EAF2

Summary

Gene Symbol: EAF2
Description: ELL associated factor 2
Alias: BM040, TRAITS, U19, ELL-associated factor 2, testosterone-regulated apoptosis inducer and tumor suppressor protein
Species: human
Products:     EAF2

Top Publications

  1. Xiao W, Jiang F, Wang Z. ELL binding regulates U19/Eaf2 intracellular localization, stability, and transactivation. Prostate. 2006;66:1-12 pubmed
    U19/Eaf2, an androgen-response gene, is downregulated in advanced human prostate cancer specimens and its overexpression can markedly induce apoptosis in prostate cancer cells...
  2. Simone F, Luo R, Polak P, Kaberlein J, Thirman M. ELL-associated factor 2 (EAF2), a functional homolog of EAF1 with alternative ELL binding properties. Blood. 2003;101:2355-62 pubmed
    ..activities when fused to MLL, we isolated a second protein that interacts with ELL named EAF2 for ELL Associated Factor 2. EAF2 is highly homologous to EAF1, with 58% identity and 74% amino acid conservation...
  3. Xiao W, Zhang Q, Jiang F, Pins M, Kozlowski J, Wang Z. Suppression of prostate tumor growth by U19, a novel testosterone-regulated apoptosis inducer. Cancer Res. 2003;63:4698-704 pubmed
    ..Here, we report the identification and characterization of U19, a novel testosterone-regulated apoptosis inducer with tumor suppressive activity...
  4. Kong S, Banks C, Shilatifard A, Conaway J, Conaway R. ELL-associated factors 1 and 2 are positive regulators of RNA polymerase II elongation factor ELL. Proc Natl Acad Sci U S A. 2005;102:10094-8 pubmed
    ..In this report, we identify the ELL-associated factors (EAF)1 and EAF2 as strong positive regulators of ELL elongation activity...
  5. Dutkiewicz J, Mackiewicz B, Lemieszek M, Golec M, Milanowski J. Pantoea agglomerans: a mysterious bacterium of evil and good. Part IV. Beneficial effects. Ann Agric Environ Med. 2016;23:206-22 pubmed publisher
    Pantoea agglomerans, a gammaproteobacterium of plant origin, possesses many beneficial traits that could be used for the prevention and/or treatment of human and animal diseases, combating plant pathogens, promotion of plant growth and ..
  6. Dutkiewicz J, Zając V, Sroka J, Wasiński B, Cisak E, Sawczyn A, et al. Streptococcus suis: a re-emerging pathogen associated with occupational exposure to pigs or pork products. Part II - Pathogenesis. Ann Agric Environ Med. 2018;25:186-203 pubmed publisher
    ..are pathogenicity islands (PAI), in particular, a novel DNA segment of 89 kb length with evident pathogenic traits that has been designated as 89K PAI. It has been estimated that more than one-third of the <i>S...
  7. Udina M, Navines R, Egmond E, Oriolo G, Langohr K, Gimenez D, et al. Glucocorticoid Receptors, Brain-Derived Neurotrophic Factor, Serotonin and Dopamine Neurotransmission are Associated with Interferon-Induced Depression. Int J Neuropsychopharmacol. 2016;19: pubmed publisher
    ..005, HR = 1.13) increased the risk of IFN-induced depression. So too did TCI personality traits, with high scores on fatigability (p = 0.0037, HR = 1.17), impulsiveness (p = 0.0200 HR = 1...
  8. Lieboldt M, Frahm J, Halle I, Görs S, Schrader L, Weigend S, et al. Metabolic and clinical response to Escherichia coli lipopolysaccharide in layer pullets of different genetic backgrounds supplied with graded dietary L-arginine. Poult Sci. 2016;95:595-611 pubmed publisher
    ..The varying grades of Arg did not alter the examined traits named above, whereas insufficient Arg reduced body growth and increased relative weights of liver and pancreas ..
  9. Pantucek R, Sedláček I, Indráková A, Vrbovská V, Mašlaňová I, Kovařovic V, et al. Staphylococcus edaphicus sp. nov., isolated in Antarctica, harbours mecC gene and genomic islands with suspected role in adaptation to extreme environment. Appl Environ Microbiol. 2017;: pubmed publisher
    ..in the Staphylococcus genus with a special focus on antimicrobial resistance, pathogenicity and survival traits. Genes encoded on mobile genetic elements were arranged in unique combinations but retained conserved locations ..

More Information

Publications147 found, 100 shown here

  1. Lacroix C, Richard G, Seguineau C, Guyomarch J, Moraga D, Auffret M. Active and passive biomonitoring suggest metabolic adaptation in blue mussels (Mytilus spp.) chronically exposed to a moderate contamination in Brest harbor (France). Aquat Toxicol. 2015;162:126-37 pubmed publisher
    ..Whether these adaptive traits result from phenotypic plasticity or genetic adaptation needs to be further investigated.
  2. Levato R, Webb W, Otto I, Mensinga A, Zhang Y, van Rijen M, et al. The bio in the ink: cartilage regeneration with bioprintable hydrogels and articular cartilage-derived progenitor cells. Acta Biomater. 2017;61:41-53 pubmed publisher
    ..identification of multipotent articular cartilage-resident chondroprogenitor cells (ACPCs), which share important traits with adult stem cells, represents a new opportunity for cartilage regeneration...
  3. Awad W, Smorodchenko A, Hess C, Aschenbach J, Molnár A, Dublecz K, et al. Increased intracellular calcium level and impaired nutrient absorption are important pathogenicity traits in the chicken intestinal epithelium during Campylobacter jejuni colonization. Appl Microbiol Biotechnol. 2015;99:6431-41 pubmed publisher
    ..Altogether, these findings indicate that Campylobacter is not entirely a commensal and can be recognized as an important factor contributing to an impaired chicken gut health. ..
  4. Waite C, Schumacher J, Jovanovic M, Bennett M, Buck M. Negative Autogenous Control of the Master Type III Secretion System Regulator HrpL in Pseudomonas syringae. MBio. 2017;8: pubmed publisher
    ..employed by pathogens to coordinate virulence and to evade plant defenses is vital for informing crop resistance traits and management strategies...
  5. Burgsdorf I, Slaby B, Handley K, Haber M, Blom J, Marshall C, et al. Lifestyle evolution in cyanobacterial symbionts of sponges. MBio. 2015;6:e00391-15 pubmed publisher
    ..Symbiont genomes shared about half of their total number of coding genes. Common traits of "Ca...
  6. van Gastelen S, Visker M, Edwards J, Antunes Fernandes E, Hettinga K, Alferink S, et al. Linseed oil and DGAT1 K232A polymorphism: Effects on methane emission, energy and nitrogen metabolism, lactation performance, ruminal fermentation, and rumen microbial composition of Holstein-Friesian cows. J Dairy Sci. 2017;100:8939-8957 pubmed publisher
    ..that DGAT1 does not affect enteric CH4 emission and production pathways, but that it does affect traits other than lactation characteristics, including metabolizability, N efficiency, and the relative abundance of ..
  7. Smith A, Bonato M, Dzama K, Malecki I, Cloete S. Mineral profiling of ostrich (Struthio camelus) seminal plasma and its relationship with semen traits and collection day. Anim Reprod Sci. 2018;193:98-106 pubmed publisher
    ..semen volume and seminal plasma volume, was explored as well as the relationships amongst these specific sperm traits and SP minerals...
  8. Bauerová P, Vinklerová J, Hranicek J, Čorba V, Vojtek L, Svobodova J, et al. Associations of urban environmental pollution with health-related physiological traits in a free-living bird species. Sci Total Environ. 2017;601-602:1556-1565 pubmed publisher
    ..This is also supported by traits indicative of anaemia-like haemolytic conditions (decreased absolute erythrocyte count) and increased ..
  9. Abdelrahman H, ElHady M, Alcivar Warren A, Allen S, Al Tobasei R, Bao L, et al. Aquaculture genomics, genetics and breeding in the United States: current status, challenges, and priorities for future research. BMC Genomics. 2017;18:191 pubmed publisher
    ..organization of aquaculture species, and their genomic and phenomic variations, as well as the genetic basis of traits and their interrelationships...
  10. Ghonim M, Pyakurel K, Ju J, Rodriguez P, Lammi M, Davis C, et al. DNA-dependent protein kinase inhibition blocks asthma in mice and modulates human endothelial and CD4⁺ T-cell function without causing severe combined immunodeficiency. J Allergy Clin Immunol. 2015;135:425-40 pubmed publisher
    ..of the 450-kDa catalytic subunit of the kinase (DNA-PKcs(+/-)) also prevented manifestation of asthma-like traits. These results were confirmed in a chronic model of asthma by using house dust mite, a human allergen...
  11. Wang M, Hancock T, Macleod I, Pryce J, Cocks B, Hayes B. Putative enhancer sites in the bovine genome are enriched with variants affecting complex traits. Genet Sel Evol. 2017;49:56 pubmed publisher
    ..Enhancers are key contributors to gene regulation, and causative variants that affect quantitative traits in humans and mice have been located in enhancer regions...
  12. LePage D, Jernigan K, Bordenstein S. The relative importance of DNA methylation and Dnmt2-mediated epigenetic regulation on Wolbachia densities and cytoplasmic incompatibility. Peerj. 2014;2:e678 pubmed publisher
    ..pathway is targeted for modulation during cytoplasmic incompatibility because it accounts for all of these traits. Here we show that infection of the testes is associated with a 55% increase of host DNA methylation in Drosophila ..
  13. Zapata I, Serpell J, Alvarez C. Genetic mapping of canine fear and aggression. BMC Genomics. 2016;17:572 pubmed publisher
    ..We conducted genomewide association (GWA) mapping of breed stereotypes for many fear and aggression traits across several hundred dogs from diverse breeds...
  14. Karakochuk C, Whitfield K, Barr S, Lamers Y, Devlin A, Vercauteren S, et al. Genetic hemoglobin disorders rather than iron deficiency are a major predictor of hemoglobin concentration in women of reproductive age in rural prey Veng, Cambodia. J Nutr. 2015;145:134-42 pubmed publisher
    ..Other predictors were 2 other heterozygous traits (hemoglobin E and Constant Spring), parity, RBP, log ferritin, and vitamin B-12...
  15. Tanner J, Patel P, Hellinga J, Donald L, Jimenez C, LeBlanc J, et al. Legionella pneumophila OxyR Is a Redundant Transcriptional Regulator That Contributes to Expression Control of the Two-Component CpxRA System. J Bacteriol. 2017;199: pubmed publisher
    ..pneumophila OxyR (OxyRLp) has been previously identified as a potential regulator of virulence traits warranting further investigation. This study demonstrated that oxyR is nonessential for L...
  16. Degroote S, Hunting D, Takser L. Periconceptional folate deficiency leads to autism-like traits in Wistar rat offspring. Neurotoxicol Teratol. 2018;66:132-138 pubmed publisher
    ..Maternal periconceptional deficit in folate provokes alterations in the behavior of offspring relevant to the autistic-like phenotype. ..
  17. Doberenz S, Eckweiler D, Reichert O, Jensen V, Bunk B, Sproer C, et al. Identification of a Pseudomonas aeruginosa PAO1 DNA Methyltransferase, Its Targets, and Physiological Roles. MBio. 2017;8: pubmed publisher
    ..gene expression, emphasizing the role of enzymatic DNA methylation as an epigenetic control of phenotypic traits in P...
  18. Singh R, Parihar P, Prasad S. Simultaneous exposure of sulphur and calcium hinder As toxicity: Up-regulation of growth, mineral nutrients uptake and antioxidants system. Ecotoxicol Environ Saf. 2018;161:318-331 pubmed publisher
    ..to this, exogenous application of S, Ca and S + Ca, markedly reduced the negative impact of As on above captioned traits except ProDH activity...
  19. Siracuse B, Gorgy G, Ruskin J, Beebe K. What is the Incidence of Suicide in Patients with Bone and Soft Tissue Cancer? : Suicide and Sarcoma. Clin Orthop Relat Res. 2017;475:1439-1445 pubmed publisher
    ..are associated with higher incidence of suicide, physicians should consider screening patients possessing these traits. By identifying at-risk patients, we can hope to reduce the incidence of suicide in this population by providing ..
  20. von Toerne C, Huth C, de Las Heras Gala T, Kronenberg F, Herder C, Koenig W, et al. MASP1, THBS1, GPLD1 and ApoA-IV are novel biomarkers associated with prediabetes: the KORA F4 study. Diabetologia. 2016;59:1882-92 pubmed publisher
    ..We discovered novel and independent associations of prediabetes and related traits with MASP1, and some evidence for associations with THBS1, GPLD1 and ApoA-IV, suggesting a role for these proteins ..
  21. Hassan F, Mahrose K, Basyony M. Effects of grape seed extract as a natural antioxidant on growth performance, carcass characteristics and antioxidant status of rabbits during heat stress. Arch Anim Nutr. 2016;70:141-54 pubmed publisher
    ..effects of different levels of dietary supplementation of grape seed extract (GSE) on growth performance, carcass traits and antioxidant status of rabbits under heat stress conditions (temperature humidity index 87.5-93.5)...
  22. Favalli V, Disabella E, Molinaro M, Tagliani M, Scarabotto A, Serio A, et al. Genetic Screening of Anderson-Fabry Disease in Probands Referred From Multispecialty Clinics. J Am Coll Cardiol. 2016;68:1037-50 pubmed publisher
    ..Inclusion criteria comprised phenotypical traits and absence of male-to-male transmission. Screening was extended to relatives of probands harboring GLA mutations...
  23. Kobow K, Blumcke I. Epigenetics in epilepsy. Neurosci Lett. 2018;667:40-46 pubmed publisher
    ..or temporal lobe epilepsy with hippocampal sclerosis (TLE-HS), do not seem to primarily associate with hereditary traits, suggesting other pathogenic mechanisms...
  24. Szechyńska Hebda M, Wąsek I, Gołębiowska Pikania G, Dubas E, Żur I, Wędzony M. Photosynthesis-dependent physiological and genetic crosstalk between cold acclimation and cold-induced resistance to fungal pathogens in triticale (Triticosecale Wittm.). J Plant Physiol. 2015;177:30-43 pubmed publisher
    ..b>Traits related to: photosynthesis-dependent cold-acclimation and cold-induced resistance; biomass accumulation and growth;..
  25. Van Tilburg M, Levy R, Walker L, Von Korff M, Feld L, Garner M, et al. Psychosocial mechanisms for the transmission of somatic symptoms from parents to children. World J Gastroenterol. 2015;21:5532-41 pubmed publisher
    ..13, P < 0.05; acceptance rho = 0.13, P < 0.05). Hypothesis 4: mothers and children share psychological traits such as anxiety, depression, and somatization...
  26. Shirer W, Jiang H, Price C, Ng B, Greicius M. Optimization of rs-fMRI Pre-processing for Enhanced Signal-Noise Separation, Test-Retest Reliability, and Group Discrimination. Neuroimage. 2015;117:67-79 pubmed publisher
    ..This tool has been used to examine network changes induced by cognitive and emotional states, neurological traits, and neuropsychiatric disorders...
  27. Muriel J, Pérez Rodríguez L, Puerta M, Gil D. Diverse dose-response effects of yolk androgens on embryo development and nestling growth in a wild passerine. J Exp Biol. 2015;218:2241-9 pubmed publisher
    ..We found that yolk androgens induce a non-linear dose-response pattern in several traits. Androgens had a stimulatory effect on hatchling body mass and nestling skeletal growth, but maximum values were ..
  28. Holaday A, Schwilk D, Waring E, Guvvala H, Griffin C, Lewis O. Plasticity of nitrogen allocation in the leaves of the invasive wetland grass, Phalaris arundinacea and co-occurring Carex species determines the photosynthetic sensitivity to nitrogen availability. J Plant Physiol. 2015;177:20-9 pubmed publisher
    ..Our aim was to address whether morphological and physiological traits associated with carbon gain for P. arundinacea and C...
  29. Pereira E, Collevatti R, Kokubum M, Miranda N, Maciel N. Ancestral reconstruction of reproductive traits shows no tendency toward terrestriality in leptodactyline frogs. BMC Evol Biol. 2015;15:91 pubmed publisher
    ..Correlations among reproductive modes and other life-history traits suggested that tadpole environment, clutch size, nuptial spines, and egg pigmentation were co-evolving and driven ..
  30. Johnson J, Johnston B, Kuskowski M, Sokurenko E, Tchesnokova V. Intensity and Mechanisms of Fluoroquinolone Resistance within the H30 and H30Rx Subclones of Escherichia coli Sequence Type 131 Compared with Other Fluoroquinolone-Resistant E. coli. Antimicrob Agents Chemother. 2015;59:4471-80 pubmed publisher
    ..coli strains. This urges both parsimonious fluoroquinolone use and a search for other fitness-enhancing traits within ST131 H30.
  31. Vicente M, Zsögön A, de Sá A, Ribeiro R, Peres L. Semi-determinate growth habit adjusts the vegetative-to-reproductive balance and increases productivity and water-use efficiency in tomato (Solanum lycopersicum). J Plant Physiol. 2015;177:11-9 pubmed publisher
    ..growth habit to characterize semi-determinate growth and to determine its impact on developmental and productivity traits. We show that semi-determinate genotypes are equivalent to determinate ones with extended vegetative growth, which ..
  32. Minică C, Dolan C, Hottenga J, Pool R, Fedko I, Mbarek H, et al. Heritability, SNP- and Gene-Based Analyses of Cannabis Use Initiation and Age at Onset. Behav Genet. 2015;45:503-13 pubmed publisher
    ..lt;1 % explained variance) and are uniformly distributed over the genome in proportion to chromosomes' length. Similar to other complex traits and diseases, detecting such small effects is to be expected in sufficiently large samples.
  33. Yen C, Yeh Y, Liang C, Ho P, Kuo S, Huang C, et al. Reduced Dopamine Transporter Availability and Neurocognitive Deficits in Male Patients with Alcohol Dependence. PLoS ONE. 2015;10:e0131017 pubmed publisher
    ..Personality Questionnaire (TPQ) were administered to assess neurocognitive functioning and personality traits, respectively...
  34. Sullivan P, Agrawal A, Bulik C, Andreassen O, Børglum A, Breen G, et al. Psychiatric Genomics: An Update and an Agenda. Am J Psychiatry. 2018;175:15-27 pubmed publisher
    ..These findings are likely to elucidate the genetic portions of these truly complex traits, and this knowledge can then be mined for its relevance for improved therapeutics and its impact on psychiatric ..
  35. Jain L, Rawat M, Prajapati A, Tiwari A, Kumar B, Chaturvedi V, et al. Protective immune-response of aluminium hydroxide gel adjuvanted phage lysate of Brucella abortus S19 in mice against direct virulent challenge with B. abortus 544. Biologicals. 2015;43:369-76 pubmed publisher
    ..lysate methodology provides a very viable option through which an improved immunizing preparation with all desirable traits can be developed against brucellosis, and integrated with immunization programmes in a more efficient manner.
  36. Scheper C, Wensch Dorendorf M, Yin T, Dressel H, Swalve H, König S. Evaluation of breeding strategies for polledness in dairy cattle using a newly developed simulation framework for quantitative and Mendelian traits. Genet Sel Evol. 2016;48:50 pubmed publisher
    ..pool of genetically-closely related artificial insemination sires with lower breeding values for performance traits raises questions regarding the effects of intensified selection based on this founder pool...
  37. Mackenzie R, Dowell J, Ayansina D, Cleland J. Do personality traits assessed on medical school admission predict exit performance? A UK-wide longitudinal cohort study. Adv Health Sci Educ Theory Pract. 2017;22:365-385 pubmed publisher
    Traditional methods of assessing personality traits in medical school selection have been heavily criticised...
  38. Liu G, Zhao Y, Mirdita V, Reif J. Efficient strategies to assess yield stability in winter wheat. Theor Appl Genet. 2017;130:1587-1599 pubmed publisher
    ..performance and yield stability of wheat hybrids and inbred lines, (3) investigate the association of agronomic traits with yield stability, and (4) explore the possibility of selecting subsets of environments allowing to portray ..
  39. Vila Aiub M, Yu Q, Han H, Powles S. Effect of herbicide resistance endowing Ile-1781-Leu and Asp-2078-Gly ACCase gene mutations on ACCase kinetics and growth traits in Lolium rigidum. J Exp Bot. 2015;66:4711-8 pubmed publisher
    The rate of herbicide resistance evolution in plants depends on fitness traits endowed by alleles in both the presence and absence (resistance cost) of herbicide selection...
  40. Gisbert C, Dabauza M, Correal E, Swennen R, Panis B. Cryopreservation of Bituminaria bituminosa varieties and hybrids. Cryobiology. 2015;71:279-85 pubmed publisher
    ..Bituminaria breeding programs aim to develop and conserve hybrids with desirable traits such as high forage quality, tolerance to biotic or abiotic stresses, and high contents of furanocoumarins...
  41. Ivković M, Gračan R, Horvat B. Croatian aquatic dance flies (Diptera: Empididae: Clinocerinae and Hemerodromiinae): species diversity, distribution and relationship to surrounding countries. Zootaxa. 2013;3686:255-76 pubmed
    ..is presented, including information related to the Ecoregions in which species were found and specific species traits. Clinocerinae are represented by five genera, with Wiedemannia Zetterstedt being most species rich (20 species) ..
  42. Li J, Wang Z, Li R, Wu R. BAYESIAN GROUP LASSO FOR NONPARAMETRIC VARYING-COEFFICIENT MODELS WITH APPLICATION TO FUNCTIONAL GENOME-WIDE ASSOCIATION STUDIES. Ann Appl Stat. 2015;9:640-664 pubmed
    ..genome-wide association studies (GWAS) have proven powerful for comprehending the genetic architecture of complex traits, they are challenged by a high dimension of single-nucleotide polymorphisms (SNPs) as predictors, the presence of ..
  43. Fetzer I, Johst K, Schäwe R, Banitz T, Harms H, Chatzinotas A. The extent of functional redundancy changes as species' roles shift in different environments. Proc Natl Acad Sci U S A. 2015;112:14888-93 pubmed publisher
    ..It also implies that species richness is important because it provides a pool of species with potentially relevant traits. These species may turn out to be essential performers or partners in new interspecific interactions after ..
  44. Mollaret P, Miraucourt D. Is job performance independent from career success? A conceptual distinction between competence and agency. Scand J Psychol. 2016;57:607-617 pubmed publisher
    ..to social judgment, we conducted five studies to validate a conceptual distinction between agency and competence traits. Studies 1-3 revealed that competence traits (e.g...
  45. Avila L, Perez C, Minoli I, Medina C, Sites J, Morando M. New species of <i>Liolaemus</i> (Reptilia, Squamata, Liolaemini) of the <i>Liolaemus</i> <i>donosobarrosi</i> clade from northwestern Patagonia, Neuquén province, Argentina. Zootaxa. 2017;4362:535-563 pubmed publisher
    ..differ from other members of their clade by a combination of coloration characters, morphometric and molecular traits. Liolaemus tirantii sp. nov...
  46. Dasse M, Elkins G, Weaver C. Correlates of the multidimensional construct of hypnotizability: paranormal belief, fantasy proneness, magical ideation, and dissociation. Int J Clin Exp Hypn. 2015;63:274-83 pubmed publisher
    ..The findings demonstrate the influence of fantasy proneness and magical thinking on hypnotizability and support the theory that hypnotizability is a complex interaction of multiple traits.
  47. Pampel F, Boardman J, Daw J, Stallings M, Smolen A, Haberstick B, et al. Life events, genetic susceptibility, and smoking among adolescents. Soc Sci Res. 2015;54:221-32 pubmed publisher
    ..are associated with the adoption of unhealthy behaviors such as smoking, both social circumstances and physical traits can moderate the relationship...
  48. Domec J, Smith D, McCulloh K. A synthesis of the effects of atmospheric carbon dioxide enrichment on plant hydraulics: implications for whole-plant water use efficiency and resistance to drought. Plant Cell Environ. 2017;40:921-937 pubmed publisher
    ..Further, changes in drought-resistance traits suggest that non-woody plants were the most affected by CO2e , which may permit them to ..
  49. Shahid S, Rehman A. Association Patterns of Endothelial Nitric Oxide Synthase Gene (NOS3) Variant Glu298Asp with Blood Pressure and Serum Lipid Levels in Subjects with Coronary Artery Disease from Pakistan. Ann Hum Genet. 2017;81:129-134 pubmed publisher
    ..9%, P?=?0.28) and risk allele was not associated with CAD (OR 1.15 (0.86-1.54), P?=?0.33) and the tested lipid traits but had a strong association with blood pressure (for systolic and diastolic P?=?1...
  50. Saino N, Romano M, Rubolini D, Ambrosini R, Caprioli M, Milzani A, et al. Viability is associated with melanin-based coloration in the barn swallow (Hirundo rustica). PLoS ONE. 2013;8:e60426 pubmed publisher
    ..Genes responsible for eu- or pheomelanogenesis have pleiotropic but contrasting effects on life-history traits, explaining the patterns of covariation observed between melanization and physiology (e.g...
  51. Schouws S, Paans N, Comijs H, Dols A, Stek M. Coping and personality in older patients with bipolar disorder. J Affect Disord. 2015;184:67-71 pubmed publisher
    Little is known about coping styles and personality traits in older bipolar patients. Adult bipolar patients show a passive coping style and higher neuroticism scores compared to the general population...
  52. Teumer A, Qi Q, Nethander M, Aschard H, Bandinelli S, Beekman M, et al. Genomewide meta-analysis identifies loci associated with IGF-I and IGFBP-3 levels with impact on age-related traits. Aging Cell. 2016;15:811-24 pubmed publisher
  53. Riordan J, Nadeau J. From Peas to Disease: Modifier Genes, Network Resilience, and the Genetics of Health. Am J Hum Genet. 2017;101:177-191 pubmed publisher
    ..of modifier genetics and assess progress in studies of modifier genes and their targets in both simple and complex traits. We propose that modifier effects emerge from gene interaction networks whose structure and function vary with ..
  54. Kadiene E, Bialais C, Ouddane B, Hwang J, Souissi S. Differences in lethal response between male and female calanoid copepods and life cycle traits to cadmium toxicity. Ecotoxicology. 2017;26:1227-1239 pubmed publisher
    ..In addition, the effect of Cd to their life cycle traits was quantified...
  55. Chong G, Kimyon O, Manefield M. Quorum Sensing Signal Synthesis May Represent a Selective Advantage Independent of Its Role in Regulation of Bioluminescence in Vibrio fischeri. PLoS ONE. 2013;8:e67443 pubmed publisher
    The evolution of biological signalling systems and apparently altruistic or cooperative traits in diverse organisms has required selection against the subversive tendencies of self-interested biological entities...
  56. Tan L, Wang Z, Wu K, Chen X, Zhu H, Lu S, et al. Bivariate Genome-Wide Association Study Implicates ATP6V1G1 as a Novel Pleiotropic Locus Underlying Osteoporosis and Age at Menarche. J Clin Endocrinol Metab. 2015;100:E1457-66 pubmed publisher
    ..The findings enhance our knowledge of genetic associations between BMD and AAM and provide a rationale for subsequent functional studies of these implicated genes in the pathophysiology of diseases/traits, such as osteoporosis and AAM.
  57. VanWagoner T, Atack J, Nelson K, Smith H, Fox K, Jennings M, et al. The modA10 phasevarion of nontypeable Haemophilus influenzae R2866 regulates multiple virulence-associated traits. Microb Pathog. 2016;92:60-67 pubmed publisher
    ..We conclude that loss of ModA10 function in strain R2866 enhances colonization and invasion by increasing expression of genes that allow for increased adherence, which can contribute to the increased virulence of this strain. ..
  58. Jeong J, Park B, Park H, Choi I, Kim K. Draft Genome Sequence of Chryseobacterium sp. Strain GSE06, a Biocontrol Endophytic Bacterium Isolated from Cucumber (Cucumis sativus). Genome Announc. 2016;4: pubmed publisher
    ..Here, we present its draft genome sequence, which contains genes related to biocontrol traits, such as colonization, antimicrobial activity, plant growth promotion, and abiotic or biotic stress adaptation.
  59. González Tokman D, Martínez M I, Villalobos Ávalos Y, Munguía Steyer R, Ortiz Zayas M, Cruz Rosales M, et al. Ivermectin alters reproductive success, body condition and sexual trait expression in dung beetles. Chemosphere. 2017;178:129-135 pubmed publisher
    ..to different concentrations of ivermectin in the food and evaluated reproductive success and the expression of traits associated with survival and reproduction under laboratory conditions...
  60. Palmer Young E, Calhoun A, Mirzayeva A, Sadd B. Effects of the floral phytochemical eugenol on parasite evolution and bumble bee infection and preference. Sci Rep. 2018;8:2074 pubmed publisher
    ..However, infection-induced dietary shifts could influence pollinator-mediated selection on floral traits.
  61. Hintsa T, Wesolowska K, Elovainio M, Strelau J, Pulkki Råback L, Keltikangas Järvinen L. Associations of temporal and energetic characteristics of behavior with depressive symptoms: A population-based longitudinal study within Strelau's Regulative Theory of Temperament. J Affect Disord. 2016;197:196-204 pubmed publisher
    ..The direction of the association has been found to be sometimes reciprocal. We examined whether temperament traits are associated with depressive symptoms and whether depressive symptoms contribute to changes in temperament...
  62. Rotini A, Martínez Sarrà E, Pozzo E, Sampaolesi M. Interactions between microRNAs and long non-coding RNAs in cardiac development and repair. Pharmacol Res. 2018;127:58-66 pubmed publisher
    ..miRs and lncRNAs are able to post-transcriptionally regulate many genes and bring into play several traits simultaneously due to a myriad of different targets...
  63. Sheard L, Jackson C, Lawton R. How is success achieved by individuals innovating for patient safety and quality in the NHS?. BMC Health Serv Res. 2017;17:640 pubmed publisher
    ..We have uncovered that innovators have particular personal traits which encourage a propensity towards change and action...
  64. Sulayman A, Tursun M, Sulaiman Y, Huang X, Tian K, Tian Y, et al. Association analysis of polymorphisms in six KRT genes with wool traits in sheep. Asian-Australas J Anim Sci. 2017;: pubmed publisher
    The purpose of this study was to investigate the genetic effects of six KRT genes on the wool traits of 418 Chinese Merino (Xinjiang type) (CMXT) individuals.
  65. Maor R, Dayan T, Ferguson Gow H, Jones K. Temporal niche expansion in mammals from a nocturnal ancestor after dinosaur extinction. Nat Ecol Evol. 2017;1:1889-1895 pubmed publisher
    ..While ancestral reconstructions of behavioural traits from extant species have the potential to elucidate these patterns, existing studies have been limited in ..
  66. Oyserman B, Medema M, Raaijmakers J. Road MAPs to engineer host microbiomes. Curr Opin Microbiol. 2018;43:46-54 pubmed publisher
    ..Thus far, investigations into these emergent traits, referred to here as microbiome-associated phenotypes (MAPs), have been primarily qualitative and taxonomy-driven ..
  67. Ruíz Masó J, Luengo L, Moreno Córdoba I, Díaz Orejas R, del Solar G. Successful Establishment of Plasmids R1 and pMV158 in a New Host Requires the Relief of the Transcriptional Repression of Their Essential rep Genes. Front Microbiol. 2017;8:2367 pubmed publisher
    Although differing in size, encoded traits, host range, and replication mechanism, both narrow-host-range theta-type conjugative enterobacterial plasmid R1 and promiscuous rolling-circle-type mobilizable streptococcal plasmid pMV158 ..
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    ..1) All traits were significantly influenced by the interaction of population and growth condition and by population in ..
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    ..Platelet MAO-B activity has been associated with psychopathy- and aggression-related personality traits, while variants of the MAOA and MAOB genes have been associated with diverse clinical phenotypes, including ..
  72. Pham N, Iyer S, Hackett E, Lock B, Sandy M, Zeise L, et al. Using ToxCast to Explore Chemical Activities and Hazard Traits: A Case Study With Ortho-Phthalates. Toxicol Sci. 2016;151:286-301 pubmed publisher
    ..This study revealed several links between key molecular events assayed in vitro and chemical-specific hazard traits. In general, parent o-phthalates are more active than their monoester metabolites...
  73. Silva L, Batista R, Anjos R, Souza M, Carneiro P, Souza T, et al. Morphoagronomic characterization and genetic diversity of a common bean RIL mapping population derived from the cross Rudá x AND 277. Genet Mol Res. 2016;15: pubmed publisher
    ..in the RILs is essential for detecting associations between molecular markers and loci controlling agronomic traits of interest...
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    ..of dolichol can, however, be distinguished on the basis of their length, degree of saturation and by other traits. As is true for many facets of their biology, Archaea, best known in their capacity as extremophiles, present ..
  75. Ramos Lopez O, Riezu Boj J, Milagro F, Martinez J. DNA methylation signatures at endoplasmic reticulum stress genes are associated with adiposity and insulin resistance. Mol Genet Metab. 2018;123:50-58 pubmed publisher
    ..aim of this study was to analyze the association of DNA methylation signatures at ER stress genes with adiposity traits and related metabolic disorders...
  76. Cheng G, Liu Y, Chan C, So K, Zeng H, Lee T. Neurobiological underpinnings of sensation seeking trait in heroin abusers. Eur Neuropsychopharmacol. 2015;25:1968-80 pubmed publisher
    ..Psychologically, personality traits related to reward processing and cognitive control differed between heroin abusers and non-abusers...
  77. Baer B, Millar A. Proteomics in evolutionary ecology. J Proteomics. 2016;135:4-11 pubmed publisher
    Evolutionary ecologists are traditionally gene-focused, as genes propagate phenotypic traits across generations and mutations and recombination in the DNA generate genetic diversity required for evolutionary processes...
  78. Ben Brahim S, Kelebek H, Ammar S, Abichou M, Bouaziz M. LC-MS phenolic profiling combined with multivariate analysis as an approach for the characterization of extra virgin olive oils of four rare Tunisian cultivars during ripening. Food Chem. 2017;229:9-19 pubmed publisher
    ..Furthermore, some agronomical traits were determined in which a general increase in the size of the fruit and oil contents were recorded for all ..
  79. Makarowski R, Piotrowski A. [The psychological profile of pilots of passenger planes: Analysis of temperamental traits, aggression and risk]. Med Pr. 2017;68:639-651 pubmed publisher
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    ..studies have made great strides toward the detection of genes and genetic mechanisms underlying complex traits. However, the majority of associated loci reside in non-coding regions that are functionally uncharacterized in ..
  81. Dong T, Duan B, Zhang S, Korpelainen H, Niinemets U, Li C. Growth, biomass allocation and photosynthetic responses are related to intensity of root severance and soil moisture conditions in the plantation tree Cunninghamia lanceolata. Tree Physiol. 2016;36:807-17 pubmed publisher
    ..Yet, all these traits except L/FR and foliage nitrogen content were severely reduced under 75% pruning...
  82. Bernal J, Dávila Flores A, Medina R, Chen Y, Harrison K, Berrier K. Did maize domestication and early spread mediate the population genetics of Corn leafhopper?. Insect Sci. 2017;: pubmed publisher
    ..Crop domestication generally involved artificial selection for traits desirable to early farmers, e.g...
  83. Matros A, Liu G, Hartmann A, Jiang Y, Zhao Y, Wang H, et al. Genome-metabolite associations revealed low heritability, high genetic complexity, and causal relations for leaf metabolites in winter wheat (Triticum aestivum). J Exp Bot. 2017;68:415-428 pubmed publisher
    ..Genome-wide association studies identified significant associations for six metabolic traits, namely oxalic acid, ornithine, L-arginine, pentose alcohol III, L-tyrosine, and a sugar oligomer (oligo II), with ..
  84. Hughson B, Anreiter I, Jackson Chornenki N, Murphy K, Ja W, Huber R, et al. The adult foraging assay (AFA) detects strain and food-deprivation effects in feeding-related traits of Drosophila melanogaster. J Insect Physiol. 2018;106:20-29 pubmed publisher
    ..the AFA by taking advantage of established rover and sitter strains known to differ in a number of feeding-related traits. The AFA allows us to effectively distinguish locomotor behavior in Fed and Food-Deprived (FD) rover and sitter ..
  85. Anholt R, Mackay T. The road less traveled: from genotype to phenotype in flies and humans. Mamm Genome. 2018;29:5-23 pubmed publisher
    ..flies, has enabled genome-wide association studies of morphological, physiological, behavioral, and life history traits, and demonstrated that genetic architectures of complex traits are highly polygenic, sexually dimorphic, and ..
  86. Henry Y, Renault D, Colinet H. Hormesis-like effect of mild larval crowding on thermotolerance in Drosophila flies. J Exp Biol. 2018;221: pubmed publisher
    ..Here, we evaluated the effect of larval density on several biological traits of Drosophila melanogaster An increasing gradient, from 1 to 1000 eggs per milliliter of food, was used to ..
  87. de Jong I, van Leeuwen O, Lisman T, Gouw A, Porte R. Repopulating the biliary tree from the peribiliary glands. Biochim Biophys Acta Mol Basis Dis. 2018;1864:1524-1531 pubmed publisher
    ..Moreover, PBG have been identified as niches of multipotent stem/progenitor cells with endodermal lineage traits. This has sparked research interest in the role of PBG in the pathogenesis of various cholangiopathies as well as ..
  88. Tao W, Li Y, Yang H, Song M, Lu Y, Li W. Widespread Occurrence of Zoonotic Cryptosporidium Species and Subtypes in Dairy Cattle from Northeast China: Public Health Concerns. J Parasitol. 2017;: pubmed publisher
    ..In the present study we investigated dairy cattle of all ages in northeast China for the prevalence and genetic traits of Cryptosporidium...
  89. Brikmanis K, Petersen A, Doran N. Do personality traits related to affect regulation predict other tobacco product use among young adult non-daily smokers?. Addict Behav. 2017;75:79-84 pubmed publisher
    ..The goal of this study was to test the hypothesis that personality traits related to affect regulation would be associated with greater frequency of other tobacco product (OTP) use in a ..
  90. Norman A, Taylor J, Tanaka E, Telfer P, Edwards J, Martinant J, et al. Increased genomic prediction accuracy in wheat breeding using a large Australian panel. Theor Appl Genet. 2017;130:2543-2555 pubmed publisher
    ..to investigate the accuracy of genomic prediction for grain yield, physical grain quality and other physiological traits. To achieve this, the complete panel was phenotyped in a dedicated field trial and genotyped using a custom Axiom<..
  91. Potvin D. Coping with a changing soundscape: avoidance, adjustments and adaptations. Anim Cogn. 2017;20:9-18 pubmed publisher
    ..I will be highlighting current gaps in our knowledge, such as how noise might impact behavioural traits such as predation, as well as how noise causes physical damage to neurotransmitters and affects stress levels, in ..
  92. Meyer M, Neff P, Liem F, Kleinjung T, Weidt S, Langguth B, et al. Differential tinnitus-related neuroplastic alterations of cortical thickness and surface area. Hear Res. 2016;342:1-12 pubmed publisher
    ..has meanwhile been identified as a neuroanatomical measurement that confounds genetically distinct neuroanatomical traits, namely cortical thickness (CT) and cortical surface area (CSA)...