FTO

Summary

Gene Symbol: FTO
Description: FTO, alpha-ketoglutarate dependent dioxygenase
Alias: ALKBH9, BMIQ14, GDFD, alpha-ketoglutarate-dependent dioxygenase FTO, AlkB homolog 9, fat mass and obesity associated, fat mass and obesity-associated protein
Species: human
Products:     FTO

Top Publications

  1. Renström F, Payne F, Nordström A, Brito E, Rolandsson O, Hallmans G, et al. Replication and extension of genome-wide association study results for obesity in 4923 adults from northern Sweden. Hum Mol Genet. 2009;18:1489-96 pubmed publisher
    Recent genome-wide association studies (GWAS) have identified multiple risk loci for common obesity (FTO, MC4R, TMEM18, GNPDA2, SH2B1, KCTD15, MTCH2, NEGR1 and PCSK1)...
  2. Willer C, Speliotes E, Loos R, Li S, Lindgren C, Heid I, et al. Six new loci associated with body mass index highlight a neuronal influence on body weight regulation. Nat Genet. 2009;41:25-34 pubmed publisher
    Common variants at only two loci, FTO and MC4R, have been reproducibly associated with body mass index (BMI) in humans...
  3. Boissel S, Reish O, Proulx K, Kawagoe Takaki H, Sedgwick B, Yeo G, et al. Loss-of-function mutation in the dioxygenase-encoding FTO gene causes severe growth retardation and multiple malformations. Am J Hum Genet. 2009;85:106-11 pubmed publisher
    b>FTO is a nuclear protein belonging to the AlkB-related non-haem iron- and 2-oxoglutarate-dependent dioxygenase family...
  4. Cotsapas C, Speliotes E, Hatoum I, Greenawalt D, Dobrin R, Lum P, et al. Common body mass index-associated variants confer risk of extreme obesity. Hum Mol Genet. 2009;18:3502-7 pubmed publisher
    ..We found convincing association to the previously described locus including the FTO gene...
  5. Tönjes A, Zeggini E, Kovacs P, Böttcher Y, Schleinitz D, Dietrich K, et al. Association of FTO variants with BMI and fat mass in the self-contained population of Sorbs in Germany. Eur J Hum Genet. 2010;18:104-10 pubmed publisher
    The association between common variants in the FTO gene with weight, adiposity and body mass index (BMI) has now been widely replicated...
  6. Timpson N, Lindgren C, Weedon M, Randall J, Ouwehand W, Strachan D, et al. Adiposity-related heterogeneity in patterns of type 2 diabetes susceptibility observed in genome-wide association data. Diabetes. 2009;58:505-10 pubmed publisher
    ..In the "obese-type 2 diabetes" scan, FTO variants had the strongest type 2 diabetes effect (rs8050136: relative risk [RR] 1.49 [95% CI 1.34-1.66], P = 1...
  7. Peters U, North K, Sethupathy P, Buyske S, Haessler J, Jiao S, et al. A systematic mapping approach of 16q12.2/FTO and BMI in more than 20,000 African Americans narrows in on the underlying functional variation: results from the Population Architecture using Genomics and Epidemiology (PAGE) study. PLoS Genet. 2013;9:e1003171 pubmed publisher
    Genetic variants in intron 1 of the fat mass- and obesity-associated (FTO) gene have been consistently associated with body mass index (BMI) in Europeans...
  8. He M, Cornelis M, Franks P, Zhang C, Hu F, Qi L. Obesity genotype score and cardiovascular risk in women with type 2 diabetes mellitus. Arterioscler Thromb Vasc Biol. 2010;30:327-32 pubmed publisher
    ..A genetic risk score (GRS) was derived by summing risk alleles for each individual. Four polymorphisms (rs9939609 [FTO], rs11084753 [KCTD15], rs10838738 [MTCH2], and rs10938397 [GNPDA2]) showed nominally significant associations with ..
  9. Frayling T, Ong K. Piecing together the FTO jigsaw. Genome Biol. 2011;12:104 pubmed publisher
    Two recent studies of the FTO gene provide more information on how it affects body mass index.

More Information

Publications172 found, 100 shown here

  1. Thomsen M, Dahl M, Tybjærg Hansen A, Nordestgaard B. ?2-adrenergic receptor Thr164Ile polymorphism, obesity, and diabetes: comparison with FTO, MC4R, and TMEM18 polymorphisms in more than 64,000 individuals. J Clin Endocrinol Metab. 2012;97:E1074-9 pubmed publisher
    ..polymorphism associates with risk of obesity and diabetes and compared effect sizes with those of FTO(rs9939609), MC4R(rs17782313), and TMEM18(rs6548238)...
  2. Pitman R, Fong J, Billman P, Puri N. Knockdown of the fat mass and obesity gene disrupts cellular energy balance in a cell-type specific manner. PLoS ONE. 2012;7:e38444 pubmed publisher
    Recent studies suggest that FTO variants strongly correlate with obesity and mainly influence energy intake with little effect on the basal metabolic rate...
  3. Yan Q, Hong J, Gu W, Zhang Y, Liu Q, Su Y, et al. Association of the common rs9939609 variant of FTO gene with polycystic ovary syndrome in Chinese women. Endocrine. 2009;36:377-82 pubmed publisher
    Variations in the fat mass and obesity-associated (FTO) gene have recently been associated with obesity and type 2 diabetes mellitus among different ethnic populations...
  4. Delahanty L, Pan Q, Jablonski K, Watson K, McCaffery J, SHULDINER A, et al. Genetic predictors of weight loss and weight regain after intensive lifestyle modification, metformin treatment, or standard care in the Diabetes Prevention Program. Diabetes Care. 2012;35:363-6 pubmed publisher
    ..We tested genetic associations with weight loss and weight regain in the Diabetes Prevention Program, a randomized controlled trial of weight loss-inducing interventions (lifestyle and metformin) versus placebo...
  5. Han X, Luo Y, Ren Q, Zhang X, Wang F, Sun X, et al. Implication of genetic variants near SLC30A8, HHEX, CDKAL1, CDKN2A/B, IGF2BP2, FTO, TCF2, KCNQ1, and WFS1 in type 2 diabetes in a Chinese population. BMC Med Genet. 2010;11:81 pubmed publisher
    ..many novel genetic loci for type 2 diabetes (T2D); among these genes, CDKAL1, IGF2BP2, SLC30A8, CDKN2A/B, HHEX, FTO, TCF2, KCNQ1, and WFS1 are the most important...
  6. Wang J, Mei H, Chen W, Jiang Y, Sun W, Li F, et al. Study of eight GWAS-identified common variants for association with obesity-related indices in Chinese children at puberty. Int J Obes (Lond). 2012;36:542-7 pubmed publisher
    ..Eight SNPs within the NEGR1, TMEM18, GNPDA2, MTCH2, SH2B1, FTO, MC4R and KCTD15 genes were genotyped using matrix-assisted laser desorption/ionization-time of flight mass ..
  7. Corella D, Carrasco P, Sorli J, Coltell O, Ortega Azorín C, Guillen M, et al. Education modulates the association of the FTO rs9939609 polymorphism with body mass index and obesity risk in the Mediterranean population. Nutr Metab Cardiovasc Dis. 2012;22:651-8 pubmed publisher
    To define whether the rs9939609 FTO (fat mass and obesity associated) single nucleotide polymorphism (SNP) is associated with anthropometric measurements and its modulation by educational level in a Mediterranean population...
  8. Gulati P, Cheung M, Antrobus R, Church C, Harding H, Tung Y, et al. Role for the obesity-related FTO gene in the cellular sensing of amino acids. Proc Natl Acad Sci U S A. 2013;110:2557-62 pubmed publisher
    SNPs in the first intron of FTO (fat mass and obesity associated) are strongly associated with human obesity...
  9. Grau K, Hansen T, Holst C, Astrup A, Saris W, Arner P, et al. Macronutrient-specific effect of FTO rs9939609 in response to a 10-week randomized hypo-energetic diet among obese Europeans. Int J Obes (Lond). 2009;33:1227-34 pubmed publisher
    The A risk allele of rs9939609 of the fat mass- and obesity-associated gene (FTO) increases body fat mass...
  10. Labayen I, Ruiz J, Ortega F, Gottrand F, Huybrechts I, Dallongeville J, et al. Body size at birth modifies the effect of fat mass and obesity associated (FTO) rs9939609 polymorphism on adiposity in adolescents: the Healthy Lifestyle in Europe by Nutrition in Adolescence (HELENA) study. Br J Nutr. 2012;107:1498-504 pubmed publisher
    ..present study was intended to examine whether ponderal index (PI) at birth modifies the effect of the fat mass and obesity associated (FTO) rs9939609 polymorphism on adiposity in European adolescents...
  11. Rzehak P, Scherag A, Grallert H, Sausenthaler S, Koletzko S, Bauer C, et al. Associations between BMI and the FTO gene are age dependent: results from the GINI and LISA birth cohort studies up to age 6 years. Obes Facts. 2010;3:173-80 pubmed publisher
    The association between polymorphisms in intron 1 of the fat mass and obesity associated gene (FTO) and obesity-related traits is one of the most robust associations reported for complex traits and is established both in adults and ..
  12. Kilpeläinen T, Zillikens M, Stančákova A, Finucane F, Ried J, Langenberg C, et al. Genetic variation near IRS1 associates with reduced adiposity and an impaired metabolic profile. Nat Genet. 2011;43:753-60 pubmed publisher
    ..We confirmed a previously established adiposity locus in FTO (P = 3 × 10(-26)) and identified two new loci associated with body fat percentage, one near IRS1 (P = 4 × ..
  13. Tercjak M, Luczyński W, Wawrusiewicz Kurylonek N, Bossowski A. [The role of FTO gene polymorphism in the pathogenesis of obesity]. Pediatr Endocrinol Diabetes Metab. 2010;16:109-13 pubmed
    ..Over 100 genes are suspected to influence the obesity. One of those genes is FTO (fat mass and obesity-associated gene)...
  14. Wang K, Li W, Zhang C, Wang Z, Glessner J, Grant S, et al. A genome-wide association study on obesity and obesity-related traits. PLoS ONE. 2011;6:e18939 pubmed publisher
    ..For the binary trait of obesity, we found 16 genome-wide significant signals within the FTO gene (strongest signal at rs17817449, P = 2.5 × 10(-12))...
  15. Wojciechowski P, Lipowska A, Rys P, Ewens K, Franks S, Tan S, et al. Impact of FTO genotypes on BMI and weight in polycystic ovary syndrome: a systematic review and meta-analysis. Diabetologia. 2012;55:2636-2645 pubmed publisher
    b>FTO gene single nucleotide polymorphisms (SNPs) have been shown to be associated with obesity-related traits and type 2 diabetes...
  16. Pausova Z, Syme C, Abrahamowicz M, Xiao Y, Leonard G, Perron M, et al. A common variant of the FTO gene is associated with not only increased adiposity but also elevated blood pressure in French Canadians. Circ Cardiovasc Genet. 2009;2:260-9 pubmed publisher
    b>FTO is the first gene established as contributing to common forms of obesity. The gene is highly expressed in the hypothalamus and is thought to mediate this effect through its influence on energy homeostasis...
  17. Ng M, Tam C, So W, Ho J, Chan A, Lee H, et al. Implication of genetic variants near NEGR1, SEC16B, TMEM18, ETV5/DGKG, GNPDA2, LIN7C/BDNF, MTCH2, BCDIN3D/FAIM2, SH2B1, FTO, MC4R, and KCTD15 with obesity and type 2 diabetes in 7705 Chinese. J Clin Endocrinol Metab. 2010;95:2418-25 pubmed publisher
    ..polymorphisms at 12 loci (NEGR1, SEC16B, TMEM18, ETV5/DGKG, GNPDA2, LIN7C/BDNF, MTCH2, BCDIN3D/FAIM2, SH2B1, FTO, MC4R, and KCTD15) in 605 healthy adults, 1087 healthy adolescents and 6013 T2D patients from Hong Kong...
  18. Hertel J, Johansson S, Sonestedt E, Jonsson A, Lie R, Platou C, et al. FTO, type 2 diabetes, and weight gain throughout adult life: a meta-analysis of 41,504 subjects from the Scandinavian HUNT, MDC, and MPP studies. Diabetes. 2011;60:1637-44 pubmed publisher
    b>FTO is the most important polygene identified for obesity. We aimed to investigate whether a variant in FTO affects type 2 diabetes risk entirely through its effect on BMI and how FTO influences BMI across adult life span...
  19. Kilpeläinen T, Qi L, Brage S, Sharp S, Sonestedt E, Demerath E, et al. Physical activity attenuates the influence of FTO variants on obesity risk: a meta-analysis of 218,166 adults and 19,268 children. PLoS Med. 2011;8:e1001116 pubmed publisher
    The FTO gene harbors the strongest known susceptibility locus for obesity...
  20. den Hoed M, Ekelund U, Brage S, Grontved A, Zhao J, Sharp S, et al. Genetic susceptibility to obesity and related traits in childhood and adolescence: influence of loci identified by genome-wide association studies. Diabetes. 2010;59:2980-8 pubmed publisher
    ..Whereas the association of some variants may differ with age, the cumulative effect size is similar. ..
  21. Okuda M, Hinoda Y, Okayama N, Suehiro Y, Shirabe K, Sasaki S, et al. Association between the FTO gene and overweight in Japanese children and adolescents. Pediatr Diabetes. 2011;12:494-500 pubmed publisher
    The association between the fat mass- and obesity-associated (FTO) gene and a predisposition to obesity is inconsistent in adult Asian populations...
  22. Mei H, Chen W, Srinivasan S, Jiang F, Schork N, Murray S, et al. FTO influences on longitudinal BMI over childhood and adulthood and modulation on relationship between birth weight and longitudinal BMI. Hum Genet. 2010;128:589-96 pubmed publisher
    SNP rs9939609 within the fat mass and obesity associated gene (FTO) is strongly associated with adult body mass index (BMI). However, influences of FTO on longitudinal BMI change from childhood to adulthood have not been examined...
  23. Sentinelli F, Incani M, Coccia F, Capoccia D, Cambuli V, Romeo S, et al. Association of FTO polymorphisms with early age of obesity in obese Italian subjects. Exp Diabetes Res. 2012;2012:872176 pubmed publisher
    ..studies have provided evidence that several common variants within the fat mass- and obesity-associated (FTO) gene are significantly associated with obesity. Very limited data is available on FTO in the Italian population...
  24. Zhang X, Qi Q, Zhang C, Smith S, Hu F, Sacks F, et al. FTO genotype and 2-year change in body composition and fat distribution in response to weight-loss diets: the POUNDS LOST Trial. Diabetes. 2012;61:3005-11 pubmed publisher
    Recent evidence suggests that the fat mass and obesity-associated gene (FTO) genotype may interact with dietary intakes in relation to adiposity. We tested the effect of FTO variant on weight loss in response to 2-year diet interventions...
  25. Xi B, Mi J. FTO polymorphisms are associated with obesity but not with diabetes in East Asian populations: a meta-analysis. Biomed Environ Sci. 2009;22:449-57 pubmed publisher
    ..PubMed and Embase were searched for articles published up to March 2009. All studies on the association of FTO polymorphisms with obesity and type 2 diabetes were included...
  26. Li S, Zhao J, Luan J, Luben R, Rodwell S, Khaw K, et al. Cumulative effects and predictive value of common obesity-susceptibility variants identified by genome-wide association studies. Am J Clin Nutr. 2010;91:184-90 pubmed publisher
    ..094 and 0.866 kg for weight, and between 0.085 and 0.819 cm for waist circumference, with rs1121980 (FTO locus) showing the largest effect...
  27. Moleres A, Ochoa M, Rendo Urteaga T, Martínez González M, Azcona San Julián M, Martinez J, et al. Dietary fatty acid distribution modifies obesity risk linked to the rs9939609 polymorphism of the fat mass and obesity-associated gene in a Spanish case-control study of children. Br J Nutr. 2012;107:533-8 pubmed publisher
    The rs9939609 polymorphism of the fat mass and obesity-associated (FTO) gene has been widely associated with childhood obesity in several European cohorts. This association appears to be dependent on dietary macronutrients...
  28. Ruiz J, Labayen I, Ortega F, Legry V, Moreno L, Dallongeville J, et al. Attenuation of the effect of the FTO rs9939609 polymorphism on total and central body fat by physical activity in adolescents: the HELENA study. Arch Pediatr Adolesc Med. 2010;164:328-33 pubmed publisher
    To examine whether physical activity attenuates the effect of the FTO rs9939609 polymorphism on body fat estimates in adolescents. Cross-sectional study...
  29. Tews D, Fischer Posovszky P, Wabitsch M. Regulation of FTO and FTM expression during human preadipocyte differentiation. Horm Metab Res. 2011;43:17-21 pubmed publisher
    In genome-wide association studies (GWAS), polymorphisms in the first intron of FTO were shown to be associated with body fat mass. However, the functional properties of FTO and its nearby gene FTM are largely unknown...
  30. Wang L, Liu X, Luo X, Zeng M, Zuo L, Wang K. Genetic variants in the fat mass- and obesity-associated (FTO) gene are associated with alcohol dependence. J Mol Neurosci. 2013;51:416-24 pubmed publisher
    Variants (such as rs9939609) in the fat mass- and obesity-associated (FTO) gene have been associated with obesity, type 2 diabetes, some cancers, and alcohol consumption...
  31. Adeyemo A, Chen G, Zhou J, Shriner D, Doumatey A, Huang H, et al. FTO genetic variation and association with obesity in West Africans and African Americans. Diabetes. 2010;59:1549-54 pubmed publisher
    The FTO gene is one of the most consistently replicated loci for obesity. However, data from populations of African ancestry are limited...
  32. Razquin C, Marti A, Martinez J. Evidences on three relevant obesogenes: MC4R, FTO and PPAR?. Approaches for personalized nutrition. Mol Nutr Food Res. 2011;55:136-49 pubmed publisher
    ..the study of the effects of melanocortin 4 receptor, Peroxisome proliferator-activated receptor ? and fat mass and obesity associated (FTO) gene variants and their interactions with dietary intake, physical activity or drug ..
  33. Moore S, Gunter M, Daniel C, Reddy K, George P, Yurgalevitch S, et al. Common genetic variants and central adiposity among Asian-Indians. Obesity (Silver Spring). 2012;20:1902-8 pubmed publisher
    ..The T allele at the FTO rs3751812 locus was associated with increased waist circumference (per allele effect of +1.58 cm, P(trend) = 0...
  34. Stratigopoulos G, Padilla S, LeDuc C, Watson E, Hattersley A, McCarthy M, et al. Regulation of Fto/Ftm gene expression in mice and humans. Am J Physiol Regul Integr Comp Physiol. 2008;294:R1185-96 pubmed publisher
    ..studies (GWAS) in European populations have associated a approximately 47-kb region that contains part of the FTO gene with high body mass index (BMI). The functions of FTO and adjacent FTM in human biology are not clear...
  35. Han Z, Niu T, Chang J, Lei X, Zhao M, Wang Q, et al. Crystal structure of the FTO protein reveals basis for its substrate specificity. Nature. 2010;464:1205-9 pubmed publisher
    Recent studies have unequivocally associated the fat mass and obesity-associated (FTO) gene with the risk of obesity...
  36. Rodríguez López R, González Carpio M, Serrano M, Torres G, García de Cáceres M, Herrera T, et al. [Association of FTO gene polymorphisms and morbid obesity in the population of Extremadura (Spain)]. Endocrinol Nutr. 2010;57:203-9 pubmed publisher
    ..of the single nucleotide polymorphisms (SNPs) rs1861868 and rs9939609 of the fat-mass and obesity-associated FTO gene with an inherited predisposition to morbid obesity...
  37. Hardy R, Wills A, Wong A, Elks C, Wareham N, Loos R, et al. Life course variations in the associations between FTO and MC4R gene variants and body size. Hum Mol Genet. 2010;19:545-52 pubmed publisher
    ..We genotyped variants in FTO (rs9939609) and near MC4R (rs17782313) in 1240 men and 1239 women born in 1946 and participating in the MRC ..
  38. Hasselbalch A, Angquist L, Christiansen L, Heitmann B, Kyvik K, Sørensen T. A variant in the fat mass and obesity-associated gene (FTO) and variants near the melanocortin-4 receptor gene (MC4R) do not influence dietary intake. J Nutr. 2010;140:831-4 pubmed publisher
    We investigated the role of the fat mass and obesity associated gene (FTO) and variants near the melanocortin-4 receptor gene (MC4R) in modulating habitual intake of total energy and macronutrients, glycemic index, glycemic load, dietary ..
  39. Sonestedt E, Roos C, Gullberg B, Ericson U, Wirfalt E, Orho Melander M. Fat and carbohydrate intake modify the association between genetic variation in the FTO genotype and obesity. Am J Clin Nutr. 2009;90:1418-25 pubmed publisher
    The fat mass and obesity-associated gene (FTO) has been shown to be associated with obesity and to influence appetite regulation...
  40. Hubacek J, Stanek V, Gebauerová M, Pilipčincová A, Dlouhá D, Poledne R, et al. A FTO variant and risk of acute coronary syndrome. Clin Chim Acta. 2010;411:1069-72 pubmed publisher
    The FTO gene plays an important role in the determination of body weight and BMI and it has been suspected of being associated with all-case mortality...
  41. Sovio U, Mook Kanamori D, Warrington N, Lawrence R, Briollais L, Palmer C, et al. Association between common variation at the FTO locus and changes in body mass index from infancy to late childhood: the complex nature of genetic association through growth and development. PLoS Genet. 2011;7:e1001307 pubmed publisher
    An age-dependent association between variation at the FTO locus and BMI in children has been suggested...
  42. Jassim G, Fernø J, Theisen F, Haberhausen M, Christoforou A, Håvik B, et al. Association study of energy homeostasis genes and antipsychotic-induced weight gain in patients with schizophrenia. Pharmacopsychiatry. 2011;44:15-20 pubmed publisher
    ..We genotyped tagSNPs in several genes ( ADIPOQ, PRKAA1, PRKAA2, PRKAB1, PRKAG1, PRKAG2, PRKAG3, FTO and FABP3) that regulate lipid and energy homeostasis for their possible association to antipsychotic-induced ..
  43. Hotta K, Kitamoto T, Kitamoto A, Mizusawa S, Matsuo T, Nakata Y, et al. Association of variations in the FTO, SCG3 and MTMR9 genes with metabolic syndrome in a Japanese population. J Hum Genet. 2011;56:647-51 pubmed publisher
    ..are associated with variations in several genes, including NEGR1, SEC16B, TMEM18, ETV5, GNPDA2, BDNF, MTCH2, SH2B1, FTO, MAF, MC4R, KCTD15, SCG3, MTMR9, TFAP2B, MSRA, LYPLAL1, GCKR and FADS1...
  44. Vasan S, Fall T, Neville M, Antonisamy B, Fall C, Geethanjali F, et al. Associations of variants in FTO and near MC4R with obesity traits in South Asian Indians. Obesity (Silver Spring). 2012;20:2268-77 pubmed publisher
    Recent genome-wide association studies show that loci in FTO and melanocortin 4 receptor (MC4R) associate with obesity-related traits...
  45. Dwivedi O, Tabassum R, Chauhan G, Ghosh S, Marwaha R, Tandon N, et al. Common variants of FTO are associated with childhood obesity in a cross-sectional study of 3,126 urban Indian children. PLoS ONE. 2012;7:e47772 pubmed publisher
    b>FTO variants are robustly associated with obesity and related traits in many population and shown to have variable impact during life course...
  46. Bassols J, Prats Puig A, Vázquez Ruíz M, García González M, Martínez Pascual M, Avellí P, et al. Placental FTO expression relates to fetal growth. Int J Obes (Lond). 2010;34:1365-70 pubmed publisher
    The fat mass and obesity-associated gene (FTO) participates in the control of postnatal weight gain...
  47. Xi B, Shen Y, Zhang M, Liu X, Zhao X, Wu L, et al. The common rs9939609 variant of the fat mass and obesity-associated gene is associated with obesity risk in children and adolescents of Beijing, China. BMC Med Genet. 2010;11:107 pubmed publisher
    ..for type 2 diabetes susceptibility genes have confirmed that a common variant, rs9939609, in the fat mass and obesity associated (FTO) gene region is associated with body mass index (BMI) in European children and adults...
  48. Lewis S, Murad A, Chen L, Davey Smith G, Donovan J, Palmer T, et al. Associations between an obesity related genetic variant (FTO rs9939609) and prostate cancer risk. PLoS ONE. 2010;5:e13485 pubmed publisher
    ..association study of the relationship between a single nucleotide polymorphism known to be associated with obesity (FTO rs9939609) and prostate cancer...
  49. Corella D, Arnett D, Tucker K, Kabagambe E, Tsai M, Parnell L, et al. A high intake of saturated fatty acids strengthens the association between the fat mass and obesity-associated gene and BMI. J Nutr. 2011;141:2219-25 pubmed publisher
    Evidence that physical activity (PA) modulates the association between the fat mass and obesity-associated gene (FTO) and BMI is emerging; however, information about dietary factors modulating this association is scarce...
  50. Kivimaki M, Jokela M, Hamer M, Geddes J, Ebmeier K, Kumari M, et al. Examining overweight and obesity as risk factors for common mental disorders using fat mass and obesity-associated (FTO) genotype-instrumented analysis: The Whitehall II Study, 1985-2004. Am J Epidemiol. 2011;173:421-9 pubmed publisher
    ..obesity and common mental disorders (CMD) by utilizing the known relation between fat mass and obesity-associated (FTO) genotype and body mass index (BMI; weight (kg)/height (m)(2))...
  51. Rivera M, Cohen Woods S, Kapur K, Breen G, Ng M, Butler A, et al. Depressive disorder moderates the effect of the FTO gene on body mass index. Mol Psychiatry. 2012;17:604-11 pubmed publisher
    ..Variation in the FTO (fat mass and obesity associated) gene has been shown to contribute to common forms of human obesity...
  52. Johnson L, van Jaarsveld C, Emmett P, Rogers I, Ness A, Hattersley A, et al. Dietary energy density affects fat mass in early adolescence and is not modified by FTO variants. PLoS ONE. 2009;4:e4594 pubmed publisher
    ..Children with the FTO (rs9939609) variant that increases the risk of obesity may have a higher susceptibility to the effects of DED ..
  53. Lurie G, Gaudet M, Spurdle A, Carney M, Wilkens L, Yang H, et al. The obesity-associated polymorphisms FTO rs9939609 and MC4R rs17782313 and endometrial cancer risk in non-Hispanic white women. PLoS ONE. 2011;6:e16756 pubmed publisher
    ..Several independent genome-wide association studies recently identified two common polymorphisms, FTO rs9939609 and MC4R rs17782313, that are linked to increased body weight and obesity...
  54. Karra E, O Daly O, Choudhury A, Yousseif A, Millership S, Neary M, et al. A link between FTO, ghrelin, and impaired brain food-cue responsivity. J Clin Invest. 2013;123:3539-51 pubmed publisher
    Polymorphisms in the fat mass and obesity-associated gene (FTO) are associated with human obesity and obesity-prone behaviors, including increased food intake and a preference for energy-dense foods...
  55. Ewens K, Jones M, Ankener W, Stewart D, Urbanek M, Dunaif A, et al. FTO and MC4R gene variants are associated with obesity in polycystic ovary syndrome. PLoS ONE. 2011;6:e16390 pubmed publisher
    ..While not associated with PCOS itself, five SNPs in FTO and two in MC4R were associated with BMI as assessed with a quantitative-TDT analysis, several of which replicated ..
  56. Phillips C, Kesse Guyot E, McManus R, Hercberg S, Lairon D, Planells R, et al. High dietary saturated fat intake accentuates obesity risk associated with the fat mass and obesity-associated gene in adults. J Nutr. 2012;142:824-31 pubmed publisher
    Fat mass and obesity-associated (FTO) is the strongest genetic determinant of obesity identified to date. Dietary fat is a key environmental factor that may interact with genotype to affect risk of obesity and metabolic syndrome (MetS)...
  57. Deliard S, Panossian S, Mentch F, Kim C, Hou C, Frackelton E, et al. The missense variation landscape of FTO, MC4R, and TMEM18 in obese children of African Ancestry. Obesity (Silver Spring). 2013;21:159-63 pubmed publisher
    Common variation at the loci harboring fat mass and obesity (FTO), melanocortin receptor 4 (MC4R), and transmembrane protein 18 (TMEM18) is consistently reported as being statistically most strongly associated with obesity...
  58. Yajnik C, Janipalli C, Bhaskar S, Kulkarni S, Freathy R, Prakash S, et al. FTO gene variants are strongly associated with type 2 diabetes in South Asian Indians. Diabetologia. 2009;52:247-52 pubmed publisher
    Variants of the FTO (fat mass and obesity associated) gene are associated with obesity and type 2 diabetes in white Europeans, but these associations are not consistent in Asians...
  59. Wehr E, Schweighofer N, Möller R, Giuliani A, Pieber T, Obermayer Pietsch B. Association of FTO gene with hyperandrogenemia and metabolic parameters in women with polycystic ovary syndrome. Metabolism. 2010;59:575-80 pubmed publisher
    Variants in the fat mass and obesity-associated gene (FTO) are associated with obesity and type 2 diabetes mellitus. Women with polycystic ovary syndrome (PCOS) are frequently affected by obesity and impaired glucose tolerance...
  60. Scott R, Bailey M, Moran C, Wilson R, Fuku N, Tanaka M, et al. FTO genotype and adiposity in children: physical activity levels influence the effect of the risk genotype in adolescent males. Eur J Hum Genet. 2010;18:1339-43 pubmed publisher
    Studies of the fat mass and obesity-associated (FTO) gene provide compelling evidence of genetic variation in the general population that influences fat levels and obesity risk...
  61. Yang J, Loos R, Powell J, Medland S, Speliotes E, Chasman D, et al. FTO genotype is associated with phenotypic variability of body mass index. Nature. 2012;490:267-72 pubmed publisher
    ..We report evidence that the single nucleotide polymorphism (SNP) rs7202116 at the FTO gene locus, which is known to be associated with obesity (as measured by mean BMI for each rs7202116 genotype), is ..
  62. Stratigopoulos G, Martin Carli J, O Day D, Wang L, LeDuc C, Lanzano P, et al. Hypomorphism for RPGRIP1L, a ciliary gene vicinal to the FTO locus, causes increased adiposity in mice. Cell Metab. 2014;19:767-79 pubmed publisher
    Common polymorphisms in the first intron of FTO are associated with increased body weight in adults...
  63. Ho A, Stein J, Hua X, Lee S, Hibar D, Leow A, et al. A commonly carried allele of the obesity-related FTO gene is associated with reduced brain volume in the healthy elderly. Proc Natl Acad Sci U S A. 2010;107:8404-9 pubmed publisher
    A recently identified variant within the fat mass and obesity-associated (FTO) gene is carried by 46% of Western Europeans and is associated with an approximately 1...
  64. Bressler J, Kao W, Pankow J, Boerwinkle E. Risk of type 2 diabetes and obesity is differentially associated with variation in FTO in whites and African-Americans in the ARIC study. PLoS ONE. 2010;5:e10521 pubmed publisher
    Single nucleotide polymorphisms (SNPs) in the fat mass and obesity associated (FTO) gene are associated with body mass index (BMI) in populations of European descent...
  65. Keller L, Xu W, Wang H, Winblad B, Fratiglioni L, Graff C. The obesity related gene, FTO, interacts with APOE, and is associated with Alzheimer's disease risk: a prospective cohort study. J Alzheimers Dis. 2011;23:461-9 pubmed publisher
    The FTO gene has been shown to have a small but robust effect on body mass index (BMI) and to increase the risk for diabetes...
  66. Wang H, Dong S, Xu H, Qian J, Yang J. Genetic variants in FTO associated with metabolic syndrome: a meta- and gene-based analysis. Mol Biol Rep. 2012;39:5691-8 pubmed publisher
    The objective of this study was to examine the effect of genetic variants in fat mass and obesity associated (FTO) gene on metabolic syndrome (MetS)...
  67. Kowalska I, Adamska A, Malecki M, Karczewska Kupczewska M, Nikolajuk A, Szopa M, et al. Impact of the FTO gene variation on fat oxidation and its potential influence on body weight in women with polycystic ovary syndrome. Clin Endocrinol (Oxf). 2012;77:120-5 pubmed publisher
    ..It has recently been shown that the FTO gene modifies weight, fat mass and insulin sensitivity in women with PCOS, where its role might be larger than in ..
  68. Kaklamani V, Yi N, Sadim M, Siziopikou K, Zhang K, Xu Y, et al. The role of the fat mass and obesity associated gene (FTO) in breast cancer risk. BMC Med Genet. 2011;12:52 pubmed publisher
    Obesity has been shown to increase breast cancer risk. FTO is a novel gene which has been identified through genome wide association studies (GWAS) to be related to obesity...
  69. Liu G, Zhu H, Dong Y, Podolsky R, Treiber F, Snieder H. Influence of common variants in FTO and near INSIG2 and MC4R on growth curves for adiposity in African- and European-American youth. Eur J Epidemiol. 2011;26:463-73 pubmed publisher
    Recent genome-wide association (GWA) studies identified several common variants for obesity: rs9939609 in FTO, rs7566605 near INSIG2 and both rs17782313 and rs17700633 near the MC4R gene...
  70. Elks C, Loos R, Sharp S, Langenberg C, Ring S, Timpson N, et al. Genetic markers of adult obesity risk are associated with greater early infancy weight gain and growth. PLoS Med. 2010;7:e1000284 pubmed publisher
    ..Eight variants that showed individual associations with childhood BMI (in/near: FTO, MC4R, TMEM18, GNPDA2, KCTD15, NEGR1, BDNF, and ETV5) were used to derive an "obesity-risk-allele score" ..
  71. Bravard A, Lefai E, Meugnier E, Pesenti S, Disse E, Vouillarmet J, et al. FTO is increased in muscle during type 2 diabetes, and its overexpression in myotubes alters insulin signaling, enhances lipogenesis and ROS production, and induces mitochondrial dysfunction. Diabetes. 2011;60:258-68 pubmed publisher
    A strong association between genetic variants and obesity was found for the fat mass and obesity-associated gene (FTO)...
  72. Ortega Azorín C, Sorli J, Asensio E, Coltell O, Martinez Gonzalez M, Salas Salvado J, et al. Associations of the FTO rs9939609 and the MC4R rs17782313 polymorphisms with type 2 diabetes are modulated by diet, being higher when adherence to the Mediterranean diet pattern is low. Cardiovasc Diabetol. 2012;11:137 pubmed publisher
    Although the fat mass and obesity (FTO) and melanocortin-4 receptor (MC4R) genes have been consistently associated with obesity risk, the association between the obesity-risk alleles with type 2 diabetes is still controversial...
  73. Wu L, Xi B, Zhang M, Shen Y, Zhao X, Cheng H, et al. Associations of six single nucleotide polymorphisms in obesity-related genes with BMI and risk of obesity in Chinese children. Diabetes. 2010;59:3085-9 pubmed publisher
    ..rs7138803, rs1805081, rs6499640, rs17782313, rs6265, and rs10938397, in or near obesity-related genes FAIM2, NPC1, FTO, MC4R, BDNF, and GNPDA2, respectively) because of the relatively high minor allele frequencies in Chinese ..
  74. Elliott K, Chapman K, Day Williams A, Panoutsopoulou K, Southam L, Lindgren C, et al. Evaluation of the genetic overlap between osteoarthritis with body mass index and height using genome-wide association scan data. Ann Rheum Dis. 2013;72:935-41 pubmed publisher
    ..in the arcOGEN GWAS was also associated with osteoarthritis in the independent dataset: rs12149832, within the FTO gene (combined p=2.3×10(-5)). As expected, this signal was attenuated when we adjusted for BMI...
  75. McCaffery J, Papandonatos G, Huggins G, Peter I, Kahn S, Knowler W, et al. FTO predicts weight regain in the Look AHEAD clinical trial. Int J Obes (Lond). 2013;37:1545-52 pubmed publisher
    ..However, fat mass and obesity associated gene (FTO) rs3751812 predicted weight regain within DSE (1.56?kg per risk allele, P=0...
  76. Bauer F, Elbers C, Adan R, Loos R, Onland Moret N, Grobbee D, et al. Obesity genes identified in genome-wide association studies are associated with adiposity measures and potentially with nutrient-specific food preference. Am J Clin Nutr. 2009;90:951-9 pubmed publisher
    ..They were in or near to 6 loci: FTO, MC4R, KCTD15, MTCH2, NEGR1, and BDNF. Five SNPs were associated with dietary intake (P < 0...
  77. Liem E, Vonk J, Sauer P, van der Steege G, Oosterom E, Stolk R, et al. Influence of common variants near INSIG2, in FTO, and near MC4R genes on overweight and the metabolic profile in adolescence: the TRAILS (TRacking Adolescents' Individual Lives Survey) Study. Am J Clin Nutr. 2010;91:321-8 pubmed publisher
    ..regression analyses to assess the influence of candidate single nucleotide polymorphisms near the INSIG2, in the FTO, and near the MC4R genes and repeated-measures analyses of available body mass index (BMI) and skinfold thickness ..
  78. Jowett J, Curran J, Johnson M, Carless M, Goring H, Dyer T, et al. Genetic variation at the FTO locus influences RBL2 gene expression. Diabetes. 2010;59:726-32 pubmed publisher
    ..Variant rs8050136 lies within intron 1 of the FTO gene on chromosome 16 and marks a locus strongly associated with type 2 diabetes and obesity and widely replicated ..
  79. Kaakinen M, Läärä E, Pouta A, Hartikainen A, Laitinen J, Tammelin T, et al. Life-course analysis of a fat mass and obesity-associated (FTO) gene variant and body mass index in the Northern Finland Birth Cohort 1966 using structural equation modeling. Am J Epidemiol. 2010;172:653-65 pubmed publisher
    The association between variation in the fat mass and obesity-associated (FTO) gene and adulthood body mass index (BMI; weight (kg)/height (m)(2)) is well-replicated...
  80. Li M, Liu Y, Xu P, Ye M, Liu Y. [Association of the rs9939609 polymorphism of FTO gene with overweight or obesity in Hazakh children]. Zhonghua Yi Xue Yi Chuan Xue Za Zhi. 2010;27:678-81 pubmed publisher
    To study the association of rs9939609 polymorphism of the fat mass and obesity associated gene (FTO) with overweight or obesity in Hazakh children...
  81. Iles M, Law M, Stacey S, Han J, Fang S, Pfeiffer R, et al. A variant in FTO shows association with melanoma risk not due to BMI. Nat Genet. 2013;45:428-32, 432e1 pubmed publisher
    ..This revealed an association between several SNPs in intron 8 of the FTO gene, including rs16953002, which replicated using 12,313 cases and 55,667 controls of European ancestry from ..
  82. Scherag A, Dina C, Hinney A, Vatin V, Scherag S, Vogel C, et al. Two new Loci for body-weight regulation identified in a joint analysis of genome-wide association studies for early-onset extreme obesity in French and german study groups. PLoS Genet. 2010;6:e1000916 pubmed publisher
    ..Apart from previously identified FTO, MC4R, and TMEM18, we detected two new loci for obesity: one in SDCCAG8 (serologically defined colon cancer antigen ..
  83. Huang W, Sun Y, Sun J. Combined effects of FTO rs9939609 and MC4R rs17782313 on obesity and BMI in Chinese Han populations. Endocrine. 2011;39:69-74 pubmed publisher
    Genetic variants of FTO and MC4R have been linked with obesity and T2DM in populations of Europeans...
  84. Mitchell J, Church T, Rankinen T, Earnest C, Sui X, Blair S. FTO genotype and the weight loss benefits of moderate intensity exercise. Obesity (Silver Spring). 2010;18:641-3 pubmed publisher
    The fat mass and obesity-associated (FTO) gene was genotyped for the participants in the Dose-Response to Exercise in postmenopausal Women (DREW) trial and analyses were performed to determine whether an FTO variant was associated with ..
  85. Attaoua R, Ait el Mkadem S, Lautier C, Kaouache S, Renard E, Brun J, et al. Association of the FTO gene with obesity and the metabolic syndrome is independent of the IRS-2 gene in the female population of Southern France. Diabetes Metab. 2009;35:476-83 pubmed publisher
    ..The objective of the present study was to investigate the genetic association of the fat-mass-and-obesity-associated (FTO) gene in obese women in the presence of the known influential role of the insulin receptor substrate 2 (IRS-2) gene...
  86. Zavattari P, Loche A, Pilia S, Ibba A, Moi L, Guzzetti C, et al. rs9939609 in the FTO gene is associated with obesity but not with several biochemical parameters in Sardinian obese children. Ann Hum Genet. 2011;75:648-54 pubmed publisher
    ..association of the intronic single nucleotide polymorphism (SNP) rs9939609 of the fat mass and obesity-associated (FTO) gene with obesity and with a number of obesity-related features...
  87. Zeggini E, Panoutsopoulou K, Southam L, Rayner N, Day Williams A, Lopes M, et al. Identification of new susceptibility loci for osteoarthritis (arcOGEN): a genome-wide association study. Lancet. 2012;380:815-23 pubmed publisher
    ..One of the signals close to genome-wide significance was within the FTO gene, which is involved in regulation of bodyweight-a strong risk factor for osteoarthritis...
  88. Ibba A, Pilia S, Zavattari P, Loche A, Guzzetti C, Casini M, et al. The role of FTO genotype on eating behavior in obese Sardinian children and adolescents. J Pediatr Endocrinol Metab. 2013;26:539-44 pubmed publisher
    We aimed to study the influence of the fat mass and obesity-associated (FTO) gene on eating behavior in 412 obese Sardinian children and adolescents...
  89. Li T, Wu K, You L, Xing X, Wang P, Cui L, et al. Common variant rs9939609 in gene FTO confers risk to polycystic ovary syndrome. PLoS ONE. 2013;8:e66250 pubmed publisher
    Fat mass and obesity-associated gene (FTO) has been associated with obesity, especially the common variant rs9939609...
  90. Wen J, Rönn T, Olsson A, Yang Z, Lu B, Du Y, et al. Investigation of type 2 diabetes risk alleles support CDKN2A/B, CDKAL1, and TCF7L2 as susceptibility genes in a Han Chinese cohort. PLoS ONE. 2010;5:e9153 pubmed publisher
    ..61 (1.19-2.18) P = 2.3 * 10(-3). Only nominal phenotype associations were observed, notably for rs8050136 in FTO and fasting plasma glucose (P = 0.002), postprandial plasma glucose (P = 0...
  91. Benedict C, Jacobsson J, Rönnemaa E, Sällman Almén M, Brooks S, Schultes B, et al. The fat mass and obesity gene is linked to reduced verbal fluency in overweight and obese elderly men. Neurobiol Aging. 2011;32:1159.e1-5 pubmed publisher
    Humans carrying the prevalent rs9939609 A allele of the fat mass and obesity-associated (FTO) gene are more susceptible to developing obesity than noncarries...