GLUT8

Summary

Gene Symbol: GLUT8
Description: solute carrier family 2 member 8
Alias: GLUT8, GLUTX1, solute carrier family 2, facilitated glucose transporter member 8, glucose transporter type 8, glucose transporter type X1, solute carrier family 2 (facilitated glucose transporter), member 8
Species: human
Products:     GLUT8

Top Publications

  1. Xia W, Osorio J, Yang Y, Liu D, Jiang M. Short communication: Characterization of gene expression profiles related to yak milk protein synthesis during the lactation cycle. J Dairy Sci. 2018;: pubmed publisher
    ..In conclusion, a critical role for AA and glucose transporters and insulin signaling through mTOR for regulation of yak milk protein synthesis was revealed in this study of the yak mammary gland. ..
  2. Mayer A, Higgins C, Heitmeier M, Kraft T, Qian X, Crowley J, et al. SLC2A8 (GLUT8) is a mammalian trehalose transporter required for trehalose-induced autophagy. Sci Rep. 2016;6:38586 pubmed publisher
    ..fluorescence microscopic and radiolabeled uptake evidence that trehalose traverses the plasma membrane via SLC2A8 (GLUT8), a homolog of the trehalose transporter-1 (Tret1)...
  3. McMillan E, Ryu M, Diep C, Mendiratta S, Clemenceau J, Vaden R, et al. Chemistry-First Approach for Nomination of Personalized Treatment in Lung Cancer. Cell. 2018;173:864-878.e29 pubmed publisher
    ..Chemically addressable addictions to ciliogenesis in TTC21B mutants and GLUT8-dependent serine biosynthesis in KRAS/KEAP1 double mutants are prominent examples...
  4. Sarkar D, Singh S. Maternal exposure to polybrominated diphenyl ether (BDE-209) during lactation affects germ cell survival with altered testicular glucose homeostasis and oxidative status through down-regulation of Cx43 and p27Kip1 in prepubertal mice offspring. Toxicology. 2017;386:103-119 pubmed publisher
    ..glucose and lactate concentrations were markedly reduced in these pups with down-regulation in GLUT3 and GLUT8 expressions and decreased LDH activity...
  5. Sarkar D, Singh S. Neonatal hypothyroidism affects testicular glucose homeostasis through increased oxidative stress in prepubertal mice: effects on GLUT3, GLUT8 and Cx43. Andrology. 2017;5:749-762 pubmed publisher
    ..by Leydig cells is essential for testosterone biosynthesis and thus is largely dependent on glucose transporter 8 (GLUT8)...
  6. Vaughan O, Davies K, Ward J, De Blasio M, Fowden A. A physiological increase in maternal cortisol alters uteroplacental metabolism in the pregnant ewe. J Physiol. 2016;594:6407-6418 pubmed publisher
    ..However, when maternal cortisol concentrations are raised chronically, prolonged elevation of uteroplacental lactate production may compromise fetal wellbeing. ..
  7. Maria Z, Campolo A, Scherlag B, Ritchey J, Lacombe V. Dysregulation of insulin-sensitive glucose transporters during insulin resistance-induced atrial fibrillation. Biochim Biophys Acta Mol Basis Dis. 2018;1864:987-996 pubmed publisher
    ..Although GLUT4 is the major isoform, GLUT8 has emerged as a novel insulin-sensitive cardiac isoform...
  8. McMillin S, Schmidt D, Kahn B, Witczak C. GLUT4 Is Not Necessary for Overload-Induced Glucose Uptake or Hypertrophic Growth in Mouse Skeletal Muscle. Diabetes. 2017;66:1491-1500 pubmed publisher
    ..uptake was not inhibited by d-fructose, demonstrating that the fructose-transporting GLUT2, GLUT5, GLUT8, and GLUT12 do not mediate this effect. To assess additional GLUTs, immunoblots were performed...
  9. Ijiri D, Shimamoto S, Kawaguchi M, Furukawa A, Nakashima K, Tada O, et al. Effects of first exogenous nutrients on the mRNA levels of atrogin-1/MAFbx and GLUT1 in the skeletal muscles of newly hatched chicks. Comp Biochem Physiol A Mol Integr Physiol. 2017;205:8-14 pubmed publisher
    ..In addition, the mRNA levels of GLUT1 and GLUT8 were increased in the sartorius muscle after the intubation...

More Information

Publications39

  1. Anjum S, Krishna A, Tsutsui K. Possible Role of GnIH as a Mediator between Adiposity and Impaired Testicular Function. Front Endocrinol (Lausanne). 2016;7:6 pubmed publisher
    ..with GnIH both in vivo and in vitro showed decreased uptake of glucose by downregulation of glucose transporter 8 (GLUT8) expressions in the testis, which in turn resulted in the decreased synthesis of testosterone...
  2. Jackson E, Rendina Ruedy E, Smith B, Lacombe V. Loss of Toll-Like Receptor 4 Function Partially Protects against Peripheral and Cardiac Glucose Metabolic Derangements During a Long-Term High-Fat Diet. PLoS ONE. 2015;10:e0142077 pubmed publisher
    ..TLR4-mutant mice fed a HFD also had increased expression of GLUT8, a novel isoform, compared to mice fed a normal diet...
  3. de Laat M, Robinson M, Gruntmeir K, Liu Y, Soma L, Lacombe V. AICAR administration affects glucose metabolism by upregulating the novel glucose transporter, GLUT8, in equine skeletal muscle. Vet J. 2015;205:381-6 pubmed publisher
    ..05) in skeletal muscle. While GLUT4 and GLUT1 protein expression remained unchanged, GLUT8 was increased (P <0.05) following AICAR treatment...
  4. Maria Z, Campolo A, Lacombe V. Diabetes Alters the Expression and Translocation of the Insulin-Sensitive Glucose Transporters 4 and 8 in the Atria. PLoS ONE. 2015;10:e0146033 pubmed publisher
    ..Although GLUT4 is the major isoform in the heart, GLUT8 has recently emerged as a novel cardiac isoform...
  5. DeBosch B, Chi M, Moley K. Glucose transporter 8 (GLUT8) regulates enterocyte fructose transport and global mammalian fructose utilization. Endocrinology. 2012;153:4181-91 pubmed publisher
    ..The in vivo function of GLUT8, however, remains unclear...
  6. Verma R, Krishna A. Effect of Letrozole, a selective aromatase inhibitor, on testicular activities in adult mice: Both in vivo and in vitro study. Gen Comp Endocrinol. 2017;241:57-68 pubmed publisher
    ..The decreased effects of insulin inhibited the glucose transport in the testis by suppressing GLUT8. The decreased level of testicular glucose may produce less lactate as energy support to developing germ cells ..
  7. Shimamoto S, Ijiri D, Kawaguchi M, Nakashima K, Ohtsuka A. Gene expression pattern of glucose transporters in the skeletal muscles of newly hatched chicks. Biosci Biotechnol Biochem. 2016;80:1382-5 pubmed publisher
    The gene expression pattern of the glucose transporters (GLUT1, GLUT3, GLUT8, and GLUT12) among pectoralis major and minor, biceps femoris, and sartorius muscles from newly hatched chicks was examined...
  8. Steinhauser C, Landers M, Myatt L, Burghardt R, Vallet J, Bazer F, et al. Fructose Synthesis and Transport at the Uterine-Placental Interface of Pigs: Cell-Specific Localization of SLC2A5, SLC2A8, and Components of the Polyol Pathway. Biol Reprod. 2016;95:108 pubmed
  9. Chong M, Goh L, Lim W, Chan M, Tay L, Chen G, et al. Gene expression profiling of peripheral blood leukocytes shows consistent longitudinal downregulation of TOMM40 and upregulation of KIR2DL5A, PLOD1, and SLC2A8 among fast progressors in early Alzheimer's disease. J Alzheimers Dis. 2013;34:399-405 pubmed publisher
  10. Schurmann A, Axer H, Scheepers A, Doege H, Joost H. The glucose transport facilitator GLUT8 is predominantly associated with the acrosomal region of mature spermatozoa. Cell Tissue Res. 2002;307:237-42 pubmed
    The glucose transporter 8 (GLUT8) is a recently identified member of the family of sugar transport facilitators. In human tissues GLUT8 is predominantly expressed in testis in a gonadotropin-dependent manner...
  11. Proszkowiec Weglarz M, Dupont J, Rideau N, Gespach C, Simon J, Porter T. Insulin immuno-neutralization decreases food intake in chickens without altering hypothalamic transcripts involved in food intake and metabolism. Poult Sci. 2017;: pubmed publisher
    ..In addition, 5 h fasting increased levels of NPY, TAS1R1, DIO2, LEPR, GLUT1, GLUT3, GLUT8, and GCK mRNA. In contrast, AI had no impact on the levels of any selected mRNA...
  12. Warzych E, Pawlak P, Pszczola M, Cieslak A, Madeja Z, Lechniak D. Interactions of bovine oocytes with follicular elements with respect to lipid metabolism. Anim Sci J. 2017;88:1491-1497 pubmed publisher
    ..mRNA expression of seven genes in cumulus and granulosa cells (SCD, FADS2, ELOVL2, ELOVL5, GLUT1, GLUT3, GLUT8; real time polymerase chain reaction) and fatty acid (FA) composition in FF (gas chromatography)...
  13. McBrayer S, Cheng J, Singhal S, Krett N, Rosen S, Shanmugam M. Multiple myeloma exhibits novel dependence on GLUT4, GLUT8, and GLUT11: implications for glucose transporter-directed therapy. Blood. 2012;119:4686-97 pubmed publisher
    ..We also establish that the activities of the enigmatic transporters GLUT8 and GLUT11 are required for proliferation and viability in myeloma, albeit because of functionalities probably ..
  14. Szablewski L. Glucose transporters in healthy heart and in cardiac disease. Int J Cardiol. 2017;230:70-75 pubmed publisher
    ..These transport proteins are GLUT1, GLUT3, GLUT8, GLUT10, GLUT11, GLUT12 and SGLT1...
  15. Yang J, Hamid S, Cai J, Liu Q, Xu S, Zhang Z. Selenium deficiency-induced thioredoxin suppression and thioredoxin knock down disbalanced insulin responsiveness in chicken cardiomyocytes through PI3K/Akt pathway inhibition. Cell Signal. 2017;38:192-200 pubmed publisher
    ..IGFBP4), insulin receptor (IR), insulin receptor substrates (IRS1, IRS2), and glucose transporters (GLUT1, GLUT3, GLUT8), however, IGFBP3 expression increased in Txn knock down cardiomyocytes...
  16. DeBosch B, Chen Z, Saben J, Finck B, Moley K. Glucose transporter 8 (GLUT8) mediates fructose-induced de novo lipogenesis and macrosteatosis. J Biol Chem. 2014;289:10989-98 pubmed publisher
    ..b>GLUT8 (Slc2A8) is a facilitative glucose and fructose transporter that is highly expressed in liver, heart, and other ..
  17. Mashima M, Chiba Y, Murakami R, Uemura N, Matsumoto K, Kawauchi M, et al. Glucose transporter 8 immunoreactivity in astrocytic and microglial cells in subependymal areas of human brains. Neurosci Lett. 2017;636:90-94 pubmed publisher
    Glucose transporter 8 (GLUT8), a glucose/fructose transporter, has been shown to be expressed in neuronal cells in several brain areas...
  18. Ibberson M, Uldry M, Thorens B. GLUTX1, a novel mammalian glucose transporter expressed in the central nervous system and insulin-sensitive tissues. J Biol Chem. 2000;275:4607-12 pubmed
    Based on homology with GLUT1-5, we have isolated a cDNA for a novel glucose transporter, GLUTX1. This cDNA encodes a protein of 478 amino acids that shows between 29 and 32% identity with rat GLUT1-5 and 32-36% identity with plant and ..
  19. Fonteyne P, Casneuf V, Pauwels P, Van Damme N, Peeters M, Dierckx R, et al. Expression of hexokinases and glucose transporters in treated and untreated oesophageal adenocarcinoma. Histol Histopathol. 2009;24:971-7 pubmed publisher
    ..In patients that underwent primary surgery, Hscores of GLUT8 (micro 6.7; sd3.3) and GLUT1 (micro 5.5; sd: 5.3) were significantly higher than Hscores of GLUT9 (micro 2.2; sd 1...
  20. Wei C, Bajpai R, Sharma H, Heitmeier M, Jain A, Matulis S, et al. Development of GLUT4-selective antagonists for multiple myeloma therapy. Eur J Med Chem. 2017;139:573-586 pubmed publisher
    ..In sum, we report development of selective GLUT4 inhibitors lacking inhibitory activity against GLUT1 and GLUT8. We show that selective pharmacological inhibition of GLUT4 is feasible and this may represent a novel strategy ..
  21. Warzych E, Pawlak P, Pszczola M, Cieslak A, Lechniak D. Prepubertal heifers versus cows-The differences in the follicular environment. Theriogenology. 2017;87:36-47 pubmed publisher
    ..in energy metabolism (fatty acids [FAs] metabolism-ELOVL2, ELOVL5, SCD, FADS2, glucose transport-GLUT1, GLUT3, GLUT8) in CC and GC as well as FA composition and glucose concentration in FF...
  22. Bai S, Pan S, Zhang K, Ding X, Wang J, Zeng Q, et al. Long-term effect of dietary overload lithium on the glucose metabolism in broiler chickens. Environ Toxicol Pharmacol. 2017;54:191-198 pubmed publisher
    ..05) mRNA expression of glucose transporter (GLUT) 3 and GLUT9 in liver, and GLUT1, GLUT3, GLUT8, and GLUT9 in pectoralis major, but decreased (p<0...
  23. Xing M, Chen X, Li X, Yang Y, Wang X, Cao X, et al. Histone deacetylase inhibitor stimulates E2 and P4 secretion in sika deer ovarian granulosa cells at a moderate dose. Cell Biol Int. 2017;: pubmed publisher
    ..and induced GCs apoptosis by upregulating expression of BAX, meanwhile, downregulating expression of GLUT3, GLUT8, BCL-XL...
  24. Campa D, Husing A, Chang Claude J, Dostal L, Boeing H, Kröger J, et al. Genetic variability of the fatty acid synthase pathway is not associated with prostate cancer risk in the European Prospective Investigation on Cancer (EPIC). Eur J Cancer. 2011;47:420-7 pubmed publisher
    ..None of the SNPs reached statistical significance after adjusting for multiple comparisons. Common SNPs in the fatty acid synthase pathway are not major contributors to prostate cancer risk. ..
  25. Schmidt U, Briese S, Leicht K, Schurmann A, Joost H, Al Hasani H. Endocytosis of the glucose transporter GLUT8 is mediated by interaction of a dileucine motif with the beta2-adaptin subunit of the AP-2 adaptor complex. J Cell Sci. 2006;119:2321-31 pubmed
    The glucose transporter GLUT8 cycles between intracellular vesicles and the plasma membrane. Like the insulin-responsive glucose transporter GLUT4, GLUT8 is primarily located in intracellular compartments under basal conditions...
  26. Xi H, Zhang Z, Ji R, Shen H, Fan X, Li Q, et al. Expression of glucose transporter 8 (GLUT8) in spermatogenesis of adult boar testes. Acta Histochem. 2017;119:632-637 pubmed publisher
    The present study was designed to investigate the glucose transporter 8 (GLUT8) expression and localization in adult boar testis...
  27. Richardson S, Neama G, Phillips T, Bell S, Carter S, Moley K, et al. Molecular characterization and partial cDNA cloning of facilitative glucose transporters expressed in human articular chondrocytes; stimulation of 2-deoxyglucose uptake by IGF-I and elevated MMP-2 secretion by glucose deprivation. Osteoarthritis Cartilage. 2003;11:92-101 pubmed
    ..Furthermore, secretion of MMP-2 was increased in alginate cultures deprived of glucose. The data supports a critical role for glucose transport and metabolism in the synthesis and degradation of cartilage. ..
  28. Doege H, Schurmann A, Bahrenberg G, Brauers A, Joost H. GLUT8, a novel member of the sugar transport facilitator family with glucose transport activity. J Biol Chem. 2000;275:16275-80 pubmed
    b>GLUT8 is a novel glucose transporter-like protein that exhibits significant sequence similarity with the members of the sugar transport facilitator family (29.4% of amino acids identical with GLUT1). Human and mouse sequence (86...
  29. Schmidt S, Joost H, Schurmann A. GLUT8, the enigmatic intracellular hexose transporter. Am J Physiol Endocrinol Metab. 2009;296:E614-8 pubmed publisher
    b>GLUT8 is a class III sugar transporter predominantly expressed in testis and brain...
  30. Murakami R, Chiba Y, Tsuboi K, Matsumoto K, Kawauchi M, Fujihara R, et al. Immunoreactivity of glucose transporter 8 is localized in the epithelial cells of the choroid plexus and in ependymal cells. Histochem Cell Biol. 2016;146:231-6 pubmed publisher
    ..In this study, immunoreactivity for the fructose transporter GLUT8 was observed in the cytoplasm of the epithelial cells in the choroid plexus and in the ependymal cells of the ..