CD40 ligand

Summary

Gene Symbol: CD40 ligand
Description: CD40 ligand
Alias: CD154, CD40L, HIGM1, IGM, IMD3, T-BAM, TNFSF5, TRAP, gp39, hCD40L, CD40 ligand, CD40 antigen ligand, CD40-L, T-B cell-activating molecule, T-cell antigen Gp39, TNF-related activation protein, tumor necrosis factor (ligand) superfamily member 5
Species: human
Products:     CD40 ligand

Top Publications

  1. Henn V, Slupsky J, Grafe M, Anagnostopoulos I, Forster R, Müller Berghaus G, et al. CD40 ligand on activated platelets triggers an inflammatory reaction of endothelial cells. Nature. 1998;391:591-4 pubmed
    b>CD40 ligand (CD40L, CD154), a transmembrane protein structurally related to the cytokine TNF-alpha, was originally identified on stimulated CD4+ T cells, and later on stimulated mast cells and basophils...
  2. Sui Z, Sniderhan L, Schifitto G, Phipps R, Gelbard H, Dewhurst S, et al. Functional synergy between CD40 ligand and HIV-1 Tat contributes to inflammation: implications in HIV type 1 dementia. J Immunol. 2007;178:3226-36 pubmed
    ..To investigate the inflammatory aspects of the disease, we examined the levels of soluble CD40L (sCD40L) in paired samples of plasma and cerebrospinal fluid obtained from 25 HIV-infected individuals...
  3. Garlichs C, Kozina S, Fateh Moghadam S, Handschu R, Tomandl B, Stumpf C, et al. Upregulation of CD40-CD40 ligand (CD154) in patients with acute cerebral ischemia. Stroke. 2003;34:1412-8 pubmed
    ..Seventeen patients with TIA, 60 patients with complete stroke, and 15 control subjects were investigated. CD154 and P-selectin were analyzed on platelets and CD40 on monocytes during and 3 months after acute cerebral ischemia ..
  4. Missiou A, Wolf D, Platzer I, Ernst S, Walter C, Rudolf P, et al. CD40L induces inflammation and adipogenesis in adipose cells--a potential link between metabolic and cardiovascular disease. Thromb Haemost. 2010;103:788-96 pubmed publisher
    b>CD40L figures prominently in atherogenesis. Recent data demonstrate elevated levels of sCD40L in the serum of patients with the metabolic syndrome (MS)...
  5. Xia M, Li G, Ma J, Ling W. Phosphoinositide 3-kinase mediates CD40 ligand-induced oxidative stress and endothelial dysfunction via Rac1 and NADPH oxidase 2. J Thromb Haemost. 2010;8:397-406 pubmed publisher
    b>CD40 ligand (CD40L) has been implicated as an inducer of reactive oxygen species (ROS) generation in endothelial cells, but definitive evidence for this and the in vivo relevance haves not been demonstrated fully...
  6. Burdon K, Langefeld C, Beck S, Wagenknecht L, Carr J, Rich S, et al. Variants of the CD40 gene but not of the CD40L gene are associated with coronary artery calcification in the Diabetes Heart Study (DHS). Am Heart J. 2006;151:706-11 pubmed
    CD40/CD40L signaling is known to play an important role in immune response. The proteins are expressed in a variety of cell types and ligation causes cells to produce inflammatory cytokines and cellular adhesion molecules...
  7. Xu H, Zhang X, Mannon R, Kirk A. Platelet-derived or soluble CD154 induces vascularized allograft rejection independent of cell-bound CD154. J Clin Invest. 2006;116:769-74 pubmed
    b>CD154 is a cell surface molecule expressed on activated T cells that binds to CD40, an activating molecule on APCs...
  8. Roselli M, Mineo T, Basili S, Martini F, Mariotti S, Aloe S, et al. Soluble CD40 ligand plasma levels in lung cancer. Clin Cancer Res. 2004;10:610-4 pubmed
    Tumor-induced platelet activation may cause the release of various cytokines, including CD40 ligand (CD40L)...
  9. Amirkhosravi A, Amaya M, Desai H, Francis J. Platelet-CD40 ligand interaction with melanoma cell and monocyte CD40 enhances cellular procoagulant activity. Blood Coagul Fibrinolysis. 2002;13:505-12 pubmed
    ..Activated platelets express and release CD40 ligand (CD40L), which induces endothelial TF expression by ligation to CD40...

More Information

Publications86

  1. Grassme H, Bock J, Kun J, Gulbins E. Clustering of CD40 ligand is required to form a functional contact with CD40. J Biol Chem. 2002;277:30289-99 pubmed
    ..We show that clustering of the CD40 receptor depends on reciprocal clustering of the CD40 ligand (gp39, CD154)...
  2. Sipsas N, Sfikakis P, Kontos A, Kordossis T. Levels of soluble CD40 ligand (CD154) in serum are increased in human immunodeficiency virus type 1-infected patients and correlate with CD4(+) T-cell counts. Clin Diagn Lab Immunol. 2002;9:558-61 pubmed
    b>CD40 ligand (CD40L or CD154) is a costimulatory molecule expressed mainly on activated CD4(+) T cells...
  3. Challa A, Eliopoulos A, Holder M, Burguete A, Pound J, Chamba A, et al. Population depletion activates autonomous CD154-dependent survival in biopsylike Burkitt lymphoma cells. Blood. 2002;99:3411-8 pubmed
    ..Below a normally suicidal threshold number of cells, low picomolar quantities of exogenous CD40 ligand (CD40L/CD154) were found to sustain the clone without the discernible shift in phenotype that accompanies high ..
  4. Andre P, Prasad K, Denis C, He M, Papalia J, Hynes R, et al. CD40L stabilizes arterial thrombi by a beta3 integrin--dependent mechanism. Nat Med. 2002;8:247-52 pubmed
    b>CD40L, a member of the tumor necrosis factor family of ligands, plays a major role in immune responses via its receptor, CD40. Recently, CD40L has been detected on the surfaces of activated platelets and shown to activate endothelium...
  5. Aruffo A, Farrington M, Hollenbaugh D, Li X, Milatovich A, Nonoyama S, et al. The CD40 ligand, gp39, is defective in activated T cells from patients with X-linked hyper-IgM syndrome. Cell. 1993;72:291-300 pubmed
    The prominent role of the CD40 receptor in B cell responses led us to investigate the role of the gp39-CD40 interaction in a group of primary immunodeficient patients with defective antibody production...
  6. Spriggs M, Armitage R, Strockbine L, Clifford K, Macduff B, Sato T, et al. Recombinant human CD40 ligand stimulates B cell proliferation and immunoglobulin E secretion. J Exp Med. 1992;176:1543-50 pubmed
    ..A comparison of the efficacy of the hCD40-L and mCD40-L in these assays is presented. ..
  7. Dai Y, Masterman T, Huang W, Hillert J. Analysis of a CD40 ligand dinucleotide microsatellite in multiple sclerosis. Eur J Immunogenet. 2002;29:81-5 pubmed
    In recent years, numerous reports have described the diverse roles of the CD40-CD40 ligand receptor-ligand pair. The interaction of these two cell-surface molecules regulates both humoral and cell-mediated immune functions...
  8. Ueno T, Watanabe H, Fukuda N, Tsunemi A, Tahira K, Matsumoto T, et al. Influence of genetic polymorphisms in oxidative stress related genes and smoking on plasma MDA-LDL, soluble CD40 ligand, E-selectin and soluble ICAM1 levels in patients with coronary artery disease. Med Sci Monit. 2009;15:CR341-8 pubmed
    ..of the NADH/NADPH oxidase, and glutathione-S-transferase T1, M1 and P1 polymorphisms on plasma MDA-LDL, soluble CD40 ligand, E-selectin and soluble ICAM1 levels was determined...
  9. Yuan M, Ohishi M, Wang L, Raguki H, Wang H, Tao L, et al. Association between serum levels of soluble CD40/CD40 ligand and organ damage in hypertensive patients. Clin Exp Pharmacol Physiol. 2010;37:848-51 pubmed publisher
    1. CD40 and CD40 ligand (CD40L) have a critical role in the pathophysiology and risk prediction of coronary artery syndrome, including atherothrombosis and atherosclerosis...
  10. Martin Donaire T, Losada Fernandez I, Perez Chacon G, Rua Figueroa I, Erausquin C, Naranjo Hernandez A, et al. Association of the microsatellite in the 3' untranslated region of the CD154 gene with rheumatoid arthritis in females from a Spanish cohort: a case-control study. Arthritis Res Ther. 2007;9:R89 pubmed
    CD40-CD154 interaction is an important mediator of inflammation and has been implicated in T helper type 1-mediated autoimmune diseases including rheumatoid arthritis (RA)...
  11. Yacoub D, Hachem A, Théorêt J, Gillis M, Mourad W, Merhi Y. Enhanced levels of soluble CD40 ligand exacerbate platelet aggregation and thrombus formation through a CD40-dependent tumor necrosis factor receptor-associated factor-2/Rac1/p38 mitogen-activated protein kinase signaling pathway. Arterioscler Thromb Vasc Biol. 2010;30:2424-33 pubmed publisher
    b>CD40 ligand is a thromboinflammatory molecule that predicts cardiovascular events...
  12. Korthauer U, Graf D, Mages H, Briere F, Padayachee M, Malcolm S, et al. Defective expression of T-cell CD40 ligand causes X-linked immunodeficiency with hyper-IgM. Nature. 1993;361:539-41 pubmed
    X chromosome-linked immunodeficiency with hyper-IgM (HIGM1, MIM number 308230) is a rare disorder characterized by recurrent bacterial infections, very low or absent IgG, IgA and IgE, and normal to increased IgM and IgD serum levels...
  13. Romano M, Buffolano W, Bisogni R, Russo R, Liuzzi R, Bunders M, et al. Increased CD154 expression in uninfected infants born to HIV-positive mothers exposed to antiretroviral prophylaxis. Viral Immunol. 2006;19:363-72 pubmed
    ..In particular, treatment with nucleoside analogs was found to increase CD40 ligand (CD40L; CD154) levels, an inducible molecule expressed on activated T lymphocytes...
  14. Damås J, Jensenius M, Ueland T, Otterdal K, Yndestad A, Frøland S, et al. Increased levels of soluble CD40L in African tick bite fever: possible involvement of TLRs in the pathogenic interaction between Rickettsia africae, endothelial cells, and platelets. J Immunol. 2006;177:2699-706 pubmed
    ..1) Patients with ATBF (n = 15) had increased serum levels of soluble CD40 ligand (sCD40L), which decreased during follow-up...
  15. Nadiri A, Polyak M, Jundi M, Alturaihi H, Reyes Moreno C, Hassan G, et al. CD40 translocation to lipid rafts: signaling requirements and downstream biological events. Eur J Immunol. 2011;41:2358-67 pubmed publisher
    ..Its interaction with its ligand, CD154, plays a pivotal role in humoral and cell-mediated immunity...
  16. Blotta M, Marshall J, DeKruyff R, Umetsu D. Cross-linking of the CD40 ligand on human CD4+ T lymphocytes generates a costimulatory signal that up-regulates IL-4 synthesis. J Immunol. 1996;156:3133-40 pubmed
    ..synthesis, using immobilized mAbs against several T cell surface molecules, including CD3, CD28, and the CD40 ligand (CD40L)...
  17. Sabeti P, Usen S, Farhadian S, Jallow M, Doherty T, Newport M, et al. CD40L association with protection from severe malaria. Genes Immun. 2002;3:286-91 pubmed
    b>CD40 ligand (CD40L), a glycoprotein involved in B cell proliferation, antigen presenting cell activation, and Ig class switching, is important in the immune response to infection...
  18. Schubert L, Cron R, Cleary A, Brunner M, Song A, Lu L, et al. A T cell-specific enhancer of the human CD40 ligand gene. J Biol Chem. 2002;277:7386-95 pubmed
    We observed that the human CD40 ligand (CD40L) gene 5'-flanking region conferred weak promoter activity in activated CD4 T cells, suggesting that additional regions are required for optimal CD40L gene transcription...
  19. Bavendiek U, Libby P, Kilbride M, Reynolds R, Mackman N, Schonbeck U. Induction of tissue factor expression in human endothelial cells by CD40 ligand is mediated via activator protein 1, nuclear factor kappa B, and Egr-1. J Biol Chem. 2002;277:25032-9 pubmed
    ..However, the molecular mechanisms of tissue factor gene expression triggered by CD40 ligand (CD40L) in this cell type remain unknown...
  20. Chavez Rueda K, Legorreta Haquet M, Cervera Castillo H, Sanchez L, Jara L, Zenteno E, et al. Prolactin effect on CD69 and CD154 expression by CD4+ cells from systemic lupus erythematosus patients. Clin Exp Rheumatol. 2005;23:769-77 pubmed
    ..with: a) medium alone as a negative control, b) unspecific mitogen as a positive control (PMA-ionomycin for CD154 or concanavalin A for CD69), c) PRL alone, d) mitogen plus PRL, e) mitogen plus antibody anti-PRL (1:50) and f) ..
  21. Huang J, Jochems C, Talaie T, Anderson A, Jales A, Tsang K, et al. Elevated serum soluble CD40 ligand in cancer patients may play an immunosuppressive role. Blood. 2012;120:3030-8 pubmed publisher
    ..In this study, we showed that an extracellular portion of a membrane-bound ligand of CD40 (soluble CD40 ligand; sCD40L) was significantly elevated in the serum of cancer patients compared with healthy donors...
  22. Mikolajczak S, Ma B, Yoshida T, Yoshida R, Kelvin D, Ochi A. The modulation of CD40 ligand signaling by transmembrane CD28 splice variant in human T cells. J Exp Med. 2004;199:1025-31 pubmed
    The role of CD40 ligand (CD40L)/CD40 signaling in T cell-dependent B cell differentiation and maturation has been amply documented...
  23. Citores M, Rua Figueroa I, Rodriguez Gallego C, Durantez A, Garcia Laorden M, Rodriguez Lozano C, et al. The dinucleotide repeat polymorphism in the 3'UTR of the CD154 gene has a functional role on protein expression and is associated with systemic lupus erythematosus. Ann Rheum Dis. 2004;63:310-7 pubmed
    To investigate the association of the (CA)n dinucleotide repeat in the 3' untranslated region (3'UTR) of the CD154 gene with systemic lupus erythematosus (SLE), and its functional role in protein expression...
  24. Zirlik A, Maier C, Gerdes N, MacFarlane L, Soosairajah J, Bavendiek U, et al. CD40 ligand mediates inflammation independently of CD40 by interaction with Mac-1. Circulation. 2007;115:1571-80 pubmed
    Strong evidence supports a role for CD40 ligand (CD40L) as marker and mediator of inflammatory diseases such as atherosclerosis...
  25. Hamilton B, Genin A, Cron R, Rigby W. Delineation of a novel pathway that regulates CD154 (CD40 ligand) expression. Mol Cell Biol. 2003;23:510-25 pubmed
    The expression of CD154 (CD40 ligand) by activated T lymphocytes plays a central role in humoral and cellular immunity...
  26. van Kooten C, Banchereau J. CD40-CD40 ligand. J Leukoc Biol. 2000;67:2-17 pubmed
    ..In addition, the CD40-ligand (CD40-L/CD154), a member of the TNF family, is also expressed more widely than activated CD4+ T cells only...
  27. Hermann A, Rauch B, Braun M, Schror K, Weber A. Platelet CD40 ligand (CD40L)--subcellular localization, regulation of expression, and inhibition by clopidogrel. Platelets. 2001;12:74-82 pubmed
    ..localization and the regulation of expression of the platelet activation markers CD62P and CD63 with CD40 ligand (CD40L) on the surface of washed human platelets...
  28. El Fakhry Y, Alturaihi H, Diallo D, Merhi Y, Mourad W. Critical role of lipid rafts in CD154-mediated T cell signaling. Eur J Immunol. 2010;40:770-9 pubmed publisher
    Although signal pathways triggered via the CD40 molecule are well characterized, those induced via CD154 are less known. This study demonstrates that engagement of CD154 in Jurkat D1...
  29. Kyle R, Larson D, Therneau T, Dispenzieri A, Kumar S, Cerhan J, et al. Long-Term Follow-up of Monoclonal Gammopathy of Undetermined Significance. N Engl J Med. 2018;378:241-249 pubmed publisher
    ..Among patients with IgM MGUS, the presence of two adverse risk factors - namely, an abnormal serum free light-chain ratio (ratio of kappa ..
  30. Ronca R, Tamma R, Coltrini D, Ruggieri S, Presta M, Ribatti D. Fibroblast growth factor modulates mast cell recruitment in a murine model of prostate cancer. Oncotarget. 2017;8:82583-82592 pubmed publisher
    ..Accordingly, the FGF antagonist long pentraxin-3 (PTX3) and the PTX3-derived small molecule FGF-trap NSC12 have been shown to inhibit the growth and vascularization of different FGF-dependent tumor types, including ..
  31. Sim J, Kim H, Chang S, Kim I, Lipsky P, Lee J. Autoregulatory function of interleukin-10-producing pre-naïve B cells is defective in systemic lupus erythematosus. Arthritis Res Ther. 2015;17:190 pubmed publisher
    ..Autoreactivity of antibodies produced by pre-naïve B cells was tested by measuring immunoglobulin M (IgM) autoantibodies in culture supernatants after differentiation...
  32. Karnan S, Ota A, Konishi Y, Wahiduzzaman M, Hosokawa Y, Konishi H. Improved methods of AAV-mediated gene targeting for human cell lines using ribosome-skipping 2A peptide. Nucleic Acids Res. 2016;44:e54 pubmed publisher
    ..this study, we sought to improve the efficiency of AAV-mediated gene targeting by introducing a 2A-based promoter-trap system into targeting constructs...
  33. Bargieri D, Thiberge S, Tay C, Carey A, Rantz A, Hischen F, et al. Plasmodium Merozoite TRAP Family Protein Is Essential for Vacuole Membrane Disruption and Gamete Egress from Erythrocytes. Cell Host Microbe. 2016;20:618-630 pubmed publisher
    Surface-associated TRAP (thrombospondin-related anonymous protein) family proteins are conserved across the phylum of apicomplexan parasites...
  34. Chen F, Wang Y, Yuan Y, Zhang W, Ren Z, Jin Y, et al. Generation of B cell-deficient pigs by highly efficient CRISPR/Cas9-mediated gene targeting. J Genet Genomics. 2015;42:437-44 pubmed publisher
    ..interspaced short palindromic repeat (CRISPR)/CRISPR-associated (Cas) system to target the JH region of the pig IgM heavy chain gene which is crucial for B cell development and differentiation...
  35. Rajagopal V, Marler J, Kokish M, Odom B. Trapped ion chain thermometry and mass spectrometry through imaging. Eur J Mass Spectrom (Chichester). 2016;22:1-7 pubmed publisher
    ..in a one-dimensional Coulomb crystal by relating their imaged spatial extent along the linear radiofrequency ion trap axis to normal modes of vibration of coupled oscillators in a harmonic potential...
  36. Ochaba J, Morozko E, O Rourke J, Thompson L. Fractionation for Resolution of Soluble and Insoluble Huntingtin Species. J Vis Exp. 2018;: pubmed publisher
    ..of various forms of mHTT-containing aggregates include fluorescence microscopy, western blot analysis, and filter trap assays...
  37. Saeidi Asl M, Adel M, Caipang C, Dawood M. Immunological responses and disease resistance of rainbow trout (Oncorhynchus mykiss) juveniles following dietary administration of stinging nettle (Urtica dioica). Fish Shellfish Immunol. 2017;71:230-238 pubmed publisher
    ..05). Additionally, several immune parameters, namely, IgM, lysozyme, complement components C3 and C4, and respiratory burst of blood leukocytes significantly increased in ..
  38. Bhat N, Adams C, Chen Y, Bieber M, Teng N. Identification of Cell Surface Straight Chain Poly-N-Acetyl-Lactosamine Bearing Protein Ligands for VH4-34-Encoded Natural IgM Antibodies. J Immunol. 2015;195:5178-88 pubmed publisher
    B cell binding and cytotoxicity by human VH4-34-encoded Abs of the IgM isotype has been well documented. A VH4-34-IgM has recently shown a favorable early response in a phase 1 trial for treatment of B cell acute lymphoblastic leukemia...
  39. Loubaki L, Semlali A, Boisvert M, Jacques E, Plante S, Aoudjit F, et al. Crosstalk between T cells and bronchial fibroblasts obtained from asthmatic subjects involves CD40L/alpha 5 beta 1 interaction. Mol Immunol. 2010;47:2112-8 pubmed publisher
    ..IL-6 mRNA and protein levels were measured by real time PCR and ELISA. CD40, CD40L and alpha 5 beta 1 were evaluated by flow cytometry. Bronchial fibroblasts were stimulated with rsCD40L...
  40. King A, Li L, Wong D, Liu R, Bamford R, Strasser A, et al. Dynein light chain regulates adaptive and innate B cell development by distinctive genetic mechanisms. PLoS Genet. 2017;13:e1007010 pubmed publisher
    ..Defects in B cell development caused by loss of DYNLL1 could also be partially suppressed by a pre-arranged SWHEL Igm-B cell receptor transgene...
  41. Van der Spek A, Bloise F, Tigchelaar W, Dentice M, Salvatore D, van der Wel N, et al. The Thyroid Hormone Inactivating Enzyme Type 3 Deiodinase is Present in Bactericidal Granules and the Cytoplasm of Human Neutrophils. Endocrinology. 2016;157:3293-305 pubmed publisher
    ..D3 is observed intracellularly during neutrophil extracellular trap formation, followed by a reduction of D3 staining after release of the neutrophil extracellular traps into the ..
  42. Wollman A, Syeda A, McGlynn P, Leake M. Single-Molecule Observation of DNA Replication Repair Pathways in E. coli. Adv Exp Med Biol. 2016;915:5-16 pubmed publisher
    The method of action of many antibiotics is to interfere with DNA replication-quinolones trap DNA gyrase and topoisomerase proteins onto DNA while metronidazole causes single- and double-stranded breaks in DNA...
  43. Rottloff S, Miguel S, Biteau F, Nisse E, Hammann P, Kuhn L, et al. Proteome analysis of digestive fluids in Nepenthes pitchers. Ann Bot. 2016;117:479-95 pubmed publisher
    ..For the genus Nepenthes, this strategy represents producing pitcher-modified leaves that can trap and digest various prey...
  44. Abo Al Ela H, el Nahas A, Mahmoud S, Ibrahim E. Vitamin C Modulates the Immunotoxic Effect of 17?-Methyltestosterone in Nile Tilapia. Biochemistry. 2017;56:2042-2050 pubmed publisher
    ..interleukin 8 (il8), tumor necrosis factor ? (tnf?), CC-chemokine, Toll-like receptor 7 (tlr7), immunoglobulin M (IgM) heavy chain, and cellular apoptosis susceptibility (cas) induced by MT, excluding tnf? in the liver and CC-..
  45. Roh K, Song H, Pradhan P, Bai K, Bohannon C, Dale G, et al. A synthetic stroma-free germinal center niche for efficient generation of humoral immunity ex vivo. Biomaterials. 2018;164:106-120 pubmed publisher
    ..using biomaterial-based artificial "follicular T helper cells (TFH)" that provided both natural CD40-CD40L ligation as well as crosslinking of CD40 and by mimicking artificial "follicular dendritic cells (FDC)" to provide ..
  46. Wang Z, Liu N, Zhou G, Shi T, Wang Z, Gan J, et al. Expression of XBP1s in fibroblasts is critical for TiAl6 V4 particle-induced RANKL expression and osteolysis. J Orthop Res. 2017;35:752-759 pubmed publisher
    ..The effect of XBP1s on osteoclasts formation was determined by tartrate-resistant acid phosphatase (TRAP) staining in vitro osteoclastogenesis assay and in animal models...
  47. Simões K, Silva S, Machado E, Brasileiro H. Development of TRAP primers for Ricinus communis L. Genet Mol Res. 2017;16: pubmed publisher
    The objective of this article was to develop TRAP (target region amplification polymorphism) primers for castor bean, with the goal of making functional markers available for genetic studies about the species...
  48. Palmeirim A, Benchimol M, Vieira M, Peres C. Small mammal responses to Amazonian forest islands are modulated by their forest dependence. Oecologia. 2018;187:191-204 pubmed publisher
    ..Based on 65,520 trap-nights, we recorded 884 individuals of at least 22 small mammal species...
  49. Murray J, Mosteller J, Loberg J, Andersson M, Benka V. Methods of fertility control in cats: Owner, breeder and veterinarian behavior and attitudes. J Feline Med Surg. 2015;17:790-9 pubmed publisher
    ..Published estimates range from 27-93% for owned cats and 2-5% for cats trapped as part of a trap-neuter-return (TNR) program. In some regions and populations of cats, non-surgical fertility control is also used...
  50. Chen H, Zhong J, Yi Z, Zha J, Chen Y, Cai L. [Immunological mechanism of prednisone in the treatment of infantile spasm]. Zhongguo Dang Dai Er Ke Za Zhi. 2017;19:1044-1050 pubmed
    ..Immunoturbidimetric assay was used to measure serum levels of immunoglobulin A (IgA), immunoglobulin M (IgM), and immunoglobulin G (IgG)...
  51. Zhao S, Niu F, Xu C, Liu Y, Ye L, Bi G, et al. Diosgenin prevents bone loss on retinoic acid-induced osteoporosis in rats. Ir J Med Sci. 2016;185:581-7 pubmed publisher
    ..order to detect the biochemical index in different treatment groups, the serum tartrate-resistant acid phosphatase (TRAP), alkaline phosphatase (ALP), estradiol, and osteocalcin were compared among different groups...
  52. Mima Y, Abu Lila A, Shimizu T, Ukawa M, Ando H, Kurata Y, et al. Ganglioside inserted into PEGylated liposome attenuates anti-PEG immunity. J Control Release. 2017;250:20-26 pubmed publisher
    ..Immunogenicity of PEG, manifested by the robust production of anti-PEG IgM, is known to compromise the therapeutic efficacy and/or reduce the tolerance of PEGylated therapeutics...
  53. Padayachee M, Feighery C, Finn A, McKeown C, Levinsky R, Kinnon C, et al. Mapping of the X-linked form of hyper-IgM syndrome (HIGM1) to Xq26 by close linkage to HPRT. Genomics. 1992;14:551-3 pubmed
  54. Burn S, Washkowitz A, Gavrilov S, Papaioannou V. Postimplantation Mga expression and embryonic lethality of two gene-trap alleles. Gene Expr Patterns. 2018;27:31-35 pubmed publisher
    ..is necessary for the survival of the pluripotent epiblast cells of the peri-implantation embryo and a null, gene-trap allele MgaGt results in embryonic lethality shortly after implantation...
  55. Khunweeraphong N, Stockner T, Kuchler K. The structure of the human ABC transporter ABCG2 reveals a novel mechanism for drug extrusion. Sci Rep. 2017;7:13767 pubmed publisher
    ..elements of the architecture building the transmission interface that borders a central cavity which acts as a drug trap. The transmission interface is stabilized by salt-bridge interactions between the elbow helix and ICL1, as well as ..
  56. Sadek A, Hassan M, Esmat E, Eissa H. A new approach to the analysis of thermoluminescence glow-curve of TLD-600 dosimeters following Am-241 alpha particles irradiation. Radiat Prot Dosimetry. 2017;:1-12 pubmed publisher
    ..TLD-600) following alpha particles irradiation has been presented using general expressions derived from the one-trap-one recombination (OTOR)-level model...
  57. Chen X, Liang Z, Li D, Xiong Y, Xiong P, Guan Y, et al. Microfluidic dielectrophoresis device for trapping, counting and detecting Shewanella oneidensis at the cell level. Biosens Bioelectron. 2018;99:416-423 pubmed publisher
    ..However, to obtain more information regarding this species, it is essential to develop an approach to trap and detect S. oneidensis at the cell level...
  58. Angelico F, Alessandri C, Ferro D, Pignatelli P, Del Ben M, Fiorello S, et al. Enhanced soluble CD40L in patients with the metabolic syndrome: Relationship with in vivo thrombin generation. Diabetologia. 2006;49:1169-74 pubmed
    ..This study was designed to assess the behaviour of soluble CD40 ligand (sCD40L) and prothrombin fragment F (1+2), a marker of thrombin generation, in patients with the metabolic ..
  59. Ravanbakhsh M, Sarafnejad A, Aghamohammadi A, Kardar G, Asgarian Omran H, Atarod L, et al. CD40 ligand expression on stimulated T-helper lymphocytes in patients with common variable immunodeficiency. Iran J Allergy Asthma Immunol. 2007;6:129-35 pubmed
    ..In this study, we evaluated CD40 ligand expression on stimulated versus unstimulated T-helper lymphocytes of nine Common variable immunodeficient ..
  60. Pal R, Mani V, Tripathi D, Kumar R, Kewalramani N. Influence of Feeding Inorganic Vanadium on Growth Performance, Endocrine Variables and Biomarkers of Bone Health in Crossbred Calves. Biol Trace Elem Res. 2018;182:248-256 pubmed publisher
    ..Plasma hydroxyproline (Hyp) and tartrate-resistant acid phosphatase (TRAP) concentration were unchanged by V supplementation...
  61. Wu X, Huang Z, Wang X, Fu Z, Liu J, Huang Z, et al. Ketogenic Diet Compromises Both Cancellous and Cortical Bone Mass in Mice. Calcif Tissue Int. 2017;101:412-421 pubmed publisher
    ..Osteoblast and osteoclast expression of femur were identified using tartrate-resistant acid phosphatase (TRAP), collagen type I (CoLI), and osteocalcin (OCN) staining...
  62. Morvan F, Rondeau J, Zou C, Minetti G, Scheufler C, Scharenberg M, et al. Blockade of activin type II receptors with a dual anti-ActRIIA/IIB antibody is critical to promote maximal skeletal muscle hypertrophy. Proc Natl Acad Sci U S A. 2017;114:12448-12453 pubmed publisher
    ..Use of a soluble ActRIIB-Fc "trap," to block myostatin pathway signaling in normal or cachectic mice leads to hypertrophy or prevention of muscle ..
  63. Villa A, Notarangelo L, Di Santo J, Macchi P, Strina D, Frattini A, et al. Organization of the human CD40L gene: implications for molecular defects in X chromosome-linked hyper-IgM syndrome and prenatal diagnosis. Proc Natl Acad Sci U S A. 1994;91:2110-4 pubmed
    Recently, CD40L has been identified as the gene responsible for X chromosome-linked hyper-IgM syndrome (HIGM1)...
  64. Filozof C, Gomez Garre D, Reinares L, González Rubio M, Muñoz Pacheco P, Rueda A, et al. Relationship between plasma levels of soluble CD40L and insulin sensitivity and insulin secretion status in non-diabetic dyslipidemic patients. Diabetes Res Clin Pract. 2008;79:48-55 pubmed
    We have measured circulating plasma sCD40L as well as the platelet-surface of CD40L and its receptor in a sample of non-diabetic dyslipidemic patients and then evaluated its relationship with the insulin resistance (IR) and insulin ..
  65. Lau T, LeBlanc R, Botch Jones S. Stability of Synthetic Piperazines in Human Whole Blood. J Anal Toxicol. 2018;42:88-98 pubmed publisher
    ..were assessed on their degrees of degradation using a Shimadzu Ultra-Fast Liquid Chromatograph with SCIEX 4000 Q-Trap Electrospray Ionization Tandem Mass Spectrometer (UFLC-ESI-MS/MS) in positive ionization mode...
  66. Lin H, Mei X, Hong Y, Zhao Y, Guo X, Yang D, et al. Sequence analysis of the thrombospondin-related adhesive protein gene and heat shock protein 70 gene of Babesia gibsoni isolated from dogs in Nanjing, China. Infect Genet Evol. 2017;56:111-116 pubmed publisher
    In this study, the thrombospondin-related adhesive protein (TRAP) gene and the heat shock protein 70 (Hsp70) gene of Babesia gibsoni isolated from the naturally infected dog in the Nanjing area were cloned and sequenced...
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    Post-stroke epilepsy (PSE) has a negative effect on stroke prognosis and quality of life. The CD40/CD40L system is reported to be involved in the progression of multiple disease states...
  68. Switalski A, Bateman H. Anthropogenic water sources and the effects on Sonoran Desert small mammal communities. Peerj. 2017;5:e4003 pubmed publisher
    ..A total of 370 individual mammals representing three genera and eight species were captured in 4,800 trap nights from winter 2011 to spring 2012...
  69. Wei L, Wang Q, Zhang Y, Yang C, Guan H, Chen Y, et al. Identification of key genes, transcription factors and microRNAs involved in intracranial aneurysm. Mol Med Rep. 2017;: pubmed publisher
    ..of the upregulated DEGs were significantly enriched in the immune system development category, including CD40 ligand (CD40LG) and CD40 and the downregulated DEGs, such as striatin (STRN), were enriched in neuron projection ..
  70. Okamatsu N, Sakai N, Karakawa A, Kouyama N, Sato Y, Inagaki K, et al. Biological effects of anti-RANKL antibody administration in pregnant mice and their newborns. Biochem Biophys Res Commun. 2017;491:614-621 pubmed publisher
    ..mass as compared with the controls, while osteoclast number and the level of tartrate-resistant acid phosphatase (TRAP) in serum were increased at the end of pregnancy...
  71. Aan de Kerk D, Jansen M, Jolles S, Warnatz K, Seneviratne S, ten Berge I, et al. Phenotypic and Functional Comparison of Class Switch Recombination Deficiencies with a Subgroup of Common Variable Immunodeficiencies. J Clin Immunol. 2016;36:656-66 pubmed publisher
    ..CVID patients by a direct functional comparison with patients having genetically well-characterized CSR defects in CD40L, activation-induced cytidine deaminase (AID) and uracil N-glycosylase activity (UNG)...
  72. Zeng X, Zhang Y, Wang S, Wang K, Tao L, Zou M, et al. Artesunate suppresses RANKL-induced osteoclastogenesis through inhibition of PLC?1-Ca2+-NFATc1 signaling pathway and prevents ovariectomy-induced bone loss. Biochem Pharmacol. 2017;124:57-68 pubmed publisher
    ..5?M. In addition, the NFATc1 targeted osteoclast-specific genes expression including cathepsin K, MMP-9, and TRAP was reduced by artesunate...
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    ..i>Methods. The influence of 12/15-LOX on B cell phenotype and function, and IgM generation, was compared using wildtype (WT) and 12/15-LOX (Alox15-/-) deficient mice...
  74. Foradori C, Zimmerman A, Coder P, Peachee V, Handa R, Kimber I, et al. Lack of immunotoxic effects of repeated exposure to atrazine associated with the adaptation of adrenal gland activation. Regul Toxicol Pharmacol. 2017;89:200-214 pubmed publisher
    T cell-dependent IgM antibody production and natural killer cell (NKC) activity were assessed in SD rats orally administered atrazine for 28 days to males (0, 6...
  75. Li L, Sapkota M, Gao M, Choi H, Soh Y. Macrolactin F inhibits RANKL-mediated osteoclastogenesis by suppressing Akt, MAPK and NFATc1 pathways and promotes osteoblastogenesis through a BMP-2/smad/Akt/Runx2 signaling pathway. Eur J Pharmacol. 2017;815:202-209 pubmed publisher
    ..suppressed the expression of osteoclast-related genes, including c-myc, RANK, tartrate-resistant acid phosphatase (TRAP), nuclear factor of activated T cells c1 (NFATc1), cathepsin K and matrix metalloproteinase 9 (MMP9)...
  76. Chen S, Li F, Hsu T, Liang S, Yeh Y, Liao W, et al. CLEC5A is a critical receptor in innate immunity against Listeria infection. Nat Commun. 2017;8:299 pubmed publisher
    ..Here we show that CLEC5A is involved in neutrophil extracellular trap formation and the production of reactive oxygen species and proinflammatory cytokines in response to Listeria ..
  77. van Delft M, Verheul M, Burgers L, Derksen V, van der Helm van Mil A, Van der Woude D, et al. The isotype and IgG subclass distribution of anti-carbamylated protein antibodies in rheumatoid arthritis patients. Arthritis Res Ther. 2017;19:190 pubmed publisher
    ..Anti-CarP antibody IgM, IgA, and IgG or IgG subclasses were detected by enzyme-linked immunosorbent assay (ELISA) in sera from 373 ..