FAT1

Summary

Gene Symbol: FAT1
Description: FAT atypical cadherin 1
Alias: CDHF7, CDHR8, FAT, ME5, hFat1, protocadherin Fat 1, FAT tumor suppressor 1, cadherin ME5, cadherin family member 7, cadherin-related family member 8, cadherin-related tumor suppressor homolog, protein fat homolog
Species: human
Products:     FAT1

Top Publications

  1. Dunne J, Hanby A, Poulsom R, Jones T, Sheer D, Chin W, et al. Molecular cloning and tissue expression of FAT, the human homologue of the Drosophila fat gene that is located on chromosome 4q34-q35 and encodes a putative adhesion molecule. Genomics. 1995;30:207-23 pubmed
    b>FAT, a new member of the human cadherin super-family, has been isolated from the T-leukemia cell line J6...
  2. Braun G, Kretzler M, Heider T, Floege J, Holzman L, Kriz W, et al. Differentially spliced isoforms of FAT1 are asymmetrically distributed within migrating cells. J Biol Chem. 2007;282:22823-33 pubmed
    Cadherin FAT1 is localized along the leading edge of mammalian cells and is necessary for polarization and directed migration...
  3. de Bock C, Ardjmand A, Molloy T, Bone S, Johnstone D, Campbell D, et al. The Fat1 cadherin is overexpressed and an independent prognostic factor for survival in paired diagnosis-relapse samples of precursor B-cell acute lymphoblastic leukemia. Leukemia. 2012;26:918-26 pubmed publisher
    ..Previously, the altered expression of Fat1 cadherin has been implicated in a number of solid tumors...
  4. Dikshit B, Irshad K, Madan E, Aggarwal N, Sarkar C, Chandra P, et al. FAT1 acts as an upstream regulator of oncogenic and inflammatory pathways, via PDCD4, in glioma cells. Oncogene. 2013;32:3798-808 pubmed
    ..Here we have studied the FAT1 (Homo sapiens FAT tumor-suppressor homolog 1 (Drosophila)) gene to identify its role in the tumorigenecity of the ..
  5. Tanoue T, Takeichi M. Mammalian Fat1 cadherin regulates actin dynamics and cell-cell contact. J Cell Biol. 2004;165:517-28 pubmed
    ..In this work, we investigated the function of a mammalian Fat cadherin. Fat1 was localized at filopodial tips, lamellipodial edges, and cell-cell boundaries, overlapping with dynamic actin ..
  6. Magg T, Schreiner D, Solis G, Bade E, Hofer H. Processing of the human protocadherin Fat1 and translocation of its cytoplasmic domain to the nucleus. Exp Cell Res. 2005;307:100-8 pubmed
    The giant protein hFat1, a member of the cadherin superfamily, has been proposed to play roles in cerebral development, glomerular slit formation, and also to act as a tumor suppressor, but its mechanisms of action have not been ..
  7. Nakaya K, Yamagata H, Arita N, Nakashiro K, Nose M, Miki T, et al. Identification of homozygous deletions of tumor suppressor gene FAT in oral cancer using CGH-array. Oncogene. 2007;26:5300-8 pubmed
    ..We identified a homozygous loss of FAT (4q35), a new member of the human cadherin superfamily, from genome-wide screening of copy number alterations in ..
  8. Kalveram B, Schmidtke G, Groettrup M. The ubiquitin-like modifier FAT10 interacts with HDAC6 and localizes to aggresomes under proteasome inhibition. J Cell Sci. 2008;121:4079-88 pubmed publisher
  9. Chosdol K, Misra A, Puri S, Srivastava T, Chattopadhyay P, Sarkar C, et al. Frequent loss of heterozygosity and altered expression of the candidate tumor suppressor gene 'FAT' in human astrocytic tumors. BMC Cancer. 2009;9:5 pubmed publisher
    ..Its sequence corresponded with a region of FAT, a putative tumor suppressor gene initially identified in Drosophila...

More Information

Publications132 found, 100 shown here

  1. Hou R, Sibinga N. Atrophin proteins interact with the Fat1 cadherin and regulate migration and orientation in vascular smooth muscle cells. J Biol Chem. 2009;284:6955-65 pubmed publisher
    b>Fat1, an atypical cadherin induced robustly after arterial injury, has significant effects on mammalian vascular smooth muscle cell (VSMC) growth and migration...
  2. Nishikawa Y, Miyazaki T, Nakashiro K, Yamagata H, Isokane M, Goda H, et al. Human FAT1 cadherin controls cell migration and invasion of oral squamous cell carcinoma through the localization of ?-catenin. Oncol Rep. 2011;26:587-92 pubmed publisher
    b>FAT1 [Homo sapiens FAT tumor suppressor homolog 1 (Drosophila)] is an intrinsic membrane protein classified as a member of the cadherin superfamily...
  3. Sadeqzadeh E, de Bock C, Zhang X, Shipman K, Scott N, Song C, et al. Dual processing of FAT1 cadherin protein by human melanoma cells generates distinct protein products. J Biol Chem. 2011;286:28181-91 pubmed publisher
    The giant cadherin FAT1 is one of four vertebrate orthologues of the Drosophila tumor suppressor fat. It engages in several functions, including cell polarity and migration, and in Hippo signaling during development...
  4. Morris L, Kaufman A, Gong Y, Ramaswami D, Walsh L, Turcan S, et al. Recurrent somatic mutation of FAT1 in multiple human cancers leads to aberrant Wnt activation. Nat Genet. 2013;45:253-61 pubmed publisher
    ..Here, we report recurrent somatic mutations of the Drosophila melanogaster tumor suppressor-related gene FAT1 in glioblastoma (20.5%), colorectal cancer (7.7%), and head and neck cancer (6.7%)...
  5. Wang C, Yen J, Cheng Y, Lin C, Hsieh C, Gau R, et al. Polygala tenuifolia extract inhibits lipid accumulation in 3T3-L1 adipocytes and high-fat diet-induced obese mouse model and affects hepatic transcriptome and gut microbiota profiles. Food Nutr Res. 2017;61:1379861 pubmed publisher
    ..We used 3T3-L1 adipocytes and a high-fat diet-induced obese mouse model to determine the effects of PTE on lipid accumulation...
  6. Adil M, Amin S, Arif T. Nicolau's syndrome: A rare but preventable iatrogenic disease. Acta Dermatovenerol Croat. 2017;25:251-253 pubmed
    ..A lipophilic drug may penetrate the vessel and produce physical occlusion like fat embolism. Cytotoxic drugs may produce perivascular inflammation and ischemic necrosis...
  7. Conrad K. G-Protein-coupled receptors as potential drug candidates in preeclampsia: targeting the relaxin/insulin-like family peptide receptor 1 for treatment and prevention. Hum Reprod Update. 2016;22:647-64 pubmed publisher
    ..injured endothelium and improving maternal vascularity in organs such as breast, uterus, pancreas, skin and fat. By exploiting its pleiotropic molecular attributes in preeclampsia, relaxin supplementation is expected to (i) ..
  8. Salas Huetos A, Bullo M, Salas Salvado J. Dietary patterns, foods and nutrients in male fertility parameters and fecundability: a systematic review of observational studies. Hum Reprod Update. 2017;23:371-389 pubmed publisher
    ..Fish, shellfish and seafood, poultry, cereals, vegetables and fruits, low-fat dairy and skimmed milk were positively associated with several sperm quality parameters...
  9. Liu S, Feng L, Jiang W, Liu Y, Jiang J, Wu P, et al. Impact of exogenous lipase supplementation on growth, intestinal function, mucosal immune and physical barrier, and related signaling molecules mRNA expression of young grass carp (Ctenopharyngodon idella). Fish Shellfish Immunol. 2016;55:88-105 pubmed publisher
    ..Meanwhile, in high-fat and low-protein diets, optimal exogenous lipase supplementation improved growth, intestinal growth and function, ..
  10. Vilas Sueiro A, González Vilas D, Aguilera C, Monteagudo B, De Las Heras C. Hardness and Painful Lesion of the Breast. Acta Dermatovenerol Croat. 2017;25:305-306 pubmed
    ..Subcutaneous fat showed a lobular panniculitis with a prominent lymphocytic infiltrate and hyalinization of the fat lobules (hyaline ..
  11. Farrell G, Haczeyni F, Chitturi S. Pathogenesis of NASH: How Metabolic Complications of Overnutrition Favour Lipotoxicity and Pro-Inflammatory Fatty Liver Disease. Adv Exp Med Biol. 2018;1061:19-44 pubmed publisher
    ..The key issue is not the quantity of liver fat but the type(s) of lipid molecules that accumulate, and how they are "packaged" to avoid subcellular injury...
  12. Gil Ã, Martínez de Victoria E, Olza J. Indicators for the evaluation of diet quality. Nutr Hosp. 2015;31 Suppl 3:128-44 pubmed publisher
    ..Nutrients found in many scores are total fat, saturated fatty acids or the ratio of monounsaturated fatty acids to saturated fatty acids or the latter SFA to ..
  13. Traish A. Negative Impact of Testosterone Deficiency and 5?-Reductase Inhibitors Therapy on Metabolic and Sexual Function in Men. Adv Exp Med Biol. 2017;1043:473-526 pubmed publisher
    ..of T deficiency (TD) on a host of physiological functions including reduced lean body mass (LBM), increased fat mass (FM), increased insulin resistance (IR), metabolic syndrome (MetS) and adiposity, reduced bone mineral ..
  14. Schwingshackl L, Hoffmann G, Buijsse B, Mittag T, Stelmach Mardas M, Boeing H, et al. Dietary supplements and risk of cause-specific death, cardiovascular disease, and cancer: a protocol for a systematic review and network meta-analysis of primary prevention trials. Syst Rev. 2015;4:34 pubmed publisher
    ..D, Vitamin E, and multivitamin supplements); fatty acids (omega-3 fatty acids, omega-6 fatty acids, monounsaturated fat); minerals (magnesium, calcium, selenium, potassium, iron, zinc, copper, iodine; multiminerals); supplements ..
  15. Jing Y, Cai D, Chen Q, Xiong Q, Hu T, Yao Y, et al. Liuwei Dihuang soft capsules attenuates endothelial cell apoptosis to prevent atherosclerosis through GPR30-mediated regulation in ovariectomized ApoE-deficient mice. J Ethnopharmacol. 2017;208:185-198 pubmed publisher
    ..All ApoE-/- mice were ovariectomized (Ovx) one week prior to oral administration and initiation of high-fat diet. C57BL/6 mice were given sham operation and maintained on normal diet...
  16. Serhiyenko V, Serhiyenko A. Cardiac autonomic neuropathy: Risk factors, diagnosis and treatment. World J Diabetes. 2018;9:1-24 pubmed publisher
    ..first of all ?-lipoic acid (ALA), aldose reductase inhibitors, acetyl-L-carnitine; vitamins, first of all fat-soluble vitamin B1; correction of vascular endothelial dysfunction; prevention and treatment of thrombosis; in ..
  17. Seven E. Overweight, hypertension and cardiovascular disease: focus on adipocytokines, insulin, weight changes and natriuretic peptides. Dan Med J. 2015;62:B5163 pubmed
    ..Since adjustment for CRP decreased the BMI-associated CVD risk markedly, our data indirectly suggest that IL-6 originating from fat tissue could play a role in overweight and obesity-related cardiovascular disease.
  18. Valenzuela R, Echeverría F, Ortiz M, Rincón Cervera M, Espinosa A, Hernandez Rodas M, et al. Hydroxytyrosol prevents reduction in liver activity of ?-5 and ?-6 desaturases, oxidative stress, and depletion in long chain polyunsaturated fatty acid content in different tissues of high-fat diet fed mice. Lipids Health Dis. 2017;16:64 pubmed publisher
    ..High-fat diet (HFD) decreases the activity of both desaturases and LCPUFA accretion in liver and other tissues...
  19. Lu L, Liu M, Sun R, Zheng Y, Zhang P. Myocardial Infarction: Symptoms and Treatments. Cell Biochem Biophys. 2015;72:865-7 pubmed publisher
    ..The heart attack can be prevented by taking an earlier action to lower those risks by controlling diet, fat, cholesterol, salt, smoking, nicotine, alcohol, drugs, monitoring of blood pressure every week, doing exercise ..
  20. Lee T, Bai K, Chen Y, Lee T, Chung C, Tsai W, et al. Histone deacetylase inhibition of cardiac autophagy in rats on a high?fat diet with low?dose streptozotocin-induced type 2 diabetes mellitus. Mol Med Rep. 2017;: pubmed publisher
    ..end product?specific receptor (RAGE), and proinflammatory cytokines in control rats and in rats treated with a high?fat diet (60% fat) and low?dose streptozotocin (35 mg/kg) in order to induce T2DM, with or without an HDAC inhibitor (..
  21. Wang T, He C. Pro-inflammatory cytokines: The link between obesity and osteoarthritis. Cytokine Growth Factor Rev. 2018;: pubmed publisher
    ..TNF-α, IL-6 and IL-1 are the factors released by fat to negatively regulate cartilage directly...
  22. Griffiths K, Aggarwal B, Singh R, Buttar H, Wilson D, de Meester F. Food Antioxidants and Their Anti-Inflammatory Properties: A Potential Role in Cardiovascular Diseases and Cancer Prevention. Diseases. 2016;4: pubmed publisher
    ..reduction in oxidative stress in the intervention group (Mediterranean diet + Virgin Olive Oil) compared to the low-fat diet group...
  23. Markova M, Pivovarova O, Hornemann S, Sucher S, Frahnow T, Wegner K, et al. Isocaloric Diets High in Animal or Plant Protein Reduce Liver Fat and Inflammation in Individuals With Type 2 Diabetes. Gastroenterology. 2017;152:571-585.e8 pubmed publisher
    ..High-protein diets, rich in methionine and branched chain amino acids (BCAAs), apparently reduce liver fat, but can induce insulin resistance...
  24. Dong P, Pan L, Zhang X, Zhang W, Wang X, Jiang M, et al. Hawthorn (Crataegus pinnatifida Bunge) leave flavonoids attenuate atherosclerosis development in apoE knock-out mice. J Ethnopharmacol. 2017;198:479-488 pubmed publisher
    ..High-fat diet (HFD) mixed with HLF at concentrations of 5mg/kg and 20mg/kg were administered to apolipoprotein E (apoE) ..
  25. Yorsin S, Kanokwiroon K, Radenahmad N, Jansakul C. Effects of Kaempferia parviflora rhizomes dichloromethane extract on vascular functions in middle-aged male rat. J Ethnopharmacol. 2014;156:162-74 pubmed publisher
    ..In addition, the body weight, serum glucose and triglycerides levels, visceral and subcutaneous fat, as well as liver lipid accumulation were all significantly decreased in the KPD treated rats compared to those of ..
  26. Rudyk O, Eaton P. Examining a role for PKG I? oxidation in the pathogenesis of cardiovascular dysfunction during diet-induced obesity. Free Radic Biol Med. 2017;110:390-398 pubmed publisher
    ..WT or KI mice were then subjected to a diet-induced obesity protocol by feeding them with a high fat Western-type diet (RM 60% AFE) for 27 weeks, which increased body mass, adiposity, plasma leptin, resistin and ..
  27. Kandel Kfir M, Almog T, Shaish A, Shlomai G, Anafi L, Avivi C, et al. Interleukin-1α deficiency attenuates endoplasmic reticulum stress-induced liver damage and CHOP expression in mice. J Hepatol. 2015;63:926-33 pubmed publisher
    ER stress promotes liver fat accumulation and induction of inflammatory cytokines, which contribute to the development of steatohepatitis. Unresolved ER stress upregulates the pro-apoptotic CHOP...
  28. Vallandro J, da Silveira Klein Campos L, Neumann L, de Mello E. Adductor muscle thickness of the thumb: A new and reliable parameter for nutritional assessment of pediatric inpatients. Clin Nutr. 2018;: pubmed publisher
    ..2 ± 1.4 years. Low APMT was significantly associated with underweight, short stature, low body fat percentage, and poor muscle reserve (p < 0.001)...
  29. Chiang J, Kaysen G, Schafer A, Delgado C, Johansen K. Fibroblast Growth Factor 23 is Associated With Adiposity in Patients Receiving Hemodialysis: Possible Cross Talk Between Bone and Adipose Tissue. J Ren Nutr. 2018;28:278-282 pubmed publisher
    ..Outcome measures of adiposity included body mass index, waist circumference, and body fat measured by bioelectrical impedance spectroscopy. Mean age was 56 ± 14 years, 39...
  30. Charoenphandhu N, Suntornsaratoon P, Sa Nguanmoo P, Tanajak P, Teerapornpuntakit J, Aeimlapa R, et al. Dipeptidyl Peptidase-4 Inhibitor, Vildagliptin, Improves Trabecular Bone Mineral Density and Microstructure in Obese, Insulin-Resistant, Pre-diabetic Rats. Can J Diabetes. 2018;42:545-552 pubmed publisher
    ..aimed to investigate the effects of vildagliptin, an inhibitor of dipeptidyl peptidase-4, on bone of rats with high-fat-diet-induced prediabetes...
  31. Lee E, Shin H, Seo J, Nam Y, Lee B, Seo D. Effects of raw potato starch on body weight with controlled glucose delivery. Food Chem. 2018;256:367-372 pubmed publisher
    ..Interestingly, a potato starch-based diet caused significantly (P?<?0.05) lower weight gain and fat accumulation compared to diets based on other starches, through increased insulin sensitivity...
  32. Foldyna B, Troschel F, Addison D, Fintelmann F, Elmariah S, Furman D, et al. Computed tomography-based fat and muscle characteristics are associated with mortality after transcatheter aortic valve replacement. J Cardiovasc Comput Tomogr. 2018;12:223-228 pubmed publisher
    Computed tomography (CT)-based fat and muscle measures are associated with outcome in large populations. We tested if muscle and fat characteristics are associated with long-term outcomes after TAVR...
  33. Vaurs C, Diméglio C, Charras L, Anduze Y, Chalret Du Rieu M, Ritz P. Determinants of changes in muscle mass after bariatric surgery. Diabetes Metab. 2015;41:416-21 pubmed publisher
    ..There is an expectation of a limited loss of lean body mass (LBM), and a significant loss of fat mass (FM) as well as muscle mass (MM), which could lead to functional loss and metabolic impairment...
  34. Schieda N, Lim R, McInnes M, Thomassin I, Renard Penna R, Tavolaro S, et al. Characterization of small (<4cm) solid renal masses by computed tomography and magnetic resonance imaging: Current evidence and further development. Diagn Interv Imaging. 2018;99:443-455 pubmed publisher
    ..b>Fat-poor angiomyolipoma show homogeneously increased unenhanced attenuation, homogeneously low signal on T2-weighted ..
  35. Zhang Z, Xu W, Tang R, Li L, Refaey M, Li D. Thermally processed diet greatly affects profiles of amino acids rather than fatty acids in the muscle of carnivorous Silurus meridionalis. Food Chem. 2018;256:244-251 pubmed publisher
    ..5% and 10.7% of lysine in E1 and E2, respectively. Conversely, it increased 45.4% and 83.4% of dispensable fatty acid proline. These results suggest TD could affect the nutritional quality of protein rather than fat in farmed fish.
  36. Sundararajan L, Norris M, Lundquist E. SDN-1/Syndecan Acts in Parallel to the Transmembrane Molecule MIG-13 to Promote Anterior Neuroblast Migration. G3 (Bethesda). 2015;5:1567-74 pubmed publisher
    ..Initial QR and QL migration is controlled by the transmembrane receptors UNC-40/DCC, PTP-3/LAR, and the Fat-like cadherin CDH-4...
  37. Buscato M, Hara L, Bonomi É, Calligaris G, Cardoso L, Grimaldi R, et al. Delaying fat bloom formation in dark chocolate by adding sorbitan monostearate or cocoa butter stearin. Food Chem. 2018;256:390-396 pubmed publisher
    ..butter stearin (CBSt) or sorbitan monostearate (SMS) and compared to a standard formulation in order to investigate fat bloom formation over time...
  38. Bround M, Wambolt R, Cen H, Asghari P, Albu R, Han J, et al. Cardiac Ryanodine Receptor (Ryr2)-mediated Calcium Signals Specifically Promote Glucose Oxidation via Pyruvate Dehydrogenase. J Biol Chem. 2016;291:23490-23505 pubmed
    ..context of well preserved contractile function in perfused hearts, we observed decreased glucose oxidation, but not fat oxidation, with increased glycolysis...
  39. Zeng Z, Yang H, Wang Y, Ren J, Dai Y, Dai C. Omega-3 Polyunsaturated Fatty Acids Attenuate Fibroblast Activation and Kidney Fibrosis Involving MTORC2 Signaling Suppression. Sci Rep. 2017;7:46146 pubmed publisher
    ..A Caenorhabditis elegans fat-1 transgenic mouse model in which n-3 PUFAs are endogenously produced from n-6 PUFAs owing to the expression of n-3 ..
  40. Polus A, Bociaga Jasik M, Czech U, Goralska J, Cialowicz U, Chojnacka M, et al. The human immunodeficiency virus (HIV1) protease inhibitor sanquinavir activates autophagy and removes lipids deposited in lipid droplets. J Physiol Pharmacol. 2017;68:283-293 pubmed
    ..therapy may also be associated with lipodystrophy characterized as peripheral lipoatrophy with central fat accumulation...
  41. Bouabout G, Ayme Dietrich E, Jacob H, Champy M, Birling M, Pavlovic G, et al. Nox4 genetic inhibition in experimental hypertension and metabolic syndrome. Arch Cardiovasc Dis. 2018;111:41-52 pubmed publisher
    ..enzyme could improve blood pressure and metabolic parameters in mice receiving either angiotensin II or a high-fat diet...
  42. Zhang F, Wang J, Thakur K, Hu F, Zhang J, Jiang X, et al. Isolation functional characterization of allatotropin receptor from the cotton bollworm, Helicoverpa armigera. Peptides. 2017;: pubmed publisher
    ..Helar-ATR mRNA in larvae showed the highest level in the brain, followed by the thorax ganglion, abdomen ganglion, fat body and midgut...
  43. Toffano R, Hillesheim E, Mathias M, Coelho Landell C, Salomão R, Almada M, et al. Validation of the Brazilian Healthy Eating Index-Revised Using Biomarkers in Children and Adolescents. Nutrients. 2018;10: pubmed publisher
    ..with intakes of omega-6, omega-3, fiber and vitamin C, and inversely associated with energy and saturated fat intakes of individuals. Plasma ?-carotene and riboflavin biomarkers were positively associated with total BHEI-R...
  44. Jaikumkao K, Pongchaidecha A, Chueakula N, Thongnak L, Wanchai K, Chatsudthipong V, et al. Renal outcomes with sodium glucose cotransporter 2 (SGLT2) inhibitor, dapagliflozin, in obese insulin-resistant model. Biochim Biophys Acta Mol Basis Dis. 2018;1864:2021-2033 pubmed publisher
    ..glucose cotransporter 2 (SGLT2) inhibitor, on renal and renal organic anion transporter 3 (Oat3) functions in high-fat diet fed rats, a model of obese insulin-resistance...
  45. Šedová L, Tóthová V, Olišarová V, Adámkova V, Bártlová S, Dolák F, et al. Evaluation of selected indicators of overweight and obesity of Roma minority in the region of South Bohemia. Neuro Endocrinol Lett. 2015;36 Suppl 2:35-42 pubmed
    ..and obesity: body height and weight, waistline measurement, waist/height index, waist/hips index, BMI, total fat and blood pressure...
  46. Bernsmeier C, Dill M, Provenzano A, Makowska Z, Krol I, Muscogiuri G, et al. Hepatic Notch1 deletion predisposes to diabetes and steatosis via glucose-6-phosphatase and perilipin-5 upregulation. Lab Invest. 2016;96:972-80 pubmed publisher
    ..Hepatocyte-specific Notch1 KO mice were fed with a high fat diet (HFD) or a regular diet (RD)...
  47. Mi Y, Qi G, Fan R, Ji X, Liu Z, Liu X. EGCG ameliorates diet-induced metabolic syndrome associating with the circadian clock. Biochim Biophys Acta Mol Basis Dis. 2017;1863:1575-1589 pubmed publisher
    ..Our goal was to investigate the regulating effect of EGCG treatment on metabolic misalignment triggered by a high-fat and high-fructose diet (HFFD) associating with the circadian clock...
  48. Buccarello L, Grignaschi G, Di Giancamillo A, Domeneghini C, Melcangi R, Borsello T. Neuroprotective effects of low fat-protein diet in the P301L mouse model of tauopathy. Neuroscience. 2017;354:208-220 pubmed publisher
    ..We investigated whether a low fat-protein diet (LFPD) may improve lifespan, cognitive and locomotor activity in P301L-tg mouse model of tauopathy...
  49. Soady K, Tornillo G, Kendrick H, Meniel V, Olijnyk Dallis D, Morris J, et al. The receptor protein tyrosine phosphatase PTPRB negatively regulates FGF2-dependent branching morphogenesis. Development. 2017;144:3777-3788 pubmed publisher
    ..i>In vivo shRNA knockdown of Ptprb in the cleared mammary fat pad transplant assay resulted in smaller epithelial outgrowths with an increased branching density and also ..
  50. Hsieh C, Peng S, Chou M. Obesity enhances carcinogen 7, 12-Dimethylbenz [a] anthracene -induced tumorigenesis in vitro and in vivo. Food Chem Toxicol. 2017;110:156-164 pubmed publisher
    ..C57BL/6J female mice were fed a low fat (LF), or high fat (HF) diet, and DMBA was administered by oral gavage (LF plus DMBA [LFD] and HF plus DMBA [HFD])...
  51. Wu H, Liu Q, Kalavagunta P, Huang Q, Lv W, An X, et al. Normal diet Vs High fat diet - A comparative study: Behavioral and neuroimmunological changes in adolescent male mice. Metab Brain Dis. 2018;33:177-190 pubmed publisher
    Recent evidence has established that consumption of High-fat diet (HFD)-induced obesity is associated with deficits in hippocampus-dependent memory/learning and mood states...
  52. Setchell K, Heubi J, Shah S, Lavine J, Suskind D, Al Edreesi M, et al. Genetic defects in bile acid conjugation cause fat-soluble vitamin deficiency. Gastroenterology. 2013;144:945-955.e6; quiz e14-5 pubmed publisher
    ..molecular, and morphologic features of a genetic defect in bile acid conjugation in 10 pediatric patients with fat-soluble vitamin deficiency, some with growth failure or transient neonatal cholestatic hepatitis...
  53. Shah R, Allison M, Lima J, Bluemke D, Abbasi S, Ouyang P, et al. Liver fat, statin use, and incident diabetes: The Multi-Ethnic Study of Atherosclerosis. Atherosclerosis. 2015;242:211-7 pubmed publisher
    ..216 T2D cases were diagnosed at median 9.1 years follow-up. High liver fat and statin therapy were associated with diabetes (HR 2.06 [95%CI 1.52-2.79, P < 0.0001] and 2.01 [95%CI 1.46-2...
  54. Rostoker R, Ben Shmuel S, Rashed R, Shen Orr Z, LeRoith D. CD24 cell surface expression in Mvt1 mammary cancer cells serves as a biomarker for sensitivity to anti-IGF1R therapy. Breast Cancer Res. 2016;18:51 pubmed publisher
    ..The tumorigenic capacity of each was determined following orthotopic inoculation into the mammary fat pad of female mice...
  55. Lin Y, Chen Y, Zhu N, Zhao S, Fan J, Liu E. Hydrogen sulfide inhibits development of atherosclerosis through up-regulating protein S-nitrosylation. Biomed Pharmacother. 2016;83:466-476 pubmed publisher
    ..Atherosclerosis was induced by Western diet (21% fat and 0...
  56. Chorner Z, Barbeau P, Castellani L, Wright D, Chabowski A, Holloway G. Dietary α-linolenic acid supplementation alters skeletal muscle plasma membrane lipid composition, sarcolemmal FAT/CD36 abundance, and palmitate transport rates. Am J Physiol Regul Integr Comp Physiol. 2016;311:R1234-R1242 pubmed publisher
    ..coincided with increased sarcolemmal palmitate transport rates (+20%), plasma membrane fatty acid translocase (FAT/CD36; +20%) abundance, skeletal muscle triacylglycerol content (approximately twofold), and rates of whole body fat ..
  57. Suzuki T, Gao J, Ishigaki Y, Kondo K, Sawada S, Izumi T, et al. ER Stress Protein CHOP Mediates Insulin Resistance by Modulating Adipose Tissue Macrophage Polarity. Cell Rep. 2017;18:2045-2057 pubmed publisher
    ..A high-fat diet (HFD) enhances ER stress with CHOP upregulation in adipocytes...
  58. Gibbs J, Giangregorio L, Wong A, Josse R, Cheung A. Appendicular and whole body lean mass outcomes are associated with finite element analysis-derived bone strength at the distal radius and tibia in adults aged 40years and older. Bone. 2017;103:47-54 pubmed publisher
    ..this cross-sectional study was to determine how appendicular lean mass index (ALMI), and whole body lean (LMI) and fat mass indices (FMI) associate with estimated bone strength outcomes at the distal radius and tibia in adults aged 40 ..
  59. Li J, He W, Liao B, Yang J. FFA-ROS-P53-mediated mitochondrial apoptosis contributes to reduction of osteoblastogenesis and bone mass in type 2 diabetes mellitus. Sci Rep. 2015;5:12724 pubmed publisher
    ..db/db and high fat (HF)-fed mice were treated by Etomoxir, an inhibitor of CPT1, MitoQ, and PFT-α, an inhibitor of P53...
  60. Toral P, Bernard L, Belenguer A, Rouel J, Hervás G, Chilliard Y, et al. Comparison of ruminal lipid metabolism in dairy cows and goats fed diets supplemented with starch, plant oil, or fish oil. J Dairy Sci. 2016;99:301-16 pubmed publisher
    Direct comparison of cow and goat performance and milk fatty acid responses to diets known to induce milk fat depression (MFD) in the bovine reveals relevant species-by-diet interactions in ruminal lipid metabolism...
  61. da Silva G, Ferreira de Jesus E, Takiya C, Del Valle T, da Silva T, Vendramini T, et al. Short communication: Partial replacement of ground corn with algae meal in a dairy cow diet: Milk yield and composition, nutrient digestibility, and metabolic profile. J Dairy Sci. 2016;99:8880-8884 pubmed publisher
    ..Cows showed similar milk yield and composition. The 3.5% fat-corrected milk production was 30.2±1.34kg/d for CON and 31.1±1.42kg/d for ALG...
  62. Dumas L, Briand F, Clerc R, Brousseau E, Montemagno C, Ahmadi M, et al. Evaluation of Antiatherogenic Properties of Ezetimibe Using 3H-Labeled Low-Density-Lipoprotein Cholesterol and 99mTc-cAbVCAM1-5 SPECT in ApoE-/- Mice Fed the Paigen Diet. J Nucl Med. 2017;58:1088-1093 pubmed publisher
    ..25% cholesterol, 0.5% cholic acid, and 15% fat) without or with ezetimibe (7 mg/kg/d) for 6 wk...
  63. Naseri N, Ajorlou E, Asghari F, Pilehvar Soltanahmadi Y. An update on nanoparticle-based contrast agents in medical imaging. Artif Cells Nanomed Biotechnol. 2017;:1-11 pubmed publisher
    ..as short blood half life, nonspecific biodistribution, fast clearance, slight renal toxicity and poor contrast in fat patients...
  64. Wroblewska B, Juskiewicz J, Kroplewski B, Jurgoński A, Wasilewska E, Złotkowska D, et al. The effects of whey and soy proteins on growth performance, gastrointestinal digestion, and selected physiological responses in rats. Food Funct. 2018;9:1500-1509 pubmed publisher
    ..Rats from the S group had the lowest values of body weight, fat, and lean mass gain...
  65. Girma T, Mossie A, Getu Y. Association between body composition and khat chewing in Ethiopian adults. BMC Res Notes. 2015;8:680 pubmed publisher
    ..Sociodemographic and lifestyle data were collected using structured questionnaires. Fat mass (FM, kg) and fat-free mass (FFM, kg) were estimated from whole-body bio impedance...
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    ..Other secondary pharmacological actions of DPP-4 inhibitors include mobilisation and burning of fat during meals, decrease in fat extraction from the gut, reduction of fasting lipolysis and liver fat and increase in ..
  67. Pandolfi J, Ferraro A, Sananez I, Gancedo M, Baz P, Billordo L, et al. ATP-Induced Inflammation Drives Tissue-Resident Th17 Cells in Metabolically Unhealthy Obesity. J Immunol. 2016;196:3287-96 pubmed publisher
    ..For this reason, it is critically important to determine how hypertrophic fat tissue alters T cell balance to drive inflammation...
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    ..Hyperinsulinemic-euglycemic clamps and abdominal fat distribution were performed at baseline and day 28 of overfeeding and skeletal muscle biopsies taken at baseline, ..
  69. Hammad S, Jones P. Dietary Fatty Acid Composition Modulates Obesity and Interacts with Obesity-Related Genes. Lipids. 2017;52:803-822 pubmed publisher
    ..The scientific evidence has associated obesity risk with many independent factors including the quality of dietary fat and genetics. Dietary fat exists as the main focus of dietary guidelines targeting obesity reduction...
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    ..300 mg/kg/day levels could reduce the development of overweight and insulin resistance in C57 BL/6J mice fed a high-fat diet in 12 weeks...
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    ..ESF impaired hepatic function and caused fat accumulation in the liver after oral administration (1.25 and 2.5 g/kg for 14 days in rats)...
  72. Grzelak Błaszczyk K, Milala J, Kosmala M, Kołodziejczyk K, Sójka M, Czarnecki A, et al. Onion quercetin monoglycosides alter microbial activity and increase antioxidant capacity. J Nutr Biochem. 2018;56:81-88 pubmed publisher
    ..processes in the digestive tract, the biochemical parameters and antioxidant capacity of blood in rats fed high-fat diets with quercetin (Q) and quercetin with quercetin monoglycosides (Q+MQ) preparations obtained from onion waste ..
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    ..embolism, sepsis, myocardial infarction) and also of procedure-specific problems (cement-related cardiac events, fat embolism) and local complications (neurovascular injuries)...
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    ..The level of total PEs tended to decrease in the livers of rats on high fat diets compared with controls...
  75. Santschi D, Lacroix R, Durocher J, Duplessis M, Moore R, Lefebvre D. Prevalence of elevated milk ?-hydroxybutyrate concentrations in Holstein cows measured by Fourier-transform infrared analysis in Dairy Herd Improvement milk samples and association with milk yield and components. J Dairy Sci. 2016;99:9263-9270 pubmed publisher
    ..milk yield, protein concentration and yield, and lower Transition Cow Index than negative cows, but also higher fat concentration and yield, as well as higher somatic cell count than negative cows...
  76. Woller A, Duez H, Staels B, Lefranc M. A Mathematical Model of the Liver Circadian Clock Linking Feeding and Fasting Cycles to Clock Function. Cell Rep. 2016;17:1087-1097 pubmed publisher
    ..patterns of AMPK activation was simulated numerically, mimicking the effects of a normal diet, fasting, and a high-fat diet...
  77. Ma H, Sales V, Wolf A, Subramanian S, Matthews T, Chen M, et al. Attenuated Effects of Bile Acids on Glucose Metabolism and Insulin Sensitivity in a Male Mouse Model of Prenatal Undernutrition. Endocrinology. 2017;158:2441-2452 pubmed publisher
    ..5 to 18.5. Offspring of both undernourished (UN) and control (C) dams given unrestricted diets were weaned to high-fat diets with or without supplementation with 0...
  78. Wei W, Sun W, Han H, Chu W, Zhang L, Chen J. miR-130a regulates differential lipid accumulation between intramuscular and subcutaneous adipose tissues of pigs via suppressing PPARG expression. Gene. 2017;636:23-29 pubmed publisher
    ..the molecular mechanism underlying differential lipid deposition between intramuscular (IM) and subcutaneous (SC) fat tissues of pigs, peroxisome proliferator-activated receptor gamma (PPARG) expression levels were compared in these ..
  79. Kamitakahara A, Bouyer K, Wang C, Simerly R. A critical period for the trophic actions of leptin on AgRP neurons in the arcuate nucleus of the hypothalamus. J Comp Neurol. 2018;526:133-145 pubmed publisher
    In the developing hypothalamus, the fat-derived hormone leptin stimulates the growth of axons from the arcuate nucleus of the hypothalamus (ARH) to other regions that control energy balance...
  80. Iwasa T, Matsuzaki T, Yiliyasi M, Yano K, Irahara M. The effects of chronic testosterone administration on body weight, food intake, and fat weight were age-dependent. Steroids. 2017;127:18-23 pubmed publisher
    ..showed that chronic testosterone administration increased body weight (BW) and food intake (FI), but did not alter fat weight, in young female rats...
  81. Loiselle D, Barclay C. The Ineluctable Constraints of Thermodynamics in the Aetiology of Obesity. Clin Exp Pharmacol Physiol. 2017;: pubmed publisher
    ..Quantification of the energy expended, in the form of fat metabolised, during selected endurance events, reveals the inherent limitation of over-reliance on exercise as a ..
  82. Bang H, Seo D, Chung Y, Kim D, Lee S, Lee S, et al. Ursolic acid supplementation decreases markers of skeletal muscle damage during resistance training in resistance-trained men: a pilot study. Korean J Physiol Pharmacol. 2017;21:651-656 pubmed publisher
    ..and markers of skeletal muscle damage, whereas RT+UA group showed slightly decreased body weight and body fat percentage and slightly increased lean body mass, but without statistical significance...
  83. Rolls B, Bell E. Dietary approaches to the treatment of obesity. Med Clin North Am. 2000;84:401-18, vi pubmed
    ..Reducing the fat content of the diet and increasing physical activity without restricting energy intake are relatively inefficient ..
  84. Smith B, Volaufova J, West D. Increased flavor preference and lick activity for sucrose and corn oil in SWR/J vs. AKR/J mice. Am J Physiol Regul Integr Comp Physiol. 2001;281:R596-606 pubmed
    ..vehicle; ascending concentrations), the effects of strain and chow type (12 or 26% fat) on preference thresholds for sucrose and corn oil were compared in AKR/J and SWR/J mice...
  85. Kim D, Cho J, Lee I, Jin Y, Kang H. Exercise Attenuates High-Fat Diet-induced Disease Progression in 3xTg-AD Mice. Med Sci Sports Exerc. 2017;49:676-686 pubmed publisher
    Little is known regarding the therapeutic role of exercise against the risk of a high-fat diet (HFD) for Alzheimer's disease (AD) and AD-like cognitive deficits...
  86. Kurhe Y, Mahesh R, Devadoss T. Novel 5-HT3 receptor antagonist QCM-4 attenuates depressive-like phenotype associated with obesity in high-fat-diet-fed mice. Psychopharmacology (Berl). 2017;234:1165-1179 pubmed publisher
    ..factor (BDNF), serotonin (5-HT) concentrations, hippocampal neuronal damage, and p53 protein expression in high-fat-diet (HFD)-fed mice...
  87. Lee J, Narayan V, Hong E, Whang W, Park T. Artemisia Iwayomogi Extract Attenuates High-Fat Diet-Induced Hypertriglyceridemia in Mice: Potential Involvement of the Adiponectin-AMPK Pathway and Very Low Density Lipoprotein Assembly in the Liver. Int J Mol Sci. 2017;18: pubmed publisher
    ..the protective effect of Artemisia iwayomogi extract (AI) against hypertriglyceridemia induced by a high-fat diet (HFD) in mice and to uncover the underlying molecular mechanisms. C57BL/6N mice were fed chow, HFD, HFD + 0...
  88. Beretta E, Franzini A, Cordella R, Nazzi V, Valentini L, Franzini A. Surgical "Fat Patch" Improves Secondary Intracranial Hypotension Orthostatic Headache Associated with Lumbosacral Dural Ectasia. World Neurosurg. 2017;107:1053.e7-1053.e10 pubmed publisher
    ..Altered compliance of the dural spinal sac was suspected. Therefore thecal sac remodeling by placing autologous fat at the level of the dural ectasia was performed, improving the symptoms for 2 years...
  89. Jolly Y, Iqbal S, Rahman M, Kabir J, Akter S, Ahmad I. Energy dispersive X-ray fluorescence detection of heavy metals in Bangladesh cows' milk. Heliyon. 2017;3:e00403 pubmed publisher
    ..The main compositions of cow's milk are protein, fat, carbohydrates, vitamins and minerals which are well defined...
  90. Majumder S, Philip N, Takahashi N, Levy M, Singh V, Chari S. Fatty Pancreas: Should We Be Concerned?. Pancreas. 2017;46:1251-1258 pubmed publisher
    The metabolic consequences of visceral fat deposition are well known, and the presence of intrapancreatic fat (IPF) has been recognized for decades...
  91. Lin T, Peng C, Hung S, Tarng D. Body composition is associated with clinical outcomes in patients with non-dialysis-dependent chronic kidney disease. Kidney Int. 2018;93:733-740 pubmed publisher
    ..However, it is unclear whether increased muscle mass or body fat confers the survival advantage...
  92. Khabaz M, Abdelrahman A, Butt N, Damnhory L, Elshal M, Aldahlawi A, et al. Immunohistochemical staining of leptin is associated with grade, stage, lymph node involvement, recurrence, and hormone receptor phenotypes in breast cancer. BMC Womens Health. 2017;17:105 pubmed publisher
    ..Circulating leptin increases in parallel with the increase of body weight and fat reservoir. This research investigated the link between leptin phenotype and the clinicopathological factors in BC...