GLUT8

Summary

Gene Symbol: GLUT8
Description: solute carrier family 2 member 8
Alias: GLUT8, GLUTX1, solute carrier family 2, facilitated glucose transporter member 8, glucose transporter type 8, glucose transporter type X1, solute carrier family 2 (facilitated glucose transporter), member 8
Species: human

Top Publications

  1. ncbi Broiler chickens (Ross strain) lack insulin-responsive glucose transporter GLUT4 and have GLUT8 cDNA
    Yoshinori Seki
    Animal Nutrition, Division of Life Sciences, Graduate School of Agricultural Science, Tohoku University, Sendai 981 8555, Japan
    Gen Comp Endocrinol 133:80-7. 2003
  2. ncbi Characterisation of glucose transporter (GLUT) gene expression in broiler chickens
    T Kono
    Graduate School of Agricultural Science, Tohoku University, Sendai, Japan
    Br Poult Sci 46:510-5. 2005
  3. doi GLUT8, the enigmatic intracellular hexose transporter
    Stefan Schmidt
    Department of Pharmacology, German Institute of Human Nutrition Potsdam Rehbruecke, Arthur Scheunert Allee 114 116, D 14558 Nuthetal, Germany
    Am J Physiol Endocrinol Metab 296:E614-8. 2009
  4. ncbi Cytokine regulation of facilitated glucose transport in human articular chondrocytes
    A R Shikhman
    Division of Arthritis Research, The Scripps Research Institute, La Jolla, CA 92037, USA
    J Immunol 167:7001-8. 2001
  5. ncbi Biphasic effects of stress upon GLUT8 glucose transporter expression and trafficking in the diabetic rat hippocampus
    Gerardo G Piroli
    Harold and Margaret Milliken Hatch Laboratory of Neuroendocrinology, The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
    Brain Res 1006:28-35. 2004
  6. ncbi The glucose transporter families SGLT and GLUT: molecular basis of normal and aberrant function
    Andrea Scheepers
    Department of Pharmacology, German Institute of Human Nutrition Potsdam Rehbrucke, Nuthetal, Germany
    JPEN J Parenter Enteral Nutr 28:364-71. 2004
  7. ncbi Ontogenetic profile and thyroid hormone regulation of type-1 and type-8 glucose transporters in rat Sertoli cells
    Eleonora Carosa
    Course of Endocrinology and Medical Sexology, Department of Experimental Medicine, University of L Aquila, 67100 L Aquila, Italy
    Int J Androl 28:99-106. 2005
  8. pmc GLUT8 is dispensable for embryonic development but influences hippocampal neurogenesis and heart function
    Mathieu Membrez
    Institute of Physiology, University of Lausanne, Center for Integrative Genomics, Genopode Building, CH 1015 Lausanne, Switzerland
    Mol Cell Biol 26:4268-76. 2006
  9. doi Expression of GLUT8 in mouse intestine: identification of alternative spliced variants
    Amparo Romero
    Department of Physiology, Pharmacology and Toxicology, Experimental Sciences and Health Faculty, University CEU Cardenal Herrera, E 46113 Moncada, Valencia, Spain
    J Cell Biochem 106:1068-78. 2009
  10. ncbi 196 effects of different in vitro maturation systems on bovine embryo development
    S M Bernal
    Institute of Farm Animal Genetics, Friedrich Loeffler Institut, Mariensee, Germany
    Reprod Fertil Dev 24:210. 2011

Research Grants

  1. THE EFFECT OF DIOXINS ON GLUCOSE HOMEOSTASIS IN MURINE TESTES
    KENAN RIFAT OMURTAG; Fiscal Year: 2013
  2. GLUTS AND GLUCOSE TRANSPORT IN THE MOUSE BLASTOCYST
    Kelle H Moley; Fiscal Year: 2012
  3. GLUT8 Overexpression in Cardioprotection
    Maureen J Charron; Fiscal Year: 2010
  4. Glucose Meatbolism in the Human Ovary
    MAUREEN CHARRON; Fiscal Year: 2004
  5. IGF INDUCED TOXICITY IN PREIMPLANTATION EMBRYOS
    Kelle Moley; Fiscal Year: 2007
  6. Regulation of Cardiac Glucose Transporters
    MAUREEN CHARRON; Fiscal Year: 2007
  7. Development of Diabetic Cardiomyopathy in GLUT4 +/- Mice
    MAUREEN CHARRON; Fiscal Year: 2004
  8. Molecular Aspects of Implantation
    Kelle Moley; Fiscal Year: 2006
  9. Maternal Diabetes and Oocyte Quality
    Kelle Moley; Fiscal Year: 2007
  10. REGULATION OF MESANGIAL CELL ECM SYNTHESIS BY GLUT1
    Charles Heilig; Fiscal Year: 2002

Scientific Experts

  • J R Aschenbach
  • Feng qi Zhao
  • Charles A Stuart
  • E Warzych
  • Daichi Ijiri
  • Leszek Szablewski
  • Mei Sian Chong
  • Kelle H Moley
  • L P Reagan
  • R Augustin
  • Vishal Saxena
  • I Stuart Wood
  • Bruce K Campbell
  • A Schurmann
  • T A D Smith
  • Hans Georg Joost
  • Michael von Wolff
  • Charles Heilig
  • MAUREEN CHARRON
  • Maureen J Charron
  • Sung Tae Kim
  • Olga Gomez
  • Brian J DeBosch
  • KENAN RIFAT OMURTAG
  • S M Bernal
  • D Herrmann
  • H Niemann
  • Jose Terrado
  • Jose E Mesonero
  • Sachiko Futakuchi
  • Stefan Schmidt
  • Hadi Al-Hasani
  • Amitabh Krishna
  • M A Velazquez
  • Maggie Chi
  • Anne Navarrete Santos
  • Verena Gawlik
  • Amparo Romero
  • Rachna Verma
  • Saki Shimamoto
  • Chelsie B Steinhauser
  • Sandra Milena Bernal-Ulloa
  • Allyson L Mayer
  • Gerardo G Piroli
  • H Doege
  • Ellen E Jackson
  • C S Harrell
  • - Anuradha
  • Mary O Carayannopoulos
  • Andrea Scheepers
  • K W Cho
  • Christopher P Corpe
  • Y Shao
  • Marta Wasielak
  • A Lucas-Hahn
  • Samuel K McBrayer
  • K Zhao
  • J Heinzmann
  • Katie L Adastra
  • Bernard Thorens
  • Daniele Campa
  • Lauren B Aerni-Flessner
  • T Somfai
  • Karen K Yee
  • Vikas Kumar Roy
  • Tamas Somfai
  • S T Kim
  • Begoña Ballester-Lurbe
  • J Zaraza
  • Anthony J Cura
  • A Scheepers
  • Daoliang Lan
  • Y Zhao
  • Binbing Ling
  • Ying Song
  • Martin C Steward
  • Hiroshi Ishiguro
  • Miyuki Nakakuki
  • Philippe Fonteyne
  • Muhammed Kasim Diril
  • Lauren B Flessner
  • Kotoyo Fujiki
  • Akiko Yamamoto
  • O Gomez
  • Shigeru B H Ko
  • Hidemi Goto
  • Takaharu Kondo
  • Paul W Hruz
  • Satoru Naruse
  • S Schmidt

Detail Information

Publications103 found, 100 shown here

  1. ncbi Broiler chickens (Ross strain) lack insulin-responsive glucose transporter GLUT4 and have GLUT8 cDNA
    Yoshinori Seki
    Animal Nutrition, Division of Life Sciences, Graduate School of Agricultural Science, Tohoku University, Sendai 981 8555, Japan
    Gen Comp Endocrinol 133:80-7. 2003
    Identification of insulin-responsive glucose transporter proteins, GLUT4 and GLUT8, was attempted in chickens that characteristically are hyperglycemic and insulin resistant...
  2. ncbi Characterisation of glucose transporter (GLUT) gene expression in broiler chickens
    T Kono
    Graduate School of Agricultural Science, Tohoku University, Sendai, Japan
    Br Poult Sci 46:510-5. 2005
    ..The aim of this study was to identify the extent of mRNA expression of GLUT1, GLUT2, GLUT3 and GLUT8 in chickens intrinsically lacking GLUT4. 2...
  3. doi GLUT8, the enigmatic intracellular hexose transporter
    Stefan Schmidt
    Department of Pharmacology, German Institute of Human Nutrition Potsdam Rehbruecke, Arthur Scheunert Allee 114 116, D 14558 Nuthetal, Germany
    Am J Physiol Endocrinol Metab 296:E614-8. 2009
    b>GLUT8 is a class III sugar transporter predominantly expressed in testis and brain...
  4. ncbi Cytokine regulation of facilitated glucose transport in human articular chondrocytes
    A R Shikhman
    Division of Arthritis Research, The Scripps Research Institute, La Jolla, CA 92037, USA
    J Immunol 167:7001-8. 2001
    ..GLUT3 and GLUT8 mRNA are constitutively expressed in chondrocytes and are not regulated by IL-1beta...
  5. ncbi Biphasic effects of stress upon GLUT8 glucose transporter expression and trafficking in the diabetic rat hippocampus
    Gerardo G Piroli
    Harold and Margaret Milliken Hatch Laboratory of Neuroendocrinology, The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
    Brain Res 1006:28-35. 2004
    ..effects of stress, streptozotocin (STZ)-induced diabetes and the combined actions of stress and hyperglycemia upon GLUT8 mRNA expression, protein levels and intracellular trafficking in the rat hippocampus...
  6. ncbi The glucose transporter families SGLT and GLUT: molecular basis of normal and aberrant function
    Andrea Scheepers
    Department of Pharmacology, German Institute of Human Nutrition Potsdam Rehbrucke, Nuthetal, Germany
    JPEN J Parenter Enteral Nutr 28:364-71. 2004
    ..Furthermore, some transporters (eg, GLUT4 and GLUT8) are regulated by their subcellular distribution...
  7. ncbi Ontogenetic profile and thyroid hormone regulation of type-1 and type-8 glucose transporters in rat Sertoli cells
    Eleonora Carosa
    Course of Endocrinology and Medical Sexology, Department of Experimental Medicine, University of L Aquila, 67100 L Aquila, Italy
    Int J Androl 28:99-106. 2005
    ..The aim of this paper is to investigate the expression profile of GLUT1 and GLUT8 in the testis during development and in adulthood and analyse the role of T(3) on their expression...
  8. pmc GLUT8 is dispensable for embryonic development but influences hippocampal neurogenesis and heart function
    Mathieu Membrez
    Institute of Physiology, University of Lausanne, Center for Integrative Genomics, Genopode Building, CH 1015 Lausanne, Switzerland
    Mol Cell Biol 26:4268-76. 2006
    b>GLUT8 is a glucose transporter isoform expressed at high levels in testis; at intermediate levels in the brain, including the hippocampus; and at lower levels in the heart and several other tissues...
  9. doi Expression of GLUT8 in mouse intestine: identification of alternative spliced variants
    Amparo Romero
    Department of Physiology, Pharmacology and Toxicology, Experimental Sciences and Health Faculty, University CEU Cardenal Herrera, E 46113 Moncada, Valencia, Spain
    J Cell Biochem 106:1068-78. 2009
    b>GLUT8 is a facilitative glucose transporter composed of 10 exons coding for a 477 amino acids protein. It is mainly expressed in the testis, but it has also been studied in a number of tissues such as brain, adipose tissue, and liver...
  10. ncbi 196 effects of different in vitro maturation systems on bovine embryo development
    S M Bernal
    Institute of Farm Animal Genetics, Friedrich Loeffler Institut, Mariensee, Germany
    Reprod Fertil Dev 24:210. 2011
    ..Results so far indicate that the method of obtaining the oocytes (slicing vs aspiration) for in vitro production of bovine embryos is of greater influence on blastocyst quality than IVM conditions...
  11. pmc Slc2a8 deficiency in mice results in reproductive and growth impairments
    Katie L Adastra
    Department of Obstetrics and Gynecology, Washington University School of Medicine, St Louis, Missouri, USA
    Biol Reprod 87:49. 2012
    SLC2A8, also known as GLUT8, is a facilitative glucose transporter expressed in the testis, brain, liver, heart, uterus, ovary, and fat...
  12. doi 163 effects of different in vitro maturation systems on embryo development in bovine prepubertal and adult donors
    S M Bernal
    Institute of Farm Animal Genetics, Biotechnology, Friedrich Loeffler Institut FLI, Mariensee, Germany
    Reprod Fertil Dev 26:195. 2013
    ..These preliminary results indicate that oocyte developmental capacity in prepubertal donors can be similar to that of the adult donors without addition of cAMP modulators. ..
  13. doi Ovarian steroids influence cerebral glucose transporter expression in a region- and isoform-specific pattern
    C S Harrell
    Department of Physiology, Emory University, Atlanta, GA, USA
    J Neuroendocrinol 26:217-25. 2014
    ....
  14. doi Role of adiponectin in delayed embryonic development of the short-nosed fruit bat, Cynopterus sphinx
    - Anuradha
    Departmentof Zoology, Banaras Hindu University, Varanasi, India
    Mol Reprod Dev 81:1086-102. 2014
    ..PCNA levels together with increased uptake of glucose by increasing the abundance of glucose transporter 8 (GLUT8) in the utero-embryonic unit...
  15. pmc Loss of Toll-Like Receptor 4 Function Partially Protects against Peripheral and Cardiac Glucose Metabolic Derangements During a Long-Term High-Fat Diet
    Ellen E Jackson
    Department of Physiological Sciences, Oklahoma State University, Stillwater, Oklahoma, United States of America
    PLoS ONE 10:e0142077. 2015
    ..TLR4-mutant mice fed a HFD also had increased expression of GLUT8, a novel isoform, compared to mice fed a normal diet...
  16. pmc Cyclic AMP Affects Oocyte Maturation and Embryo Development in Prepubertal and Adult Cattle
    Sandra Milena Bernal-Ulloa
    Institute of Farm Animal Genetics, Biotechnology, Friedrich Loeffler Institut, Mariensee, Germany
    PLoS ONE 11:e0150264. 2016
    ..These data indicate that cAMP regulates IVM in prepubertal and adult oocytes in a similar manner, with impact on the establishment of epigenetic marks and acquisition of full developmental competency...
  17. doi Effect of Letrozole, a selective aromatase inhibitor, on testicular activities in adult mice: Both in vivo and in vitro study
    Rachna Verma
    Department of Zoology, Banaras Hindu University, Varanasi 221005, India
    Gen Comp Endocrinol 241:57-68. 2017
    ..The decreased effects of insulin inhibited the glucose transport in the testis by suppressing GLUT8. The decreased level of testicular glucose may produce less lactate as energy support to developing germ cells ..
  18. doi Gene expression pattern of glucose transporters in the skeletal muscles of newly hatched chicks
    Saki Shimamoto
    a Department of Biochemical Science and Technology, Kagoshima University, Kagoshima, Japan
    Biosci Biotechnol Biochem 80:1382-5. 2016
    The gene expression pattern of the glucose transporters (GLUT1, GLUT3, GLUT8, and GLUT12) among pectoralis major and minor, biceps femoris, and sartorius muscles from newly hatched chicks was examined...
  19. ncbi Fructose Synthesis and Transport at the Uterine-Placental Interface of Pigs: Cell-Specific Localization of SLC2A5, SLC2A8, and Components of the Polyol Pathway
    Chelsie B Steinhauser
    Department of Veterinary Integrative Biosciences, Texas A and M University, College Station, Texas
    Biol Reprod 95:108. 2016
    ....
  20. doi Prepubertal heifers versus cows-The differences in the follicular environment
    E Warzych
    Department of Genetics and Animal Breeding, Poznan University of Life Sciences, Poznan, Poland Electronic address
    Theriogenology 87:36-47. 2017
    ..in energy metabolism (fatty acids [FAs] metabolism-ELOVL2, ELOVL5, SCD, FADS2, glucose transport-GLUT1, GLUT3, GLUT8) in CC and GC as well as FA composition and glucose concentration in FF...
  21. pmc SLC2A8 (GLUT8) is a mammalian trehalose transporter required for trehalose-induced autophagy
    Allyson L Mayer
    Department of Pediatrics, Washington University School of Medicine, 660 S Euclid Ave, St Louis, MO 63110, USA
    Sci Rep 6:38586. 2016
    ..fluorescence microscopic and radiolabeled uptake evidence that trehalose traverses the plasma membrane via SLC2A8 (GLUT8), a homolog of the trehalose transporter-1 (Tret1)...
  22. ncbi Expression and regulation of glucose transporter 8 in rat Leydig cells
    Y Chen
    Research Services, WJB Dorn Veterans Medical Center, Columbia, South Carolina 29201, USA
    J Endocrinol 179:63-72. 2003
    ..Recently, glucose transporter 8 (GLUT8) has been shown to be highly expressed in the testis...
  23. ncbi Glucose transporter GLUT8 translocation in neurons is not insulin responsive
    Bo Chul Shin
    Department of Pediatrics, David Geffen School of Medicine at UCLA, Los Angeles, California 90095 1752, USA
    J Neurosci Res 75:835-44. 2004
    We examined the subcellular distribution of a novel glucose transporter isoform (GLUT8) in murine N2A neuroblastoma cells...
  24. ncbi Two insulin-responsive glucose transporter isoforms and the insulin receptor are developmentally expressed in rabbit preimplantation embryos
    Anne Navarrete Santos
    Department of Anatomy and Cell Biology, Martin Luther University Faculty of Medicine, Grosse Steinstrasse 52, D 06108 Halle Saale, Germany
    Reproduction 128:503-16. 2004
    ..GLUT4 is expressed in bovine preimplantation embryos. A new insulin-responsive isoform, GLUT8, was recently described in mouse blastocysts...
  25. ncbi Insulin acts via mitogen-activated protein kinase phosphorylation in rabbit blastocysts
    Anne Navarrete Santos
    Department of Anatomy and Cell Biology, Martin Luther University Faculty of Medicine, Grosse Steinstrasse 52, D 06108 Halle Saale, Germany
    Reproduction 128:517-26. 2004
    ..In the present study, the effects of 170 nM insulin on IR, GLUT4 and GLUT8 mRNA levels, Akt and Erk phosphorylation, GLUT4 translocation and methyl glucose transport were studied in ..
  26. ncbi Positherapy: targeted nuclear therapy of breast cancer with 18F-2-deoxy-2-fluoro-D-glucose
    Renee M Moadel
    Department of Nuclear Medicine, Albert Einstein College of Medicine, 1695A Eastchester Road, Bronx, NY 10461, USA
    Cancer Res 65:698-702. 2005
    ..Substantial differences between GLUT1, GLUT4, and GLUT8 were observed in their distribution within the tumor mass...
  27. ncbi Changes in gene expression involved in energy utilization during chicken follicle development
    H S Seol
    Animal Nutrition, Division of Life Sciences, Graduate School of Agricultural Science, Tohoku University, Sendai 981 8555, Japan
    Anim Reprod Sci 95:283-94. 2006
    ..GLUT) isoform expression, the level of GLUT1 mRNA increased with follicle development while GLUT2, GLUT3 and GLUT8 mRNA levels were unaffected by follicle development...
  28. ncbi GLUT8 contains a [DE]XXXL[LI] sorting motif and localizes to a late endosomal/lysosomal compartment
    Robert Augustin
    Institute for Human Nutrition, Department of Pharmacology, 14482 Potsdam Rehbrücke, Germany
    Traffic 6:1196-212. 2005
    Glucose transporter 8 (GLUT8) contains a cytoplasmic N-terminal dileucine motif and localizes to a thus far unidentified intracellular compartment...
  29. ncbi Glucose transporter 8 (GLUT8) from the red imported fire ant, Solenopsis invicta Buren (Hymenoptera: Formicidae)
    Mei Er Chen
    Department of Entomology, Texas A and M University, College Station, 77843 2475, USA
    Arch Insect Biochem Physiol 62:55-72. 2006
    We have cloned the fire ant glucose transporter 8 (GLUT8) cDNA providing the first molecular characterization of a GLUT8 in insects. Glucose is a poly-alcohol and, due to its high hydrophilicity, cannot move across cell membranes...
  30. pmc Intestinal dehydroascorbic acid (DHA) transport mediated by the facilitative sugar transporters, GLUT2 and GLUT8
    Christopher P Corpe
    Molecular and Clinical Nutrition Section, Digestive Diseases Branch, Intramural Research Program, NIDDK, National Institutes of Health, Bethesda, MD 20892 1372, USA
    J Biol Chem 288:9092-101. 2013
    ..Only GLUT2 and GLUT8, known to be expressed in intestines, transported DHA with apparent transport affinities (Km) of 2.33 and 3...
  31. pmc Glucose transporter-8 (GLUT8) mediates glucose intolerance and dyslipidemia in high-fructose diet-fed male mice
    Brian J DeBosch
    MD, Department of Obstetrics and Gynecology, Washington University in St Louis School of Medicine, 660 South Euclid Avenue, St Louis, MO 63110
    Mol Endocrinol 27:1887-96. 2013
    ..evidence suggests that the ubiquitously expressed class III dual-specificity glucose and fructose transporter, GLUT8, has important metabolic homeostatic functions...
  32. ncbi Differential expression of glucose transporter GLUT8 during mouse spermatogenesis
    Olga Gomez
    Department of Medicine and Animal Surgery, Experimental Sciences and Health Faculty, Cardenal Herrera CEU University, E 46113 Moncada, Valencia, Spain
    Reproduction 131:63-70. 2006
    b>GLUT8 is a facilitative glucose transporter expressed at high levels in the testis. In this study, we analyzed the GLUT8 expression in mouse testis during spermatogenesis by RT-PCR, Western blot and immunohistochemistry methods...
  33. doi Identification of a pivotal endocytosis motif in c-Met and selective modulation of HGF-dependent aggressiveness of cancer using the 16-mer endocytic peptide
    K W Cho
    Aging Research Center, Korea Research Institute of Bioscience and Biotechnology, Daejeon, Korea
    Oncogene 32:1018-29. 2013
    ..of interleukin-2 receptor α-subunit/3S chimeric protein, but not the other receptors, including Glut4, Glut8 and transferrin receptor. Such results indicate the presence of a selective endocytic assembly for c-Met...
  34. pmc Glucose transporter 8 (GLUT8) regulates enterocyte fructose transport and global mammalian fructose utilization
    Brian J DeBosch
    Department of Pediatrics, Washington University in St Louis School of Medicine, 660 South Euclid Avenue, St Louis, Missouri 63110, USA
    Endocrinology 153:4181-91. 2012
    ..The in vivo function of GLUT8, however, remains unclear...
  35. doi Lactogenic hormones stimulate expression of lipogenic genes but not glucose transporters in bovine mammary gland
    Y Shao
    Department of Animal Science, University of Vermont, Burlington, VT 05405, USA
    Domest Anim Endocrinol 44:57-69. 2013
    ..1 (SREBF1), fatty acid synthase (FASN), acetyl-CoA carboxylase α (ACACA), stearyol-CoA desaturase (SCD), GLUT1, GLUT8, and GLUT12 were measured by real-time PCR...
  36. doi Transcript abundance and apoptosis in day-7 porcine blastocyst cultured with exogenous insulin-like growth factor-I
    Marta Wasielak
    Institute of Animal Reproduction and Food Research of Polish Academy of Sciences, Olsztyn, Poland
    Reprod Biol 13:58-65. 2013
    ..This may indicate that the primary role of IGF-I during the first days of embryo development in the pig is associated with anti-apoptotic actions rather than with growth stimulation...
  37. ncbi The effect of ovary storage and in vitro maturation on mRNA levels in bovine oocytes; a possible impact of maternal ATP1A1 on blastocyst development in slaughterhouse-derived oocytes
    Tamas Somfai
    National Institute of Livestock and Grassland Science, National Agriculture and Food Research Organization, Ibaraki 305 0901, Japan jp
    J Reprod Dev 57:723-30. 2011
    ..In immature OPU oocytes, genes related to metabolism (GAPDH), transporters (GLUT8, ATP1A1) and stress resistance protein (HSP70) showed significantly higher expression compared with oocytes ..
  38. ncbi 138 THE EFFECT OF FOLLICLE SUPERSTIMULATION ON mRNA LEVELS IN BOVINE OOCYTES COLLECTED BY OVUM PICKUP
    T Somfai
    National Institute of Livestock and Grassland Science, National Agriculture and Food Research Organization, Tsukuba, Ibaraki, Japan
    Reprod Fertil Dev 24:181-2. 2011
    ..The following genes were investigated: GAPDH, G6PDH, ACTB, H2A, CCNB1, MnSOD, OCT4, SOX2, CX43, HSP70, GLUT8, PAP, GDF9, COX1, ATP1A1, CDH1, CTNNB1, AQP3, DYNLL1, DYNC 1/1 and PMSB1...
  39. doi Effect of glucose availability on glucose transport in bovine mammary epithelial cells
    K Zhao
    Institute of Dairy Science, MOE Key Laboratory of Molecular Animal Nutrition, College of Animal Sciences, Zhejiang University, Hangzhou 310029, PR China
    Animal 6:488-93. 2012
    ..05), whereas 20 mM glucose decreased the GLUT1 mRNA expression in the BMEC (P < 0.05). The expression of GLUT8 mRNA was not affected by any concentration of glucose (P > 0.05)...
  40. pmc Multiple myeloma exhibits novel dependence on GLUT4, GLUT8, and GLUT11: implications for glucose transporter-directed therapy
    Samuel K McBrayer
    Division of Hematology, Robert H Lurie Comprehensive Cancer Center, Feinberg School of Medicine, Northwestern University, 303 E Superior St, Chicago, IL 60611, USA
    Blood 119:4686-97. 2012
    ..We also establish that the activities of the enigmatic transporters GLUT8 and GLUT11 are required for proliferation and viability in myeloma, albeit because of functionalities probably ..
  41. doi In vivo oocyte IGF-1 priming increases inner cell mass proliferation of in vitro-formed bovine blastocysts
    M A Velazquez
    Institute of Farm Animal Genetics, Biotechnology, Friedrich Loeffler Institut, Höltystraße 10, Mariensee, 31535 Neustadt, Germany
    Theriogenology 78:517-27. 2012
    ..Results show that even a short in vivo exposure of oocytes to a supraphysiological IGF-1 microenvironment can increase ICM cell proliferation in vitro during the morula to blastocyst transition...
  42. ncbi GLUTX1, a novel mammalian glucose transporter expressed in the central nervous system and insulin-sensitive tissues
    M Ibberson
    Institute of Pharmacology and Toxicology, Rue du Bugnon 27, 1005 Lausanne, Switzerland
    J Biol Chem 275:4607-12. 2000
    Based on homology with GLUT1-5, we have isolated a cDNA for a novel glucose transporter, GLUTX1. This cDNA encodes a protein of 478 amino acids that shows between 29 and 32% identity with rat GLUT1-5 and 32-36% identity with plant and ..
  43. ncbi GLUT8, a novel member of the sugar transport facilitator family with glucose transport activity
    H Doege
    Institute of Pharmacology and Toxicology, Medical Faculty, Technical University of Aachen, D 52057 Aachen, Germany
    J Biol Chem 275:16275-80. 2000
    b>GLUT8 is a novel glucose transporter-like protein that exhibits significant sequence similarity with the members of the sugar transport facilitator family (29.4% of amino acids identical with GLUT1). Human and mouse sequence (86...
  44. pmc GLUT8 is a glucose transporter responsible for insulin-stimulated glucose uptake in the blastocyst
    M O Carayannopoulos
    Department of Obstetrics and Gynecology, 4911 Barnes Jewish Hospital Plaza, St Louis, MO 63110, USA
    Proc Natl Acad Sci U S A 97:7313-8. 2000
    ..Moreover, the existence of an alternative transporter may explain examples in other tissues of insulin-regulated glucose transport in the absence of GLUT4...
  45. pmc Activity and genomic organization of human glucose transporter 9 (GLUT9), a novel member of the family of sugar-transport facilitators predominantly expressed in brain and leucocytes
    H Doege
    Institut fur Pharmakologie und Toxikologie, Medizinische Fakultat der RWTH Aachen, Wendlingweg 2, D 52057 Aachen, Germany
    Biochem J 350:771-6. 2000
    ..The next relative of GLUT9 is the glucose transporter GLUT8/GLUTX1 (44.8% amino acid identity with GLUT9). A 2...
  46. pmc Localization and regulation of GLUTx1 glucose transporter in the hippocampus of streptozotocin diabetic rats
    L P Reagan
    Harold and Margaret Milliken Hatch Laboratory of Neuroendocrinology, The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA
    Proc Natl Acad Sci U S A 98:2820-5. 2001
    We describe the localization of the recently identified glucose transporter GLUTx1 and the regulation of GLUTx1 in the hippocampus of diabetic and control rats...
  47. ncbi Glucose transporter expression is developmentally regulated in in vitro derived bovine preimplantation embryos
    R Augustin
    Department of Anatomy and Cell Biology, Martin Luther University Faculty of Medicine, Grosse Steinstrasse 52, D 06097 Halle Saale, Germany
    Mol Reprod Dev 60:370-6. 2001
    ..The embryos were produced in vitro by IVM-IVF. Glut1, Glut3, Glut8, and SGLT-I were expressed in all stages studied. Glut4 transcripts were first detected at the blastocyst stage...
  48. ncbi Mouse GLUT8: genomic organization and regulation of expression in 3T3-L1 adipocytes by glucose
    A Scheepers
    Institute of Pharmacology and Toxicology, Technical University of Aachen, Aachen, D 52057, Germany
    Biochem Biophys Res Commun 288:969-74. 2001
    Glucose transporter 8 (GLUT8) is a class III sugar transport facilitator predominantly expressed in testis and insulin-regulated tissues...
  49. ncbi Immunolocalization of GLUTX1 in the testis and to specific brain areas and vasopressin-containing neurons
    Mark Ibberson
    Institute of Pharmacology and Toxicology, University of Lausanne, 27 rue du Bugnon, 1005 Lausanne, Switzerland
    Endocrinology 143:276-84. 2002
    b>GLUTX1 or GLUT8 is a newly characterized glucose transporter isoform that is expressed at high levels in the testis and brain and at lower levels in several other tissues...
  50. ncbi The extended GLUT-family of sugar/polyol transport facilitators: nomenclature, sequence characteristics, and potential function of its novel members (review)
    H G Joost
    Institute of Pharmacology and Toxicology, Medical Faculty, Technical University of Aachen, Germany
    Mol Membr Biol 18:247-56. 2001
    ..Like GLUT1-4, they exhibit a tissue/cell-specific expression (GLUT6, leukocytes, brain; GLUT8, testis, blastocysts, brain, muscle, adipocytes; GLUT9, liver, kidney; GLUT10, liver, pancreas; GLUT11, heart, ..
  51. ncbi GLUT8 glucose transporter is localized to excitatory and inhibitory neurons in the rat hippocampus
    Lawrence P Reagan
    Harold and Margaret Milliken Hatch Laboratory of Neuroendocrinology, The Rockefeller University, Box 165, 1230 York Avenue, New York, NY 10021, USA
    Brain Res 932:129-34. 2002
    Fluorescence immunohistochemistry was performed to characterize the distribution and phenotype of GLUT8-positive neurons in rat brain and to compare the cellular distribution of GLUT8 with GLUT3 in the hippocampus...
  52. ncbi Indinavir inhibits the glucose transporter isoform Glut4 at physiologic concentrations
    Haruhiko Murata
    Department of Cell Biology and Physiology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    AIDS 16:859-63. 2002
    ..To determine the relative sensitivities of glucose transporter isoforms to the protease inhibitor indinavir and to determine the kinetic mechanism of indinavir-mediated Glut4 isoform inhibition...
  53. ncbi Immunohistochemical localization and quantification of glucose transporters in the mouse brain
    C Choeiri
    School of Psychology, University of Ottawa, Vanier Building, Room 202, Ottawa, ON, Canada K1N 6N5
    Neuroscience 111:19-34. 2002
    ..In the brain, Glut2, Glut5 and Glut8 are found at relatively low levels whereas Glut1, Glut3 and Glut4 were reported in abundance in several brain ..
  54. ncbi Glucose transporter 8 expression and translocation are critical for murine blastocyst survival
    Anil B Pinto
    Department of Obstetrics and Gynecology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Biol Reprod 66:1729-33. 2002
    ..To determine the physiologic role of GLUT8, two-cell embryos were cultured to a blastocyst stage in antisense or sense oligonucleotides to GLUT8...
  55. ncbi Peripheral glucose administration stimulates the translocation of GLUT8 glucose transporter to the endoplasmic reticulum in the rat hippocampus
    Gerardo G Piroli
    Harold and Margaret Milliken Hatch Laboratory of Neuroendocrinology, The Rockefeller University, New York, NY 10021, USA
    J Comp Neurol 452:103-14. 2002
    ..The recently identified glucose transporter GLUT8 is uniquely expressed in neuronal cell bodies in the rat hippocampus and therefore may contribute to hippocampal ..
  56. ncbi Insulin-responsive glucose transporters-GLUT8 and GLUT4 are expressed in the developing mammalian brain
    Raman Sankar
    Department of Pediatrics, UCLA School of Medicine, Los Angeles, CA 90095 1752, USA
    Brain Res Mol Brain Res 107:157-65. 2002
    ..the spatial and temporal distribution of insulin-responsive facilitative glucose transporter isoforms GLUT4 and GLUT8 in the developing mouse brain...
  57. ncbi Molecular characterization and partial cDNA cloning of facilitative glucose transporters expressed in human articular chondrocytes; stimulation of 2-deoxyglucose uptake by IGF-I and elevated MMP-2 secretion by glucose deprivation
    S Richardson
    Connective Tissue Research Group, Department of Veterinary Preclinical Sciences, Faculty of Veterinary Science, University of Liverpool, UK
    Osteoarthritis Cartilage 11:92-101. 2003
    ....
  58. ncbi Glucose transporters (GLUT and SGLT): expanded families of sugar transport proteins
    I Stuart Wood
    Liverpool Centre for Nutritional Genomics, Neuroendocrine and Obesity Biology Unit, Department of Medicine, UK
    Br J Nutr 89:3-9. 2003
    ..the presence of several different transporters in certain tissues and cells (for example, GLUT1, GLUT4, GLUT5, GLUT8, GLUT12 and HMIT in white adipose tissue), indicates that glucose delivery into cells is a process of considerable ..
  59. ncbi Regulation of hepatic GLUT8 expression in normal and diabetic models
    Naira Gorovits
    Department of Biochemistry, Albert Einstein College of Medicine, Bronx, New York 10461, USA
    Endocrinology 144:1703-11. 2003
    b>GLUT8 is a novel glucose transporter protein that is widely distributed in tissues including liver, a central organ of regulation of glucose homeostasis...
  60. ncbi Mitogenic and anti-apoptotic activity of insulin on bovine embryos produced in vitro
    R Augustin
    Department of Anatomy and Cell Biology, Martin Luther University Faculty of Medicine, Halle Saale, Germany
    Reproduction 126:91-9. 2003
    ..and by quantification of the relative amounts of mRNA for Bax and Bcl-XL; and (iv) expression for Glut1, Glut3 and Glut8 transcripts was compared between embryos cultured in the presence or absence of insulin...
  61. ncbi Syntaxin 4 expression affects glucose transporter 8 translocation and embryo survival
    Amanda Hoehn Wyman
    Department of Obstetrics and Gynecology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Mol Endocrinol 17:2096-102. 2003
    ..b>GLUT8 is a novel IGF-I/insulin-regulated glucose transporter expressed in the mouse blastocyst...
  62. ncbi Glucose transporter proteins (GLUT) in human endometrium: expression, regulation, and function throughout the menstrual cycle and in early pregnancy
    Michael von Wolff
    Department of Gynecological Endocrinology and Reproductive Medicine, University of Heidelberg, 69115 Heidelberg, Germany
    J Clin Endocrinol Metab 88:3885-92. 2003
    ..isoforms are expressed, whereas glucose transporters, involved in insulin-dependent glucose uptake (GLUT2, GLUT4, GLUT8), could not be detected...
  63. pmc Implications of glucose transporter protein type 1 (GLUT1)-haplodeficiency in embryonic stem cells for their survival in response to hypoxic stress
    Charles Heilig
    Division of Nephrology, Johns Hopkins University School of Medicine, 720 Rutland Avenue, Ross 947, Baltimore, MD 21205, USA
    Am J Pathol 163:1873-85. 2003
    ..GLUT3 was unchanged. GLUT8 and GLUT12 were also expressed and unchanged in GT1(+/-)...
  64. ncbi GLUT11, but not GLUT8 or GLUT12, is expressed in human skeletal muscle in a fibre type-specific pattern
    M Gaster
    Department of Endocrinology, Odense University Hospital, 5000 Odense, Denmark
    Pflugers Arch 448:105-13. 2004
    ..The mRNA for three of these, the glucose transporters (GLUT) GLUT8, GLUT11 and GLUT12, have been detected in human skeletal muscle...
  65. ncbi Characterization of glucose transporter 8 (GLUT8) in the ovine placenta of normal and growth restricted fetuses
    S W Limesand
    Perinatal Research Center, Department of Pediatrics, University of Colorado Health Sciences Center, 13243 East 23rd Avenue, Aurora, CO 80010, USA
    Placenta 25:70-7. 2004
    ..The objective of this study was to characterize GLUT8 in the ovine placenta and determine if differences in mRNA and protein concentrations occur in an ovine model of ..
  66. ncbi Bovine glucose transporter GLUT8: cloning, expression, and developmental regulation in mammary gland
    Feng qi Zhao
    Lactation and Mammary Gland Biology Group, Department of Animal Science, University of Vermont, Burlington, Vermont 05405, USA
    Biochim Biophys Acta 1680:103-13. 2004
    b>GLUT8 is a newly identified member of the facilitative glucose transporter family, which characteristically exhibits high-affinity glucose transport activity...
  67. ncbi Localization of the GLUT8 glucose transporter in murine kidney and regulation in vivo in nondiabetic and diabetic conditions
    Mario Schiffer
    Division of Nephrology, Albert Einstein College of Medicine, Bronx, NY 10461, USA
    Am J Physiol Renal Physiol 289:F186-93. 2005
    ..glucose and plasma glucose homeostasis, the tissue distribution and regulation of glucose transporter GLUT8, a new member of the glucose transporter family with important functions in cellular survival, were examined...
  68. ncbi GLUT8 subcellular localization and absence of translocation to the plasma membrane in PC12 cells and hippocampal neurons
    Mathieu Widmer
    Department of Physiology, University of Lausanne, 27 rue du Bugnon, 1005 Lausanne, Switzerland
    Endocrinology 146:4727-36. 2005
    b>GLUT8 is a high-affinity glucose transporter present mostly in testes and a subset of brain neurons...
  69. ncbi Identification and characterization of p49/STRAP as a novel GLUT4-binding protein
    Ivonne Lisinski
    EDMNS DB NIDDK NIH, Bethesda, MD, USA
    Biochem Biophys Res Commun 344:1179-85. 2006
    ..domain of p49 in adipose cells reduces protein synthesis and cell-surface expression of GLUT4, but not of GLUT8. Moreover, cell-surface expression of a p49-binding-deficient GLUT4 mutant (ED/QN) is also reduced...
  70. ncbi Endocytosis of the glucose transporter GLUT8 is mediated by interaction of a dileucine motif with the beta2-adaptin subunit of the AP-2 adaptor complex
    Ulrike Schmidt
    German Institute of Human Nutrition, Potsdam, Nuthetal, Germany
    J Cell Sci 119:2321-31. 2006
    The glucose transporter GLUT8 cycles between intracellular vesicles and the plasma membrane. Like the insulin-responsive glucose transporter GLUT4, GLUT8 is primarily located in intracellular compartments under basal conditions...
  71. ncbi Hexose transporter mRNAs for GLUT4, GLUT5, and GLUT12 predominate in human muscle
    Charles A Stuart
    Department of Internal Medicine, East Tennessee State University James H Quillen College of Medicine, Johnson City, Tennessee 37614 0622, USA
    Am J Physiol Endocrinol Metab 291:E1067-73. 2006
    ..amplified 78- to 241-base fragments, and cDNA standards were cloned for GLUT1, GLUT2, GLUT3, GLUT4, GLUT5, GLUT6, GLUT8, GLUT9, GLUT10, GLUT11, GLUT12, and GAPDH...
  72. ncbi Overexpression of GLUT5 in diabetic muscle is reversed by pioglitazone
    Charles A Stuart
    Department of Internal Medicine, East Tennessee State University, James H Quillen College of Medicine, Johnson City, Tennessee 37614 0622, USA
    Diabetes Care 30:925-31. 2007
    ..This study was undertaken to quantify the expression of muscle GLUT in type 2 diabetes and to determine if treatment with an insulin-enhancing thiazolidenedione drug, pioglitazone, would alter its expression...
  73. ncbi Expression and regulation of glucose transporters in the bovine mammary gland
    F Q Zhao
    Lactation and Mammary Gland Biology Group, Department of Animal Science, University of Vermont, Burlington 05405, USA
    J Dairy Sci 90:E76-86. 2007
    ..However, the bovine lactating mammary gland also expresses GLUT3, GLUT4, GLUT5, GLUT8, GLUT12, and sodium-dependent SGLT1 and SGLT2 at different levels...
  74. ncbi The expression of GLUT8, GLUT9a, and GLUT9b in the mouse testis and sperm
    Sung Tae Kim
    Department of Obstetrics and Gynecology, Washington University in St Louis, St Louis, Missouri 63110, USA
    Reprod Sci 14:445-55. 2007
    ..b>GLUT8, GLUT9a, and GLUT9b proteins are expressed in the most intraseminiferous tubula cells and Leydig cells...
  75. ncbi Decreased [18F]fluoro-2-deoxy-d-glucose incorporation and increased glucose transport are associated with resistance to 5FU in MCF7 cells in vitro
    Tim A D Smith
    PET Unit, Department of Biomedical Physics, University of Aberdeen, Foresterhill, Aberdeen AB25 2ZD, UK
    Nucl Med Biol 34:955-60. 2007
    ..Resistant cells selected by exposure to chemotherapy agents may exhibit differences in [18F]fluoro-2-deoxy-d-glucose (FDG) incorporation, as compared with sensitive cells...
  76. pmc A set of genes previously implicated in the hypoxia response might be an important modulator in the rat ear tissue response to mechanical stretch
    Vishal Saxena
    Surgery, Brigham and Women s Hospital, Boston, MA, USA
    BMC Genomics 8:430. 2007
    ..The absolute enrichment (AE) algorithm that obtains a combined up and down regulated picture of the expression analysis was implemented...
  77. pmc Targeted disruption of Slc2a8 (GLUT8) reduces motility and mitochondrial potential of spermatozoa
    Verena Gawlik
    Department of Pharmacology, German Institute of Human Nutrition Potsdam Rehbruecke, Germany
    Mol Membr Biol 25:224-35. 2008
    b>GLUT8 is a class 3 sugar transport facilitator which is predominantly expressed in testis and also detected in brain, heart, skeletal muscle, adipose tissue, adrenal gland, and liver...
  78. pmc Deletion of glucose transporter GLUT8 in mice increases locomotor activity
    S Schmidt
    Department of Pharmacology, German Institute of Human Nutrition Potsdam Rehbruecke, Arthur Scheunert Allee 114 116, Nuthetal, Germany
    Behav Genet 38:396-406. 2008
    ..In addition, GLUT8 is expressed in some regions of the brain...
  79. doi Paternal effect on embryo quality in diabetic mice is related to poor sperm quality and associated with decreased glucose transporter expression
    Sung Tae Kim
    Department of Obstetrics and Gynecology, Washington University in St Louis, 660 South Euclid Avenue, St Louis, Missouri 63110, USA
    Reproduction 136:313-22. 2008
    ..This is the first study to link a paternal metabolic abnormality to a sperm effect on cell division and subsequent embryonic development...
  80. pmc Similar [DE]XXXL[LI] motifs differentially target GLUT8 and GLUT12 in Chinese hamster ovary cells
    Lauren B Flessner
    Department of Obsetrics and Gynecology, Washington University School of Medicine, 660 South Euclid Ave, St Louis, MO 63110, USA
    Traffic 10:324-33. 2009
    ..We have previously shown that another class III GLUT8 contains a [DE]XXXL[LI] motif that directs it to late endosomal/lysosomal compartments...
  81. doi Expression and regulation of insulin and the glucose transporter GLUT8 in the testes of diabetic rats
    O Gomez
    Departamento de Medicina y Cirugia Animal, Universidad CEU Cardenal Herrera, Moncada 46113, Valencia, Spain
    Horm Metab Res 41:343-9. 2009
    ..The aim of this study was to analyze the levels and localization of the glucose transporter GLUT8 and insulin in the testes of rats induced to a diabetic status by a single dose of streptozotocin...
  82. pmc Regulation of facilitative glucose transporters and AKT/MAPK/PRKAA signaling via estradiol and progesterone in the mouse uterine epithelium
    Sung Tae Kim
    Department of Obstetrics and Gynecology, Washington University School of Medicine, St Louis, Missouri 63110, USA
    Biol Reprod 81:188-98. 2009
    ....
  83. pmc Neuronal glucose transporter isoform 3 deficient mice demonstrate features of autism spectrum disorders
    Y Zhao
    Division of Neonatology, Neonatal Research Center, David Geffen School of Medicine UCLA, Los Angeles, CA 90095, USA
    Mol Psychiatry 15:286-99. 2010
    ..occurred despite metabolic adaptations consisting of an increase in microvascular/glial GLUT1, neuronal GLUT8 and monocarboxylate transporter isoform 2 concentrations, with minimal to no change in brain glucose uptake but an ..
  84. pmc Lysosomal localization of GLUT8 in the testis--the EXXXLL motif of GLUT8 is sufficient for its intracellular sorting via AP1- and AP2-mediated interaction
    Muhammed Kasim Diril
    Institute of Chemistry and Biochemistry, Department of Membrane Biochemistry, Freie Universität and Charité Universitätsmedizin Berlin, Takustrasse 6, Berlin, Germany
    FEBS J 276:3729-43. 2009
    The class III sugar transport facilitator GLUT8 co-localizes with the lysosomal protein LAMP1 in heterologous expression systems...
  85. ncbi Expression of hexokinases and glucose transporters in treated and untreated oesophageal adenocarcinoma
    Philippe Fonteyne
    Department of Nuclear Medicine and Molecular Imaging, University Medical Center Groningen, University of Groningen, The Netherlands
    Histol Histopathol 24:971-7. 2009
    ..In patients that underwent primary surgery, Hscores of GLUT8 (micro 6.7; sd3.3) and GLUT1 (micro 5.5; sd: 5.3) were significantly higher than Hscores of GLUT9 (micro 2.2; sd 1...
  86. doi High glucose inhibits HCO3(-) and fluid secretion in rat pancreatic ducts
    Sachiko Futakuchi
    Department of Gastroenterology, Nagoya University Graduate School of Medicine, 65 Tsurumai Cho, Showa Ku, Nagoya 466 8550, Japan
    Pflugers Arch 459:215-26. 2009
    ..Sodium-dependent glucose cotransporter 1 (SGLT1), glucose transporter (GLUT)1, GLUT2, and GLUT8 transcripts were detected by reverse transcriptase polymerase chain reaction in isolated ducts...
  87. doi Expression of mRNA for glucose transport proteins in jejunum, liver, kidney and skeletal muscle of pigs
    J R Aschenbach
    Institute of Veterinary Physiology, University of Leipzig, An den Tierkliniken 7, D 04103 Leipzig, Germany
    J Physiol Biochem 65:251-66. 2009
    ..facilitated glucose transporter) in intestine revealed the presence of mRNA for GLUT1, GLUT2, GLUT5, GLUT7 and GLUT8, while GLUT3, GLUT4, GLUT10 and GLUT11 were also detectable...
  88. doi Developmental competence and mRNA expression of preimplantation in vitro-produced embryos from prepubertal and postpubertal cattle and their relationship with apoptosis after intraovarian administration of IGF-1
    J Zaraza
    Institute of Farm Animal Genetics, Friedrich Loeffler Institut FLI, Mariensee, Neustadt, Germany
    Theriogenology 74:75-89. 2010
    ..on (1) oocyte developmental competence, (2) the expression pattern of six developmentally important genes (GLUT3, GLUT8, AKT1, BCL-XL, BAD, and BAX), and (3) its relationship with apoptosis (female Holstein-Friesian)...
  89. ncbi Glucose transport in interlobular ducts isolated from rat pancreas
    Sachiko Futakuchi
    Department of Gastroenterology, Nagoya University Graduate School of Medicine, Nagoya, Japan
    J Med Invest 56:308-11. 2009
    ..express Na(+)-dependent glucose transporter, SGLT1 and Na(+)-independent glucose transporters, GLUT1, GLUT2, and GLUT8. We examined transepithelial glucose transport by pancreatic duct...
  90. pmc Acute modulation of sugar transport in brain capillary endothelial cell cultures during activation of the metabolic stress pathway
    Anthony J Cura
    Department of Biochemistry and Molecular Pharmacology, University of Massachusetts Medical School, Worcester, Massachusetts 01605, USA
    J Biol Chem 285:15430-9. 2010
    ..GLUT1, GLUT8, and GLUT9 mRNAs are detected in bEnd...
  91. doi LPS-induced inflammation downregulates mammary gland glucose, fatty acid, and L-carnitine transporter expression at different lactation stages
    Binbing Ling
    College of Pharmacy and Nutrition, University of Saskatchewan, 110 Science Place, Saskatoon, Saskatchewan, Canada S7N5C9
    Res Vet Sci 89:200-2. 2010
    ..p.) injection. Fold differences in the mRNA expression of glucose transporters Glut1, Glut8 and Sglt1, fatty acid transporters Fatp1, Fatp4 and Fabp3, and L-carnitine transporters Octn1, Octn2, and Octn3 ..
  92. doi Screening and identification of differentially expressed genes from chickens infected with Newcastle disease virus by suppression subtractive hybridization
    Daoliang Lan
    College of Life Science and Technology, Southwest University for Nationality, Chengdu, People s Republic of China
    Avian Pathol 39:151-9. 2010
    ..LAMC1, COL4A1), stress response (DNAJC15, CIRBP), immune response (TIA1, TOX, CMIP), metabolism (RPS15A, RPL32, GLUT8, CYPR21, DPYD, LOC417295), oxidation-reduction (TXN, MSRB3, GCLC), and others...
  93. doi The effect of monosaccharide sugars and pyruvate on the differentiation and metabolism of sheep granulosa cells in vitro
    B K Campbell
    Division of Human Development, School of Clinical Sciences, University of Nottingham, QMC, Nottingham, UK
    Reproduction 140:541-50. 2010
    ....
  94. pmc Developmental regulation of glucose transporters GLUT3, GLUT4 and GLUT8 in the mouse cerebellar cortex
    Olga Gomez
    Departamento de Medicina y Cirugia Animal, Universidad CEU Cardenal Herrera, Moncada, Valencia, Spain
    J Anat 217:616-23. 2010
    ..In this work we investigate how the expression of the main neuronal glucose transporters (GLUT3, GLUT4 and GLUT8) is modified during cerebellar cortex maturation...
  95. doi Genetic variability of the fatty acid synthase pathway is not associated with prostate cancer risk in the European Prospective Investigation on Cancer (EPIC)
    Daniele Campa
    German Cancer Research Center, DKFZ, Heidelberg, Germany
    Eur J Cancer 47:420-7. 2011
    ..None of the SNPs reached statistical significance after adjusting for multiple comparisons. Common SNPs in the fatty acid synthase pathway are not major contributors to prostate cancer risk...
  96. pmc The amino acids upstream of NH(2)-terminal dileucine motif play a role in regulating the intracellular sorting of the Class III transporters GLUT8 and GLUT12
    Lauren B Aerni-Flessner
    Departments of Obstetrics and Gynecology and Cell Biology and Physiology, Washington University School of Medicine, St Louis, MO 63110 USA
    Mol Membr Biol 28:30-41. 2011
    ..The class III glucose transporters GLUT8 and GLUT12 both contain a similar [DE]XXXL[LI] dileucine sorting signal in their amino terminus...
  97. pmc Adiponectin and adiponectin receptors in the mouse preimplantation embryo and uterus
    S T Kim
    Department of Obstetrics and Gynecology, Washington University in St Louis, St Louis, MO 63110, USA
    Hum Reprod 26:82-95. 2011
    ..Our objective was to define the expression and hormonal regulation of Adipoq and its receptors in the mouse preimplantation embryo and uterus...
  98. pmc Glucose transporters and ATP-gated K+ (KATP) metabolic sensors are present in type 1 taste receptor 3 (T1r3)-expressing taste cells
    Karen K Yee
    Monell Chemical Senses Center, Philadelphia, PA 19104 3308, USA
    Proc Natl Acad Sci U S A 108:5431-6. 2011
    ..quantitative PCR, in situ hybridization, and immunohistochemistry, we determined that several GLUTs (GLUT2, GLUT4, GLUT8, and GLUT9), a sodium-glucose cotransporter (SGLT1), and two components of the ATP-gated K(+) (K(ATP)) metabolic ..
  99. doi Regulation of leptin synthesis during adipogenesis in males of a vespertilionid bat, Scotophilus heathi
    Vikas Kumar Roy
    Department of Zoology, Banaras Hindu University, Varanasi 221005, India
    J Exp Biol 214:1599-606. 2011
    ..Two glucose transporters (GLUT4 and GLUT8) are utilized for transport of glucose in the WAT during adipogenesis in the bat...
  100. pmc Glucose transporters GLUT4 and GLUT8 are upregulated after facial nerve axotomy in adult mice
    Olga Gomez
    Departamento de Medicina y Cirugia Animal, Universidad CEU Cardenal Herrera, Moncada Valencia, Spain
    J Anat 219:525-30. 2011
    ..This work analyses the expression of the neuronal glucose transporters GLUT3, GLUT4 and GLUT8 in the facial nucleus of adult mice during the first days after facial nerve axotomy...

Research Grants10

  1. THE EFFECT OF DIOXINS ON GLUCOSE HOMEOSTASIS IN MURINE TESTES
    KENAN RIFAT OMURTAG; Fiscal Year: 2013
    ..Are protein and mRNA expression of GLUT8, GLUT9a and GLUT9b in the testes affected by exposure to TCDD? Is the location of the transporters altered? ..
  2. GLUTS AND GLUCOSE TRANSPORT IN THE MOUSE BLASTOCYST
    Kelle H Moley; Fiscal Year: 2012
    ..Specific Aim 3 investigates the possible role GLUT8 may play in autophagy in the mouse blastocyst...
  3. GLUT8 Overexpression in Cardioprotection
    Maureen J Charron; Fiscal Year: 2010
    ..G4 Null mice show an increased expression of GLUT8, a new member of the glucose transporter family...
  4. Glucose Meatbolism in the Human Ovary
    MAUREEN CHARRON; Fiscal Year: 2004
    ..While not sensitive to regulation by sex steroids, GLUT4 is commonly decreased in insulin resistant states. GLUTx1, also known as GLUT8, is a recently discovered glucose transporter that appears to be sex steroid regulated...
  5. IGF INDUCED TOXICITY IN PREIMPLANTATION EMBRYOS
    Kelle Moley; Fiscal Year: 2007
    ..IGF-1 receptor resulting in decreased glucose uptake via translocation of the facilitative glucose transporter, GLUT8. This decrease results in apoptosis, and miscarriage when these blastocysts are transferred back into foster mice...
  6. Regulation of Cardiac Glucose Transporters
    MAUREEN CHARRON; Fiscal Year: 2007
    ..GLUT1 and GLUT8 are also expressed in the heart...
  7. Development of Diabetic Cardiomyopathy in GLUT4 +/- Mice
    MAUREEN CHARRON; Fiscal Year: 2004
    ..Each aim will identify alterations in insulin action through Akt/PKB, GLUT4- and GLUTx1 translocation, substrate partitioning/trafficking, and GLUT and UCP2/3 gene/protein expression in hearts of GLUT4+/..
  8. Molecular Aspects of Implantation
    Kelle Moley; Fiscal Year: 2006
    ..abstract_text> ..
  9. Maternal Diabetes and Oocyte Quality
    Kelle Moley; Fiscal Year: 2007
    ..Treatment that is more aggressive may be indicated for these patients throughout their reproductive years may be indicated. ..
  10. REGULATION OF MESANGIAL CELL ECM SYNTHESIS BY GLUT1
    Charles Heilig; Fiscal Year: 2002
    ..Deletion mutation analysis of activated reporter constructs will locate the limiting sequences of these cis-acting elements. ..