chromogranin A

Summary

Gene Symbol: chromogranin A
Description: chromogranin A
Alias: CGA, chromogranin-A, SP-I, betagranin (N-terminal fragment of chromogranin A), catestatin, chromofungin, parathyroid secretory protein 1, pituitary secretory protein I
Species: human

Top Publications

  1. ncbi Chromogranin A as a biochemical marker for the management of neuroendocrine tumors: a multicenter study developed in Argentina
    Susana Haydée Belli
    Endocrine Division, Hospital C Durand, Ciudad Autonoma de Buenos Aires, Argentina
    Acta Gastroenterol Latinoam 39:184-9. 2009
  2. ncbi Gastric ECL-cell hyperplasia and carcinoids in rodents following chronic administration of H2-antagonists SK&F 93479 and oxmetidine and omeprazole
    G R Betton
    Smith Kline and French Research Ltd, Welwyn, Hertfordshire, England
    Toxicol Pathol 16:288-98. 1988
  3. ncbi pH- and Ca(2+)-induced conformational change and aggregation of chromogranin B. Comparison with chromogranin A and implication in secretory vesicle biogenesis
    S H Yoo
    Laboratory of Neurochemistry, NIDCD, National Institutes of Health, Bethesda, MD 20892 3320, USA
    J Biol Chem 270:12578-83. 1995
  4. pmc Mechanism of action of chromogranin A on catecholamine release: molecular modeling of the catestatin region reveals a beta-strand/loop/beta-strand structure secured by hydrophobic interactions and predictive of activity
    I Tsigelny
    Department of Medicine, Center for Molecular Genetics, University of California, San Diego, USA
    Regul Pept 77:43-53. 1998
  5. ncbi An 8-gene signature, including methylated and down-regulated glutathione peroxidase 3, of gastric cancer
    Xianglan Zhang
    Cancer Metastasis Research Center, Yonsei University College of Medicine, Seoul 120 752, Korea
    Int J Oncol 36:405-14. 2010
  6. doi Cutting edge: vasostatin-1-derived peptide ChgA29-42 is an antigenic epitope of diabetogenic BDC2.5 T cells in nonobese diabetic mice
    Enayat Nikoopour
    Centre for Human Immunology, University of Western Ontario, London, Ontario N6A 5C1, Canada
    J Immunol 186:3831-5. 2011
  7. doi Differences of molecular expression mechanisms among neural cell adhesion molecule 1, synaptophysin, and chromogranin A in lung cancer cells
    Korehito Kashiwagi
    Department of Pathology, Yokohama City University Graduate School of Medicine, Yokohama, Japan
    Pathol Int 62:232-45. 2012
  8. ncbi Interaction of early growth response protein 1 (Egr-1), specificity protein 1 (Sp1), and cyclic adenosine 3'5'-monophosphate response element binding protein (CREB) at a proximal response element is critical for gastrin-dependent activation of the chromog
    Raktima Raychowdhury
    Medizinische Klink mit Schwerpunkt Gastroenterologie, Hepatologie, Endokrinologie und Stoffwechsel, Universitatsklinikum Charite, Campus Virchow Klinikum, Humboldt Universitat, 13353 Berlin, Germany
    Mol Endocrinol 16:2802-18. 2002
  9. ncbi Gastrin transactivates the chromogranin A gene through MEK-1/ERK- and PKC-dependent phosphorylation of Sp1 and CREB
    Thorsten Cramer
    Laboratory for Angiogenesis and Tumor Metastasis, Charite Universitatsmedizin Berlin, Campus Virchow Klinikum, Germany
    Cell Signal 20:60-72. 2008
  10. pmc Identification of a chromogranin A domain that mediates binding to secretogranin III and targeting to secretory granules in pituitary cells and pancreatic beta-cells
    Masahiro Hosaka
    Department of Molecular Medicine, Institute for Molecular and Cellular Regulation, Gunma University, Maebashi, 371 8512, Japan
    Mol Biol Cell 13:3388-99. 2002

Research Grants

  1. PROCESSING OF CHROMOGRANIN A BY THE FIBRINOLYTIC SYSTEM
    ROBERT PARMER; Fiscal Year: 2001
  2. CHROMOGRANIN A--NICOTINIC SIGNALING AND DESENSITIZATION
    Sushil Mahata; Fiscal Year: 2001
  3. STIMULUS/TRANSCRIPTION COUPLING IN SYMPATHOADRENAL CELLS
    DANIEL O CONNOR; Fiscal Year: 1999
  4. SYNTHESIS OF DBH, CHROMOGRANINS AND CHROMAFFIN VESICLES
    NORMAN KIRSHNER; Fiscal Year: 1990
  5. Clinico-Genomic Assessment of Performance Status in Elderly AML Patients
    Arati V Rao; Fiscal Year: 2013
  6. Role of Chromogranin A in Metabolic Syndrome
    Sushil K Mahata; Fiscal Year: 2013
  7. Role of Dicer in Gonadotrope and Reproductive Function
    T Rajendra Kumar; Fiscal Year: 2013
  8. Tanner J Freeman; Fiscal Year: 2015
  9. Sucheta M Vaingankar; Fiscal Year: 2015
  10. Jonathan M Davis; Fiscal Year: 2016

Detail Information

Publications545 found, 100 shown here

  1. ncbi Chromogranin A as a biochemical marker for the management of neuroendocrine tumors: a multicenter study developed in Argentina
    Susana Haydée Belli
    Endocrine Division, Hospital C Durand, Ciudad Autonoma de Buenos Aires, Argentina
    Acta Gastroenterol Latinoam 39:184-9. 2009
    Elevated circulating levels of chromogranin A (CgA) are found in the neuroendocrine tumors (NETs), but diagnostic usefulness of this marker is still debatable...
  2. ncbi Gastric ECL-cell hyperplasia and carcinoids in rodents following chronic administration of H2-antagonists SK&F 93479 and oxmetidine and omeprazole
    G R Betton
    Smith Kline and French Research Ltd, Welwyn, Hertfordshire, England
    Toxicol Pathol 16:288-98. 1988
    ..Using morphometric analysis of immunoperoxidase anti-chromogranin A stained sections, a dose-related and time-dependent neuroendocrine ECL-cell hyperplasia was correlated with ..
  3. ncbi pH- and Ca(2+)-induced conformational change and aggregation of chromogranin B. Comparison with chromogranin A and implication in secretory vesicle biogenesis
    S H Yoo
    Laboratory of Neurochemistry, NIDCD, National Institutes of Health, Bethesda, MD 20892 3320, USA
    J Biol Chem 270:12578-83. 1995
    ..Similar to chromogranin A (CGA), which had been shown to undergo pH- and Ca(2+)-dependent conformational changes and to be composed of ..
  4. pmc Mechanism of action of chromogranin A on catecholamine release: molecular modeling of the catestatin region reveals a beta-strand/loop/beta-strand structure secured by hydrophobic interactions and predictive of activity
    I Tsigelny
    Department of Medicine, Center for Molecular Genetics, University of California, San Diego, USA
    Regul Pept 77:43-53. 1998
    A novel fragment of chromogranin A, known as 'catestatin' (bovine chromogranin A344-364), inhibits catecholamine release from chromaffin cells and noradrenergic neurons by acting as a non-competitive nicotinic cholinergic antagonist, and ..
  5. ncbi An 8-gene signature, including methylated and down-regulated glutathione peroxidase 3, of gastric cancer
    Xianglan Zhang
    Cancer Metastasis Research Center, Yonsei University College of Medicine, Seoul 120 752, Korea
    Int J Oncol 36:405-14. 2010
    ..Mechanism-wise GPX3 down-regulation in gastric cancer is due to promoter hypermethylation. Collectively, these results show a correct identification of 8 genes as gastric cancer biomarkers...
  6. doi Cutting edge: vasostatin-1-derived peptide ChgA29-42 is an antigenic epitope of diabetogenic BDC2.5 T cells in nonobese diabetic mice
    Enayat Nikoopour
    Centre for Human Immunology, University of Western Ontario, London, Ontario N6A 5C1, Canada
    J Immunol 186:3831-5. 2011
    ..The antigenic epitope of BDC2.5 TCR is absent in β cells that do not express chromogranin A (ChgA) protein. However, characterization of the BDC2.5 epitope in ChgA has given inconclusive results...
  7. doi Differences of molecular expression mechanisms among neural cell adhesion molecule 1, synaptophysin, and chromogranin A in lung cancer cells
    Korehito Kashiwagi
    Department of Pathology, Yokohama City University Graduate School of Medicine, Yokohama, Japan
    Pathol Int 62:232-45. 2012
    Neural cell adhesion molecule 1 (NCAM1), synaptophysin (SYPT), and chromogranin A (CGA) are immunohistochemical markers for diagnosing lung neuroendocrine tumors (LNETs)...
  8. ncbi Interaction of early growth response protein 1 (Egr-1), specificity protein 1 (Sp1), and cyclic adenosine 3'5'-monophosphate response element binding protein (CREB) at a proximal response element is critical for gastrin-dependent activation of the chromog
    Raktima Raychowdhury
    Medizinische Klink mit Schwerpunkt Gastroenterologie, Hepatologie, Endokrinologie und Stoffwechsel, Universitatsklinikum Charite, Campus Virchow Klinikum, Humboldt Universitat, 13353 Berlin, Germany
    Mol Endocrinol 16:2802-18. 2002
    ..to a GC-rich element at -92/-62 has been identified as a critical step in gastrin-dependent regulation of the chromogranin A (CgA) gene in gastric epithelial cells...
  9. ncbi Gastrin transactivates the chromogranin A gene through MEK-1/ERK- and PKC-dependent phosphorylation of Sp1 and CREB
    Thorsten Cramer
    Laboratory for Angiogenesis and Tumor Metastasis, Charite Universitatsmedizin Berlin, Campus Virchow Klinikum, Germany
    Cell Signal 20:60-72. 2008
    Our previous work revealed that gastrin regulates chromogranin A (CgA) transcription through enhanced binding of Sp1, CREB and Egr-1 to a proximal gastrin-responsive promoter element (Gas-RE)...
  10. pmc Identification of a chromogranin A domain that mediates binding to secretogranin III and targeting to secretory granules in pituitary cells and pancreatic beta-cells
    Masahiro Hosaka
    Department of Molecular Medicine, Institute for Molecular and Cellular Regulation, Gunma University, Maebashi, 371 8512, Japan
    Mol Biol Cell 13:3388-99. 2002
    b>Chromogranin A (CgA) is transported restrictedly to secretory granules in neuroendocrine cells. In addition to pH- and Ca(2+)-dependent aggregation, CgA is known to bind to a number of vesicle matrix proteins...
  11. ncbi Isolation and primary structure of a novel chromogranin A-derived peptide, WE-14, from a human midgut carcinoid tumour
    W J Curry
    Department of Medicine, Queen s University of Belfast, N Ireland, UK
    FEBS Lett 301:319-21. 1992
    The primary structure of a novel human chromogranin A-derived tetradecapeptide, WE-14, possessing N-terminal tryptophanyl (W) and C-terminal glutamyl (E) residues was isolated from a hepatic metastasis of an human ileal carcinoid tumour...
  12. pmc Proteolytic cleavage of human chromogranin a containing naturally occurring catestatin variants: differential processing at catestatin region by plasmin
    Nilima Biswas
    Department of Medicine, University of California San Diego School of Medicine and Veteran s Affairs San Diego Healthcare System, La Jolla, CA 92093 0838, USA
    Endocrinology 149:749-57. 2008
    The plasma level of chromogranin A (CgA) is elevated in genetic hypertension...
  13. ncbi Localization and characterization of evolutionarily conserved chromogranin A-derived peptides in the rat and human pituitary and adrenal glands
    Maite Montero-Hadjadje
    European Institute for Peptide Research IFRMP 23, INSERM U413, UA CNRS, University of Rouen, 76821 Mont Saint Aignan, France
    Cell Tissue Res 310:223-36. 2002
    b>Chromogranin A (CgA) is a neuroendocrine protein that undergoes proteolytic cleavage in secretory granules...
  14. doi Elevated chromogranin A (CgA) serum levels in the patients with advanced pancreatic cancer
    Michele Malaguarnera
    Department of Aging Sciences, Research Center on the Extreme Senescence, University of Catania, Via Messina, Catania, Italy
    Arch Gerontol Geriatr 48:213-7. 2009
    ..This study aimed at evaluating the clinical usefulness of CgA as a neuroendocrine (NE) serum-marker...
  15. pmc Hypertension from targeted ablation of chromogranin A can be rescued by the human ortholog
    Nitish R Mahapatra
    Department of Medicine, UCSD, San Diego, CA, USA
    J Clin Invest 115:1942-52. 2005
    The secretory prohormone chromogranin A (CHGA) is overexpressed in essential hypertension, a complex trait with genetic predisposition, while its catecholamine release-inhibitory fragment catestatin is diminished, and low catestatin ..
  16. ncbi Chromogranin A protects vessels against tumor necrosis factor alpha-induced vascular leakage
    Elisabetta Ferrero
    Department Biological and Technological Research DIBIT, San Raffaele H Scientific Institute, Via Olgettina 60, 20132 Milan, Italy
    FASEB J 18:554-6. 2004
    Elevated levels of circulating chromogranin A (CgA), a protein stored in the secretory granules of many neuroendocrine cells and neurons, have been detected in the blood of patients with neuroendocrine tumors or heart failure...
  17. doi Distribution of high chromogranin A serum levels in patients with nonmetastatic and metastatic prostate adenocarcinoma
    Alessandro Sciarra
    Department of Urology, University La Sapienza, Rome, Italy
    Urol Int 82:147-51. 2009
    We analyzed the incidence of elevated serum levels of chromogranin A (CgA) (as marker of neuroendocrine activity) in nonmetastatic and metastatic prostate cancer populations.
  18. pmc Chromogranin A polymorphisms are associated with hypertensive renal disease
    Rany M Salem
    Department of Medicine and Center for Molecular Genetics, University of California at San Diego and Veterans Administration San Diego Healthcare System 0838, 9500 Gilman Drive, La Jolla, CA 92093 0838, USA
    J Am Soc Nephrol 19:600-14. 2008
    b>Chromogranin A is released together with epinephrine and norepinephrine from catecholaminergic cells...
  19. pmc Common genetic variants in the chromogranin A promoter alter autonomic activity and blood pressure
    Y Chen
    Department of Medicine, Center for Human Genetics and Genomics, University of California at San Diego, San Diego, California 92093 0838, USA
    Kidney Int 74:115-25. 2008
    b>Chromogranin A (CHGA) is stored and released from the same secretory vesicles that contain catecholamines in chromaffin cells and noradrenergic neurons...
  20. ncbi Proteolytic cleavage of chromogranin A (CgA) by plasmin. Selective liberation of a specific bioactive CgA fragment that regulates catecholamine release
    Q Jiang
    Department of Medicine, University of California San Diego, 3350 La Jolla Village Dr, San Diego, CA 92161, USA
    J Biol Chem 276:25022-9. 2001
    b>Chromogranin A (CgA), the major soluble protein in catecholamine storage vesicles, serves as a prohormone that is cleaved into bioactive peptides that inhibit catecholamine release, providing an autocrine, negative feedback mechanism for ..
  21. doi Plasma chromogranin a in patients with inflammatory bowel disease
    Valentina Sciola
    Gastroenterology Unit II, Fondazione IRCCS Ospedale Maggiore Policlinico, Mangiagalli e Regina Elena, University of Milan, Milan, Italy
    Inflamm Bowel Dis 15:867-71. 2009
    Circulating chromogranin A (CgA) levels, a marker for neuroendocrine tumors including carcinoids, have recently been found elevated in some patients with inflammatory bowel disease (IBD), although their significance is unclear...
  22. doi The clinical relevance of chromogranin A as a biomarker for gastroenteropancreatic neuroendocrine tumors
    Ben Lawrence
    Gastrointestinal Pathobiology Research Group, Department of Surgery, Yale University School of Medicine, 310 Cedar Street, PO Box 208602, New Haven, CT 06520 8062, USA
    Endocrinol Metab Clin North Am 40:111-34, viii. 2011
    b>Chromogranin A, although it exhibits limitations, is currently the most useful general tumor biomarker available for use in the diagnosis and management of gastroenteropancreatic neuroendocrine tumors (NETs)...
  23. doi Chromogranin A is a reliable biomarker for gastroenteropancreatic neuroendocrine tumors in an Asian population of patients
    Wen Chi Chou
    Division of Hematology Oncology, Chang Gung Memorial Hospital at Linkou, Chang Gung University College of Medicine, No 5 Fushing St, Kweishan Shiang, Taoyuan, Taiwan, ROC
    Neuroendocrinology 95:344-50. 2012
    To evaluate the significance of plasma chromogranin A (CgA) levels in patients with gastroenteropancreatic neuroendocrine tumors (GEP-NET) in terms of disease status and treatment responses.
  24. pmc Elevated serum levels of Chromogranin A in hepatocellular carcinoma
    Antonio Biondi
    Department of General Surgery, Section of General Surgery and Oncology, Vittorio Emanuele Hospital, Via Plebiscito 628 University of Catania, 95123 Catania, Italy
    BMC Surg 12:S7. 2012
    ..has been observed in some tumor cells within some hepatocellular carcinoma nodules and elevated serum chromogranin A also been reported in patients with hepatocellular carcinoma...
  25. doi Chromogranin A and neuron-specific enolase as prognostic markers in patients with advanced pNET treated with everolimus
    James C Yao
    Department of Gastrointestinal Medical Oncology, The University of Texas M D Anderson Cancer Center, 1515 Holcombe Boulevard, Box 426, Houston, Texas 77030, USA
    J Clin Endocrinol Metab 96:3741-9. 2011
    ..b>Chromogranin A (CgA) and neuron-specific enolase (NSE) are considered general biomarkers of these tumors.
  26. pmc Naturally occurring human genetic variation in the 3'-untranslated region of the secretory protein chromogranin A is associated with autonomic blood pressure regulation and hypertension in a sex-dependent fashion
    Yuqing Chen
    Department of Medicine, Center for Human Genetics and Genomics, University of California at San Diego, San Diego, California 92093, USA
    J Am Coll Cardiol 52:1468-81. 2008
    We aimed to determine whether the common variation at the chromogranin A (CHGA) locus increases susceptibility to hypertension.
  27. ncbi Heredity of endothelin secretion: human twin studies reveal the influence of polymorphism at the chromogranin A locus, a novel determinant of endothelial function
    Elizabeth O Lillie
    Department of Medicine, University of California at San Diego, USA
    Circulation 115:2282-91. 2007
    ..b>Chromogranin A (CHGA) regulates the storage and release of catecholamines and may have direct actions on the microvasculature...
  28. ncbi [Plasma chromogranin-A (CgA)--a potential marker for diagnosis, monitoring and management of prostate cancer patients]
    Ilan Leibovitch
    Department of Urology, Meir Medical Center, Kfar Saba
    Harefuah 145:25-9, 78. 2006
    ..Circulating CgA levels were shown to reflect neuroendocrine differentiation and were found to correlate with the stage and the ..
  29. doi Knockdown of Pdcd4 results in induction of proprotein convertase 1/3 and potent secretion of chromogranin A and secretogranin II in a neuroendocrine cell line
    Brigitte Lankat-Buttgereit
    Faculty of Medicine, Department of Gastroenterology, Endocrinology and Metabolism, University of Marburg, Baldingerstrasse, D 35033 Marburg, Germany
    Biol Cell 100:703-15. 2008
    ..To gain further insights into its biological functions, we suppressed Pdcd4 expression in the neuroendocrine cell line Bon-1 via siRNA (small interfering RNA) technology...
  30. ncbi The primary structure of human chromogranin A and pancreastatin
    D S Konecki
    Cell Biology Programme, European Molecular Biology Laboratory, Heidelberg, Federal Republic of Germany
    J Biol Chem 262:17026-30. 1987
    A full-length clone encoding human chromogranin A has been isolated from a lambda gt10 cDNA library of a human pheochromocytoma...
  31. pmc Effects of chromogranin A deficiency and excess in vivo: biphasic blood pressure and catecholamine responses
    Sucheta M Vaingankar
    Department of Medicine, University of California at San Diego, and Veterans Affairs San Diego Healthcare System, La Jolla, California 92093 0838, USA
    J Hypertens 28:817-25. 2010
    The phenotype of the chromogranin A (Chga) null (knockout) mouse is hypertensive. However, hypertensive humans and spontaneously hypertensive rats display elevated CHGA expression...
  32. pmc Chromogranin A regulates renal function by triggering Weibel-Palade body exocytosis
    Yuqing Chen
    Department of Medicine, University of California at San Diego, La Jolla, CA 92093 0838, USA
    J Am Soc Nephrol 20:1623-32. 2009
    b>Chromogranin A (CHGA), a protein released from secretory granules of chromaffin cells and sympathetic nerves, triggers endothelin-1 release from endothelial cells...
  33. pmc Both rare and common polymorphisms contribute functional variation at CHGA, a regulator of catecholamine physiology
    Gen Wen
    Department of Medicine, University of California San Diego School of Medicine, La Jolla, CA 92093, USA
    Am J Hum Genet 74:197-207. 2004
    ..b>Chromogranin A (CHGA) regulates catecholamine storage and release through intracellular (vesiculogenic) and extracellular (..
  34. doi The prognostic role of immunohistochemical chromogranin a expression in prostate cancer patients is significantly modified by androgen-deprivation therapy
    Alfredo Berruti
    Oncologia Medica, Dipartimento di Scienze Cliniche e Biologiche, Universita di Torino, Torino, Italy
    Prostate 70:718-26. 2010
    ..This study was undertaken to assess the prognostic role of tissue chromogranin A (CgA) expression in patients addressed to ADT as opposed to those who did not.
  35. pmc A common genetic variant in the 3'-UTR of vacuolar H+-ATPase ATP6V0A1 creates a micro-RNA motif to alter chromogranin A processing and hypertension risk
    Zhiyun Wei
    Departments of Medicine and Pharmacology, Institute for Genomic Medicine, University of California at San Diego, the VA San Diego Healthcare System, La Jolla, USA
    Circ Cardiovasc Genet 4:381-9. 2011
    The catecholamine release-inhibitor catestatin and its precursor chromogranin A (CHGA) may constitute "intermediate phenotypes" in the analysis of genetic risk for cardiovascular disease such as hypertension...
  36. ncbi Antibacterial activity of glycosylated and phosphorylated chromogranin A-derived peptide 173-194 from bovine adrenal medullary chromaffin granules
    J M Strub
    INSERM, Unité 338 de Biologie de la Communication Cellulaire, Strasbourg, 67084 France
    J Biol Chem 271:28533-40. 1996
    ..Here, we characterize a large natural fragment, corresponding to chromogranin A 79-431, that inhibits growth of both Gram-positive and Gram-negative bacteria...
  37. ncbi Endothelium-derived nitric oxide mediates the antiadrenergic effect of human vasostatin-1 in rat ventricular myocardium
    Maria Pia Gallo
    Dipartimento di Biologia Animale e dell Uomo, Universita di Torino, Italy
    Am J Physiol Heart Circ Physiol 292:H2906-12. 2007
    Vasostatins (VSs) are vasoactive peptides derived from chromogranin A (CgA), a protein contained in secretory granules of chromaffin and other cells...
  38. ncbi Chromogranins--new sensitive markers for neuroendocrine tumors
    B Eriksson
    Ludwig Institute for Cancer Research, Biomedical Center, Uppsala, Sweden
    Acta Oncol 28:325-9. 1989
    ..We examined the secretion of chromogranin A and chromogranin A + B by hormone-producing tumors in patients with endocrine pancreatic tumors (EPT), ..
  39. pmc Localisation of chromogranin A and B, met-enkephalin-arg6-gly7-leu8 and PGP9.5-like immunoreactivity in the developing and adult rat adrenal medulla and extra-adrenal chromaffin tissue
    C Kent
    Department of Human Morphology, University of Nottingham Medical School, Queen s Medical Centre, U K
    J Anat 166:213-25. 1989
    ..In the adult rat adrenal the cytoplasm of all medullary chromaffin cells showed a positive response with chromogranin A and B; in each case occasional groups of cells with a low reactivity that may have been NA cells were seen...
  40. ncbi Atypical carcinoid tumor of the larynx: an immunohistochemical, ultrastructural, and flow cytometric analysis
    W G McCluggage
    Department of Pathology, Royal Group of Hospitals Trust, Belfast, Northern Ireland
    Ultrastruct Pathol 21:431-8. 1997
    ..2, CEA, chromogranin A, and calcitonin...
  41. ncbi Neuroendocrine pancreatic tumors. Clinical findings in a prospective study of 84 patients
    B Eriksson
    Ludwig Institute for Cancer Research, University Hospital, Uppsala, Sweden
    Acta Oncol 28:373-7. 1989
    ..Plasma chromogranin A + B was elevated in 94%, serum pancreatic polypeptide (PP) in 74%, plasma neurotensin in 67% and serum gastrin ..
  42. ncbi In vitro culture of neuroendocrine tumors of the pancreas and gut
    M Lundqvist
    Ludwig Institute for Cancer Research, University Hospital, Uppsala, Sweden
    Acta Oncol 28:335-9. 1989
    ..This observation correlated to positive immunostaining to chromogranin A and synaptophysin...
  43. doi Chromogranin B gene ablation reduces the catecholamine cargo and decelerates exocytosis in chromaffin secretory vesicles
    Jésica Díaz-Vera
    Unit of Pharmacology, Medical School, La Laguna University, 38071 La Laguna, Tenerife, Spain
    J Neurosci 30:950-7. 2010
    ..We have recently reported that the absence of chromogranin A (CgA) caused important changes in the accumulation and in the exocytosis of catecholamines (CAs) using a CgA-..
  44. ncbi Pulmonary blastoma: an ultrastructural and immunohistochemical study with special reference to nuclear filament aggregation
    P Yang
    First Department of Pathology, University of Tokushima School of Medicine, Japan
    Ultrastruct Pathol 19:501-9. 1995
    ..5, chromogranin A, calcitonin, and Ki-67 (MIB-1); the mesenchymal cells were immunoreactive for vimentin, actin, cytokeratins, ..
  45. ncbi Chromogranin A: posttranslational modifications in secretory granules
    J A Barbosa
    Department of Medicine, University of California, San Diego
    Endocrinology 128:174-90. 1991
    The primary structure of chromogranin A indicates multiple domains which might be subject to posttranslational modification...
  46. pmc Praomys (Mastomys) natalensis: a model for gastric carcinoid formation
    O Nilsson
    Department of Histology, , Sweden
    Yale J Biol Med 65:741-51; discussion 827-9. 1992
    ..gastric carcinoids are endocrine in nature, as evidenced by their argyrophilic staining properties and chromogranin A content...
  47. ncbi Characterisation of N-terminal chromogranin A and chromogranin B in mammals by region-specific radioimmunoassays and chromatographic separation methods
    M Stridsberg
    Department of Medical Sciences, Clinical Chemistry, University Hospital, S 751 85 Uppsala, Sweden
    J Endocrinol 165:703-14. 2000
    b>Chromogranin A (CgA) and chromogranin B (CgB) are acidic proteins stored in and released from hormone granules in endocrine and neuroendocrine tissue...
  48. doi The crucial role of chromogranins in storage and exocytosis revealed using chromaffin cells from chromogranin A null mouse
    Monica S Montesinos
    Unit of Pharmacology, Medical School, University of La Laguna, 38071 Tenerife, Spain
    J Neurosci 28:3350-8. 2008
    ..Chromaffin cells from Chga null mice [chromogranin A knock-out (CgA-KO)] exhibited approximately 30% reduction in the content and in the release of catecholamines ..
  49. ncbi Diagnostic pathology of gastrointestinal and pancreatic neuroendocrine tumours
    E Wilander
    Department of Pathology, University Hospital, Uppsala, Sweden
    Acta Oncol 28:363-9. 1989
    ..such as the argyrophil reaction of Grimelius and immunohistochemistry with application of antibodies against chromogranin A and of neuron-specific enolase are discriminatory staining methods which are used to reveal the neuroendocrine ..
  50. ncbi Localization of three types of the inositol 1,4,5-trisphosphate receptor/Ca(2+) channel in the secretory granules and coupling with the Ca(2+) storage proteins chromogranins A and B
    S H Yoo
    National Creative Research Initiative Center for Secretory Granule Research, Korea Advanced Institute of Science and Technology, Yu Sung Gu, Dae Jeon, Korea 305 701
    J Biol Chem 276:45806-12. 2001
    ..To determine whether these IP(3)Rs interact with CGA and CGB, each IP(3)R isoform was co-transfected with CGA or CGB into NIH3T3 or COS-7 cells, and the expressed IP(3)..
  51. ncbi Chromogranin-A expression in the bovine testis
    Rita Payan-Carreira
    Zootecnia Department, CECAV, University of Tras os Montes and Alto Douro, P O Box 1013, 5001 911 Vila Real, Portugal
    Anim Reprod Sci 96:146-53. 2006
    Chromogranin-A (CgA) is the most distributed member of the granin family...
  52. ncbi A functional interaction between chromogranin B and the inositol 1,4,5-trisphosphate receptor/Ca2+ channel
    Edwin C Thrower
    Department of Pharmacology and Cellular and Molecular Physiology, Yale University, New Haven, Connecticut 06520, USA
    J Biol Chem 278:49699-706. 2003
    Chromogranins A and B (CGA and CGB) are high capacity, low affinity calcium (Ca2+) storage proteins found in many cell types most often associated with secretory granules of secretory cells but also with the endoplasmic reticulum (ER) ..
  53. doi Chromogranin A assay in clinical practice
    M D'Herbomez
    Departement de Medecine Nucleaire, Centre de Biologie Pathologie, CHRU, 59037 Lille Cedex, France
    Ann Endocrinol (Paris) 71:274-80. 2010
    ..They are found in secretory vesicles throughout the neuroendocrine system. Chromogranin A (CgA) is the main component...
  54. ncbi Inositol 1,4,5-trisphosphate receptor/Ca2+ channel modulatory role of chromogranin A, a Ca2+ storage protein of secretory granules
    S H Yoo
    National Creative Research Initiative Center for Secretory Granule Research, Biomedical Research Center, Korea Advanced Institute of Science and Technology, Yu Sung Gu, 305 701 Dae Jeon, Korea
    J Biol Chem 275:15067-73. 2000
    ..In our previous study, chromogranin A (CGA) was shown to interact with several secretory granule membrane proteins, including the IP(3) receptor (IP(..
  55. ncbi High frequency of ras mutations in forestomach and lung tumors of B6C3F1 mice exposed to 1-amino-2,4-dibromoanthraquinone for 2 years
    S Hayashi
    Laboratory of Experimental Pathology, National Institute of Environmental Health Sciences, Research Triangle Park, NC 27709, USA
    Toxicol Pathol 29:422-9. 2001
    ..H-ras codon 61 CGA mutation (6/24, 25%) was also detected in ADBAQ-induced forestomach squamous cell carcinomas...
  56. ncbi 17 alpha-Hydroxylase and chromogranin A in 6th week human fetal adrenals
    M Ehrhart-Bornstein
    Department of Internal Medicine III, University of Leipzig, Germany
    Horm Metab Res 29:30-2. 1997
    ..In parallel, chromaffin cells were characterized by immunohistochemical staining for chromogranin A, the major soluble protein in adrenal chromaffin granules...
  57. ncbi [Subtype and sequence analysis of the C2-V3 region of gp120 genes among human immunodeficiency virus infected IDUs in Ruili epidemic area of Yunnan Province of China]
    Y Guan
    Institute of Virology, Chinese Academy of Preventive Medicine, Beijing 100052
    Zhonghua Shi Yan He Lin Chuang Bing Du Xue Za Zhi 11:8-12. 1997
    ..In addition, the codon of arginine (R) of all the strains is CGA instead of AGA...
  58. pmc Hypergastrinemia and enterochromaffin-like cell hyperplasia
    G Delle Fave
    Cattedra di Gastroenterologia, , Rome, Italy
    Yale J Biol Med 71:291-301. 1998
    ..from each group was further investigated by meal-stimulation of gastrin secretion and quantitative morphometry for CgA positive gastric body endocrine cells. Results: AGCH patients showed only the normal or simple hyperplasia pattern...
  59. ncbi Middle ear adenoma is an amphicrine tumor: why call it adenoma?
    S Ketabchi
    Dipartimento di Patologia Umana ed Oncologia, Universita degli Studi di Firenze, Italia
    Ultrastruct Pathol 25:73-8. 2001
    ..neoplastic cells diffusely stained with anti-vimentin antibodies and were focally positive for chromogranin A, neuron-specific enolase, lysozyme, and cytokeratins AE1/AE3...
  60. ncbi Quantitation of glandular gastric changes in rats given a proton pump inhibitor for 3 months with emphasis on sampling scheme selection
    S L White
    Toxicology Research Laboratories, Lilly Research Laboratories, Greenfield, Indiana 46140, USA
    Toxicol Pathol 26:403-10. 1998
    ..Histologic sections of glandular stomach, stained for chromogranin A, were evaluated by image analysis to determine stomach mucosal thickness, mucosal and nonmucosal (submucosa ..
  61. ncbi Diagnostic immunoelectron microscopy in surgical pathology: assessment of various tissue fixation and processing protocols
    S L Mount
    Department of Pathology, University of Vermont, Burlington 05405
    Ultrastruct Pathol 17:547-56. 1993
    ..small bowel mucosa was processed using seven different methods for subsequent postembedding localization of chromogranin A. In addition, several archival cases of neuroendocrine tumors previously fixed and routinely embedded for ..
  62. ncbi High survival rate of 6 cases of pulmonary large cell neuroendocrine carcinoma formerly classified as small cell carcinoma
    M Yamanishi
    Department of Pathology (I, Nippon Medical School, 1-1-5 Sendagi, Bunkyo-ku, Tokyo 113-8602, Japan
    J Nippon Med Sch 68:335-9. 2001
    ..Their neuroendocrine differentiations were confirmed by the use of immunostainings with chromogranin A and synaptophysin...
  63. ncbi Immunohistochemical and ultrastructural investigation of neural differentiation in Ewing sarcoma/PNET of bone and soft tissues
    A Franchi
    Dipartimento di Patologia Umana ed Oncologia, , Italy
    Ultrastruct Pathol 25:219-25. 2001
    ..panel of primary antibodies used included vimentin, MIC-2, NSE, S-100 protein, leu7, neurofilaments, GFAP, and chromogranin A. Cases were considered undifferentiated when neural markers were absent, poorly differentiated if one neural ..
  64. ncbi Melanotic neuroectodermal tumor of infancy occurring in the left thigh of a 6-month-old female infant
    O Scheck
    Institute of Pathology, Eberhard Karls University, , Federal Republic of Germany
    Ultrastruct Pathol 13:23-33. 1989
    ..Although dense-core granules were demonstrated ultrastructurally in some neuroblasts, no immunostaining for chromogranin A, Leu-7, serotonin, or regulatory peptides was found...
  65. ncbi Characterization and uptake of radiolabelled meta-iodobenzylguanidine (MIBG) in a human neuroblastoma heterotransplant model in athymic rats
    S Nilsson
    Department of Oncology, University Hospital, Uppsala, Sweden
    Acta Oncol 32:887-91. 1993
    ..neuronal phenotype of the cultured cells, as evidenced by the expression of neuron-specific enolase (NSE) and chromogranin A + B...
  66. ncbi Immunoelectron microscopy for chromogranin A in small cell neuroendocrine carcinoma of lung
    I Dardick
    Department of Pathology, Toronto Hospital, Ontario, Canada
    Ultrastruct Pathol 20:361-8. 1996
    ..microscopy can improve localization of neurosecretory granules, postembedding immunolabelling for chromogranin A was performed on 15 examples of small cell anaplastic (neuroendocrine) carcinomas primary in lung, five cases ..
  67. pmc Physiology of the ECL cells
    R Hakanson
    Department of Pharmacology, University of Lund, Sweden
    Yale J Biol Med 71:163-71. 1998
    ..ECL) cells of the oxyntic mucosa (fundus) of the stomach produce, store and secrete histamine, chromogranin A-derived peptides such as pancreastatin, and an unanticipated but as yet unidentified peptide hormone...
  68. ncbi Chromogranin A and pancreastatin-like immunoreactivity in serum of gastrinoma patients
    U Syversen
    Institute of Cancer Research, University of Trondheim, Norway
    Acta Oncol 32:161-5. 1993
    Gastrin and pancreastatin-like immunoreactivity were determined by radioimmunoassay methods and chromogranin A was determined by enzyme-linked immunoassay in sera from 18 patients with gastrinomas (Zollinger-Ellison syndrome) and in 20 ..
  69. ncbi Solid and papillary neoplasm of the pancreas
    L J Jørgensen
    Department of Pathology and Surgical Gastroenterology, Hvidovre Hospital, Denmark
    Ultrastruct Pathol 16:659-66. 1992
    ..Its low malignant potential compared to ductal adenocarcinoma is reflected in the mean nuclear volume and volume-corrected mitotic index. The presence of estrogen receptors may prove therapeutically useful...
  70. ncbi [Expression of CD56, as a potential diagnostic marker, in small cell carcinoma]
    Jing Ping Yun
    State Key Laboratory of Oncology in Southern China, Guangzhou, Guangdong, P R China
    Ai Zheng 24:1140-3. 2005
    ..by using routine neuroendocrinal markers, such as neuron-specific enolase (NSE), synaptophysin (SYN), chromogranin A (CgA)...
  71. ncbi Gastrinomas associated with MEN-1 syndrome: new insights for the diagnosis and management in a series of 11 patients
    George C Nikou
    Section of Gastrointestinal Neuroendocrinology, First Department of Propaedeutic Internal Medicine, Athens University Medical School, Laiko Hospital, Greece
    Hepatogastroenterology 52:1668-76. 2005
    ..Among 33 pts with ZES, we present in this study 11 pts with ZES and MEN-1 syndrome, describing our diagnostic and therapeutic approach...
  72. pmc Ontogeny of ECL cells in the rat
    F Sundler
    Department of Physiology and Neuroscience, Lund University, Sweden
    Yale J Biol Med 71:155-61. 1998
    ECL cells produce histamine and chromogranin A, and are restricted to the oxyntic mucosa of the stomach. ECL cell ontogeny has been studied in some detail in the rat...
  73. ncbi Influence of chemical treatments on glutathione S-transferases of maize with activity towards metolachlor and cinnamic acid
    C K Cottingham
    Department of Biology, Frederick Community College, Maryland 21702, USA
    Z Naturforsch C 53:973-9. 1998
    ..soluble and membrane-bound GST activity by the safener benoxacor, the herbicide metolachlor and their combination (CGA-180937) were investigated...
  74. ncbi Chromogranin A: is it a useful marker of neuroendocrine tumors?
    Davide Campana
    Department of Internal Medicine and Gastroenterology, University of Bologna, Policlinico S Orsola Malpighi, Bologna, Italy
    J Clin Oncol 25:1967-73. 2007
    We evaluated the pattern of chromogranin A (CgA) plasma levels in a large number of patients with neuroendocrine tumors (NETs), in a series of patients with chronic atrophic gastritis (CAG) with and without enterochromaffin-like (ECL) ..
  75. ncbi [Influence of long-term gastric acid suppression therapy on the expression of serum gastrin, chromogranin A, and ghrelin]
    Byung Wook Kim
    Department of Internal Medicine, College of Medicine, The Catholic University of Korea, Seoul, Korea
    Korean J Gastroenterol 53:84-9. 2009
    ..The aim of this study was to identify the effect of long-term gastric acid suppression on the gastric peptides levels, such as gastrin, chromogranin A, or ghrelin.
  76. ncbi Chromogranin-A expression in neoplastic neuroendocrine cells and prognosis in colorectal cancer
    G B Secco
    Instituto di Patologia Chirurgica, , Italy
    Tumori 82:390-3. 1996
    ..3%) and CG-negative (30%) tumors. CONCLUSIONS: CG expression cannot, at present, be recommended as a marker to identify prognostic subgroups in colorectal cancer patients...
  77. ncbi The release of chromogranin A and B like activity from human lung cancer cell lines. A potential marker for a subset of small cell lung cancer
    J Bergh
    Department of Oncology, Ludwig Institute for Cancer Research, University of Uppsala, Akademiska sjukhuset, Sweden
    Acta Oncol 28:651-4. 1989
    ..In this paper we report on the release to the culture medium of neuroendocrine associated proteins, chromogranin A and B like activity (CABLA)...
  78. ncbi Is physiologic sympathoadrenal catecholamine release exocytotic in humans?
    M A Takiyyuddin
    Department of Medicine, University of California, San Diego
    Circulation 81:185-95. 1990
    In cultured cells and isolated perfused organs, catecholamines are coreleased with chromogranin A (CgA) from adrenal chromaffin cells and sympathetic neurons...
  79. ncbi Seasonal exposures to triazine and other pesticides in surface waters in the western Highveld corn-production region in South Africa
    L H Du Preez
    School of Environmental Sciences and Development, North West University, Potchefstroom Campus, Private Bag X6001, Potchefstroom 2520, South Africa
    Environ Pollut 135:131-41. 2005
    ..in surface water from eight ponds, three in a non-corn-growing area (NCGA) and five within the corn-growing area (CGA). Measured atrazine concentrations differed significantly among sites and between samples...
  80. ncbi Lessons to be learned: a case study approach. Paraganglioma of the urinary bladder
    M Dewan
    Asir Central Hospital, Post Box 34, Abha, Asir Region, Saudi Arabia
    J R Soc Promot Health 121:193-8. 2001
    ..The endocrine markers chromogranin A and neuron-specific enolase were positive in chief cells; sustentacular cells at the periphery of neoplastic ..
  81. ncbi Pancreastatin--a novel regulatory peptide?
    W E Schmidt
    Department of Medicine, Georg August University of Gottingen, Germany
    Acta Oncol 30:441-9. 1991
    ..It is derived by proteolytic processing from chromogranin A, an acidic protein component of secretory granules in endocrine and neuronal cells...
  82. ncbi Somatostatin receptor scintigraphy versus chromogranin A assay in the management of patients with neuroendocrine tumors of different types: clinical role
    M Cimitan
    Nuclear Medicine Unit, National Cancer Institute CRO IRCCS, Aviano, Italy
    Ann Oncol 14:1135-41. 2003
    ..diagnosis and staging of neuroendocrine tumors (NETs) are significantly improved by the introduction of the chromogranin A (CgA) assay in plasma or serum as a tumor marker, and by the use of somatostatin receptor scintigraphy (SRS) ..
  83. doi Plasma chromogranin A as marker for survival in patients with metastatic endocrine gastroenteropancreatic tumors
    Rudolf Arnold
    Department of Internal Medicine, Division of Gastroenterology and Endocrinology, Philipps University, Marburg, Germany
    Clin Gastroenterol Hepatol 6:820-7. 2008
    The prognostic role of plasma chromogranin A in patients with neuroendocrine tumors is unclear...
  84. ncbi Plasma chromogranin A in patients with sporadic gastro-entero-pancreatic neuroendocrine tumors or multiple endocrine neoplasia type 1
    M Peracchi
    Institute of Endocrine Sciences, University of Milan, Ospedale Maggiore IRCCS, Padiglione Granelli, Via F Sforza 35, 20122, Milan, Italy
    Eur J Endocrinol 148:39-43. 2003
    As circulating chromogranin A (CgA) has been claimed to be the best general neuroendocrine marker so far available, we evaluated the usefulness of CgA determination in the clinical assessment of patients with sporadic gastro-entero-..
  85. ncbi Secretin-cells of the mammalian intestine contain serotonin
    Y Cetin
    Abteilung Anatomie I der Medizinischen Hochschule Hannover, Federal Republic of Germany
    Histochemistry 93:601-6. 1990
    ..Moreover, it was presumed that chromogranin A, an acidic glycoprotein, is involved in storage mechanisms for biogenic amines in endocrine cells...
  86. pmc Correlation of three immunohistochemically detected markers of neuroendocrine differentiation with clinical predictors of disease progression in prostate cancer
    M Hammad Ather
    Department of Surgery, Aga Khan University, Karachi, Pakistan
    BMC Urol 8:21. 2008
    ..e. Chromogranin A (CgA), Neuron specific enolase (NSE) and Synaptophysin (Syn)...
  87. doi Chromogranin A as an alternative to 5-hydroxyindoleacetic acid in the evaluation of symptoms during treatment of patients with neuroendocrine Tumors
    Catharina M Korse
    Department of Clinical Chemistry, The Netherlands Cancer Institute Antoni van Leeuwenhoek Hospital, Amsterdam, The Netherlands
    Neuroendocrinology 89:296-301. 2009
    ..b>Chromogranin A (CgA) is a promising marker, but a thorough evaluation during follow-up is still lacking.
  88. ncbi Comparison of plasma pancreastatin and GAWK concentrations, presumed processing products of chromogranin A and B, in plasma of patients with pancreatic islet cell tumors
    D Yasuda
    Department of Gastroenterology, National Kyushu Cancer Center, Fukuoka, Japan
    Horm Metab Res 25:593-5. 1993
    Plasma pancreastatin (PST) and GAWK, peptides processed from chromogranin A and B, were elevated in patients with various neuroendocrine tumors...
  89. ncbi Serum chromogranin-alpha immunoradiometric assay in the diagnosis of pheochromocytoma
    L Giovanella
    Department of Nuclear Medicine, University Hospital Ospedale di Circolo e Fondazione Macchi, Varese, Italy
    Int J Biol Markers 17:130-4. 2002
    ..b>Chromogranin A (CgA) is a member of the granin family and is widely distributed in neuroendocrine cells and particularly in ..
  90. ncbi Immunohistochemical study of neuroendocrine differentiation in primary glandular lesions and tumors of the urinary bladder
    Enrico R Bollito
    Division of Pathology, San Luigi Gonzaga Hospital, Orbassano, Italy
    Anal Quant Cytol Histol 27:218-24. 2005
    ..Neuroendocrine (NE) cells are uncommon in primary adenocarcinoma (AC) and other glandular lesions of the bladder, with no recent study series concerning its significance in differential diagnosis, prognosis or biologic significance...
  91. ncbi Chromogranin 'A' in normal subjects, essential hypertensives and adrenalectomized patients
    Bernini Giampaolo
    Department of Internal Medicine, University of Pisa, Italy
    Clin Endocrinol (Oxf) 57:41-50. 2002
    b>Chromogranin A (CgA) is an acidic glycoprotein co-stored in vesicles and co-released with catecholamines...
  92. ncbi Proteolytic processing of chromogranin A in cultured chromaffin cells
    J P Simon
    Groupe de Neurobiologie Structurale et Fonctionelle, Unité INSERM U 44, Strasbourg, France
    Biochim Biophys Acta 1051:123-30. 1990
    The prohormone chromogranin A is the major soluble component of secretory granules in chromaffin cells of adrenal medulla and in many other different endocrine cell types...
  93. ncbi Primary sequence characterization of catestatin intermediates and peptides defines proteolytic cleavage sites utilized for converting chromogranin a into active catestatin secreted from neuroendocrine chromaffin cells
    Jean C Lee
    The Buck Institute for Age Research, Novato, California 94945, USA
    Biochemistry 42:6938-46. 2003
    Catestatin is an active 21-residue peptide derived from the chromogranin A (CgA) precursor, and catestatin is secreted from neuroendocrine chromaffin cells as an autocrine regulator of nicotine-stimulated catecholamine release...
  94. pmc Plasma chromogranin A marks emesis and serotonin release associated with dacarbazine and nitrogen mustard but not with cyclophosphamide-based chemotherapies
    L X Cubeddu
    Department of Pharmacology, School of Pharmacy, Central University of Venezuela, Caracas
    Br J Cancer 72:1033-8. 1995
    b>Chromogranin A (CgA) is present in high concentrations in enterochromaffin cells, where it is co-localised with serotonin in the storage granules...
  95. ncbi Comprehensive geriatric assessment in female elderly patients with Alzheimer disease and other types of dementia
    D Riccio
    Cattedra di Oncologia Medica, Policlinico Universitario, SS 554 Bivio per Sestu, I 09100 Cagliari, Italy
    Arch Gerontol Geriatr 44:343-53. 2007
    ..The comprehensive geriatric assessment (CGA) is the validated and recommended instrument to a correct evaluation and decision making in elderly patients...
  96. pmc A new human chromogranin A (CgA) immunoradiometric assay involving monoclonal antibodies raised against the unprocessed central domain (145-245)
    F Degorce
    CIS Biointernational, Division In Vitro Technologies, , France
    Br J Cancer 79:65-71. 1999
    b>Chromogranin A (CgA), a major protein of chromaffin granules, has been described as a potential marker for neuroendocrine tumours...
  97. doi Evaluation of chromogranin A determined by three different procedures in patients with benign diseases, neuroendocrine tumors and other malignancies
    Rafael Molina
    Oncobiology Unit, Laboratory of Biochemistry, Hospital Clinic of Barcelona, C Villarroel 170, Barcelona, 08036, Spain
    Tumour Biol 32:13-22. 2011
    b>CgA is a tumor marker in NET's (neuroendocrine tumors) but different ranges of sensitivity and specificity according to the commercial assay kits used have been reported...
  98. doi Chlorogenic acid suppresses pulmonary eosinophilia, IgE production, and Th2-type cytokine production in an ovalbumin-induced allergic asthma: activation of STAT-6 and JNK is inhibited by chlorogenic acid
    Hye Rin Kim
    Department of Biology, Changwon National University, 9, Sarim dong, Changwon, Kyungnam 641 773, South Korea
    Int Immunopharmacol 10:1242-8. 2010
    ..Chlorogenic acid (CGA), an ester of caffeic acid with quinic acid, is one of the most abundant polyphenol compounds in various ..
  99. pmc Cathepsin L colocalizes with chromogranin a in chromaffin vesicles to generate active peptides
    Nilima Biswas
    Department of Medicine 0838, University of California, San Diego, La Jolla, California 92093 0838, USA
    Endocrinology 150:3547-57. 2009
    b>Chromogranin A (CgA), the major soluble protein in chromaffin granules, is proteolytically processed to generate biologically active peptides including the catecholamine release inhibitory peptide catestatin...
  100. ncbi [Study on pathological features and diagnosis, differential diagnosis of olfactory neuroblastoma]
    Hong gang Liu
    Department of Pathology, Beijing Tongren Hospital Affiliated to Capital University of Medical Sciences, Beijing 100730, China
    Zhonghua Bing Li Xue Za Zhi 32:432-6. 2003
    ..To observe the common characteristics of pathological morphology and immunohistochemical staining of olfactory neuroblastoma (ONB), and to raise the diagnostic ability for ONB...
  101. doi Clinical features of canine granulocytic anaplasmosis in 18 naturally infected dogs
    B Kohn
    Clinic for Small Animals, Faculty of Veterinary Medicine, Free University of Berlin, Berlin, Germany
    J Vet Intern Med 22:1289-95. 2008
    Anaplasma phagocytophilum, the causative agent of canine granulocytic anaplasmosis (CGA), is a Gram-negative intracellular organism transmitted by ixodid ticks...

Research Grants78

  1. PROCESSING OF CHROMOGRANIN A BY THE FIBRINOLYTIC SYSTEM
    ROBERT PARMER; Fiscal Year: 2001
    ..project investigates novel interactions between the major secretory protein of catecholamine storage vesicles, chromogranin A (CgA), and the plasminogen/t-PA system, resulting in generation of active CgA peptide fragments which modulate ..
  2. CHROMOGRANIN A--NICOTINIC SIGNALING AND DESENSITIZATION
    Sushil Mahata; Fiscal Year: 2001
    b>Chromogranin A: nicotinic signaling and desensitization. Nicotine is a component of tobacco that motivates continued abuse despite harmful effects...
  3. STIMULUS/TRANSCRIPTION COUPLING IN SYMPATHOADRENAL CELLS
    DANIEL O CONNOR; Fiscal Year: 1999
    ..effects on re-synthesis convergent with (similar to) or divergent from that for its effects on secretion? Chromogranin A (CgA) is the major soluble protein in the core of catecholamine storage vesicles...
  4. SYNTHESIS OF DBH, CHROMOGRANINS AND CHROMAFFIN VESICLES
    NORMAN KIRSHNER; Fiscal Year: 1990
    ..are to obtain an understanding of the factors regulating the synthesis of dopamine- beta-hydroxylase (DBH) and chromogranin A (CgA) and their incorporation into chromaffin vesicles...
  5. Clinico-Genomic Assessment of Performance Status in Elderly AML Patients
    Arati V Rao; Fiscal Year: 2013
    ..with Acute Myeloid Leukemia (AML), and correlate them with clinical markers via Comprehensive Geriatric Assessment (CGA). Dr...
  6. Role of Chromogranin A in Metabolic Syndrome
    Sushil K Mahata; Fiscal Year: 2013
    ..We have identified that chromogranin A (Chga)-derived peptide, catestatin (CST), lowers blood pressure (BP) and heart rate (HR) by inhibiting release ..
  7. Role of Dicer in Gonadotrope and Reproductive Function
    T Rajendra Kumar; Fiscal Year: 2013
    ..The genes encoding the common alpha subunit (Cga) and the hormone-specific beta subunits (Lhb and Fshb) are coordinately regulated by hypothalamic gonadotropin-..
  8. Tanner J Freeman; Fiscal Year: 2015
    ..Using tissues from our murine models, differentiation (intestinal alkaline phosphatase, muc2, chromogranin A, lysozyme) and stem cell marker expression (Lgr5, Lrig1, Ascl2, Olfm4, DcamKL1, Mshi1) will be determined by ..
  9. Sucheta M Vaingankar; Fiscal Year: 2015
    ..of the diffuse neuroendocrine system have storage secretory granules that ubiquitously contain the pro-hormone Chromogranin A (CHGA)...
  10. Jonathan M Davis; Fiscal Year: 2016
    ..and adverse event monitoring and by Bayley neurodevelopmental assessments at 18 months corrected gestational age (CGA)...
  11. Luisa A DiPietro; Fiscal Year: 2015
    ..Recently we identified pigment epithelium-derived factor (PEDF) and vasostatin-1 (a fragment of chromogranin A) as anti-angiogenic factors that are produced in wounds and likely to play a role in the regulation of wound ..
  12. DARIO AA VIGNALI; Fiscal Year: 2014
    ..We will use a panel of TCRs specific for two primary autoantigens of considerable interest, insulin (Ins) and chromogranin A (ChgA), that possess a very broad range of insulitogenic and diabetogenic potentials, novel mouse models and ..
  13. Gene Expression of Neuroblastoma and Normal Cells in Bone Marrow Predicts Outcome
    ROBERT CHARLES SEEGER; Fiscal Year: 2012
    ..We anticipate that this assay will become an integral biomarker tool for evaluating response to new therapeutic strategies and for predicting outcome of children with high-risk neuroblastoma. ..
  14. KATHRYN M HASKINS; Fiscal Year: 2016
    ..This work has led to the recent discovery of a new autoantigen in T1D, the secretory granule protein, chromogranin A. The underlying hypothesis of this project is that the antigenic ligands for this panel of diabetogenic clones ..
  15. Thomas Delong; Fiscal Year: 2014
    ..of this project is to use proteomics to investigate a post-translational modification that is associated with Chromogranin A, the recently discovered autoantigen for the diabetogenic CD4 T cell clone BDC-2.5...
  16. Discovering the Genetic Basis of Hypertension
    Eleazar Eskin; Fiscal Year: 2010
    ..We demonstrate initial results over the Chromogranin A locus...
  17. Sucheta M Vaingankar; Fiscal Year: 2015
    DESCRIPTION (provided by applicant): Derangements in the CHGA (chromogranin A) pathway are associated with hypertensive renal disease, a devastating illness found principally in African Americans...
  18. Rescue of Chga knockout phenotype by CHGA-BAC transgene
    Sucheta Vaingankar; Fiscal Year: 2009
    b>Chromogranin A (CGA) is co-stored with catecholamines in chromaffin granules and co-released in response to sympathoadrenal stimulation...
  19. PROGNOSTIC FACTORS IN NON-SMALL CELL LUNG CANCER
    Stephen Graziano; Fiscal Year: 1991
    ..with advanced NSCLC showed that patients with neuroendocrine features (neuron-specific enolase, Leu-7 and chromogranin A) as measured by immunoperoxidase on paraffin-embedded tissue has an increased likelihood of response to ..
  20. AP4 Center for Studies on Hereditary Colorectal Cancer
    Bruce Boman; Fiscal Year: 2004
    ..organization of academic investigators - the Collaborative Group of the Americas for Inherited Colorectal Cancer (CGA-ICC). 3) Our team has an established track record of working with biotechnology and industry in cancer research...
  21. CHROMOGRANIN A IN EXPERIMENTAL HYPERTENSION
    MARWAN TAKIYYUDDIN; Fiscal Year: 1993
    b>Chromogranin A (CgA) is the major soluble protein stored in catecholamine storage vesicles in the adrenal medulla and sympathetic nerves. Its plasma concentration varies as a function of sympathoadrenal activation...
  22. MECHANISMS FOR SORTING OF CHROMOGRANIN A
    Sven Ulrik Gorr; Fiscal Year: 2000
    ..Chromagranin A (CgA) is co-stored with peptide hormones in secretory granules of most endocrine and neuroendocrine cells...
  23. STRIATAL ENERGETICS AND HUNTINGTON'S DISEASE
    JANET DUBINSKY; Fiscal Year: 2003
    ..The objective of the current proposal is to investigate the relationship between the expression of expanded CGA repeats and the bioenergetic defects associated with Huntington's disease and activation of the mitochondrial ..
  24. Chromaffin Cell physiology: Novel molecular approaches
    Sushil Mahata; Fiscal Year: 2009
    DESCRIPTION (provided by applicant): Chromogranin A (CHGA) is a 48 kDa acidic proprotein giving rise to biologically active peptides including a novel fragment (bovine CHGA344-364;human CHGA352-372) which we have discovered and called "..
  25. SALIVARY MUCOUS CELL GENE EXPRESSION
    DAVID CULP; Fiscal Year: 2007
    ..Interestingly, it has recently been determined that the major secretion product of neuroendocrine cells, chromogranin A, functions as a rate-limiting step in the biogenesis of secretory granules and regulated exocrine secretion...
  26. Sympathetic Outflow to Catecholamine Storage Vesicles
    DANIEL O CONNOR; Fiscal Year: 2006
    ..The chromogranins/secretogranins (chromogranin A [Cga]. Chromogranin B [Cgb]...
  27. Traffic of catecholamine storage vesicle proteins
    Laurent Taupenot; Fiscal Year: 2005
    ..pathway of hormone or neurotransmitter secretion has been documented, especially for its index member, chromogranin A (CgA)...
  28. Resistant E.coli in Humans and Poultry
    James Johnson; Fiscal Year: 2005
    ..Does the research address a current and compelling problem of antimicrobial resistance that is of high public health importance and for which research is needed? [yes]. ..
  29. Support of the Caregiver of the Older Cancer Patient Undergoing Chemotherapy
    Lodovico Balducci; Fiscal Year: 2008
    ..This study provides an opportunity to address problems associatedwith intense short-term caregiving in this expanding population. ..
  30. Regulating Neuroendocrine Phenotype in Cancer
    Herbert Chen; Fiscal Year: 2010
    ..Furthermore, these finding may permit development of components of raf-1 pathway as therapeutic targets in the treatment and palliation of NE tumors. ..
  31. Phase II Clinical Trial Utilizing Lithium for Patients with Neuroendocrine Tumors
    Herbert Chen; Fiscal Year: 2008
    ..Besides surgery, there are limited curative and palliative treatments available to patients with metastatic NE tumors, emphasizing the need for development of other forms of therapy. [unreadable] [unreadable] [unreadable]..
  32. Signaling Pathways in Medullary Thyroid Cancer
    Herbert Chen; Fiscal Year: 2004
    ..abstract_text> ..
  33. Novel Signaling Targets in GI Neuroendocrine Tumors
    Herbert Chen; Fiscal Year: 2005
    ..The possibility that raf-l-mediated hormone suppression could be induced by a soluble factor would provide a plausible, therapeutic delivery method. ..
  34. 31st NATIONAL MEDICINAL CHEMISTRY SYMPOSIUM
    Barry Gold; Fiscal Year: 2008
    ..NIH funds will be used to reimburse travel award recipients for the registration fee, campus lodging, awards banquet, and airfare. [unreadable] [unreadable] [unreadable] [unreadable]..
  35. Sequence Specific Triple Helix Forming Molecules
    Barry Gold; Fiscal Year: 2007
    ..abstract_text> ..
  36. RELATIONSHIP BETWEEN DNA STRUCTURE AND ADDUCT FORMATION
    Barry Gold; Fiscal Year: 2004
    ..abstract_text> ..
  37. DNA Damage: Roles in Toxicity and Mutagenicity
    Barry Gold; Fiscal Year: 2008
    ..The results of the above aims should provide useful information on the toxicity and tumorigenicity of 3-MeA and related DNA lesions, as well as how tumorigenicity can be avoided to afford improved and safer cancer chemotherapies. ..
  38. DNA Methylation as an Epigenetic Host Factor in HIV/AIDS
    Jianming Tang; Fiscal Year: 2006
    ..abstract_text> ..
  39. Molecular strategies to define carcinoids and rationalize surgical intervention
    Irvin Modlin; Fiscal Year: 2009
    ..In SICs and their metastases, the neuroendocrine marker chromogranin A (CgA);NAP1L1 (mitosis regulator);MAGE-D2 (liver metastatic predictor), and MTA1 (metastasis, migration), are ..
  40. Transplanted Stem Cells and Tumor Progression
    Melissa H Wong; Fiscal Year: 2010
    ..It is feasible that fusion promoting factors, or the fusion products themselves, may be useful targets for preventing tumor progression. ..
  41. Targeting the oligomerization of human ABCG2
    Jian Ting Zhang; Fiscal Year: 2009
    ..This work may also lead us to the discovery of a new class of therapeutic agents that can help overcome drug-resistant cancers. ..
  42. In vivo regulation of M. tuberculosis cell wall lipids
    Lee W Riley; Fiscal Year: 2010
    ..tuberculosis and granulomas may contribute to our understanding of the mechanism of persistence of M. tuberculosis that could lead to new tests to differentiate active TB from latent TB infection. ..
  43. Association of 7q22.1 gene VGF with obesity and leaness
    Stephen Salton; Fiscal Year: 2008
    ..These physiologically linked, target-tissue genes may themselves play a functional role in obesity resistance or susceptibility, and thus become excellent candidates for future investigation. ..
  44. Role of p170 in lung tumorigenesis
    Jian Ting Zhang; Fiscal Year: 2007
    ..This work will certainly add to our understanding of the functional mechanism of translation initiation of protein synthesis. ..
  45. MECHANISM OF DRUG BINDING TO P-GLYCOPROTEIN
    Jian Ting Zhang; Fiscal Year: 2001
    ..This work may lead us to the discovery of a new family of chaperone proteins associated with ribosomes that are important in determining the folding of membrane proteins co-translationally. ..
  46. MOLECULAR BASES OF MULTIDRUG RESISTANCE IN CANCERS
    Jian Ting Zhang; Fiscal Year: 2001
    ..Additionally, this study will increase our understanding of how specific protein topological structures are related to transport functions in general. ..
  47. CONTROL OF CELL GROWTH
    Jonathan Gallant; Fiscal Year: 2005
    ..Because starvation conditions and the occurrence of a hungry codon may be frequent in nature, these phenomena are important to an understanding of translation and its control. ..
  48. PITUITARY CELLS TO STUDY MALE INFERTILITY
    STEPHEN WINTERS; Fiscal Year: 2002
    ..abstract_text> ..
  49. MOLECULAR BIOLOGY OF INFECTION WITH M TUBERCULOSIS
    Lee Riley; Fiscal Year: 2002
    ..In addition, these studies may identify several potential targets for new chemotherapeutic agents or vaccine candidates. ..
  50. MOLECULAR BIOLOGY OF NOREPINEPHRINE BIOSYNTHESIS
    Esther Sabban; Fiscal Year: 2006
    ..These findings will contribute to the development of new strategies to prevent the harmful maladaptive changes in catecholamine neurotransmission, while enhancing its beneficial adaptive aspects ..
  51. b-catenin's role in establishing the gut stem cell niche
    Melissa Wong; Fiscal Year: 2009
    ..These proposed studies will directly examine the role of Wnt/beta-catenin signaling on maintenance of the stem cell niche and will shed insight into the regulatory control of intestinal stem cells. ..
  52. Epidemiology of an uropathogenic E coli clonal group
    Lee Riley; Fiscal Year: 2003
    ..characterize the epidemiology of a recently identified clonal group of uropathogenic Escherichia coli designated as CgA. CgA refers to a set of multidrug-resistant E...
  53. VGF: A NOVEL REGULATOR OF ENERGY BALANCE
    Stephen Salton; Fiscal Year: 2004
    ....
  54. Therapeutic vaccine against tuberculosis
    Lee Riley; Fiscal Year: 2006
    ..Therapeutic vaccines against TB is a major priority in TB control, and we have an opportunity to identify such products by a novel approach using a simple, inexpensive, and reproducible animal model. ..
  55. Genetic Epidemiology of Adult Brain Cancer: A Follow-up Study
    Jianming Tang; Fiscal Year: 2008
    ..abstract_text> ..
  56. Sympathetic Ganglia: New Target for ACTH with Stress
    Esther Sabban; Fiscal Year: 2008
    ..abstract_text> ..
  57. Mechanisms of neuronal hypoglycemic injury
    Stephen Salton; Fiscal Year: 2005
    ..In addition, we propose to identify genes that are regulated in the embryonic and early post-natal hippocampus by hypoglycemia, which we hope will offer insight into the mechanism(s) by which the hippocampus is damaged. ..
  58. Molecular Strategies for Gastric Carcinoid Surgery
    Irvin Modlin; Fiscal Year: 2005
    ..A pre-operative determination of the neoplastic ECL cell gene expression relating to gastrin responsiveness will improve the rationale for therapeutic gastric or antral resection. ..
  59. Pancreatic zymogen activation in a reconstituted system
    Edwin Thrower; Fiscal Year: 2006
    ..We plan to use this system to identify the compartment(s) responsible for zymogen processing and to examine the ATP and calcium-dependent mechanism of activation. [unreadable] [unreadable] [unreadable]..
  60. In search of the intestinal stem cell
    Melissa Wong; Fiscal Year: 2004
    ..These studies will determine if a signaling cascade is responsible for defining "stemness" or if a yet to be defined master regulator molecule directs synergy of the multiple pathways. ..
  61. The International Symposium on Regulatory Peptides
    JUAN ROZENGURT; Fiscal Year: 2008
    ..unreadable] [unreadable] [unreadable]..
  62. ANTIOXIDANT GENES OF MYCOBACERIUM TUBERCULOSIS
    Lee Riley; Fiscal Year: 2001
    ....
  63. REGULATION OF VGF BY NEUROTROPHIC GROWTH FACTORS
    Stephen Salton; Fiscal Year: 2001
    ..The proposed studies will clarify how neurotrophic factors and gene products they regulate support neuronal development and regeneration in the aging and injured nervous system. ..
  64. Orgin of multidrug resistant uropathogenic E. coli
    Lee Riley; Fiscal Year: 2008
    ..coil belonging to a single clonal group called CgA were responsible for 50% of drug-resistant UTI among women in a college campus...
  65. Phenotypic Plasticity in Human Neuroblastoma
    Robert Ross; Fiscal Year: 2008
    ..abstract_text> ..
  66. Biochemical System for Study of DNA Repair
    Weiguo Cao; Fiscal Year: 2003
    ..Insights gained from this study will provide a biochemical framework for investigation of human endonuclease V-mediated repair pathway. ..
  67. Effector Function of Autoreactive Th1 T Cells
    KATHRYN M HASKINS; Fiscal Year: 2010
    ..A more complete understanding of the effector function of Th1 T cell subsets will help us design more specific approaches to T cell targeted immunotherapy. ..
  68. Pancreastatin: Studies in Human Physiology and Disease
    Peter Cadman; Fiscal Year: 2003
    ..A growing body of evidence suggests that the catecholamine vesicle protein chromogranin A (or CgA) functions as a pro-hormone and is proteolytically cleaved into a dysglycemic peptide, named ..
  69. GI PEPTIDE SIGNALING THROUGH TYROSINE PHOSPHORYLATION
    JUAN ENRIQUE ROZENGURT; Fiscal Year: 2010
    ....