Genomes and Genes
Gene Symbol: FKBP1B
Description: FK506 binding protein 1B
Alias: FKBP12.6, FKBP1L, OTK4, PKBP1L, PPIase, peptidyl-prolyl cis-trans isomerase FKBP1B, 12.6 kDa FK506-binding protein, 12.6 kDa FKBP, FK506 binding protein 1B, 12.6 kDa, FK506-binding protein 12.6, FKBP-12.6, FKBP-1B, PPIase FKBP1B, calstabin 2, h-FKBP-12, immunophilin FKBP12.6, rotamase
Publications308 found, 100 shown here
- FKBP binding characteristics of cardiac microsomes from diverse vertebratesL H Jeyakumar
Department of Biological Sciences, Vanderbilt University, Nashville, Tennessee 37235, USA
Biochem Biophys Res Commun 281:979-86. 2001..6. Dog is the exception. It can now be concluded that the association of FKBP isoforms with RyR2 is widely conserved in the hearts of different species of vertebrates...
- A cyclophilin-like peptidyl-prolyl cis/trans isomerase from Legionella pneumophila--characterization, molecular cloning and overexpressionB Schmidt
Max Planck Gesellschaft, Arbeitsgruppe Enzymologie der Peptidbindung, Halle Saale, Germany
Mol Microbiol 21:1147-60. 1996..Like human cyclophilin, the L. p. Cyp18 exhibits nuclease activity, but this enzymatic activity does not appear to be linked with the native structure of the protein...
- Mapping the ryanodine receptor FK506-binding protein subunit using fluorescence resonance energy transferRazvan L Cornea
Department of Biochemistry, Molecular Biology, and Biophysics, University of Minnesota, Minneapolis, Minnesota 55455, USA
J Biol Chem 285:19219-26. 2010..FRET mapping of RyR-bound FKBP12.6 is consistent with the predictions of a previous cryoelectron microscopy study and strongly supports the proposed structural model...
- Overexpression of FK506-binding protein FKBP12.6 in cardiomyocytes reduces ryanodine receptor-mediated Ca(2+) leak from the sarcoplasmic reticulum and increases contractilityJ Prestle
Department of Cardiology and Pneumology, Georg August University Goettingen, Goettingen, Germany
Circ Res 88:188-94. 2001..Taken together, these data suggest that FKBP12.6 stabilizes the closed conformation state of RyR2. This may reduce diastolic SR-Ca(2+) leak and consequently increase SR-Ca(2+) release and myocyte shortening...
- The conserved sites for the FK506-binding proteins in ryanodine receptors and inositol 1,4,5-trisphosphate receptors are structurally and functionally differentG Bultynck
Laboratorium voor Fysiologie, K U Leuven Campus Gasthuisberg O N, Herestraat 49, B 3000 Leuven, Belgium
J Biol Chem 276:47715-24. 2001..Structural differences in the FKBP-binding site of RyRs and IP(3)Rs may contribute to the occurrence of a stable interaction between RyR isoforms and FKBPs and to the absence of such interaction with IP(3)Rs...
- Three-dimensional visualization of FKBP12.6 binding to an open conformation of cardiac ryanodine receptorManjuli Rani Sharma
Wadsworth Center, New York State Department of Health, School of Public Health, State University of New York at Albany, Albany, New York 12201 0509, USA
Biophys J 90:164-72. 2006..A thorough understanding of the structural basis of RyR2-FKBP12.6 interaction should aid in understanding the roles that have been proposed for FKBP12.6 in heart failure and in certain forms of sudden cardiac death...
- Archaeal peptidyl prolyl cis-trans isomerases (PPIases) update 2004Tadashi Maruyama
Japan Marine Science and Technology Center, 2 15 Natsushima cho, Yokosuka shi, Kanagawa 237 0061, Japan
Front Biosci 9:1680-720. 2004..This is a cyclosporin A (CsA) sensitive CyP with a molecular weight of 19.4 kDa. The PPIase activity and CsA sensitivity of HbsCyP19 is higher at higher salt concentration in the medium...
- Developmental regulation and coordinate reexpression of FKBP65 with extracellular matrix proteins after lung injury suggest a specialized function for this endoplasmic reticulum immunophilinCharles E Patterson
Department of Cell Biology, University of Texas Southwestern Medical Center, Dallas 75390 9039, USA
Cell Stress Chaperones 10:285-95. 2005..The response to injury, which may be in part a direct response to TGF-beta1, assures the presence of FKBP65 in the ER of cells actively producing components of the extracellular matrix...
- Altered stoichiometry of FKBP12.6 versus ryanodine receptor as a cause of abnormal Ca(2+) leak through ryanodine receptor in heart failureM Yano
Second Department of Internal Medicine, Yamaguchi University School of Medicine, Yamaguchi, Japan
Circulation 102:2131-6. 2000..Here, we report a novel mechanism of cardiac dysfunction revealed by assessing the functional interaction of FK506-binding protein (FKBP12.6) with the cardiac ryanodine receptor (RyR) in a canine model of pacing-induced heart failure...
- Localization of PKA phosphorylation site, Ser(2030), in the three-dimensional structure of cardiac ryanodine receptorPeter P Jones
Department of Physiology and Biophysics, Libin Cardiovascular Institute of Alberta, University of Calgary, Calgary, Alberta, Canada T2N 4N1
Biochem J 410:261-70. 2008..6 binding. On the basis of the three-dimensional localizations of a number of residues or regions, a model for the subunit organization in the structure of RyR2 is proposed...
- Central domain of the human cardiac muscle ryanodine receptor does not mediate interaction with FKBP12.6Spyros Zissimopoulos
Wales Heart Research Institute, Department of Cardiology, Wales College of Medicine, Cardiff University, UK
Cell Biochem Biophys 43:203-19. 2005..Further structural analysis will be necessary to unravel this intricate signaling system and the current model of FKBP12-RyR interaction via a single, central RyR epitope may therefore require revision...
- Archaeal peptidyl prolyl cis-trans isomerases (PPIases)T Maruyama
Marine Biotechnology Institute, Kamaishi Laboratories, 3 75 1 Heita, Kamaishi shi, Iwate 026 0001, Japan
Front Biosci 5:D821-36. 2000..It is a cyclosporin A (CsA) sensitive CyP with a MW of 19.4kDa. The PPIase activity and CsA sensitivity of this CyP is higher at higher salt concentration in the medium...
- Identification of functional FKB protein in Echinococcus granulosus: its involvement in the protoscolicidal action of rapamycin derivates and in calcium homeostasisAndrea C Cumino
Laboratorio de Zoonosis Parasitarias, Departamento de Biologia, Facultad de Ciencias Exactas y Naturales, Universidad Nacional de Mar del Plata UNMdP, Funes 3350, Nivel Cero, 7600 Mar del Plata, Argentina
Int J Parasitol 40:651-61. 2010..These proteins display a peptidyl-prolyl rotamase function that is believed to catalyze protein folding and they are well-validated anti-proliferative drug targets ..
- Dissociation of FKBP12.6 from ryanodine receptor type 2 is regulated by cyclic ADP-ribose but not beta-adrenergic stimulation in mouse cardiomyocytesXu Zhang
National Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, 15 Datun Road, Chaoyang District, Beijing 100101, China
Cardiovasc Res 84:253-62. 2009..6 affects Ca(2+) sparks and mediates the inotropic action of isoproterenol (ISO), and to investigate the underlying mechanisms of cyclic ADP-ribose (cADPR) regulation of Ca(2+) sparks...
- Characterization of high molecular weight FK-506 binding activities reveals a novel FK-506-binding protein as well as a protein complexG Wiederrecht
Department of Immunology Research, Merck Research Laboratories, Rahway, New Jersey 07065
J Biol Chem 267:21753-60. 1992..upon calmodulin (CaM) for formation of the complex and demonstrates that the peptidyl-prolyl cis-trans isomerase (PPIase) activity of FKBP12 is not required for binding of FKBP12...
- A novel FK506- and rapamycin-binding protein (FPR3 gene product) in the yeast Saccharomyces cerevisiae is a proline rotamase localized to the nucleolusB M Benton
Department of Molecular and Cell Biology, University of California, Berkeley 94720 3202
J Cell Biol 127:623-39. 1994The gene (FPR3) encoding a novel type of peptidylpropyl-cis-trans-isomerase (PPIase) was isolated during a search for previously unidentified nuclear proteins in Saccharomyces cerevisiae...
- FKBP-type peptidyl-prolyl cis-trans isomerase from a sulfur-dependent hyperthermophilic archaeon, Thermococcus sp. KS-1T Iida
Marine Biotechnology Institute, Kamaishi Laboratories, 3 75 1 Heita, Kamaishi, Iwate 026 0001, Japan
Gene 222:249-55. 1998A gene encoding an FK506 binding protein (FKBP)-type peptidyl-prolyl cis-trans isomerase (PPIase) was cloned from a hyperthermophilic archaeon, Thermococcus sp. KS-1, and sequenced...
- FK506 binding protein from a thermophilic archaeon, Methanococcus thermolithotrophicus, has chaperone-like activity in vitroM Furutani
Kamaishi Laboratories, Marine Biotechnology Institute Co Ltd, 3 75 1 Heita Kamaishi, Iwate 026 0001, Japan
Biochemistry 39:453-62. 2000..MTFK exhibited FK506 sensitive PPIase (peptidyl prolyl cis-trans isomerase) activity which accelerated the speed of ribonuclease T1 refolding, which is ..
- FK506-binding protein-type peptidyl-prolyl cis-trans isomerase from a halophilic archaeum, Halobacterium cutirubrumT Iida
Marine Biotechnology Institute, Kamaishi Laboratories, 3 75 1 Heita, Kamaishi, 026 0001, Iwate, Japan
Gene 256:319-26. 2000..archaeum, Halobacterium cutirubrum, has been shown to have a cyclophilin-type peptidyl-prolyl cis-trans isomerase (PPIase)...
- Wheat FKBP73 functions in vitro as a molecular chaperone independently of its peptidyl prolyl cis-trans isomerase activityIsaac Kurek
Dep artment of Plant Sciences, Tel Aviv University, Tel Aviv 69978, Israel
Planta 215:119-26. 2002..In vitro studies indicated that wFKBP73 possesses PPIase activity, binds calmodulin and forms a heterocomplex with mammalian p23 and wheat Hsp90 in wheat-germ lysate...
- A kinetically trapped intermediate of FK506 binding protein forms in vitro: chaperone machinery dominates protein folding in vivoMartin A Wear
Institute of Structural and Molecular Biology, Structural Biochemistry Group, The University of Edinburgh, Michael Swann Building, King s Buildings, Mayfield Road, Edinburgh EH9 3JR, UK
Protein Expr Purif 51:80-95. 2007..All three natively purified proteins have, within experimental error, the same peptidyl-prolyl isomerase (PPIase) activity (k(cat)/K(m) approximately 1 x 10(6)M(-1)s(-1)), and bind a natural inhibitor, rapamycin, with the same ..
- A novel role for the immunophilin FKBP52 in copper transportReiko Sanokawa-Akakura
Department of Biochemistry and Molecular Biology, University of Medicine and Dentistry of New Jersey New Jersey Medical School, 185 South Orange Avenue, Newark, NJ 07103, USA
J Biol Chem 279:27845-8. 2004FK506-binding protein 52 (FKBP52) is an immunophilin that possesses peptidylprolyl cis/trans-isomerase (PPIase) activity and is a component of a subclass of steroid hormone receptor complexes...
- Changes in peptidyl-prolyl cis/trans isomerase activity and FK506 binding protein expression following neuroprotection by FK506 in the ischemic rat brainS Brecht
Institute of Pharmacology, University Hospital of Schleswig Holstein, Campus Kiel, Hospitalstrasse 4, 24105, Kiel, Germany
Neuroscience 120:1037-48. 2003..However, changes of FKBP enzymatic activity result in suppression of the stress cell body response in the peri-infarct area as observed by suppression of c-Jun phosphorylation and Fas-L expression...
- FKBP family proteins: immunophilins with versatile biological functionsCong Bao Kang
School of Biological Science, Nanyang Technological University, Singapore, Singapore
Neurosignals 16:318-25. 2008..of two major immunophilins and most of FKBP family members bind FK506 and show peptidylprolyl cis/trans isomerase (PPIase) activity...
- The 28.3 kDa FK506 binding protein from a thermophilic archaeum, Methanobacterium thermoautotrophicum, protects the denaturation of proteins in vitroA Ideno
Marine Biotechnology Institute Co, Ltd, Kamaishi, Iwate, Japan Sekisui Chemical Co, Ltd, Minase Research Institute, Osaka, Japan
Eur J Biochem 267:3139-49. 2000Two families of FK506 binding protein (FKBP) type peptidyl-prolyl cis-trans isomerase (PPIase) have been found in Archaea. One is the 16-18 kDa short type FKBP family, and another is the 26-30 kDa long type FKBP family...
- FK506-binding protein of the hyperthermophilic archaeum, Thermococcus sp. KS-1, a cold-shock-inducible peptidyl-prolyl cis-trans isomerase with activities to trap and refold denatured proteinsA Ideno
Marine Biotechnology Institute Co Ltd, 3 75 1 Heita, Kamaishi, Iwate 026 0001, Japan
Biochem J 357:465-71. 2001The FK506 (tacrolimus)-binding protein (FKBP) type peptidyl-prolyl cis-trans isomerase (PPIase) in the hyperthermophilic archaeum Thermococcus sp...
- FK 506-binding protein proline rotamase is a target for the immunosuppressive agent FK 506 in Saccharomyces cerevisiaeJ Heitman
Department of Biochemistry, University of Basel, Switzerland
Proc Natl Acad Sci U S A 88:1948-52. 1991..In vitro, FK 506 binds and inhibits the activity of FK 506-binding protein (FKBP), a peptidylprolyl rotamase (cis-trans isomerase). Cyclosporin A acts similarly on a different proline rotamase, cyclophilin...
- Isolation and amino acid sequence of a new 22-kDa FKBP-like peptidyl-prolyl cis/trans-isomerase of Escherichia coli. Similarity to Mip-like proteins of pathogenic bacteriaJ U Rahfeld
Max Planck Gesellschaft, Arbeitsgruppe Enzymologie der Peptidbindung, Kurt Mothes Strasse 3, D 06120 Halle Saale, Germany
J Biol Chem 271:22130-8. 1996We identified a periplasmic peptidyl-prolyl cis/trans-isomerase (PPIase) of the (FK506-binding protein (FKBP) type in Escherichia coli (FK506 represents a natural peptidomacrolide containing an acylated pipecolic acid residue)...
- SUMO-conjugating enzyme (Sce) and FK506-binding protein (FKBP) encoding rice (Oryza sativa L.) genes: genome-wide analysis, expression studies and evidence for their involvement in abiotic stress responseNeha Nigam
Department of Plant Molecular Biology, University of Delhi South Campus, Benito Juarez Road, New Delhi, 110021, India
Mol Genet Genomics 279:371-83. 2008..of two major stress proteins namely SUMO-conjugating enzyme (Sce) and peptidyl prolyl cis-trans isomerase (PPIase) in rice (Oryza sativa L.)...
- Engineering of monomeric FK506-binding protein 22 with peptidyl prolyl cis-trans isomerase. Importance of a V-shaped dimeric structure for binding to protein substrateCahyo Budiman
Department of Material and Life Science, Graduate School of Engineering, Osaka University, Yamadaoka, Suita, Osaka, Japan
FEBS J 276:4091-101. 2009..SIB1 is a homodimeric protein with peptidyl prolyl cis-trans isomerase (PPIase) (EC 18.104.22.168) activity. Each monomer consists of 205 amino acid residues...
- NMR solution structure and dynamics of the peptidyl-prolyl cis-trans isomerase domain of the trigger factor from Mycoplasma genitalium compared to FK506-binding proteinMartin Vogtherr
Institut für Organische Chemie der Universität Frankfurt, Marie Curie Str 11, 60439 Frankfurt, Germany
J Mol Biol 318:1097-115. 2002We have solved the solution structure of the peptidyl-prolyl cis-trans isomerase (PPIase) domain of the trigger factor from Mycoplasma genitalium by homo- and heteronuclear NMR spectroscopy...
- The Escherichia coli FKBP-type PPIase SlyD is required for the stabilization of the E lysis protein of bacteriophage phi X174Thomas G Bernhardt
Department of Biochemistry and Biophysics, Texas A and M University, 77843 2128, USA
Mol Microbiol 45:99-108. 2002..The slyD gene encodes a FKBP-type peptidyl-prolyl cis-trans isomerase (PPIase)...
- Structural and functional studies of FkpA from Escherichia coli, a cis/trans peptidyl-prolyl isomerase with chaperone activityF A Saul
Unité d Immunologie Structurale C N R S U R A 2185, Institut Pasteur, 25 rue du Dr Roux, 75724 Paris Cedex 15, France
J Mol Biol 335:595-608. 2004The protein FkpA from the periplasm of Escherichia coli exhibits both cis/trans peptidyl-prolyl isomerase (PPIase) and chaperone activities...
- Hypoxia induces intracellular Ca2+ release by causing reactive oxygen species-mediated dissociation of FK506-binding protein 12.6 from ryanodine receptor 2 in pulmonary artery myocytesBo Liao
Center for Cardiovascular Sciences, Albany Medical College, Albany, New York, USA
Antioxid Redox Signal 14:37-47. 2011..6 removal enhanced, whereas RyR2 gene deletion blocked the hypoxic increase in [Ca(2+)](i) in PASMCs. Collectively, we conclude that hypoxia may induce Ca(2+) release by causing ROS-mediated dissociation of FKBP12.6 from RyR2 in PASMCs...
- Rapamycin sensitivity in Saccharomyces cerevisiae is mediated by a peptidyl-prolyl cis-trans isomerase related to human FK506-binding proteinY Koltin
Department of Biomolecular Discovery, SmithKline Beecham Pharmaceuticals, King of Prussia, Pennsylvania 19406
Mol Cell Biol 11:1718-23. 1991..and shown to be distinct members of a class of enzymes that possess peptidyl-prolyl cis-trans isomerase (PPIase) activity...
- Ryanodine receptor mutations associated with stress-induced ventricular tachycardia mediate increased calcium release in stimulated cardiomyocytesChristopher H George
Wales Heart Research Institute, University of Wales College of Medicine, Heath Park, Cardiff, UK
Circ Res 93:531-40. 2003..Furthermore, equivalent interaction between mutant and WT hRyR2 and FKBP12.6 was demonstrated...
- Crystal structure of the three FK506 binding protein domains of wheat FKBP73: evidence for a unique wFK73_2 domainTamar Unger
Department of Structural Biology, Weizmann Institute of Science, 76100, Rehovot, Israel
J Struct Funct Genomics 11:113-23. 2010..The wFK73_1 domain is responsible for binding FK506 and for peptidyl prolyl cis/trans isomerase (PPIase) activity, while the wFK73_2 and wFK73_3 domains lack these activities...
- Peptide binding induces large scale changes in inter-domain mobility in human Pin1Doris M Jacobs
Institut für Organische Chemie und Chemische Biologie, Johann Wolfgang Goethe Universitat Frankfurt, Marie Curie Strasse 11, 60439 Frankfurt, Germany
J Biol Chem 278:26174-82. 2003Pin1 is a peptidyl-prolyl cis/trans isomerase (PPIase) essential for cell cycle regulation...
- A nuclear FK506-binding protein is a histone chaperone regulating rDNA silencingTakashi Kuzuhara
Laboratory of Developmental Biology, Institute of Molecular and Cellular Biosciences, The University of Tokyo, 1 1 1 Yayoi, Bunkyo ku, Tokyo, 113 0032, Japan
Nat Struct Mol Biol 11:275-83. 2004..It is a member of the peptidyl prolyl cis-trans isomerase (PPIase) family, whose members were originally identified as enzymes that assist in the proper folding of polypeptides...
- RYR2 proteins contribute to the formation of Ca(2+) sparks in smooth muscleGuangju Ji
Department of Biomedical Sciences, Cornell University, Ithaca, NY 14853 6401, USA
J Gen Physiol 123:377-86. 2004....
- FK506 binding protein 12/12.6 depletion increases endothelial nitric oxide synthase threonine 495 phosphorylation and blood pressureCheng Long
Department of Molecular Physiology and Biophysics, Baylor College of Medicine, Houston, Tex 77030, USA
Hypertension 49:569-76. 2007..This molecular mechanism may, in part, explain rapamycin-induced hypertension...
- Requirements for peptidyl-prolyl isomerization activity: a comprehensive mutational analysis of the substrate-binding cavity of FK506-binding protein 12Teikichi Ikura
Laboratory of Structural Biology, School of Biomedical Science, Tokyo Medical and Dental University, Tokyo 113 8510, Japan
Protein Sci 16:2618-25. 2007Peptidyl-prolyl isomerase (PPIase) activity is exhibited by many proteins belonging to the PPIase family. However, the catalytic mechanism of this activity remains to be completely elucidated...
- Arrhythmogenesis in catecholaminergic polymorphic ventricular tachycardia: insights from a RyR2 R4496C knock-in mouse modelNian Liu
Molecular Cardiology, IRCCS Fondazione Salvatore Maugeri, Pavia, Italy
Circ Res 99:292-8. 2006..6 interaction in RyR2(R4496C+/-) is identical to that of WT both before and after epinephrine and caffeine, thus suggesting that it is unlikely that the R4496C mutation interferes with the RyR2/FKBP12.6 complex...
- Intracellular calcium leak due to FKBP12.6 deficiency in mice facilitates the inducibility of atrial fibrillationSubeena Sood
Department of Molecular Physiology and Biophysics, Houston, Texas 77030, USA
Heart Rhythm 5:1047-54. 2008..Studies in patients with AF revealed that impaired diastolic closure of sarcoplasmic reticulum (SR) Ca(2+)-release channels (ryanodine receptors, RyR2) is associated with reduced levels of the RyR2-inhibitory subunit FKBP12.6...
- Catecholaminergic polymorphic ventricular tachycardia: recent mechanistic insightsKimmo Kontula
Department of Medicine, University of Helsinki, 00290 Helsinki, Finland
Cardiovasc Res 67:379-87. 2005....
- The three-dimensional structure of two redox states of cyclophilin A from Schistosoma mansoni. Evidence for redox regulation of peptidyl-prolyl cis-trans isomerase activityLouise J Gourlay
Istituto Pasteur Fondazione Cenci Bolognetti, Department of Biochemical Sciences A Rossi Fanelli, Sapienza University of Rome, Piazzale Aldo Moro 5, 00185 Rome, Italy
J Biol Chem 282:24851-7. 2007....
- Defective cardiac ryanodine receptor regulation during atrial fibrillationJohn A Vest
Department of Physiology and Cellular Biophysics, Clyde and Helen Wu Center for Molecular Cardiology, Columbia University College of Physicians and Surgeons, New York, NY 10032, USA
Circulation 111:2025-32. 2005..6) causes SR Ca2+ leak in failing hearts and can trigger fatal ventricular arrhythmias. Little is known about the role of RyR2 dysfunction in AF, however...
- Mip protein of Legionella pneumophila exhibits peptidyl-prolyl-cis/trans isomerase (PPlase) activityG Fischer
Max Planck Gesellschaft, Arbeitsgruppe Enzymologie der Peptidbindung, Halle, Germany
Mol Microbiol 6:1375-83. 1992..FKBPs are able to bind to the immunosuppressant macrolide FK506 and possess peptidyl-prolyl cis/trans isomerase (PPIase) activity. The gene coding for the Mip protein was cloned from the chromosome of L...
- Identification of cyclophilin as a proinflammatory secretory product of lipopolysaccharide-activated macrophagesB Sherry
Laboratory of Medical Biochemistry, Rockefeller University, New York, NY 10021
Proc Natl Acad Sci U S A 89:3511-5. 1992....
- Cloning, expression, and purification of human cyclophilin in Escherichia coli and assessment of the catalytic role of cysteines by site-directed mutagenesisJ Liu
Department of Biological Chemistry and Molecular Pharmacology, Harvard Medical School, Boston, MA 02115
Proc Natl Acad Sci U S A 87:2304-8. 1990..fluorescence enhancement and for inhibition (IC50 = 19 nM) of cyclophilin's peptidyl-prolyl cis-trans isomerase (rotamase) activity...
- Molecular and biochemical characterization of a Plasmodium falciparum cyclophilin containing a cleavable signal sequenceJ Hirtzlin
Department of Structural Biology, Biozentrum, University of Basel, Switzerland
Eur J Biochem 232:765-72. 1995..immunosuppressive effect in T lymphocytes by binding to cyclophilin (CyP), a peptidylprolyl cis-trans isomerase (PPIase)...
- Complexes between porin, hexokinase, mitochondrial creatine kinase and adenylate translocator display properties of the permeability transition pore. Implication for regulation of permeability transition by the kinasesG Beutner
Faculty of Biology, University of Konstanz, Germany
Biochim Biophys Acta 1368:7-18. 1998..The inhibitory effect of N-methylVal-4-cyclosporin on the creatine kinase complex may be explained by direct interaction with the creatine kinase dimer that appeared to support octamer formation...
- Selective inactivation of parvulin-like peptidyl-prolyl cis/trans isomerases by jugloneL Hennig
Max Planck Research Unit, Enzymology of Protein Folding, Halle Saale, Germany
Biochemistry 37:5953-60. 1998..Thus, partial unfolding of the active site of the parvulins was thought to be the cause of the deterioration of PPIase activity.
- The Ess1 prolyl isomerase is linked to chromatin remodeling complexes and the general transcription machineryX Wu
Molecular Genetics Program, Wadsworth Center, New York State Department of Health, and Department of Biomedical Sciences, School of Public Health, State University of New York, Albany, NY 12208, USA
EMBO J 19:3727-38. 2000The Ess1/Pin1 peptidyl-prolyl isomerase (PPIase) is thought to control mitosis by binding to cell cycle regulatory proteins and altering their activity...
- Expression of long- and short-type FK506 binding proteins in hyperthermophilic archaeaAkira Ideno
Marine Biotechnology Institute, 3 75 1 Heita, Kamaishi, Iwate 026 0001, Japan
Gene 292:57-63. 2002..clarify the difference between their roles in archaeal cells, they were expressed in Escherichia coli, and their PPIase and chaperone-like protein-folding activities were investigated...
- 21-kDa polypeptide, a low-molecular-weight cyclophilin, is released from pollen of higher plants into the extracellular medium in vitroEtsuo Yokota
Department of Life Science, Graduate School of Science, Himeji Institute of Technology, Harima Science Park City, 678 1297 Hyogo, Japan
Planta 218:1008-18. 2004..From these results, we concluded that the 21-kDa polypeptide is a low-molecular-weight CyP. The present study showed that CyP in the pollen of higher plants is released into the extracellular matrix under unfavorable conditions...
- Ryanodine receptor regulation by intramolecular interaction between cytoplasmic and transmembrane domainsChristopher H George
Wales Heart Research Institute, Department of Cardiology, University of Wales College of Medicine, Cardiff, United Kingdom CF14 4XN
Mol Biol Cell 15:2627-38. 2004..These results provide compelling evidence that specific interaction between cytoplasmic and transmembrane domains is an important mechanism in the intrinsic modulation of RyR Ca(2+) release channels...
- The Arabidopsis cyclophilin gene familyPatrick G N Romano
Robert Hill Institute, Department of Molecular Biology and Biotechnology, University of Sheffield, Western Bank, Sheffield S10 2TN, United Kingdom
Plant Physiol 134:1268-82. 2004..As well as fulfilling the basic role of protein folding, they may also play important roles in mRNA processing, protein degradation, and signal transduction and thus may be crucial during both development and stress responsiveness...
- A note on clustering the functionally-related paralogues and orthologues of proteins: a case of the FK506-binding proteins (FKBPs)Andrzej Galat
Departement d Ingenierie et d Etudes des Proteines, Bat 152, DSV CEA, CE Saclay, F 91191 Gif sur Yvette Cedex, France
Comput Biol Chem 28:129-40. 2004..1 degrees apparent conservation of the crucial amino acid (AA) residues for peptidylprolyl cis/trans isomerase (PPIase) acitity and binding of some immunosuppressive drugs; 2 degrees convergence of the three mentioned above ..
- FK506-binding proteins 51 and 52 differentially regulate dynein interaction and nuclear translocation of the glucocorticoid receptor in mammalian cellsGabriela M Wochnik
Max Planck Institute of Psychiatry, Kraepelinstrasse 10, D 80804 Munich, Germany
J Biol Chem 280:4609-16. 2005..receptor signaling in mammalian cells: hsp90 interaction, dynein association, and peptidylprolyl isomerase (PPIase) enzyme activity...
- Polo-like kinase 1-mediated phosphorylation stabilizes Pin1 by inhibiting its ubiquitination in human cellsFrank Eckerdt
Department of Gynecology and Obstetrics, J W Goethe University, Theodor Stern Kai 7, Frankfurt D 60590, Germany
J Biol Chem 280:36575-83. 2005..Since previous reports suggested that Plk1 is a substrate of Pin1, our work adds a new dimension to this interaction of two important mitotic regulators...
- Gene expression profiling identifies FKBP39 as an inhibitor of autophagy in larval Drosophila fat bodyG Juhasz
Department of General Zoology, Eotvos Lorand University, Budapest, Hungary
Cell Death Differ 14:1181-90. 2007..Accordingly, we found that Foxo mutants cannot properly undergo autophagy in response to starvation, and that overexpression of Foxo induces autophagy...
- On the benefit of bivalency in peptide ligand/pin1 interactionsSebastian Daum
Max Planck Research Unit for Enzymology of Protein Folding, Weinbergweg 22, 06120 Halle Saale, Germany
J Mol Biol 374:147-61. 2007The human peptidyl prolyl cis/trans isomerase (PPIase) Pin1 has a key role in developmental processes and cell proliferation...
- Ryanodine receptor: a novel therapeutic target in heart diseaseRikuo Ochi
Department of Physiology, New York Medical College, Valhalla, NY 10595, USA
Recent Pat Cardiovasc Drug Discov 2:110-8. 2007....
- Requirements for surface expression and function of adhesin P1 from Streptococcus mutansPaula J Crowley
Department of Oral Biology, University of Florida, Gainesville, FL 32610, USA
Infect Immun 76:2456-68. 2008..It does not achieve a fully functional form in the absence of the trigger factor PPIase homolog RopA, and its translocation is delayed when DnaK levels are limited...
- Conditional FKBP12.6 overexpression in mouse cardiac myocytes prevents triggered ventricular tachycardia through specific alterations in excitation-contraction couplingBarnabas Gellen
INSERM, U698, Paris, France
Circulation 117:1778-86. 2008..6 from RyR2, leading to diastolic sarcoplasmic reticulum Ca(2+) leakage and ventricular tachycardia (VT). We tested the hypothesis that FKBP12.6 overexpression in cardiac myocytes can reduce susceptibility to VT in stress conditions...
- Cardioprotective effects of hydroxysafflor yellow A on diabetic cardiac insufficiency attributed to up-regulation of the expression of intracellular calcium handling proteins of sarcoplasmic reticulum in ratsHaibo He
Institute of Chinese Herbal Medicine, College of Pharmaceutical Sciences, Zhejiang University, Hangzhou, China
Phytother Res 22:1107-14. 2008....
- Separation/enrichment of active natural low content protein using protein imprinted polymerRuifang Han
Biochemical Section of Key Laboratory of Functional Polymer Materials, The Ministry of Education of China, Institute of Polymer Chemistry, Chemical School of Nankai University, Tianjin, PR China
J Chromatogr B Analyt Technol Biomed Life Sci 873:113-8. 2008..The assay of peptidyl-prolyl cis-trans-isomerase (PPIase) activity showed that natural pCyP18 is more active than cloned pCyP18 and, in particular, it is much more ..
- Involvement of cyclophilin D in mitochondrial permeability transition induction in intact cellsHidejiro Tazawa
Division of Biotechnology and Life Science, Institute of Symbiotic Science and Technology, Tokyo University of Agriculture and Technology, Nakacho 2 24 16, Koganei, Tokyo, Japan
Arch Biochem Biophys 481:59-64. 2009..The present study aimed to clarify the involvement of cyclophilin D, a peptidyl prolyl cis-trans isomerase (PPIase), in MPT induction in intact cells...
- A new method for purification of functional recombinant GST-cyclophilin A protein from E. coliSeonmin Lee
Department of Biochemistry and Molecular Biology, Medical Science and Engineering Research Center for Bioreaction to Reactive Oxygen Species and Biomedical Science Institute BK 21, School of Medicine, Kyung Hee University, Seoul 130 701, Korea
Indian J Biochem Biophys 45:374-8. 2008..A (CypA) fusion protein was obtained, without affecting the structural and functional characteristics such as PPIase and chaperone activities...
- Essential role of Pro 74 in stefin B amyloid-fibril formation: dual action of cyclophilin A on the processAida Smajlović
Department of Biochemistry, Farmaceutical Faculty, University of Tuzla, Tuzla, Bosnia and Herzegovina
FEBS Lett 583:1114-20. 2009..These results demonstrate that peptidyl prolyl cis/trans isomerism is rate-limiting in stefin B fibril formation...
- Application of SAIL phenylalanine and tyrosine with alternative isotope-labeling patterns for protein structure determinationMitsuhiro Takeda
Structural Biology Research Center, Nagoya University, Furo cho, Chikusa ku, Japan
J Biomol NMR 46:45-9. 2010..2 kDa protein, Escherichia coli peptidyl-prolyl cis-trans isomerase b (EPPIb), and concluded that the combined use of zeta-SAIL Phe and epsilon-SAIL Tyr would be practically the best choice for protein structural determinations...
- Peptidyl-prolyl isomerase activity in chloroplast thylakoid lumen is a dispensable function of immunophilins in Arabidopsis thalianaBjörn Ingelsson
Department of Clinical and Experimental Medicine, Linkoping University, SE 581 85 Linkoping, Sweden
Plant Cell Physiol 50:1801-14. 2009..folding catalysts, although only two of them, AtFKBP13 and AtCYP20-2, possess peptidyl-prolyl cis/trans isomerase (PPIase) activity...
- The Hsp90 cochaperone, FKBP51, increases Tau stability and polymerizes microtubulesUmesh K Jinwal
Johnnie B Byrd Sr Alzheimer s Research Institute and Department of Molecular Medicine, University of South Florida, Tampa, Florida 33613, USA
J Neurosci 30:591-9. 2010..which possesses both an Hsp90-interacting tetratricopeptide domain and a peptidyl-prolyl cis-trans isomerase (PPIase) domain, prevents tau clearance and regulates its phosphorylation status...
- Ca(2+) release induced by cADP-ribose is mediated by FKBP12.6 proteins in mouse bladder smooth muscleJi Zheng
Urological Surgery Research Institute, Southwest Hospital, Third Military Medical University, Chongqing, China
Cell Calcium 47:449-57. 2010..6. Finally, cADPR altered SR Ca(2+) load in WT myocytes but not in FKBP12.6-null myocytes. Taken together, these results suggest that Ca(2+) release induced by cADPR is mediated by FKBP12.6 proteins in mouse bladder smooth muscle...
- Intrinsically disordered regions may lower the hydration free energy in proteins: a case study of nudix hydrolase in the bacterium Deinococcus radioduransOmar Awile
Mediterranean Institute for Life Sciences, Split, Croatia
PLoS Comput Biol 6:e1000854. 2010..this group includes a number of housekeeping and repair proteins such as DNA polymerase III, nudix hydrolase and rotamase. Here, we focus on a member of the nudix hydrolase family from D...
- Altered expression and function of ryanodine receptors and FKBP12.6 after subarachnoid hemorrhage: more than meets the eyeWilliam F Jackson
Department of Pharmacology and Toxicology, Michigan State University, East Lansing, Michigan 48824, USA
J Cereb Blood Flow Metab 31:1-2. 2011..In addition, the mechanisms responsible for the measured changes in expression of ryanodine receptors and FKBP12.6 yet remain unknown. These topics should prove to be fertile ground for future studies...
- A Burkholderia pseudomallei macrophage infectivity potentiator-like protein has rapamycin-inhibitable peptidylprolyl isomerase activity and pleiotropic effects on virulenceIsobel H Norville
Defence Science and Technology Laboratory, Porton Down SP4 0JQ, UK
Infect Immun 79:4299-307. 2011..of the FK506-binding protein (FKBP) family, whose members typically exhibit peptidylprolyl cis-trans isomerase (PPIase) activity which is inhibitable by the immunosuppressants FK506 and rapamycin...
- Mitogen-activated protein kinase extracellular signal-regulated kinase 2 phosphorylates and promotes Pin1 protein-dependent promyelocytic leukemia protein turnoverJun Hee Lim
Department of Biochemistry, School of Medicine, Case Western Reserve University, Cleveland, Ohio 44106 4935, USA
J Biol Chem 286:44403-11. 2011..Taken together, our results support a model in which Pin1 promotes PML degradation in an ERK2-dependent manner...
- Differential expression of genes involved in alternative glycolytic pathways, phosphorus scavenging and recycling in response to aluminum and phosphorus interactions in Citrus rootsLin Tong Yang
College of Resources and Environmental Sciences, Fujian Agriculture and Forestry University, 350002, Fuzhou, China
Mol Biol Rep 39:6353-66. 2012..PPi-PFK), tonoplast adenosine-triphosphatase subunit A (V-ATPase A), tonoplast pyrophosphatase (V-PPiase), pyruvate kinase (PK), acid phosphatase (APase), phosphoenolpyruvate carboxylase (PEPC), malic enzyme (ME) and ..
- Cardiac FKBP12.6 overexpression protects against triggered ventricular tachycardia in pressure overloaded mouse heartsLaurent Vinet
Universite Paris Diderot, Sorbonne Paris Cité and Inserm UMR_S 698, 46, rue Henri Huchard, 75877, Paris Cedex 18, France
Basic Res Cardiol 107:246. 2012....
- Involvement of peptidylprolyl cis/trans isomerases in Enterococcus faecalis virulenceFany Reffuveille
USC INRA 2017, Microbiologie de l Environnement, EA956, Universite de Caen, Caen, France
Infect Immun 80:1728-35. 2012..faecalis stress response or virulence. The other two PPIases, the parvulin family rotamase EF0685 and the cyclophilin family member EF1534, are expected to be surface-exposed proteins...
- Biochemical characterization of two Azotobacter vinelandii FKBPs and analysis of their interaction with the small subunit of carbamoyl phosphate synthetaseMaria Dimou
Department of Agricultural Biotechnology, Agricultural University of Athens, Iera Odos 75, Votanikos, 11855 Athens, Greece
Mol Biol Rep 39:10003-12. 2012..AvfkbA1 and AvfkbA2, from the soil nitrogen-fixing bacterium Azotobacter vinelandii and show that both possess PPIase activity while AvfkbA2 possesses chaperone activity as well...
- Elucidating role of salivary proteins in denture stomatitis using a proteomic approachSompop Bencharit
Department of Prosthodontics, School of Dentistry, University of North Carolina, CB 7450, Chapel Hill, NC 27599, USA
Mol Biosyst 8:3216-23. 2012..Further examination in larger populations of these proteins may help to gain a better understanding of DS pathological processes and improve DS treatments...
- Overexpression of the prolyl isomerase PIN1 promotes cell growth in osteosarcoma cellsLu Zhou
Department of Orthopaedic Surgery, Chonbuk National University Medical School, Jeonju, Jeonbuk 561 756, Republic of Korea
Oncol Rep 29:193-8. 2013PIN1 was recently identified as a peptidyl-prolyl cis-trans isomerase (PPIase). It binds to and isomerizes specific pSer/Thr-Pro motifs and catalytically induces conformational changes after phosphorylation...
- Depressed calcium-handling proteins due to endoplasmic reticulum stress and apoptosis in the diabetic heart are attenuated by argireinF H Shi
Research Division of Pharmacology, China Pharmaceutical University, 24 Tongjia Lane, Nanjing, 210009, China
Naunyn Schmiedebergs Arch Pharmacol 386:521-31. 2013..AR has potential in managing DC through attenuating depressed calcium-handling proteins, activated ER stress, and apoptosis in the myocardium...
- Dietary vitamin D deficiency in rats from middle to old age leads to elevated tyrosine nitration and proteomics changes in levels of key proteins in brain: implications for low vitamin D-dependent age-related cognitive declineJeriel T R Keeney
Department of Chemistry, Center of Membrane Sciences, Sanders Brown Center on Aging, University of Kentucky, Lexington, KY 40506, USA
Free Radic Biol Med 65:324-34. 2013..Together, these results suggest that dietary VitD deficiency contributes to significant nitrosative stress in brain and may promote cognitive decline in middle-aged and elderly adults...
- FK506-binding protein 12 ligands: a patent reviewFei Liu
Nanjing Medical University, The First Affiliated Hospital, Research Division of Clinical Pharmacology, 300 Guangzhou Road, Nanjing, Jiangsu Province, 210029, China
Expert Opin Ther Pat 23:1435-49. 2013FK506-binding protein 12 (FKBP12) is an endogenous protein with peptidyl-prolyl isomerase (PPIase) activity...
- C-terminal 13-residue truncation induces compact trigger factor conformation and severely impairs its dimerization abilityYi Shi
Shanghai Advanced Research Institute, Chinese Academy of Sciences, No 99, Haike Road, Zhangjiang Hi Tech Park, Pudong, Shanghai, 201210, China
Protein Pept Lett 21:476-82. 2014..TF consists of an N-terminal ribosome binding domain, a middle peptidyl-prolyl cis/trans isomerase (PPIase) domain and a C-terminal domain involved in substrate binding and dimerization...
- Implication of PMLIV in both intrinsic and innate immunityFaten El Asmi
INSERM UMR S 1124, Paris, France Université Paris Descartes, Paris, France
PLoS Pathog 10:e1003975. 2014....
- Skp1-Cullin-F-box (SCF)-type ubiquitin ligase FBXW7 negatively regulates spermatogonial stem cell self-renewalMito Kanatsu-Shinohara
Department of Molecular Genetics, Graduate School of Medicine, Kyoto University, Kyoto 606 8501, Japan Precursory Research for Embryonic Science and Technology PRESTO and
Proc Natl Acad Sci U S A 111:8826-31. 2014..These results suggest that FBXW7 regulates SSC self-renewal in a negative manner by degradation of MYC. ..
- Bcl-2 and FKBP12 bind to IP3 and ryanodine receptors at overlapping sites: the complexity of protein-protein interactions for channel regulationTim Vervliet
KU Leuven, Laboratory of Molecular and Cellular Signaling, Department of Cellular and Molecular Medicine, Campus Gasthuisberg O N 1, Bus 802, B 3000 Leuven, Belgium
Biochem Soc Trans 43:396-404. 2015....
- Oxidation of ryanodine receptor (RyR) and calmodulin enhance Ca release and pathologically alter, RyR structure and calmodulin affinityTetsuro Oda
Department of Pharmacology University of California, Davis, CA, USA Department of Medicine and Clinical Science, Division of Cardiology, Yamaguchi University Graduate School of Medicine, Ube, Yamaguchi, Japan
J Mol Cell Cardiol 85:240-8. 2015..6-RyR2 affinity, and causes domain unzipping. Dantrolene can correct domain unzipping, restore CaM-RyR2 affinity, and quiet pathological RyR2 channel gating. F-DPc10 and CaM are useful biosensors of a pathophysiological RyR2 state. ..
- Physiological and Molecular Responses to Excess Boron in Citrus macrophylla WMary Rus Martínez-Cuenca
Department of Citriculture and Vegetal Production, Valencian Institute of Agrarian Research, Moncada, Valencia, Spain
PLoS ONE 10:e0134372. 2015..3- and 2.4-fold in leaves and roots, respectively. The activity of V-PPiase proton pump, related with the electrochemical gradient in the vacuole, was also enhanced in +B organs...
- PIN1 genetic polymorphisms and the susceptibility of HBV-related hepatocellular carcinoma in a Guangxi populationLi Huang
Department of Clinical Laboratory, First Affiliated Hospital of Guangxi Medical University, Nanning, Guangxi Zhuang Autonomous Region, 530021, China
Tumour Biol 37:6599-606. 2016..03-0.62, p = 0.003). In conclusion, this study's findings suggest that the PIN1 rs2233679 TT genotype, the rs2233682GA genotype, and A alleles might be associated with the HBV-related HCC in a Guangxi study population. ..
- Inhibition of Aβ(1-40) fibril formation by cyclophilinsMarten Villmow
Max Planck Research Unit for Enzymology of Protein Folding, Weinbergweg 22, D 06120 Halle Saale, Germany
Biochem J 473:1355-68. 2016....
- Conformational dynamics of Peb4 exhibit "mother's arms" chain model: a molecular dynamics studySarath Chandra Dantu
a Department of Biosciences and Bioengineering, Indian Institute of Technology Bombay, Powai, Mumbai 400076, India
J Biomol Struct Dyn . 2016..jejuni is an intertwined dimeric, periplasmic holdase, which also exhibits peptidyl prolyl cis/trans isomerase (PPIase) activity...
- Structural and functional analysis of cyclophilin PpiB mutants supports an in vivo function not limited to prolyl isomerization activityAggeliki Skagia
Laboratory of General and Agricultural Microbiology, Faculty of Crop Science, Agricultural University of Athens, Iera Odos 75, Votanikos, Athens, 11855, Greece
Genes Cells 22:32-44. 2017Escherichia coli cyclophilin PpiB is a peptidyl-prolyl cis/trans isomerase (PPIase, EC: 22.214.171.124), involved in the negative modulation of various bacterial processes, such as swimming and swarming motility and biofilm formation ability...
- Overexpression of phytochelatin synthase (pcs) enhances abiotic stress tolerance by altering the proteome of transformed Anabaena sp. PCC 7120Neha Chaurasia
Molecular Biology Section, Laboratory of Algal Biology, Center of Advanced Study in Botany, Institute of Science, Banaras Hindu University, Varanasi, 221005, India
Protoplasma . 2016..Such recombinant strains have potential for future use as biofertilizer...
- Cyclophilin-A is a zinc-dependent DNA binding protein in macrophagesU Krummrei
Institute of Experimental and Clinical Pharmacology and Toxicology, University of Erlangen Nurnberg, Germany
FEBS Lett 371:47-51. 1995..Peptidyl-prolyl cisltrans isomerase (PPIase) activity of nuclear CypA is inhibited by zinc ions. The zinc inhibited CypA does not bind cyclosporin A (CsA)...
- The CYP2 gene of Saccharomyces cerevisiae encodes a cyclosporin A-sensitive peptidyl-prolyl cis-trans isomerase with an N-terminal signal sequenceP L Koser
Department of Molecular Genetics, SmithKline Beecham Pharmaceuticals, King of Prussia, PA 19406
Gene 108:73-80. 1991..Saccharomyces cerevisiae contain a major cytosolic cyclophilin (Cyp)-related peptidyl-prolyl cis-trans isomerase (PPIase) which is the target for cyclosporin A (CsA) cytotoxicity and which is encoded by the CYP1 gene [Haendler et al...
- ALLOSTERIC SITE STRUCTURES OF CARDIOVASCULAR CHANNELSArthur Karlin; Fiscal Year: 2011..The results will provide insights into the molecular mechanisms of allosteric interactions in these two channels and will provide molecular structural bases for cardiovascular therapeutics targeted at these channels. ..
- RAZVAN LIVIU CORNEA; Fiscal Year: 2016..We will conduct fundamental quantitative molecular fluorescence studies that will clarify both structurally and functionally how FKBP binds to and regulates RyR function in the heart. ..
- Philip W Landfield; Fiscal Year: 2016..that suggests that downregulation of immunophilins, particularly FK-506 binding protein 1b and/or 1a (FKBP1b/1a), leads to a cascade of RyR destabilization, greater CICR and larger sAHPs...
- Chad A Dickey; Fiscal Year: 2016..both an Hsp90 interacting tetratricopeptide (TPR) domain and a cis-trans peptidyl-prolyl cis-trans isomerase (PPIase) domain, was found to prevent tau clearance and regulate its phosphorylation status...
- THE ROLE OF PIN1 IN MITOSIS WITH DESIGNED INHIBITORSFELICIA ETZKORN; Fiscal Year: 2002..the folding process is accelerated by the peptidyl-prolyl isomerase (PPIase enzymes)...
- SUBSTRATES FOR PEPTIDYL PROLYL CIS-TRANS ISOMERASE ASSAYRoger Tung; Fiscal Year: 1990....
- ANDREW ROBERT MARKS; Fiscal Year: 2016..The proposed studies are significant because they will provide novel insights concerning the mechanisms of HF progression. ..
- Lipid electrophile adduction of Pin1 and effects on substrate binding &activityChristopher D Aluise; Fiscal Year: 2013..The proposed research allows for significant insight into the cellular response to Pin1 protein modification as a consequence of lipid peroxidation. ..
- Regulation of Breast Cancer Growth by MLK-3AJAY NMN RANA; Fiscal Year: 2013..Further, our results will point to the possibility of utilizing MLK inhibitor(s) as a novel therapeutic intervention for breast cancer therapy. ..
- Yeast Ess1, a Conserved PPlase Essential for MitosisSteven D Hanes; Fiscal Year: 2010..One exception is a PPIase called Ess1, which is essential for growth in the yeast, Saccharomyces cerevisiae...
- ADP: A Master Regulator for Bioenergetics and Ca2+/ROS Signaling in HeartShey Shing Sheu; Fiscal Year: 2012..The exploratory and high-risk ideas in this application, if validated, will break new ground in a wide spectrum of disease mechanisms and treatments. ..
- Pin1-dependent telomere regulation in aging and Alzheimer's diseaseTae Ho Lee; Fiscal Year: 2010..This study will have a significant impact upon our basic understanding of AD, and might eventually facilitate the development of novel treatments of AD via targeting of telomere maintenance. ..
- Pin1-dependent telomere regulation in aging and Alzheimer's diseaseTae Ho Lee; Fiscal Year: 2013..These studies should provide novel insight into telomere maintenance during aging and AD, and might have novel implications for developing new therapies. ..
- The Importance of Prolyl 3-hydroxylation in recessive Osteogenesis ImperfectaERICA PAIGE HOMAN; Fiscal Year: 2013..In addition to its function as a 3-hydroxylase, CypB functions as a cis/trans isomerase (PPIase)...
- NANCY ELIZABETH FREITAG; Fiscal Year: 2016..The ultimate goal of the specific aims will be to elucidate how PrsA2 modulates the secretion and/or activity of virulence factors to promote bacterial pathogenesis in mammalian hosts. ..
- Genetic and Molecular Analyses of Protein Biogenesis in the NeuroretinaPaulo A Ferreira; Fiscal Year: 2013..Aim 3. Test the hypothesis that the cis-trans prolyl isomerase (PPIase) activity in the CY domain of RanBP2 controls the biogenesis of selective proteins that are critical to the ..
- TOWARDS RATIONALLY DESIGNED IMMUNOSUPPRESSANTSTIMOTHY CURRAN; Fiscal Year: 1992..when it is bound to cyclophilin, a cytoplasmic protein that possesses peptidyl prolyl cis-trans isomerase (rotamase) enzymatic activity...
- Cell Repolarization, Alternans, and ArrhythmogenesisDavid S Rosenbaum; Fiscal Year: 2010..These studies are expected to improve understanding of the functional organization of electrical activity in HF, and provide fundamentally novel insights into mechanisms and therapies for SCO. ..
- STRUCTURE/FUNCTION OF HIV1 CAPSID/CYCLOPHILIN COMPLEXWesley Sundquist; Fiscal Year: 2001..of Pro90 in CA bound to cyclophilin A suggests that this residue may act as a substrate for cyclophilin rotamase activity...
- Post-translation regulation of Listeria monocytogenes virulence factorsNANCY ELIZABETH FREITAG; Fiscal Year: 2010..monocytogenes-based vaccines for delivery of foreign antigens. ..
- Designed Inhibitors of Pin1 in MitosisFELICIA ETZKORN; Fiscal Year: 2009..The unique peptidyl-prolyl isomerase (PPIase) enzymatic activity of Pin1 in the regulation of biological processes is interesting for fundamental reasons...
- MINERALIZATION STUDIES RELATED TO ORAL BIOLOGYHARRISON ANDERSON; Fiscal Year: 2005..phosphatase (ALP), ATPase, nucleotide triphosphate pyrophosphohydrolase (NTPPase) and inorganic pyrophosphatase (PPiase), in regulating the mineralization of isolated MVs from rat growth plate, and in promoting or inhibiting in vivo ..
- COLLAGEN FOLDING IN PRESENCE OF CIS-TRANS ISOMERASEHans Peter Bachinger; Fiscal Year: 1990....
- STRUCTURE/FUNCTION ANALYSIS OF MITOTIC REGULATORSJOSEPH NOEL; Fiscal Year: 2001..The human peptidyl-prolyl cis-trans isomerase (PPIase) Pin1 is a conserved mitotic regulator essential for the G2 to M transition of the eukaryotic cell cycle...
- CATALYZED AMIDE ISOMERIZATION: SYNTHETIC ROTAMASESThomas Lectka; Fiscal Year: 2001..mild, selective catalysts for amide isomerization (AI), culminating in the systematic development of model rotamase enzymes that catalyze the folding of peptides through the cis-trans isomerization of proline residues...
- Role of the Prolylisomerase Pin1 in OncogenesisGerburg Wulf; Fiscal Year: 2007..4) To study the effect of the inhibition of Pin1's PPIase activity as potential cancer therapy in vitro and in vivo...
- Pore opening: A target for mitochondrial DNA mutationsH Zassenhaus; Fiscal Year: 2005..Since such mutations may be an important contributing factor for many adult-onset diseases, these studies may provide insights into novel therapeutic strategies. ..
- Mechanisms Regulation Functions of Airway Smooth MuscleReynold Panettieri; Fiscal Year: 2007..Thus, understanding the transcriptional mechanisms regulating the expression of inflammatory genes in ASM will likely lead to new therapeutic approaches for the treatment of asthma. ..
- CARDIAC AND SKELETAL MUSCLE CALCIUM RELEASE CHANNELSAndrew Marks; Fiscal Year: 2009..Thus, the proposed studies are highly relevant to human diseases including heart failure and cardiac arrhythmias. ..
- Heterogeneity of hypoxic Ca2+ release in pulmonary and *Yong Xiao Wang; Fiscal Year: 2006..The proposed studies are also of fundamental physiological significance with respect to the regulation of Ca2+ release in other cell types. ..
- Regulation of cardiac ion channel function via allosteric modulatorsAndrew Marks; Fiscal Year: 2007..The studies are significant because they may lead to a novel therapeutic approach based on allosteric modulation of RyR that can result in improved therapy for human cardiovascular diseases. ..
- Novel Signaling for Ca2+ and Release in Airway MyocytesYong Xiao Wang; Fiscal Year: 2007..6, and/or RyRs are ubiquitously expressed in a variety of cell types, the mechanistic findings from the proposed study will have general biological and pathological significance for various Ca2+-mediated cellular effects. ..
- Mechanisms for hypoxic Ca2+ release in pulmonary artery myocytesYong Xiao Wang; Fiscal Year: 2010..The findings from this proposal will enhance our understanding of cellular molecular mechanisms for hypoxic [Ca2+]i rise in PASMCs and associated HPV, and may lead to identify potential novel targets to treat pulmonary hypertension. ..
- The Role of PP2A in Yeast Cell Cycle ProgressionYu Jiang; Fiscal Year: 2009..To test the hypothesis that the Tap42-PP2Ac complex controls the G2 gene expression through the Fkh1/2 transcription factors. This study is part of our long-term goals to understand the role of PP2A in cell growth control. ..
- CONTROL OF MICROVASCULAR FUNCTION BY OXYGENWilliam Jackson; Fiscal Year: 2006....
- 2007 Vascular Cell Biology Gordon Research ConferenceBradford Berk; Fiscal Year: 2007..unreadable] [unreadable] [unreadable]..
- Mechanisms of RNA virus-host interactionSailen Barik; Fiscal Year: 2009..Together, these results should lead to a better understanding of the replication of RSV in particular and of RNA viruses in general, and pave the way for a more reliable management of the viral diseases. ..
- REVERSIBLE PROTEIN PHOSPHORYLATION IN APICOMPLEXANSSailen Barik; Fiscal Year: 2004..These results should form the cornerstone in the detailed elucidation of the regulatory pathways and possible drug-target interactions in Plasmodium in particular, and Apicomplexans in general. ..
- CARDIOVASCULAR RESEARCH TRAININGBradford Berk; Fiscal Year: 2004..The University of Rochester is a research-intensive institution with a long tradition and commitment to training investigators which should facilitate the success of this program in cardiovascular research. ..
- Interactions between ocular tissue and RSVSailen Barik; Fiscal Year: 2004..be proven, it would establish an animal model for RSV-eye interaction, and open new directions in ocular immunopathology, RNA virus-activated signaling pathways in the eye, and antiviral drug regimen targeting the eye ..
- Mechanisms of chemopreventive effect of resveratrolZigang Dong; Fiscal Year: 2009..Our long-term goal is to identify the molecular mechanism explaining the anti-tumor effect exhibited by resveratrol. Such knowledge will help in developing better chemopreventive agents with fewer side effects. ..
- Function and Regulation of Pin2/TRF1 and PinX1Kun Ping Lu; Fiscal Year: 2005..These studies should yield new insights into telomere maintenance, cell growth control and oncogenesis, and may lead to the development of new anticancer therapy. ..
- Study on Ultraviolet-induced Signal TransductionZigang Dong; Fiscal Year: 2010..These preclinical studies are designed to lead to the development of new strategies for the chemoprevention of human skin cancers. ..
- Docking Site Mutations in the Fe-and MoFe-proteins.Nara Gavini; Fiscal Year: 2002..We believe that these studies will provide new insights regarding how the components of this complex metalloenzyme maintain such high specificity in their interactions. ..
- REGULATION OF SARCOPLASMIC RETICULUM CA2+ RELEASEGerhard Meissner; Fiscal Year: 2009..abstract_text> ..
- INHIBITION OF CARCINOGENESIS BY TEA AND TEA CONSTITUENTSZigang Dong; Fiscal Year: 2010..abstract_text> ..
- Molecular basis of arsenic-induced cell transformationZigang Dong; Fiscal Year: 2007..Such knowledge will facilitate the design of more effective and specific strategies with fewer side effects for chemoprevention of arsenic-induced cancer. ..
- Function and Regulation of the Phosphorylation-Specific Prolyl lsomerase Pin 1Kun Ping Lu; Fiscal Year: 2010..In lay language, we have identified a new enzyme called Pin1 critical for cancer development and will continue to investigate the function and regulation of Pin1 during cancer development and hope to identify new drug targets. ..
- Anticarcinogenic Mechanisms of Tea ConstituentsZigang Dong; Fiscal Year: 2007....
- Prolyl Isomerase Pin 1 and NeurodegenerationKun Ping Lu; Fiscal Year: 2009..These studies should help elucidate the molecular mechanisms of AD and related disorders, and may also have novel implications for their therapies. ..