CD40

Summary

Gene Symbol: CD40
Description: CD40 molecule
Alias: Bp50, CDW40, TNFRSF5, p50, tumor necrosis factor receptor superfamily member 5, B cell surface antigen CD40, B cell-associated molecule, CD40 molecule, TNF receptor superfamily member 5, CD40L receptor
Species: human
Products:     CD40

Top Publications

  1. Chu P, Deforce D, Pedersen I, Kim Y, Kitada S, Reed J, et al. Latent sensitivity to Fas-mediated apoptosis after CD40 ligation may explain activity of CD154 gene therapy in chronic lymphocytic leukemia. Proc Natl Acad Sci U S A. 2002;99:3854-9 pubmed
    ..CD4 T cell lines can induce apoptosis of CD40-activated CLL cells via a CD95 ligand (CD95-L)-dependent mechanism...
  2. Mach F, Schonbeck U, Sukhova G, Bourcier T, Bonnefoy J, Pober J, et al. Functional CD40 ligand is expressed on human vascular endothelial cells, smooth muscle cells, and macrophages: implications for CD40-CD40 ligand signaling in atherosclerosis. Proc Natl Acad Sci U S A. 1997;94:1931-6 pubmed
    Increasing evidence supports involvement of inflammation and immunity in atherogenesis. We report here that CD40 ligand (CD40L), an immunoregulatory signaling molecule heretofore considered largely restricted to recently activated CD4+ T ..
  3. van Kooten C, Banchereau J. CD40-CD40 ligand. J Leukoc Biol. 2000;67:2-17 pubmed
    b>CD40 is a cell surface receptor that belongs to the tumor necrosis factor-R (TNF-R) family, and that was first identified and functionally characterized on B lymphocytes...
  4. Sato T, Irie S, Reed J. A novel member of the TRAF family of putative signal transducing proteins binds to the cytosolic domain of CD40. FEBS Lett. 1995;358:113-8 pubmed
    b>CD40 is a member of the tumor necrosis factor receptor (TNF-R) family that regulates B-lymphocyte proliferation, immunoglobulin class-switching, and apoptosis through poorly defined signal transduction mechanisms...
  5. Deregibus M, Buttiglieri S, Russo S, Bussolati B, Camussi G. CD40-dependent activation of phosphatidylinositol 3-kinase/Akt pathway mediates endothelial cell survival and in vitro angiogenesis. J Biol Chem. 2003;278:18008-14 pubmed
    b>CD40 has been involved in tumor and inflammatory neoangiogenesis...
  6. Tsukamoto N, Kobayashi N, Azuma S, Yamamoto T, Inoue J. Two differently regulated nuclear factor kappaB activation pathways triggered by the cytoplasmic tail of CD40. Proc Natl Acad Sci U S A. 1999;96:1234-9 pubmed
    b>CD40 signaling modulates the immune response at least in part by activation of nuclear factor kappaB (NFkappaB)...
  7. Kurylowicz A, Kula D, Ploski R, Skorka A, Jurecka Lubieniecka B, Zebracka J, et al. Association of CD40 gene polymorphism (C-1T) with susceptibility and phenotype of Graves' disease. Thyroid. 2005;15:1119-24 pubmed
    Recently, a functional polymorphism in the CD40 gene at position -1, C to T change (C-1T) has been identified and the C/C genotype has been reported to be associated with Graves' disease (GD)...
  8. Zheng J, Liu Y, Lau Y, Tu W. CD40-activated B cells are more potent than immature dendritic cells to induce and expand CD4(+) regulatory T cells. Cell Mol Immunol. 2010;7:44-50 pubmed publisher
    ..Both CD40-activated B cells (CD40-B) and immature dendritic cells (imDCs) have been used as professional antigen-presenting ..
  9. Pluvinet R, Olivar R, Krupinski J, Herrero Fresneda I, Luque A, Torras J, et al. CD40: an upstream master switch for endothelial cell activation uncovered by RNAi-coupled transcriptional profiling. Blood. 2008;112:3624-37 pubmed publisher
    ..To delineate comprehensively the involvement of CD40 (TNFRSF5) in EC activation, we combined RNAi-mediated CD40 knockdown with comparative genome-wide transcriptional ..

More Information

Publications78

  1. Cheng G, Cleary A, Ye Z, Hong D, Lederman S, Baltimore D. Involvement of CRAF1, a relative of TRAF, in CD40 signaling. Science. 1995;267:1494-8 pubmed
    b>CD40 is a receptor on the surface of B lymphocytes, the activation of which leads to B cell survival, growth, and differentiation...
  2. Tone M, Tone Y, Fairchild P, Wykes M, Waldmann H. Regulation of CD40 function by its isoforms generated through alternative splicing. Proc Natl Acad Sci U S A. 2001;98:1751-6 pubmed
    b>CD40 is a member of the tumor necrosis factor receptor superfamily...
  3. Tian C, Qin W, Li L, Zheng W, Qiu F. A common polymorphism in CD40 Kozak sequence (-1C/T) is associated with acute coronary syndrome. Biomed Pharmacother. 2010;64:191-4 pubmed publisher
    Evidence suggests the CD40-CD40L pathway as a key process in the development, progression, and outcome of acute coronary syndrome (ACS)...
  4. Liu R, Xu N, Wang X, Shen L, Zhao G, Zhang H, et al. Influence of MIF, CD40, and CD226 polymorphisms on risk of rheumatoid arthritis. Mol Biol Rep. 2012;39:6915-22 pubmed publisher
    ..The CD40 is also crucial for some relevant functions of the immune system and may be related to rheumatoid arthritis (RA)...
  5. Burdon K, Langefeld C, Beck S, Wagenknecht L, Carr J, Rich S, et al. Variants of the CD40 gene but not of the CD40L gene are associated with coronary artery calcification in the Diabetes Heart Study (DHS). Am Heart J. 2006;151:706-11 pubmed
    b>CD40/CD40L signaling is known to play an important role in immune response. The proteins are expressed in a variety of cell types and ligation causes cells to produce inflammatory cytokines and cellular adhesion molecules...
  6. Humphreys E, Williams K, Adams D, Afford S. Primary and malignant cholangiocytes undergo CD40 mediated Fas dependent apoptosis, but are insensitive to direct activation with exogenous Fas ligand. PLoS ONE. 2010;5:e14037 pubmed publisher
    ..tightly regulated via co-operative interactions between two tumour necrosis family (TNF) receptor family members; CD40 and Fas (CD95)...
  7. Tomer Y, Concepcion E, Greenberg D. A C/T single-nucleotide polymorphism in the region of the CD40 gene is associated with Graves' disease. Thyroid. 2002;12:1129-35 pubmed
    ..Among the genes mapped to 20q11 was the CD40 gene, an important costimulatory molecule and a good positional candidate gene for GD...
  8. Yuan M, Ohishi M, Wang L, Raguki H, Wang H, Tao L, et al. Association between serum levels of soluble CD40/CD40 ligand and organ damage in hypertensive patients. Clin Exp Pharmacol Physiol. 2010;37:848-51 pubmed publisher
    1. CD40 and CD40 ligand (CD40L) have a critical role in the pathophysiology and risk prediction of coronary artery syndrome, including atherothrombosis and atherosclerosis...
  9. Lee H, Korman B, Le J, Kastner D, Remmers E, Gregersen P, et al. Genetic risk factors for rheumatoid arthritis differ in Caucasian and Korean populations. Arthritis Rheum. 2009;60:364-71 pubmed publisher
    ..The aim of this study was to determine whether the genetic variants at 4q27, 6q23, CCL21, TRAF1/C5, and CD40 identified in Caucasians are also associated with RA in a Korean case-control collection...
  10. Moschonas A, Kouraki M, Knox P, Thymiakou E, Kardassis D, Eliopoulos A. CD40 induces antigen transporter and immunoproteasome gene expression in carcinomas via the coordinated action of NF-kappaB and of NF-kappaB-mediated de novo synthesis of IRF-1. Mol Cell Biol. 2008;28:6208-22 pubmed publisher
    ..In this study, we demonstrate that CD40 ligation overcomes this defect through the coordinated action of the transcription factors NF-kappaB and interferon ..
  11. Jacobson E, Huber A, Akeno N, Sivak M, Li C, Concepcion E, et al. A CD40 Kozak sequence polymorphism and susceptibility to antibody-mediated autoimmune conditions: the role of CD40 tissue-specific expression. Genes Immun. 2007;8:205-14 pubmed
    ..others have demonstrated the association of a C/T single nucleotide polymorphism (SNP), in the Kozak sequence of CD40, with Graves' disease (GD)...
  12. Wang C, Yan J, Yang P, Du R, Chen G. The relationship between CD40 gene polymorphism and unstable coronary atherosclerotic plaques. Clin Cardiol. 2010;33:E55-60 pubmed publisher
    Recently, CD40 polymorphism was found to be associated with acute coronary syndromes. However, few study was involved in the relationship between CD40 polymorphism and the risk of the vulnerable plaque to rupture so far...
  13. Barbé Tuana F, Klein D, Ichii H, Berman D, Coffey L, Kenyon N, et al. CD40-CD40 ligand interaction activates proinflammatory pathways in pancreatic islets. Diabetes. 2006;55:2437-45 pubmed
    ..We recently discovered that CD40, a member of tumor necrosis factor (TNF) receptor family, is expressed in pancreatic beta-cells...
  14. Eeva J, Ropponen A, Nuutinen U, Eeva S, Mättö M, Eray M, et al. The CD40-induced protection against CD95-mediated apoptosis is associated with a rapid upregulation of anti-apoptotic c-FLIP. Mol Immunol. 2007;44:1230-7 pubmed
    CD95/Fas and CD40 receptors are important regulators of cell survival during germinal center reaction...
  15. Flaxenburg J, Melter M, Lapchak P, Briscoe D, Pal S. The CD40-induced signaling pathway in endothelial cells resulting in the overexpression of vascular endothelial growth factor involves Ras and phosphatidylinositol 3-kinase. J Immunol. 2004;172:7503-9 pubmed
    Ligation of endothelial cell (EC) CD40 induces the expression of several proinflammatory cytokines as well as angiogenesis factors, including vascular endothelial growth factor (VEGF)...
  16. Mosialos G, Birkenbach M, Yalamanchili R, VanArsdale T, Ware C, Kieff E. The Epstein-Barr virus transforming protein LMP1 engages signaling proteins for the tumor necrosis factor receptor family. Cell. 1995;80:389-99 pubmed
    ..LAP1 binds to the p80 TNFR, CD40, and the lymphotoxin-beta receptor, while EBI6 associates with the p80 TNFR...
  17. Hostager B, Catlett I, Bishop G. Recruitment of CD40 and tumor necrosis factor receptor-associated factors 2 and 3 to membrane microdomains during CD40 signaling. J Biol Chem. 2000;275:15392-8 pubmed
    Signals delivered to antigen-presenting cells through CD40 are critical for the activation of immune responses...
  18. Ishida T, Tojo T, Aoki T, Kobayashi N, Ohishi T, Watanabe T, et al. TRAF5, a novel tumor necrosis factor receptor-associated factor family protein, mediates CD40 signaling. Proc Natl Acad Sci U S A. 1996;93:9437-42 pubmed
    Signals emanating from CD40 play crucial roles in B-cell function. To identify molecules that transduce CD40 signalings, we have used the yeast two-hybrid system to done cDNAs encoding proteins that bind the cytoplasmic tail of CD40...
  19. Companjen A, van der Wel L, Boon L, Prens E, Laman J. CD40 ligation-induced cytokine production in human skin explants is partly mediated via IL-1. Int Immunol. 2002;14:669-76 pubmed
    b>CD40 ligation by CD40 ligand(+) CD4(+) T cells has been claimed to be involved in inflammatory responses in human skin...
  20. Shuang C, Dalin L, Weiguang Y, Zhenkun F, Fengyan X, Da P, et al. Association of CD40 gene polymorphisms with sporadic breast cancer in Chinese Han women of Northeast China. PLoS ONE. 2011;6:e23762 pubmed publisher
    ..The co-stimulatory molecule CD40 plays a prominent role in immune regulation and homeostasis...
  21. Bennett S, Carbone F, Karamalis F, Flavell R, Miller J, Heath W. Help for cytotoxic-T-cell responses is mediated by CD40 signalling. Nature. 1998;393:478-80 pubmed
    ..Here we show that signalling through CD40 on the antigen-presenting cells can replace the requirement for TH cells, indicating that T-cell 'help', at least ..
  22. Hanissian S, Geha R. Jak3 is associated with CD40 and is critical for CD40 induction of gene expression in B cells. Immunity. 1997;6:379-87 pubmed
    b>CD40 is a receptor that is critical for the survival, growth, differentiation, and isotype switching of B lymphocytes...
  23. Nieters A, Bracci P, de Sanjose S, Becker N, Maynadie M, Benavente Y, et al. A functional TNFRSF5 polymorphism and risk of non-Hodgkin lymphoma, a pooled analysis. Int J Cancer. 2011;128:1481-5 pubmed publisher
    ..studies that are part of this pooling study implicate a functional polymorphism (-1C>T, rs1883832) in the TNFRSF5 gene encoding CD40 in the etiology of follicular lymphoma...
  24. Hu H, O Rourke K, Boguski M, Dixit V. A novel RING finger protein interacts with the cytoplasmic domain of CD40. J Biol Chem. 1994;269:30069-72 pubmed
    b>CD40 is a member of the tumor necrosis factor receptor family and, like other members, it appears to possess no intrinsic signaling capacity (e.g...
  25. Park J, Chang H, Park C, Jang A, Park B, Rhim T, et al. Association analysis of CD40 polymorphisms with asthma and the level of serum total IgE. Am J Respir Crit Care Med. 2007;175:775-82 pubmed
    The CD40 protein plays important roles in cell-mediated and humoral immune responses, especially in immunoglobulin class-switching to IgE...
  26. Hachem A, Yacoub D, Zaid Y, Mourad W, Merhi Y. Involvement of nuclear factor ?B in platelet CD40 signaling. Biochem Biophys Res Commun. 2012;425:58-63 pubmed publisher
    b>CD40 ligand (CD40L) is a thrombo-inflammatory molecule that predicts cardiovascular events...
  27. Li R, Chen W, Pang X, Tian W, Wang W, Zhang X. CD40 signal expression in gastric cancer tissue and its correlation with prognosis of gastric cancer patients. Mol Biol Rep. 2012;39:8741-7 pubmed publisher
    b>CD40 signaling plays a critical role in the survival rate of gastric cancer patients...
  28. Knox P, Davies C, Ioannou M, Eliopoulos A. The death domain kinase RIP1 links the immunoregulatory CD40 receptor to apoptotic signaling in carcinomas. J Cell Biol. 2011;192:391-9 pubmed publisher
    b>CD40, a tumor necrosis factor (TNF) receptor family member, is widely recognized for its prominent role in the antitumor immune response...
  29. Ahmed Choudhury J, Russell C, Randhawa S, Young L, Adams D, Afford S, et al. Differential induction of nuclear factor-kappaB and activator protein-1 activity after CD40 ligation is associated with primary human hepatocyte apoptosis or intrahepatic endothelial cell proliferation. Mol Biol Cell. 2003;14:1334-45 pubmed
    b>CD40, a tumor necrosis factor receptor superfamily member, is up-regulated on intraheptatic endothelial cells (IHEC) and epithelial cells during inflammatory liver disease, and there is evidence that the functional outcome of CD40 ..
  30. Reinders M, Sho M, Robertson S, Geehan C, Briscoe D. Proangiogenic function of CD40 ligand-CD40 interactions. J Immunol. 2003;171:1534-41 pubmed
    ..However, little is known of the immunologic mediators of angiogenesis factor production. Interactions between CD40 ligand (CD40L) and CD40 have been shown to have pluripotent functions in inflammation, including the production of ..
  31. Arlestig L, Rantapaa Dahlqvist S. Polymorphisms of the genes encoding CD40 and growth differentiation factor 15 and in the 9p21.3 region in patients with rheumatoid arthritis and cardiovascular disease. J Rheumatol. 2012;39:939-45 pubmed publisher
    ..in the genes coding for growth differentiation factor 15 (GDF15)/monocyte inhibitory cytokine-1 (MIC-1; rs1058587), CD40 (rs1535045 and rs3765459), and the 9p21.3 locus (rs1333049)...
  32. Onouchi Y, Onoue S, Tamari M, Wakui K, Fukushima Y, Yashiro M, et al. CD40 ligand gene and Kawasaki disease. Eur J Hum Genet. 2004;12:1062-8 pubmed
    ..One of the identified peaks was located on the Xq26 region. A recent report of elevated expression of CD40 ligand (CD40L), which maps to Xq26, during the acute-phase KD, and its relationship to the development of coronary ..
  33. Yacoub D, Hachem A, Théorêt J, Gillis M, Mourad W, Merhi Y. Enhanced levels of soluble CD40 ligand exacerbate platelet aggregation and thrombus formation through a CD40-dependent tumor necrosis factor receptor-associated factor-2/Rac1/p38 mitogen-activated protein kinase signaling pathway. Arterioscler Thromb Vasc Biol. 2010;30:2424-33 pubmed publisher
    b>CD40 ligand is a thromboinflammatory molecule that predicts cardiovascular events...
  34. Ha Y, Seul H, Lee J. Ligation of CD40 receptor in human B lymphocytes triggers the 5-lipoxygenase pathway to produce reactive oxygen species and activate p38 MAPK. Exp Mol Med. 2011;43:101-10 pubmed
    Previously, we reported that CD40-induced production of reactive oxygen species (ROS) by NADPH oxidase requires the TNF receptor-associated factor (TRAF) 3, as well as the activities of phosphatidylinositol 3-kinase (PI3K) and Rac1...
  35. Plant D, Flynn E, Mbarek H, Dieude P, Cornelis F, Arlestig L, et al. Investigation of potential non-HLA rheumatoid arthritis susceptibility loci in a European cohort increases the evidence for nine markers. Ann Rheum Dis. 2010;69:1548-53 pubmed publisher
    ..Eight markers (ie, rs1160542 (AFF3), rs1678542 (KIF5A), rs2476601 (PTPN22), rs3087243 (CTLA4), rs4810485 (CD40), rs5029937 (6q23), rs10760130 (TRAF1/C5) and rs7574865 (STAT4)) were significantly associated with RA by meta-..
  36. Gandhi K, McKay F, Cox M, Riveros C, Armstrong N, Heard R, et al. The multiple sclerosis whole blood mRNA transcriptome and genetic associations indicate dysregulation of specific T cell pathways in pathogenesis. Hum Mol Genet. 2010;19:2134-43 pubmed publisher
    ..screen identified two novel regions with genome wide significance: one encoding the T cell co-stimulatory molecule, CD40; the other a region on chromosome 12q13-14...
  37. Orozco G, Eyre S, Hinks A, Ke X, Wilson A, Bax D, et al. Association of CD40 with rheumatoid arthritis confirmed in a large UK case-control study. Ann Rheum Dis. 2010;69:813-6 pubmed publisher
    ..association studies (GWAS) in populations of European descent reported novel associations of markers mapping to the CD40, CCL21 and CDK6 genes with rheumatoid arthritis (RA) susceptibility while a large-scale, case-control association ..
  38. Zhang B, Wu T, Song C, Chen M, Li H, Guo R. Association of CD40--1C/T polymorphism with cerebral infarction susceptibility and its effect on sCD40L in Chinese population. Int Immunopharmacol. 2013;16:461-5 pubmed publisher
    This study aims to determine whether functional polymorphism of CD40 is associated with the cerebral infarction (CI) susceptibility, and to investigate the effect of CD40 gene polymorphism on CD40 mRNA expression in PBMCs and plasma ..
  39. Wu Y, Wang L, He X, Xu H, Zhou L, Zhao F, et al. Expression of CD40 and growth-inhibitory activity of CD40 ligand in colon cancer ex vivo. Cell Immunol. 2008;253:102-9 pubmed publisher
    b>CD40, a member of the tumor necrosis factor receptor superfamily, is widely expressed on various cell types. Some studies show that CD40 expression is related to several carcinomas, where its function remains largely unknown...
  40. Chen K, Huang J, Gong W, Zhang L, Yu P, Wang J. CD40/CD40L dyad in the inflammatory and immune responses in the central nervous system. Cell Mol Immunol. 2006;3:163-9 pubmed
    b>CD40 and its cognate ligand (CD40L) are a pair of regulators of pro-inflammatory and immune responses...
  41. Pullen S, Miller H, Everdeen D, Dang T, Crute J, Kehry M. CD40-tumor necrosis factor receptor-associated factor (TRAF) interactions: regulation of CD40 signaling through multiple TRAF binding sites and TRAF hetero-oligomerization. Biochemistry. 1998;37:11836-45 pubmed
    b>CD40 is a TNF receptor superfamily member that provides activation signals in antigen-presenting cells such as B cells, macrophages, and dendritic cells...
  42. Skibola C, Nieters A, Bracci P, Curry J, Agana L, Skibola D, et al. A functional TNFRSF5 gene variant is associated with risk of lymphoma. Blood. 2008;111:4348-54 pubmed publisher
    ..We hypothesized that single nucleotide polymorphisms (SNPs) in TNFRSF5 and TNFSF5 encoding the CD40 and CD154 proteins, respectively, influence lymphoma risk, particularly a functional ..
  43. Baxendale A, Dawson C, Stewart S, Mudaliar V, Reynolds G, Gordon J, et al. Constitutive activation of the CD40 pathway promotes cell transformation and neoplastic growth. Oncogene. 2005;24:7913-23 pubmed
    b>CD40, a tumour necrosis factor (TNF) receptor family member, is expressed in a variety of cell types, including B lymphocytes, macrophages, fibroblasts, endothelial and epithelial cells, and this widespread expression is likely to account ..
  44. Muthumani K, Hwang D, Choo A, Mayilvahanan S, Dayes N, Thieu K, et al. HIV-1 Vpr inhibits the maturation and activation of macrophages and dendritic cells in vitro. Int Immunol. 2005;17:103-16 pubmed
    ..delivered protein, Vpr down-modulated the expression of several immunologically important molecules including CD40, CD80, CD83 and CD86 costimulatory molecules on MDM (monocyte-derived macrophage) and MDDC (monocyte-derived ..
  45. Davies C, Mak T, Young L, Eliopoulos A. TRAF6 is required for TRAF2-dependent CD40 signal transduction in nonhemopoietic cells. Mol Cell Biol. 2005;25:9806-19 pubmed
    The emerging role of CD40, a tumor necrosis factor (TNF) receptor family member, in immune regulation, disease pathogenesis, and cancer therapy necessitates the analysis of CD40 signal transduction in a wide range of tissue types...
  46. Rothe M, Sarma V, Dixit V, Goeddel D. TRAF2-mediated activation of NF-kappa B by TNF receptor 2 and CD40. Science. 1995;269:1424-7 pubmed
    ..The role of TRAFs in the TNF-R2 and CD40 signal transduction pathways, which result in the activation of transcription factor NF-kappa B, was investigated...
  47. Buck D, Kroner A, Rieckmann P, Maurer M, Wiendl H. Analysis of the C/T(-1) single nucleotide polymorphism in the CD40 gene in multiple sclerosis. Tissue Antigens. 2006;68:335-8 pubmed
    The costimulatory CD40-CD40L pathway plays a critical role in the generation and maintenance of adaptive immune responses...
  48. Rodriguez Rodriguez L, Castañeda S, Vazquez Rodriguez T, Morado I, Marí Alfonso B, Gomez Vaquero C, et al. Influence of CD40 rs1883832 polymorphism in susceptibility to and clinical manifestations of biopsy-proven giant cell arteritis. J Rheumatol. 2010;37:2076-80 pubmed publisher
    To assess the potential association between CD40 rs1883832 polymorphism and biopsy-proven giant cell arteritis (GCA)...
  49. Blanco Kelly F, Matesanz F, Alcina A, Teruel M, Díaz Gallo L, Gómez Garcia M, et al. CD40: novel association with Crohn's disease and replication in multiple sclerosis susceptibility. PLoS ONE. 2010;5:e11520 pubmed publisher
    A functional polymorphism located at -1 from the start codon of the CD40 gene, rs1883832, was previously reported to disrupt a Kozak sequence essential for translation...
  50. Chakrabarti S, Blair P, Freedman J. CD40-40L signaling in vascular inflammation. J Biol Chem. 2007;282:18307-17 pubmed
    Ligation of CD40 in circulating cells or in the vessel wall may promote mononuclear cell recruitment, participate in the weakening of the plaque, and contribute to thrombosis...
  51. Li Y, Tian C, Wang M, Xia Z. [Correlation of CD40 gene polymorphisms with acute coronary syndrome, hypertension and diabetes]. Zhonghua Yi Xue Za Zhi. 2007;87:690-4 pubmed
    To investigate the correlation of CD40-E1SNP (-1C/T) and CD40-E4SNP with acute coronary syndrome (ACS), hypertension and diabetes in Chinese Han population...
  52. Kashiwada M, Shirakata Y, Inoue J, Nakano H, Okazaki K, Okumura K, et al. Tumor necrosis factor receptor-associated factor 6 (TRAF6) stimulates extracellular signal-regulated kinase (ERK) activity in CD40 signaling along a ras-independent pathway. J Exp Med. 1998;187:237-44 pubmed
    b>CD40 activates nuclear factor kappa B (NF kappa B) and the mitogen-activated protein kinase (MAPK) subfamily, including extracellular signal-regulated kinase (ERK)...
  53. Henn V, Slupsky J, Grafe M, Anagnostopoulos I, Forster R, Müller Berghaus G, et al. CD40 ligand on activated platelets triggers an inflammatory reaction of endothelial cells. Nature. 1998;391:591-4 pubmed
    b>CD40 ligand (CD40L, CD154), a transmembrane protein structurally related to the cytokine TNF-alpha, was originally identified on stimulated CD4+ T cells, and later on stimulated mast cells and basophils...
  54. . Genome-wide association study identifies new multiple sclerosis susceptibility loci on chromosomes 12 and 20. Nat Genet. 2009;41:824-8 pubmed publisher
    ..4 x 10(-11); rs10876994, P = 2.7 x 10(-10); rs12368653, P = 1.0 x 10(-7)) and upstream of CD40 on chromosome 20q13 (rs6074022, P = 1.3 x 10(-7); rs1569723, P = 2.9 x 10(-7))...
  55. Qi C, Zheng L, Ma H, Fei M, Qian K, Shen B, et al. A novel mutation in CD40 and its functional characterization. Hum Mutat. 2009;30:985-94 pubmed publisher
    b>CD40 is a costimulatory protein expressed on the surface of many different cells. It delivers signals regulating diverse cellular responses, including proliferation, differentiation, growth suppression, and cell death...
  56. Peters A, Plenge R, Graham R, Altshuler D, Moser K, Gaffney P, et al. A novel polymorphism of the human CD40 receptor with enhanced function. Blood. 2008;112:1863-71 pubmed publisher
    b>CD40 signaling is critical for innate and adaptive immunity against pathogens, and the cytoplasmic domain of CD40 is highly conserved both within and between species...
  57. Raychaudhuri S, Remmers E, Lee A, Hackett R, Guiducci C, Burtt N, et al. Common variants at CD40 and other loci confer risk of rheumatoid arthritis. Nat Genet. 2008;40:1216-23 pubmed publisher
    ..We identified a common variant at the CD40 gene locus (rs4810485, P = 0.0032 replication, P = 8.2 x 10(-9) overall, OR = 0.87)...
  58. Grammer A, Slota R, Fischer R, Gur H, Girschick H, Yarboro C, et al. Abnormal germinal center reactions in systemic lupus erythematosus demonstrated by blockade of CD154-CD40 interactions. J Clin Invest. 2003;112:1506-20 pubmed
    To determine the role of CD154-CD40 interactions in the B cell overactivity exhibited by patients with active systemic lupus erythematosus (SLE), CD19+ peripheral B cells were examined before and after treatment with humanized anti-CD154 ..
  59. Mukundan L, Bishop G, Head K, Zhang L, Wahl L, Suttles J. TNF receptor-associated factor 6 is an essential mediator of CD40-activated proinflammatory pathways in monocytes and macrophages. J Immunol. 2005;174:1081-90 pubmed
    The interaction between CD40 and its ligand, CD154, has been shown to play a role in the onset and maintenance of inflammatory disease...
  60. García Bermúdez M, González Juanatey C, López Mejías R, Teruel M, Corrales A, Miranda Filloy J, et al. Study of association of CD40-CD154 gene polymorphisms with disease susceptibility and cardiovascular risk in Spanish rheumatoid arthritis patients. PLoS ONE. 2012;7:e49214 pubmed publisher
    ..Since CD40-CD154 binding has direct consequences on inflammation process initiation, we aimed to replicate previous findings ..
  61. Vazgiourakis V, Zervou M, Choulaki C, Bertsias G, Melissourgaki M, Yilmaz N, et al. A common SNP in the CD40 region is associated with systemic lupus erythematosus and correlates with altered CD40 expression: implications for the pathogenesis. Ann Rheum Dis. 2011;70:2184-90 pubmed publisher
    ..SLE) sustained CD40L expression by T cells and platelets activates a variety of cells via its receptor CD40 contributing to disease pathogenesis...
  62. Ban Y, Tozaki T, Taniyama M, Tomita M, Ban Y. Association of a C/T single-nucleotide polymorphism in the 5' untranslated region of the CD40 gene with Graves' disease in Japanese. Thyroid. 2006;16:443-6 pubmed
    ..Furthermore, a novel single nucleotide polymorphism (SNP) in the CD40 gene, which is located in 20q11, was found to be associated and linked with GD in Caucasians and in Koreans...
  63. Fuller B, Nishimura T, Noelle R. The selective triggering of CD40 on keratinocytes in vivo enhances cell-mediated immunity. Eur J Immunol. 2002;32:895-902 pubmed
    b>CD40 is expressed on a wide array of hematopoietic and non-hematopoietic cells, including keratinocytes...
  64. Wang M, Li Y, Li W, Xia Z, Wu Q. The CD40 gene polymorphism rs1883832 is associated with risk of acute coronary syndrome in a Chinese case-control study. DNA Cell Biol. 2011;30:173-8 pubmed publisher
    ..A functional polymorphism (-1C>T, rs1883832) in the 5' untranslated region of TNFRSF5 gene has been reported to affect CD40 expression and be associated with several chronic inflammatory and ..
  65. Williams K, Young S, Negus A, Young L, Adams D, Afford S. C4b binding protein binds to CD154 preventing CD40 mediated cholangiocyte apoptosis: a novel link between complement and epithelial cell survival. PLoS ONE. 2007;2:e159 pubmed
    Activation of CD40 on hepatocytes and cholangiocytes is critical for amplifying Fas-mediated apoptosis in the human liver...
  66. del Rio Espinola A, Fernandez Cadenas I, Rubiera M, Quintana M, Domingues Montanari S, Mendioroz M, et al. CD40-1C>T polymorphism (rs1883832) is associated with brain vessel reocclusion after fibrinolysis in ischemic stroke. Pharmacogenomics. 2010;11:763-72 pubmed publisher
    ..25; 95% CI: 2.23-104.46; adjusted p = 0.006) and the rs1883832 SNP from CD40 gene (OR: 0.077; 95% CI: 0.009-0.66; adjusted p = 0...
  67. Alabraba E, Lai V, Boon L, Wigmore S, Adams D, Afford S. Coculture of human liver macrophages and cholangiocytes leads to CD40-dependent apoptosis and cytokine secretion. Hepatology. 2008;47:552-62 pubmed
    ..We have previously reported that activation of CD40 on cholangiocytes with either soluble CD154 or cross-linking monoclonal antibody to CD40 induces apoptosis in vitro...
  68. Dölen Y, Yilmaz G, Esendagli G, Guler N, Guc D. CD40 -1C>T single nucleotide polymorphism and CD40 expression on breast tumors. Cytokine. 2010;50:243-4 pubmed publisher
  69. Yan J, Wang C, Du R, Liu P, Chen G. Association analysis of CD40 gene polymorphism with acute coronary syndrome. Clin Exp Med. 2010;10:253-8 pubmed publisher
    Current evidence shows that the CD40-CD40 ligand (CD40-CD40L) system plays a crucial role in the development, progression and outcome of acute coronary syndrome (ACS)...