COMT

Summary

Gene Symbol: COMT
Description: catechol-O-methyltransferase
Alias: HEL-S-98n, catechol O-methyltransferase, catechol-O-methyltransferase isoform, epididymis secretory sperm binding protein Li 98n, testicular tissue protein Li 42
Species: human
Products:     COMT

Top Publications

  1. Roffman J, Gollub R, Calhoun V, Wassink T, Weiss A, Ho B, et al. MTHFR 677C --> T genotype disrupts prefrontal function in schizophrenia through an interaction with COMT 158Val --> Met. Proc Natl Acad Sci U S A. 2008;105:17573-8 pubmed publisher
    ..The catechol-O-methyltransferase (COMT) 158Val --> Met polymorphism (rs4680), which affects the availability of prefrontal dopamine signaling, ..
  2. Portnova G, Sysoeva O, Maliuchenko N, Timofeeva M, Kulikova M, Tonevitskii A, et al. [Genetic basis of time perception in athletes]. Zh Vyssh Nerv Deiat Im I P Pavlova. 2007;57:450-60 pubmed
    ..b>COMT gene, responsible for dopamine destruction, influences on reproduction of short time intervals (1-2 s)...
  3. Nedic G, Nikolac M, Sviglin K, Muck Seler D, Borovecki F, Pivac N. Association study of a functional catechol-O-methyltransferase (COMT) Val108/158Met polymorphism and suicide attempts in patients with alcohol dependence. Int J Neuropsychopharmacol. 2011;14:377-88 pubmed publisher
    ..The enzyme catechol-O-methyl transferase (COMT) degrades dopamine, epinephrine and norepinephrine...
  4. Amstadter A, Nugent N, Koenen K, Ruggiero K, Acierno R, Galea S, et al. Association between COMT, PTSD, and increased smoking following hurricane exposure in an epidemiologic sample. Psychiatry. 2009;72:360-9 pubmed publisher
    ..and persistence of cigarette smoking is moderately heritable; two recent investigations have implicated the COMT Val158Met (also known as rs4680) polymorphism in smoking age of initiation, dependence, as well as in quantity and ..
  5. Perroud N, Jaussent I, Guillaume S, Bellivier F, Baud P, Jollant F, et al. COMT but not serotonin-related genes modulates the influence of childhood abuse on anger traits. Genes Brain Behav. 2010;9:193-202 pubmed publisher
    ..The functional polymorphism of the catecholamine-O-methyl-transferase (COMT) gene Val158Met significantly modulated the association between sexual abuse and anger-trait level (P = 0.001)...
  6. Marenco S, Savostyanova A, van der Veen J, Geramita M, Stern A, Barnett A, et al. Genetic modulation of GABA levels in the anterior cingulate cortex by GAD1 and COMT. Neuropsychopharmacology. 2010;35:1708-17 pubmed publisher
    ..of living subjects: glutamic acid decarboxylase 1 (GAD1), which encodes GAD67, and catechol-o-methyltransferase (COMT), which regulates synaptic dopamine in the cortex...
  7. Barnett J, Heron J, Goldman D, Jones P, Xu K. Effects of catechol-O-methyltransferase on normal variation in the cognitive function of children. Am J Psychiatry. 2009;166:909-16 pubmed publisher
    ..A functional valine-to-methionine (Val(158)Met) polymorphism in the catechol-O-methyltransferase (COMT) gene has been associated with cognitive function and brain metabolic activity accompanying such tasks...
  8. Raznahan A, Greenstein D, Lee Y, Long R, Clasen L, Gochman P, et al. Catechol-o-methyl transferase (COMT) val158met polymorphism and adolescent cortical development in patients with childhood-onset schizophrenia, their non-psychotic siblings, and healthy controls. Neuroimage. 2011;57:1517-23 pubmed publisher
    ..issues by relating a functional Val→Met polymorphism within the gene encoding catechol-o-methyltransferase (COMT)-a key enzymatic regulator of cortical dopamine levels-to longitudinal structural neuroimaging measures of cortical ..
  9. Gennatas E, Cholfin J, Zhou J, Crawford R, Sasaki D, Karydas A, et al. COMT Val158Met genotype influences neurodegeneration within dopamine-innervated brain structures. Neurology. 2012;78:1663-9 pubmed publisher
    We sought to determine whether the Val(158)Met polymorphism in the catechol-O-methyltransferase (COMT) gene influences neurodegeneration within dopamine-innervated brain regions...

More Information

Publications128 found, 100 shown here

  1. Honea R, Verchinski B, Pezawas L, Kolachana B, Callicott J, Mattay V, et al. Impact of interacting functional variants in COMT on regional gray matter volume in human brain. Neuroimage. 2009;45:44-51 pubmed publisher
    Functional variants in the catechol-O-methyltransferase (COMT) gene have been shown to impact cognitive function, cortical physiology and risk for schizophrenia...
  2. Nedic G, Nikolac M, Borovecki F, Hajnsek S, Muck Seler D, Pivac N. Association study of a functional catechol-O-methyltransferase polymorphism and smoking in healthy Caucasian subjects. Neurosci Lett. 2010;473:216-9 pubmed publisher
    ..The association of a functional common polymorphism in the catechol-o-methyltransferase gene (COMT Val158Met) with smoking behavior has been extensively studied, but with divergent findings...
  3. Rowe J, Hughes L, Williams Gray C, Bishop S, Fallon S, Barker R, et al. The val158met COMT polymorphism's effect on atrophy in healthy aging and Parkinson's disease. Neurobiol Aging. 2010;31:1064-8 pubmed publisher
    ..There were no global or local interactions between Parkinson's disease and COMT val(158)met genotype on morphometry...
  4. Moreno Galván M, Herrera González N, Robles Pérez V, Velasco Rodríguez J, Tapia Conyer R, Sarti E. Impact of CYP1A1 and COMT genotypes on breast cancer risk in Mexican women: a pilot study. Int J Biol Markers. 2010;25:157-63 pubmed
    ..Data suggest that estrogen-metabolizing genes may be involved in breast cancer carcinogenesis...
  5. Loggia M, Jensen K, Gollub R, Wasan A, Edwards R, Kong J. The catechol-O-methyltransferase (COMT) val158met polymorphism affects brain responses to repeated painful stimuli. PLoS ONE. 2011;6:e27764 pubmed publisher
    ..Perhaps the prime example of this inconsistency is represented by catechol-O-methyltransferase (COMT), as its substantial association to pain sensitivity has been reported in various studies, but rejected in several ..
  6. Qin X, Peng Q, Qin A, Chen Z, Lin L, Deng Y, et al. Association of COMT Val158Met polymorphism and breast cancer risk: an updated meta-analysis. Diagn Pathol. 2012;7:136 pubmed publisher
    Catechol-O-methyltransferase (COMT) is one of the most important enzymes involved in estrogen metabolism and its functional genetic polymorphisms may be associated with breast cancer (BC) risk...
  7. Hall K, Nelson C, Davis R, Buring J, Kirsch I, Mittleman M, et al. Polymorphisms in catechol-O-methyltransferase modify treatment effects of aspirin on risk of cardiovascular disease. Arterioscler Thromb Vasc Biol. 2014;34:2160-7 pubmed publisher
    Catechol-O-methyltransferase (COMT), a key enzyme in catecholamine metabolism, is implicated in cardiovascular, sympathetic, and endocrine pathways...
  8. Hall K, Lembo A, Kirsch I, Ziogas D, Douaiher J, Jensen K, et al. Catechol-O-methyltransferase val158met polymorphism predicts placebo effect in irritable bowel syndrome. PLoS ONE. 2012;7:e48135 pubmed publisher
    ..Catechol-O-methyltransferase (COMT), an important enzyme in dopamine catabolism plays a key role in processes associated with the placebo effect such ..
  9. Hatzimanolis A, Vitoratou S, Mandelli L, Vaiopoulos C, Nearchou F, Stefanis C, et al. Potential role of membrane-bound COMT gene polymorphisms in female depression vulnerability. J Affect Disord. 2013;148:316-22 pubmed publisher
    Several polymorphic variants within the catechol-O-methyltransferase (COMT) gene locus have been associated with a number of diverse psychiatric phenotypes including affective disorders...
  10. Soeiro de Souza M, Stanford M, Bio D, Machado Vieira R, Moreno R. Association of the COMT Met¹?? allele with trait impulsivity in healthy young adults. Mol Med Rep. 2013;7:1067-72 pubmed publisher
    ..Catechol-O-methyltransferase (COMT) is a key enzyme in the catabolism of DA within the prefrontal cortex (PFC) and has been suggested to play a role ..
  11. Kang J, Kim S, Song Y, Namkoong K, An S. Genetic influence of COMT and BDNF gene polymorphisms on resilience in healthy college students. Neuropsychobiology. 2013;68:174-80 pubmed publisher
    ..We investigated the genetic influence of the catechol-O-methyltransferase (COMT) Val158Met and the brain-derived neurotrophic factor (BDNF) Val66Met for individual differences in resilience in ..
  12. Landau R, Liu S, Blouin J, Carvalho B. The effect of OPRM1 and COMT genotypes on the analgesic response to intravenous fentanyl labor analgesia. Anesth Analg. 2013;116:386-91 pubmed publisher
    ..472G/A, p.158Val/Met) of the catechol-O-methyltransferase (COMT) gene in women requesting labor analgesia. Labor analgesia was initiated with IV fentanyl 1.5 ?g/kg...
  13. Kontis D, Theochari E, Fryssira H, Kleisas S, Sofocleous C, Andreopoulou A, et al. COMT and MTHFR polymorphisms interaction on cognition in schizophrenia: an exploratory study. Neurosci Lett. 2013;537:17-22 pubmed publisher
    The investigation of the catechol-O-methyltransferase (COMT-[rs4680]) and methylenetetrahydrofolate reductase (MTHFR-[rs1801133]) polymorphisms' interaction might shed light into the pathogenetic mechanisms of the cognitive dysfunction in ..
  14. Alemany S, Arias B, Fatjó Vilas M, Villa H, Moya J, Ibáñez M, et al. Psychosis-inducing effects of cannabis are related to both childhood abuse and COMT genotypes. Acta Psychiatr Scand. 2014;129:54-62 pubmed publisher
    To test whether the association between childhood abuse, cannabis use and psychotic experiences (PEs) was moderated by the COMT (catechol-O-methyltransferase) gene.
  15. Belfer I, Segall S, Lariviere W, Smith S, Dai F, Slade G, et al. Pain modality- and sex-specific effects of COMT genetic functional variants. Pain. 2013;154:1368-76 pubmed publisher
    The enzyme catechol-O-methyltransferase (COMT) metabolizes catecholamine neurotransmitters involved in a number of physiological functions, including pain perception...
  16. Mitaki S, Isomura M, Maniwa K, Yamasaki M, Nagai A, Nabika T, et al. Apathy is associated with a single-nucleotide polymorphism in a dopamine-related gene. Neurosci Lett. 2013;549:87-91 pubmed publisher
    ..A significant association was found between an SNP in the catechol-O-methyltransferase (COMT) gene (rs4680) encoding the low-activity Met allele and apathy...
  17. Xiao L, Tong M, Jin Y, Huang W, Li Z. The l58Val/Met polymorphism of catechol-O-methyl transferase gene and prostate cancer risk: a meta-analysis. Mol Biol Rep. 2013;40:1835-41 pubmed publisher
    The association between COMT Val158Met polymorphism and prostate cancer has been evaluated. However, the results of these studies on the association remain conflicting...
  18. Verdejo Garcia A, Fagundo A, Cuenca A, Rodríguez J, Cuyàs E, Langohr K, et al. COMT val158met and 5-HTTLPR genetic polymorphisms moderate executive control in cannabis users. Neuropsychopharmacology. 2013;38:1598-606 pubmed publisher
    ..of ?9-tetrahydrocannabinol (THC) exposure and to executive functions in animals: the catechol-O-methyltransferase (COMT) gene val158met polymorphism and the SLC6A4 gene 5-HTTLPR polymorphism...
  19. Goldberg X, Fatjó Vilas M, Alemany S, Nenadic I, Gasto C, Fañanás L. Gene-environment interaction on cognition: a twin study of childhood maltreatment and COMT variability. J Psychiatr Res. 2013;47:989-94 pubmed publisher
    The functional variant Val(158)Met in the coding sequence of COMT gene is involved in the modulation of dopamine availability in the prefrontal cortex in both clinical and general population samples...
  20. Vinkers C, van Gastel W, Schubart C, van Eijk K, Luykx J, van Winkel R, et al. The effect of childhood maltreatment and cannabis use on adult psychotic symptoms is modified by the COMT Val¹??Met polymorphism. Schizophr Res. 2013;150:303-11 pubmed publisher
    ..In this context, an extensively studied psychosis vulnerability gene is catechol-methyl-transferase (COMT)...
  21. Wendt L, Albring A, Benson S, Engler H, Engler A, Hinney A, et al. Catechol-O-methyltransferase Val158Met polymorphism is associated with somatosensory amplification and nocebo responses. PLoS ONE. 2014;9:e107665 pubmed publisher
    ..We focused on the genetic polymorphisms in the catechol-O-methyltransferase (COMT) gene (Val158Met) and analyzed drug specific and general side effects before and after immunosuppressive medication ..
  22. Ahlers S, Elens L, van Gulik L, van Schaik R, van Dongen E, Bruins P, et al. The Val158Met polymorphism of the COMT gene is associated with increased pain sensitivity in morphine-treated patients undergoing a painful procedure after cardiac surgery. Br J Clin Pharmacol. 2013;75:1506-15 pubmed publisher
    The catechol-O-methyltransferase (COMT) Val158Met polymorphism affected pain sensitivity of healthy volunteers upon application of experimental pain stimuli...
  23. Tunbridge E, Farrell S, Harrison P, Mackay C. Catechol-O-methyltransferase (COMT) influences the connectivity of the prefrontal cortex at rest. Neuroimage. 2013;68:49-54 pubmed publisher
    Catechol-O-methyltransferase (COMT) modulates dopamine in the prefrontal cortex (PFC) and influences PFC dopamine-dependent cognitive task performance...
  24. Wardle M, de Wit H, Penton Voak I, Lewis G, Munafò M. Lack of association between COMT and working memory in a population-based cohort of healthy young adults. Neuropsychopharmacology. 2013;38:1253-63 pubmed publisher
    The Val158Met polymorphism of the catechol-O-methyltransferase (COMT) gene is an important regulator of dopamine in the prefrontal cortex, an area critical to working memory...
  25. Malloy Diniz L, Lage G, Campos S, de Paula J, de Souza Costa D, Romano Silva M, et al. Association between the Catechol O-methyltransferase (COMT) Val158met polymorphism and different dimensions of impulsivity. PLoS ONE. 2013;8:e73509 pubmed publisher
    ..by a substitution of valine (val) with methionine (met) in the 158 codon of the Catechol-o-Methyltransferase gene (COMT-val158met)...
  26. Haase Fielitz A, Haase M, Bellomo R, Lambert G, Matalanis G, Story D, et al. Decreased catecholamine degradation associates with shock and kidney injury after cardiac surgery. J Am Soc Nephrol. 2009;20:1393-403 pubmed publisher
    Enzymatic pathways involving catechol-O-methyltransferase (COMT) catabolize circulating catecholamines...
  27. Hamajima N, Matsuo K, Tajima K, Mizutani M, Iwata H, Iwase T, et al. Limited association between a catechol-O-methyltransferase (COMT) polymorphism and breast cancer risk in Japan. Int J Clin Oncol. 2001;6:13-8 pubmed
    Catechol-O-methyltransferase (COMT) inactivates the estradiol metabolites, 2-hydroxy estradiol and 4-hydroxy estradiol...
  28. Rakvåg T, Ross J, Sato H, Skorpen F, Kaasa S, Klepstad P. Genetic variation in the catechol-O-methyltransferase (COMT) gene and morphine requirements in cancer patients with pain. Mol Pain. 2008;4:64 pubmed publisher
    ..are involved in the modulation of pain and are partly metabolized by the catechol-O-methyltransferase (COMT) enzyme...
  29. Ding H, Fu Y, Chen W, Wang Z. COMT Val158Met polymorphism and breast cancer risk: evidence from 26 case-control studies. Breast Cancer Res Treat. 2010;123:265-70 pubmed publisher
    The Catechol-O-methyltransferase (COMT) plays an important role in the development of breast cancer. Many previous epidemiologic studies explored the association of COMT Val158Met polymorphism with breast cancer susceptibility...
  30. Liou Y, Tsai S, Hong C, Wang Y, Lai I. Association analysis of a functional catechol-o-methyltransferase gene polymorphism in schizophrenic patients in Taiwan. Neuropsychobiology. 2001;43:11-4 pubmed
    The catechol-O-methyltransferase (COMT) gene was thought to be a candidate gene for schizophrenia because of its role in inactivating dopamine...
  31. Sasaki M, Kaneuchi M, Sakuragi N, Dahiya R. Multiple promoters of catechol-O-methyltransferase gene are selectively inactivated by CpG hypermethylation in endometrial cancer. Cancer Res. 2003;63:3101-6 pubmed
    Catechol-O-methyltransferase (COMT) plays an important role in estrogen-induced cancers because COMT inactivates catechol estrogens that have cancer-promoting activities...
  32. Freitag C, Domschke K, Rothe C, Lee Y, Hohoff C, Gutknecht L, et al. Interaction of serotonergic and noradrenergic gene variants in panic disorder. Psychiatr Genet. 2006;16:59-65 pubmed
    ..As the sample size was small and no adjustment for multiple testing was made, the assessment of the interacting risk alleles needs replication in a larger sample with higher power. ..
  33. Camara E, Krämer U, Cunillera T, Marco Pallares J, Cucurell D, Nager W, et al. The effects of COMT (Val108/158Met) and DRD4 (SNP -521) dopamine genotypes on brain activations related to valence and magnitude of rewards. Cereb Cortex. 2010;20:1985-96 pubmed publisher
    ..volunteers being homozygous for either the Valine or Methionine variant of the catechol-O-methyltransferase (COMT) codon 158 polymorphism as well as homozygous for the C or T variant of the SNP -521 polymorphism of the dopamine ..
  34. Bishop S, Cohen J, Fossella J, Casey B, Farah M. COMT genotype influences prefrontal response to emotional distraction. Cogn Affect Behav Neurosci. 2006;6:62-70 pubmed
    ..primarily either the influence of polymorphisms in dopaminergic genes, especially the catechol-O-methyltransferase (COMT) gene, on prefrontal cognitive processes such as working memory, or that of polymorphisms in the serotonin ..
  35. Caspi A, Langley K, Milne B, Moffitt T, O DONOVAN M, Owen M, et al. A replicated molecular genetic basis for subtyping antisocial behavior in children with attention-deficit/hyperactivity disorder. Arch Gen Psychiatry. 2008;65:203-10 pubmed publisher
    ..To test if variations in the catechol O-methyltransferase gene (COMT) would prove useful in identifying the subset of children with ADHD who exhibit antisocial behavior...
  36. Bearden C, Jawad A, Lynch D, Sokol S, Kanes S, McDonald McGinn D, et al. Effects of a functional COMT polymorphism on prefrontal cognitive function in patients with 22q11.2 deletion syndrome. Am J Psychiatry. 2004;161:1700-2 pubmed
    ..2 deletion syndrome could result from haploinsufficiency of the catechol O-methyltransferase (COMT) gene, located within the 22q11 region...
  37. Bruder G, Keilp J, Xu H, Shikhman M, Schori E, Gorman J, et al. Catechol-O-methyltransferase (COMT) genotypes and working memory: associations with differing cognitive operations. Biol Psychiatry. 2005;58:901-7 pubmed
    Catechol-O-methyltransferase (COMT) is a strong candidate gene for schizophrenia and cognitive functions disrupted in this disorder...
  38. Hevir N, Sinkovec J, Rizner T. Disturbed expression of phase I and phase II estrogen-metabolizing enzymes in endometrial cancer: lower levels of CYP1B1 and increased expression of S-COMT. Mol Cell Endocrinol. 2011;331:158-67 pubmed publisher
    ..I and phase II estrogen-metabolizing enzymes: CYP1A1, CYP1A2, CYP1B1, CYP3A5, CYP3A7, SULT1A1, SULT1E1, SULT2B1, COMT, UGT2B7, and GSTP1 were studied by real-time PCR in 38 samples of cancerous and adjacent control endometrium...
  39. Lachman H, Papolos D, Saito T, Yu Y, Szumlanski C, Weinshilboum R. Human catechol-O-methyltransferase pharmacogenetics: description of a functional polymorphism and its potential application to neuropsychiatric disorders. Pharmacogenetics. 1996;6:243-50 pubmed
    Catechol-O-methyltransferase (COMT) inactivates catecholamines and catechol drugs such as L-DOPA...
  40. Le Marchand L, Donlon T, Kolonel L, Henderson B, Wilkens L. Estrogen metabolism-related genes and breast cancer risk: the multiethnic cohort study. Cancer Epidemiol Biomarkers Prev. 2005;14:1998-2003 pubmed
    ..in several genes in the estradiol/estrone metabolism pathway (CYP1A1*2A, CYP1A2*1F, CYP1B1 Leu432Val, CYP3A4*1B, COMT Val158Met, SULT1A1Arg213His) as well as the Arg554Lys variant in AHR (a transcription factor for CYP1A1, CYP1A2, ..
  41. Harris S, Wright A, Hayward C, Starr J, Whalley L, Deary I. The functional COMT polymorphism, Val 158 Met, is associated with logical memory and the personality trait intellect/imagination in a cohort of healthy 79 year olds. Neurosci Lett. 2005;385:1-6 pubmed
    A polymorphism (Val 158 Met) in the gene for catechol-O-methyl transferase (COMT) was previously associated with differences in cognitive ability and personality...
  42. Pooley E, Fineberg N, Harrison P. The met(158) allele of catechol-O-methyltransferase (COMT) is associated with obsessive-compulsive disorder in men: case-control study and meta-analysis. Mol Psychiatry. 2007;12:556-61 pubmed
    Existing data suggest a genetic association between the met(158) allele of catechol-O-methyltransferase (COMT) and obsessive-compulsive disorder (OCD). However, the results are inconclusive and complicated by possible gender differences...
  43. Borroni B, Grassi M, Costanzi C, Zanetti M, Archetti S, Franzoni S, et al. Haplotypes in cathechol-O-methyltransferase gene confer increased risk for psychosis in Alzheimer disease. Neurobiol Aging. 2007;28:1231-8 pubmed
    The gene encoding catechol-O-methyltransferase (COMT) has been suggested as a candidate for Alzheimer-related psychosis (AD-P) susceptibility, and an association between AD-P and a functional valine to methionine polymorphism has been ..
  44. Vossen H, Kenis G, Rutten B, Van Os J, Hermens H, Lousberg R. The genetic influence on the cortical processing of experimental pain and the moderating effect of pain status. PLoS ONE. 2010;5:e13641 pubmed publisher
    Research suggests that the COMT Val(158)Met, BDNF Val(66)Met and OPRM1 A(118)G polymorphisms moderate the experience of pain...
  45. Nolan K, Bilder R, Lachman H, Volavka J. Catechol O-methyltransferase Val158Met polymorphism in schizophrenia: differential effects of Val and Met alleles on cognitive stability and flexibility. Am J Psychiatry. 2004;161:359-61 pubmed
    The catechol O-methyltransferase (COMT) Val158Met polymorphism has been associated with cognitive and behavioral phenotypes in schizophrenia. Whether COMT genotype is beneficial may depend on phenotype definition...
  46. Williams L, Gatt J, Grieve S, Dobson Stone C, Paul R, Gordon E, et al. COMT Val(108/158)Met polymorphism effects on emotional brain function and negativity bias. Neuroimage. 2010;53:918-25 pubmed publisher
    ..Here, we examined the impact of the catechol-O-methyltransferase (COMT) Val(108/158)Met polymorphism, involved in dopamine and norepinephrine catabolism, on both emotional brain function ..
  47. Egan M, Goldberg T, Kolachana B, Callicott J, Mazzanti C, Straub R, et al. Effect of COMT Val108/158 Met genotype on frontal lobe function and risk for schizophrenia. Proc Natl Acad Sci U S A. 2001;98:6917-22 pubmed
    ..the relationship of a common functional polymorphism (Val(108/158) Met) in the catechol-O-methyltransferase (COMT) gene, which accounts for a 4-fold variation in enzyme activity and dopamine catabolism, with both prefrontally ..
  48. van Amelsvoort T, Zinkstok J, Figee M, Daly E, Morris R, Owen M, et al. Effects of a functional COMT polymorphism on brain anatomy and cognitive function in adults with velo-cardio-facial syndrome. Psychol Med. 2008;38:89-100 pubmed
    ..One gene on 22q11 is catechol-O-methyltransferase (COMT): an enzyme that degrades dopamine and contains a functional polymorphism (Val158Met) affecting enzyme activity...
  49. Liu B, Song M, Li J, Liu Y, Li K, Yu C, et al. Prefrontal-related functional connectivities within the default network are modulated by COMT val158met in healthy young adults. J Neurosci. 2010;30:64-9 pubmed publisher
    ..and imaging genetic paradigms, we investigated whether individual default network connectivity was modulated by COMT val(158)met in 57 healthy young subjects...
  50. Walder D, Trotman H, Cubells J, Brasfield J, Tang Y, Walker E. Catechol-O-methyltransferase modulation of cortisol secretion in psychiatrically at-risk and healthy adolescents. Psychiatr Genet. 2010;20:166-70 pubmed publisher
    Recent research implicates the catechol-O-methyltransferase (COMT) ValMet polymorphism in stress sensitivity, through modulation of hypothalamic-pituitary-adrenal (HPA) function...
  51. Mao C, Wang X, Qiu L, Liao R, Ding H, Chen Q. Lack of association between catechol-O-methyltransferase Val108/158Met polymorphism and breast cancer risk: a meta-analysis of 25,627 cases and 34,222 controls. Breast Cancer Res Treat. 2010;121:719-25 pubmed publisher
    Epidemiological studies have evaluated the association between catechol-O-methyltransferase (COMT) Val108/158Met polymorphism and breast cancer risk. However, the results remain conflicting rather than conclusive...
  52. Pelayo Teran J, Perez Iglesias R, Mata I, Carrasco Marin E, Vazquez Barquero J, Crespo Facorro B. Catechol-O-Methyltransferase (COMT) Val158Met variations and cannabis use in first-episode non-affective psychosis: clinical-onset implications. Psychiatry Res. 2010;179:291-6 pubmed publisher
    ..The Val158Met polymorphism of the COMT (Catechol-O-Methyltransferase) gene, involved in dopamine regulation and related to negative symptoms, has been ..
  53. Voisey J, Swagell C, Hughes I, Lawford B, Young R, Morris C. HapMap tag-SNP analysis confirms a role for COMT in schizophrenia risk and reveals a novel association. Eur Psychiatry. 2012;27:372-6 pubmed publisher
    Catechol-O-methyl transferase (COMT) encodes an enzyme involved in the metabolism of dopamine and maps to a commonly deleted region that increases schizophrenia risk...
  54. Chen J, Song J, Yuan P, Tian Q, Ji Y, Ren Patterson R, et al. Orientation and cellular distribution of membrane-bound catechol-O-methyltransferase in cortical neurons: implications for drug development. J Biol Chem. 2011;286:34752-60 pubmed publisher
    Catechol-O-methyltransferase (COMT) is a key enzyme for inactivation and metabolism of catechols, including dopamine, norepinephrine, caffeine, and estrogens...
  55. Rakvåg T, Klepstad P, Baar C, Kvam T, Dale O, Kaasa S, et al. The Val158Met polymorphism of the human catechol-O-methyltransferase (COMT) gene may influence morphine requirements in cancer pain patients. Pain. 2005;116:73-8 pubmed
    Catechol-O-methyltransferase (COMT) inactivates dopamine, epinephrine and norepinephrine in the nervous system...
  56. Mata I, Perez Iglesias R, Pelayo Teran J, Rodríguez Sánchez J, Gonzalez Blanch C, Carrasco Marin E, et al. Lack of influence of COMT Val158Met genotype on cognition in first-episode non-affective psychosis. Schizophr Res. 2008;102:206-9 pubmed publisher
    b>COMT gene is a logical candidate gene for schizophrenia...
  57. Montag C, Buckholtz J, Hartmann P, Merz M, Burk C, Hennig J, et al. COMT genetic variation affects fear processing: psychophysiological evidence. Behav Neurosci. 2008;122:901-9 pubmed publisher
    ..A coding variant in one such gene, encoding the dopamine catabolic enzyme catechol-O-methyltransferase (COMT Val158Met), has previously been associated with anxiety and with anxiety-related temperament and altered neural ..
  58. Benedetti F, Barbini B, Bernasconi A, Fulgosi M, Dallaspezia S, Gavinelli C, et al. Acute antidepressant response to sleep deprivation combined with light therapy is influenced by the catechol-O-methyltransferase Val(108/158)Met polymorphism. J Affect Disord. 2010;121:68-72 pubmed publisher
    Catechol-O-methyltransferase (COMT) inactivates norepinephrine and dopamine via methyl conjugation, and a G-A transition in the COMT gene (rs4680) influences the enzyme activity...
  59. Gu Z, Feng X, Dong X, Chan P. Smoking, genes encoding dopamine pathway and risk for Parkinson's disease. Neurosci Lett. 2010;482:31-4 pubmed publisher
    ..Genotypes were determined for SLC6A3 VNTR, COMT Val108/158Met and MAO-B intron13 A/G polymorphisms by PCR-RFLP, DHPLC and sequencing...
  60. Störmer V, Passow S, Biesenack J, Li S. Dopaminergic and cholinergic modulations of visual-spatial attention and working memory: insights from molecular genetic research and implications for adult cognitive development. Dev Psychol. 2012;48:875-89 pubmed publisher
    ..We report novel data showing an effect of dopamine COMT gene on spatial updating processes in older but not in younger adults, indicating potential magnification of ..
  61. Lim W, Chen Y, Chuah K, Eng P, Leong S, Lim E, et al. Female reproductive factors, gene polymorphisms in the estrogen metabolism pathway, and risk of lung cancer in Chinese women. Am J Epidemiol. 2012;175:492-503 pubmed publisher
    ..and 5 estrogen pathway gene polymorphisms (CYP17 rs743572, CYP19A1 rs10046, ER? rs1256049, ER? rs4986938, and COMT rs4680) among 702 Singapore Chinese female lung cancer cases and 1,578 hospital controls, of whom 433 cases (61...
  62. Wu R, Cheng C, Chen K, Lu S, Shan D, Ho Y, et al. The COMT L allele modifies the association between MAOB polymorphism and PD in Taiwanese. Neurology. 2001;56:375-82 pubmed
    Reports suggest that catechol-O-methyltransferase (COMT(L/L)) (Val(158)/Met) and monoamine oxidase B (MAOB) intron 13 genotype polymorphism is associated with PD...
  63. Joober R, Gauthier J, Lal S, Bloom D, Lalonde P, Rouleau G, et al. Catechol-O-methyltransferase Val-108/158-Met gene variants associated with performance on the Wisconsin Card Sorting Test. Arch Gen Psychiatry. 2002;59:662-3 pubmed
  64. McGrath M, Kawachi I, Ascherio A, Colditz G, Hunter D, De Vivo I. Association between catechol-O-methyltransferase and phobic anxiety. Am J Psychiatry. 2004;161:1703-5 pubmed
    The authors assessed the association between the catechol-O-methyltransferase (COMT) Val158Met polymorphism and scores on the phobic anxiety scale of the Crown-Crisp Experimental Index...
  65. Wray N, James M, Dumenil T, Handoko H, Lind P, Montgomery G, et al. Association study of candidate variants of COMT with neuroticism, anxiety and depression. Am J Med Genet B Neuropsychiatr Genet. 2008;147B:1314-8 pubmed publisher
    The Val158Met polymorphism of the gene encoding catechol-O-methyltransferase (COMT) is one of the most widely tested variants for association with psychiatric disorders, but replication has been inconsistent including both sex limitation ..
  66. Yamano E, Isowa T, Nakano Y, Matsuda F, Hashimoto Tamaoki T, Ohira H, et al. Association study between reward dependence temperament and a polymorphism in the phenylethanolamine N-methyltransferase gene in a Japanese female population. Compr Psychiatry. 2008;49:503-7 pubmed publisher
    ..with the Temperament and Character Inventory, and 5 polymorphisms in genes of norepinephrine pathways, ADRB1, COMT, PNMT, SLC18A1, and SLC6A2, in 85 Japanese female nursing students...
  67. McLean S, Diatchenko L, Lee Y, Swor R, Domeier R, Jones J, et al. Catechol O-methyltransferase haplotype predicts immediate musculoskeletal neck pain and psychological symptoms after motor vehicle collision. J Pain. 2011;12:101-7 pubmed publisher
    Genetic variations in the catechol-O-methyltransferase (COMT) gene have been associated with experimental pain and risk of chronic pain development, but no studies have examined genetic predictors of neck pain intensity and other patient ..
  68. Azzam A, Mathews C. Meta-analysis of the association between the catecholamine-O-methyl-transferase gene and obsessive-compulsive disorder. Am J Med Genet B Neuropsychiatr Genet. 2003;123B:64-9 pubmed
    ..The dopaminergic system has been implicated in the pathogenesis of OCD, and catecholamine-O-methyl-transferase (COMT) is a key modulator of dopaminergic and noradrenergic neurotransmission...
  69. Bellgrove M, Domschke K, Hawi Z, Kirley A, Mullins C, Robertson I, et al. The methionine allele of the COMT polymorphism impairs prefrontal cognition in children and adolescents with ADHD. Exp Brain Res. 2005;163:352-60 pubmed
    ..A functional polymorphism (Val158Met) of the catechol-O-methyltransferase (COMT) gene has attracted interest as a candidate gene for ADHD...
  70. Sweet R, Devlin B, Pollock B, Sukonick D, Kastango K, Bacanu S, et al. Catechol-O-methyltransferase haplotypes are associated with psychosis in Alzheimer disease. Mol Psychiatry. 2005;10:1026-36 pubmed
    ..of a three-locus haplotype, including a G-->A transition at codon 108/158 of catechol-O-methyltransferase (COMT) resulting in a Val-->Met substitution, has been reported to confer an increased risk for schizophrenia...
  71. Modugno F, Zmuda J, Potter D, Cai C, Ziv E, Cummings S, et al. Estrogen metabolizing polymorphisms and breast cancer risk among older white women. Breast Cancer Res Treat. 2005;93:261-70 pubmed
    ..white women from the Study of Osteoporotic Fractures (SOF) were genotyped for the catechol-O-methyltransferase (COMT) Val108Met polymorphism and the CYP1A1*2C locus...
  72. Woodward N, Jayathilake K, Meltzer H. COMT val108/158met genotype, cognitive function, and cognitive improvement with clozapine in schizophrenia. Schizophr Res. 2007;90:86-96 pubmed
    ..nucleotide polymorphism (SNP), the val108/158met SNP, within the gene that codes for catechol-O-methyltransferase (COMT), a key enzyme involved in regulating dopamine (DA) transmission within the prefrontal cortex (PFC), is related to ..
  73. Domschke K, Ohrmann P, Braun M, Suslow T, Bauer J, Hohoff C, et al. Influence of the catechol-O-methyltransferase val158met genotype on amygdala and prefrontal cortex emotional processing in panic disorder. Psychiatry Res. 2008;163:13-20 pubmed publisher
    ..The functional val158met polymorphism in the catechol-O-methyltransferase (COMT) gene has been found to be associated with panic disorder and to influence limbic and prefrontal brain activation ..
  74. Holtzer R, Ozelius L, Xue X, Wang T, Lipton R, Verghese J. Differential effects of COMT on gait and executive control in aging. Neurobiol Aging. 2010;31:523-31 pubmed publisher
    ..Because polymorphisms in catechol-O-methyltransferase (COMT) influence these cognitive processes we hypothesized that the same polymorphisms may influence gait velocity...
  75. Benedetti F, Dallaspezia S, Colombo C, Lorenzi C, Pirovano A, Smeraldi E. Effect of catechol-O-methyltransferase Val(108/158)Met polymorphism on antidepressant efficacy of fluvoxamine. Eur Psychiatry. 2010;25:476-8 pubmed publisher
    The catechol-O-methyltransferase (COMT) enzyme inactivates catecholamines, and the COMT Val(108/158)Met polymorphism (rs4680) influences the enzyme activity...
  76. Kolesnikov Y, Gabovits B, Levin A, Voiko E, Veske A. Combined catechol-O-methyltransferase and mu-opioid receptor gene polymorphisms affect morphine postoperative analgesia and central side effects. Anesth Analg. 2011;112:448-53 pubmed publisher
    ..More studies are needed to characterize the combined effects of multiple genes and demographic as well as clinical variables in predicting the correct morphine dosage and corresponding opioid-related side effects. ..
  77. Langley K, Heron J, O Donovan M, Owen M, Thapar A. Genotype link with extreme antisocial behavior: the contribution of cognitive pathways. Arch Gen Psychiatry. 2010;67:1317-23 pubmed publisher
    ..The high-activity COMT genotype, in the presence of attention-deficit/hyperactivity disorder (ADHD), has previously been shown to be ..
  78. Spronk D, Arns M, Barnett K, Cooper N, Gordon E. An investigation of EEG, genetic and cognitive markers of treatment response to antidepressant medication in patients with major depressive disorder: a pilot study. J Affect Disord. 2011;128:41-8 pubmed publisher
    ..The 'Met/Met' variant of the COMT gene was the best genetic predictor of treatment outcome...
  79. Colilla S, Lerman C, Shields P, Jepson C, Rukstalis M, Berlin J, et al. Association of catechol-O-methyltransferase with smoking cessation in two independent studies of women. Pharmacogenet Genomics. 2005;15:393-8 pubmed
    The Val108/158Met polymorphism in the gene that encodes COMT, a dopamine metabolizing enzyme, results in a three- to four-fold reduction in COMT activity...
  80. Michaelovsky E, Frisch A, Leor S, Stein D, Danziger Y, Carel C, et al. Haplotype analysis of the COMT-ARVCF gene region in Israeli anorexia nervosa family trios. Am J Med Genet B Neuropsychiatr Genet. 2005;139B:45-50 pubmed
    ..Previously, we found an association between AN and the 158Val/Met polymorphism of the catechol-O-methyltransferase (COMT) gene in a family-based study of 51 Israeli AN trios...
  81. Benedetti F, Dallaspezia S, Colombo C, Lorenzi C, Pirovano A, Smeraldi E. Association between catechol-O-methyltransferase Val(108/158)Met polymorphism and psychotic features of bipolar disorder. J Affect Disord. 2010;125:341-4 pubmed publisher
    Catechol-O-methyltransferase (COMT) inactivates catecholamines, and a G-A transition in the COMT gene (rs4680) influences the enzyme activity and the interaction between cortical and subcortical dopaminergic neurotransmission...
  82. Alexander N, Osinsky R, Mueller E, Schmitz A, Guenthert S, Kuepper Y, et al. Genetic variants within the dopaminergic system interact to modulate endocrine stress reactivity and recovery. Behav Brain Res. 2011;216:53-8 pubmed publisher
    ..investigate combined effects of functional allelic variations that affect dopamine availability in both cortical (COMT Val¹??Met polymorphism) and subcortical (DAT1 VNTR) brain regions on HPA-axis reactivity to psychosocial stress...
  83. Hong C, Thompson H, Jiang C, Hammond G, Tritchler D, Yaffe M, et al. Val158Met Polymorphism in catechol-O-methyltransferase gene associated with risk factors for breast cancer. Cancer Epidemiol Biomarkers Prev. 2003;12:838-47 pubmed
    ..without breast cancer, we examined the relationship of a functional polymorphism in catechol-O-methyltransferase (COMT; VAL-->MET) to mammographic density and other risk factors for breast cancer...
  84. Montag C, Hartmann P, Merz M, Burk C, Reuter M. D2 receptor density and prepulse inhibition in humans: negative findings from a molecular genetic approach. Behav Brain Res. 2008;187:428-32 pubmed
    ..a sample of N=800 subjects according to their genotypes we tested the association between the DRD2 Taq Ia and the COMT Val158Met polymorphisms, and the magnitude of the eye-blink reflex in an acoustic PPI paradigm...
  85. Gaudet M, Bensen J, Schroeder J, Olshan A, Terry M, Eng S, et al. Catechol-O-methyltransferase haplotypes and breast cancer among women on Long Island, New York. Breast Cancer Res Treat. 2006;99:235-40 pubmed
    The gene encoding catechol-O-methyltransferase (COMT), critical to the inactivation of reactive catechol estrogens, has several single nucleotide polymorphisms (SNPs) that influence enzyme activity...
  86. Urata T, Takahashi N, Hakamata Y, Iijima Y, Kuwahara N, Ozaki N, et al. Gene-gene interaction analysis of personality traits in a Japanese population using an electrochemical DNA array chip analysis. Neurosci Lett. 2007;414:209-12 pubmed
    ..The present study investigated the relationship between the specific polymorphisms of MAO-A, COMT, DRD2, DRD3 and personality traits in Japanese women using a novel genotyping method involving electrochemical DNA ..
  87. Barnett J, Jones P, Robbins T, Muller U. Effects of the catechol-O-methyltransferase Val158Met polymorphism on executive function: a meta-analysis of the Wisconsin Card Sort Test in schizophrenia and healthy controls. Mol Psychiatry. 2007;12:502-9 pubmed
    The catechol-O-methyltransferase (COMT) Val(158)Met polymorphism is hypothesized to affect executive function in patient and control populations...
  88. Savitz J, van der Merwe L, Newman T, Stein D, Ramesar R. Catechol-o-methyltransferase genotype and childhood trauma may interact to impact schizotypal personality traits. Behav Genet. 2010;40:415-23 pubmed publisher
    ..Variants of catechol-o-methyltransferase (COMT) and four other dopamine pathway-related genes: DRD4, DRD2,MAOA, and SLC6A3, were typed...
  89. Swart M, Bruggeman R, Larøi F, Alizadeh B, Kema I, Kortekaas R, et al. COMT Val158Met polymorphism, verbalizing of emotion and activation of affective brain systems. Neuroimage. 2011;55:338-44 pubmed publisher
    Genetic variation in the catechol-O-methyltransferase (COMT) Val158Met polymorphism has been shown to influence performance on cognitive and emotional tasks...