Eur J Public Health. 2013;21:88-91 pubmed
    ..The aim of the study was to investigate an association of glutathione S-transferase mu 1 (GST M1) and glutathione S-transferase theta 1 (GST T1) polymorphisms with type 1 diabetes...
  37. Tang S, Lv X, Zhang Y, Wu S, Yang Z, Xia Y, et al. CYP2E1, GSTM1 and GSTT1 genetic polymorphisms and susceptibility to antituberculosis drug-induced hepatotoxicity: a nested case-control study. J Clin Pharm Ther. 2012;37:588-93 pubmed publisher
    ..We aimed to investigate possible associations of CYP2E1, GSTM1 and GSTT1 genetic polymorphisms with ATDH using a more robust case-control study nested in a population-based ..
  38. Jing C, Huang Z, Duan Y, Wang P, Zhang R, Luo K, et al. Glulathione-S-transferases gene polymorphism in prediction of gastric cancer risk by smoking and Helicobacter pylori infection status. Asian Pac J Cancer Prev. 2012;13:3325-8 pubmed
    ..Polymorphisms of GSTM1, GSTT1 and GSTP1 were determined using PCR-CTPP...
  39. Hezova R, Bienertova Vasku J, Sachlova M, Brezkova V, Vasku A, Svoboda M, et al. Common polymorphisms in GSTM1, GSTT1, GSTP1, GSTA1 and susceptibility to colorectal cancer in the Central European population. Eur J Med Res. 2012;17:17 pubmed publisher
    ..we investigated associations of polymorphisms in glutathione S-transferases (GSTs) genes, that is GSTA1, GSTT1, GSTM1 and GSTP1, with CRC in a total of 197 cases and 218 controls originating from the Czech Central European ..
  40. Piacentini S, Polimanti R, Moscatelli B, Re M, Manfellotto D, Fuciarelli M. Lack of association between GSTM1, GSTP1, and GSTT1 gene polymorphisms and asthma in adult patients from Rome, central Italy. J Investig Allergol Clin Immunol. 2012;22:252-6 pubmed
    ..few and contradictory data are available on the association between asthma development and GST gene polymorphisms (GSTM1, GSTP1, and GST1)...
  41. Kariz S, Nikolajević Starčević J, Petrovic D. Association of manganese superoxide dismutase and glutathione S-transferases genotypes with myocardial infarction in patients with type 2 diabetes mellitus. Diabetes Res Clin Pract. 2012;98:144-50 pubmed publisher
    ..Val16Ala of manganese superoxide dismutase (MnSOD), polymorphic deletions of glutathione S-transferases M1 (GSTM1) and T1 (GSTT1) and Ile105Val of glutathione S-transferase P1 (GSTP1) and myocardial infarction (MI) in a group of ..
  42. Raimondi S, Boffetta P, Anttila S, Brockmoller J, Butkiewicz D, Cascorbi I, et al. Metabolic gene polymorphisms and lung cancer risk in non-smokers. An update of the GSEC study. Mutat Res. 2005;592:45-57 pubmed
    ..We evaluated the role of the metabolic gene polymorphisms CYP1A1MspI, CYP1A1Ile462Val, GSTM1, and GSTT1 in non-smoker lung cancer patients from the International Collaborative Study on Genetic Susceptibility ..
  43. Yang M, Choi Y, Hwangbo B, Lee J. Combined effects of genetic polymorphisms in six selected genes on lung cancer susceptibility. Lung Cancer. 2007;57:135-42 pubmed
    ..NQO1), cytochrome P450 (CYP)1A1, myeloperoxidase (MPO), glutathione-S-transferase (GST)P1, GSTT1, and GSTM1, and have been suspected to affect lung cancer risk...
  44. Kao C, Chen M, Kuo W, Chen T, Su S, Hsieh Y, et al. Influence of glutathione-S-transferase theta (GSTT1) and micro (GSTM1) gene polymorphisms on the susceptibility of hepatocellular carcinoma in Taiwan. J Surg Oncol. 2010;102:301-7 pubmed publisher
    ..Glutathione-S-transferases theta (GSTT1) and micro (GSTM1) play essential roles in detoxification of ingested xenobiotics and modulation of the susceptibility of gene-..
  45. Teixeira J, Gaspar J, Martinho G, Silva S, Rodrigues S, Mayan O, et al. Aromatic DNA adduct levels in coke oven workers: correlation with polymorphisms in genes GSTP1, GSTM1, GSTT1 and CYP1A1. Mutat Res. 2002;517:147-55 pubmed
    ..hydrocarbons (PAHs) from a coke oven plant and explore the possible association between CYP1A1 MspI, GSTP1, GSTM1 and GSTT1 genotypes, and smoking status on bulky DNA adduct formation...
  46. Hung R, Boffetta P, Brockmoller J, Butkiewicz D, Cascorbi I, Clapper M, et al. CYP1A1 and GSTM1 genetic polymorphisms and lung cancer risk in Caucasian non-smokers: a pooled analysis. Carcinogenesis. 2003;24:875-82 pubmed
    ..for genes encoding the metabolic enzymes cytochrome P450 1A1 (CYP1A1) and glutathione S-transferase M1 (GSTM1) might contribute to the variability in individual susceptibility to lung cancer...
  47. Singh H, Sachan R, Devi S, Pandey S, Mittal B. Association of GSTM1, GSTT1, and GSTM3 gene polymorphisms and susceptibility to cervical cancer in a North Indian population. Am J Obstet Gynecol. 2008;198:303.e1-6 pubmed publisher
    The objective of the study was to evaluate the influence of genetic polymorphisms of GSTM1, GSTT1, and GSTM3 on the susceptibility of cervical cancer...
  48. Clavel J, Bellec S, Rebouissou S, Menegaux F, Feunteun J, Bonaïti Pellié C, et al. Childhood leukaemia, polymorphisms of metabolism enzyme genes, and interactions with maternal tobacco, coffee and alcohol consumption during pregnancy. Eur J Cancer Prev. 2005;14:531-40 pubmed
    ..The polymorphisms of CYP1A1, GSTM1, GSTP1, GSTT1 and NQO1 were not associated with the risk of leukaemia...
  49. Tursen U, Tamer L, Eskandari G, Kaya T, Ates N, Ikizoglu G, et al. Glutathione S-transferase polymorphisms in patients with Behçet's disease. Arch Dermatol Res. 2004;296:185-7 pubmed
  50. Murta Nascimento C, Silverman D, Kogevinas M, Garcia Closas M, Rothman N, Tardon A, et al. Risk of bladder cancer associated with family history of cancer: do low-penetrance polymorphisms account for the increase in risk?. Cancer Epidemiol Biomarkers Prev. 2007;16:1595-600 pubmed
    ..17 (95% CI, 0.17-7.86) among NAT2-rapid/intermediate acetylators (P(interaction) = 0.609). Among individuals with GSTM1 null and present genotypes, the corresponding ORs were 2.91 (95% CI, 0.44-19.09) and 4.21 (95% CI, 1.26-14...
  51. Zhuo W, Wang Y, Zhuo X, Zhu Y, Wang W, Zhu B, et al. CYP1A1 and GSTM1 polymorphisms and oral cancer risk: association studies via evidence-based meta-analyses. Cancer Invest. 2009;27:86-95 pubmed publisher
    Previous studies have implicated CYP1A1 and GSTM1 polymorphisms as risk factors for various cancers...
  52. Davies S, Bhatia S, Ross J, Kiffmeyer W, Gaynon P, Radloff G, et al. Glutathione S-transferase genotypes, genetic susceptibility, and outcome of therapy in childhood acute lymphoblastic leukemia. Blood. 2002;100:67-71 pubmed
    ..b>GSTM1 and GSTT1 genotypes are polymorphic in humans, and the phenotypic absence of enzyme activity is caused by a ..
  53. Sierra Torres C, Au W, Arrastia C, Cajas Salazar N, Robazetti S, Payne D, et al. Polymorphisms for chemical metabolizing genes and risk for cervical neoplasia. Environ Mol Mutagen. 2003;41:69-76 pubmed
    ..that environmental exposure to cigarette smoke and inheritance of polymorphic chemical metabolizing genes (CYP2E1, GSTM1, and mEH) significantly increase the risk for neoplasia...
  54. Kiyohara C, Wakai K, Mikami H, Sido K, Ando M, Ohno Y. Risk modification by CYP1A1 and GSTM1 polymorphisms in the association of environmental tobacco smoke and lung cancer: a case-control study in Japanese nonsmoking women. Int J Cancer. 2003;107:139-44 pubmed
    ..of both the activating and detoxifying enzymes, cytochrome P4501A1 (CYP1A1) and glutathione-S-transferase M1 (GSTM1), may be important as genetic factors. We conducted a multicenter case-control study in Japanese nonsmoking women...
  55. Suzen H, Guvenc G, Turanli M, Comert E, Duydu Y, Elhan A. The role of GSTM1 and GSTT1 polymorphisms in head and neck cancer risk. Oncol Res. 2007;16:423-9 pubmed
    ..b>GSTM1 and GSTT1 enzymes participate in detoxifying of tobacco smoke carcinogens and have deletion polymorphisms...
  56. Konwar R, Manchanda P, Chaudhary P, Nayak V, Singh V, Bid H. Glutathione S-transferase (GST) gene variants and risk of benign prostatic hyperplasia: a report in a North Indian population. Asian Pac J Cancer Prev. 2010;11:1067-72 pubmed
    ..The objective of this study was to determine relationships between polymorphisms in the GSTM1, T1 and P1 genes with risk of symptomatic BPH and response to standard therapy...
  57. Karami S, Boffetta P, Rothman N, Hung R, Stewart T, Zaridze D, et al. Renal cell carcinoma, occupational pesticide exposure and modification by glutathione S-transferase polymorphisms. Carcinogenesis. 2008;29:1567-71 pubmed publisher
    ..we also considered whether this association could be modified by glutathione S-transferase M1 and T1 (GSTM1 and GSTT1) genotypes...
  58. Kiran M, Chawla Y, Kaur J. Glutathione-S-transferase and microsomal epoxide hydrolase polymorphism and viral-related hepatocellular carcinoma risk in India. DNA Cell Biol. 2008;27:687-94 pubmed publisher
    ..The present study was undertaken to evaluate the association of GSTT1 and GSTM1 null genotypes and mEPHX polymorphisms with hepatitis virus-related HCC risk in an Indian population...
  59. Sergentanis T, Economopoulos K. GSTT1 and GSTP1 polymorphisms and breast cancer risk: a meta-analysis. Breast Cancer Res Treat. 2010;121:195-202 pubmed publisher
    Cytosolic glutathione S-transferase comprises multiple isoenzymes; studies have principally examined mu-1 (GSTM1: null/present), theta-1 (GSTT1: null/present) and pi-1 (GSTP1 Ile105Val) gene polymorphisms concerning breast cancer risk...
  60. Wikman H, Piirilä P, Rosenberg C, Luukkonen R, Kääriä K, Nordman H, et al. N-Acetyltransferase genotypes as modifiers of diisocyanate exposure-associated asthma risk. Pharmacogenetics. 2002;12:227-33 pubmed
    ..development of diisocyanate-induced ill effects, both separately and in combination with the previously examined GSTM1, GSTM3, GSTP1 and GSTT1 genotypes...
  61. Guo S. Glutathione S-transferases M1/T1 gene polymorphisms and endometriosis: a meta-analysis of genetic association studies. Mol Hum Reprod. 2005;11:729-43 pubmed
    ..surrounding the glutathione S-transferases (GST) M1/T1-endometriosis association, a meta-analysis of the GSTM1/GSTT1 genetic association studies of endometriosis was performed...
  62. Allan J, Wild C, Rollinson S, Willett E, Moorman A, Dovey G, et al. Polymorphism in glutathione S-transferase P1 is associated with susceptibility to chemotherapy-induced leukemia. Proc Natl Acad Sci U S A. 2001;98:11592-7 pubmed
    ..Functional polymorphisms exist in at least three genes that encode GSTs, including GSTM1, GSTT1, and GSTP1...
  63. To Figueras J, Gené M, Gomez Catalan J, Piqué E, Borrego N, Caballero M, et al. Microsomal epoxide hydrolase and glutathione S-transferase polymorphisms in relation to laryngeal carcinoma risk. Cancer Lett. 2002;187:95-101 pubmed
    ..epoxide hydrolase gene (EPHX1, 113Tyr-->113His, 139His-->139Arg) and four glutathione S-transferase genes (GSTM1, GSTM3, GSTP1, GSTT1) were genotyped in a group of patients with larynx cancer (N=204) and in a group of healthy ..
  64. Sgambato A, Campisi B, Zupa A, Bochicchio A, Romano G, Tartarone A, et al. Glutathione S-transferase (GST) polymorphisms as risk factors for cancer in a highly homogeneous population from southern Italy. Anticancer Res. 2002;22:3647-52 pubmed
    ..The GSTM1 and GSTT1 isoenzymes display several polymorphisms, including a homozygotic deletion, which have been associated ..
  65. Jhavar S, Sarin R, Mulherkar R, Benner A, Agarwal J, Dinshaw K. Glutathione S-transferase M1 or T1 null genotype as a risk factor for developing multiple primary neoplasms in the upper aero-digestive tract, in Indian males using tobacco. Oral Oncol. 2004;40:84-91 pubmed
    ..use, alcohol, radiotherapy for index cancer) and genetic parameters (family history of UADT cancers and GSTT1/GSTM1 genotype). The GSTM1/T1 null genotype, seen in 60% patients with MPN versus 33% patients with SPN (P=0...
  66. Tiemersma E, Voskuil D, Bunschoten A, Hogendoorn E, Witteman B, Nagengast F, et al. Risk of colorectal adenomas in relation to meat consumption, meat preparation, and genetic susceptibility in a Dutch population. Cancer Causes Control. 2004;15:225-36 pubmed
    ..6, 95% CI 1.1-2.3). In this Dutch population, unfavorable meat consumption and preparation habits did not increase colorectal adenoma risk, and these associations were not influenced by relevant genetic polymorphisms. ..
  67. Yildirim O, Ates N, Tamer L, Oz O, Yilmaz A, Atik U, et al. May glutathione S-transferase M1 positive genotype afford protection against primary open-angle glaucoma?. Graefes Arch Clin Exp Ophthalmol. 2005;243:327-33 pubmed
    To find out whether the polymorphism at GSTM1, GSTT1 and GSTP1 loci is associated with increased susceptibility to glaucoma. We genotyped 153 primary open angle patients and 159 healthy controls...
  68. Ahmad S, Arjumand W, Seth A, Kumar Saini A, Sultana S. Impact of glutathione transferase M1, T1, and P1 gene polymorphisms in the genetic susceptibility of North Indian population to renal cell carcinoma. DNA Cell Biol. 2012;31:636-43 pubmed publisher
    In this study, we investigated the association of GSTP1, GSTM1, and GSTP1 genetic variants with renal cell carcinoma (RCC) among North Indian patients...
  69. Chen H, Cao Y, Hu W, Liu X, Liu Q, Zhang J, et al. Genetic polymorphisms of phase II metabolic enzymes and lung cancer susceptibility in a population of Central South China. Dis Markers. 2006;22:141-52 pubmed
    ..The results showed that the frequencies of glutathione S-transferase (GST) M1-null (GSTM1-) or GSTT1-null (GSTT1-) genotype alone, or combined form of both in lung cancer patients were significantly ..
  70. Gilliland F, Li Y, Gong H, Diaz Sanchez D. Glutathione s-transferases M1 and P1 prevent aggravation of allergic responses by secondhand smoke. Am J Respir Crit Care Med. 2006;174:1335-41 pubmed
    ..We tested the hypotheses that functional GSTM1-null genotype and GSTP1 codon 105 variants (Ile105 and Val105) are determinants of allergic responses to SHS, and ..
  71. Lin Y, Hung S, Wei Y, Tarng D. GST M1 polymorphism associates with DNA oxidative damage and mortality among hemodialysis patients. J Am Soc Nephrol. 2009;20:405-15 pubmed publisher
    ..30 to 4.51) during the mean follow-up of 34 mo. In conclusion, patients without GST M1 activity are more vulnerable to oxidative stress and are at greater risk for death compared with those who possess GST M1 activity. ..
  72. Das P, Shaik A, Bammidi V. Meta-analysis study of glutathione-S-transferases (GSTM1, GSTP1, and GSTT1) gene polymorphisms and risk of acute myeloid leukemia. Leuk Lymphoma. 2009;50:1345-51 pubmed
    ..Overall, the random-effects OR with GSTM1 null genotype, GSTP1 Val105 allele and GSTT1 null genotype were 1.30 (95% confidence intervals (CI) 1.04-1...
  73. Luo Y, Chen H, Khan M, Chen F, Wan X, Tan B, et al. Genetic polymorphisms of metabolic enzymes-CYP1A1, CYP2D6, GSTM1, and GSTT1, and gastric carcinoma susceptibility. Tumour Biol. 2011;32:215-22 pubmed publisher
    ..cytochrome P450 1A1 (CYP1A1), CYP2D6 and phase II metabolic enzymes such as glutathione S-transferase M1 (GSTM1) and GSTT1 and gastric carcinoma susceptibility were investigated...
  74. Darazy M, Balbaa M, Mugharbil A, Saeed H, Sidani H, Abdel Razzak Z. CYP1A1, CYP2E1, and GSTM1 gene polymorphisms and susceptibility to colorectal and gastric cancer among Lebanese. Genet Test Mol Biomarkers. 2011;15:423-9 pubmed publisher
    ..The aim of this study was to investigate the relationship between CYP1A1, CYP2E1, and GSTM1 gene polymorphisms and GI cancer incidence among Lebanese...
  75. Infante Rivard C, Weinberg C, Guiguet M. Xenobiotic-metabolizing genes and small-for-gestational-age births: interaction with maternal smoking. Epidemiology. 2006;17:38-46 pubmed
    ..model were used to analyze the association between genetic variants such as CYP1A1*2A, CYP1A1*2B, CYP1A1*4, GSTT1, GSTM1, and XRCC3 and SGA. The interaction between genetic variants and maternal smoking was also studied...
  76. Saadat M, Farvardin Jahromi M, Saadat H. Null genotype of glutathione S-transferase M1 is associated with senile cataract susceptibility in non-smoker females. Biochem Biophys Res Commun. 2004;319:1287-91 pubmed
    In the present study, we investigated whether the polymorphisms of glutathione S-transferase M1 (GSTM1) and T1 (GSTT1) genes are risk factors of cataract among Iranian population in a molecular epidemiological way...
  77. Alexandrie A, Nyberg F, Warholm M, Rannug A. Influence of CYP1A1, GSTM1, GSTT1, and NQO1 genotypes and cumulative smoking dose on lung cancer risk in a Swedish population. Cancer Epidemiol Biomarkers Prev. 2004;13:908-14 pubmed
    ..We identified previously the possible modifying influence of CYP1A1 and GSTM1 polymorphisms on lung cancer risk in a Swedish population...
  78. Kidd L, Woodson K, Taylor P, Albanes D, Virtamo J, Tangrea J. Polymorphisms in glutathione-S-transferase genes (GST-M1, GST-T1 and GST-P1) and susceptibility to prostate cancer among male smokers of the ATBC cancer prevention study. Eur J Cancer Prev. 2003;12:317-20 pubmed
    ..Our observation of a relatively strong inverse association between the GST-M1-null genotype and prostate cancer risk needs to be confirmed in larger association studies. ..
  79. Kiyohara C, Yamamura K, Nakanishi Y, Takayama K, Hara N. Polymorphism in GSTM1, GSTT1, and GSTP1 and Susceptibility to Lung Cancer in a Japanese Population. Asian Pac J Cancer Prev. 2000;1:293-298 pubmed
    ..Three GST polymorphisms (GSTM1, GSTT1 and GSTP1) were determined among 86 male patients with lung carcinomas and 88 healthy male subjects...
  80. Zhu Y, He Q, Wang J, Pan H. The association between GSTM1 polymorphism and gastric cancer risk: a meta-analysis. Mol Biol Rep. 2012;39:685-91 pubmed publisher
    Relationship of gastric cancer with the GSTM1 polymorphism was reported with inconsistent results. The objective of this study was to quantitatively evaluate the association between GSTM1 polymorphism and gastric cancer susceptibility...
  81. Ozturk T, Kahraman O, Toptas B, Kisakesen H, Cakalir C, Verim L, et al. The effect of CYP1A1 and GSTM1 gene polymorphisms in bladder cancer development in a Turkish population. In Vivo. 2011;25:663-8 pubmed
    The aim of this study was to investigate a possible association of the CYP1A1 Ile462Val and GSTM1 null polymorphisms with the risk of developing bladder cancer in a Turkish population...