CD36

Summary

Gene Symbol: CD36
Description: CD36 molecule
Alias: BDPLT10, CHDS7, FAT, GP3B, GP4, GPIV, PASIV, SCARB3, platelet glycoprotein 4, CD36 antigen (collagen type I receptor, thrombospondin receptor), CD36 molecule (thrombospondin receptor), GPIIIB, PAS IV, PAS-4 protein, cluster determinant 36, fatty acid translocase, glycoprotein IIIb, leukocyte differentiation antigen CD36, platelet glycoprotein IV, scavenger receptor class B, member 3
Species: human
Products:     CD36

Top Publications

  1. Rać M, Safranow K, Rać M, Kurzawski G, Krzystolik A, Sagasz Tysiewicz D, et al. CD36 gene is associated with thickness of atheromatous plaque and ankle-brachial index in patients with early coronary artery disease. Kardiol Pol. 2012;70:918-23 pubmed
    b>CD36 is a multifunctional molecule engaged in the removal of oxidised LDL from plasma...
  2. Ochola L, Siddondo B, Ocholla H, Nkya S, Kimani E, Williams T, et al. Specific receptor usage in Plasmodium falciparum cytoadherence is associated with disease outcome. PLoS ONE. 2011;6:e14741 pubmed publisher
    ..this study we have examined the cytoadherence patterns of 101 patient isolates from varying clinical syndromes to CD36 and ICAM-1, and have used variant ICAM-1 proteins to further characterise this adhesive phenotype...
  3. Kashiwagi H, Tomiyama Y, Honda S, Kosugi S, Shiraga M, Nagao N, et al. Molecular basis of CD36 deficiency. Evidence that a 478C-->T substitution (proline90-->serine) in CD36 cDNA accounts for CD36 deficiency. J Clin Invest. 1995;95:1040-6 pubmed
    b>CD36 deficiency is divided into two subgroups: neither platelets nor monocytes express CD36 (type I deficiency), and monocytes express CD36 in spite of the lack of platelet CD36 (type II deficiency)...
  4. Bechmann L, Gieseler R, Sowa J, Kahraman A, Erhard J, Wedemeyer I, et al. Apoptosis is associated with CD36/fatty acid translocase upregulation in non-alcoholic steatohepatitis. Liver Int. 2010;30:850-9 pubmed publisher
    ..sections, FATPs as well as select parameters of extrinsic and intrinsic apoptosis were found to be upregulated (CD36/FAT: x 11.56; FATP-5: x 1.33; CD95/Fas: x 3.18; NOXA: x 2.79)...
  5. Isenberg J, Jia Y, Fukuyama J, Switzer C, Wink D, Roberts D. Thrombospondin-1 inhibits nitric oxide signaling via CD36 by inhibiting myristic acid uptake. J Biol Chem. 2007;282:15404-15 pubmed
    ..cell nitric oxide signaling in a CD36-dependent manner, we examined the ability of TSP1 to modulate the fatty acid translocase activity of CD36. TSP1 and a CD36 antibody that mimics the activity of TSP1 inhibited myristate uptake...
  6. Mwaikambo B, Yang C, Chemtob S, Hardy P. Hypoxia up-regulates CD36 expression and function via hypoxia-inducible factor-1- and phosphatidylinositol 3-kinase-dependent mechanisms. J Biol Chem. 2009;284:26695-707 pubmed publisher
    ..Hypoxia or reduced oxygen tension is considered central to the pathogenesis of these disorders. Although the CD36 scavenger receptor features prominently in ocular homeostasis and pathology, little is known regarding its ..
  7. Bonen A, Parolin M, Steinberg G, Calles Escandon J, Tandon N, Glatz J, et al. Triacylglycerol accumulation in human obesity and type 2 diabetes is associated with increased rates of skeletal muscle fatty acid transport and increased sarcolemmal FAT/CD36. FASEB J. 2004;18:1144-6 pubmed
    ..individuals, the increased sarcolemmal LCFA transport rate was not associated with an altered expression of FAT/CD36 or FABPpm...
  8. Mo M, Lee H, Kotaka M, Niang M, Gao X, Iyer J, et al. The C-terminal segment of the cysteine-rich interdomain of Plasmodium falciparum erythrocyte membrane protein 1 determines CD36 binding and elicits antibodies that inhibit adhesion of parasite-infected erythrocytes. Infect Immun. 2008;76:1837-47 pubmed publisher
    ..The interaction between CIDRalpha and CD36 promotes stable adherence of parasitized erythrocytes to endothelial cells...
  9. Triantafilou M, Gamper F, Haston R, Mouratis M, Morath S, Hartung T, et al. Membrane sorting of toll-like receptor (TLR)-2/6 and TLR2/1 heterodimers at the cell surface determines heterotypic associations with CD36 and intracellular targeting. J Biol Chem. 2006;281:31002-11 pubmed
    ..attributed to its unique ability to heterodimerize with TLRs 1 and 6 and, most recently, to its association with CD36 in response to diacylated lipoproteins...
  10. Fernández Ruiz E, Armesilla A, Sanchez Madrid F, Vega M. Gene encoding the collagen type I and thrombospondin receptor CD36 is located on chromosome 7q11.2. Genomics. 1993;17:759-61 pubmed
    The human CD36 is a member of a gene family of structurally related glycoproteins and functions as a receptor for collagen type I and thrombospondin...

Detail Information

Publications62

  1. Rać M, Safranow K, Rać M, Kurzawski G, Krzystolik A, Sagasz Tysiewicz D, et al. CD36 gene is associated with thickness of atheromatous plaque and ankle-brachial index in patients with early coronary artery disease. Kardiol Pol. 2012;70:918-23 pubmed
    b>CD36 is a multifunctional molecule engaged in the removal of oxidised LDL from plasma...
  2. Ochola L, Siddondo B, Ocholla H, Nkya S, Kimani E, Williams T, et al. Specific receptor usage in Plasmodium falciparum cytoadherence is associated with disease outcome. PLoS ONE. 2011;6:e14741 pubmed publisher
    ..this study we have examined the cytoadherence patterns of 101 patient isolates from varying clinical syndromes to CD36 and ICAM-1, and have used variant ICAM-1 proteins to further characterise this adhesive phenotype...
  3. Kashiwagi H, Tomiyama Y, Honda S, Kosugi S, Shiraga M, Nagao N, et al. Molecular basis of CD36 deficiency. Evidence that a 478C-->T substitution (proline90-->serine) in CD36 cDNA accounts for CD36 deficiency. J Clin Invest. 1995;95:1040-6 pubmed
    b>CD36 deficiency is divided into two subgroups: neither platelets nor monocytes express CD36 (type I deficiency), and monocytes express CD36 in spite of the lack of platelet CD36 (type II deficiency)...
  4. Bechmann L, Gieseler R, Sowa J, Kahraman A, Erhard J, Wedemeyer I, et al. Apoptosis is associated with CD36/fatty acid translocase upregulation in non-alcoholic steatohepatitis. Liver Int. 2010;30:850-9 pubmed publisher
    ..sections, FATPs as well as select parameters of extrinsic and intrinsic apoptosis were found to be upregulated (CD36/FAT: x 11.56; FATP-5: x 1.33; CD95/Fas: x 3.18; NOXA: x 2.79)...
  5. Isenberg J, Jia Y, Fukuyama J, Switzer C, Wink D, Roberts D. Thrombospondin-1 inhibits nitric oxide signaling via CD36 by inhibiting myristic acid uptake. J Biol Chem. 2007;282:15404-15 pubmed
    ..cell nitric oxide signaling in a CD36-dependent manner, we examined the ability of TSP1 to modulate the fatty acid translocase activity of CD36. TSP1 and a CD36 antibody that mimics the activity of TSP1 inhibited myristate uptake...
  6. Mwaikambo B, Yang C, Chemtob S, Hardy P. Hypoxia up-regulates CD36 expression and function via hypoxia-inducible factor-1- and phosphatidylinositol 3-kinase-dependent mechanisms. J Biol Chem. 2009;284:26695-707 pubmed publisher
    ..Hypoxia or reduced oxygen tension is considered central to the pathogenesis of these disorders. Although the CD36 scavenger receptor features prominently in ocular homeostasis and pathology, little is known regarding its ..
  7. Bonen A, Parolin M, Steinberg G, Calles Escandon J, Tandon N, Glatz J, et al. Triacylglycerol accumulation in human obesity and type 2 diabetes is associated with increased rates of skeletal muscle fatty acid transport and increased sarcolemmal FAT/CD36. FASEB J. 2004;18:1144-6 pubmed
    ..individuals, the increased sarcolemmal LCFA transport rate was not associated with an altered expression of FAT/CD36 or FABPpm...
  8. Mo M, Lee H, Kotaka M, Niang M, Gao X, Iyer J, et al. The C-terminal segment of the cysteine-rich interdomain of Plasmodium falciparum erythrocyte membrane protein 1 determines CD36 binding and elicits antibodies that inhibit adhesion of parasite-infected erythrocytes. Infect Immun. 2008;76:1837-47 pubmed publisher
    ..The interaction between CIDRalpha and CD36 promotes stable adherence of parasitized erythrocytes to endothelial cells...
  9. Triantafilou M, Gamper F, Haston R, Mouratis M, Morath S, Hartung T, et al. Membrane sorting of toll-like receptor (TLR)-2/6 and TLR2/1 heterodimers at the cell surface determines heterotypic associations with CD36 and intracellular targeting. J Biol Chem. 2006;281:31002-11 pubmed
    ..attributed to its unique ability to heterodimerize with TLRs 1 and 6 and, most recently, to its association with CD36 in response to diacylated lipoproteins...
  10. Fernández Ruiz E, Armesilla A, Sanchez Madrid F, Vega M. Gene encoding the collagen type I and thrombospondin receptor CD36 is located on chromosome 7q11.2. Genomics. 1993;17:759-61 pubmed
    The human CD36 is a member of a gene family of structurally related glycoproteins and functions as a receptor for collagen type I and thrombospondin...
  11. Handberg A, Levin K, Højlund K, Beck Nielsen H. Identification of the oxidized low-density lipoprotein scavenger receptor CD36 in plasma: a novel marker of insulin resistance. Circulation. 2006;114:1169-76 pubmed
    Macrophage CD36 scavenges oxidized low-density lipoprotein, leading to foam cell formation, and appears to be a key proatherogenic molecule...
  12. Yanai H, Watanabe I, Ishii K, Morimoto M, Fujiwara H, Yoshida S, et al. Attenuated aerobic exercise capacity in CD36 deficiency. J Med Genet. 2007;44:445-7 pubmed
    An important role of CD36 in muscle fatty acid (FA) uptake has been shown in CD36-knockout or CD36-overexpressed mice. FA is a predominant substrate in energy production during light exercise below the anaerobic threshold (AT)...
  13. Rać M, Safranow K, Poncyljusz W. Molecular basis of human CD36 gene mutations. Mol Med. 2007;13:288-96 pubmed
    b>CD36 is a transmembrane glycoprotein of the class B scavenger receptor family. The CD36 gene is located on chromosome 7 q11.2 and is encoded by 15 exons...
  14. Knowles J, Wang H, Itakura H, Southwick A, Myers R, Iribarren C, et al. Association of polymorphisms in platelet and hemostasis system genes with acute myocardial infarction. Am Heart J. 2007;154:1052-8 pubmed
    ..An SNP in CD36 (rs3211956) was significantly (P = ...
  15. Klein M, Gittis A, Su H, Makobongo M, Moore J, Singh S, et al. The cysteine-rich interdomain region from the highly variable plasmodium falciparum erythrocyte membrane protein-1 exhibits a conserved structure. PLoS Pathog. 2008;4:e1000147 pubmed publisher
    ..Almost all parasites isolated directly from patients bind the human CD36 receptor...
  16. Baranova I, Kurlander R, Bocharov A, Vishnyakova T, Chen Z, Remaley A, et al. Role of human CD36 in bacterial recognition, phagocytosis, and pathogen-induced JNK-mediated signaling. J Immunol. 2008;181:7147-56 pubmed
    Scavenger receptor CD36 mediates Staphylococcus aureus phagocytosis and initiates TLR2/6 signaling...
  17. Goyenechea E, COLLINS L, Parra D, Liu G, Snieder H, Swaminathan R, et al. CD36 gene promoter polymorphisms are associated with low density lipoprotein-cholesterol in normal twins and after a low-calorie diet in obese subjects. Twin Res Hum Genet. 2008;11:621-8 pubmed publisher
    Common polymorphisms of the CD36 fatty acid transporter gene have been associated with lipid metabolism and cardiovascular disease...
  18. Xanthis A, Hatzitolios A, Fidani S, Befani C, Giannakoulas G, Koliakos G. Receptor of advanced glycation end products (RAGE) positively regulates CD36 expression and reactive oxygen species production in human monocytes in diabetes. Angiology. 2009;60:772-9 pubmed publisher
    ..AGEs also act as CD36 ligands...
  19. Rasouli N, Yao Borengasser A, Varma V, Spencer H, McGehee R, Peterson C, et al. Association of scavenger receptors in adipose tissue with insulin resistance in nondiabetic humans. Arterioscler Thromb Vasc Biol. 2009;29:1328-35 pubmed publisher
    ..The gene expression of scavenger receptors including scavenger receptor-A (SRA), CD36, and lectin-like oxidized LDL receptor-1 (LOX-1) were studied in subcutaneous adipose tissue of nondiabetic ..
  20. Gao D, Ashraf M, Kar N, Lin D, Sayre L, Podrez E. Structural basis for the recognition of oxidized phospholipids in oxidized low density lipoproteins by class B scavenger receptors CD36 and SR-BI. J Biol Chem. 2010;285:4447-54 pubmed publisher
    Specific oxidized phospholipids (oxPC(CD36)) accumulate in vivo at sites of oxidative stress and serve as high affinity ligands for scavenger receptors class B (CD36 and SR-BI)...
  21. Stewart C, Stuart L, Wilkinson K, van Gils J, Deng J, Halle A, et al. CD36 ligands promote sterile inflammation through assembly of a Toll-like receptor 4 and 6 heterodimer. Nat Immunol. 2010;11:155-61 pubmed publisher
    ..Assembly of this newly identified heterodimer is regulated by signals from the scavenger receptor CD36, a common receptor for these disparate ligands...
  22. Heni M, Müssig K, Machicao F, Machann J, Schick F, Claussen C, et al. Variants in the CD36 gene locus determine whole-body adiposity, but have no independent effect on insulin sensitivity. Obesity (Silver Spring). 2011;19:1004-9 pubmed publisher
    b>CD36 variants have been associated with type 2 diabetes, features of the metabolic syndrome, and alterations in lipid metabolism...
  23. Noushmehr H, D Amico E, Farilla L, Hui H, Wawrowsky K, Mlynarski W, et al. Fatty acid translocase (FAT/CD36) is localized on insulin-containing granules in human pancreatic beta-cells and mediates fatty acid effects on insulin secretion. Diabetes. 2005;54:472-81 pubmed
    The membrane receptor FAT/CD36 facilitates the major fraction of long-chain fatty acid (FA) uptake by muscle and adipose tissues...
  24. Lepretre F, Linton K, Lacquemant C, Vatin V, Samson C, Dina C, et al. Genetic study of the CD36 gene in a French diabetic population. Diabetes Metab. 2004;30:459-63 pubmed
    b>CD36 is a multifunctional membrane receptor widely expressed in different tissues which binds and internalizes oxidized low-density lipoprotein...
  25. Ma X, Bacci S, Mlynarski W, Gottardo L, Soccio T, Menzaghi C, et al. A common haplotype at the CD36 locus is associated with high free fatty acid levels and increased cardiovascular risk in Caucasians. Hum Mol Genet. 2004;13:2197-205 pubmed
    b>CD36 is a class B scavenger receptor recognizing a variety of ligands including long-chain fatty acids and modified LDL...
  26. Armesilla A, Vega M. Structural organization of the gene for human CD36 glycoprotein. J Biol Chem. 1994;269:18985-91 pubmed
    The cell-surface glycoprotein CD36 interacts with a large variety of ligands, including collagen types I and IV, thrombospondin, erythrocytes parasitized with Plasmodium falciparum, platelet-agglutinating protein p37, oxidized low density ..
  27. Griffin E, Re A, Hamel N, Fu C, Bush H, McCaffrey T, et al. A link between diabetes and atherosclerosis: Glucose regulates expression of CD36 at the level of translation. Nat Med. 2001;7:840-6 pubmed
    ..Here we report a glucose-mediated increase in CD36 mRNA translation efficiency that results in increased expression of the macrophage scavenger receptor CD36...
  28. Imai M, Tanaka T, Kintaka T, Ikemoto T, Shimizu A, Kitaura Y. Genomic heterogeneity of type II CD36 deficiency. Clin Chim Acta. 2002;321:97-106 pubmed
    b>CD36 deficiency has been classified in two types, i.e., type I and type II CD36 deficiency. Possible pathological involvement of CD36 deficiency has been suggested in humans, but is still confounding...
  29. Zhu W, Smart E. Myristic acid stimulates endothelial nitric-oxide synthase in a CD36- and an AMP kinase-dependent manner. J Biol Chem. 2005;280:29543-50 pubmed
    ..The specific hypothesis tested was that free fatty acid association with CD36, a class B scavenger receptor, induces the activation of endothelial nitric-oxide synthase (eNOS)...
  30. Rać M, Suchy J, Kurzawski G, Kurlapska A, Safranow K, Rać M, et al. Polymorphism of the CD36 Gene and Cardiovascular Risk Factors in Patients with Coronary Artery Disease Manifested at a Young Age. Biochem Genet. 2012;50:103-11 pubmed publisher
    This study investigates potential associations between CD36 gene variants and the presence of risk factors in Caucasians with coronary artery disease (CAD) manifested at a young age...
  31. Jaqaman K, Kuwata H, Touret N, Collins R, Trimble W, Danuser G, et al. Cytoskeletal control of CD36 diffusion promotes its receptor and signaling function. Cell. 2011;146:593-606 pubmed publisher
    ..We used single-molecule tracking to investigate the dynamics of CD36, a clustering-responsive receptor that mediates oxidized LDL uptake by macrophages...
  32. Ghosh A, Murugesan G, Chen K, Zhang L, Wang Q, Febbraio M, et al. Platelet CD36 surface expression levels affect functional responses to oxidized LDL and are associated with inheritance of specific genetic polymorphisms. Blood. 2011;117:6355-66 pubmed publisher
    b>CD36 modulates platelet function via binding to oxidized LDL (oxLDL), cell-derived microparticles, and thrombospondin-1...
  33. Roberts W, Magwenzi S, Aburima A, Naseem K. Thrombospondin-1 induces platelet activation through CD36-dependent inhibition of the cAMP/protein kinase A signaling cascade. Blood. 2010;116:4297-306 pubmed publisher
    ..Here we show that thrombospondin-1 (TSP-1) prevents cAMP/protein kinase A (PKA) signaling through a CD36-dependent mechanism...
  34. Aitman T, Cooper L, Norsworthy P, Wahid F, Gray J, Curtis B, et al. Malaria susceptibility and CD36 mutation. Nature. 2000;405:1015-6 pubmed
  35. Hanawa H, Watanabe K, Nakamura T, Ogawa Y, Toba K, Fuse I, et al. Identification of cryptic splice site, exon skipping, and novel point mutations in type I CD36 deficiency. J Med Genet. 2002;39:286-91 pubmed
  36. Malaud E, Hourton D, Giroux L, Ninio E, Buckland R, McGregor J. The terminal six amino-acids of the carboxy cytoplasmic tail of CD36 contain a functional domain implicated in the binding and capture of oxidized low-density lipoprotein. Biochem J. 2002;364:507-15 pubmed
    b>CD36, a major adhesion molecule expressed by monocytes/macrophages, plays a key role in the binding and internalization of oxidized low-density lipoprotein (OxLDL)...
  37. Su X, Abumrad N. Cellular fatty acid uptake: a pathway under construction. Trends Endocrinol Metab. 2009;20:72-7 pubmed publisher
    ..b>CD36 facilitates a major fraction of FA uptake by key tissues...
  38. Rios F, Jancar S, Melo I, Ketelhuth D, Gidlund M. Role of PPAR-gamma in the modulation of CD36 and FcgammaRII induced by LDL with low and high degrees of oxidation during the differentiation of the monocytic THP-1 cell line. Cell Physiol Biochem. 2008;22:549-56 pubmed publisher
    ..The levels of scavenger receptor CD36 are increased in atherosclerotic lesions and there is evidence that some components of oxLDL auto-regulate the ..
  39. Smith T, Serghides L, Patel S, Febbraio M, Silverstein R, Kain K. CD36-mediated nonopsonic phagocytosis of erythrocytes infected with stage I and IIA gametocytes of Plasmodium falciparum. Infect Immun. 2003;71:393-400 pubmed
    ..Using a number of experimental strategies, we found that the scavenger receptor CD36 mediates the uptake of nonopsonized erythrocytes infected with stage I and IIA gametocytes of Plasmodium falciparum ..
  40. Meroni L, Riva A, Morelli P, Galazzi M, Mologni D, Adorni F, et al. Increased CD36 expression on circulating monocytes during HIV infection. J Acquir Immune Defic Syndr. 2005;38:310-3 pubmed
    ..b>CD36 is a multifunctional receptor with a wide tissue distribution that plays a crucial role in the cellular uptake and ..
  41. Lepretre F, Vasseur F, Vaxillaire M, Scherer P, Ali S, Linton K, et al. A CD36 nonsense mutation associated with insulin resistance and familial type 2 diabetes. Hum Mutat. 2004;24:104 pubmed
    Mutations in CD36 / fatty acid translocase (FAT) gene are responsible for insulin resistance in the rat but contribution to human Type 2 diabetes is unknown...
  42. Iwai N, Tago N, Yasui N, Kokubo Y, Inamoto N, Tomoike H, et al. Genetic analysis of 22 candidate genes for hypertension in the Japanese population. J Hypertens. 2004;22:1119-26 pubmed
    ..The candidate genes were selected based on their functions, including insulin resistance (APM1, CD36, HSD11B1), oxidative stress (CYBA, GPX1, GSTMs), steroid hormone (ESR1, ESR2, HSD11B2), renal functions (PTGS2, ..
  43. Zhang J, Crandall I. Expression of both N- and C-terminal GFP tagged huCD36 and their discrepancy in OxLDL and pRBC binding on CHO cells. Lipids Health Dis. 2007;6:24 pubmed
    b>CD36, an 88 kDa membrane glycoprotein, is found in several cell types and it has been characterized to have two hydrophobic domains at their N- and C-termini which are essential for protein folding and targeting...
  44. Sampson M, Davies I, Braschi S, Ivory K, Hughes D. Increased expression of a scavenger receptor (CD36) in monocytes from subjects with Type 2 diabetes. Atherosclerosis. 2003;167:129-34 pubmed
    Uptake of modified low density lipoprotein (LDL) by monocyte-macrophages is mediated by the scavenger receptor CD36, which is upregulated in vitro by high glucose concentrations and oxidatively modified LDL...
  45. Houssier M, Raoul W, Lavalette S, Keller N, Guillonneau X, Baragatti B, et al. CD36 deficiency leads to choroidal involution via COX2 down-regulation in rodents. PLoS Med. 2008;5:e39 pubmed publisher
    ..The aim of this study is to elucidate the possible implication of the scavenger receptor CD36 in retinal degeneration and choroidal involution, the cardinal features of the dry form of AMD...
  46. Kintaka T, Tanaka T, Imai M, Adachi I, Narabayashi I, Kitaura Y. CD36 genotype and long-chain fatty acid uptake in the heart. Circ J. 2002;66:819-25 pubmed
    Homozygous or compound heterozygous mutation of the CD36 gene (CD36-/-) in humans results in severe defects of the uptake of long-chain fatty acids (LCFAs) in the heart...
  47. Love Gregory L, Sherva R, Schappe T, Qi J, McCrea J, Klein S, et al. Common CD36 SNPs reduce protein expression and may contribute to a protective atherogenic profile. Hum Mol Genet. 2011;20:193-201 pubmed publisher
    Membrane CD36 functions in the uptake of fatty acids (FAs), oxidized lipoproteins and in signal transduction after binding these ligands. In rodents, CD36 is implicated in abnormal lipid metabolism, inflammation and atherosclerosis...
  48. Tandon N, Kralisz U, Jamieson G. Identification of glycoprotein IV (CD36) as a primary receptor for platelet-collagen adhesion. J Biol Chem. 1989;264:7576-83 pubmed
    The role of glycoprotein IV (GPIV) in platelet activation processes has been examined by several different approaches: (i) Fab fragments of a monospecific polyclonal antibody to purified platelet GPIV (approximately 20 micrograms/ml) ..
  49. Zamora C, Cantó E, Nieto J, Angels Ortiz M, Juarez C, Vidal S. Functional consequences of CD36 downregulation by TLR signals. Cytokine. 2012;60:257-65 pubmed publisher
    ..mononuclear cells (PBMC) with TLR2 (Pam3CSK4 and FSL1) and TLR4 ligand lipopolysaccharide (LPS) and then analyzed CD36 expression on different monocyte subpopulations by flow cytometry...
  50. Yuasa Kawase M, Masuda D, Yamashita T, Kawase R, Nakaoka H, Inagaki M, et al. Patients with CD36 deficiency are associated with enhanced atherosclerotic cardiovascular diseases. J Atheroscler Thromb. 2012;19:263-75 pubmed
    ..A class B scavenger receptor, CD36, is a receptor for oxidized LDL and a transporter of long-chain fatty acids...
  51. Laugerette F, Passilly Degrace P, Patris B, Niot I, Febbraio M, Montmayeur J, et al. CD36 involvement in orosensory detection of dietary lipids, spontaneous fat preference, and digestive secretions. J Clin Invest. 2005;115:3177-84 pubmed
    ..The fatty acid transporter CD36 appears to be a plausible candidate for this function since it has a high affinity for long-chain fatty acids (..
  52. Park Y, Febbraio M, Silverstein R. CD36 modulates migration of mouse and human macrophages in response to oxidized LDL and may contribute to macrophage trapping in the arterial intima. J Clin Invest. 2009;119:136-45 pubmed publisher
    ..However, the mechanism by which this occurs is not clearly defined. Here, we tested in mice the hypothesis that CD36, a class B scavenger receptor expressed on macrophages, has a role in this process...
  53. Smith J, Su X, El Maghrabi R, Stahl P, Abumrad N. Opposite regulation of CD36 ubiquitination by fatty acids and insulin: effects on fatty acid uptake. J Biol Chem. 2008;283:13578-85 pubmed publisher
    FAT/CD36 is a membrane scavenger receptor that facilitates long chain fatty acid uptake by muscle. Acute increases in membrane CD36 and fatty acid uptake have been reported in response to insulin and contraction...
  54. Calvo D, Gomez Coronado D, Suarez Y, Lasuncion M, Vega M. Human CD36 is a high affinity receptor for the native lipoproteins HDL, LDL, and VLDL. J Lipid Res. 1998;39:777-88 pubmed
    ..b>CD36, a multigland glycoprotein structurally related to SR-BI and CLA-1, has been reported to bind oxidized low density ..
  55. Chilongola J, Balthazary S, Mpina M, Mhando M, Mbugi E. CD36 deficiency protects against malarial anaemia in children by reducing Plasmodium falciparum-infected red blood cell adherence to vascular endothelium. Trop Med Int Health. 2009;14:810-6 pubmed publisher
    b>CD36 is a receptor that occurs on the surface of activated immune cells, vascular endothelial cells and participates in phagocytosis and lipid metabolism...
  56. Rać M, Suchy J, Kurzawski G, Safranow K, Jakubowska K, Olszewska M, et al. Analysis of human CD36 gene sequence alterations in the oxidized low-density lipoprotein-binding region using denaturing high-performance liquid chromatography. Genet Test Mol Biomarkers. 2010;14:551-7 pubmed publisher
    ..could be a simple and cost-effective screening method for mutations and polymorphisms in exons 4, 5, and 6 of the CD36 gene, which encode the protein region responsible for the removal of oxidized low-density lipoprotein...
  57. Schwenk R, Luiken J, Eckel J. FIP2 and Rip11 specify Rab11a-mediated cellular distribution of GLUT4 and FAT/CD36 in H9c2-hIR cells. Biochem Biophys Res Commun. 2007;363:119-25 pubmed
    ..two of its effectors, Rip11 and FIP2, in H9c2-hIR cells and measured the cell surface abundance of GLUT4myc and FAT/CD36. We observed that by knocking down Rab11a, both GLUT4myc and FAT/CD36 abundance at the plasma membrane were ..
  58. Kuniyasu A, Ohgami N, Hayashi S, Miyazaki A, Horiuchi S, Nakayama H. CD36-mediated endocytic uptake of advanced glycation end products (AGE) in mouse 3T3-L1 and human subcutaneous adipocytes. FEBS Lett. 2003;537:85-90 pubmed
    ..We here show that AGE-modified bovine serum albumin (BSA) is endocytosed by adipocytes via CD36. Upon differentiation, 3T3-L1 and human subcutaneous adipose cells showed marked increases in endocytic uptake and ..
  59. Handberg A, Norberg M, Stenlund H, Hallmans G, Attermann J, Eriksson J. Soluble CD36 (sCD36) clusters with markers of insulin resistance, and high sCD36 is associated with increased type 2 diabetes risk. J Clin Endocrinol Metab. 2010;95:1939-46 pubmed publisher
    Soluble CD36 (sCD36) may be an early marker of insulin resistance and atherosclerosis...
  60. Miao W, Vasile E, Lane W, Lawler J. CD36 associates with CD9 and integrins on human blood platelets. Blood. 2001;97:1689-96 pubmed
    The membrane glycoprotein CD36 is involved in platelet aggregation, inhibition of angiogenesis, atherosclerosis, and sequestration of malaria-parasitized erythrocytes...
  61. Serghides L, Nathoo S, Walmsley S, Kain K. CD36 deficiency induced by antiretroviral therapy. AIDS. 2002;16:353-8 pubmed
    ..To examine whether ARV therapy might inhibit the expression of CD36, which is known to play an important role in fatty acid and glucose metabolism, and if this might contribute to the ..
  62. Teupser D, Mueller M, Koglin J, Wilfert W, Ernst J, von Scheidt W, et al. CD36 mRNA expression is increased in CD14+ monocytes of patients with coronary heart disease. Clin Exp Pharmacol Physiol. 2008;35:552-6 pubmed
    ..scavenger receptor class B member 1 (SRB1), lectin-like oxidized low-density lipoprotein (LDL) receptor 1 (LOX1), CD36, LDL receptor (LDLR)), reverse cholesterol transport (apolipoprotein E (ApoE), ATP-binding cassette sub-family A ..