GLUT8

Summary

Gene Symbol: GLUT8
Description: solute carrier family 2 member 8
Alias: GLUT8, GLUTX1, solute carrier family 2, facilitated glucose transporter member 8, glucose transporter type 8, glucose transporter type X1, solute carrier family 2 (facilitated glucose transporter), member 8
Species: human
Products:     GLUT8

Top Publications

  1. Warzych E, Pawlak P, Pszczola M, Cieslak A, Madeja Z, Lechniak D. Interactions of bovine oocytes with follicular elements with respect to lipid metabolism. Anim Sci J. 2017;88:1491-1497 pubmed publisher
    ..mRNA expression of seven genes in cumulus and granulosa cells (SCD, FADS2, ELOVL2, ELOVL5, GLUT1, GLUT3, GLUT8; real time polymerase chain reaction) and fatty acid (FA) composition in FF (gas chromatography)...
  2. Schurmann A, Axer H, Scheepers A, Doege H, Joost H. The glucose transport facilitator GLUT8 is predominantly associated with the acrosomal region of mature spermatozoa. Cell Tissue Res. 2002;307:237-42 pubmed
    The glucose transporter 8 (GLUT8) is a recently identified member of the family of sugar transport facilitators. In human tissues GLUT8 is predominantly expressed in testis in a gonadotropin-dependent manner...
  3. Proszkowiec Weglarz M, Dupont J, Rideau N, Gespach C, Simon J, Porter T. Insulin immuno-neutralization decreases food intake in chickens without altering hypothalamic transcripts involved in food intake and metabolism. Poult Sci. 2017;: pubmed publisher
    ..In addition, 5 h fasting increased levels of NPY, TAS1R1, DIO2, LEPR, GLUT1, GLUT3, GLUT8, and GCK mRNA. In contrast, AI had no impact on the levels of any selected mRNA...
  4. Chong M, Goh L, Lim W, Chan M, Tay L, Chen G, et al. Gene expression profiling of peripheral blood leukocytes shows consistent longitudinal downregulation of TOMM40 and upregulation of KIR2DL5A, PLOD1, and SLC2A8 among fast progressors in early Alzheimer's disease. J Alzheimers Dis. 2013;34:399-405 pubmed publisher
    ....
  5. McBrayer S, Cheng J, Singhal S, Krett N, Rosen S, Shanmugam M. Multiple myeloma exhibits novel dependence on GLUT4, GLUT8, and GLUT11: implications for glucose transporter-directed therapy. Blood. 2012;119:4686-97 pubmed publisher
    ..We also establish that the activities of the enigmatic transporters GLUT8 and GLUT11 are required for proliferation and viability in myeloma, albeit because of functionalities probably ..
  6. Yang J, Hamid S, Cai J, Liu Q, Xu S, Zhang Z. Selenium deficiency-induced thioredoxin suppression and thioredoxin knock down disbalanced insulin responsiveness in chicken cardiomyocytes through PI3K/Akt pathway inhibition. Cell Signal. 2017;38:192-200 pubmed publisher
    ..IGFBP4), insulin receptor (IR), insulin receptor substrates (IRS1, IRS2), and glucose transporters (GLUT1, GLUT3, GLUT8), however, IGFBP3 expression increased in Txn knock down cardiomyocytes...
  7. Szablewski L. Glucose transporters in healthy heart and in cardiac disease. Int J Cardiol. 2017;230:70-75 pubmed publisher
    ..These transport proteins are GLUT1, GLUT3, GLUT8, GLUT10, GLUT11, GLUT12 and SGLT1...
  8. DeBosch B, Chen Z, Saben J, Finck B, Moley K. Glucose transporter 8 (GLUT8) mediates fructose-induced de novo lipogenesis and macrosteatosis. J Biol Chem. 2014;289:10989-98 pubmed publisher
    ..b>GLUT8 (Slc2A8) is a facilitative glucose and fructose transporter that is highly expressed in liver, heart, and other ..
  9. Ibberson M, Uldry M, Thorens B. GLUTX1, a novel mammalian glucose transporter expressed in the central nervous system and insulin-sensitive tissues. J Biol Chem. 2000;275:4607-12 pubmed
    Based on homology with GLUT1-5, we have isolated a cDNA for a novel glucose transporter, GLUTX1. This cDNA encodes a protein of 478 amino acids that shows between 29 and 32% identity with rat GLUT1-5 and 32-36% identity with plant and ..
  10. Fonteyne P, Casneuf V, Pauwels P, Van Damme N, Peeters M, Dierckx R, et al. Expression of hexokinases and glucose transporters in treated and untreated oesophageal adenocarcinoma. Histol Histopathol. 2009;24:971-7 pubmed publisher
    ..In patients that underwent primary surgery, Hscores of GLUT8 (micro 6.7; sd3.3) and GLUT1 (micro 5.5; sd: 5.3) were significantly higher than Hscores of GLUT9 (micro 2.2; sd 1...

Detail Information

Publications22

  1. Warzych E, Pawlak P, Pszczola M, Cieslak A, Madeja Z, Lechniak D. Interactions of bovine oocytes with follicular elements with respect to lipid metabolism. Anim Sci J. 2017;88:1491-1497 pubmed publisher
    ..mRNA expression of seven genes in cumulus and granulosa cells (SCD, FADS2, ELOVL2, ELOVL5, GLUT1, GLUT3, GLUT8; real time polymerase chain reaction) and fatty acid (FA) composition in FF (gas chromatography)...
  2. Schurmann A, Axer H, Scheepers A, Doege H, Joost H. The glucose transport facilitator GLUT8 is predominantly associated with the acrosomal region of mature spermatozoa. Cell Tissue Res. 2002;307:237-42 pubmed
    The glucose transporter 8 (GLUT8) is a recently identified member of the family of sugar transport facilitators. In human tissues GLUT8 is predominantly expressed in testis in a gonadotropin-dependent manner...
  3. Proszkowiec Weglarz M, Dupont J, Rideau N, Gespach C, Simon J, Porter T. Insulin immuno-neutralization decreases food intake in chickens without altering hypothalamic transcripts involved in food intake and metabolism. Poult Sci. 2017;: pubmed publisher
    ..In addition, 5 h fasting increased levels of NPY, TAS1R1, DIO2, LEPR, GLUT1, GLUT3, GLUT8, and GCK mRNA. In contrast, AI had no impact on the levels of any selected mRNA...
  4. Chong M, Goh L, Lim W, Chan M, Tay L, Chen G, et al. Gene expression profiling of peripheral blood leukocytes shows consistent longitudinal downregulation of TOMM40 and upregulation of KIR2DL5A, PLOD1, and SLC2A8 among fast progressors in early Alzheimer's disease. J Alzheimers Dis. 2013;34:399-405 pubmed publisher
    ....
  5. McBrayer S, Cheng J, Singhal S, Krett N, Rosen S, Shanmugam M. Multiple myeloma exhibits novel dependence on GLUT4, GLUT8, and GLUT11: implications for glucose transporter-directed therapy. Blood. 2012;119:4686-97 pubmed publisher
    ..We also establish that the activities of the enigmatic transporters GLUT8 and GLUT11 are required for proliferation and viability in myeloma, albeit because of functionalities probably ..
  6. Yang J, Hamid S, Cai J, Liu Q, Xu S, Zhang Z. Selenium deficiency-induced thioredoxin suppression and thioredoxin knock down disbalanced insulin responsiveness in chicken cardiomyocytes through PI3K/Akt pathway inhibition. Cell Signal. 2017;38:192-200 pubmed publisher
    ..IGFBP4), insulin receptor (IR), insulin receptor substrates (IRS1, IRS2), and glucose transporters (GLUT1, GLUT3, GLUT8), however, IGFBP3 expression increased in Txn knock down cardiomyocytes...
  7. Szablewski L. Glucose transporters in healthy heart and in cardiac disease. Int J Cardiol. 2017;230:70-75 pubmed publisher
    ..These transport proteins are GLUT1, GLUT3, GLUT8, GLUT10, GLUT11, GLUT12 and SGLT1...
  8. DeBosch B, Chen Z, Saben J, Finck B, Moley K. Glucose transporter 8 (GLUT8) mediates fructose-induced de novo lipogenesis and macrosteatosis. J Biol Chem. 2014;289:10989-98 pubmed publisher
    ..b>GLUT8 (Slc2A8) is a facilitative glucose and fructose transporter that is highly expressed in liver, heart, and other ..
  9. Ibberson M, Uldry M, Thorens B. GLUTX1, a novel mammalian glucose transporter expressed in the central nervous system and insulin-sensitive tissues. J Biol Chem. 2000;275:4607-12 pubmed
    Based on homology with GLUT1-5, we have isolated a cDNA for a novel glucose transporter, GLUTX1. This cDNA encodes a protein of 478 amino acids that shows between 29 and 32% identity with rat GLUT1-5 and 32-36% identity with plant and ..
  10. Fonteyne P, Casneuf V, Pauwels P, Van Damme N, Peeters M, Dierckx R, et al. Expression of hexokinases and glucose transporters in treated and untreated oesophageal adenocarcinoma. Histol Histopathol. 2009;24:971-7 pubmed publisher
    ..In patients that underwent primary surgery, Hscores of GLUT8 (micro 6.7; sd3.3) and GLUT1 (micro 5.5; sd: 5.3) were significantly higher than Hscores of GLUT9 (micro 2.2; sd 1...
  11. Wei C, Bajpai R, Sharma H, Heitmeier M, Jain A, Matulis S, et al. Development of GLUT4-selective antagonists for multiple myeloma therapy. Eur J Med Chem. 2017;139:573-586 pubmed publisher
    ..In sum, we report development of selective GLUT4 inhibitors lacking inhibitory activity against GLUT1 and GLUT8. We show that selective pharmacological inhibition of GLUT4 is feasible and this may represent a novel strategy ..
  12. Bai S, Pan S, Zhang K, Ding X, Wang J, Zeng Q, et al. Long-term effect of dietary overload lithium on the glucose metabolism in broiler chickens. Environ Toxicol Pharmacol. 2017;54:191-198 pubmed publisher
    ..05) mRNA expression of glucose transporter (GLUT) 3 and GLUT9 in liver, and GLUT1, GLUT3, GLUT8, and GLUT9 in pectoralis major, but decreased (p<0...
  13. Warzych E, Pawlak P, Pszczola M, Cieslak A, Lechniak D. Prepubertal heifers versus cows-The differences in the follicular environment. Theriogenology. 2017;87:36-47 pubmed publisher
    ..in energy metabolism (fatty acids [FAs] metabolism-ELOVL2, ELOVL5, SCD, FADS2, glucose transport-GLUT1, GLUT3, GLUT8) in CC and GC as well as FA composition and glucose concentration in FF...
  14. Xing M, Chen X, Li X, Yang Y, Wang X, Cao X, et al. Histone deacetylase inhibitor stimulates E2 and P4 secretion in sika deer ovarian granulosa cells at a moderate dose. Cell Biol Int. 2017;: pubmed publisher
    ..and induced GCs apoptosis by upregulating expression of BAX, meanwhile, downregulating expression of GLUT3, GLUT8, BCL-XL...
  15. Xi H, Zhang Z, Ji R, Shen H, Fan X, Li Q, et al. Expression of glucose transporter 8 (GLUT8) in spermatogenesis of adult boar testes. Acta Histochem. 2017;119:632-637 pubmed publisher
    The present study was designed to investigate the glucose transporter 8 (GLUT8) expression and localization in adult boar testis...
  16. Doege H, Schurmann A, Bahrenberg G, Brauers A, Joost H. GLUT8, a novel member of the sugar transport facilitator family with glucose transport activity. J Biol Chem. 2000;275:16275-80 pubmed
    b>GLUT8 is a novel glucose transporter-like protein that exhibits significant sequence similarity with the members of the sugar transport facilitator family (29.4% of amino acids identical with GLUT1). Human and mouse sequence (86...
  17. Campa D, Husing A, Chang Claude J, Dostal L, Boeing H, Kröger J, et al. Genetic variability of the fatty acid synthase pathway is not associated with prostate cancer risk in the European Prospective Investigation on Cancer (EPIC). Eur J Cancer. 2011;47:420-7 pubmed publisher
    ..None of the SNPs reached statistical significance after adjusting for multiple comparisons. Common SNPs in the fatty acid synthase pathway are not major contributors to prostate cancer risk. ..
  18. Schmidt U, Briese S, Leicht K, Schurmann A, Joost H, Al Hasani H. Endocytosis of the glucose transporter GLUT8 is mediated by interaction of a dileucine motif with the beta2-adaptin subunit of the AP-2 adaptor complex. J Cell Sci. 2006;119:2321-31 pubmed
    The glucose transporter GLUT8 cycles between intracellular vesicles and the plasma membrane. Like the insulin-responsive glucose transporter GLUT4, GLUT8 is primarily located in intracellular compartments under basal conditions...
  19. Richardson S, Neama G, Phillips T, Bell S, Carter S, Moley K, et al. Molecular characterization and partial cDNA cloning of facilitative glucose transporters expressed in human articular chondrocytes; stimulation of 2-deoxyglucose uptake by IGF-I and elevated MMP-2 secretion by glucose deprivation. Osteoarthritis Cartilage. 2003;11:92-101 pubmed
    ..Furthermore, secretion of MMP-2 was increased in alginate cultures deprived of glucose. The data supports a critical role for glucose transport and metabolism in the synthesis and degradation of cartilage. ..
  20. Schmidt S, Joost H, Schurmann A. GLUT8, the enigmatic intracellular hexose transporter. Am J Physiol Endocrinol Metab. 2009;296:E614-8 pubmed publisher
    b>GLUT8 is a class III sugar transporter predominantly expressed in testis and brain...