FasL

Summary

Gene Symbol: FasL
Description: Fas ligand
Alias: ALPS1B, APT1LG1, APTL, CD178, CD95-L, CD95L, FASL, TNFSF6, TNLG1A, tumor necrosis factor ligand superfamily member 6, CD95 ligand, Fas ligand (TNF superfamily, member 6), apoptosis (APO-1) antigen ligand 1, apoptosis antigen ligand, fas antigen ligand, mutant tumor necrosis factor family member 6, tumor necrosis factor ligand 1A
Species: human
Products:     FasL

Top Publications

  1. Stuck B, Pani M, Besrour F, Segni M, Krause M, Usadel K, et al. Fas ligand gene polymorphisms are not associated with Hashimoto's thyroiditis and Graves' disease. Hum Immunol. 2003;64:285-9 pubmed
    ..Whereas in Hashimoto's thyroiditis FasL expression causes thyrocytes to undergo apoptosis, additional anti-apoptotic molecules appear to protect these ..
  2. Yang M, Sun T, Wang L, Yu D, Zhang X, Miao X, et al. Functional variants in cell death pathway genes and risk of pancreatic cancer. Clin Cancer Res. 2008;14:3230-6 pubmed publisher
    Fas-Fas ligand (FasL)-mediated death pathway is important in the life and death of immune cells and, therefore, influences immune surveillance of carcinogenesis...
  3. Park J, Lee W, Jung D, Choi J, Park T, Lee E, et al. Polymorphisms in the FAS and FASL genes and survival of early stage non-small cell lung cancer. Clin Cancer Res. 2009;15:1794-800 pubmed publisher
    This study was conducted to investigate the impact of functional polymorphisms in the FAS and FASL genes on the survival of early stage non-small cell lung cancer (NSCLC) patients...
  4. Ivansson E, Gustavsson I, Magnusson J, Steiner L, Magnusson P, Erlich H, et al. Variants of chemokine receptor 2 and interleukin 4 receptor, but not interleukin 10 or Fas ligand, increase risk of cervical cancer. Int J Cancer. 2007;121:2451-7 pubmed
    ..V64I; Interleukin 4 receptor alpha (IL-4R) I75V, S503P and Q576R; Interleukin 10 (IL-10) -592; and Fas ligand (FasL) -844...
  5. Zhang B, Sun T, Xue L, Han X, Zhang B, Lu N, et al. Functional polymorphisms in FAS and FASL contribute to increased apoptosis of tumor infiltration lymphocytes and risk of breast cancer. Carcinogenesis. 2007;28:1067-73 pubmed
    The FAS-FASL system plays crucial role in counterattack of cancer cell against immune system...
  6. Randhawa S, Chahine B, Lowery Nordberg M, Cotelingam J, Casillas A. Underexpression and overexpression of Fas and Fas ligand: a double-edged sword. Ann Allergy Asthma Immunol. 2010;104:286-92 pubmed publisher
    ..syndrome (ALPS) and Stevens-Johnson syndrome (SJS) with respect to the defects in Fas- and Fas ligand (FasL)-mediated apoptosis...
  7. Kim H, Jin X, Kim H, Lee I, Park K, Park M, et al. Fas and FasL polymorphisms are not associated with acute myeloid leukemia risk in Koreans. DNA Cell Biol. 2010;29:619-24 pubmed publisher
    Fas and Fas ligand (FasL) polymorphisms in the promoter regions influence transcriptional activities. The interaction of these two genes plays a crucial role in apoptotic cell death regulation...
  8. Yang S, Miao X, Zhang X, Sun T, Qu S, Xiong P, et al. [Genetic polymorphisms of apoptosis-associated genes FAS and FASL and risk of colorectal cancer]. Zhonghua Yi Xue Za Zhi. 2005;85:2132-5 pubmed
    The FAS and FASL system plays a key role in regulating apoptotic cell death and corruption of this signaling pathway has been shown to participate in tumorigenesis...
  9. Kupcinskas J, Wex T, Bornschein J, Selgrad M, Leja M, Juozaityte E, et al. Lack of association between gene polymorphisms of Angiotensin converting enzyme, Nod-like receptor 1, Toll-like receptor 4, FAS/FASL and the presence of Helicobacter pylori-induced premalignant gastric lesions and gastric cancer in Caucasians. BMC Med Genet. 2011;12:112 pubmed publisher
    ..genes encoding Angiotensin converting enzyme (ACE), Nod-like receptor 1 (NOD1), Toll-like receptor 4 (TLR4) and FAS/FASL. Gene polymorphisms were analyzed in 574 subjects (GC: n = 114; HRAG: n = 222, controls: n = 238) of Caucasian ..

More Information

Publications63

  1. Elhalel M, Huang J, Schmidt W, Rachmilewitz J, Tykocinski M. CTLA-4. FasL induces alloantigen-specific hyporesponsiveness. J Immunol. 2003;170:5842-50 pubmed
    ..Fas ligand (FasL), that has the inherent capacities to tether the T cell inhibitor FasL (CD95 ligand) to the surfaces of B7 (CD80 and CD86)-positive APC (via CTLA-4:B7 interaction), and in so doing, to ..
  2. Li Y, Hao Y, Kang S, Zhou R, Wang N, Qi B. Genetic polymorphisms in the Fas and FasL genes are associated with epithelial ovarian cancer risk and clinical outcomes. Gynecol Oncol. 2013;128:584-9 pubmed publisher
    In this study, we evaluated whether functional polymorphisms within the Fas and FasL genes were associated with the risk of developing epithelial ovarian cancer (EOC) and survival of patients with EOC...
  3. Micheau O, Tschopp J. Induction of TNF receptor I-mediated apoptosis via two sequential signaling complexes. Cell. 2003;114:181-90 pubmed
    ..Thus, TNFR1-mediated-signal transduction includes a checkpoint, resulting in cell death (via complex II) in instances where the initial signal (via complex I, NF-kappa B) fails to be activated. ..
  4. Zhou R, Wang N, Chen Z, Duan Y, Sun D, Li Y. Polymorphisms in promoter region of FAS and FASL gene and risk of cardia gastric adenocarcinoma. J Gastroenterol Hepatol. 2010;25:555-61 pubmed publisher
    The FAS and FASL system play an important role in regulating apoptotic cell death...
  5. Singhal S, Chakravarty A, Das B, Kar P. Tumour necrosis factor-alpha and soluble Fas ligand as biomarkers in non-acetaminophen-induced acute liver failure. Biomarkers. 2009;14:347-53 pubmed publisher
    ..The high levels of sFasL and TNF-alpha are associated with ALF. Following the trend of these cytokines can be useful in predicting death and timely referral to a transplant centre. ..
  6. Vasilescu A, Heath S, Diop G, Do H, Hirtzig T, Hendel H, et al. Genomic analysis of Fas and FasL genes and absence of correlation with disease progression in AIDS. Immunogenetics. 2004;56:56-60 pubmed
    ..acquired immunodeficiency syndrome (AIDS), we have performed an extensive genetic analysis of Fas and Fas ligand ( FasL) genes...
  7. Liu Y, Wen Q, Yin Y, Lu X, Pu S, Tian H, et al. FASLG polymorphism is associated with cancer risk. Eur J Cancer. 2009;45:2574-8 pubmed publisher
    ..However, more comprehensive understanding of the association would certainly have an immense prospect in the promising field of individualised preventive care. ..
  8. Zhang Z, Qiu L, Wang M, Tong N, Li J, Zhang Z. The FAS ligand promoter polymorphism, rs763110 (-844C>T), contributes to cancer susceptibility: evidence from 19 case-control studies. Eur J Hum Genet. 2009;17:1294-303 pubmed publisher
    The potentially functional polymorphism, rs763110 (-844C>T), in the promoter region of the FAS ligand (FASL) gene, has been implicated in cancer risk, but individually published studies show inconclusive results...
  9. Barnhart B, Legembre P, Pietras E, Bubici C, Franzoso G, Peter M. CD95 ligand induces motility and invasiveness of apoptosis-resistant tumor cells. EMBO J. 2004;23:3175-85 pubmed
    ..Despite its apoptotic potential, most human tumors are refractory to the cytotoxic effects of CD95 ligand. We now show that CD95 stimulation of multiple apoptosis-resistant tumor cells by CD95 ligand induces increased ..
  10. Zhang W, Li C, Wang J, He C. Functional polymorphisms in FAS/FASL system contribute to the risk of occurrence but not progression of gastric cardiac adenocarcinoma. Hepatogastroenterology. 2012;59:141-6 pubmed publisher
    Loss of FAS and gain of aberrant FASL expression are common features of malignant transformation...
  11. Ter Minassian M, Zhai R, Asomaning K, Su L, Zhou W, Liu G, et al. Apoptosis gene polymorphisms, age, smoking and the risk of non-small cell lung cancer. Carcinogenesis. 2008;29:2147-52 pubmed publisher
    ..17). No interactions were observed for FAS -1377 G>A and BAT3 Ser625Pro polymorphisms. Our findings indicate that age and smoking may modify the association of the FASLG -844 and IL1B + 3954 SNPs with the risk of NSCLC. ..
  12. Karimi M, Kapoor V, Sharma S, Das S. Genetic polymorphisms in FAS (CD95) and FAS ligand (CD178) promoters and risk of tobacco-related oral carcinoma: gene-gene interactions in high-risk Indians. Cancer Invest. 2013;31:1-6 pubmed publisher
    We assessed the association of functional single nucleotide polymorphisms (SNP) in FAS -1377, -670 and FAS ligand (FASL) -844 promoters in 139 oral cancer patients and 126 normal subjects by PCR-RFLP...
  13. Jung Y, Kim Y, Kim L, Lee S, Park B, Shin H, et al. Putative association of Fas and FasL gene polymorphisms with clinical outcomes of hepatitis B virus infection. Intervirology. 2007;50:369-76 pubmed
    Fas/FasL polymorphisms, which are related to apoptosis, might influence the clearance of hepatitis B virus (HBV) infection and the occurrence of hepatocellular carcinoma (HCC)...
  14. Minas V, Jeschke U, Kalantaridou S, Richter D, Reimer T, Mylonas I, et al. Abortion is associated with increased expression of FasL in decidual leukocytes and apoptosis of extravillous trophoblasts: a role for CRH and urocortin. Mol Hum Reprod. 2007;13:663-73 pubmed
    ..Here, we examined the hypothesis that the expression of the proapoptotic Fas/FasL system at the implantation site is impaired in abortions...
  15. Zheng H, Sun J, Wei Z, Yang X, Zhang Y, Xin Y. Expression of Fas ligand and caspase-3 contributes to formation of immune escape in gastric cancer. World J Gastroenterol. 2003;9:1415-20 pubmed
    To study the role of Fas ligand (FasL) and Caspase-3 expression in carcinogenesis and progression of gastric cancer and molecular mechanisms of relevant immune escape...
  16. Schulte M, Reiss K, Lettau M, Maretzky T, Ludwig A, Hartmann D, et al. ADAM10 regulates FasL cell surface expression and modulates FasL-induced cytotoxicity and activation-induced cell death. Cell Death Differ. 2007;14:1040-9 pubmed
    The apoptosis-inducing Fas ligand (FasL) is a type II transmembrane protein that is involved in the downregulation of immune reactions by activation-induced cell death (AICD) as well as in T cell-mediated cytotoxicity...
  17. Zhai R, Chen F, Liu G, Su L, Kulke M, Asomaning K, et al. Interactions among genetic variants in apoptosis pathway genes, reflux symptoms, body mass index, and smoking indicate two distinct etiologic patterns of esophageal adenocarcinoma. J Clin Oncol. 2010;28:2445-51 pubmed publisher
    ..High-order interactions among reflux, BMI, smoking, and functional polymorphisms in five apoptotic genes (FAS, FASL, IL1B, TP53BP, and BAT3) were investigated by entropy-based multifactor dimensionality reduction (MDR), ..
  18. Park S, Choi J, Kim E, Jang J, Lee W, Cha S, et al. Polymorphisms in the FAS and FASL genes and risk of lung cancer in a Korean population. Lung Cancer. 2006;54:303-8 pubmed
    The FAS and FASL system play an important role in regulating extrinsic apoptotic pathway and inappropriate regulation of this signaling pathway contributes to lung tumorigenesis...
  19. Chen J, Wang C, Ma C, Chow Y, Luo S. The -844C/T polymorphism in the Fas ligand promoter associates with Taiwanese SLE. Genes Immun. 2005;6:123-8 pubmed
    b>FasL expression is critical in T-cell activation-induced apoptosis, which is involved in lupus pathogenesis. This study identified two SNPs in the FasL promoter regions from -1145 to -45 by genomic DNA sequencing...
  20. Del Rey M, Ruiz Contreras J, Bosque A, Calleja S, Gomez Rial J, Roldan E, et al. A homozygous Fas ligand gene mutation in a patient causes a new type of autoimmune lymphoproliferative syndrome. Blood. 2006;108:1306-12 pubmed
    ..This report describes the first homozygous FASL gene mutation in a woman with clinical and immunologic features of ALPS...
  21. Lettau M, Qian J, Linkermann A, Latreille M, Larose L, Kabelitz D, et al. The adaptor protein Nck interacts with Fas ligand: Guiding the death factor to the cytotoxic immunological synapse. Proc Natl Acad Sci U S A. 2006;103:5911-6 pubmed
    The Fas ligand (FasL) is a key death factor of cytotoxic T lymphocytes and natural killer cells. It is stored intracellularly as a transmembrane protein of secretory lysosomes...
  22. Li C, Larson D, Zhang Z, Liu Z, Strom S, Gershenwald J, et al. Polymorphisms of the FAS and FAS ligand genes associated with risk of cutaneous malignant melanoma. Pharmacogenet Genomics. 2006;16:253-63 pubmed
    ..In conclusion, genetic variants in the FAS and FASLG genes may contribute to the etiology of CMM in the general population, particularly in those with a low risk of sunlight-induced CMM. ..
  23. Sun T, Miao X, Zhang X, Tan W, Xiong P, Lin D. Polymorphisms of death pathway genes FAS and FASL in esophageal squamous-cell carcinoma. J Natl Cancer Inst. 2004;96:1030-6 pubmed
    ..system is a key regulator of apoptotic cell death, and loss of FAS expression and gain of FAS ligand (FASL) expression play important roles in the development and progression of cancer...
  24. Nachbur U, Kassahn D, Yousefi S, Legler D, Brunner T. Posttranscriptional regulation of Fas (CD95) ligand killing activity by lipid rafts. Blood. 2006;107:2790-6 pubmed
    ..Here, we now provide evidence that Fas ligand is constitutively localized in lipid rafts of FasL transfectants and primary T cells...
  25. Wu S, Zhang J, Qian W, Yang Y, Liu Y, Dong Y, et al. Altered expression of survivin, Fas and FasL contributed to cervical cancer development and metastasis. Eur Rev Med Pharmacol Sci. 2012;16:2044-50 pubmed
    ..The expressions of Survivin, Fas and FasL in tissues of cervical cancer, cervical intraepithelial neoplasia (CIN), chronic cervicitis and normal cervix wer ..
  26. Wang L, Ting S, Chen C, Tsai C, Lung O, Liu T, et al. Polymorphisms in the apoptosis-associated genes FAS and FASL and risk of oral cancer and malignant potential of oral premalignant lesions in a Taiwanese population. J Oral Pathol Med. 2010;39:155-61 pubmed publisher
    Our aim was to measure the relationship of FAS (-1377G>A and -670A>G), FASL (-844C>T) gene variants and risk of oral cancer...
  27. Zhu J, Qin C, Wang M, Yan F, Ju X, Meng X, et al. Functional polymorphisms in cell death pathway genes and risk of renal cell carcinoma. Mol Carcinog. 2010;49:810-7 pubmed publisher
    The FAS/FAS ligand (FASL) system plays a key role in regulating apoptotic cell death, and corruption of this signaling pathway has been shown to participate in tumorigenesis...
  28. Tong N, Zhang L, Sheng X, Wang M, Zhang Z, Fang Y, et al. Functional polymorphisms in FAS, FASL and CASP8 genes and risk of childhood acute lymphoblastic leukemia: a case-control study. Leuk Lymphoma. 2012;53:1360-6 pubmed publisher
    Genetic polymorphisms in the promoter regions of FAS, FASL and CASP8 involved in the apoptotic signaling pathway are thought to be associated with susceptibility to cancer...
  29. Legler D, Micheau O, Doucey M, Tschopp J, Bron C. Recruitment of TNF receptor 1 to lipid rafts is essential for TNFalpha-mediated NF-kappaB activation. Immunity. 2003;18:655-64 pubmed
    ..We suggest that lipid rafts are crucial for the outcome of TNFalpha-activated signaling pathways. ..
  30. Kang S, Dong S, Seo S, Kim J, Park S. FAS -1377 G/A polymorphism and the risk of lymph node metastasis in cervical cancer. Cancer Genet Cytogenet. 2008;180:1-5 pubmed
    Single-nucleotide polymorphisms of the FAS -1377G/A, FAS -670A/G, and FASL -844T/C genes may alter transcriptional activity of these genes...
  31. Wang W, Chen P, Wang H, Liang W, Su Y. Matrix metalloproteinase-7 increases resistance to Fas-mediated apoptosis and is a poor prognostic factor of patients with colorectal carcinoma. Carcinogenesis. 2006;27:1113-20 pubmed
    ..A critical effector of apoptosis is the Fas/Fas ligand (FasL) system that mediates the tumoricidal effects of cytotoxic T cells...
  32. Lee K, Feig C, Tchikov V, Schickel R, Hallas C, Schütze S, et al. The role of receptor internalization in CD95 signaling. EMBO J. 2006;25:1009-23 pubmed
    ..In this study, we demonstrate a general requirement of receptor internalization for CD95 ligand-mediated DISC amplification, caspase activation and apoptosis in type I cells...
  33. Zhang Z, Wang L, Sturgis E, El Naggar A, Hong W, Amos C, et al. Polymorphisms of FAS and FAS ligand genes involved in the death pathway and risk and progression of squamous cell carcinoma of the head and neck. Clin Cancer Res. 2006;12:5596-602 pubmed
    ..However, potential selection bias warrants future population-based studies to verify the findings. ..
  34. Nasi M, Pinti M, Bugarini R, Troiano L, Lugli E, Bellodi C, et al. Genetic polymorphisms of Fas (CD95) and Fas ligand (CD178) influence the rise in CD4+ T cell count after antiretroviral therapy in drug-naïve HIV-positive patients. Immunogenetics. 2005;57:628-35 pubmed
    Fas and Fas ligand (FasL) are the main genes that control cell death in the immune system. Indeed, they are crucial for the regulation of T lymphocyte homeostasis because they can influence cell proliferation...
  35. Lai H, Lin W, Lin Y, Chang C, Yu M, Chen C, et al. Genetic polymorphisms of FAS and FASL (CD95/CD95L) genes in cervical carcinogenesis: An analysis of haplotype and gene-gene interaction. Gynecol Oncol. 2005;99:113-8 pubmed
    ..The genotypes of FAS -670A/G, FAS -1377G/A, and FASL -844C/T were assessed in 143 patients with high-grade squamous intraepithelial lesions (HSIL), 175 patients with ..
  36. Kirkin V, Cahuzac N, Guardiola Serrano F, Huault S, Lückerath K, Friedmann E, et al. The Fas ligand intracellular domain is released by ADAM10 and SPPL2a cleavage in T-cells. Cell Death Differ. 2007;14:1678-87 pubmed
    Fas ligand (FasL) is a type II transmembrane protein belonging to the tumor necrosis factor family. Its binding to the cognate Fas receptor triggers the apoptosis that plays a pivotal role in the maintenance of immune system homeostasis...
  37. Sung W, Wang Y, Cheng Y, Lee M, Yeh K, Wang L, et al. A polymorphic -844T/C in FasL promoter predicts survival and relapse in non-small cell lung cancer. Clin Cancer Res. 2011;17:5991-9 pubmed publisher
    Fas ligand (FasL) -844T/C polymorphism (rs763110) has a demonstrated association with lung cancer risk. FasL -844CC with higher FasL expression has been suggested to contribute to tumor progression via immune escape...
  38. Cao Y, Miao X, Huang M, Deng L, Lin D, Zeng Y, et al. Polymorphisms of death pathway genes FAS and FASL and risk of nasopharyngeal carcinoma. Mol Carcinog. 2010;49:944-50 pubmed publisher
    ..Functional polymorphisms in the FAS (FAS -1377G/A) and FASL (FASL -844T/C) genes alter their transcriptional activity...
  39. Mahfoudh W, Bouaouina N, Gabbouj S, Chouchane L. FASL-844 T/C polymorphism: a biomarker of good prognosis of breast cancer in the Tunisian population. Hum Immunol. 2012;73:932-8 pubmed publisher
    The single nucleotide polymorphism, rs763110 (-844 T/C) of the FASL gene, is located within a putative binding motif of CAAT/enhancer-binding protein ? transcription factor...
  40. Erdogan M, Karadeniz M, Berdeli A, Tamsel S, Ertan Y, Uluer H, et al. Fas/Fas ligand gene polymorphism in patients with papillary thyroid cancer in the Turkish population. J Endocrinol Invest. 2007;30:411-6 pubmed
    Fas ligand (FasL) is an apoptotic agent and a member of tumor necrosis factor (TNF) family. FasL exists in cytotoxic T lymphocyte (CTL) and natural killer (NK) cells, and it is increased in tumor cell membrane...
  41. Zhang H, Sun X, Synnerstad I, Rosdahl I. Importance of FAS-1377, FAS-670, and FASL-844 polymorphisms in tumor onset, progression, and pigment phenotypes of Swedish patients with melanoma: a case-control analysis. Cancer J. 2007;13:233-7 pubmed
    ..The FAS gene and its natural ligand (FASL) gene initiate the death signal cascade, playing a central role in the apoptotic signaling pathway and tumor growth ..
  42. Crew K, Gammon M, Terry M, Zhang F, Agrawal M, Eng S, et al. Genetic polymorphisms in the apoptosis-associated genes FAS and FASL and breast cancer risk. Carcinogenesis. 2007;28:2548-51 pubmed
    FAS and FAS ligand (FASL) play key roles in apoptotic signaling and down-regulation of this pathway may facilitate tumorigenesis...
  43. Tsukinoki T, Sugiyama H, Sunami R, Kobayashi M, Onoda T, Maeshima Y, et al. Mesangial cell Fas ligand: upregulation in human lupus nephritis and NF-kappaB-mediated expression in cultured human mesangial cells. Clin Exp Nephrol. 2004;8:196-205 pubmed
    Fas ligand (FasL) is a well-known death factor; however, the role of FasL in the regulation of human glomerulonephritis remains unclear...
  44. Strauss L, Bergmann C, Whiteside T. Human circulating CD4+CD25highFoxp3+ regulatory T cells kill autologous CD8+ but not CD4+ responder cells by Fas-mediated apoptosis. J Immunol. 2009;182:1469-80 pubmed
    ..Treg from all subjects expressed CD95(+), but only Treg from cancer patients expressed CD95L. These Treg, when activated via TCR plus IL-2, up-regulated CD95 and CD95L expression (p < 0...
  45. Sun T, Zhou Y, Li H, Han X, Shi Y, Wang L, et al. FASL -844C polymorphism is associated with increased activation-induced T cell death and risk of cervical cancer. J Exp Med. 2005;202:967-74 pubmed
    ..Xiong, Y. Zhou, and D. Lin. 2005. J. Med. Genet. 42:479-484) that functional polymorphisms in FAS and FAS ligand (FASL) are associated with susceptibility to lung cancer and esophageal cancer; however, the mechanisms underlying this ..
  46. Li C, Wu W, Liu J, Qian L, Li A, Yang K, et al. Functional polymorphisms in the promoter regions of the FAS and FAS ligand genes and risk of bladder cancer in south China: a case-control analysis. Pharmacogenet Genomics. 2006;16:245-51 pubmed
    ..70; 95% CI 1.11-2.61) and smokers (OR=1.88; 95% CI 1.06-3.32). FAS and FASLG polymorphisms appear to jointly contribute to risk of bladder cancer in this southern Chinese population. Larger studies are needed to verify these findings. ..
  47. Razeghinejad M, Kamali Sarvestani E. Aqueous humor levels of soluble Fas and Fas-ligand in patients with primary open angle and pseudoexfoliation glaucoma. Iran J Immunol. 2007;4:215-9 pubmed
    ..The sFasL level did not show any significant difference in the three groups. A lower level of sFas may provide proper microenvironment for increased apoptosis of trabecular meshwork cells in primary open angle glaucoma. ..
  48. Gormus U, Ergen A, Yilmaz H, Dalan B, Berkman S, Isbir T. Fas-1377A/G and FasL-844 T/C gene polymorphisms and epithelial ovarian cancer. Anticancer Res. 2007;27:991-4 pubmed
    The Fas receptor is known to be widely expressed in various tissues and FasL is highly expressed on cells of the immune system and also on cells of immune-privileged areas such as the eyes and brain...
  49. Lafont E, Milhas D, Carpentier S, Garcia V, Jin Z, Umehara H, et al. Caspase-mediated inhibition of sphingomyelin synthesis is involved in FasL-triggered cell death. Cell Death Differ. 2010;17:642-54 pubmed publisher
    ..In this study, we show that in human leukemia Jurkat cells, which express mainly SMS1, Fas ligand (FasL) treatment inhibited SMS activity in a dose- and time-dependent manner before nuclear fragmentation...
  50. Cahuzac N, Baum W, Kirkin V, Conchonaud F, Wawrezinieck L, Marguet D, et al. Fas ligand is localized to membrane rafts, where it displays increased cell death-inducing activity. Blood. 2006;107:2384-91 pubmed
    Fas ligand (FasL), a member of the TNF protein family, potently induces cell death by activating its matching receptor Fas...
  51. Hsu P, Lu P, Wang E, Ger L, Lo G, Tsay F, et al. Polymorphisms of death pathway genes FAS and FASL and risk of premalignant gastric lesions. Anticancer Res. 2008;28:97-103 pubmed
    ..The aim of this study was to investigate whether functional polymorphisms of death pathway genes (FAS and FASL) are associated with the development of gastric atrophy and intestinal metaplasia...
  52. Wang M, Wu D, Tan M, Gong W, Xue H, Shen H, et al. FAS and FAS ligand polymorphisms in the promoter regions and risk of gastric cancer in Southern China. Biochem Genet. 2009;47:559-68 pubmed publisher
    ..We found that the FAS and FASL genotypes and the FAS haplotypes had no significant associations with risk of gastric cancer...
  53. Zhang X, Miao X, Sun T, Tan W, Qu S, Xiong P, et al. Functional polymorphisms in cell death pathway genes FAS and FASL contribute to risk of lung cancer. J Med Genet. 2005;42:479-84 pubmed
    The FAS and FASL system plays a key role in regulating apoptotic cell death and corruption of this signalling pathway has been shown to participate in immune escape and tumorigenesis...
  54. Wang J, Gao J, Li Y, Zhao X, Gao W, Peng L, et al. Functional polymorphisms in FAS and FASL contribute to risk of squamous cell carcinoma of the larynx and hypopharynx in a Chinese population. Gene. 2013;524:193-6 pubmed publisher
    Accumulating evidences indicate that the functional FAS-1377G>A, -670A>G and FASL-844T>C polymorphisms affect the risk of several kinds of cancers...