Gene Symbol: FAT1
Description: FAT atypical cadherin 1
Alias: CDHF7, CDHR8, FAT, ME5, hFat1, protocadherin Fat 1, FAT tumor suppressor 1, cadherin ME5, cadherin family member 7, cadherin-related family member 8, cadherin-related tumor suppressor homolog, protein fat homolog
Species: human

Top Publications

  1. ncbi Prenatal and postnatal transfer of fatty acids from mother to pup in the hooded seal
    S J Iverson
    Canadian Institute of Fisheries Technology, Technical University of Nova Scotia, Halifax
    J Comp Physiol B 165:1-12. 1995
  2. pmc Mammalian Fat1 cadherin regulates actin dynamics and cell-cell contact
    Takuji Tanoue
    RIKEN Center for Developmental Biology, Minatojima Minamimachi, Chuo Ku, Kobe 650 0047, Japan
    J Cell Biol 165:517-28. 2004
  3. ncbi Processing of the human protocadherin Fat1 and translocation of its cytoplasmic domain to the nucleus
    Thomas Magg
    University of Konstanz, Department of Biology, Box M648, D 78547 Konstanz, Germany
    Exp Cell Res 307:100-8. 2005
  4. ncbi Identification of homozygous deletions of tumor suppressor gene FAT in oral cancer using CGH-array
    K Nakaya
    Department of Oral and Maxillofacial Surgery, Organ Function Regenerative and Reconstructive Surgery, Ehime University Graduate School of Medicine, Toon City, Ehime, Japan
    Oncogene 26:5300-8. 2007
  5. doi The ubiquitin-like modifier FAT10 interacts with HDAC6 and localizes to aggresomes under proteasome inhibition
    Birte Kalveram
    Department of Biology, Division of Immunology, University of Constance, Universitatsstrasse 10, 78457 Konstanz, Germany
    J Cell Sci 121:4079-88. 2008
  6. pmc Atrophin proteins interact with the Fat1 cadherin and regulate migration and orientation in vascular smooth muscle cells
    Rong Hou
    Department of Medicine, Cardiovascular Division, Albert Einstein College of Medicine, Bronx, New York 10461 1602, USA
    J Biol Chem 284:6955-65. 2009
  7. doi Human FAT1 cadherin controls cell migration and invasion of oral squamous cell carcinoma through the localization of β-catenin
    Yukiko Nishikawa
    Department of Oral and Maxillofacial Surgery, Ehime University Graduate School of Medicine, Ehime 791 0295, Japan
    Oncol Rep 26:587-92. 2011
  8. pmc Dual processing of FAT1 cadherin protein by human melanoma cells generates distinct protein products
    Elham Sadeqzadeh
    Cancer Research Unit, School of Biomedical Sciences and Pharmacy, University of Newcastle, Callaghan, New South Wales 2308, Australia
    J Biol Chem 286:28181-91. 2011
  9. doi The Fat1 cadherin is overexpressed and an independent prognostic factor for survival in paired diagnosis-relapse samples of precursor B-cell acute lymphoblastic leukemia
    C E de Bock
    Cancer Research Unit, School of Biomedical Sciences and Pharmacy, University of Newcastle, Callaghan, New South Wales, Australia
    Leukemia 26:918-26. 2012
  10. ncbi FAT1 acts as an upstream regulator of oncogenic and inflammatory pathways, via PDCD4, in glioma cells
    B Dikshit
    Department of Biochemistry, All India Institute of Medical Sciences AIIMS, New Delhi, India
    Oncogene 32:3798-808. 2013

Detail Information

Publications2632 found, 100 shown here

  1. ncbi Prenatal and postnatal transfer of fatty acids from mother to pup in the hooded seal
    S J Iverson
    Canadian Institute of Fisheries Technology, Technical University of Nova Scotia, Halifax
    J Comp Physiol B 165:1-12. 1995
    ..period of only 4 days, fasting mothers mobilize enormous amounts of lipid from blubber and secrete milk (60% fat) at rates of 10 kg.day-1. Pups gain 7 kg.day-1 due primarily to the deposition of fat in blubber...
  2. pmc Mammalian Fat1 cadherin regulates actin dynamics and cell-cell contact
    Takuji Tanoue
    RIKEN Center for Developmental Biology, Minatojima Minamimachi, Chuo Ku, Kobe 650 0047, Japan
    J Cell Biol 165:517-28. 2004
    ..In this work, we investigated the function of a mammalian Fat cadherin. Fat1 was localized at filopodial tips, lamellipodial edges, and cell-cell boundaries, overlapping with dynamic actin ..
  3. ncbi Processing of the human protocadherin Fat1 and translocation of its cytoplasmic domain to the nucleus
    Thomas Magg
    University of Konstanz, Department of Biology, Box M648, D 78547 Konstanz, Germany
    Exp Cell Res 307:100-8. 2005
    The giant protein hFat1, a member of the cadherin superfamily, has been proposed to play roles in cerebral development, glomerular slit formation, and also to act as a tumor suppressor, but its mechanisms of action have not been ..
  4. ncbi Identification of homozygous deletions of tumor suppressor gene FAT in oral cancer using CGH-array
    K Nakaya
    Department of Oral and Maxillofacial Surgery, Organ Function Regenerative and Reconstructive Surgery, Ehime University Graduate School of Medicine, Toon City, Ehime, Japan
    Oncogene 26:5300-8. 2007
    ..We identified a homozygous loss of FAT (4q35), a new member of the human cadherin superfamily, from genome-wide screening of copy number alterations in ..
  5. doi The ubiquitin-like modifier FAT10 interacts with HDAC6 and localizes to aggresomes under proteasome inhibition
    Birte Kalveram
    Department of Biology, Division of Immunology, University of Constance, Universitatsstrasse 10, 78457 Konstanz, Germany
    J Cell Sci 121:4079-88. 2008
  6. pmc Atrophin proteins interact with the Fat1 cadherin and regulate migration and orientation in vascular smooth muscle cells
    Rong Hou
    Department of Medicine, Cardiovascular Division, Albert Einstein College of Medicine, Bronx, New York 10461 1602, USA
    J Biol Chem 284:6955-65. 2009
    b>Fat1, an atypical cadherin induced robustly after arterial injury, has significant effects on mammalian vascular smooth muscle cell (VSMC) growth and migration...
  7. doi Human FAT1 cadherin controls cell migration and invasion of oral squamous cell carcinoma through the localization of β-catenin
    Yukiko Nishikawa
    Department of Oral and Maxillofacial Surgery, Ehime University Graduate School of Medicine, Ehime 791 0295, Japan
    Oncol Rep 26:587-92. 2011
    b>FAT1 [Homo sapiens FAT tumor suppressor homolog 1 (Drosophila)] is an intrinsic membrane protein classified as a member of the cadherin superfamily...
  8. pmc Dual processing of FAT1 cadherin protein by human melanoma cells generates distinct protein products
    Elham Sadeqzadeh
    Cancer Research Unit, School of Biomedical Sciences and Pharmacy, University of Newcastle, Callaghan, New South Wales 2308, Australia
    J Biol Chem 286:28181-91. 2011
    The giant cadherin FAT1 is one of four vertebrate orthologues of the Drosophila tumor suppressor fat. It engages in several functions, including cell polarity and migration, and in Hippo signaling during development...
  9. doi The Fat1 cadherin is overexpressed and an independent prognostic factor for survival in paired diagnosis-relapse samples of precursor B-cell acute lymphoblastic leukemia
    C E de Bock
    Cancer Research Unit, School of Biomedical Sciences and Pharmacy, University of Newcastle, Callaghan, New South Wales, Australia
    Leukemia 26:918-26. 2012
    ..Previously, the altered expression of Fat1 cadherin has been implicated in a number of solid tumors...
  10. ncbi FAT1 acts as an upstream regulator of oncogenic and inflammatory pathways, via PDCD4, in glioma cells
    B Dikshit
    Department of Biochemistry, All India Institute of Medical Sciences AIIMS, New Delhi, India
    Oncogene 32:3798-808. 2013
    ..Here we have studied the FAT1 (Homo sapiens FAT tumor-suppressor homolog 1 (Drosophila)) gene to identify its role in the tumorigenecity of the ..
  11. pmc Recurrent somatic mutation of FAT1 in multiple human cancers leads to aberrant Wnt activation
    Luc G T Morris
    Human Oncology and Pathogenesis Program, Memorial Sloan Kettering Cancer Center, New York, New York, USA
    Nat Genet 45:253-61. 2013
    ..Here, we report recurrent somatic mutations of the Drosophila melanogaster tumor suppressor-related gene FAT1 in glioblastoma (20.5%), colorectal cancer (7.7%), and head and neck cancer (6.7%)...
  12. pmc Frequent loss of heterozygosity and altered expression of the candidate tumor suppressor gene 'FAT' in human astrocytic tumors
    Kunzang Chosdol
    Department of Biochemistry, All India Institute of Medical Sciences, New Delhi, India
    BMC Cancer 9:5. 2009
    ..This has the advantage that DNA fingerprinting identifies the genetic alterations in a manner not biased for locus...
  13. ncbi Molecular cloning and tissue expression of FAT, the human homologue of the Drosophila fat gene that is located on chromosome 4q34-q35 and encodes a putative adhesion molecule
    J Dunne
    Laboratory of Lymphocyte Molecular Biology, Imperial Cancer Research Fund, London, United Kingdom
    Genomics 30:207-23. 1995
    b>FAT, a new member of the human cadherin super-family, has been isolated from the T-leukemia cell line J6...
  14. ncbi Differentially spliced isoforms of FAT1 are asymmetrically distributed within migrating cells
    Gerald S Braun
    Institute for Anatomy and Cell Biology 1, University of Heidelberg, 69120 Heidelberg, Germany
    J Biol Chem 282:22823-33. 2007
    Cadherin FAT1 is localized along the leading edge of mammalian cells and is necessary for polarization and directed migration...
  15. ncbi The OB protein (leptin) pathway--a link between adipose tissue mass and central neural networks
    L A Campfield
    Department of Metabolic Diseases, Hoffmann-La Roche Inc, Nutley, NJ 07110, USA
    Horm Metab Res 28:619-32. 1996
    ..OB protein provides a communication link from fat tissue and the brain...
  16. ncbi Characterization of the molecular mode of action of the sulfonylurea, glimepiride, at adipocytes
    G Muller
    Hoechst AG Frankfurt, Germany
    Horm Metab Res 28:469-87. 1996
    ..tissues would imply a similar ranking between the two drugs in glucose utilizing processes in isolated muscle and fat cells...
  17. ncbi Diet, antioxidant vitamins, oxidative stress and risk of coronary artery disease: the Peerzada Prospective Study
    R B Singh
    Centre of Nutrition Research, Medical Hospital and Research Centre, Moradabad, Varanasi College for Women Trivandrum, India
    Acta Cardiol 49:453-67. 1994
    ..Compared with British population, the Indian urbans consumed less total and saturated fat and cholesterol and more polyunsaturated fat and complex carbohydrates...
  18. ncbi Pilot study of dietary fat restriction and flaxseed supplementation in men with prostate cancer before surgery: exploring the effects on hormonal levels, prostate-specific antigen, and histopathologic features
    W Demark-Wahnefried
    Division of Urologic Surgery, Duke University Medical Center, Durham, North Carolina, USA
    Urology 58:47-52. 2001
    OBJECTIVES: Dietary fat and fiber affect hormonal levels and may influence cancer progression. Flaxseed is a rich source of lignan and omega-3 fatty acids and may thwart prostate cancer...
  19. ncbi Lewis phenotypes and the insulin resistance syndrome in young healthy white men and women
    J O Clausen
    Medical Department C, Glostrup Hospital, Copenhagen, Denmark
    Am J Hypertens 8:1060-6. 1995
    ..0024). They also had higher values of BMI (8%, P = .016), total body fat mass (25%, P = .015), fasting values of serum insulin (32%, P = .006), serum C-peptide (20%, P = ...
  20. ncbi Genetic basis of familial dyslipidemia and hypertension: 15-year results from Utah
    R R Williams
    Department of Internal Medicine, University of Utah Cardiovascular Genetics Research Clinic, Salt Lake City 84108
    Am J Hypertens 6:319S-327S. 1993
    ..associated with hypertension (erythrocyte sodium-lithium countertransport, intraerythrocytic sodium, a relative fat pattern, total urinary kallikrein excretion, and fasting insulin levels)...
  21. ncbi Bile acids in the assessment of hepatocellular function
    M B Thompson
    Laboratory of Experimental Pathology, National Institute of Environmental Health Sciences, Research Triangle Park, North Carolina 27709, USA
    Toxicol Pathol 24:62-71. 1996
    ..in the production of bile flow, excretion of cholesterol, and intestinal digestion and absorption of fats and fat-soluble vitamins...
  22. ncbi The role of diet history and biologic assays in the study of "diet and breast cancer"
    M Gerber
    INSERM Centre Paul Lamarque, Montpellier, France
    Tumori 76:321-30. 1990
    ..A significant difference was found between cases and controls in total fat and cholesterol intake in both populations, and in saturated fatty acid and mono-unsaturated fatty acid consumption ..
  23. ncbi Serum leptin concentrations during short-term administration of growth hormone and triiodothyronine in healthy adults: a randomised, double-blind placebo-controlled study
    T Wolthers
    Medical Department of M (Endocrinology and Diabetes, Aarhus University Hospital, , Denmark
    Horm Metab Res 31:37-40. 1999
    ..Leptin is supposed to serve both as an index of fat mass and as a sensor of energy balance...
  24. pmc Obesity
    C W Callaway
    Center for Clinical Nutrition, George Washington University Medical Center, Washington, DC
    Public Health Rep 102:26-9. 1987
    ..are needed: personal-demographic data, developmental patterns, family history, energy balance, body composition/fat distribution, psychological/behavioral measures, endocrine/metabolic measures, complications and associated ..
  25. ncbi [Computerized tomography of pancreatic tumors]
    R Fargnoli
    Ospedale Misericordia e Dolce, Prato, Italia
    Tumori 85:S3-5. 1999
    ..portal, splenic, superior mesenteric) appear as soft-tissue attenuation thickening obscuring the perivascular fat, with deformity, thrombosis or occlusion of the vessels...
  26. pmc Relation of infant diet to childhood health: seven year follow up of cohort of children in Dundee infant feeding study
    A C Wilson
    Department of Child Health, Ninewells Hospital and Medical School, Dundee
    BMJ 316:21-5. 1998
    ..9-10.0) years). MAIN OUTCOME MEASURES: Respiratory illness, weight, height, body mass index, percentage body fat, and blood pressure in relation to duration of breast feeding and timing of introduction of solids...
  27. ncbi Nodular tuberculid: a report of four patients
    H F Jordaan
    Departments of Dermatology, University of Stellenbosch and Tygerberg Hospital, Tygerberg, South Africa
    Pediatr Dermatol 17:183-8. 2000
    ..with nodules on the legs in whom the pathologic changes were situated in the deep dermis and adjacent subcutaneous fat. Nodular tuberculid (NT) is regarded as a suitable term for these lesions. All patients were female...
  28. ncbi Plasma renin activity and insulin resistance in African American and white children: the Bogalusa Heart Study
    W Chen
    Tulane Center for Cardiovascular Health, School of Public Health and Tropical Medicine, Tulane University Medical Center, New Orleans, Louisiana 70112, USA
    Am J Hypertens 14:212-7. 2001
    ..19, P < .05) only in white children. Other components of insulin resistance syndrome (percent body fat, systolic blood pressure, high-density lipoprotein cholesterol, and triglycerides) showed no relation to renin in ..
  29. ncbi Prolonged oral glucose tolerance test combined with indirect calorimetry and estimation of several substrates and hormones in obese subjects
    J Sonka
    Laboratory for Endocrinology and Metabolism, Ist Medical Faculty, Charles University, Prague, Czech Republic
    Acta Univ Carol Med (Praha) 39:39-47. 1993
    ..The correlations brought additional information. Insulinemia increased parallel with the amount of body fat. The basal level was decisive for most hormones and substrates--the high or low set level could be followed in the ..
  30. ncbi The role of TNF-alpha in human adipose tissue: prevention of weight gain at the expense of insulin resistance?
    F Hube
    German Diabetes Research Institute at the Heinrich Heine University, Dusseldorf
    Horm Metab Res 31:626-31. 1999
    Since evidence has appeared that tumor necrosis factor-alpha (TNF) is involved in the loss of body fat in the course of wasting diseases, a large number of studies have investigated the physiological role of this cytokine in adipose ..
  31. ncbi The diet and moderate exercise trial (DAMET): results after 24 weeks
    R B Singh
    Heart Research Laboratory, Medical Hospital and Research Centre, Morabadad, India
    Acta Cardiol 47:543-57. 1992
    W.H.O. and U.S. Dept. of Health and Human Services advocate a fat-modified, fruits and vegetable-enriched diet in conjunction with mode-rate physical activity for fitness and health...
  32. ncbi Anthropometric variables and metabolism in polycystic ovarian disease
    M Rebuffe-Scrive
    Department of Medicine I, University of Goteborg, Sweden
    Horm Metab Res 21:391-7. 1989
    ..glucose tolerance, plasma triglycerides and blood pressure were not different in spite of almost twice the body fat mass in the obese PCO women...
  33. ncbi Diet: the neglected variable in chemical safety evaluations
    P M Newberne
    Department of Pathology, Boston University School of Medicine, Massachusetts, USA
    Toxicol Pathol 24:746-56. 1996
    ..do occur in commercial animal diets; that essential nutrients, including total calories, protein and fat, can be provided in less or more than adequate amounts for the species of animal used in safety evaluations; and ..
  34. ncbi The impact of dietary fats, photoperiod, temperature and season on morphological variables, torpor patterns, and brown adipose tissue fatty acid composition of hamsters, Phodopus sungorus
    F Geiser
    , Marburg, Germany
    J Comp Physiol B 165:406-15. 1995
    ..oil (rich in monounsaturated fatty acids) and least pronounced in individuals on a diet containing 10% coconut fat (rich in saturated fatty acids). Torpor in P...
  35. ncbi Testosterone enhances estradiol's effects on postmenopausal bone density and sexuality
    S R Davis
    Prince Henry's Institute of Medical Research, Clayton, Victoria, Australia
    Maturitas 21:227-36. 1995
    ..035) and relevancy (P < 0.05). Total cholesterol and LDL-cholesterol fell in both groups as did total body fat. Total body fat-free mass (DEXA, anthropometry, impedance) increased in the E&T group only...
  36. ncbi Diet, overfeeding, and moderate dietary restriction in control Sprague-Dawley rats: I. Effects on spontaneous neoplasms
    K P Keenan
    Department of Safety Assessment, Merck Research Laboratories, West Point, Pennsylvania 19486, USA
    Toxicol Pathol 23:269-86. 1995
    ..SD rats were fed Purina Rodent Chow 5002 or a modified Rodent Chow 5002-9 containing lower protein, fat, metabolizable energy and increased fiber by AL or by DR at 65% of the AL amount by measurement or time (6.5 hr)...
  37. ncbi Milk intake, growth and energy consumption in pups of ice-breeding grey seals (Halichoerus grypus) from the Gulf of St. Lawrence, Canada
    C Lydersen
    University of Oslo, Department of Biology, Norway
    J Comp Physiol B 164:585-92. 1995
    ..5 +/- 8.4%. Pups were gaining a daily average of 2.0 +/- 0.7 kg (n = 12), of which 75% was fat, 3% protein and 22% water. The total water influx was measured to be 43.23 +/- 8.07 ml.kg-1.day-1...
  38. ncbi Dental status, diet and cardiovascular risk factors in middle-aged people in northern Sweden
    I Johansson
    Department of Nutritional Research, , Sweden
    Community Dent Oral Epidemiol 22:431-6. 1994
    ..Edentulous men also ate less fruits, vegetables and fibre and edentulous women ate more fat than dentates...
  39. ncbi Reversible insulin resistance in non-insulin-dependent diabetes mellitus
    J H Karam
    Metabolic Research Unit, University of California, San Francisco, USA
    Horm Metab Res 28:440-4. 1996
    ..Newer computerized tomography scans allow quantitation of fat accumulating in visceral organs including the mesentery and omentum...
  40. ncbi [Determinants of the left ventricular mass in obese patients. Influence of lean body mass]
    A Avignon
    , , Montpellier
    Arch Mal Coeur Vaiss 90:1043-6. 1997
    ..5-52.2 Kg/m2). Lean and fat body mass were determined by bio-impedancemetry, insulin sensitivity (Si) by the minimal model (Bergman), and basal ..
  41. pmc A social marketing campaign to promote low-fat milk consumption in an inner-city Latino community
    H Wechsler
    Department of Health Education, Teachers College, Columbia University, New York, NY
    Public Health Rep 107:202-7. 1992
    The authors proposed the Lowfat Milk Campaign, a multifaceted social marketing campaign to promote the use of low-fat milk in the Washington Heights-Inwood neighborhood of New York City, a low-income, inner-city, Latino community...
  42. ncbi Determination of neutral lipids from subcutaneous fat of cured ham by capillary gas chromatography and liquid chromatography
    J A Garcia Regueiro
    IRTA, Unitat de Tecnologia Analítica, Centre de Tecnologia de la Carn, Monells Girona, Spain
    J Chromatogr A 667:225-33. 1994
    The determination of neutral lipids in fat of cured ham is reported...
  43. ncbi Effect of dietary counselling on blood pressure and arterial plasma catecholamines in primary hypertension
    S L Beckmann
    Department of Internal Medicine, Ullevaal Hospital, University of Oslo, Norway
    Am J Hypertens 8:704-11. 1995
    ..The intervention group was advised to use less sodium chloride in their diet, and if necessary, less saturated fat and decrease body weight. They attended regular clinic visits as did the blood pressure control group...
  44. ncbi Vitamin D is related to blood pressure and other cardiovascular risk factors in middle-aged men
    L Lind
    Department of Internal Medicine, University Hospital, Uppsala, Sweden
    Am J Hypertens 8:894-901. 1995
    ..in 34 middle-aged men and metabolic cardiovascular risk factors were evaluated by means of intravenous glucose and fat tolerance tests, euglycemic hyperinsulinemic clamp, lipoprotein measurements, and lipoprotein lipase activity ..
  45. ncbi Evaluation of nutritional status of male population from mining vocational schools in the Lublin coal basin
    W Barud
    , Akademia Medyczna w Lublinie
    Ann Univ Mariae Curie Sklodowska Med 46:45-50. 1991
    ..at considerably rare deficiency of proteins and calories is incorrect composition of diet with the excess of animal fat and carbohydrates...
  46. ncbi An apocrine membrane antigen with polarized distribution and hormonally regulated expression in human endometrial and mammary carcinoma cell lines
    L M Forsman
    Department of Pathology, University of Helsinki, Finland
    Acta Pathol Microbiol Immunol Scand A 95:315-23. 1987
    ..lines (MCF-7 and T47-D), using an antiserum raised against glycoproteins which had been isolated from human milk fat globule membranes...
  47. ncbi Inhibitors of sterol synthesis. Morphological studies in rats after dietary administration of 5 alpha-cholest-8(14)-en-3 beta-ol-15-one, a potent hypocholesterolemic compound
    J H Smith
    Department of Pathology and Laboratory Medicine, College of Medicine, Texas A and M University, College Station 77843 1114
    Toxicol Pathol 17:506-15. 1989
    ..Diminished fat was also noted in the pair-fed controls and was presumably due to decreased food consumption...
  48. ncbi Selective, solid-matrix dispersion extraction of organophosphate pesticide residues from milk
    A Di Muccio
    , Rome, Italy
    J Chromatogr A 754:497-506. 1996
    ..Recovery experiments were carried out on homogenized commercial milk (3.6% fat content) spiked with ethanolic solutions of 24 OP pesticides, viz...
  49. ncbi [Twenty-four hour time and frequency domain variability of systolic blood pressure and heart rate in an experimental model of arterial hypertension plus obesity]
    M Pelat
    , INSERM U317, , Toulouse
    Arch Mal Coeur Vaiss 91:999-1002. 1998
    ..the 24 h SBPV and HRV in both time and frequency domains during weight increase in dogs fed ad libitum with a high fat diet...
  50. pmc Atherosclerotic risk factors are less intensively treated in patients with peripheral arterial disease than in patients with coronary artery disease
    M M McDermott
    Department of Medicine, Northwestern University Medical School Chicago, IL 60611, USA
    J Gen Intern Med 12:209-15. 1997
    ..08) and more CAD patients recalled a physician's instruction to follow a low-fat, low-cholesterol diet (94% vs 83%, p = .01)...
  51. ncbi Pathomechanism of pain-related behavior produced by allografts of intervertebral disc in the rat
    M Kawakami
    Department of Orthopedic Surgery, Wakayama Medical College, Japan
    Spine (Phila Pa 1976) 21:2101-7. 1996
    ..METHODS: Fat, nucleus pulposus, and anulus fibrosus were allografted into the epidural space at L6 in the rat...
  52. ncbi Double-contrast barium enema and computerised tomography in the pre-operative evaluation of rectal carcinoma: are they still useful diagnostic procedures?
    E M Civelli
    Department of Radiology, Istituto Nazionale perlo Studio e la Cura dei Tumori, Milan, Italy
    Tumori 86:389-92. 2000
  53. ncbi Lipogenic enzymes of rat liver and adipose tissue. Dietary variations and effect of polychlorinated biphenyls
    M Boll
    Abteilung Zellchemie, National Center for Environment and Health, , Germany
    Z Naturforsch C 49:665-78. 1994
    ..The extent of increase depended on the carbohydrate and fat content of the diet...
  54. pmc Transfer of DDT used in malaria control to infants via breast milk
    H Bouwman
    Department of Zoology, University for Christian Higher Education, Potchefstroom, South Africa
    Bull World Health Organ 70:241-50. 1992
    ..03 micrograms.l-1 and that in the breast milk, 15.06 mg.kg-1 (milk fat)...
  55. ncbi Energetics of lactation in harp seals (Phoca groenlandica) from the Gulf of St. Lawrence, Canada
    C Lydersen
    Norwegian Polar Institute, , Norway
    J Comp Physiol B 166:295-304. 1996
    ..depending on the age of the pups, but over the whole nursing period approximately half of the tissue was stored as fat. Harp seal mothers lost an average of 3...
  56. ncbi Defective insulin-induced GLUT4 translocation in skeletal muscle of high fat-fed rats is associated with alterations in both Akt/protein kinase B and atypical protein kinase C (zeta/lambda) activities
    F Tremblay
    Department of Physiology, Laval University Hospital Research Center, Quebec, Canada
    Diabetes 50:1901-10. 2001
    The cellular mechanism by which high-fat feeding induces skeletal muscle insulin resistance was investigated in the present study. Insulin-stimulated glucose transport was impaired ( approximately 40-60%) in muscles of high fat-fed rats...
  57. ncbi The role of phospholipase A2 and nitric oxide in pain-related behavior produced by an allograft of intervertebral disc material to the sciatic nerve of the rat
    M Kawakami
    Department of Orthopedic Surgery, Wakayama Medical College, Japan
    Spine (Phila Pa 1976) 22:1074-9. 1997
    ..in five groups of rats: The control group (no treatment), the sham group (exposure of the sciatic nerve only), the fat group (allografted fat on the sciatic nerve), the nucleus pulposus group (allografted nucleus pulposus) and the ..
  58. ncbi Effects of chronic combined treatment with captopril and pravastatin on the progression of insulin resistance and cardiovascular alterations in an experimental model of obesity in dogs
    E Villa
    Department of Endocrinology, , , Madrid, Spain
    Am J Hypertens 11:844-51. 1998
    ..Control animals were maintained with a regular diet, while the 15 remaining animals were fed a high-fat diet...
  59. pmc Assessing cardiovascular disease risk in women: a cultural approach
    J P Covington
    Department of General Preventive Medicine, Johns Hopkins University, Bloomberg School of Public Health, Baltimore, Maryland, USA
    J Natl Med Assoc 93:430-5. 2001
    ..Being heavy was not necessarily equated with being fat and was felt at least partially to reflect muscle tone and muscle mass...
  60. ncbi Localization, cellular morphology and respiratory capacity of "brown" adipose tissue in newborn reindeer
    P Soppela
    Finnish Game and Fisheries Institute, Reindeer Research, Rovaniemi, Finland
    Comp Biochem Physiol Comp Physiol 101:281-93. 1992
    ..had all the typical cell morphological characteristics of brown adipose tissue: abundant mitochondria, multilocular fat, high vascularization and a dense spot-like sympathetic innervation between the adipocytes...
  61. ncbi The effect of unsaturated and saturated dietary lipids on the pattern of daily torpor and the fatty acid composition of tissues and membranes of the deer mouse Peromyscus maniculatus
    F Geiser
    Department of Zoology, University of New England, Armidale, New South Wales, Australia
    J Comp Physiol B 161:590-7. 1991
    ..with rodent chow (control diet) or rodent chow with either 10% sunflower seed oil (unsaturated diet) or 10% sheep fat (saturated diet)...
  62. ncbi [Experimental hypertension induced by hypercaloric diet]
    P Verwaerde
    , INSERM U317, , Toulouse
    Arch Mal Coeur Vaiss 89:1019-23. 1996
    ..The aim of this study was to investigate cardiovascular modifications elicited by high fat diet. Four male Beagle-Harrier dogs were used in this preliminary study...
  63. ncbi Energy intake and utilisation by nursing bearded seal (Erignathus barbatus) pups from Svalbard, Norway
    C Lydersen
    Norwegian Polar Institute, , Norway
    J Comp Physiol B 166:405-11. 1996
    ..Pups gained 3.3 +/- 0.4 kg.day-1 of which 50% was fat, 14% protein and 36% water. Average daily water influx for the pups was 69.5 +/- 9.0 ml.kg-1. day-1...
  64. ncbi Retrobulbar adipocytes and humoral immunity in Graves' ophthalmopathy
    C Hansen
    III. Medizinische Klinik, Johannes-Gutenberg-Universitat, Klinikum Mainz, Germany
    Horm Metab Res 25:618-22. 1993
    As CT and MR-imaging revealed an enlargement of retrobulbar fat tissue in patients with Graves' ophthalmopathy, the role of the retrobulbar adipocytes in the pathogenesis of this disorder remains to be elucidated...
  65. ncbi Prevalence of coronary artery disease and its risk factors in the urban population of South and North India
    R Begom
    Department of Home Science, College for Women, Medical Hospital and Research Centre, Moradabad, India
    Acta Cardiol 50:227-40. 1995
    ..3%) was significantly higher in South Indian females which may be the cause of higher CAD among them. While total fat intake in North and South Indians were comparable, the intake of saturated fat and cholesterol were higher and P/S ..
  66. ncbi Circulating TNF-alpha and leptin levels in offspring of NIDDM patients do not correlate to individual insulin sensitivity
    M Kellerer
    Medizinische Klinik und Poliklinik, Abt. Innere IV, , Germany
    Horm Metab Res 28:737-43. 1996
    ..TNF-alpha and leptin, which are overproduced in fat tissue of obese insulin resistant animal models and in obese humans, might mediate such an inhibitory effect on ..
  67. ncbi Secretion of major adrenal androgens following ACTH administration in obese women with different body fat distribution
    V Vicennati
    Department of Internal Medicine and Gastroenterology, S. Orsola Hospital, University of Bologna, Italy
    Horm Metab Res 30:133-6. 1998
    ..We then investigated the relationships between basal and stimulated androgen levels, body weight and fat distribution and fasting and stimulated insulin levels...
  68. ncbi Effects of swim training on body weight, carbohydrate metabolism, lipid and lipoprotein profile
    H Tanaka
    Exercise Science Unit, University of Tennessee-Knoxville, Knoxville, TN 37996-2700, USA
    Clin Physiol 17:347-59. 1997
    ..Body mass, body fat percentage (36 +/- 2% vs...
  69. ncbi Exercise training down-regulates ob gene expression in the genetically obese SHHF/Mcc-fa(cp) rat
    J E Friedman
    Department of Nutrition, Case Western Reserve University School of Medicine, Cleveland, OH 44106-4935, USA
    Horm Metab Res 29:214-9. 1997
    ..5 hr/day. After endurance training, exercised rats had significantly lower total body fat compared to sedentary rats of the same age, despite maintaining the same body weight...
  70. ncbi Characterization of obese women with reduced sex hormone-binding globulin concentrations
    R Pasquali
    Istituto di Clinica Medica e Gastroenterologia, S. Orsola Hospital, University Alma Mater, Bologna, Italy
    Horm Metab Res 22:303-6. 1990
    ..Both LSO and NSO had similar body mass index and percentage body fat, but the waist to hip girth ratio (WHR), an index of body fat distribution, was significantly higher in LSO (0...
  71. ncbi Subcutaneous fat necrosis, hypercalcemia, and prostaglandin E
    H Sharata
    Department of Medicine, University of Wisconsin-Madison 53705, USA
    Pediatr Dermatol 12:43-7. 1995
    We present two patients with subcutaneous fat necroses (SCFN) in whom endocrinologic studies revealed an association with elevated prostaglandin E (PGE) levels...
  72. ncbi Structure and function of macroencapsulated human and rodent pancreatic islets transplanted into nude mice
    A Andersson
    Department of Medical Cell Biology, Uppsala University, Sweden
    Horm Metab Res 28:306-9. 1996
    ..In a first series of experiments macroencapsulated human islets were implanted into the epididymal fat pad of athymic, nude mice concomitant to an injection from the same batch of islets under the kidney capsule...
  73. ncbi Postprandial hyperlipidemia after a fat loading test in minority adolescents with type 2 diabetes mellitus and obesity
    Vatcharapan Umpaichitra
    Pediatric Endocrinology, Department of Pediatrics, State University of New York Health Science Center at Brooklyn, Brooklyn, NY, USA
    J Pediatr Endocrinol Metab 17:853-64. 2004
    ..We therefore studied lipids, insulin, C-peptide, and glucose in response to an oral fat load simulating the fat content of a high-fat, fast-food meal in 12 type 2 diabetic obese, 15 non-diabetic obese, ..
  74. ncbi The influence of ovariectomy on ob gene expression in rats
    N Yoneda
    Department of Obstetrics and Gynecology, School of Medicine, The University of Tokushima, Japan
    Horm Metab Res 30:263-5. 1998
    ..Furthermore, the expression levels of ob mRNA obtained from the bilateral perimetric fat pads were estimated by Northern blot analysis...
  75. ncbi Angiomyolipoma of the liver: case report
    K F Sung
    Department of Hepato-Gastroenterology, Chang Gung Memorial Hospital, Taipei, Taiwan
    Chang Gung Med J 24:318-23. 2001
    ..The histopathology showed many mature fat cells intermingled with thick-walled blood vessels, and epithelioid cells with eosinophilic cytoplasm; the ..
  76. ncbi Total body dual X-ray absorptiometry is a good measure of both fat mass and fat-free mass in liver cirrhosis compared to "gold-standard" techniques. Melbourne Liver Group
    B J Strauss
    Body Composition Laboratory, Monash Medical Centre, Victoria, Australia
    Ann N Y Acad Sci 904:55-62. 2000
    ..A variety of body composition techniques were used to identify which commonly available ones could best assess both fat-free mass and fat mass relative to a criterion "gold-standard" method available in a specialist laboratory...
  77. doi The differences between venous air embolism and fat embolism in routine intraoperative monitoring methods, transesophageal echocardiography, and fatal volume in pigs
    Ai zhong Wang
    Department of Anesthesiology, Shanghai JiaoTong University Affiliated Sixth People s Hospital, Shanghai, China
    J Trauma 65:416-23. 2008
    Venous air embolism (VAE) or fat embolism (FE) may occur in similar clinical settings such as after multiple injuries or total hip replacement...
  78. doi Foods with a high fat quality are essential for healthy diets
    H Zevenbergen
    Unilever Research and Development, Vlaardingen, The Netherlands
    Ann Nutr Metab 54:15-24. 2009
    b>Fat is generally a highly valued element of the diet to provide energy, palatability to dry foods or to serve as a cooking medium. However, some foods rich in fat have a low fat quality with respect to nutrition, i.e...
  79. ncbi Lipoprotein lipase activity and its relationship to high milk fat transfer during lactation in grey seals
    S J Iverson
    Canadian Institute of Fisheries Technology, Technical University of Nova Scotia, Halifax, Canada
    J Comp Physiol B 165:384-95. 1995
    ..is critical for the uptake and secretion of the long-chain fatty acids in milk and for the assimilation of a high-fat milk diet by suckling young...
  80. ncbi Persistent organochlorine pesticide levels in bovine fat from Mexico
    S M Waliszewski
    Institute of Forensic Medicine, University of Veracruz, SS Juan Pablo II s n, 94290 Boca del Rio, Veracruz, Mexico
    Food Addit Contam 21:774-80. 2004
    ..In the body, they circulate throughout all compartments and accumulate in adipose fat. The aim was to monitor the organochlorine pesticide levels in bovine muscle fat and kidney fat from cows living in ..
  81. ncbi Controlling obesity: what should be changed?
    G Varela-Moreiras
    Departamento de Nutricion, Bromatologia y Tecnologia de los Alimentos, Facultad de Farmacia, Universidad San Pablo CEU Madrid, Spain
    Int J Vitam Nutr Res 76:262-8. 2006
    ..They also provide essential fatty acids and fat soluble vitamins...
  82. ncbi Relationships between plasma leptin levels and body composition parameters measured by different methods in postmenopausal women
    Toivo Jurimae
    Chair of Sport Pedagogy, Faculty of Exercise and Sport Sciences, University of Tartu, Tartu 50090, Estonia
    Am J Hum Biol 15:628-36. 2003
    ..It was hypothesized that the relationship between plasma leptin concentration and body fat is higher using more sophisticated laboratory methods (dual energy X-ray absorptiometry, DXA) in comparison with ..
  83. pmc Developmental origins of disease and determinants of chromatin structure: maternal diet modifies the primate fetal epigenome
    Kjersti M Aagaard-Tillery
    Division of Maternal Fetal Medicine, Department of Obstetrics and Gynecology, University of Utah Health Sciences, Salt Lake City 84158 Utah, USA
    J Mol Endocrinol 41:91-102. 2008
    ..We hypothesized that a maternal high-fat diet would alter the epigenomic profile of the developing offspring, which would result in alterations in fetal ..
  84. ncbi Different quantities and quality of fat in milk products given to young children: effects on long chain polyunsaturated fatty acids and trans fatty acids in plasma
    J C E Svahn
    Department of Pediatrics, Lund University, University Hospital, Malmo, Sweden
    Acta Paediatr 91:20-9. 2002
    ..Thirty-seven 1-y-old children were randomly assigned to one of four feeding groups: (1) low-fat milk (LF) (1.0 g cow's milk fat/dL); (2) standard-fat milk (SF) (3...
  85. ncbi Effects of postmenopausal hormone replacement therapy on body fat composition
    Hasan Yuksel
    Department of Obstetrics and Gynecology, Adnan Menderes University, Faculty of Medicine, 09100 Aydin, Turkey
    Gynecol Endocrinol 23:99-104. 2007
    ..the effects of different types, regimens and administration routes of hormone replacement therapy (HRT) on body fat composition indices in postmenopausal women at increased risk of anthropometry-related cardiovascular disease (CVD).
  86. doi High fat diet containing cholesterol induce aortic aneurysm through recruitment and proliferation of circulating agranulocytes in apoE knock out mice model
    K Gopal
    Centre for Cellular and Molecular Biology, Animal House, Uppal Road, Hyderabad 500 007, India
    J Thromb Thrombolysis 30:154-63. 2010
    We studied and compared the efficiency of induction aneurysm in apo E mice by using high fat diet and Ang II. Aneurysm induced in 6 week old male apo E -/- mice by subcutaneous release of Ang II injection for 45 days...
  87. ncbi Baseline fat-related dietary behaviors of white, Hispanic, and black participants in a cholesterol screening and education project in New England
    Kim M Gans
    Institute for Community Health Promotion, Brown University, I Hoppin Street, Providence, RI 02903, USA
    J Am Diet Assoc 103:699-706; discussion 706. 2003
    To examine baseline fat-related dietary behaviors of white, Hispanic, and black participants in Minimal Contact Education for Cholesterol Change, a National Institutes for Health-funded cholesterol screening and education project ..
  88. ncbi Evaluating the conjugated linoleic acid and trans 18:1 isomers in milk fat of dairy cows fed increasing amounts of sunflower oil and a constant level of fish oil
    C Cruz-Hernandez
    Department of Agricultural, Food and Nutritional Science, University of Alberta, Alberta, 4 10 Agriculture Forestry Centre, Edmonton, Alberta, Canada, T6G 2P5
    J Dairy Sci 90:3786-801. 2007
    ..oil (SFO) in dairy rations to increase vaccenic (trans-11-18:1) and rumenic acids (cis-9,trans-11-18:2) in milk fat, and assess the content and composition of other trans-octadecenoic (trans-18:1) and conjugated linoleic acids (CLA)..
  89. ncbi Effects of supplemental fat source on nutrient digestion and ruminal fermentation in steers
    S P Montgomery
    Department of Animal Sciences and Industry, Kansas State University, Manhattan 66506 1600, USA
    J Anim Sci 86:640-50. 2008
    ..and ileal cannulas were used in a 5 x 5 Latin square design experiment to determine the effects of supplemental fat source on site and extent of nutrient digestion and ruminal fermentation...
  90. doi Performance and metabolic and endocrine changes with emphasis on glucose metabolism in high-yielding dairy cows with high and low fat content in liver after calving
    H M Hammon
    Research Institute for the Biology of Farm Animals FBN, Dummerstorf, Germany
    J Dairy Sci 92:1554-66. 2009
    Elevated liver fat content occurs in high-yielding dairy cows during the transition from pregnancy to lactation after fat mobilization and may affect hepatic glucose metabolism, but the degree of liver fat storage is highly variable...
  91. doi Metabolism and lactation performance in dairy cows fed a diet containing rumen-protected fat during the last twelve weeks of gestation
    K Duske
    Research Institute for the Biology of Farm Animals FBN, 18196 Dummerstorf, Germany
    J Dairy Sci 92:1670-84. 2009
    Effects of dietary fat supplementation prepartum on liver lipids and metabolism in dairy cows are contradictory...
  92. doi Correlation of fat distribution in whole body MRI with generally used anthropometric data
    Burkhard Ludescher
    Section on Experimental Radiology, Department of Diagnostic and Interventional Radiology, University Hospital Tuebingen, Tuebingen, Germany
    Invest Radiol 44:712-9. 2009
    ..Aim of this study was to compare the whole body fat distribution, and the volume of different adipose tissue compartments respectively, with anthropometric data.
  93. pmc Effects of an oral ghrelin mimetic on body composition and clinical outcomes in healthy older adults: a randomized trial
    Ralf Nass
    University of Virginia, Charlottesville, Virginia 22908, USA
    Ann Intern Med 149:601-11. 2008
    ..The decline of growth hormone in the development of sarcopenia is one of many factors, and its etiologic role needs to be demonstrated...
  94. ncbi Embryonic fat-cell lineage in Drosophila melanogaster
    D K Hoshizaki
    Department of Biochemistry, University of Illinois, College of Medicine at Chicago 60612
    Development 120:2489-99. 1994
    The Drosophila adipose tissue, or fat body, and the bodywall muscle are two major tissues derived from the mesoderm. Although much is known about the lineage of muscle cells, little is known about the development of the fat body...
  95. ncbi Prediction of DXA-determined whole body fat from skinfolds: importance of including skinfolds from the thigh and calf in young, healthy men and women
    R G Eston
    Children s Health and Exercise Research Centre, School of Sport and Health Sciences, University of Exeter, UK
    Eur J Clin Nutr 59:695-702. 2005
    To investigate the relationship of percent body fat (%fat), assessed by dual energy-X-ray absorptiometry (DXA) or a four-compartment model, with upper body and lower limb skinfolds.
  96. ncbi Assessment of nutritional status in adult patients with cystic fibrosis: whole-body bioimpedance vs body mass index, skinfolds, and leg-to-leg bioimpedance
    Francis M Hollander
    University Medical Center Utrecht, 3508 GA Utrecht, The Netherlands
    J Am Diet Assoc 105:549-55. 2005
    To investigate whether body mass index (BMI) or body fat percentage estimated from BMI, skinfolds, or leg-to-leg bioimpedance are good indicators of nutritional status in adult patients with cystic fibrosis...
  97. doi Effects of sodium chloride and fat supplementation on finishing steers exposed to hot and cold conditions
    J B Gaughan
    School of Animal Studies, The University of Queensland, Gatton, Australia
    J Anim Sci 87:612-21. 2009
    Three studies were conducted to evaluate the effects of supplemental fat and salt (sodium chloride) on DMI, daily water intake (DWI), body temperature, and respiration rate (RR) in Bos taurus beef cattle. In Exp...
  98. pmc Comparison of air displacement plethysmography to hydrostatic weighing for estimating total body density in children
    Geo Claros
    Department of Health and Exercise Science, University of Oklahoma, Norman, OK, USA
    BMC Pediatr 5:37. 2005
    The purpose of this study was to examine the accuracy of total body density and percent body fat (% fat) using air displacement plethysmography (ADP) and hydrostatic weighing (HW) in children.
  99. ncbi Determination of fat in olestra-containing savory snack products by capillary gas chromatography
    D Schul
    Procter and Gamble Co, Winton Hill Technical Center, Cincinnati, OH 45224, USA
    J AOAC Int 81:848-68. 1998
    A quantitative method to determine fat in olestra-containing savory snack products was validated within the AOAC Peer-Verified Methods Program. The method may be used to demonstrate compliance with the guidelines of the U.S...
  100. ncbi Clinical implications of epidural fat in the spinal canal. A scanning electron microscopic study
    M A Reina
    Department of Anesthesiology, Hospital Universitario Madrid Montepríncipe, Facultad de Medicina, Universidad San Pablo CEU, Madrid, Spain
    Acta Anaesthesiol Belg 60:7-17. 2009
    This review of articles summarizes recent developments in relation to fat located in the epidural space and also in dural sleeves of spinal nerve roots in order to improve our understanding of the clinical effects of the epidural blockade.
  101. ncbi The degree of saturation of fatty acids influences post-ingestive satiety
    C L Lawton
    BioPsychology Group, School of Psychology, University of Leeds, UK
    Br J Nutr 83:473-82. 2000
    ..68 MJ for males; 3.97 MJ for females), high-fat (55% energy) lunch meal...

Research Grants131 found, 100 shown here

  1. Fatty acid Control Obesity and the Metabolic Syndrome via TPR proteins
    Terry D Hinds; Fiscal Year: 2010
    ..Strikingly, our FKBP52 heterozygous mice, when fed a high fat diet, acquire symptoms similar to the Metabolic Syndrome;in which they develop hyperglycemia, hyperlipidemia, ..
  2. Endoplasmic Reticulum Chaperone as a Regulator of Obesity and Diabetes
    Amy S Lee; Fiscal Year: 2010
    ..Serendipitously, we discovered that the Grp78 mice in the C57BL/6 background exhibit resistance to high-fat diet (HFD)-induced obesity and improved insulin sensitivity...
  3. NKT cells, fatty acids, and insulin resistance
    CURTIS LEE GABRIEL; Fiscal Year: 2010
    ..To achieve this goal, we will feed mice a lard diet, a fish oil diet or a low-fat diet, and will analyze NKT cells using flow cytometry, ELISA and ex vivo stimulation assays...
  4. A Prospective Study of Adiposity and Subclinical Coronary Artery Disease
    CHRISTINA LYNN WASSEL; Fiscal Year: 2010
    ..indicate that other measures of body composition, including lean muscle and intermuscular, liver and pericardial fat, are correlated with adipocytokines and atherosclerotic cardiovascular disease (CVD)...
  5. Effects of resistant starch on lipid and glucose metabolism in insulin resistance
    RONALD M contact KRAUSS; Fiscal Year: 2010
    ..Current dietary guidelines emphasize substitution of carbohydrate calories for total and saturated fat calories for prevention and management of chronic disease...
  6. Effect of Perinatal Diet on Developmental Programming of the Skeleton
    Mary L Bouxsein; Fiscal Year: 2010
    ..Perinatal diet is of particular interest because maternal caloric restriction (CR) and high fat (HF) diet have each been shown to trigger developmental programming that increases the risk of metabolic disease, ..
  7. Chronic stress mediates fat-related changes in insulin signaling and gut motility
    CHARALABOS contact POTHOULAKIS; Fiscal Year: 2010
    ..Furthermore, changes in body fat observed in obesity, or changes in body mass index (as observed in patients suffering from functional ..
  8. SH2-B regulation of body weight and energy homeostasis
    Liangyou Rui; Fiscal Year: 2010
    ..Leptin, which is produced by adipose tissue and secreted into the bloodstream in proportion to the total fat mass, binds to and activates its receptor in the hypothalamus, relaying peripheral nutritional signals to the ..
  9. PD2024: A Peripherally Active TNFalpha inhibitor for the treatment of Obesity
    ..of our lead TNF1 inhibitor on food intake, body weight, energy expenditure, circadian activity, and total body fat/lean body mass in high-fat diet-induced obese rats and lean rats fed standard low-fat lab chow...
  10. Metabolic Consequences of Neonatal Programming by a GLP1 Receptor Agonist
    DANIELLA ANGELA BABU; Fiscal Year: 2011
    ..Further, our preliminary data demonstrate that the effect of neonatal Ex-4 on body weight and fat mass is conserved in C57BI6 mice...
  11. Effects of Recombinant IGF-I in HIV Associated Metabolic Disease
    Roy J Kim; Fiscal Year: 2011
    ..the use of these medications is associated with development of a syndrome consisting of abnormal changes in fat distribution, dyslipidemia, and abnormal glucose homeostasis...
  12. Role of the transcriptional coregulator, TRIP Br2, in adipocyte metabolism
    Chong Wee Liew; Fiscal Year: 2011
    ..These studies will determine the mechanisms contributing to high fat diet-induced obesity resistance in our mouse model...
  13. Quantification of Brown Adipose Tissue by MRI in Children and Teenagers
    Vicente Gilsanz; Fiscal Year: 2011
    DESCRIPTION (provided by applicant): The objective of this proposal is to develop and validate chemical-shift fat-water MRI methods for the detection and quantification of both metabolically active and inactive brown adipose tissue (BAT)..
  14. Role of SCD1 and Dietary Methionine Restriction on Energy Homeostasis
    ERIC PAUL PLAISANCE; Fiscal Year: 2011
    ..SCD1 has been shown to increase the synthesis and secretion of triglycerides following a high-saturated fat or high-carbohydrate diet...
  15. Pyruvate Dehydrogenase kinase as Therapeutic Target for Hepatic Steatosis, Obesit
    Robert A Harris; Fiscal Year: 2012
    ..Second, PDK knock out mice maintained on a high-fat, diabetogenic diet accumulate less fat in their livers, are less obese, and have lower blood glucose levels, better ..
  16. Pharmacogenetics of obesity and endocannabinergic modulation (POEM)
    Russell A Wilke; Fiscal Year: 2012
    ..of obesity) or WHR (as a measure of abdominal obesity) will be further tested for association with total body fat by DEXA scan (as a confirmatory measure of global obesity) and the ratio of visceral fat / subcutaneous fat by CT ..
  17. Ashraf Gorgey; Fiscal Year: 2016
    ..Within few weeks of injury, there are significant decrease in whole body fat-free mass (FFM), particularly lower extremity skeletal muscle mass and subsequent increase in fat mass (FM)...
    Samuel Klein; Fiscal Year: 2012
    ..It is not known why weight gain and body fat accumulation causes metabolic abnormalities in some obese persons but not in others...
  19. Noninvasive Measurement of UCP1 in Brown Adipose Tissue
    Joel K Yisraeli; Fiscal Year: 2012
    ..There are at least two clearly distinguishable forms of fat: white adipose tissue (WAT), which stores energy, and brown adipose tissue (BAT), which burns energy for ..
  20. Brain-derived neurotrophic factor induced weight loss: neural mechanisms
    Chuanfeng Wang; Fiscal Year: 2012
    ..to its receptor TrkB;2) BDNF effects on energy balance are mediated by CRHR signaling pathway;3) BDNF prevents high fat diet (HFD) induced obesity;and 4) Chronic BDNF induces proliferation of newborn neurons that impact energy ..
  21. BMP7 and the regulation of central and peripheral energy balance
    Kristy Townsend; Fiscal Year: 2012
    ..Thus far, we have found that mice with BMP7 haploinsufficiency (BMP7-/+) on a high fat diet (HFD) are more obese and hyperphagic than littermate controls, with decreased energy expenditure (oxygen ..
    Clinton T Rubin; Fiscal Year: 2012
    ..In an unexpected finding, these signals also suppress adipogenesis, with 29% less total visceral abdominal fat in mice subject to 12w of LMMS...
  23. Mechanisms by which the protein kinase IKKi regulates energy expenditure
    JONATHAN CARL MOWERS; Fiscal Year: 2012
    ..IKKi expression and activity are dramatically increased in mice on a high fat diet in both liver and white adipose tissue...
  24. Remodeling of Lipid Metabolism by Dietary Methionine Restriction
    ERIC PAUL PLAISANCE; Fiscal Year: 2012
    ..characterized by a cluster of pathologies that includes obesity and impaired regulation of carbohydrate and fat metabolism...
  25. Susan S Smyth; Fiscal Year: 2014
    ..at promoting energy expenditure by increasing brown adipose tissue (BAT) content or activity in adults could reduce fat deposition and obesity...
  26. Is HIV-associated lipodystrophy a risk factor for cirrhosis of the liver?
    George Ioannou; Fiscal Year: 2013
    ..Insulin resistance and increased intra-abdominal fat are also the major predisposing conditions of nonalcoholic fatty liver disease (NAFLD) and nonalcoholic ..
  27. Regulation of energy homeostasis and adiposity by a Golgi-associated PARP enzyme
    Nai Wen Chi; Fiscal Year: 2013
    ..owing to increased energy expenditure, are protected from obesity and lipotoxicity when challenged with a high fat diet. Aim 3 will investigate the adipose-specific roles of TNKS in adiponectin secretion and energy homeostasis...
  28. Nicotinamide N-methyltransferase (NNMT) in obesity and insulin resistance
    Qin Yang; Fiscal Year: 2013
    ..Knockdown of NNMT with antisense oligonucleotides (ASO) in adipose tissue and liver of mice fed a high fat diet induces expression of spermine/spermidine acetyltransferase (SSAT), a key enzyme regulating polyamine flux in ..
  29. Effects of gastric bypass on the gut microbiota and energy balance
    Alice Liou; Fiscal Year: 2012
    ..are heavily influenced by diet and have recently been implicated as powerful regulators of obesity-associated fat deposition, decreased energy expenditure, and insulin resistance...
  30. Scott B Going; Fiscal Year: 2016
    ..The proposed project is designed to clarify the relationship of obesity, fat distribution (visceral adipose tissue and tigh muscle fat content), insulin resistance (HOMA-IR) and inflammation (..
  31. David E Harrison; Fiscal Year: 2014
    ..The following will be determined: body composition and subcutaneous/visceral fat tissue distribution (using computerized tomography imaging);circulating adipokines (adiponectin, resistin, IL-6, ..
  32. Genetic Determinants of Visceral Adiposity
    Yongmei Liu; Fiscal Year: 2013
    ..the proposed study provides a unique opportunity to discover genes (and their variants) involved in visceral fat accumulation and may provide novel insights into the pathophysiology, prevention and promising therapeutic targets ..
  33. Andrew B Muir; Fiscal Year: 2014
    ..Studies, mainly in rodents show that maternal ingestion of a high fat, high sugar, high calorie diet (HCD) during pregnancy and lactation programs behaviors and metabolism that promote ..
  34. Jianhua Shao; Fiscal Year: 2016
    ..By using high fat diet-induced obese dams and adiponectin knockout mice, Specific Aim 3 will study the effects of maternal obesity ..
  35. David G Harrison; Fiscal Year: 2015
    ..vascular ROS production develop exaggerated obesity and insulin resistance/metabolic syndrome when fed high-fat diet. Scavenging of ROS attenuated weight gain in these mice...
  36. Huaizhu Wu; Fiscal Year: 2016
    ..Our preliminary data show that: (1) obesity with insulin resistance induced by high-fat (HF) diet rich in saturated FAs up-regulates CD11c on blood monocytes and AT macrophages;(2) CD11c contributes to ..
  37. The Impact of Heat Shock Protein Expression on Inflammation and Insulin Action
    Andrea L Hevener; Fiscal Year: 2013
    ..genetic overexpression of HSP72 will protect against inflammation, insulin resistance, and obesity induced by high fat diet (HFD) or leptin deficiency...
  38. Vitamin D Effect on Body Composition During Behavioral Weight Loss in Women
    ANNE M MCTIERNAN; Fiscal Year: 2013
    ..Likewise, whether vitamin D level influences fat, muscle, and bone mass in individuals undergoing weight loss through diet and exercise is unclear...
  39. David A Bernlohr; Fiscal Year: 2016
    ..When placed on high fat diets, FABP knockout mice exhibit attenuated characteristics of the metabolic syndrome including diminished ..
  40. LINDA ANNE BARBOUR; Fiscal Year: 2014
    ..Although frank hyperglycemia from gestational diabetes (GDM) is recognized as a major fuel source affecting fetal fat accretion, the alarming increase in the number of large for gestational age (LGA) infants are being born primarily ..
  41. HEIKE MUENZBERG-GRUENING; Fiscal Year: 2016
    ..g. muscle and white fat) are investigated for leptin induced changes (e.g fat oxidation, mitogenesis)...
  42. Amy Johnson; Fiscal Year: 2015
    ..immune system infiltrate adipose tissue at the onset of weight gain contributing to the inflammatory state of fat, ultimately resulting in systemic insulin resistance, while alternatively activated, anti-inflammatory M2 ..
  43. Keiko Watanabe; Fiscal Year: 2015
    ..rats, we demonstrated that periodontitis accelerates the development of insulin resistance (IR) and T2DM in high fat (HF), but not low fat fed animals...
  44. Stefan A Czerwinski; Fiscal Year: 2014
    ..Recent studies have demonstrated potential mechanistic links between visceral fat accumulation and increased deposition of fat in the liver...
  45. Bette J Caan; Fiscal Year: 2016
    ..Though overweight persons tend to have both higher amounts of lean and fat mass, low levels of muscle mass may be present in overweight or obese people;sarcopenia (muscle wasting) is common ..
  46. Metabolic Actions of Omega-3 Fatty Acids on Inflammation
    Michael Miller; Fiscal Year: 2013
    ..subjects and did not measure effects on adipocyte lipolysis, adipokine secretion, lipogenesis or visceral fat. We hypothesize that EPA/DHA supplementation will not only reduce plasma TG, but also decrease systemic and tissue ..
  47. Maternal Overweight: Consequences for Insulin Signaling in the Offspring
    Kartik Shankar; Fiscal Year: 2013
    ..objective is to investigate interactions in the offspring, between an obesegenic environment (consumption of a high-fat diet, HFD) and prior exposure to maternal OW during gestation...
  48. GUANG WILLIAM WONG; Fiscal Year: 2016
    ..Transgenic (Tg) mice with elevated circulating CTRP9 are significantly leaner due to reduced fat mass...
  49. Oleg Varlamov; Fiscal Year: 2014
    ..Studies in prostate cancer patients also demonstrated that intensive lifestyle changes, including a low-fat diet (LFD), can slow the progression of prostate cancer, but the benefits of a diet restriction for reducing MS and ..
  50. The Role of H6PDH and 11beta-HSD1 in Type 2 Diabetes and Obesity
    Yanjun Liu; Fiscal Year: 2013
    ..hepatic and adipose 112-HSD1 activity that may contribution to insulin sensitivity and weight loss in a high- fat diet model of obesity...
  51. Pamela U Freda; Fiscal Year: 2014
    ..ongoing prospective acromegaly cohort study to characterize novel features of acromegaly including an abnormal fat distribution that may contribute significantly to its increased morbidity and mortality...
  52. Muscle, Fat and NK Lymphocytes in Aging
    Charles T Lutz; Fiscal Year: 2013
    ..Skeletal muscle and fat are known to regulate each other via cytokines, including adipose-derived tumor necrosis factor (TNF) and IL-6, ..
  53. Calorie Restriction &Body Composition, Function, &QoL in Older Adults
    Julie L Locher; Fiscal Year: 2013
    ..If visceral fat is a key factor that increases risk in obese older adults, do weight reducing diets that decrease total fat mass as ..
  54. Anna Eisenstein; Fiscal Year: 2015
    ..Furthermore, administration of a high fat, high cholesterol diet (HFD) vastly upregulates the expression of the A2b adenosine receptor (A2bAR), and A2bAR KO ..
  55. Effects of amino acids on regional lipid metabolism
    Elisabet Borsheim; Fiscal Year: 2013
    ..PUBLIC HEALTH RELEVANCE: Elevated fat level in blood is a risk factor for coronary heart disease, a major cause of death in America...
  56. Group X sPLA2: Regulator of lipolysis and glucose homeostasis
    Nancy R Webb; Fiscal Year: 2013
    ..While the close relationship between obesity and diabetes has long been recognized, understanding how an expanded fat mass results in the progressive development of insulin resistance and type 2 diabetes has proven difficult...
  57. Ajay Chawla; Fiscal Year: 2016
    ..Moreover, the recent discovery of brown adipose tissue in humans suggests that activation of brown fat might be useful in the treatment of human obesity...
  58. ALEXANDER BANKS; Fiscal Year: 2014
    ..Phosphorylation of PPAR-gamma at serine 273 occurs shortly after the onset of high fat diet feeding and increases with progressive obesity...
    MICHAEL ISAAC GORAN; Fiscal Year: 2013
    ..several years, and this was associated with a 32% lower beta-cell function, and an accelerated gain in visceral fat over time...
  60. Kerri M Winters-Stone; Fiscal Year: 2014
    ..that active participation in whole-body vibration (WBV) training will result in suppression of accumulation of fat, maintenance of lean muscle mass and reduced levels of risk factors as- sociated with obesity...
  61. JOSHUA ROBERT COOK; Fiscal Year: 2015
    ..I will therefore perform the temperature exposure experiments again following high- fat feeding of A-FoxO1 and WT mice and determine whether A-FoxO1 mice differ significantly in their sensitivity to ..
  62. Sihem Boudina; Fiscal Year: 2016
    ..The adipocyte- specific MnSOD KO (AdSod2KO) mice are lean, have increased whole body fat oxidation and resist diet-induced glucose intolerance, insulin resistance and hepatic steatosis...
  63. Response to and signals of caloric restriction and intermittent feeding regimens
    MARC KOPEL HELLERSTEIN; Fiscal Year: 2010
    ..include global cell proliferation (mammary, prostate, skin, liver, lymphocytes), adipose tissue dynamics and fat distribution, insulin sensitivity, and vascular smooth muscle cell proliferation...
  64. IL-15, Body Compositition and Insulin Sensivity in Aging
    LeBris S Quinn; Fiscal Year: 2010
    ..muscle mass (termed sarcopenia), as well as by increases in white adipose tissue mass, resulting in an increased fat:lean body composition ratio...
  65. Physiological role of PRDM16 in brown fat development and energy balance
    Patrick Seale; Fiscal Year: 2011
    Aim 1: We test the hypothesis that PRDM16 can drive the formation of functional brown adipocytes in white fat depots of mice to raise energy expenditure and protect against obesity and cold exposure. Diet-Induced Obesity (DIP)...
  66. Sogol Mostoufi-Moab; Fiscal Year: 2016
    ..Despite completion of therapy years prior, these recipients had markedly increased whole body fat mass, decreased lean mass, and substantial deficits in trabecular BMD and cortical dimensions compared with >650 ..
  67. Insulin and CNS Contol of Body Weight and Food Intake
    Stephen C Woods; Fiscal Year: 2013
    ..Since most stored energy is in the form of adipose tissue (fat), and since the brain is the major controller of energy homeostasis, a fundamental requirement is that the brain ..
  68. The AMP-activated protein kinase (AMPK) antagonizes inflammation through SIRT1
    Hang Shi; Fiscal Year: 2012
    ..macrophages, and will characterize the inflammatory status and insulin sensitivity in these mice fed a high-fat diet or infused with lipids...
  69. TPL2: A Central Node in Obesity-Associated Inflammation and Metabolic Disorders
    Andrew S Greenberg; Fiscal Year: 2010
    ..Preliminary Studies demonstrate that relative to wild-type (WT) mice, TPL2 knockout (TPLKO) mice fed a high fat diet (HFD) were substantially protected from 1) macrophage-mediated adipose tissue inflammation, 2) adipose and ..
  70. Beta-adrenergic regulation of adipose tissue function by PKA and MAP kinases
    Sheila Collins; Fiscal Year: 2009
    ..metabolism to control (i) lipolysis for mobilization of stored energy and (ii) adaptive thermogenesis in brown fat. All 3 known [unreadable]AR subtypes are expressed in adipocytes, and [unreadable]ARs are coupled to increases in ..
  71. Christopher D Gardner; Fiscal Year: 2016
    ..with SNPs from three genes (FABP2, PPARG, and ADRB2): a low carbohydrate-responsive genotype (LCG) and a low fat-responsive genotype (LFG)...
  72. Brown Adipose Tissue Quantification Using Magnetic Resonance Imaging
    E Brian Welch; Fiscal Year: 2013
    ..To achieve these goals, we will pursue the following specific aims: [1] Develop and optimize MRI measurements of fat signal fraction (FSF), water longitudinal magnetization relaxation rate (T1_H2O), water apparent diffusion ..
  73. LAUREN ASHLEY COWART; Fiscal Year: 2016
    ..Moreover, we found that ablation of SK1 attenuated high-fat diet-induced immune cell infiltrate in adipose tissue...
  74. Liqing Yu; Fiscal Year: 2014
    ..genetic inactivation or ezetimibe inhibition of NPC1L1 in mice was recently found to protect against high fat diet (HFD)-induced obesity (DIO) and associated metabolic disorders...
  75. Devendra K Agrawal; Fiscal Year: 2016
    ..We hypothesize that obesity-induced inflammatory phenotype of epicardial fat is exacerbated by vitamin D deficiency leading to endothelial dysfunction and enhanced intimal hyperplasia ..
  76. Effects of High Fat Diet and Environmental Obesogen Co-Exposure on Osteoporosis
    Jennifer J Schlezinger; Fiscal Year: 2013
    ..A newly recognized risk factor is a high fat diet and obesity...
  77. ELVIRA MARIE ISGANAITIS; Fiscal Year: 2015
    ..Altered body composition with increased fat mass is a key contributor to these risks, yet accelerated postnatal adipose tissue growth following prenatal ..
  78. Allison W Xu; Fiscal Year: 2016
    ..by applicant): Leptin is an adipocyte-derived hormone that circulates at levels proportional to the body's fat mass, which conveys the abundance of peripheral energy stores to the brain...
  79. Shingo Kajimura; Fiscal Year: 2016
    ..anti- obesity medications act to repress energy intake, either by suppressing appetite or by inhibiting intestinal fat absorption...
  80. SAGAR PRADEEP BAPAT; Fiscal Year: 2014
    ..These fat-resident Tregs (fTregs) may have a role in suppressing inflammation and preventing insulin resistance in the ..
  81. Timothy E Graham; Fiscal Year: 2016
    ..g., liver, muscle, and fat)...
  82. Analia Loria; Fiscal Year: 2015
    ..to model the growing epidemic of children with extremely poor dietary lifestyles, we exposed the rats to a high fat diet (HFD) as a secondary stressor...
  83. ANDREW JESS DANNENBERG; Fiscal Year: 2015
    ..inflammation, elevated COX-2 expression and increased aromatase levels occur in both the MG and visceral fat (VF) in mouse models of obesity...
  84. Rachana Shah; Fiscal Year: 2015
    ..models to decrease adipocyte and monocyte inflammation and prevent adipose leukocyte infiltration during high-fat feeding;in vivo human data, however, is lacking...
  85. Dympna Gallagher; Fiscal Year: 2015
    ..over a long period of time thereby allowing for an investigation of whether adaptations of organ/tissue mass and fat redistribution occur;and REE relative to FFM at T24 continues to be lower compared to pre-surgery levels which is ..
  86. Raghunatha R Yammani; Fiscal Year: 2014
    ..We propose two Specific Aims: Aim 1: To determine if a high-fat diet induces ER stress and the unfolded protein response in joint tissue in vivo...
  87. ERICA LYN STONE; Fiscal Year: 2015
    ..In this application I propose to 1) investigate the role of T cell subsets in high fat diet -induced insuli resistance and glucose intolerance, 2) investigate the homing of T regulatory cells to the ..
  88. Leptin in Human Energy and Neuroendocrine Homeostasis
    Rudolph L Leibel; Fiscal Year: 2013
    ..Our central hypothesis is that the molecular physiology of the regulation of body fat stores is designed to maintain these stores above a minimal level that is determined by genetic and other factors...
  89. Michael D Jensen; Fiscal Year: 2016
    DESCRIPTION (provided by applicant): Regional differences in fat accumulation must develop from imbalances in fatty acid uptake or free fatty acid (FFA) release between fat depots...
  90. ROSARIO G SCALIA; Fiscal Year: 2016
    ..this application demonstrate that nutrients overload causes a postprandial infiltration of neutrophils in visceral fat depots. Obviously, this acute response to dietary nutrients occurs well before weight gain and insulin resistance...
  91. Muthu Periasamy; Fiscal Year: 2016
    ..In addition, when Sln-/- mice when fed on high fat diet (HFD) gained significantly more weight than WT controls, whereas WT mice fed on HFD were less obese but showed ..
  92. MICHAL MATEUSZ MASTERNAK; Fiscal Year: 2014
    The long-term goal of our research is to determine the effects of visceral fat on insulin sensitivity and longevity...
  93. Joshua F Baker; Fiscal Year: 2016
    ..Similarly, low BMI is associated with low lean mass. The applicant demonstrated that low lean mass and greater fat mass are associated with cortical thinning of bone among healthy adults...
  94. Human Brown Adipose Tissue and its Impact on Metabolism
    AARON MARTIN CYPESS; Fiscal Year: 2013
    ..provided by applicant): The adipose tissue pool in mammals comprises at least two functionally different types of fat: white and brown...
  95. Steven A Farber; Fiscal Year: 2016
    ..the dynamic regulatory signals that coordinate absorption and transport of fatty acids (FA), and morphogenesis and fat storage in adipose tissues, remain unclear...
  96. Metabolic Determinants of Cardiac Bioactive Sphingolipids in Lipid Overload
    Sarah Brice Russo; Fiscal Year: 2013
    ..Obesity and the metabolic syndrome are two overlapping conditions in which the body begins to store excess fat in non-adipose cells, including the heart...
  97. Lipocalin 2 in Inflammation and Metabolic Control
    Xiaoli Chen; Fiscal Year: 2013
    ..impaired BAT thermogenic activation by cold exposure and reduced BAT activity and browning of WAT during high fat diet-induced obesity...
  98. Scot R Kimball; Fiscal Year: 2016
    ..Moreover, in preliminary studies, we have found a similar dysregulation in rats fed a high-fat diet enriched in saturated fatty acids...
  99. Feng Liu; Fiscal Year: 2016
    ..Our preliminary studies showed that fat-specific knockout of the Growth factor receptor binding protein-10 (Grb10) in mice substantially increased mTORC1 ..
  100. RANDALL LEE MYNATT; Fiscal Year: 2016
    Considerable evidence supports the idea that oversupply of dietary fat exceeds the storage capacity of adipose tissue and leads to ectopic lipid accumulation resulting in "metabolic stress" in skeletal muscle, liver, pancreas and ..
  101. Dana M Small; Fiscal Year: 2016
    ..Our strategy builds on previous animal studies demonstrating that prolonged exposure to a high-fat diet substantially reduces the intestinal synthesis of appetite-regulating lipid messengers...