DDIT3

Summary

Gene Symbol: DDIT3
Description: DNA damage inducible transcript 3
Alias: C/EBPzeta, CEBPZ, CHOP, CHOP-10, CHOP10, GADD153, DNA damage-inducible transcript 3 protein, C/EBP zeta, CCAAT/enhancer-binding protein homologous protein, c/EBP-homologous protein 10, growth arrest and DNA damage-inducible protein GADD153
Species: human
Products:     DDIT3

Top Publications

  1. Qian J, Chen Z, Lin J, Wang W, Cen J. Decreased expression of CCAAT/enhancer binding protein zeta (C/EBPzeta) in patients with different myeloid diseases. Leuk Res. 2005;29:1435-41 pubmed
    ..C/EBPzeta, also known as GADD153, CHOP10, and DDIT3 has been found associated with the development of myxoid liposarcoma and the progression of ..
  2. Rabbitts T, Forster A, Larson R, Nathan P. Fusion of the dominant negative transcription regulator CHOP with a novel gene FUS by translocation t(12;16) in malignant liposarcoma. Nat Genet. 1993;4:175-80 pubmed
    ..We show that the translocation t(12;16)(q13:p11) in malignant myxoid liposarcoma can be a fusion of the CHOP dominant negative transcription factor gene with a novel gene, FUS, which can result in fusion of the FUS glycine-..
  3. Goransson M, Andersson M, Forni C, Stahlberg A, Andersson C, Olofsson A, et al. The myxoid liposarcoma FUS-DDIT3 fusion oncoprotein deregulates NF-kappaB target genes by interaction with NFKBIZ. Oncogene. 2009;28:270-8 pubmed publisher
    ..The FUS-DDIT3 fusion oncogene results from a t(12;16)(q13;p11) chromosome translocation and has a causative role in the ..
  4. Oh Y, Liu X, Yue P, Kang S, Chen J, Taunton J, et al. ERK/ribosomal S6 kinase (RSK) signaling positively regulates death receptor 5 expression through co-activation of CHOP and Elk1. J Biol Chem. 2010;285:41310-9 pubmed publisher
    ..Both C/EBP homologous protein (CHOP) and Elk1 are required for celecoxib-induced DR5 expression based on promoter deletion and mutation analysis and ..
  5. Woo C, Cui D, Arellano J, Dorweiler B, Harding H, Fitzgerald K, et al. Adaptive suppression of the ATF4-CHOP branch of the unfolded protein response by toll-like receptor signalling. Nat Cell Biol. 2009;11:1473-80 pubmed publisher
    ..protein response (UPR) restores equilibrium to the ER, but prolonged expression of the UPR effector CHOP (GADD153) is cytotoxic...
  6. Park J, Luethy J, Wang M, Fargnoli J, Fornace A, McBride O, et al. Isolation, characterization and chromosomal localization of the human GADD153 gene. Gene. 1992;116:259-67 pubmed
    We report the isolation and characterization of the growth arrest and DNA-damage-inducible gene, GADD153, from human cells and show that it is localized in the region 12q13.1-q13.2 on chromosome 12...
  7. Kwok S, Daskal I. Brefeldin A activates CHOP promoter at the AARE, ERSE and AP-1 elements. Mol Cell Biochem. 2008;319:203-8 pubmed publisher
    ..RT-PCR analyses showed up-regulation of CHOP/GADD153 and splicing of XBP-1 mRNA in brefeldin A-treated cells...
  8. Scott D, Loo G. Curcumin-induced GADD153 gene up-regulation in human colon cancer cells. Carcinogenesis. 2004;25:2155-64 pubmed
    ..could be responsive to the DNA damage in curcumin-treated cells, growth arrest and DNA damage-inducible gene 153 (GADD153) was considered...
  9. You K, Liu M, Han X, Lee Z, Kim D. Transcriptional regulation of the human transferrin gene by GADD153 in hepatoma cells. Hepatology. 2003;38:745-55 pubmed
    The transcription factor CHOP/GADD153 is reportedly induced by cellular stresses such as UV light, genotoxic agents, and protein misfolding in the endoplasmic reticulum...

More Information

Publications78

  1. Qiao D, Im E, Qi W, Martinez J. Activator protein-1 and CCAAT/enhancer-binding protein mediated GADD153 expression is involved in deoxycholic acid-induced apoptosis. Biochim Biophys Acta. 2002;1583:108-16 pubmed
    ..In this study, we examined the effect of DCA on the GADD153 (growth arrest- and DNA damage-inducible gene 153) proapoptotic gene and its role in DCA-induced apoptosis in a ..
  2. Gotoh T, Oyadomari S, Mori K, Mori M. Nitric oxide-induced apoptosis in RAW 264.7 macrophages is mediated by endoplasmic reticulum stress pathway involving ATF6 and CHOP. J Biol Chem. 2002;277:12343-50 pubmed
    ..On the other hand, mRNA and protein for CHOP, a transcription factor known to be induced by endoplasmic reticulum (ER) stress, were induced...
  3. Jousse C, Bruhat A, Carraro V, Urano F, Ferrara M, Ron D, et al. Inhibition of CHOP translation by a peptide encoded by an open reading frame localized in the chop 5'UTR. Nucleic Acids Res. 2001;29:4341-51 pubmed
    b>Chop is a ubiquitously expressed mammalian gene encoding a small nuclear protein related to the CCAAT/enhancer-binding protein (C/EBP) family of transcription factors...
  4. Chen Y, Tan B, Cheng Y, Chen J, Lee S. Differential regulation of CHOP translation by phosphorylated eIF4E under stress conditions. Nucleic Acids Res. 2010;38:764-77 pubmed publisher
    ..b>CHOP, a downstream transcriptional target of stress-induced ATF4, is also regulated translationally in a uORF-dependent ..
  5. Ubeda M, Vallejo M, Habener J. CHOP enhancement of gene transcription by interactions with Jun/Fos AP-1 complex proteins. Mol Cell Biol. 1999;19:7589-99 pubmed
    The transcription factor CHOP (C/EBP homologous protein 10) is a bZIP protein induced by a variety of stimuli that evoke cellular stress responses and has been shown to arrest cell growth and to promote programmed cell death...
  6. Alter J, Bengal E. Stress-induced C/EBP homology protein (CHOP) represses MyoD transcription to delay myoblast differentiation. PLoS ONE. 2011;6:e29498 pubmed publisher
    ..the ? subunit of the translation initiation factor 2 (eIF2?) is followed by expression of C/EBP homology protein (CHOP) in some myoblasts...
  7. Crozat A, Aman P, Mandahl N, Ron D. Fusion of CHOP to a novel RNA-binding protein in human myxoid liposarcoma. Nature. 1993;363:640-4 pubmed
    ..translocation, t(12;16)(q13;p11), that is associated with a structural rearrangement of the gene encoding CHOP, a growth arrest and DNA-damage inducible member of the C/EBP family of transcription factors residing on 12q13.1...
  8. Jauhiainen A, Thomsen C, Strömbom L, Grundevik P, Andersson C, Danielsson A, et al. Distinct cytoplasmic and nuclear functions of the stress induced protein DDIT3/CHOP/GADD153. PLoS ONE. 2012;7:e33208 pubmed publisher
    DDIT3, also known as GADD153 or CHOP, encodes a basic leucine zipper transcription factor of the dimer forming C/EBP family...
  9. Park S, Choi H, Yang H, Do K, Kim J, Lee D, et al. Endoplasmic reticulum stress-activated C/EBP homologous protein enhances nuclear factor-kappaB signals via repression of peroxisome proliferator-activated receptor gamma. J Biol Chem. 2010;285:35330-9 pubmed publisher
    ..ER stress mediators, including CCAAT enhancer-binding protein (C/EBP) homologous protein (CHOP), are elevated in intestinal epithelia from patients with inflammatory bowel diseases...
  10. Gow A, Wrabetz L. CHOP and the endoplasmic reticulum stress response in myelinating glia. Curr Opin Neurobiol. 2009;19:505-10 pubmed publisher
    ..studies conclude that this stress response is adaptive but, nevertheless, includes maladaptive programs involving CHOP expression that drives cell-autonomous apoptosis...
  11. Palam L, Baird T, Wek R. Phosphorylation of eIF2 facilitates ribosomal bypass of an inhibitory upstream ORF to enhance CHOP translation. J Biol Chem. 2011;286:10939-49 pubmed publisher
    ..One ISR target gene encodes the transcriptional regulator CHOP whose accumulation is critical for stress-induced apoptosis...
  12. Su N, Kilberg M. C/EBP homology protein (CHOP) interacts with activating transcription factor 4 (ATF4) and negatively regulates the stress-dependent induction of the asparagine synthetase gene. J Biol Chem. 2008;283:35106-17 pubmed publisher
    C/EBP homology protein (CHOP), a stress-induced transcription factor, is involved in transcriptional regulation, cell cycle, and apoptosis...
  13. Gragnoli C. CHOP T/C and C/T haplotypes contribute to early-onset type 2 diabetes in Italians. J Cell Physiol. 2008;217:291-5 pubmed publisher
    ..The chromosome 12q13.1 region is in linkage to T2D in different populations, including our Italian dataset. CHOP is a candidate gene for the linkage, as it is located in the chromosome 12q13...
  14. Singh V, Pacheco I, Uversky V, Smith S, Macleod R, Jia Z. Intrinsically disordered human C/EBP homologous protein regulates biological activity of colon cancer cells during calcium stress. J Mol Biol. 2008;380:313-26 pubmed publisher
    ..The C/EBP homologous protein (CHOP) is a proto-oncogene, traditionally shown as a dominant-negative inhibitor of C/EBPs and a transcriptional ..
  15. Tagawa Y, Hiramatsu N, Kasai A, Hayakawa K, Okamura M, Yao J, et al. Induction of apoptosis by cigarette smoke via ROS-dependent endoplasmic reticulum stress and CCAAT/enhancer-binding protein-homologous protein (CHOP). Free Radic Biol Med. 2008;45:50-9 pubmed publisher
    ..Exposure of hBEC to CS or CS extract (CSE) caused expression of endogenous ER stress markers GRP78 and CHOP and induction of apoptosis evidenced by nuclear condensation, membrane blebbing, and activation of caspase-3 and ..
  16. Bento C, Andersson M, Aman P. DDIT3/CHOP and the sarcoma fusion oncoprotein FUS-DDIT3/TLS-CHOP bind cyclin-dependent kinase 2. BMC Cell Biol. 2009;10:89 pubmed publisher
    The DDIT3 gene encodes a transcription factor belonging to the CCAAT/enhancer binding protein (C/EBP) family...
  17. Engström K, Willen H, Kåbjörn Gustafsson C, Andersson C, Olsson M, Göransson M, et al. The myxoid/round cell liposarcoma fusion oncogene FUS-DDIT3 and the normal DDIT3 induce a liposarcoma phenotype in transfected human fibrosarcoma cells. Am J Pathol. 2006;168:1642-53 pubmed
    ..Most MLS/RCLS carry a t(12;16) translocation, resulting in a FUS-DDIT3 fusion gene...
  18. Ron D, Habener J. CHOP, a novel developmentally regulated nuclear protein that dimerizes with transcription factors C/EBP and LAP and functions as a dominant-negative inhibitor of gene transcription. Genes Dev. 1992;6:439-53 pubmed
    ..domain "zipper probe" was used to isolate a clone that encodes a new C/EBP-homologous protein: CHOP-10...
  19. Chen B, Wolfgang C, Hai T. Analysis of ATF3, a transcription factor induced by physiological stresses and modulated by gadd153/Chop10. Mol Cell Biol. 1996;16:1157-68 pubmed
    ..We also demonstrate that an ATF3-interacting protein, gadd153/Chop10, forms a nonfunctional heterodimer with ATF3: the heterodimer, in contrast to the ATF3 homodimer, does not ..
  20. Panagopoulos I, Hoglund M, Mertens F, Mandahl N, Mitelman F, Aman P. Fusion of the EWS and CHOP genes in myxoid liposarcoma. Oncogene. 1996;12:489-94 pubmed
    ..t(12;16)(q13;p11), which cytogenetically characterizes myxoid liposarcomas (MLS), results in a fusion of the CHOP gene in 12q13 and the FUS gene in 16p11, creating a chimeric FUS/CHOP gene...
  21. Yamaguchi H, Wang H. CHOP is involved in endoplasmic reticulum stress-induced apoptosis by enhancing DR5 expression in human carcinoma cells. J Biol Chem. 2004;279:45495-502 pubmed
    ..Here, we provide evidence that CHOP is involved in THG up-regulation of DR5, which is a critical step for ER stress-induced apoptosis in human cancer ..
  22. Wang X, Ron D. Stress-induced phosphorylation and activation of the transcription factor CHOP (GADD153) by p38 MAP Kinase. Science. 1996;272:1347-9 pubmed
    b>CHOP, a member of the C/EBP family of transcription factors, mediates effects of cellular stress on growth and differentiation...
  23. Cui K, Coutts M, Stahl J, Sytkowski A. Novel interaction between the transcription factor CHOP (GADD153) and the ribosomal protein FTE/S3a modulates erythropoiesis. J Biol Chem. 2000;275:7591-6 pubmed
    The transcription factor CHOP (GADD153) heterodimerizes with other C/EBP family members, especially C/EBPbeta, thus preventing their homodimerization and binding to DNA sequences specific for the homodimers...
  24. Averous J, Bruhat A, Jousse C, Carraro V, Thiel G, Fafournoux P. Induction of CHOP expression by amino acid limitation requires both ATF4 expression and ATF2 phosphorylation. J Biol Chem. 2004;279:5288-97 pubmed
    The CHOP gene is transcriptionally induced by amino acid starvation...
  25. Dezwaan McCabe D, Riordan J, Arensdorf A, Icardi M, Dupuy A, Rutkowski D. The stress-regulated transcription factor CHOP promotes hepatic inflammatory gene expression, fibrosis, and oncogenesis. PLoS Genet. 2013;9:e1003937 pubmed publisher
    ..Here we provide multiple lines of evidence demonstrating that the ISR-regulated transcription factor CHOP promotes liver cancer...
  26. Rodriguez R, Rubio R, Gutierrez Aranda I, Melen G, Elosua C, Garcia Castro J, et al. FUS-CHOP fusion protein expression coupled to p53 deficiency induces liposarcoma in mouse but not in human adipose-derived mesenchymal stem/stromal cells. Stem Cells. 2011;29:179-92 pubmed publisher
    ..FUS (FUsed in Sarcoma; also termed TLS, Translocated in LipoSarcoma)-CHOP (C/EBP HOmologous Protein; also termed DDIT3, DNA Damage-Inducible Transcript 3), a hallmark mixoid liposarcoma-associated fusion oncogene, in wild-type and ..
  27. Shao C, Lawrence M, Cobb M. Regulation of CCAAT/enhancer-binding protein homologous protein (CHOP) expression by interleukin-1 beta in pancreatic beta cells. J Biol Chem. 2010;285:19710-9 pubmed publisher
    ..kinase (MAPK) signaling pathways regulate the expression of CCAAT/enhancer-binding protein homologous protein (CHOP), which mediates endoplasmic reticulum stress-induced apoptosis...
  28. Aman P, Ron D, Mandahl N, Fioretos T, Heim S, Arheden K, et al. Rearrangement of the transcription factor gene CHOP in myxoid liposarcomas with t(12;16)(q13;p11). Genes Chromosomes Cancer. 1992;5:278-85 pubmed
    ..We have used Southern blot technique to test whether a gene of the CCAAT/enhancer binding protein (C/EBP) family, CHOP, which maps to 12q13 and is assumed to be involved in adipocyte differentiation, could be the 12q gene in question...
  29. Gachon F, Gaudray G, Thebault S, Basbous J, Koffi J, Devaux C, et al. The cAMP response element binding protein-2 (CREB-2) can interact with the C/EBP-homologous protein (CHOP). FEBS Lett. 2001;502:57-62 pubmed
    ..Here we show that CREB-2 is able to interact with C/EBP-homologous protein (CHOP), a bZIP transcription factor known to inhibit CAAT/enhancer-dependent transcription...
  30. Ramji D, Foka P. CCAAT/enhancer-binding proteins: structure, function and regulation. Biochem J. 2002;365:561-75 pubmed
    ..This review deals with the structure, biological function and the regulation of the C/EBP family. ..
  31. Newman J, Keating A. Comprehensive identification of human bZIP interactions with coiled-coil arrays. Science. 2003;300:2097-101 pubmed
    ..Biophysical studies in solution support the relative binding strengths observed with the arrays. New associations provide insights into the circadian clock and the unfolded protein response. ..
  32. Oyadomari S, Mori M. Roles of CHOP/GADD153 in endoplasmic reticulum stress. Cell Death Differ. 2004;11:381-9 pubmed
    ..pathway is C/EBP homologous protein (CHOP), also known as growth arrest- and DNA damage-inducible gene 153 (GADD153)...
  33. Göransson M, Elias E, Ståhlberg A, Olofsson A, Andersson C, Aman P. Myxoid liposarcoma FUS-DDIT3 fusion oncogene induces C/EBP beta-mediated interleukin 6 expression. Int J Cancer. 2005;115:556-60 pubmed
    The myxoid/round cell liposarcoma oncogene FUS-DDIT3 is the result of a translocation derived gene fusion between the splicing factor FUS and DDIT3...
  34. Scaiewicz V, Nahmias A, Chung R, Mueller T, Tirosh B, Shibolet O. CCAAT/enhancer-binding protein homologous (CHOP) protein promotes carcinogenesis in the DEN-induced hepatocellular carcinoma model. PLoS ONE. 2013;8:e81065 pubmed publisher
    C/EBP homologous protein (CHOP) plays pro-apoptotic roles in the integrated stress response. Recently, a tumor suppressive role for CHOP was demonstrated in lung cancer via regulation of tumor metabolism...
  35. Ohoka N, Yoshii S, Hattori T, Onozaki K, Hayashi H. TRB3, a novel ER stress-inducible gene, is induced via ATF4-CHOP pathway and is involved in cell death. EMBO J. 2005;24:1243-55 pubmed
    C/EBP homologous protein (CHOP) is a stress-inducible nuclear protein that is crucial for the development of programmed cell death and regeneration; however, the regulation of its function has not been well characterized...
  36. Pan Y, Hopkins R, Loo G. Increased GADD153 gene expression during iron chelation-induced apoptosis in Jurkat T-lymphocytes. Biochim Biophys Acta. 2004;1691:41-50 pubmed
    ..In contrast, there was mainly increased mRNA expression of Growth Arrest and DNA Damage-inducible gene 153 (GADD153), which seemed to be at the level of transcription rather than mRNA stability...
  37. Dalton L, Clarke H, Knight J, Lawson M, Wason J, Lomas D, et al. The endoplasmic reticulum stress marker CHOP predicts survival in malignant mesothelioma. Br J Cancer. 2013;108:1340-7 pubmed publisher
    ..We observed that expression of the ER stress-responsive transcription factor C/EBP homologous protein (CHOP) correlated with patient survival and remained an independent prognostic variable in pairwise comparisons with all ..
  38. Zhang Y, Qu X, Jiang L. An oasis in the desert of cancer chemotherapeutic resistance: The enlightenment from reciprocal crosstalk between signaling pathways of UPR and autophagy in cancers. Biomed Pharmacother. 2017;92:972-981 pubmed publisher
    ..as the PERK-eIF2?-ATF4 signaling pathway by ongoing research, and the transcription factor C/EBP homologous (CHOP) mediated by ATF4 were further substantiated to regulate a dozen of ATG genes transcriptionally...
  39. Zhang B, Han H, Fu S, Yang P, Gu Z, Zhou Q, et al. Dehydroeffusol inhibits gastric cancer cell growth and tumorigenicity by selectively inducing tumor-suppressive endoplasmic reticulum stress and a moderate apoptosis. Biochem Pharmacol. 2016;104:8-18 pubmed publisher
    ..stress response by promoting the overexpression of the key ER stress marker DNA damage-inducible transcript 3 (DDIT3), through upregulation of activating transcription factor 4 (ATF4)...
  40. Zheng G, Cai Z, Meng X, Zhang Y, Zhu W, Pang X, et al. Unfolded protein response mediated JNK/AP-1 signal transduction, a target for ovarian cancer treatment. Int J Clin Exp Pathol. 2015;8:6505-11 pubmed
    ..had significantly increased the expression of Endoplasmic reticulum (ER) stress regulators such as Bip, IRE1, CHOP and activation of UPR related apoptotic proteins in ovarian cancer cells...
  41. Singh R, Khatri P, Srivastava N, Jain S, Brahmachari V, Mukhopadhyay A, et al. Fluoride exposure abates pro-inflammatory response and induces in vivo apoptosis rendering zebrafish (Danio rerio) susceptible to bacterial infections. Fish Shellfish Immunol. 2017;63:314-321 pubmed publisher
    ..We conclude, chronic fluoride exposure impairs the redox balance, affects DNA repair machinery with pro-apoptotic implications and suppresses pro-inflammatory cytokines expression abrogating host immunity to bacterial infections. ..
  42. Mota M, Banini B, Cazanave S, Sanyal A. Molecular mechanisms of lipotoxicity and glucotoxicity in nonalcoholic fatty liver disease. Metabolism. 2016;65:1049-61 pubmed publisher
    ..involved in various pathways including PKR-like ER kinase (PERK), CCAAT/enhancer-binding homologous protein (CHOP), c-Jun NH2-terminal kinase-1 (JNK), Bcl-2 interacting mediator (BIM), p53 upregulated modulator of apoptosis (PUMA)..
  43. Baptista M, Tapia G, Hernández Rivas J, Martínez Trillos A, Mate J, Navarro J. MYC-rearranged lymphomas other than Burkitt: Comparison between R-CHOP and Burkitt-type immunochemotherapy. Med Clin (Barc). 2017;149:339-342 pubmed publisher
    ..to study the characteristics and outcome of a series of MYC-R lymphomas comparing the treatment results between R-CHOP based and a specific intensive regimen for BL (BURKIMAB). Retrospective study of patients diagnosed with MYC-R...
  44. Espada S, Stavik B, Holm S, Sagen E, Bjerkeli V, Skjelland M, et al. Tissue factor pathway inhibitor attenuates ER stress-induced inflammation in human M2-polarized macrophages. Biochem Biophys Res Commun. 2017;491:442-448 pubmed publisher
    ..were performed to determine the presence of the ER stress marker CCAAT/enhancer binding protein homologous protein (CHOP) and TFPI in human carotid plaque material and also in human MDMs polarized into pro-inflammatory M1 or anti-..
  45. Kusaczuk M, Krętowski R, Stypułkowska A, Cechowska Pasko M. Molecular and cellular effects of a novel hydroxamate-based HDAC inhibitor - belinostat - in glioblastoma cell lines: a preliminary report. Invest New Drugs. 2016;34:552-64 pubmed publisher
    ..In LN-229 cells this effect was followed by up-regulation of pro-apoptotic genes including Puma, Bim, Chop and p21. In treated LN-18 cells only p21 was markedly overexpressed...
  46. Yun S, Yoon Y, Lee J, Kook M, Han Y, Jung S, et al. Tauroursodeoxycholic Acid Protects against the Effects of P-Cresol-Induced Reactive Oxygen Species via the Expression of Cellular Prion Protein. Int J Mol Sci. 2018;19: pubmed publisher
    ..treatment of MSCs reduced ER stress-associated protein activation, including GRP78, PERK, eIF2?, ATF4, IRE1?, and CHOP. Next, to explore the protective mechanism adopted by TUDCA, TUDCA-mediated cellular prion protein (PrPC)..
  47. Suzuki K, Matsui Y, Higashimoto M, Kawaguchi Y, Seki S, Motomura H, et al. Myxoid liposarcoma-associated EWSR1-DDIT3 selectively represses osteoblastic and chondrocytic transcription in multipotent mesenchymal cells. PLoS ONE. 2012;7:e36682 pubmed publisher
    ..EWSR1-DDIT3 is a chimeric fusion protein generated by the myxoid liposarcoma-specific chromosomal translocation t(12;22)(q13;..
  48. Wei X, Hao X, Zhou L, Wei Q, Zhang Y, Huang W, et al. The international staging system improves the IPI risk stratification in patients with diffuse large B-cell lymphoma treated with R-CHOP. Sci Rep. 2017;7:13592 pubmed publisher
    ..II/III showed shorter overall survival (OS) and event free survival (EFS) than those with stage I treated with R-CHOP (p?=?0.012 and p?=?0.043, respectively), but not those treated with CHOP regimen (p?>?0.05)...
  49. Meenakshisundaram R, Piumelli N, Pierpaoli L, Gragnoli C. CHOP 5'UTR-c.279T>C and +nt30C>T variants are not associated with overweight condition or with tumors/cancer in Italians - a case-control study. J Exp Clin Cancer Res. 2009;28:90 pubmed publisher
    ..HNF1-beta and JAZF1 genes are associated with T2D and prostate cancer. We have previously shown that CHOP 5'UTR-c.279T>C and +nt30C>T haplotype variants contribute to T2D...
  50. Mondello P, Steiner N, Willenbacher W, Arrigo C, Cuzzocrea S, Pitini V, et al. 90Y-Ibritumomab-Tiuxetan Consolidation Therapy for Advanced-Stage Mantle Cell Lymphoma After First-Line Autologous Stem Cell Transplantation: Is It Time for a Step Forward?. Clin Lymphoma Myeloma Leuk. 2016;16:82-8 pubmed publisher
    ..affected by intermediate or high-risk MCL in complete remission (CR) or partial remission (PR) after 3 cycles of R-CHOP (rituximab, cyclophosphamide, doxorubicin [hydroxydaunorubicin], vincristine [Oncovin], prednisolone) plus 3 cycles ..
  51. Lin Y, Zhang X, Xiao W, Li B, Wang J, Jin L, et al. Endoplasmic Reticulum Stress is Involved in DFMO Attenuating Isoproterenol-Induced Cardiac Hypertrophy in Rats. Cell Physiol Biochem. 2016;38:1553-62 pubmed publisher
    ..DFMO down-regulated the expression of ODC, glucose-regulated protein 78 (GRP78), C/EBP homologous protein (CHOP), cleaved caspase-12, and Bax and up-regulated the expression of SSAT and Bcl-2...
  52. Zhang D, Gao C, Li R, Zhang L, Tian J. TEOA, a triterpenoid from Actinidia eriantha, induces autophagy in SW620 cells via endoplasmic reticulum stress and ROS-dependent mitophagy. Arch Pharm Res. 2017;40:579-591 pubmed publisher
    ..that TEOA promoted the phosphorylation of PERK and elF2?, followed by up-regulation of the downstream protein CHOP, suggesting the involvement of PERK/eIF2?/CHOP pathway and ER stress in TEOA-induced autophagy in SW620 cells...
  53. Fukuhara N. Management strategy for follicular lymphoma. Rinsho Ketsueki. 2017;58:2020-2025 pubmed publisher
    ..The optimal chemotherapy to partner with rituximab might be CHOP or bendamustine. Rituximab maintenance after successful induction rituximab-based chemotherapy prolongs PFS...
  54. Singh P, Voleti B, Agrawal A. A novel RBP-J kappa-dependent switch from C/EBP beta to C/EBP zeta at the C/EBP binding site on the C-reactive protein promoter. J Immunol. 2007;178:7302-9 pubmed
    ..Such treated nuclei contain only C/EBPzeta (also known as CHOP10 and GADD153) because the C/EBP-binding consensus oligonucleotide binds to all C/EBP family proteins except C/EBPzeta...
  55. Updegraff B, O Donnell K. Stressing the importance of CHOP in liver cancer. PLoS Genet. 2013;9:e1004045 pubmed publisher
  56. Li X, Chen L, Luo B, Li X, Wang C, Zou W, et al. Hydrogen sulfide attenuates chronic restrain stress-induced cognitive impairment by upreglulation of Sirt1 in hippocampus. Oncotarget. 2017;8:100396-100410 pubmed publisher
    ..NaHS rescued CRS-generated ER stress as evidenced by downregulations of CPR78, CHOP, and cleaved caspase-12...
  57. Liu Y, Wang X, Ding N, Mi L, Ping L, Jin X, et al. TP53 Arg72 as a favorable prognostic factor for Chinese diffuse large B-cell lymphoma patients treated with CHOP. BMC Cancer. 2017;17:743 pubmed publisher
    ..Two hundred and eighty-nine patients were treated with R-CHOP, and 136 patients received CHOP or CHOP-like as frontline regimen...
  58. Qu C, Ma J, Liu X, Xue Y, Zheng J, Liu L, et al. Dihydroartemisinin Exerts Anti-Tumor Activity by Inducing Mitochondrion and Endoplasmic Reticulum Apoptosis and Autophagic Cell Death in Human Glioblastoma Cells. Front Cell Neurosci. 2017;11:310 pubmed publisher
    ..Enhanced expression of GRP78, CHOP and eIF2? and activation of caspase 12 were additionally confirmed that endoplasmic reticulum (ER) stress pathway ..
  59. Cherasse Y, Chaveroux C, Jousse C, Maurin A, Carraro V, Parry L, et al. Role of the repressor JDP2 in the amino acid-regulated transcription of CHOP. FEBS Lett. 2008;582:1537-41 pubmed publisher
    The transcriptional activation of CHOP (C/EBP-homologous protein) by amino acid deprivation involves ATF2 and ATF4 binding at the amino acid response element within the promoter...
  60. Bai X, Liu S, Yuan L, Xie Y, Li T, Wang L, et al. Hydrogen-rich saline mediates neuroprotection through the regulation of endoplasmic reticulum stress and autophagy under hypoxia-ischemia neonatal brain injury in mice. Brain Res. 2016;1646:410-417 pubmed publisher
    ..Taken together, HS exerts neuroprotection against HIBD in neonatal mouse, mediated in part by reducing ER stress and increasing autophagy machinery. ..
  61. Rahman K, Liu Y, Kumar P, Smith T, Thorn N, Farris A, et al. C/EBP homologous protein modulates liraglutide-mediated attenuation of non-alcoholic steatohepatitis. Lab Invest. 2016;96:895-908 pubmed publisher
    The CCAAT/enhancer-binding protein (C/EBP) homologous protein (CHOP), a major transcriptional regulator of endoplasmic reticulum (ER) stress-mediated apoptosis, is implicated in lipotoxicity-induced ER stress and hepatocyte apoptosis in ..
  62. Shimodaira Y, Takahashi S, Kinouchi Y, Endo K, Shiga H, Kakuta Y, et al. Modulation of endoplasmic reticulum (ER) stress-induced autophagy by C/EBP homologous protein (CHOP) and inositol-requiring enzyme 1? (IRE1?) in human colon cancer cells. Biochem Biophys Res Commun. 2014;445:524-33 pubmed publisher
    ..In these cells, inositol-requiring enzyme1? (IRE1?) and C/EBP homologous protein (CHOP) were involved in the ER stress-autophagy pathway, and CHOP was a regulator of IRE1? protein expression...
  63. Min K, Kim H, Park E, Kwon T. Melatonin enhances thapsigargin-induced apoptosis through reactive oxygen species-mediated upregulation of CCAAT-enhancer-binding protein homologous protein in human renal cancer cells. J Pineal Res. 2012;53:99-106 pubmed publisher
    ..TG (50nm) induced approximately 10-fold expression levels of CCAAT-enhancer-binding proteins homologous protein (CHOP) compared with that of TG (50nm) alone...
  64. Liu Y, Ye Q, Liu Y, Kang J, Chen Y, Dong W. Schistosoma japonicum attenuates dextran sodium sulfate-induced colitis in mice via reduction of endoplasmic reticulum stress. World J Gastroenterol. 2017;23:5700-5712 pubmed publisher
    ..Protein and mRNA levels of IRE1?, IRE1?, GRP78, CHOP, P65, P-P65, P-I?B? and I?B? in colon tissues were examined by Western blot and RT-PCR, respectively...
  65. Baban B, Liu J, Abdelsayed R, Mozaffari M. Reciprocal relation between GADD153 and Del-1 in regulation of salivary gland inflammation in Sjögren syndrome. Exp Mol Pathol. 2013;95:288-97 pubmed publisher
    ..component of ER stress-induced apoptosis is expression of growth arrest- and DNA damage-inducible protein 153 (GADD153)...
  66. Patzelt M, Zarubova L, Klener P, Barta J, Benkova K, Brandejsova A, et al. Anaplastic Large-Cell Lymphoma Associated with Breast Implants: A Case Report of a Transgender Female. Aesthetic Plast Surg. 2018;42:451-455 pubmed publisher
    ..The patient was treated with the standard chemotherapy for systemic ALCL-6 cycles of CHOP-21. The patient was tumor-free at the 2-year follow-up...
  67. Ha T, Hansen A, Kol S, Kildegaard H, Lee G. Baicalein Reduces Oxidative Stress in CHO Cell Cultures and Improves Recombinant Antibody Productivity. Biotechnol J. 2017;: pubmed publisher
    ..Addition of baicalein significantly reduced the expression level of BiP and CHOP along with reduced reactive oxygen species level, suggesting oxidative stress accumulated in the cells can be ..
  68. Gupta S, Francis S, Nair M, Mo Y, Aggarwal B. Azadirone, a limonoid tetranortriterpene, induces death receptors and sensitizes human cancer cells to tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) through a p53 protein-independent mechanism: evidence for the role of the ROS-ERK-C. J Biol Chem. 2013;288:32343-56 pubmed publisher
    ..of ERK and through up-regulation of a transcription factor CCAAT enhancer-binding protein homologous protein (CHOP) as silencing of these signaling molecules abrogated the effect of azadirone...
  69. Suganuma M, Kurusu M, Suzuki K, Tasaki E, Fujiki H. Green tea polyphenol stimulates cancer preventive effects of celecoxib in human lung cancer cells by upregulation of GADD153 gene. Int J Cancer. 2006;119:33-40 pubmed
    ..apoptosis and expression of apoptosis related genes, with emphasis on growth arrest and DNA damage-inducible 153 (GADD153) gene, in human lung cancer cell line PC-9: Cotreatment with EGCG plus celecoxib strongly induced the expression ..