CD36

Summary

Gene Symbol: CD36
Description: CD36 molecule
Alias: BDPLT10, CHDS7, FAT, GP3B, GP4, GPIV, PASIV, SCARB3, platelet glycoprotein 4, CD36 antigen (collagen type I receptor, thrombospondin receptor), CD36 molecule (thrombospondin receptor), GPIIIB, PAS IV, PAS-4 protein, cluster determinant 36, fatty acid translocase, glycoprotein IIIb, leukocyte differentiation antigen CD36, platelet glycoprotein IV, scavenger receptor class B, member 3
Species: human
Products:     CD36

Top Publications

  1. Kunjathoor V, Febbraio M, Podrez E, Moore K, Andersson L, Koehn S, et al. Scavenger receptors class A-I/II and CD36 are the principal receptors responsible for the uptake of modified low density lipoprotein leading to lipid loading in macrophages. J Biol Chem. 2002;277:49982-8 pubmed
    ..The genetic inactivation of either of two SR family members, SR-A or CD36, has been shown previously to reduce oxidized LDL uptake in vitro and atherosclerotic lesions in mice...
  2. Collins R, Touret N, Kuwata H, Tandon N, Grinstein S, Trimble W. Uptake of oxidized low density lipoprotein by CD36 occurs by an actin-dependent pathway distinct from macropinocytosis. J Biol Chem. 2009;284:30288-97 pubmed publisher
    The class B scavenger receptor CD36 has numerous ligands that include modified forms of low density lipoprotein, fibrillar amyloid, apoptotic cells, and Plasmodium falciparum-infected red blood cells, linking this molecule to ..
  3. Fry A, Ghansa A, Small K, Palma A, Auburn S, Diakite M, et al. Positive selection of a CD36 nonsense variant in sub-Saharan Africa, but no association with severe malaria phenotypes. Hum Mol Genet. 2009;18:2683-92 pubmed publisher
    The prevalence of CD36 deficiency in East Asian and African populations suggests that the causal variants are under selection by severe malaria...
  4. Corpeleijn E, van der Kallen C, Kruijshoop M, Magagnin M, de Bruin T, Feskens E, et al. Direct association of a promoter polymorphism in the CD36/FAT fatty acid transporter gene with Type 2 diabetes mellitus and insulin resistance. Diabet Med. 2006;23:907-11 pubmed
    The membrane-bound fatty acid transporter CD36/FAT may play a role in disturbed fatty acid handling as observed in the metabolic syndrome and Type 2 diabetes mellitus (T2DM)...
  5. Erdman L, Cosio G, Helmers A, Gowda D, Grinstein S, Kain K. CD36 and TLR interactions in inflammation and phagocytosis: implications for malaria. J Immunol. 2009;183:6452-9 pubmed publisher
    b>CD36 participates in macrophage internalization of a variety of particles, and has been implicated in inflammatory responses to many of these ligands...
  6. Love Gregory L, Sherva R, Sun L, Wasson J, Schappe T, Doria A, et al. Variants in the CD36 gene associate with the metabolic syndrome and high-density lipoprotein cholesterol. Hum Mol Genet. 2008;17:1695-704 pubmed publisher
    ..Within this region, the CD36 gene, which encodes a membrane receptor for long-chain fatty acids and lipoproteins, is a potentially important ..
  7. Bessho H, Honda S, Kondo N, Kusuhara S, Tsukahara Y, Negi A. The association of CD36 variants with polypoidal choroidal vasculopathy compared to typical neovascular age-related macular degeneration. Mol Vis. 2012;18:121-7 pubmed
    To clarify the association of cluster of differentiation 36 (CD36) variants with polypoidal choroidal vasculopathy (PCV) and compare them with those in typical neovascular age-related macular degeneration (tAMD).
  8. Miquilena Colina M, Lima Cabello E, Sanchez Campos S, Garcia Mediavilla M, Fernandez Bermejo M, Lozano Rodríguez T, et al. Hepatic fatty acid translocase CD36 upregulation is associated with insulin resistance, hyperinsulinaemia and increased steatosis in non-alcoholic steatohepatitis and chronic hepatitis C. Gut. 2011;60:1394-402 pubmed publisher
    b>Fatty acid translocase CD36 (FAT/CD36) mediates uptake and intracellular transport of long-chain fatty acids in diverse cell types...
  9. D Archivio M, Scazzocchio B, Filesi C, Varì R, Maggiorella M, Sernicola L, et al. Oxidised LDL up-regulate CD36 expression by the Nrf2 pathway in 3T3-L1 preadipocytes. FEBS Lett. 2008;582:2291-8 pubmed publisher
    The effect of oxLDL on CD36 expression has been assessed in preadipocytes induced to differentiate...

More Information

Publications92

  1. Primo L, Ferrandi C, Roca C, Marchio S, di Blasio L, Alessio M, et al. Identification of CD36 molecular features required for its in vitro angiostatic activity. FASEB J. 2005;19:1713-5 pubmed
    Thrombospondin-1 (TSP-1), a natural inhibitor of angiogenesis, acts directly on endothelial cells (EC) via CD36 to inhibit their migration and morphogenesis induced by basic fibroblast growth factor...
  2. Zeng Y, Tao N, Chung K, Heuser J, Lublin D. Endocytosis of oxidized low density lipoprotein through scavenger receptor CD36 utilizes a lipid raft pathway that does not require caveolin-1. J Biol Chem. 2003;278:45931-6 pubmed
    The scavenger receptor CD36 binds a diverse array of ligands, including thrombospondin-1, oxidized low density lipoprotein (OxLDL), fatty acids, anionic phospholipids, and apoptotic cells...
  3. Oquendo P, Hundt E, Lawler J, Seed B. CD36 directly mediates cytoadherence of Plasmodium falciparum parasitized erythrocytes. Cell. 1989;58:95-101 pubmed
    ..In apparent reconciliation of these findings, it has been reported that the OKM5 antigen (CD36) is a receptor for thrombospondin...
  4. Kondo N, Honda S, Kuno S, Negi A. Positive association of common variants in CD36 with neovascular age-related macular degeneration. Aging (Albany NY). 2009;1:266-74 pubmed
    ..Oxidative stress is a hypothesized pathway for the pathophysiology of AMD. CD36 was chosen as a candidate gene for neovascular AMD because the protein plays an important role in this pathway as ..
  5. Kanayama M, Yamaguchi S, Shibata T, Shibata N, Kobayashi M, Nagai R, et al. Identification of a serum component that regulates cyclooxygenase-2 gene expression in cooperation with 4-hydroxy-2-nonenal. J Biol Chem. 2007;282:24166-74 pubmed
    ..induction is regulated by two sets of signaling mechanisms, one for the up-regulation of the scavenger receptor CD36 by HNE and one for the CD36-mediated COX induction by oxidized LDL...
  6. Winograd E, Eda S, Sherman I. Chemical modifications of band 3 protein affect the adhesion of Plasmodium falciparum-infected erythrocytes to CD36. Mol Biochem Parasitol. 2004;136:243-8 pubmed
    ..anion exchanger, band 3 protein (AE1), in the adhesion of Plasmodium falciparum-infected erythrocytes to CD36 and thrombospondin (TSP) was studied...
  7. Andersen M, Lenhard B, Whatling C, Eriksson P, Odeberg J. Alternative promoter usage of the membrane glycoprotein CD36. BMC Mol Biol. 2006;7:8 pubmed
    b>CD36 is a membrane glycoprotein involved in a variety of cellular processes such as lipid transport, immune regulation, hemostasis, adhesion, angiogenesis and atherosclerosis...
  8. Amodu O, Gbadegesin R, Ralph S, Adeyemo A, Brenchley P, Ayoola O, et al. Plasmodium falciparum malaria in south-west Nigerian children: is the polymorphism of ICAM-1 and E-selectin genes contributing to the clinical severity of malaria?. Acta Trop. 2005;95:248-55 pubmed
    ..genes coding for four human adhesion molecules at six different loci (ICAM-1 exons 2, 4 and 6, E-selectin exon 2, CD36 exon 10, and PECAM exon 3) were studied...
  9. Tontonoz P, Nagy L, Alvarez J, Thomazy V, Evans R. PPARgamma promotes monocyte/macrophage differentiation and uptake of oxidized LDL. Cell. 1998;93:241-52 pubmed
    ..monocytic differentiation and promotes uptake of oxLDL through transcriptional induction of the scavenger receptor CD36. These results reveal a novel signaling pathway controlling differentiation and lipid metabolism in monocytic cells,..
  10. Kazerounian S, Duquette M, Reyes M, Lawler J, Song K, Perruzzi C, et al. Priming of the vascular endothelial growth factor signaling pathway by thrombospondin-1, CD36, and spleen tyrosine kinase. Blood. 2011;117:4658-66 pubmed publisher
    b>CD36 plays a critical role in the inhibition of angiogenesis through binding to the type 1 repeats of thrombospondin-1 (TSP-1) and activating Fyn tyrosine kinase and MAPK pathways...
  11. Taylor K, Tang Y, Sobieski D, Lipsky R. Characterization of two alternatively spliced 5'-untranslated exons of the human CD36 gene in different cell types. Gene. 1993;133:205-12 pubmed
    ..6-kb BamHI-EcoRI fragment from the 5'-end of the human gene encoding the cell adhesion receptor, CD36. This region contains the first coding exon, exon 3, as well as two non-coding exons, exons 2a and 2b, from the 5'-..
  12. Renga B, Francisci D, D Amore C, Schiaroli E, Mencarelli A, Cipriani S, et al. The HIV matrix protein p17 subverts nuclear receptors expression and induces a STAT1-dependent proinflammatory phenotype in monocytes. PLoS ONE. 2012;7:e35924 pubmed publisher
    ..human p17 induces the expression of proinflammatory and proatherogenic genes (MCP-1, ICAM-1, CD40, CD86 and CD36) while downregulating the expression of nuclear receptors (FXR and PPAR?) that counter-regulate the proinflammatory ..
  13. Pain A, Urban B, Kai O, Casals Pascual C, Shafi J, Marsh K, et al. A non-sense mutation in Cd36 gene is associated with protection from severe malaria. Lancet. 2001;357:1502-3 pubmed
    We sought genetic evidence for the importance of host-parasite interactions involving CD36 in severe malaria...
  14. Davis S, Amrein M, Gillrie M, Lee K, Muruve D, Ho M. Plasmodium falciparum-induced CD36 clustering rapidly strengthens cytoadherence via p130CAS-mediated actin cytoskeletal rearrangement. FASEB J. 2012;26:1119-30 pubmed publisher
    ..cells generated a mean ± sd adhesion force of 167 ± 208 pN from the formation of single or multiple bonds with CD36. The strength of adhesion increased by 5- to 6-fold within minutes of contact through a signaling pathway initiated ..
  15. Koonen D, Jensen M, Handberg A. Soluble CD36- a marker of the (pathophysiological) role of CD36 in the metabolic syndrome?. Arch Physiol Biochem. 2011;117:57-63 pubmed publisher
    b>CD36 is a class B scavenger receptor observed in many cell types and tissues throughout the body...
  16. Yipp B, Hickey M, Andonegui G, Murray A, Looareesuwan S, Kubes P, et al. Differential roles of CD36, ICAM-1, and P-selectin in Plasmodium falciparum cytoadherence in vivo. Microcirculation. 2007;14:593-602 pubmed
    ..More importantly, the effect of TNF-alpha could be seen only in the presence of CD36. A further increase in adhesion by 4.9-fold was observed after 24 h of TNF-alpha stimulation...
  17. Omi K, Ohashi J, Patarapotikul J, Hananantachai H, Naka I, Looareesuwan S, et al. CD36 polymorphism is associated with protection from cerebral malaria. Am J Hum Genet. 2003;72:364-74 pubmed
    The human protein CD36 is a major receptor for Plasmodium falciparum-infected erythrocytes and contributes to the pathology of P. falciparum malaria...
  18. Rać M, Safranow K, Rać M, Kurzawski G, Krzystolik A, Sagasz Tysiewicz D, et al. CD36 gene is associated with thickness of atheromatous plaque and ankle-brachial index in patients with early coronary artery disease. Kardiol Pol. 2012;70:918-23 pubmed
    b>CD36 is a multifunctional molecule engaged in the removal of oxidised LDL from plasma...
  19. Mo M, Lee H, Kotaka M, Niang M, Gao X, Iyer J, et al. The C-terminal segment of the cysteine-rich interdomain of Plasmodium falciparum erythrocyte membrane protein 1 determines CD36 binding and elicits antibodies that inhibit adhesion of parasite-infected erythrocytes. Infect Immun. 2008;76:1837-47 pubmed publisher
    ..The interaction between CIDRalpha and CD36 promotes stable adherence of parasitized erythrocytes to endothelial cells...
  20. Mwaikambo B, Yang C, Chemtob S, Hardy P. Hypoxia up-regulates CD36 expression and function via hypoxia-inducible factor-1- and phosphatidylinositol 3-kinase-dependent mechanisms. J Biol Chem. 2009;284:26695-707 pubmed publisher
    ..Hypoxia or reduced oxygen tension is considered central to the pathogenesis of these disorders. Although the CD36 scavenger receptor features prominently in ocular homeostasis and pathology, little is known regarding its ..
  21. Isenberg J, Jia Y, Fukuyama J, Switzer C, Wink D, Roberts D. Thrombospondin-1 inhibits nitric oxide signaling via CD36 by inhibiting myristic acid uptake. J Biol Chem. 2007;282:15404-15 pubmed
    ..cell nitric oxide signaling in a CD36-dependent manner, we examined the ability of TSP1 to modulate the fatty acid translocase activity of CD36. TSP1 and a CD36 antibody that mimics the activity of TSP1 inhibited myristate uptake...
  22. Bechmann L, Gieseler R, Sowa J, Kahraman A, Erhard J, Wedemeyer I, et al. Apoptosis is associated with CD36/fatty acid translocase upregulation in non-alcoholic steatohepatitis. Liver Int. 2010;30:850-9 pubmed publisher
    ..sections, FATPs as well as select parameters of extrinsic and intrinsic apoptosis were found to be upregulated (CD36/FAT: x 11.56; FATP-5: x 1.33; CD95/Fas: x 3.18; NOXA: x 2.79)...
  23. Bonen A, Parolin M, Steinberg G, Calles Escandon J, Tandon N, Glatz J, et al. Triacylglycerol accumulation in human obesity and type 2 diabetes is associated with increased rates of skeletal muscle fatty acid transport and increased sarcolemmal FAT/CD36. FASEB J. 2004;18:1144-6 pubmed
    ..individuals, the increased sarcolemmal LCFA transport rate was not associated with an altered expression of FAT/CD36 or FABPpm...
  24. Ochola L, Siddondo B, Ocholla H, Nkya S, Kimani E, Williams T, et al. Specific receptor usage in Plasmodium falciparum cytoadherence is associated with disease outcome. PLoS ONE. 2011;6:e14741 pubmed publisher
    ..this study we have examined the cytoadherence patterns of 101 patient isolates from varying clinical syndromes to CD36 and ICAM-1, and have used variant ICAM-1 proteins to further characterise this adhesive phenotype...
  25. Kashiwagi H, Tomiyama Y, Honda S, Kosugi S, Shiraga M, Nagao N, et al. Molecular basis of CD36 deficiency. Evidence that a 478C-->T substitution (proline90-->serine) in CD36 cDNA accounts for CD36 deficiency. J Clin Invest. 1995;95:1040-6 pubmed
    b>CD36 deficiency is divided into two subgroups: neither platelets nor monocytes express CD36 (type I deficiency), and monocytes express CD36 in spite of the lack of platelet CD36 (type II deficiency)...
  26. Heni M, Müssig K, Machicao F, Machann J, Schick F, Claussen C, et al. Variants in the CD36 gene locus determine whole-body adiposity, but have no independent effect on insulin sensitivity. Obesity (Silver Spring). 2011;19:1004-9 pubmed publisher
    b>CD36 variants have been associated with type 2 diabetes, features of the metabolic syndrome, and alterations in lipid metabolism...
  27. Griffin E, Re A, Hamel N, Fu C, Bush H, McCaffrey T, et al. A link between diabetes and atherosclerosis: Glucose regulates expression of CD36 at the level of translation. Nat Med. 2001;7:840-6 pubmed
    ..Here we report a glucose-mediated increase in CD36 mRNA translation efficiency that results in increased expression of the macrophage scavenger receptor CD36...
  28. Stewart C, Stuart L, Wilkinson K, van Gils J, Deng J, Halle A, et al. CD36 ligands promote sterile inflammation through assembly of a Toll-like receptor 4 and 6 heterodimer. Nat Immunol. 2010;11:155-61 pubmed publisher
    ..Assembly of this newly identified heterodimer is regulated by signals from the scavenger receptor CD36, a common receptor for these disparate ligands...
  29. Gao D, Ashraf M, Kar N, Lin D, Sayre L, Podrez E. Structural basis for the recognition of oxidized phospholipids in oxidized low density lipoproteins by class B scavenger receptors CD36 and SR-BI. J Biol Chem. 2010;285:4447-54 pubmed publisher
    Specific oxidized phospholipids (oxPC(CD36)) accumulate in vivo at sites of oxidative stress and serve as high affinity ligands for scavenger receptors class B (CD36 and SR-BI)...
  30. Rasouli N, Yao Borengasser A, Varma V, Spencer H, McGehee R, Peterson C, et al. Association of scavenger receptors in adipose tissue with insulin resistance in nondiabetic humans. Arterioscler Thromb Vasc Biol. 2009;29:1328-35 pubmed publisher
    ..The gene expression of scavenger receptors including scavenger receptor-A (SRA), CD36, and lectin-like oxidized LDL receptor-1 (LOX-1) were studied in subcutaneous adipose tissue of nondiabetic ..
  31. Armesilla A, Vega M. Structural organization of the gene for human CD36 glycoprotein. J Biol Chem. 1994;269:18985-91 pubmed
    The cell-surface glycoprotein CD36 interacts with a large variety of ligands, including collagen types I and IV, thrombospondin, erythrocytes parasitized with Plasmodium falciparum, platelet-agglutinating protein p37, oxidized low density ..
  32. Fernández Ruiz E, Armesilla A, Sanchez Madrid F, Vega M. Gene encoding the collagen type I and thrombospondin receptor CD36 is located on chromosome 7q11.2. Genomics. 1993;17:759-61 pubmed
    The human CD36 is a member of a gene family of structurally related glycoproteins and functions as a receptor for collagen type I and thrombospondin...
  33. Xanthis A, Hatzitolios A, Fidani S, Befani C, Giannakoulas G, Koliakos G. Receptor of advanced glycation end products (RAGE) positively regulates CD36 expression and reactive oxygen species production in human monocytes in diabetes. Angiology. 2009;60:772-9 pubmed publisher
    ..AGEs also act as CD36 ligands...
  34. Goyenechea E, COLLINS L, Parra D, Liu G, Snieder H, Swaminathan R, et al. CD36 gene promoter polymorphisms are associated with low density lipoprotein-cholesterol in normal twins and after a low-calorie diet in obese subjects. Twin Res Hum Genet. 2008;11:621-8 pubmed publisher
    Common polymorphisms of the CD36 fatty acid transporter gene have been associated with lipid metabolism and cardiovascular disease...
  35. Baranova I, Kurlander R, Bocharov A, Vishnyakova T, Chen Z, Remaley A, et al. Role of human CD36 in bacterial recognition, phagocytosis, and pathogen-induced JNK-mediated signaling. J Immunol. 2008;181:7147-56 pubmed
    Scavenger receptor CD36 mediates Staphylococcus aureus phagocytosis and initiates TLR2/6 signaling...
  36. Klein M, Gittis A, Su H, Makobongo M, Moore J, Singh S, et al. The cysteine-rich interdomain region from the highly variable plasmodium falciparum erythrocyte membrane protein-1 exhibits a conserved structure. PLoS Pathog. 2008;4:e1000147 pubmed publisher
    ..Almost all parasites isolated directly from patients bind the human CD36 receptor...
  37. Imai M, Tanaka T, Kintaka T, Ikemoto T, Shimizu A, Kitaura Y. Genomic heterogeneity of type II CD36 deficiency. Clin Chim Acta. 2002;321:97-106 pubmed
    b>CD36 deficiency has been classified in two types, i.e., type I and type II CD36 deficiency. Possible pathological involvement of CD36 deficiency has been suggested in humans, but is still confounding...
  38. Lepretre F, Linton K, Lacquemant C, Vatin V, Samson C, Dina C, et al. Genetic study of the CD36 gene in a French diabetic population. Diabetes Metab. 2004;30:459-63 pubmed
    b>CD36 is a multifunctional membrane receptor widely expressed in different tissues which binds and internalizes oxidized low-density lipoprotein...
  39. Ma X, Bacci S, Mlynarski W, Gottardo L, Soccio T, Menzaghi C, et al. A common haplotype at the CD36 locus is associated with high free fatty acid levels and increased cardiovascular risk in Caucasians. Hum Mol Genet. 2004;13:2197-205 pubmed
    b>CD36 is a class B scavenger receptor recognizing a variety of ligands including long-chain fatty acids and modified LDL...
  40. Triantafilou M, Gamper F, Haston R, Mouratis M, Morath S, Hartung T, et al. Membrane sorting of toll-like receptor (TLR)-2/6 and TLR2/1 heterodimers at the cell surface determines heterotypic associations with CD36 and intracellular targeting. J Biol Chem. 2006;281:31002-11 pubmed
    ..attributed to its unique ability to heterodimerize with TLRs 1 and 6 and, most recently, to its association with CD36 in response to diacylated lipoproteins...
  41. Handberg A, Levin K, Højlund K, Beck Nielsen H. Identification of the oxidized low-density lipoprotein scavenger receptor CD36 in plasma: a novel marker of insulin resistance. Circulation. 2006;114:1169-76 pubmed
    Macrophage CD36 scavenges oxidized low-density lipoprotein, leading to foam cell formation, and appears to be a key proatherogenic molecule...
  42. Yanai H, Watanabe I, Ishii K, Morimoto M, Fujiwara H, Yoshida S, et al. Attenuated aerobic exercise capacity in CD36 deficiency. J Med Genet. 2007;44:445-7 pubmed
    An important role of CD36 in muscle fatty acid (FA) uptake has been shown in CD36-knockout or CD36-overexpressed mice. FA is a predominant substrate in energy production during light exercise below the anaerobic threshold (AT)...
  43. Rać M, Safranow K, Poncyljusz W. Molecular basis of human CD36 gene mutations. Mol Med. 2007;13:288-96 pubmed
    b>CD36 is a transmembrane glycoprotein of the class B scavenger receptor family. The CD36 gene is located on chromosome 7 q11.2 and is encoded by 15 exons...
  44. Noushmehr H, D Amico E, Farilla L, Hui H, Wawrowsky K, Mlynarski W, et al. Fatty acid translocase (FAT/CD36) is localized on insulin-containing granules in human pancreatic beta-cells and mediates fatty acid effects on insulin secretion. Diabetes. 2005;54:472-81 pubmed
    The membrane receptor FAT/CD36 facilitates the major fraction of long-chain fatty acid (FA) uptake by muscle and adipose tissues...
  45. Knowles J, Wang H, Itakura H, Southwick A, Myers R, Iribarren C, et al. Association of polymorphisms in platelet and hemostasis system genes with acute myocardial infarction. Am Heart J. 2007;154:1052-8 pubmed
    ..An SNP in CD36 (rs3211956) was significantly (P = ...
  46. Smith T, Serghides L, Patel S, Febbraio M, Silverstein R, Kain K. CD36-mediated nonopsonic phagocytosis of erythrocytes infected with stage I and IIA gametocytes of Plasmodium falciparum. Infect Immun. 2003;71:393-400 pubmed
    ..Using a number of experimental strategies, we found that the scavenger receptor CD36 mediates the uptake of nonopsonized erythrocytes infected with stage I and IIA gametocytes of Plasmodium falciparum ..
  47. Aitman T, Cooper L, Norsworthy P, Wahid F, Gray J, Curtis B, et al. Malaria susceptibility and CD36 mutation. Nature. 2000;405:1015-6 pubmed
  48. Iwai N, Tago N, Yasui N, Kokubo Y, Inamoto N, Tomoike H, et al. Genetic analysis of 22 candidate genes for hypertension in the Japanese population. J Hypertens. 2004;22:1119-26 pubmed
    ..The candidate genes were selected based on their functions, including insulin resistance (APM1, CD36, HSD11B1), oxidative stress (CYBA, GPX1, GSTMs), steroid hormone (ESR1, ESR2, HSD11B2), renal functions (PTGS2, ..
  49. Ghosh A, Murugesan G, Chen K, Zhang L, Wang Q, Febbraio M, et al. Platelet CD36 surface expression levels affect functional responses to oxidized LDL and are associated with inheritance of specific genetic polymorphisms. Blood. 2011;117:6355-66 pubmed publisher
    b>CD36 modulates platelet function via binding to oxidized LDL (oxLDL), cell-derived microparticles, and thrombospondin-1...
  50. Roberts W, Magwenzi S, Aburima A, Naseem K. Thrombospondin-1 induces platelet activation through CD36-dependent inhibition of the cAMP/protein kinase A signaling cascade. Blood. 2010;116:4297-306 pubmed publisher
    ..Here we show that thrombospondin-1 (TSP-1) prevents cAMP/protein kinase A (PKA) signaling through a CD36-dependent mechanism...
  51. Sampson M, Davies I, Braschi S, Ivory K, Hughes D. Increased expression of a scavenger receptor (CD36) in monocytes from subjects with Type 2 diabetes. Atherosclerosis. 2003;167:129-34 pubmed
    Uptake of modified low density lipoprotein (LDL) by monocyte-macrophages is mediated by the scavenger receptor CD36, which is upregulated in vitro by high glucose concentrations and oxidatively modified LDL...
  52. Houssier M, Raoul W, Lavalette S, Keller N, Guillonneau X, Baragatti B, et al. CD36 deficiency leads to choroidal involution via COX2 down-regulation in rodents. PLoS Med. 2008;5:e39 pubmed publisher
    ..The aim of this study is to elucidate the possible implication of the scavenger receptor CD36 in retinal degeneration and choroidal involution, the cardinal features of the dry form of AMD...
  53. Jaqaman K, Kuwata H, Touret N, Collins R, Trimble W, Danuser G, et al. Cytoskeletal control of CD36 diffusion promotes its receptor and signaling function. Cell. 2011;146:593-606 pubmed publisher
    ..We used single-molecule tracking to investigate the dynamics of CD36, a clustering-responsive receptor that mediates oxidized LDL uptake by macrophages...
  54. Kintaka T, Tanaka T, Imai M, Adachi I, Narabayashi I, Kitaura Y. CD36 genotype and long-chain fatty acid uptake in the heart. Circ J. 2002;66:819-25 pubmed
    Homozygous or compound heterozygous mutation of the CD36 gene (CD36-/-) in humans results in severe defects of the uptake of long-chain fatty acids (LCFAs) in the heart...
  55. Hanawa H, Watanabe K, Nakamura T, Ogawa Y, Toba K, Fuse I, et al. Identification of cryptic splice site, exon skipping, and novel point mutations in type I CD36 deficiency. J Med Genet. 2002;39:286-91 pubmed
  56. Lepretre F, Vasseur F, Vaxillaire M, Scherer P, Ali S, Linton K, et al. A CD36 nonsense mutation associated with insulin resistance and familial type 2 diabetes. Hum Mutat. 2004;24:104 pubmed
    Mutations in CD36 / fatty acid translocase (FAT) gene are responsible for insulin resistance in the rat but contribution to human Type 2 diabetes is unknown...
  57. Malaud E, Hourton D, Giroux L, Ninio E, Buckland R, McGregor J. The terminal six amino-acids of the carboxy cytoplasmic tail of CD36 contain a functional domain implicated in the binding and capture of oxidized low-density lipoprotein. Biochem J. 2002;364:507-15 pubmed
    b>CD36, a major adhesion molecule expressed by monocytes/macrophages, plays a key role in the binding and internalization of oxidized low-density lipoprotein (OxLDL)...
  58. Rać M, Suchy J, Kurzawski G, Kurlapska A, Safranow K, Rać M, et al. Polymorphism of the CD36 Gene and Cardiovascular Risk Factors in Patients with Coronary Artery Disease Manifested at a Young Age. Biochem Genet. 2012;50:103-11 pubmed publisher
    This study investigates potential associations between CD36 gene variants and the presence of risk factors in Caucasians with coronary artery disease (CAD) manifested at a young age...
  59. Su X, Abumrad N. Cellular fatty acid uptake: a pathway under construction. Trends Endocrinol Metab. 2009;20:72-7 pubmed publisher
    ..b>CD36 facilitates a major fraction of FA uptake by key tissues...
  60. Rios F, Jancar S, Melo I, Ketelhuth D, Gidlund M. Role of PPAR-gamma in the modulation of CD36 and FcgammaRII induced by LDL with low and high degrees of oxidation during the differentiation of the monocytic THP-1 cell line. Cell Physiol Biochem. 2008;22:549-56 pubmed publisher
    ..The levels of scavenger receptor CD36 are increased in atherosclerotic lesions and there is evidence that some components of oxLDL auto-regulate the ..
  61. Meroni L, Riva A, Morelli P, Galazzi M, Mologni D, Adorni F, et al. Increased CD36 expression on circulating monocytes during HIV infection. J Acquir Immune Defic Syndr. 2005;38:310-3 pubmed
    ..b>CD36 is a multifunctional receptor with a wide tissue distribution that plays a crucial role in the cellular uptake and ..
  62. Zhang J, Crandall I. Expression of both N- and C-terminal GFP tagged huCD36 and their discrepancy in OxLDL and pRBC binding on CHO cells. Lipids Health Dis. 2007;6:24 pubmed
    b>CD36, an 88 kDa membrane glycoprotein, is found in several cell types and it has been characterized to have two hydrophobic domains at their N- and C-termini which are essential for protein folding and targeting...
  63. Yuasa Kawase M, Masuda D, Yamashita T, Kawase R, Nakaoka H, Inagaki M, et al. Patients with CD36 deficiency are associated with enhanced atherosclerotic cardiovascular diseases. J Atheroscler Thromb. 2012;19:263-75 pubmed
    ..A class B scavenger receptor, CD36, is a receptor for oxidized LDL and a transporter of long-chain fatty acids...
  64. Zamora C, Cantó E, Nieto J, Angels Ortiz M, Juarez C, Vidal S. Functional consequences of CD36 downregulation by TLR signals. Cytokine. 2012;60:257-65 pubmed publisher
    ..mononuclear cells (PBMC) with TLR2 (Pam3CSK4 and FSL1) and TLR4 ligand lipopolysaccharide (LPS) and then analyzed CD36 expression on different monocyte subpopulations by flow cytometry...
  65. Handberg A, Norberg M, Stenlund H, Hallmans G, Attermann J, Eriksson J. Soluble CD36 (sCD36) clusters with markers of insulin resistance, and high sCD36 is associated with increased type 2 diabetes risk. J Clin Endocrinol Metab. 2010;95:1939-46 pubmed publisher
    Soluble CD36 (sCD36) may be an early marker of insulin resistance and atherosclerosis...
  66. Calvo D, Gomez Coronado D, Suarez Y, Lasuncion M, Vega M. Human CD36 is a high affinity receptor for the native lipoproteins HDL, LDL, and VLDL. J Lipid Res. 1998;39:777-88 pubmed
    ..b>CD36, a multigland glycoprotein structurally related to SR-BI and CLA-1, has been reported to bind oxidized low density ..
  67. Miao W, Vasile E, Lane W, Lawler J. CD36 associates with CD9 and integrins on human blood platelets. Blood. 2001;97:1689-96 pubmed
    The membrane glycoprotein CD36 is involved in platelet aggregation, inhibition of angiogenesis, atherosclerosis, and sequestration of malaria-parasitized erythrocytes...
  68. Laugerette F, Passilly Degrace P, Patris B, Niot I, Febbraio M, Montmayeur J, et al. CD36 involvement in orosensory detection of dietary lipids, spontaneous fat preference, and digestive secretions. J Clin Invest. 2005;115:3177-84 pubmed
    ..The fatty acid transporter CD36 appears to be a plausible candidate for this function since it has a high affinity for long-chain fatty acids (..
  69. Love Gregory L, Sherva R, Schappe T, Qi J, McCrea J, Klein S, et al. Common CD36 SNPs reduce protein expression and may contribute to a protective atherogenic profile. Hum Mol Genet. 2011;20:193-201 pubmed publisher
    Membrane CD36 functions in the uptake of fatty acids (FAs), oxidized lipoproteins and in signal transduction after binding these ligands. In rodents, CD36 is implicated in abnormal lipid metabolism, inflammation and atherosclerosis...
  70. Rać M, Suchy J, Kurzawski G, Safranow K, Jakubowska K, Olszewska M, et al. Analysis of human CD36 gene sequence alterations in the oxidized low-density lipoprotein-binding region using denaturing high-performance liquid chromatography. Genet Test Mol Biomarkers. 2010;14:551-7 pubmed publisher
    ..could be a simple and cost-effective screening method for mutations and polymorphisms in exons 4, 5, and 6 of the CD36 gene, which encode the protein region responsible for the removal of oxidized low-density lipoprotein...
  71. Kuniyasu A, Ohgami N, Hayashi S, Miyazaki A, Horiuchi S, Nakayama H. CD36-mediated endocytic uptake of advanced glycation end products (AGE) in mouse 3T3-L1 and human subcutaneous adipocytes. FEBS Lett. 2003;537:85-90 pubmed
    ..We here show that AGE-modified bovine serum albumin (BSA) is endocytosed by adipocytes via CD36. Upon differentiation, 3T3-L1 and human subcutaneous adipose cells showed marked increases in endocytic uptake and ..
  72. Serghides L, Nathoo S, Walmsley S, Kain K. CD36 deficiency induced by antiretroviral therapy. AIDS. 2002;16:353-8 pubmed
    ..To examine whether ARV therapy might inhibit the expression of CD36, which is known to play an important role in fatty acid and glucose metabolism, and if this might contribute to the ..
  73. Chilongola J, Balthazary S, Mpina M, Mhando M, Mbugi E. CD36 deficiency protects against malarial anaemia in children by reducing Plasmodium falciparum-infected red blood cell adherence to vascular endothelium. Trop Med Int Health. 2009;14:810-6 pubmed publisher
    b>CD36 is a receptor that occurs on the surface of activated immune cells, vascular endothelial cells and participates in phagocytosis and lipid metabolism...
  74. Tandon N, Kralisz U, Jamieson G. Identification of glycoprotein IV (CD36) as a primary receptor for platelet-collagen adhesion. J Biol Chem. 1989;264:7576-83 pubmed
    The role of glycoprotein IV (GPIV) in platelet activation processes has been examined by several different approaches: (i) Fab fragments of a monospecific polyclonal antibody to purified platelet GPIV (approximately 20 micrograms/ml) ..
  75. Park Y, Febbraio M, Silverstein R. CD36 modulates migration of mouse and human macrophages in response to oxidized LDL and may contribute to macrophage trapping in the arterial intima. J Clin Invest. 2009;119:136-45 pubmed publisher
    ..However, the mechanism by which this occurs is not clearly defined. Here, we tested in mice the hypothesis that CD36, a class B scavenger receptor expressed on macrophages, has a role in this process...
  76. Schwenk R, Luiken J, Eckel J. FIP2 and Rip11 specify Rab11a-mediated cellular distribution of GLUT4 and FAT/CD36 in H9c2-hIR cells. Biochem Biophys Res Commun. 2007;363:119-25 pubmed
    ..two of its effectors, Rip11 and FIP2, in H9c2-hIR cells and measured the cell surface abundance of GLUT4myc and FAT/CD36. We observed that by knocking down Rab11a, both GLUT4myc and FAT/CD36 abundance at the plasma membrane were ..
  77. Smith J, Su X, El Maghrabi R, Stahl P, Abumrad N. Opposite regulation of CD36 ubiquitination by fatty acids and insulin: effects on fatty acid uptake. J Biol Chem. 2008;283:13578-85 pubmed publisher
    FAT/CD36 is a membrane scavenger receptor that facilitates long chain fatty acid uptake by muscle. Acute increases in membrane CD36 and fatty acid uptake have been reported in response to insulin and contraction...
  78. Teupser D, Mueller M, Koglin J, Wilfert W, Ernst J, von Scheidt W, et al. CD36 mRNA expression is increased in CD14+ monocytes of patients with coronary heart disease. Clin Exp Pharmacol Physiol. 2008;35:552-6 pubmed
    ..scavenger receptor class B member 1 (SRB1), lectin-like oxidized low-density lipoprotein (LDL) receptor 1 (LOX1), CD36, LDL receptor (LDLR)), reverse cholesterol transport (apolipoprotein E (ApoE), ATP-binding cassette sub-family A ..