FKBP1B

Summary

Gene Symbol: FKBP1B
Description: FK506 binding protein 1B
Alias: FKBP12.6, FKBP1L, OTK4, PKBP1L, PPIase, peptidyl-prolyl cis-trans isomerase FKBP1B, 12.6 kDa FK506-binding protein, 12.6 kDa FKBP, FK506 binding protein 1B, 12.6 kDa, FK506-binding protein 12.6, FKBP-12.6, FKBP-1B, PPIase FKBP1B, calstabin 2, h-FKBP-12, immunophilin FKBP12.6, rotamase
Species: human

Top Publications

  1. ncbi FKBP binding characteristics of cardiac microsomes from diverse vertebrates
    L H Jeyakumar
    Department of Biological Sciences, Vanderbilt University, Nashville, Tennessee 37235, USA
    Biochem Biophys Res Commun 281:979-86. 2001
  2. ncbi A cyclophilin-like peptidyl-prolyl cis/trans isomerase from Legionella pneumophila--characterization, molecular cloning and overexpression
    B Schmidt
    Max Planck Gesellschaft, Arbeitsgruppe Enzymologie der Peptidbindung, Halle Saale, Germany
    Mol Microbiol 21:1147-60. 1996
  3. pmc Mapping the ryanodine receptor FK506-binding protein subunit using fluorescence resonance energy transfer
    Razvan L Cornea
    Department of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, Minneapolis, Minnesota 55455, USA
    J Biol Chem 285:19219-26. 2010
  4. ncbi Overexpression of FK506-binding protein FKBP12.6 in cardiomyocytes reduces ryanodine receptor-mediated Ca(2+) leak from the sarcoplasmic reticulum and increases contractility
    J Prestle
    Department of Cardiology and Pneumology, Georg August University Goettingen, Goettingen, Germany
    Circ Res 88:188-94. 2001
  5. ncbi The conserved sites for the FK506-binding proteins in ryanodine receptors and inositol 1,4,5-trisphosphate receptors are structurally and functionally different
    G Bultynck
    Laboratorium voor Fysiologie, K U Leuven Campus Gasthuisberg O N, Herestraat 49, B 3000 Leuven, Belgium
    J Biol Chem 276:47715-24. 2001
  6. pmc Three-dimensional visualization of FKBP12.6 binding to an open conformation of cardiac ryanodine receptor
    Manjuli Rani Sharma
    Wadsworth Center, New York State Department of Health, School of Public Health, State University of New York at Albany, Albany, New York 12201 0509, USA
    Biophys J 90:164-72. 2006
  7. ncbi Archaeal peptidyl prolyl cis-trans isomerases (PPIases) update 2004
    Tadashi Maruyama
    Japan Marine Science and Technology Center, 2 15 Natsushima cho, Yokosuka shi, Kanagawa 237 0061, Japan
    Front Biosci 9:1680-720. 2004
  8. pmc Developmental regulation and coordinate reexpression of FKBP65 with extracellular matrix proteins after lung injury suggest a specialized function for this endoplasmic reticulum immunophilin
    Charles E Patterson
    Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas 75390 9039, USA
    Cell Stress Chaperones 10:285-95. 2005
  9. ncbi Altered stoichiometry of FKBP12.6 versus ryanodine receptor as a cause of abnormal Ca(2+) leak through ryanodine receptor in heart failure
    M Yano
    Second Department of Internal Medicine, Yamaguchi University School of Medicine, Yamaguchi, Japan
    Circulation 102:2131-6. 2000
  10. pmc Localization of PKA phosphorylation site, Ser(2030), in the three-dimensional structure of cardiac ryanodine receptor
    Peter P Jones
    Department of Physiology and Biophysics, Libin Cardiovascular Institute of Alberta, University of Calgary, Calgary, Alberta, Canada T2N 4N1
    Biochem J 410:261-70. 2008

Research Grants

  1. ALLOSTERIC SITE STRUCTURES OF CARDIOVASCULAR CHANNELS
    Arthur Karlin; Fiscal Year: 2011
  2. RAZVAN LIVIU CORNEA; Fiscal Year: 2016
  3. Philip W Landfield; Fiscal Year: 2016
  4. Chad A Dickey; Fiscal Year: 2016
  5. THE ROLE OF PIN1 IN MITOSIS WITH DESIGNED INHIBITORS
    FELICIA ETZKORN; Fiscal Year: 2002
  6. SUBSTRATES FOR PEPTIDYL PROLYL CIS-TRANS ISOMERASE ASSAY
    Roger Tung; Fiscal Year: 1990
  7. ANDREW ROBERT MARKS; Fiscal Year: 2016
  8. Lipid electrophile adduction of Pin1 and effects on substrate binding &activity
    Christopher D Aluise; Fiscal Year: 2013
  9. Regulation of Breast Cancer Growth by MLK-3
    AJAY NMN RANA; Fiscal Year: 2013
  10. Yeast Ess1, a Conserved PPlase Essential for Mitosis
    Steven D Hanes; Fiscal Year: 2010

Detail Information

Publications308 found, 100 shown here

  1. ncbi FKBP binding characteristics of cardiac microsomes from diverse vertebrates
    L H Jeyakumar
    Department of Biological Sciences, Vanderbilt University, Nashville, Tennessee 37235, USA
    Biochem Biophys Res Commun 281:979-86. 2001
    ..6. Dog is the exception. It can now be concluded that the association of FKBP isoforms with RyR2 is widely conserved in the hearts of different species of vertebrates...
  2. ncbi A cyclophilin-like peptidyl-prolyl cis/trans isomerase from Legionella pneumophila--characterization, molecular cloning and overexpression
    B Schmidt
    Max Planck Gesellschaft, Arbeitsgruppe Enzymologie der Peptidbindung, Halle Saale, Germany
    Mol Microbiol 21:1147-60. 1996
    ..Like human cyclophilin, the L. p. Cyp18 exhibits nuclease activity, but this enzymatic activity does not appear to be linked with the native structure of the protein...
  3. pmc Mapping the ryanodine receptor FK506-binding protein subunit using fluorescence resonance energy transfer
    Razvan L Cornea
    Department of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, Minneapolis, Minnesota 55455, USA
    J Biol Chem 285:19219-26. 2010
    ..FRET mapping of RyR-bound FKBP12.6 is consistent with the predictions of a previous cryoelectron microscopy study and strongly supports the proposed structural model...
  4. ncbi Overexpression of FK506-binding protein FKBP12.6 in cardiomyocytes reduces ryanodine receptor-mediated Ca(2+) leak from the sarcoplasmic reticulum and increases contractility
    J Prestle
    Department of Cardiology and Pneumology, Georg August University Goettingen, Goettingen, Germany
    Circ Res 88:188-94. 2001
    ..Taken together, these data suggest that FKBP12.6 stabilizes the closed conformation state of RyR2. This may reduce diastolic SR-Ca(2+) leak and consequently increase SR-Ca(2+) release and myocyte shortening...
  5. ncbi The conserved sites for the FK506-binding proteins in ryanodine receptors and inositol 1,4,5-trisphosphate receptors are structurally and functionally different
    G Bultynck
    Laboratorium voor Fysiologie, K U Leuven Campus Gasthuisberg O N, Herestraat 49, B 3000 Leuven, Belgium
    J Biol Chem 276:47715-24. 2001
    ..Structural differences in the FKBP-binding site of RyRs and IP(3)Rs may contribute to the occurrence of a stable interaction between RyR isoforms and FKBPs and to the absence of such interaction with IP(3)Rs...
  6. pmc Three-dimensional visualization of FKBP12.6 binding to an open conformation of cardiac ryanodine receptor
    Manjuli Rani Sharma
    Wadsworth Center, New York State Department of Health, School of Public Health, State University of New York at Albany, Albany, New York 12201 0509, USA
    Biophys J 90:164-72. 2006
    ..A thorough understanding of the structural basis of RyR2-FKBP12.6 interaction should aid in understanding the roles that have been proposed for FKBP12.6 in heart failure and in certain forms of sudden cardiac death...
  7. ncbi Archaeal peptidyl prolyl cis-trans isomerases (PPIases) update 2004
    Tadashi Maruyama
    Japan Marine Science and Technology Center, 2 15 Natsushima cho, Yokosuka shi, Kanagawa 237 0061, Japan
    Front Biosci 9:1680-720. 2004
    ..This is a cyclosporin A (CsA) sensitive CyP with a molecular weight of 19.4 kDa. The PPIase activity and CsA sensitivity of HbsCyP19 is higher at higher salt concentration in the medium...
  8. pmc Developmental regulation and coordinate reexpression of FKBP65 with extracellular matrix proteins after lung injury suggest a specialized function for this endoplasmic reticulum immunophilin
    Charles E Patterson
    Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas 75390 9039, USA
    Cell Stress Chaperones 10:285-95. 2005
    ..The response to injury, which may be in part a direct response to TGF-beta1, assures the presence of FKBP65 in the ER of cells actively producing components of the extracellular matrix...
  9. ncbi Altered stoichiometry of FKBP12.6 versus ryanodine receptor as a cause of abnormal Ca(2+) leak through ryanodine receptor in heart failure
    M Yano
    Second Department of Internal Medicine, Yamaguchi University School of Medicine, Yamaguchi, Japan
    Circulation 102:2131-6. 2000
    ..Here, we report a novel mechanism of cardiac dysfunction revealed by assessing the functional interaction of FK506-binding protein (FKBP12.6) with the cardiac ryanodine receptor (RyR) in a canine model of pacing-induced heart failure...
  10. pmc Localization of PKA phosphorylation site, Ser(2030), in the three-dimensional structure of cardiac ryanodine receptor
    Peter P Jones
    Department of Physiology and Biophysics, Libin Cardiovascular Institute of Alberta, University of Calgary, Calgary, Alberta, Canada T2N 4N1
    Biochem J 410:261-70. 2008
    ..6 binding. On the basis of the three-dimensional localizations of a number of residues or regions, a model for the subunit organization in the structure of RyR2 is proposed...
  11. ncbi Central domain of the human cardiac muscle ryanodine receptor does not mediate interaction with FKBP12.6
    Spyros Zissimopoulos
    Wales Heart Research Institute, Department of Cardiology, Wales College of Medicine, Cardiff University, UK
    Cell Biochem Biophys 43:203-19. 2005
    ..Further structural analysis will be necessary to unravel this intricate signaling system and the current model of FKBP12-RyR interaction via a single, central RyR epitope may therefore require revision...
  12. ncbi Archaeal peptidyl prolyl cis-trans isomerases (PPIases)
    T Maruyama
    Marine Biotechnology Institute, Kamaishi Laboratories, 3 75 1 Heita, Kamaishi shi, Iwate 026 0001, Japan
    Front Biosci 5:D821-36. 2000
    ..It is a cyclosporin A (CsA) sensitive CyP with a MW of 19.4kDa. The PPIase activity and CsA sensitivity of this CyP is higher at higher salt concentration in the medium...
  13. doi Identification of functional FKB protein in Echinococcus granulosus: its involvement in the protoscolicidal action of rapamycin derivates and in calcium homeostasis
    Andrea C Cumino
    Laboratorio de Zoonosis Parasitarias, Departamento de Biologia, Facultad de Ciencias Exactas y Naturales, Universidad Nacional de Mar del Plata UNMdP, Funes 3350, Nivel Cero, 7600 Mar del Plata, Argentina
    Int J Parasitol 40:651-61. 2010
    ..These proteins display a peptidyl-prolyl rotamase function that is believed to catalyze protein folding and they are well-validated anti-proliferative drug targets ..
  14. pmc Dissociation of FKBP12.6 from ryanodine receptor type 2 is regulated by cyclic ADP-ribose but not beta-adrenergic stimulation in mouse cardiomyocytes
    Xu Zhang
    National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, 15 Datun Road, Chaoyang District, Beijing 100101, China
    Cardiovasc Res 84:253-62. 2009
    ..6 affects Ca(2+) sparks and mediates the inotropic action of isoproterenol (ISO), and to investigate the underlying mechanisms of cyclic ADP-ribose (cADPR) regulation of Ca(2+) sparks...
  15. ncbi Characterization of high molecular weight FK-506 binding activities reveals a novel FK-506-binding protein as well as a protein complex
    G Wiederrecht
    Department of Immunology Research, Merck Research Laboratories, Rahway, New Jersey 07065
    J Biol Chem 267:21753-60. 1992
    ..upon calmodulin (CaM) for formation of the complex and demonstrates that the peptidyl-prolyl cis-trans isomerase (PPIase) activity of FKBP12 is not required for binding of FKBP12...
  16. pmc A novel FK506- and rapamycin-binding protein (FPR3 gene product) in the yeast Saccharomyces cerevisiae is a proline rotamase localized to the nucleolus
    B M Benton
    Department of Molecular and Cell Biology, University of California, Berkeley 94720 3202
    J Cell Biol 127:623-39. 1994
    The gene (FPR3) encoding a novel type of peptidylpropyl-cis-trans-isomerase (PPIase) was isolated during a search for previously unidentified nuclear proteins in Saccharomyces cerevisiae...
  17. ncbi FKBP-type peptidyl-prolyl cis-trans isomerase from a sulfur-dependent hyperthermophilic archaeon, Thermococcus sp. KS-1
    T Iida
    Marine Biotechnology Institute, Kamaishi Laboratories, 3 75 1 Heita, Kamaishi, Iwate 026 0001, Japan
    Gene 222:249-55. 1998
    A gene encoding an FK506 binding protein (FKBP)-type peptidyl-prolyl cis-trans isomerase (PPIase) was cloned from a hyperthermophilic archaeon, Thermococcus sp. KS-1, and sequenced...
  18. ncbi FK506 binding protein from a thermophilic archaeon, Methanococcus thermolithotrophicus, has chaperone-like activity in vitro
    M Furutani
    Kamaishi Laboratories, Marine Biotechnology Institute Co Ltd, 3 75 1 Heita Kamaishi, Iwate 026 0001, Japan
    Biochemistry 39:453-62. 2000
    ..MTFK exhibited FK506 sensitive PPIase (peptidyl prolyl cis-trans isomerase) activity which accelerated the speed of ribonuclease T1 refolding, which is ..
  19. ncbi FK506-binding protein-type peptidyl-prolyl cis-trans isomerase from a halophilic archaeum, Halobacterium cutirubrum
    T Iida
    Marine Biotechnology Institute, Kamaishi Laboratories, 3 75 1 Heita, Kamaishi, 026 0001, Iwate, Japan
    Gene 256:319-26. 2000
    ..archaeum, Halobacterium cutirubrum, has been shown to have a cyclophilin-type peptidyl-prolyl cis-trans isomerase (PPIase)...
  20. ncbi Wheat FKBP73 functions in vitro as a molecular chaperone independently of its peptidyl prolyl cis-trans isomerase activity
    Isaac Kurek
    Dep artment of Plant Sciences, Tel Aviv University, Tel Aviv 69978, Israel
    Planta 215:119-26. 2002
    ..In vitro studies indicated that wFKBP73 possesses PPIase activity, binds calmodulin and forms a heterocomplex with mammalian p23 and wheat Hsp90 in wheat-germ lysate...
  21. ncbi A kinetically trapped intermediate of FK506 binding protein forms in vitro: chaperone machinery dominates protein folding in vivo
    Martin A Wear
    Institute of Structural and Molecular Biology, Structural Biochemistry Group, The University of Edinburgh, Michael Swann Building, King s Buildings, Mayfield Road, Edinburgh EH9 3JR, UK
    Protein Expr Purif 51:80-95. 2007
    ..All three natively purified proteins have, within experimental error, the same peptidyl-prolyl isomerase (PPIase) activity (k(cat)/K(m) approximately 1 x 10(6)M(-1)s(-1)), and bind a natural inhibitor, rapamycin, with the same ..
  22. ncbi A novel role for the immunophilin FKBP52 in copper transport
    Reiko Sanokawa-Akakura
    Department of Biochemistry and Molecular Biology, University of Medicine and Dentistry of New Jersey New Jersey Medical School, 185 South Orange Avenue, Newark, NJ 07103, USA
    J Biol Chem 279:27845-8. 2004
    FK506-binding protein 52 (FKBP52) is an immunophilin that possesses peptidylprolyl cis/trans-isomerase (PPIase) activity and is a component of a subclass of steroid hormone receptor complexes...
  23. ncbi Changes in peptidyl-prolyl cis/trans isomerase activity and FK506 binding protein expression following neuroprotection by FK506 in the ischemic rat brain
    S Brecht
    Institute of Pharmacology, University Hospital of Schleswig Holstein, Campus Kiel, Hospitalstrasse 4, 24105, Kiel, Germany
    Neuroscience 120:1037-48. 2003
    ..However, changes of FKBP enzymatic activity result in suppression of the stress cell body response in the peri-infarct area as observed by suppression of c-Jun phosphorylation and Fas-L expression...
  24. doi FKBP family proteins: immunophilins with versatile biological functions
    Cong Bao Kang
    School of Biological Science, Nanyang Technological University, Singapore, Singapore
    Neurosignals 16:318-25. 2008
    ..of two major immunophilins and most of FKBP family members bind FK506 and show peptidylprolyl cis/trans isomerase (PPIase) activity...
  25. ncbi The 28.3 kDa FK506 binding protein from a thermophilic archaeum, Methanobacterium thermoautotrophicum, protects the denaturation of proteins in vitro
    A Ideno
    Marine Biotechnology Institute Co, Ltd, Kamaishi, Iwate, Japan Sekisui Chemical Co, Ltd, Minase Research Institute, Osaka, Japan
    Eur J Biochem 267:3139-49. 2000
    Two families of FK506 binding protein (FKBP) type peptidyl-prolyl cis-trans isomerase (PPIase) have been found in Archaea. One is the 16-18 kDa short type FKBP family, and another is the 26-30 kDa long type FKBP family...
  26. pmc FK506-binding protein of the hyperthermophilic archaeum, Thermococcus sp. KS-1, a cold-shock-inducible peptidyl-prolyl cis-trans isomerase with activities to trap and refold denatured proteins
    A Ideno
    Marine Biotechnology Institute Co Ltd, 3 75 1 Heita, Kamaishi, Iwate 026 0001, Japan
    Biochem J 357:465-71. 2001
    The FK506 (tacrolimus)-binding protein (FKBP) type peptidyl-prolyl cis-trans isomerase (PPIase) in the hyperthermophilic archaeum Thermococcus sp...
  27. pmc FK 506-binding protein proline rotamase is a target for the immunosuppressive agent FK 506 in Saccharomyces cerevisiae
    J Heitman
    Department of Biochemistry, University of Basel, Switzerland
    Proc Natl Acad Sci U S A 88:1948-52. 1991
    ..In vitro, FK 506 binds and inhibits the activity of FK 506-binding protein (FKBP), a peptidylprolyl rotamase (cis-trans isomerase). Cyclosporin A acts similarly on a different proline rotamase, cyclophilin...
  28. ncbi Isolation and amino acid sequence of a new 22-kDa FKBP-like peptidyl-prolyl cis/trans-isomerase of Escherichia coli. Similarity to Mip-like proteins of pathogenic bacteria
    J U Rahfeld
    Max Planck Gesellschaft, Arbeitsgruppe Enzymologie der Peptidbindung, Kurt Mothes Strasse 3, D 06120 Halle Saale, Germany
    J Biol Chem 271:22130-8. 1996
    We identified a periplasmic peptidyl-prolyl cis/trans-isomerase (PPIase) of the (FK506-binding protein (FKBP) type in Escherichia coli (FK506 represents a natural peptidomacrolide containing an acylated pipecolic acid residue)...
  29. doi SUMO-conjugating enzyme (Sce) and FK506-binding protein (FKBP) encoding rice (Oryza sativa L.) genes: genome-wide analysis, expression studies and evidence for their involvement in abiotic stress response
    Neha Nigam
    Department of Plant Molecular Biology, University of Delhi South Campus, Benito Juarez Road, New Delhi, 110021, India
    Mol Genet Genomics 279:371-83. 2008
    ..of two major stress proteins namely SUMO-conjugating enzyme (Sce) and peptidyl prolyl cis-trans isomerase (PPIase) in rice (Oryza sativa L.)...
  30. doi Engineering of monomeric FK506-binding protein 22 with peptidyl prolyl cis-trans isomerase. Importance of a V-shaped dimeric structure for binding to protein substrate
    Cahyo Budiman
    Department of Material and Life Science, Graduate School of Engineering, Osaka University, Yamadaoka, Suita, Osaka, Japan
    FEBS J 276:4091-101. 2009
    ..SIB1 is a homodimeric protein with peptidyl prolyl cis-trans isomerase (PPIase) (EC 5.2.1.8) activity. Each monomer consists of 205 amino acid residues...
  31. ncbi NMR solution structure and dynamics of the peptidyl-prolyl cis-trans isomerase domain of the trigger factor from Mycoplasma genitalium compared to FK506-binding protein
    Martin Vogtherr
    Institut für Organische Chemie der Universität Frankfurt, Marie Curie Str 11, 60439 Frankfurt, Germany
    J Mol Biol 318:1097-115. 2002
    We have solved the solution structure of the peptidyl-prolyl cis-trans isomerase (PPIase) domain of the trigger factor from Mycoplasma genitalium by homo- and heteronuclear NMR spectroscopy...
  32. ncbi The Escherichia coli FKBP-type PPIase SlyD is required for the stabilization of the E lysis protein of bacteriophage phi X174
    Thomas G Bernhardt
    Department of Biochemistry and Biophysics, Texas A and M University, 77843 2128, USA
    Mol Microbiol 45:99-108. 2002
    ..The slyD gene encodes a FKBP-type peptidyl-prolyl cis-trans isomerase (PPIase)...
  33. ncbi Structural and functional studies of FkpA from Escherichia coli, a cis/trans peptidyl-prolyl isomerase with chaperone activity
    F A Saul
    Unité d Immunologie Structurale C N R S U R A 2185, Institut Pasteur, 25 rue du Dr Roux, 75724 Paris Cedex 15, France
    J Mol Biol 335:595-608. 2004
    The protein FkpA from the periplasm of Escherichia coli exhibits both cis/trans peptidyl-prolyl isomerase (PPIase) and chaperone activities...
  34. pmc Hypoxia induces intracellular Ca2+ release by causing reactive oxygen species-mediated dissociation of FK506-binding protein 12.6 from ryanodine receptor 2 in pulmonary artery myocytes
    Bo Liao
    Center for Cardiovascular Sciences, Albany Medical College, Albany, New York, USA
    Antioxid Redox Signal 14:37-47. 2011
    ..6 removal enhanced, whereas RyR2 gene deletion blocked the hypoxic increase in [Ca(2+)](i) in PASMCs. Collectively, we conclude that hypoxia may induce Ca(2+) release by causing ROS-mediated dissociation of FKBP12.6 from RyR2 in PASMCs...
  35. pmc Rapamycin sensitivity in Saccharomyces cerevisiae is mediated by a peptidyl-prolyl cis-trans isomerase related to human FK506-binding protein
    Y Koltin
    Department of Biomolecular Discovery, SmithKline Beecham Pharmaceuticals, King of Prussia, Pennsylvania 19406
    Mol Cell Biol 11:1718-23. 1991
    ..and shown to be distinct members of a class of enzymes that possess peptidyl-prolyl cis-trans isomerase (PPIase) activity...
  36. ncbi Ryanodine receptor mutations associated with stress-induced ventricular tachycardia mediate increased calcium release in stimulated cardiomyocytes
    Christopher H George
    Wales Heart Research Institute, University of Wales College of Medicine, Heath Park, Cardiff, UK
    Circ Res 93:531-40. 2003
    ..Furthermore, equivalent interaction between mutant and WT hRyR2 and FKBP12.6 was demonstrated...
  37. doi Crystal structure of the three FK506 binding protein domains of wheat FKBP73: evidence for a unique wFK73_2 domain
    Tamar Unger
    Department of Structural Biology, Weizmann Institute of Science, 76100, Rehovot, Israel
    J Struct Funct Genomics 11:113-23. 2010
    ..The wFK73_1 domain is responsible for binding FK506 and for peptidyl prolyl cis/trans isomerase (PPIase) activity, while the wFK73_2 and wFK73_3 domains lack these activities...
  38. ncbi Peptide binding induces large scale changes in inter-domain mobility in human Pin1
    Doris M Jacobs
    Institut für Organische Chemie und Chemische Biologie, Johann Wolfgang Goethe Universitat Frankfurt, Marie Curie Strasse 11, 60439 Frankfurt, Germany
    J Biol Chem 278:26174-82. 2003
    Pin1 is a peptidyl-prolyl cis/trans isomerase (PPIase) essential for cell cycle regulation...
  39. ncbi A nuclear FK506-binding protein is a histone chaperone regulating rDNA silencing
    Takashi Kuzuhara
    Laboratory of Developmental Biology, Institute of Molecular and Cellular Biosciences, The University of Tokyo, 1 1 1 Yayoi, Bunkyo ku, Tokyo, 113 0032, Japan
    Nat Struct Mol Biol 11:275-83. 2004
    ..It is a member of the peptidyl prolyl cis-trans isomerase (PPIase) family, whose members were originally identified as enzymes that assist in the proper folding of polypeptides...
  40. pmc RYR2 proteins contribute to the formation of Ca(2+) sparks in smooth muscle
    Guangju Ji
    Department of Biomedical Sciences, Cornell University, Ithaca, NY 14853 6401, USA
    J Gen Physiol 123:377-86. 2004
    ....
  41. ncbi FK506 binding protein 12/12.6 depletion increases endothelial nitric oxide synthase threonine 495 phosphorylation and blood pressure
    Cheng Long
    Department of Molecular Physiology and Biophysics, Baylor College of Medicine, Houston, Tex 77030, USA
    Hypertension 49:569-76. 2007
    ..This molecular mechanism may, in part, explain rapamycin-induced hypertension...
  42. pmc Requirements for peptidyl-prolyl isomerization activity: a comprehensive mutational analysis of the substrate-binding cavity of FK506-binding protein 12
    Teikichi Ikura
    Laboratory of Structural Biology, School of Biomedical Science, Tokyo Medical and Dental University, Tokyo 113 8510, Japan
    Protein Sci 16:2618-25. 2007
    Peptidyl-prolyl isomerase (PPIase) activity is exhibited by many proteins belonging to the PPIase family. However, the catalytic mechanism of this activity remains to be completely elucidated...
  43. ncbi Arrhythmogenesis in catecholaminergic polymorphic ventricular tachycardia: insights from a RyR2 R4496C knock-in mouse model
    Nian Liu
    Molecular Cardiology, IRCCS Fondazione Salvatore Maugeri, Pavia, Italy
    Circ Res 99:292-8. 2006
    ..6 interaction in RyR2(R4496C+/-) is identical to that of WT both before and after epinephrine and caffeine, thus suggesting that it is unlikely that the R4496C mutation interferes with the RyR2/FKBP12.6 complex...
  44. pmc Intracellular calcium leak due to FKBP12.6 deficiency in mice facilitates the inducibility of atrial fibrillation
    Subeena Sood
    Department of Molecular Physiology and Biophysics, Houston, Texas 77030, USA
    Heart Rhythm 5:1047-54. 2008
    ..Studies in patients with AF revealed that impaired diastolic closure of sarcoplasmic reticulum (SR) Ca(2+)-release channels (ryanodine receptors, RyR2) is associated with reduced levels of the RyR2-inhibitory subunit FKBP12.6...
  45. ncbi Catecholaminergic polymorphic ventricular tachycardia: recent mechanistic insights
    Kimmo Kontula
    Department of Medicine, University of Helsinki, 00290 Helsinki, Finland
    Cardiovasc Res 67:379-87. 2005
    ....
  46. ncbi The three-dimensional structure of two redox states of cyclophilin A from Schistosoma mansoni. Evidence for redox regulation of peptidyl-prolyl cis-trans isomerase activity
    Louise J Gourlay
    Istituto Pasteur Fondazione Cenci Bolognetti, Department of Biochemical Sciences A Rossi Fanelli, Sapienza University of Rome, Piazzale Aldo Moro 5, 00185 Rome, Italy
    J Biol Chem 282:24851-7. 2007
    ....
  47. ncbi Defective cardiac ryanodine receptor regulation during atrial fibrillation
    John A Vest
    Department of Physiology and Cellular Biophysics, Clyde and Helen Wu Center for Molecular Cardiology, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
    Circulation 111:2025-32. 2005
    ..6) causes SR Ca2+ leak in failing hearts and can trigger fatal ventricular arrhythmias. Little is known about the role of RyR2 dysfunction in AF, however...
  48. ncbi Mip protein of Legionella pneumophila exhibits peptidyl-prolyl-cis/trans isomerase (PPlase) activity
    G Fischer
    Max Planck Gesellschaft, Arbeitsgruppe Enzymologie der Peptidbindung, Halle, Germany
    Mol Microbiol 6:1375-83. 1992
    ..FKBPs are able to bind to the immunosuppressant macrolide FK506 and possess peptidyl-prolyl cis/trans isomerase (PPIase) activity. The gene coding for the Mip protein was cloned from the chromosome of L...
  49. pmc Identification of cyclophilin as a proinflammatory secretory product of lipopolysaccharide-activated macrophages
    B Sherry
    Laboratory of Medical Biochemistry, Rockefeller University, New York, NY 10021
    Proc Natl Acad Sci U S A 89:3511-5. 1992
    ....
  50. pmc Cloning, expression, and purification of human cyclophilin in Escherichia coli and assessment of the catalytic role of cysteines by site-directed mutagenesis
    J Liu
    Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115
    Proc Natl Acad Sci U S A 87:2304-8. 1990
    ..fluorescence enhancement and for inhibition (IC50 = 19 nM) of cyclophilin's peptidyl-prolyl cis-trans isomerase (rotamase) activity...
  51. ncbi Molecular and biochemical characterization of a Plasmodium falciparum cyclophilin containing a cleavable signal sequence
    J Hirtzlin
    Department of Structural Biology, Biozentrum, University of Basel, Switzerland
    Eur J Biochem 232:765-72. 1995
    ..immunosuppressive effect in T lymphocytes by binding to cyclophilin (CyP), a peptidylprolyl cis-trans isomerase (PPIase)...
  52. ncbi Complexes between porin, hexokinase, mitochondrial creatine kinase and adenylate translocator display properties of the permeability transition pore. Implication for regulation of permeability transition by the kinases
    G Beutner
    Faculty of Biology, University of Konstanz, Germany
    Biochim Biophys Acta 1368:7-18. 1998
    ..The inhibitory effect of N-methylVal-4-cyclosporin on the creatine kinase complex may be explained by direct interaction with the creatine kinase dimer that appeared to support octamer formation...
  53. ncbi Selective inactivation of parvulin-like peptidyl-prolyl cis/trans isomerases by juglone
    L Hennig
    Max Planck Research Unit, Enzymology of Protein Folding, Halle Saale, Germany
    Biochemistry 37:5953-60. 1998
    ..Thus, partial unfolding of the active site of the parvulins was thought to be the cause of the deterioration of PPIase activity.
  54. pmc The Ess1 prolyl isomerase is linked to chromatin remodeling complexes and the general transcription machinery
    X Wu
    Molecular Genetics Program, Wadsworth Center, New York State Department of Health, and Department of Biomedical Sciences, School of Public Health, State University of New York, Albany, NY 12208, USA
    EMBO J 19:3727-38. 2000
    The Ess1/Pin1 peptidyl-prolyl isomerase (PPIase) is thought to control mitosis by binding to cell cycle regulatory proteins and altering their activity...
  55. ncbi Expression of long- and short-type FK506 binding proteins in hyperthermophilic archaea
    Akira Ideno
    Marine Biotechnology Institute, 3 75 1 Heita, Kamaishi, Iwate 026 0001, Japan
    Gene 292:57-63. 2002
    ..clarify the difference between their roles in archaeal cells, they were expressed in Escherichia coli, and their PPIase and chaperone-like protein-folding activities were investigated...
  56. ncbi 21-kDa polypeptide, a low-molecular-weight cyclophilin, is released from pollen of higher plants into the extracellular medium in vitro
    Etsuo Yokota
    Department of Life Science, Graduate School of Science, Himeji Institute of Technology, Harima Science Park City, 678 1297 Hyogo, Japan
    Planta 218:1008-18. 2004
    ..From these results, we concluded that the 21-kDa polypeptide is a low-molecular-weight CyP. The present study showed that CyP in the pollen of higher plants is released into the extracellular matrix under unfavorable conditions...
  57. pmc Ryanodine receptor regulation by intramolecular interaction between cytoplasmic and transmembrane domains
    Christopher H George
    Wales Heart Research Institute, Department of Cardiology, University of Wales College of Medicine, Cardiff, United Kingdom CF14 4XN
    Mol Biol Cell 15:2627-38. 2004
    ..These results provide compelling evidence that specific interaction between cytoplasmic and transmembrane domains is an important mechanism in the intrinsic modulation of RyR Ca(2+) release channels...
  58. pmc The Arabidopsis cyclophilin gene family
    Patrick G N Romano
    Robert Hill Institute, Department of Molecular Biology and Biotechnology, University of Sheffield, Western Bank, Sheffield S10 2TN, United Kingdom
    Plant Physiol 134:1268-82. 2004
    ..As well as fulfilling the basic role of protein folding, they may also play important roles in mRNA processing, protein degradation, and signal transduction and thus may be crucial during both development and stress responsiveness...
  59. ncbi A note on clustering the functionally-related paralogues and orthologues of proteins: a case of the FK506-binding proteins (FKBPs)
    Andrzej Galat
    Departement d Ingenierie et d Etudes des Proteines, Bat 152, DSV CEA, CE Saclay, F 91191 Gif sur Yvette Cedex, France
    Comput Biol Chem 28:129-40. 2004
    ..1 degrees apparent conservation of the crucial amino acid (AA) residues for peptidylprolyl cis/trans isomerase (PPIase) acitity and binding of some immunosuppressive drugs; 2 degrees convergence of the three mentioned above ..
  60. ncbi FK506-binding proteins 51 and 52 differentially regulate dynein interaction and nuclear translocation of the glucocorticoid receptor in mammalian cells
    Gabriela M Wochnik
    Max Planck Institute of Psychiatry, Kraepelinstrasse 10, D 80804 Munich, Germany
    J Biol Chem 280:4609-16. 2005
    ..receptor signaling in mammalian cells: hsp90 interaction, dynein association, and peptidylprolyl isomerase (PPIase) enzyme activity...
  61. ncbi Polo-like kinase 1-mediated phosphorylation stabilizes Pin1 by inhibiting its ubiquitination in human cells
    Frank Eckerdt
    Department of Gynecology and Obstetrics, J W Goethe University, Theodor Stern Kai 7, Frankfurt D 60590, Germany
    J Biol Chem 280:36575-83. 2005
    ..Since previous reports suggested that Plk1 is a substrate of Pin1, our work adds a new dimension to this interaction of two important mitotic regulators...
  62. pmc Gene expression profiling identifies FKBP39 as an inhibitor of autophagy in larval Drosophila fat body
    G Juhasz
    Department of General Zoology, Eotvos Lorand University, Budapest, Hungary
    Cell Death Differ 14:1181-90. 2007
    ..Accordingly, we found that Foxo mutants cannot properly undergo autophagy in response to starvation, and that overexpression of Foxo induces autophagy...
  63. ncbi On the benefit of bivalency in peptide ligand/pin1 interactions
    Sebastian Daum
    Max Planck Research Unit for Enzymology of Protein Folding, Weinbergweg 22, 06120 Halle Saale, Germany
    J Mol Biol 374:147-61. 2007
    The human peptidyl prolyl cis/trans isomerase (PPIase) Pin1 has a key role in developmental processes and cell proliferation...
  64. ncbi Ryanodine receptor: a novel therapeutic target in heart disease
    Rikuo Ochi
    Department of Physiology, New York Medical College, Valhalla, NY 10595, USA
    Recent Pat Cardiovasc Drug Discov 2:110-8. 2007
    ....
  65. pmc Requirements for surface expression and function of adhesin P1 from Streptococcus mutans
    Paula J Crowley
    Department of Oral Biology, University of Florida, Gainesville, FL 32610, USA
    Infect Immun 76:2456-68. 2008
    ..It does not achieve a fully functional form in the absence of the trigger factor PPIase homolog RopA, and its translocation is delayed when DnaK levels are limited...
  66. doi Conditional FKBP12.6 overexpression in mouse cardiac myocytes prevents triggered ventricular tachycardia through specific alterations in excitation-contraction coupling
    Barnabas Gellen
    INSERM, U698, Paris, France
    Circulation 117:1778-86. 2008
    ..6 from RyR2, leading to diastolic sarcoplasmic reticulum Ca(2+) leakage and ventricular tachycardia (VT). We tested the hypothesis that FKBP12.6 overexpression in cardiac myocytes can reduce susceptibility to VT in stress conditions...
  67. doi Cardioprotective effects of hydroxysafflor yellow A on diabetic cardiac insufficiency attributed to up-regulation of the expression of intracellular calcium handling proteins of sarcoplasmic reticulum in rats
    Haibo He
    Institute of Chinese Herbal Medicine, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, China
    Phytother Res 22:1107-14. 2008
    ....
  68. doi Separation/enrichment of active natural low content protein using protein imprinted polymer
    Ruifang Han
    Biochemical Section of Key Laboratory of Functional Polymer Materials, The Ministry of Education of China, Institute of Polymer Chemistry, Chemical School of Nankai University, Tianjin, PR China
    J Chromatogr B Analyt Technol Biomed Life Sci 873:113-8. 2008
    ..The assay of peptidyl-prolyl cis-trans-isomerase (PPIase) activity showed that natural pCyP18 is more active than cloned pCyP18 and, in particular, it is much more ..
  69. doi Involvement of cyclophilin D in mitochondrial permeability transition induction in intact cells
    Hidejiro Tazawa
    Division of Biotechnology and Life Science, Institute of Symbiotic Science and Technology, Tokyo University of Agriculture and Technology, Nakacho 2 24 16, Koganei, Tokyo, Japan
    Arch Biochem Biophys 481:59-64. 2009
    ..The present study aimed to clarify the involvement of cyclophilin D, a peptidyl prolyl cis-trans isomerase (PPIase), in MPT induction in intact cells...
  70. ncbi A new method for purification of functional recombinant GST-cyclophilin A protein from E. coli
    Seonmin Lee
    Department of Biochemistry and Molecular Biology, Medical Science and Engineering Research Center for Bioreaction to Reactive Oxygen Species and Biomedical Science Institute BK 21, School of Medicine, Kyung Hee University, Seoul 130 701, Korea
    Indian J Biochem Biophys 45:374-8. 2008
    ..A (CypA) fusion protein was obtained, without affecting the structural and functional characteristics such as PPIase and chaperone activities...
  71. doi Essential role of Pro 74 in stefin B amyloid-fibril formation: dual action of cyclophilin A on the process
    Aida Smajlović
    Department of Biochemistry, Farmaceutical Faculty, University of Tuzla, Tuzla, Bosnia and Herzegovina
    FEBS Lett 583:1114-20. 2009
    ..These results demonstrate that peptidyl prolyl cis/trans isomerism is rate-limiting in stefin B fibril formation...
  72. doi Application of SAIL phenylalanine and tyrosine with alternative isotope-labeling patterns for protein structure determination
    Mitsuhiro Takeda
    Structural Biology Research Center, Nagoya University, Furo cho, Chikusa ku, Japan
    J Biomol NMR 46:45-9. 2010
    ..2 kDa protein, Escherichia coli peptidyl-prolyl cis-trans isomerase b (EPPIb), and concluded that the combined use of zeta-SAIL Phe and epsilon-SAIL Tyr would be practically the best choice for protein structural determinations...
  73. doi Peptidyl-prolyl isomerase activity in chloroplast thylakoid lumen is a dispensable function of immunophilins in Arabidopsis thaliana
    Björn Ingelsson
    Department of Clinical and Experimental Medicine, Linkoping University, SE 581 85 Linkoping, Sweden
    Plant Cell Physiol 50:1801-14. 2009
    ..folding catalysts, although only two of them, AtFKBP13 and AtCYP20-2, possess peptidyl-prolyl cis/trans isomerase (PPIase) activity...
  74. pmc The Hsp90 cochaperone, FKBP51, increases Tau stability and polymerizes microtubules
    Umesh K Jinwal
    Johnnie B Byrd Sr Alzheimer s Research Institute and Department of Molecular Medicine, University of South Florida, Tampa, Florida 33613, USA
    J Neurosci 30:591-9. 2010
    ..which possesses both an Hsp90-interacting tetratricopeptide domain and a peptidyl-prolyl cis-trans isomerase (PPIase) domain, prevents tau clearance and regulates its phosphorylation status...
  75. doi Ca(2+) release induced by cADP-ribose is mediated by FKBP12.6 proteins in mouse bladder smooth muscle
    Ji Zheng
    Urological Surgery Research Institute, Southwest Hospital, Third Military Medical University, Chongqing, China
    Cell Calcium 47:449-57. 2010
    ..6. Finally, cADPR altered SR Ca(2+) load in WT myocytes but not in FKBP12.6-null myocytes. Taken together, these results suggest that Ca(2+) release induced by cADPR is mediated by FKBP12.6 proteins in mouse bladder smooth muscle...
  76. pmc Intrinsically disordered regions may lower the hydration free energy in proteins: a case study of nudix hydrolase in the bacterium Deinococcus radiodurans
    Omar Awile
    Mediterranean Institute for Life Sciences, Split, Croatia
    PLoS Comput Biol 6:e1000854. 2010
    ..this group includes a number of housekeeping and repair proteins such as DNA polymerase III, nudix hydrolase and rotamase. Here, we focus on a member of the nudix hydrolase family from D...
  77. pmc Altered expression and function of ryanodine receptors and FKBP12.6 after subarachnoid hemorrhage: more than meets the eye
    William F Jackson
    Department of Pharmacology and Toxicology, Michigan State University, East Lansing, Michigan 48824, USA
    J Cereb Blood Flow Metab 31:1-2. 2011
    ..In addition, the mechanisms responsible for the measured changes in expression of ryanodine receptors and FKBP12.6 yet remain unknown. These topics should prove to be fertile ground for future studies...
  78. pmc A Burkholderia pseudomallei macrophage infectivity potentiator-like protein has rapamycin-inhibitable peptidylprolyl isomerase activity and pleiotropic effects on virulence
    Isobel H Norville
    Defence Science and Technology Laboratory, Porton Down SP4 0JQ, UK
    Infect Immun 79:4299-307. 2011
    ..of the FK506-binding protein (FKBP) family, whose members typically exhibit peptidylprolyl cis-trans isomerase (PPIase) activity which is inhibitable by the immunosuppressants FK506 and rapamycin...
  79. pmc Mitogen-activated protein kinase extracellular signal-regulated kinase 2 phosphorylates and promotes Pin1 protein-dependent promyelocytic leukemia protein turnover
    Jun Hee Lim
    Department of Biochemistry, School of Medicine, Case Western Reserve University, Cleveland, Ohio 44106 4935, USA
    J Biol Chem 286:44403-11. 2011
    ..Taken together, our results support a model in which Pin1 promotes PML degradation in an ERK2-dependent manner...
  80. doi Differential expression of genes involved in alternative glycolytic pathways, phosphorus scavenging and recycling in response to aluminum and phosphorus interactions in Citrus roots
    Lin Tong Yang
    College of Resources and Environmental Sciences, Fujian Agriculture and Forestry University, 350002, Fuzhou, China
    Mol Biol Rep 39:6353-66. 2012
    ..PPi-PFK), tonoplast adenosine-triphosphatase subunit A (V-ATPase A), tonoplast pyrophosphatase (V-PPiase), pyruvate kinase (PK), acid phosphatase (APase), phosphoenolpyruvate carboxylase (PEPC), malic enzyme (ME) and ..
  81. doi Cardiac FKBP12.6 overexpression protects against triggered ventricular tachycardia in pressure overloaded mouse hearts
    Laurent Vinet
    Universite Paris Diderot, Sorbonne Paris Cité and Inserm UMR_S 698, 46, rue Henri Huchard, 75877, Paris Cedex 18, France
    Basic Res Cardiol 107:246. 2012
    ....
  82. pmc Involvement of peptidylprolyl cis/trans isomerases in Enterococcus faecalis virulence
    Fany Reffuveille
    USC INRA 2017, Microbiologie de l Environnement, EA956, Universite de Caen, Caen, France
    Infect Immun 80:1728-35. 2012
    ..faecalis stress response or virulence. The other two PPIases, the parvulin family rotamase EF0685 and the cyclophilin family member EF1534, are expected to be surface-exposed proteins...
  83. doi Biochemical characterization of two Azotobacter vinelandii FKBPs and analysis of their interaction with the small subunit of carbamoyl phosphate synthetase
    Maria Dimou
    Department of Agricultural Biotechnology, Agricultural University of Athens, Iera Odos 75, Votanikos, 11855 Athens, Greece
    Mol Biol Rep 39:10003-12. 2012
    ..AvfkbA1 and AvfkbA2, from the soil nitrogen-fixing bacterium Azotobacter vinelandii and show that both possess PPIase activity while AvfkbA2 possesses chaperone activity as well...
  84. pmc Elucidating role of salivary proteins in denture stomatitis using a proteomic approach
    Sompop Bencharit
    Department of Prosthodontics, School of Dentistry, University of North Carolina, CB 7450, Chapel Hill, NC 27599, USA
    Mol Biosyst 8:3216-23. 2012
    ..Further examination in larger populations of these proteins may help to gain a better understanding of DS pathological processes and improve DS treatments...
  85. doi Overexpression of the prolyl isomerase PIN1 promotes cell growth in osteosarcoma cells
    Lu Zhou
    Department of Orthopaedic Surgery, Chonbuk National University Medical School, Jeonju, Jeonbuk 561 756, Republic of Korea
    Oncol Rep 29:193-8. 2013
    PIN1 was recently identified as a peptidyl-prolyl cis-trans isomerase (PPIase). It binds to and isomerizes specific pSer/Thr-Pro motifs and catalytically induces conformational changes after phosphorylation...
  86. doi Depressed calcium-handling proteins due to endoplasmic reticulum stress and apoptosis in the diabetic heart are attenuated by argirein
    F H Shi
    Research Division of Pharmacology, China Pharmaceutical University, 24 Tongjia Lane, Nanjing, 210009, China
    Naunyn Schmiedebergs Arch Pharmacol 386:521-31. 2013
    ..AR has potential in managing DC through attenuating depressed calcium-handling proteins, activated ER stress, and apoptosis in the myocardium...
  87. pmc Dietary vitamin D deficiency in rats from middle to old age leads to elevated tyrosine nitration and proteomics changes in levels of key proteins in brain: implications for low vitamin D-dependent age-related cognitive decline
    Jeriel T R Keeney
    Department of Chemistry, Center of Membrane Sciences, Sanders Brown Center on Aging, University of Kentucky, Lexington, KY 40506, USA
    Free Radic Biol Med 65:324-34. 2013
    ..Together, these results suggest that dietary VitD deficiency contributes to significant nitrosative stress in brain and may promote cognitive decline in middle-aged and elderly adults...
  88. doi FK506-binding protein 12 ligands: a patent review
    Fei Liu
    Nanjing Medical University, The First Affiliated Hospital, Research Division of Clinical Pharmacology, 300 Guangzhou Road, Nanjing, Jiangsu Province, 210029, China
    Expert Opin Ther Pat 23:1435-49. 2013
    FK506-binding protein 12 (FKBP12) is an endogenous protein with peptidyl-prolyl isomerase (PPIase) activity...
  89. ncbi C-terminal 13-residue truncation induces compact trigger factor conformation and severely impairs its dimerization ability
    Yi Shi
    Shanghai Advanced Research Institute, Chinese Academy of Sciences, No 99, Haike Road, Zhangjiang Hi Tech Park, Pudong, Shanghai, 201210, China
    Protein Pept Lett 21:476-82. 2014
    ..TF consists of an N-terminal ribosome binding domain, a middle peptidyl-prolyl cis/trans isomerase (PPIase) domain and a C-terminal domain involved in substrate binding and dimerization...
  90. pmc Implication of PMLIV in both intrinsic and innate immunity
    Faten El Asmi
    INSERM UMR S 1124, Paris, France Université Paris Descartes, Paris, France
    PLoS Pathog 10:e1003975. 2014
    ....
  91. pmc Skp1-Cullin-F-box (SCF)-type ubiquitin ligase FBXW7 negatively regulates spermatogonial stem cell self-renewal
    Mito Kanatsu-Shinohara
    Department of Molecular Genetics, Graduate School of Medicine, Kyoto University, Kyoto 606 8501, Japan Precursory Research for Embryonic Science and Technology PRESTO and
    Proc Natl Acad Sci U S A 111:8826-31. 2014
    ..These results suggest that FBXW7 regulates SSC self-renewal in a negative manner by degradation of MYC. ..
  92. doi Bcl-2 and FKBP12 bind to IP3 and ryanodine receptors at overlapping sites: the complexity of protein-protein interactions for channel regulation
    Tim Vervliet
    KU Leuven, Laboratory of Molecular and Cellular Signaling, Department of Cellular and Molecular Medicine, Campus Gasthuisberg O N 1, Bus 802, B 3000 Leuven, Belgium
    Biochem Soc Trans 43:396-404. 2015
    ....
  93. pmc Oxidation of ryanodine receptor (RyR) and calmodulin enhance Ca release and pathologically alter, RyR structure and calmodulin affinity
    Tetsuro Oda
    Department of Pharmacology University of California, Davis, CA, USA Department of Medicine and Clinical Science, Division of Cardiology, Yamaguchi University Graduate School of Medicine, Ube, Yamaguchi, Japan
    J Mol Cell Cardiol 85:240-8. 2015
    ..6-RyR2 affinity, and causes domain unzipping. Dantrolene can correct domain unzipping, restore CaM-RyR2 affinity, and quiet pathological RyR2 channel gating. F-DPc10 and CaM are useful biosensors of a pathophysiological RyR2 state. ..
  94. pmc Physiological and Molecular Responses to Excess Boron in Citrus macrophylla W
    Mary Rus Martínez-Cuenca
    Department of Citriculture and Vegetal Production, Valencian Institute of Agrarian Research, Moncada, Valencia, Spain
    PLoS ONE 10:e0134372. 2015
    ..3- and 2.4-fold in leaves and roots, respectively. The activity of V-PPiase proton pump, related with the electrochemical gradient in the vacuole, was also enhanced in +B organs...
  95. doi PIN1 genetic polymorphisms and the susceptibility of HBV-related hepatocellular carcinoma in a Guangxi population
    Li Huang
    Department of Clinical Laboratory, First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi Zhuang Autonomous Region, 530021, China
    Tumour Biol 37:6599-606. 2016
    ..03-0.62, p = 0.003). In conclusion, this study's findings suggest that the PIN1 rs2233679 TT genotype, the rs2233682GA genotype, and A alleles might be associated with the HBV-related HCC in a Guangxi study population. ..
  96. doi Inhibition of Aβ(1-40) fibril formation by cyclophilins
    Marten Villmow
    Max Planck Research Unit for Enzymology of Protein Folding, Weinbergweg 22, D 06120 Halle Saale, Germany
    Biochem J 473:1355-68. 2016
    ....
  97. ncbi Conformational dynamics of Peb4 exhibit "mother's arms" chain model: a molecular dynamics study
    Sarath Chandra Dantu
    a Department of Biosciences and Bioengineering, Indian Institute of Technology Bombay, Powai, Mumbai 400076, India
    J Biomol Struct Dyn . 2016
    ..jejuni is an intertwined dimeric, periplasmic holdase, which also exhibits peptidyl prolyl cis/trans isomerase (PPIase) activity...
  98. doi Structural and functional analysis of cyclophilin PpiB mutants supports an in vivo function not limited to prolyl isomerization activity
    Aggeliki Skagia
    Laboratory of General and Agricultural Microbiology, Faculty of Crop Science, Agricultural University of Athens, Iera Odos 75, Votanikos, Athens, 11855, Greece
    Genes Cells 22:32-44. 2017
    Escherichia coli cyclophilin PpiB is a peptidyl-prolyl cis/trans isomerase (PPIase, EC: 5.2.1.8), involved in the negative modulation of various bacterial processes, such as swimming and swarming motility and biofilm formation ability...
  99. doi Overexpression of phytochelatin synthase (pcs) enhances abiotic stress tolerance by altering the proteome of transformed Anabaena sp. PCC 7120
    Neha Chaurasia
    Molecular Biology Section, Laboratory of Algal Biology, Center of Advanced Study in Botany, Institute of Science, Banaras Hindu University, Varanasi, 221005, India
    Protoplasma . 2016
    ..Such recombinant strains have potential for future use as biofertilizer...
  100. ncbi Cyclophilin-A is a zinc-dependent DNA binding protein in macrophages
    U Krummrei
    Institute of Experimental and Clinical Pharmacology and Toxicology, University of Erlangen Nurnberg, Germany
    FEBS Lett 371:47-51. 1995
    ..Peptidyl-prolyl cisltrans isomerase (PPIase) activity of nuclear CypA is inhibited by zinc ions. The zinc inhibited CypA does not bind cyclosporin A (CsA)...
  101. ncbi The CYP2 gene of Saccharomyces cerevisiae encodes a cyclosporin A-sensitive peptidyl-prolyl cis-trans isomerase with an N-terminal signal sequence
    P L Koser
    Department of Molecular Genetics, SmithKline Beecham Pharmaceuticals, King of Prussia, PA 19406
    Gene 108:73-80. 1991
    ..Saccharomyces cerevisiae contain a major cytosolic cyclophilin (Cyp)-related peptidyl-prolyl cis-trans isomerase (PPIase) which is the target for cyclosporin A (CsA) cytotoxicity and which is encoded by the CYP1 gene [Haendler et al...

Research Grants51

  1. ALLOSTERIC SITE STRUCTURES OF CARDIOVASCULAR CHANNELS
    Arthur Karlin; Fiscal Year: 2011
    ..The results will provide insights into the molecular mechanisms of allosteric interactions in these two channels and will provide molecular structural bases for cardiovascular therapeutics targeted at these channels. ..
  2. RAZVAN LIVIU CORNEA; Fiscal Year: 2016
    ..We will conduct fundamental quantitative molecular fluorescence studies that will clarify both structurally and functionally how FKBP binds to and regulates RyR function in the heart. ..
  3. Philip W Landfield; Fiscal Year: 2016
    ..that suggests that downregulation of immunophilins, particularly FK-506 binding protein 1b and/or 1a (FKBP1b/1a), leads to a cascade of RyR destabilization, greater CICR and larger sAHPs...
  4. Chad A Dickey; Fiscal Year: 2016
    ..both an Hsp90 interacting tetratricopeptide (TPR) domain and a cis-trans peptidyl-prolyl cis-trans isomerase (PPIase) domain, was found to prevent tau clearance and regulate its phosphorylation status...
  5. THE ROLE OF PIN1 IN MITOSIS WITH DESIGNED INHIBITORS
    FELICIA ETZKORN; Fiscal Year: 2002
    ..the folding process is accelerated by the peptidyl-prolyl isomerase (PPIase enzymes)...
  6. SUBSTRATES FOR PEPTIDYL PROLYL CIS-TRANS ISOMERASE ASSAY
    Roger Tung; Fiscal Year: 1990
    ....
  7. ANDREW ROBERT MARKS; Fiscal Year: 2016
    ..The proposed studies are significant because they will provide novel insights concerning the mechanisms of HF progression. ..
  8. Lipid electrophile adduction of Pin1 and effects on substrate binding &activity
    Christopher D Aluise; Fiscal Year: 2013
    ..The proposed research allows for significant insight into the cellular response to Pin1 protein modification as a consequence of lipid peroxidation. ..
  9. Regulation of Breast Cancer Growth by MLK-3
    AJAY NMN RANA; Fiscal Year: 2013
    ..Further, our results will point to the possibility of utilizing MLK inhibitor(s) as a novel therapeutic intervention for breast cancer therapy. ..
  10. Yeast Ess1, a Conserved PPlase Essential for Mitosis
    Steven D Hanes; Fiscal Year: 2010
    ..One exception is a PPIase called Ess1, which is essential for growth in the yeast, Saccharomyces cerevisiae...
  11. ADP: A Master Regulator for Bioenergetics and Ca2+/ROS Signaling in Heart
    Shey Shing Sheu; Fiscal Year: 2012
    ..The exploratory and high-risk ideas in this application, if validated, will break new ground in a wide spectrum of disease mechanisms and treatments. ..
  12. Pin1-dependent telomere regulation in aging and Alzheimer's disease
    Tae Ho Lee; Fiscal Year: 2010
    ..This study will have a significant impact upon our basic understanding of AD, and might eventually facilitate the development of novel treatments of AD via targeting of telomere maintenance. ..
  13. Pin1-dependent telomere regulation in aging and Alzheimer's disease
    Tae Ho Lee; Fiscal Year: 2013
    ..These studies should provide novel insight into telomere maintenance during aging and AD, and might have novel implications for developing new therapies. ..
  14. The Importance of Prolyl 3-hydroxylation in recessive Osteogenesis Imperfecta
    ERICA PAIGE HOMAN; Fiscal Year: 2013
    ..In addition to its function as a 3-hydroxylase, CypB functions as a cis/trans isomerase (PPIase)[9]...
  15. NANCY ELIZABETH FREITAG; Fiscal Year: 2016
    ..The ultimate goal of the specific aims will be to elucidate how PrsA2 modulates the secretion and/or activity of virulence factors to promote bacterial pathogenesis in mammalian hosts. ..
  16. Genetic and Molecular Analyses of Protein Biogenesis in the Neuroretina
    Paulo A Ferreira; Fiscal Year: 2013
    ..Aim 3. Test the hypothesis that the cis-trans prolyl isomerase (PPIase) activity in the CY domain of RanBP2 controls the biogenesis of selective proteins that are critical to the ..
  17. TOWARDS RATIONALLY DESIGNED IMMUNOSUPPRESSANTS
    TIMOTHY CURRAN; Fiscal Year: 1992
    ..when it is bound to cyclophilin, a cytoplasmic protein that possesses peptidyl prolyl cis-trans isomerase (rotamase) enzymatic activity...
  18. Cell Repolarization, Alternans, and Arrhythmogenesis
    David S Rosenbaum; Fiscal Year: 2010
    ..These studies are expected to improve understanding of the functional organization of electrical activity in HF, and provide fundamentally novel insights into mechanisms and therapies for SCO. ..
  19. STRUCTURE/FUNCTION OF HIV1 CAPSID/CYCLOPHILIN COMPLEX
    Wesley Sundquist; Fiscal Year: 2001
    ..of Pro90 in CA bound to cyclophilin A suggests that this residue may act as a substrate for cyclophilin rotamase activity...
  20. Post-translation regulation of Listeria monocytogenes virulence factors
    NANCY ELIZABETH FREITAG; Fiscal Year: 2010
    ..monocytogenes-based vaccines for delivery of foreign antigens. ..
  21. Designed Inhibitors of Pin1 in Mitosis
    FELICIA ETZKORN; Fiscal Year: 2009
    ..The unique peptidyl-prolyl isomerase (PPIase) enzymatic activity of Pin1 in the regulation of biological processes is interesting for fundamental reasons...
  22. MINERALIZATION STUDIES RELATED TO ORAL BIOLOGY
    HARRISON ANDERSON; Fiscal Year: 2005
    ..phosphatase (ALP), ATPase, nucleotide triphosphate pyrophosphohydrolase (NTPPase) and inorganic pyrophosphatase (PPiase), in regulating the mineralization of isolated MVs from rat growth plate, and in promoting or inhibiting in vivo ..
  23. COLLAGEN FOLDING IN PRESENCE OF CIS-TRANS ISOMERASE
    Hans Peter Bachinger; Fiscal Year: 1990
    ....
  24. STRUCTURE/FUNCTION ANALYSIS OF MITOTIC REGULATORS
    JOSEPH NOEL; Fiscal Year: 2001
    ..The human peptidyl-prolyl cis-trans isomerase (PPIase) Pin1 is a conserved mitotic regulator essential for the G2 to M transition of the eukaryotic cell cycle...
  25. CATALYZED AMIDE ISOMERIZATION: SYNTHETIC ROTAMASES
    Thomas Lectka; Fiscal Year: 2001
    ..mild, selective catalysts for amide isomerization (AI), culminating in the systematic development of model rotamase enzymes that catalyze the folding of peptides through the cis-trans isomerization of proline residues...
  26. Role of the Prolylisomerase Pin1 in Oncogenesis
    Gerburg Wulf; Fiscal Year: 2007
    ..4) To study the effect of the inhibition of Pin1's PPIase activity as potential cancer therapy in vitro and in vivo...
  27. Pore opening: A target for mitochondrial DNA mutations
    H Zassenhaus; Fiscal Year: 2005
    ..Since such mutations may be an important contributing factor for many adult-onset diseases, these studies may provide insights into novel therapeutic strategies. ..
  28. Mechanisms Regulation Functions of Airway Smooth Muscle
    Reynold Panettieri; Fiscal Year: 2007
    ..Thus, understanding the transcriptional mechanisms regulating the expression of inflammatory genes in ASM will likely lead to new therapeutic approaches for the treatment of asthma. ..
  29. CARDIAC AND SKELETAL MUSCLE CALCIUM RELEASE CHANNELS
    Andrew Marks; Fiscal Year: 2009
    ..Thus, the proposed studies are highly relevant to human diseases including heart failure and cardiac arrhythmias. ..
  30. Heterogeneity of hypoxic Ca2+ release in pulmonary and *
    Yong Xiao Wang; Fiscal Year: 2006
    ..The proposed studies are also of fundamental physiological significance with respect to the regulation of Ca2+ release in other cell types. ..
  31. Regulation of cardiac ion channel function via allosteric modulators
    Andrew Marks; Fiscal Year: 2007
    ..The studies are significant because they may lead to a novel therapeutic approach based on allosteric modulation of RyR that can result in improved therapy for human cardiovascular diseases. ..
  32. Novel Signaling for Ca2+ and Release in Airway Myocytes
    Yong Xiao Wang; Fiscal Year: 2007
    ..6, and/or RyRs are ubiquitously expressed in a variety of cell types, the mechanistic findings from the proposed study will have general biological and pathological significance for various Ca2+-mediated cellular effects. ..
  33. Mechanisms for hypoxic Ca2+ release in pulmonary artery myocytes
    Yong Xiao Wang; Fiscal Year: 2010
    ..The findings from this proposal will enhance our understanding of cellular molecular mechanisms for hypoxic [Ca2+]i rise in PASMCs and associated HPV, and may lead to identify potential novel targets to treat pulmonary hypertension. ..
  34. The Role of PP2A in Yeast Cell Cycle Progression
    Yu Jiang; Fiscal Year: 2009
    ..To test the hypothesis that the Tap42-PP2Ac complex controls the G2 gene expression through the Fkh1/2 transcription factors. This study is part of our long-term goals to understand the role of PP2A in cell growth control. ..
  35. CONTROL OF MICROVASCULAR FUNCTION BY OXYGEN
    William Jackson; Fiscal Year: 2006
    ....
  36. 2007 Vascular Cell Biology Gordon Research Conference
    Bradford Berk; Fiscal Year: 2007
    ..unreadable] [unreadable] [unreadable]..
  37. Mechanisms of RNA virus-host interaction
    Sailen Barik; Fiscal Year: 2009
    ..Together, these results should lead to a better understanding of the replication of RSV in particular and of RNA viruses in general, and pave the way for a more reliable management of the viral diseases. ..
  38. REVERSIBLE PROTEIN PHOSPHORYLATION IN APICOMPLEXANS
    Sailen Barik; Fiscal Year: 2004
    ..These results should form the cornerstone in the detailed elucidation of the regulatory pathways and possible drug-target interactions in Plasmodium in particular, and Apicomplexans in general. ..
  39. CARDIOVASCULAR RESEARCH TRAINING
    Bradford Berk; Fiscal Year: 2004
    ..The University of Rochester is a research-intensive institution with a long tradition and commitment to training investigators which should facilitate the success of this program in cardiovascular research. ..
  40. Interactions between ocular tissue and RSV
    Sailen Barik; Fiscal Year: 2004
    ..be proven, it would establish an animal model for RSV-eye interaction, and open new directions in ocular immunopathology, RNA virus-activated signaling pathways in the eye, and antiviral drug regimen targeting the eye ..
  41. Mechanisms of chemopreventive effect of resveratrol
    Zigang Dong; Fiscal Year: 2009
    ..Our long-term goal is to identify the molecular mechanism explaining the anti-tumor effect exhibited by resveratrol. Such knowledge will help in developing better chemopreventive agents with fewer side effects. ..
  42. Function and Regulation of Pin2/TRF1 and PinX1
    Kun Ping Lu; Fiscal Year: 2005
    ..These studies should yield new insights into telomere maintenance, cell growth control and oncogenesis, and may lead to the development of new anticancer therapy. ..
  43. Study on Ultraviolet-induced Signal Transduction
    Zigang Dong; Fiscal Year: 2010
    ..These preclinical studies are designed to lead to the development of new strategies for the chemoprevention of human skin cancers. ..
  44. Docking Site Mutations in the Fe-and MoFe-proteins.
    Nara Gavini; Fiscal Year: 2002
    ..We believe that these studies will provide new insights regarding how the components of this complex metalloenzyme maintain such high specificity in their interactions. ..
  45. REGULATION OF SARCOPLASMIC RETICULUM CA2+ RELEASE
    Gerhard Meissner; Fiscal Year: 2009
    ..abstract_text> ..
  46. INHIBITION OF CARCINOGENESIS BY TEA AND TEA CONSTITUENTS
    Zigang Dong; Fiscal Year: 2010
    ..abstract_text> ..
  47. Molecular basis of arsenic-induced cell transformation
    Zigang Dong; Fiscal Year: 2007
    ..Such knowledge will facilitate the design of more effective and specific strategies with fewer side effects for chemoprevention of arsenic-induced cancer. ..
  48. Function and Regulation of the Phosphorylation-Specific Prolyl lsomerase Pin 1
    Kun Ping Lu; Fiscal Year: 2010
    ..In lay language, we have identified a new enzyme called Pin1 critical for cancer development and will continue to investigate the function and regulation of Pin1 during cancer development and hope to identify new drug targets. ..
  49. Anticarcinogenic Mechanisms of Tea Constituents
    Zigang Dong; Fiscal Year: 2007
    ....
  50. Prolyl Isomerase Pin 1 and Neurodegeneration
    Kun Ping Lu; Fiscal Year: 2009
    ..These studies should help elucidate the molecular mechanisms of AD and related disorders, and may also have novel implications for their therapies. ..