CD133

Summary

Gene Symbol: CD133
Description: prominin 1
Alias: AC133, CD133, CORD12, MCDR2, MSTP061, PROML1, RP41, STGD4, prominin-1, antigen AC133, hProminin, hematopoietic stem cell antigen, prominin-like protein 1
Species: human
Products:     CD133

Top Publications

  1. Shmelkov S, Jun L, St Clair R, McGarrigle D, Derderian C, Usenko J, et al. Alternative promoters regulate transcription of the gene that encodes stem cell surface protein AC133. Blood. 2004;103:2055-61 pubmed
    b>AC133 is a member of a novel family of cell surface proteins with 5 transmembrane domains. The function of AC133 is unknown...
  2. Florek M, Haase M, Marzesco A, Freund D, Ehninger G, Huttner W, et al. Prominin-1/CD133, a neural and hematopoietic stem cell marker, is expressed in adult human differentiated cells and certain types of kidney cancer. Cell Tissue Res. 2005;319:15-26 pubmed
    ..This lack of detection of human prominin-1, as defined by its glycosylation-dependent AC133 epitope, is surprising given the expression of the murine ortholog in adult epithelia...
  3. Labarge M, Bissell M. Is CD133 a marker of metastatic colon cancer stem cells?. J Clin Invest. 2008;118:2021-4 pubmed publisher
    ..Over the last decade, a large body of literature has implicated the protein CD133 as a marker of organ-specific adult stem cells and in some cancers as a bona fide CSC marker...
  4. Smith L, Nesterova A, Ryan M, Duniho S, Jonas M, Anderson M, et al. CD133/prominin-1 is a potential therapeutic target for antibody-drug conjugates in hepatocellular and gastric cancers. Br J Cancer. 2008;99:100-9 pubmed publisher
    b>CD133/prominin-1 is a pentaspan transmembrane glycoprotein overexpressed in various solid tumours including colorectal and glioblastomas...
  5. Horst D, Kriegl L, Engel J, Kirchner T, Jung A. CD133 expression is an independent prognostic marker for low survival in colorectal cancer. Br J Cancer. 2008;99:1285-9 pubmed publisher
    Colon cancer cells have previously been demonstrated to contain a subpopulation of CD133+ tumour cells that have the ability to initiate tumour growth and are thus referred to as colon cancer-initiating cells or colon cancer stem cells (..
  6. Michaelides M, Johnson S, Poulson A, Bradshaw K, Bellmann C, Hunt D, et al. An autosomal dominant bull's-eye macular dystrophy (MCDR2) that maps to the short arm of chromosome 4. Invest Ophthalmol Vis Sci. 2003;44:1657-62 pubmed
    ..A new locus was identified for a bull's-eye macular dystrophy on the short arm of chromosome 4. ..
  7. Gaiser T, Camps J, Meinhardt S, Wangsa D, Nguyen Q, Varma S, et al. Genome and transcriptome profiles of CD133-positive colorectal cancer cells. Am J Pathol. 2011;178:1478-88 pubmed publisher
    ..might be organized hierarchically and contain a subpopulation of tumorigenic, putative cancer stem cells that are CD133 positive. We studied the biological and genetic characteristics of such cells in CRC cell lines and primary tumors...
  8. Kemper K, Versloot M, Cameron K, Colak S, De Sousa E Melo F, de Jong J, et al. Mutations in the Ras-Raf Axis underlie the prognostic value of CD133 in colorectal cancer. Clin Cancer Res. 2012;18:3132-41 pubmed publisher
    High expression of cancer stem cell (CSC) marker CD133 has been used as a predictor for prognosis in colorectal cancer (CRC), suggesting that enumeration of CSCs, using CD133, is predictive for disease progression...
  9. Friel A, Zhang L, Curley M, Therrien V, Sergent P, Belden S, et al. Epigenetic regulation of CD133 and tumorigenicity of CD133 positive and negative endometrial cancer cells. Reprod Biol Endocrinol. 2010;8:147 pubmed publisher
    ..b>CD133, a cell surface marker expressed on primitive cells of neural, hematopoietic, endothelial and epithelial lineages ..

More Information

Publications143 found, 100 shown here

  1. Tabu K, Kimura T, Sasai K, Wang L, Bizen N, Nishihara H, et al. Analysis of an alternative human CD133 promoter reveals the implication of Ras/ERK pathway in tumor stem-like hallmarks. Mol Cancer. 2010;9:39 pubmed publisher
    ..b>CD133 has been identified as an important cell surface marker to enrich the stem-like population in various human tumors...
  2. Wang Q, Chen Z, Du C, Wang H, Yan L, Gu J. Cancer stem cell marker CD133+ tumour cells and clinical outcome in rectal cancer. Histopathology. 2009;55:284-93 pubmed publisher
    The CD133 antigen has been identified as a putative stem cell marker in colorectal cancer tissues...
  3. Terry J, Nielsen T. Expression of CD133 in synovial sarcoma. Appl Immunohistochem Mol Morphol. 2010;18:159-65 pubmed publisher
    ..sarcoma that are reminiscent of neural development, suggesting that a neural cancer stem-like cell marker, such as CD133, may mark cancer stem-like cells in synovial sarcoma, allowing for further characterization...
  4. Zhang C, Xu Y, Zhao J, Fan L, Jiang G, Li R, et al. Elevated expression of the stem cell marker CD133 associated with Line-1 demethylation in hepatocellular carcinoma. Ann Surg Oncol. 2011;18:2373-80 pubmed publisher
    The relationship of Line-1 demethylation and the CD133 expression of cancer stem cells were discussed in hepatocellular carcinoma (HCC)...
  5. Coco C, Zannoni G, Caredda E, Sioletic S, Boninsegna A, Migaldi M, et al. Increased expression of CD133 and reduced dystroglycan expression are strong predictors of poor outcome in colon cancer patients. J Exp Clin Cancer Res. 2012;31:71 pubmed publisher
    Expression levels of CD133, a cancer stem cell marker, and of the ?-subunit of the dystroglycan (?-DG) complex, have been previously reported to be altered in colorectal cancers...
  6. Zeppernick F, Ahmadi R, Campos B, Dictus C, Helmke B, Becker N, et al. Stem cell marker CD133 affects clinical outcome in glioma patients. Clin Cancer Res. 2008;14:123-9 pubmed publisher
    The CD133 antigen has been identified as a putative stem cell marker in normal and malignant brain tissues. In gliomas, it is used to enrich a subpopulation of highly tumorigenic cancer cells...
  7. Zhang J, Luo N, Luo Y, Peng Z, Zhang T, Li S. microRNA-150 inhibits human CD133-positive liver cancer stem cells through negative regulation of the transcription factor c-Myb. Int J Oncol. 2012;40:747-56 pubmed publisher
    ..Here, we compared the miRNA profiles of CD133+ and CD133- primary hepatocellular carcinoma (HCC) subpopulations and found upregulation of 5 miRNAs ..
  8. Miraglia S, Godfrey W, Yin A, Atkins K, Warnke R, Holden J, et al. A novel five-transmembrane hematopoietic stem cell antigen: isolation, characterization, and molecular cloning. Blood. 1997;90:5013-21 pubmed
    ..We have recently described the production of AC133, a monoclonal antibody (MoAb) that binds to a novel cell surface antigen present on a CD34(bright) subset of human ..
  9. Sgambato A, Puglisi M, Errico F, Rafanelli F, Boninsegna A, Rettino A, et al. Post-translational modulation of CD133 expression during sodium butyrate-induced differentiation of HT29 human colon cancer cells: implications for its detection. J Cell Physiol. 2010;224:234-41 pubmed publisher
    The CD133 molecule has been proposed as a surface marker of cancer stem cells in several human malignancies, including colon cancers. The function and the mechanisms regulating CD133 expression remain unknown...
  10. Gopisetty G, Xu J, Sampath D, Colman H, Puduvalli V. Epigenetic regulation of CD133/PROM1 expression in glioma stem cells by Sp1/myc and promoter methylation. Oncogene. 2013;32:3119-29 pubmed publisher
    ..cells for malignancies, have been identified in several cancers using cell-surface expression of markers including CD133, a pentaspan membrane protein...
  11. Tabu K, Sasai K, Kimura T, Wang L, Aoyanagi E, Kohsaka S, et al. Promoter hypomethylation regulates CD133 expression in human gliomas. Cell Res. 2008;18:1037-46 pubmed publisher
    Brain tumor-initiating cells (BTICs) have been enriched using antibodies against the cell surface protein CD133; however, the biological relevance and the regulatory mechanism of CD133 expression in human gliomas are not yet understood...
  12. Al Dhaybi R, Sartelet H, Powell J, Kokta V. Expression of CD133+ cancer stem cells in childhood malignant melanoma and its correlation with metastasis. Mod Pathol. 2010;23:376-80 pubmed publisher
    Cancer stem cells expressing CD133 exist in a wide array of tumors and their identification in malignant melanoma may help refine classification, diagnosis and treatment...
  13. Yang Z, Zheng Q, Yan J, Pan Y, Wang Z. Upregulated CD133 expression in tumorigenesis of colon cancer cells. World J Gastroenterol. 2011;17:932-7 pubmed publisher
    To analyze the upregulated CD133 expression in tumorigenesis of primary colon cancer cells...
  14. Zhao P, Lu Y, Jiang X, Li X. Clinicopathological significance and prognostic value of CD133 expression in triple-negative breast carcinoma. Cancer Sci. 2011;102:1107-11 pubmed publisher
    Currently, CD133 is one of the best markers to characterize cancer stem cells and Her-1 is reported as an important marker for the prognosis of triple-negative breast cancer...
  15. Hongo K, Kazama S, Sunami E, Tsuno N, Takahashi K, Nagawa H, et al. Immunohistochemical detection of CD133 is associated with tumor regression grade after chemoradiotherapy in rectal cancer. Med Oncol. 2012;29:2849-57 pubmed publisher
    b>CD133 has been identified as a putative cancer stem cell (CSC) marker in various cancers including colorectal cancer. The relation between CD133 expression and biological characteristics of colorectal cancer remains to be clarified...
  16. Katoh Y, Katoh M. Comparative genomics on PROM1 gene encoding stem cell marker CD133. Int J Mol Med. 2007;19:967-70 pubmed
    ..PROM1 gene encodes CD133 protein, which is a cell surface marker of hematopoietic stem cells, prostatic epithelial stem cells, pancreatic ..
  17. Pras E, Abu A, Rotenstreich Y, Avni I, Reish O, Morad Y, et al. Cone-rod dystrophy and a frameshift mutation in the PROM1 gene. Mol Vis. 2009;15:1709-16 pubmed
    ..1 Mb on chromosome 4p that fully segregates with the disease within the family. This region encompasses the PROML1 gene, mutations of which have been implicated in retinal dystrophies...
  18. Chen S, Song X, Chen Z, Li X, Li M, Liu H, et al. CD133 expression and the prognosis of colorectal cancer: a systematic review and meta-analysis. PLoS ONE. 2013;8:e56380 pubmed publisher
    b>CD133 has recently been reported as a marker of cancer stem-like cells in colorectal cancer (CRC). However, its predictive value in CRC still remains controversial...
  19. Baba T, Convery P, Matsumura N, Whitaker R, Kondoh E, Perry T, et al. Epigenetic regulation of CD133 and tumorigenicity of CD133+ ovarian cancer cells. Oncogene. 2009;28:209-18 pubmed publisher
    ..As the cell surface marker CD133 identifies cancer-initiating cells in a number of other malignancies, we sought to determine the potential role of ..
  20. Bodzin A, Wei Z, Hurtt R, Gu T, Doria C. Gefitinib resistance in HCC mahlavu cells: upregulation of CD133 expression, activation of IGF-1R signaling pathway, and enhancement of IGF-1R nuclear translocation. J Cell Physiol. 2012;227:2947-52 pubmed publisher
    ..In the present study, we examined the expression of cancer stem cell (CSC) marker CD133, the activation of insulin-like growth factor 1 receptor (IGF-1R) signaling, and the nuclear translocation of IGF-..
  21. Jiang Y, He Y, Li H, Li H, Zhang L, Hu W, et al. Expressions of putative cancer stem cell markers ABCB1, ABCG2, and CD133 are correlated with the degree of differentiation of gastric cancer. Gastric Cancer. 2012;15:440-50 pubmed publisher
    ..The present study was carried out to determine whether a quantitative relationship exists between the expressions of 3 cancer stem cell (CSC) markers and the degree of differentiation of gastric cancer...
  22. Saigusa S, Tanaka K, Toiyama Y, Yokoe T, Okugawa Y, Kawamoto A, et al. Immunohistochemical features of CD133 expression: association with resistance to chemoradiotherapy in rectal cancer. Oncol Rep. 2010;24:345-50 pubmed
    b>CD133 has been described as a marker for cancer stem cells (CSCs) in colorectal cancer. Additionally, it has been reported that CSCs are resistant to chemoradiotherapy (CRT)...
  23. Iida H, Suzuki M, Goitsuka R, Ueno H. Hypoxia induces CD133 expression in human lung cancer cells by up-regulation of OCT3/4 and SOX2. Int J Oncol. 2012;40:71-9 pubmed publisher
    b>CD133 has been recognized as a specific cell surface marker for cancer stem cells in various tumors, although its biological functions and transcriptional regulation remain unclear...
  24. Corbo C, Orru S, Gemei M, Noto R, Mirabelli P, Imperlini E, et al. Protein cross-talk in CD133+ colon cancer cells indicates activation of the Wnt pathway and upregulation of SRp20 that is potentially involved in tumorigenicity. Proteomics. 2012;12:2045-59 pubmed publisher
    ..Putative CSCs were separated from non-CSCs by flow cytometry using CD133 as stemness marker...
  25. Zhang H, Wei Y, Wang M, Wu C, Yang Y, Chen J, et al. [Association of CD133 and endothelin-converting enzyme expressions with prognosis of non-small cell lung carcinoma]. Nan Fang Yi Ke Da Xue Xue Bao. 2007;27:696-9 pubmed
    To investigate the expression of tumor stem cell marker CD133 and endothelin-converting enzymes (ECE) in non-small cell lung carcinoma (NSCLC) and their association with NSCLC lymphoid metastasis...
  26. Sartelet H, Imbriglio T, Nyalendo C, Haddad E, Annabi B, Duval M, et al. CD133 expression is associated with poor outcome in neuroblastoma via chemoresistance mediated by the AKT pathway. Histopathology. 2012;60:1144-55 pubmed publisher
    Neuroblastoma is a frequent childhood cancer with a heterogeneous prognosis. CD133 expression is an independent prognostic marker for a low survival rate in several cancers...
  27. Fukamachi H, Shimada S, Ito K, Ito Y, Yuasa Y. CD133 is a marker of gland-forming cells in gastric tumors and Sox17 is involved in its regulation. Cancer Sci. 2011;102:1313-21 pubmed publisher
    b>CD133 is a universal marker of tissue stem/progenitor cells as well as cancer stem cells, but its physiological significance remains to be elucidated...
  28. Dong L, Qi N, Ge R, Cao C, Lan F, Shen L. Overexpression of CD133 promotes the phosphorylation of Erk in U87MG human glioblastoma cells. Neurosci Lett. 2010;484:210-4 pubmed publisher
    ..b>CD133 has been identified as an important cell surface marker to enrich the stem-like population in various human tumors...
  29. Mak A, Nixon A, Kittanakom S, Stewart J, Chen G, Curak J, et al. Regulation of CD133 by HDAC6 promotes ?-catenin signaling to suppress cancer cell differentiation. Cell Rep. 2012;2:951-63 pubmed publisher
    The pentaspan membrane glycoprotein CD133 marks lineage-specific cancer progenitor cells and is associated with poor prognosis in a number of tumor types...
  30. Kojima M, Ishii G, Atsumi N, Fujii S, Saito N, Ochiai A. Immunohistochemical detection of CD133 expression in colorectal cancer: a clinicopathological study. Cancer Sci. 2008;99:1578-83 pubmed publisher
    b>CD133 has been reported to be a cancer-initiating cell marker in colorectal carcinoma...
  31. Curley M, Therrien V, Cummings C, Sergent P, Koulouris C, Friel A, et al. CD133 expression defines a tumor initiating cell population in primary human ovarian cancer. Stem Cells. 2009;27:2875-83 pubmed publisher
    ..of human ovarian tumors for expression of candidate CSC surface markers indicated consistent expression of CD133. To determine whether CD133 expression could define a tumor-initiating cell population in primary human ovarian ..
  32. Lin E, Hassan M, Li Y, Zhao H, Nooka A, Sorenson E, et al. Elevated circulating endothelial progenitor marker CD133 messenger RNA levels predict colon cancer recurrence. Cancer. 2007;110:534-42 pubmed
    b>CD133 is a specific surface marker for bone marrow-derived circulating endothelial progenitors, which are vital in postnatal physiologic and pathologic (eg, tumor) angiogenesis...
  33. Rappa G, Fodstad O, Lorico A. The stem cell-associated antigen CD133 (Prominin-1) is a molecular therapeutic target for metastatic melanoma. Stem Cells. 2008;26:3008-17 pubmed publisher
    b>CD133 (Prominin-1) is considered the most important cancer stem cell (CSC)-associated marker identified so far, with increased expression in the CSC fraction of a large variety of human malignancies, including melanoma...
  34. Bozzi F, Conca E, Manenti G, Negri T, Brich S, Gronchi A, et al. High CD133 expression levels in gastrointestinal stromal tumors. Cytometry B Clin Cytom. 2011;80:238-47 pubmed publisher
    ..we tried to identify putative GIST CSCs by looking for the occurrence of common CSC markers such as KIT, CD133, CD90, CD44, and CD34 in 18 surgical samples obtained from nine untreated and nine imatinib-treated KIT-mutated ..
  35. Li H, Zhao P, Lu Y, Lu Y. Correlation of aberrant expression of CD133 with FHIT and malignant phenotype of colorectal adenocarcinoma. Int J Colorectal Dis. 2012;27:1015-20 pubmed
    The relationship between the expression of CD133 and fragile histidine triad (FHIT) or prognosis in Chinese colorectal adenocarcinoma is unknown and needs to be explored...
  36. Karbanova J, Missol Kolka E, Fonseca A, Lorra C, Janich P, Hollerová H, et al. The stem cell marker CD133 (Prominin-1) is expressed in various human glandular epithelia. J Histochem Cytochem. 2008;56:977-93 pubmed publisher
    ..of prominin-1 in adult human epithelia might be explained, at least in part, by the specificity of the widely used AC133 antibody, which recognizes an epitope that seems dependent on glycosylation...
  37. Ong C, Kim L, Kong H, Low L, Iacopetta B, Soong R, et al. CD133 expression predicts for non-response to chemotherapy in colorectal cancer. Mod Pathol. 2010;23:450-7 pubmed publisher
    ..In this study, immunohistochemistry for three candidate cancer stem cell markers (CD133, Oct-4 and Sox-2) and for six other postulated prognostic markers (CK7, CK20, Cox-2, Ki-67, p27 and p53) were ..
  38. Hang D, Dong H, Ning T, Dong B, Hou D, Xu W. Prognostic value of the stem cell markers CD133 and ABCG2 expression in esophageal squamous cell carcinoma. Dis Esophagus. 2012;25:638-44 pubmed publisher
    ..light of increasing evidence supporting cancer stem cells (CSCs) theory, the expression of two stem cell markers, CD133 and adenosine triphosphate-binding cassette superfamily G member 2 (ABCG2), in esophageal squamous cell carcinoma (..
  39. Huttner H, Corbeil D, Thirmeyer C, Coras R, Kohrmann M, Mauer C, et al. Increased membrane shedding--indicated by an elevation of CD133-enriched membrane particles--into the CSF in partial epilepsy. Epilepsy Res. 2012;99:101-6 pubmed publisher
    ..in addition to soluble proteins also contains membrane particles that moreover carry the somatic stem cell marker CD133. The significance of CD133 as a potential marker of cellular proliferation, including neurogenesis, remains ..
  40. Kemper K, Sprick M, de Bree M, Scopelliti A, Vermeulen L, Hoek M, et al. The AC133 epitope, but not the CD133 protein, is lost upon cancer stem cell differentiation. Cancer Res. 2010;70:719-29 pubmed publisher
    Colon cancer stem cells (CSC) can be identified with AC133, an antibody that detects an epitope on CD133...
  41. Giebel B, Corbeil D, Beckmann J, Höhn J, Freund D, Giesen K, et al. Segregation of lipid raft markers including CD133 in polarized human hematopoietic stem and progenitor cells. Blood. 2004;104:2332-8 pubmed
    ..leukocytes; and (3) redistribute several lipid raft markers including cholesterol-binding protein prominin-1 (CD133) in specialized plasma membrane domains...
  42. O Brien C, Pollett A, Gallinger S, Dick J. A human colon cancer cell capable of initiating tumour growth in immunodeficient mice. Nature. 2007;445:106-10 pubmed
    ..Purification experiments established that all CC-ICs were CD133+; the CD133- cells that comprised the majority of the tumour were unable to initiate tumour growth...
  43. Platet N, Liu S, Atifi M, Oliver L, Vallette F, Berger F, et al. Influence of oxygen tension on CD133 phenotype in human glioma cell cultures. Cancer Lett. 2007;258:286-90 pubmed
    ..We demonstrate, using low-passaged human tumor cell cultures established from glioma, that a reduction in the oxygen level in these cell cultures dramatically increases the percentage of CD133 expressing cells.
  44. Bourseau Guilmain E, Griveau A, Benoit J, Garcion E. The importance of the stem cell marker prominin-1/CD133 in the uptake of transferrin and in iron metabolism in human colon cancer Caco-2 cells. PLoS ONE. 2011;6:e25515 pubmed publisher
    ..Assessed using AC133 monoclonal antibody, CD133 knockdown was shown to improve Alexa488-transferrin (Tf) uptake in Caco-2 cells but had ..
  45. Feng H, Liu Y, Yang L, Bian X, Yang Z, Gu B, et al. Expression of CD133 correlates with differentiation of human colon cancer cells. Cancer Biol Ther. 2010;9:216-23 pubmed
    b>CD133 has been identified as a cancer stem cell marker in colon and several other cancers, but its function is still unknown...
  46. Li F, Zeng H, Ying K. The combination of stem cell markers CD133 and ABCG2 predicts relapse in stage I non-small cell lung carcinomas. Med Oncol. 2011;28:1458-62 pubmed publisher
    The aim of the study was to investigate the expression of two cancer stem cell markers CD133 and ATP-binding cassette superfamily G member 2 (ABCG2) in non-small cell lung carcinomas (NSCLC) and evaluate their prognostic values for ..
  47. Arrigoni F, Matarin M, Thompson P, Michaelides M, McClements M, Redmond E, et al. Extended extraocular phenotype of PROM1 mutation in kindreds with known autosomal dominant macular dystrophy. Eur J Hum Genet. 2011;19:131-7 pubmed publisher
    Mutations in prominin 1 (PROM1) have been shown to result in retinitis pigmentosa, macular degeneration and cone-rod dystrophy...
  48. Wang T, Ong C, Shi J, Srivastava S, Yan B, Cheng C, et al. Sequential expression of putative stem cell markers in gastric carcinogenesis. Br J Cancer. 2011;105:658-65 pubmed publisher
    ..Several biomarkers including CD44, Musashi-1 and CD133 have been reported as putative stem cell (PSC) markers...
  49. Griguer C, Oliva C, Gobin E, Marcorelles P, Benos D, Lancaster J, et al. CD133 is a marker of bioenergetic stress in human glioma. PLoS ONE. 2008;3:e3655 pubmed publisher
    ..Recently, many studies have focused on isolation of brain cancer stem cells using CD133 expression...
  50. Horst D, Kriegl L, Engel J, Kirchner T, Jung A. Prognostic significance of the cancer stem cell markers CD133, CD44, and CD166 in colorectal cancer. Cancer Invest. 2009;27:844-50 pubmed publisher
    b>CD133, CD44, and CD166 are cell surface markers that have recently been associated with colorectal cancer stem cells...
  51. Jaksch M, Múnera J, Bajpai R, Terskikh A, Oshima R. Cell cycle-dependent variation of a CD133 epitope in human embryonic stem cell, colon cancer, and melanoma cell lines. Cancer Res. 2008;68:7882-6 pubmed publisher
    ..Reactivity with an antibody (AC133) to a glycoslyated form of CD133 has been widely used for the enrichment of cells with tumor-initiating activity ..
  52. Fan L, He F, Liu H, Zhu J, Liu Y, Yin Z, et al. CD133: a potential indicator for differentiation and prognosis of human cholangiocarcinoma. BMC Cancer. 2011;11:320 pubmed publisher
    b>CD133 is known to be a cancer stem cell (CSC) marker...
  53. Saigusa S, Tanaka K, Toiyama Y, Yokoe T, Okugawa Y, Koike Y, et al. Clinical significance of CD133 and hypoxia inducible factor-1? gene expression in rectal cancer after preoperative chemoradiotherapy. Clin Oncol (R Coll Radiol). 2011;23:323-32 pubmed publisher
    ..Therefore, we investigated the correlation between the expression of CD133 and hypoxia inducible factor-1? (HIF-1?), and their association with clinical outcome...
  54. Taïeb N, Maresca M, Guo X, Garmy N, Fantini J, Yahi N. The first extracellular domain of the tumour stem cell marker CD133 contains an antigenic ganglioside-binding motif. Cancer Lett. 2009;278:164-173 pubmed publisher
    b>Prominin 1/CD133 is a marker of transplantable cancer stem cells. We have generated anti-peptide antibodies against a N-terminal epitope of CD133 belonging to a ganglioside-binding domain...
  55. Bakondi B, Shimada I, Peterson B, Spees J. SDF-1? secreted by human CD133-derived multipotent stromal cells promotes neural progenitor cell survival through CXCR7. Stem Cells Dev. 2011;20:1021-9 pubmed publisher
    We recently reported that concentrated conditioned medium (CdM) from human CD133-derived bone marrow progenitor cells (CD133 CdM) was neuroprotective after stroke...
  56. Chen Y, Wu M, Huang C, Lin S, Chuang T, Yu C, et al. CD133/Src axis mediates tumor initiating property and epithelial-mesenchymal transition of head and neck cancer. PLoS ONE. 2011;6:e28053 pubmed publisher
    ..Previously, we enriched a subpopulation of head and neck cancer initiating cells (HN-CICs) with up-regulation of CD133 and enhancement of EMT...
  57. Vander Griend D, Karthaus W, Dalrymple S, Meeker A, DeMarzo A, Isaacs J. The role of CD133 in normal human prostate stem cells and malignant cancer-initiating cells. Cancer Res. 2008;68:9703-11 pubmed publisher
    ..When epithelial cell suspensions containing cells expressing the stem cell marker CD133+ are inoculated in vivo, regeneration of stratified human prostate glands requires inductive prostate stromal ..
  58. Salnikov A, Gladkich J, Moldenhauer G, Volm M, Mattern J, Herr I. CD133 is indicative for a resistance phenotype but does not represent a prognostic marker for survival of non-small cell lung cancer patients. Int J Cancer. 2010;126:950-8 pubmed publisher
    ..CSCs found in many solid tumors express CD133 antigen on the cell surface...
  59. Michaelides M, Gaillard M, Escher P, Tiab L, Bedell M, Borruat F, et al. The PROM1 mutation p.R373C causes an autosomal dominant bull's eye maculopathy associated with rod, rod-cone, and macular dystrophy. Invest Ophthalmol Vis Sci. 2010;51:4771-80 pubmed publisher
  60. Huang X, Sheng Y, Guan M. Co-expression of stem cell genes CD133 and CD44 in colorectal cancers with early liver metastasis. Surg Oncol. 2012;21:103-7 pubmed publisher
    To investigate the expression status and clinical implications of stem cell genes CD133 and CD44 in the colorectal cancers with early liver metastasis...
  61. Pohl A, El Khoueiry A, Yang D, Zhang W, Lurje G, Ning Y, et al. Pharmacogenetic profiling of CD133 is associated with response rate (RR) and progression-free survival (PFS) in patients with metastatic colorectal cancer (mCRC), treated with bevacizumab-based chemotherapy. Pharmacogenomics J. 2013;13:173-80 pubmed publisher
    Recent studies suggest CD133, a surface protein widely used for isolation of colon cancer stem cells, to be associated with tumor angiogenesis and recurrence...
  62. Tong Q, Zheng L, Tang S, Ruan Q, Liu Y, Li S, et al. Expression and clinical significance of stem cell marker CD133 in human neuroblastoma. World J Pediatr. 2008;4:58-62 pubmed publisher
    Recent evidences indicate that CD133, a kind of transmembrane protein, can be used as a marker to isolate stem cells from tumors originating from neural crest...
  63. Chen J, Guo T, Zhang L, Qin L, Singer S, Maki R, et al. CD133 and CD44 are universally overexpressed in GIST and do not represent cancer stem cell markers. Genes Chromosomes Cancer. 2012;51:186-95 pubmed publisher
    ..study was aimed to determine whether expression of commonly used stem cell markers in other malignancies, that is, CD133 and CD44, might identify cells with characteristics of cancer stem/progenitor cells in human GIST...
  64. Herpel E, Jensen K, Muley T, Warth A, Schnabel P, Meister M, et al. The cancer stem cell antigens CD133, BCRP1/ABCG2 and CD117/c-KIT are not associated with prognosis in resected early-stage non-small cell lung cancer. Anticancer Res. 2011;31:4491-500 pubmed
    ..In various tumor entities, expression of cancer stem cell (CSC) antigens has been proven to be prognostically unfavorable. However, for lung cancer, the data are scant and conflicting...
  65. Barcelos L, Duplaa C, Krankel N, Graiani G, Invernici G, Katare R, et al. Human CD133+ progenitor cells promote the healing of diabetic ischemic ulcers by paracrine stimulation of angiogenesis and activation of Wnt signaling. Circ Res. 2009;104:1095-102 pubmed publisher
    We evaluated the healing potential of human fetal aorta-derived CD133(+) progenitor cells and their conditioned medium (CD133(+) CCM) in a new model of ischemic diabetic ulcer...
  66. Hibi K, Sakata M, Sakuraba K, Shirahata A, Goto T, Mizukami H, et al. CD133 gene overexpression is frequently observed in early colorectal carcinoma. Hepatogastroenterology. 2009;56:995-7 pubmed
    ..been proved that colorectal carcinoma is created and propagated by a small number of undifferentiated tumorigenic CD133+ cells. The present study examined the CD133 gene expression in colorectal carcinomas we surgically removed...
  67. Horn P, Tesch H, Staib P, Kube D, Diehl V, Voliotis D. Expression of AC133, a novel hematopoietic precursor antigen, on acute myeloid leukemia cells. Blood. 1999;93:1435-7 pubmed
  68. Hibi K, Sakata M, Kitamura Y, Sakuraba K, Shirahata A, Goto T, et al. Demethylation of the CD133 gene is frequently detected in early gastric carcinoma. Anticancer Res. 2010;30:1201-3 pubmed
    ..reported that colorectal carcinoma is created and propagated by a small number of undifferentiated tumorigenic CD133(+) cells...
  69. Yan X, Ma L, Yi D, Yoon J, Diercks A, Foltz G, et al. A CD133-related gene expression signature identifies an aggressive glioblastoma subtype with excessive mutations. Proc Natl Acad Sci U S A. 2011;108:1591-6 pubmed publisher
    ..The transmembrane protein CD133 has been widely used to isolate putative CSC populations in several cancer types, but its validity as a CSC marker ..
  70. Maw M, Corbeil D, Koch J, Hellwig A, Wilson Wheeler J, Bridges R, et al. A frameshift mutation in prominin (mouse)-like 1 causes human retinal degeneration. Hum Mol Genet. 2000;9:27-34 pubmed
    ..One such candidate is the gene encoding human prominin (mouse)-like 1 (PROML1, previously known as AC133 antigen) which belongs to the prominin family of 5-transmembrane domain proteins...
  71. Ma S, Chan K, Lee T, Tang K, Wo J, Zheng B, et al. Aldehyde dehydrogenase discriminates the CD133 liver cancer stem cell populations. Mol Cancer Res. 2008;6:1146-53 pubmed publisher
    ..in our study of cancer stem cells (CSC) in hepatocellular carcinoma (HCC) have led to the identification of CD133 as a prominent HCC CSC marker...
  72. Okudela K, Woo T, Mitsui H, Tajiri M, Masuda M, Ohashi K. Expression of the potential cancer stem cell markers, CD133, CD44, ALDH1, and ?-catenin, in primary lung adenocarcinoma--their prognostic significance. Pathol Int. 2012;62:792-801 pubmed publisher
    The present study investigated expression profiles of the potential CSC markers including CD133, CD44, ALDH1, and ?-catenin, and evaluated their prognostic value in lung adenocarcinomas...
  73. Wen L, Chen X, Yang K, Chen Z, Zhang B, Chen J, et al. Prognostic value of cancer stem cell marker CD133 expression in gastric cancer: a systematic review. PLoS ONE. 2013;8:e59154 pubmed publisher
    ..the Medline and Chinese CNKI (up to 1 Dec 2011) was performed using the following keywords gastric cancer, CD133, AC133, prominin-1 etc...
  74. Wei X, Zhou L, Cheng L, Tian J, Jiang J, Maccallum J. In vivo investigation of CD133 as a putative marker of cancer stem cells in Hep-2 cell line. Head Neck. 2009;31:94-101 pubmed publisher
    ..Our in vitro experiment shown as CD133, a 5-transmembrane glycoprotein expressed in Hep-2 cell line...
  75. Permanyer J, Navarro R, Friedman J, Pomares E, Castro Navarro J, Marfany G, et al. Autosomal recessive retinitis pigmentosa with early macular affectation caused by premature truncation in PROM1. Invest Ophthalmol Vis Sci. 2010;51:2656-63 pubmed publisher
  76. Zhang Q, Zulfiqar F, Xiao X, Riazuddin S, Ahmad Z, Caruso R, et al. Severe retinitis pigmentosa mapped to 4p15 and associated with a novel mutation in the PROM1 gene. Hum Genet. 2007;122:293-9 pubmed
    ..The mutation was not detected in 192 chromosomes of unrelated control individuals of the same ethnicity and from the same region. This delineates the phenotypic characteristics of retinopathy caused by mutations in PROM1. ..
  77. Huttner H, Janich P, Kohrmann M, Jászai J, Siebzehnrubl F, Blumcke I, et al. The stem cell marker prominin-1/CD133 on membrane particles in human cerebrospinal fluid offers novel approaches for studying central nervous system disease. Stem Cells. 2008;26:698-705 pubmed
    ..Here, we show that human CSF contains specific membrane particles that carry prominin-1/CD133, a neural stem cell marker implicated in brain tumors, notably glioblastoma...
  78. Shepherd C, Rizzo S, Ledaki I, Davies M, Brewer D, Attard G, et al. Expression profiling of CD133+ and CD133- epithelial cells from human prostate. Prostate. 2008;68:1007-24 pubmed publisher
    Recent evidence suggests that prostate stem cells in benign and tumor tissue express the cell surface marker CD133, but these cells have not been well characterized...
  79. Shimada M, Sugimoto K, Iwahashi S, Utsunomiya T, Morine Y, Imura S, et al. CD133 expression is a potential prognostic indicator in intrahepatic cholangiocarcinoma. J Gastroenterol. 2010;45:896-902 pubmed publisher
    b>CD133 is one of the most important cancer-initiating (stem) cell markers and was confirmed to be expressed in solid cancers such as colon cancer...
  80. Arne G, Kristiansson E, Nerman O, Kindblom L, Ahlman H, Nilsson B, et al. Expression profiling of GIST: CD133 is associated with KIT exon 11 mutations, gastric location and poor prognosis. Int J Cancer. 2011;129:1149-61 pubmed publisher
    ..In addition, gene expression profiles for 35 GISTs were analyzed by meta-analysis. Expression of CD133 (prominin-1) protein was examined by tissue microarray (TMA) analysis of 204 GISTs from a population-based study ..
  81. Yu Y, Flint A, Dvorin E, Bischoff J. AC133-2, a novel isoform of human AC133 stem cell antigen. J Biol Chem. 2002;277:20711-6 pubmed
    Human AC133 antigen, also called CD133, was recently identified as a hematopoietic stem cell marker. However, the molecular structure and function of this protein has remained unclear...
  82. Sagrinati C, Netti G, Mazzinghi B, Lazzeri E, Liotta F, Frosali F, et al. Isolation and characterization of multipotent progenitor cells from the Bowman's capsule of adult human kidneys. J Am Soc Nephrol. 2006;17:2443-56 pubmed
    ..of parietal epithelial cells (PEC) in the Bowman's capsule exhibit coexpression of the stem cell markers CD24 and CD133 and of the stem cell-specific transcription factors Oct-4 and BmI-1, in the absence of lineage-specific markers...
  83. Rebetz J, Tian D, Persson A, Widegren B, Salford L, Englund E, et al. Glial progenitor-like phenotype in low-grade glioma and enhanced CD133-expression and neuronal lineage differentiation potential in high-grade glioma. PLoS ONE. 2008;3:e1936 pubmed publisher
    ..and 17 high-grade glioma specimens were flow-cytometrically analyzed for markers characteristics of stem cells (CD133); glial progenitors (PDGFRalpha, A2B5, O4, and CD44); and late oligodendrocyte progenitors (O1)...
  84. Puglisi M, Barba M, Corbi M, Errico M, Giorda E, Saulnier N, et al. Identification of Endothelin-1 and NR4A2 as CD133-regulated genes in colon cancer cells. J Pathol. 2011;225:305-14 pubmed publisher
    ..b>CD133 antigen has been proposed as a CSC marker in colon cancer (CC)...
  85. Aomatsu N, Yashiro M, Kashiwagi S, Takashima T, Ishikawa T, Ohsawa M, et al. CD133 is a useful surrogate marker for predicting chemosensitivity to neoadjuvant chemotherapy in breast cancer. PLoS ONE. 2012;7:e45865 pubmed publisher
    ..We hypothesized that a cancer stem cell marker may identify NAC-resistant patients, and evaluated CD133 and ALDH1 as a potential surrogate marker for breast cancer...
  86. Wang K, Xu J, Zhang J, Huang J. Prognostic role of CD133 expression in colorectal cancer: a meta-analysis. BMC Cancer. 2012;12:573 pubmed publisher
    b>CD133 has been identified as a putative cancer stem cell marker in colorectal cancer (CRC). However, the clinical and prognostic significance of CD133 in CRC remains controversial...
  87. Bertolini G, Roz L, Perego P, Tortoreto M, Fontanella E, Gatti L, et al. Highly tumorigenic lung cancer CD133+ cells display stem-like features and are spared by cisplatin treatment. Proc Natl Acad Sci U S A. 2009;106:16281-6 pubmed publisher
    ..b>CD133, a surface glycoprotein linked to organ-specific stem cells, was described as a marker of cancer-initiating cells ..
  88. Elsaba T, Martinez Pomares L, Robins A, Crook S, Seth R, Jackson D, et al. The stem cell marker CD133 associates with enhanced colony formation and cell motility in colorectal cancer. PLoS ONE. 2010;5:e10714 pubmed publisher
    b>CD133 is a membrane molecule that has been, controversially, reported as a CSC marker in colorectal cancer (CRC). In this study, we sought to clarify the expression and role of CD133 in CRC...
  89. Wang Y, Zhu Y, Qiu F, Zhang T, Chen Z, Zheng S, et al. Activation of Akt and MAPK pathways enhances the tumorigenicity of CD133+ primary colon cancer cells. Carcinogenesis. 2010;31:1376-80 pubmed publisher
    ..However, the molecular mechanism of CSC involved in these events needs to be further elucidated. In this study, CD133(+) colon cancer cells were cultured, which showed CSC properties both in vitro and in vivo from metastatic tissue...
  90. Li G, Liu C, Yuan J, Xiao X, Tang N, Hao J, et al. CD133(+) single cell-derived progenies of colorectal cancer cell line SW480 with different invasive and metastatic potential. Clin Exp Metastasis. 2010;27:517-27 pubmed publisher
    ..b>CD133 (Prominin-1, Prom1) is the marker of human colorectal cancer (CRC) stem cells and probably a marker of metastatic ..
  91. Missol Kolka E, Karbanova J, Janich P, Haase M, Fargeas C, Huttner W, et al. Prominin-1 (CD133) is not restricted to stem cells located in the basal compartment of murine and human prostate. Prostate. 2011;71:254-67 pubmed publisher
    ..A report has shown that human PROMININ-1 carrying the AC133 epitope can be used to identify rare prostate basal stem cells (Richardson et al...
  92. Wei Y, Jiang Y, Zou F, Liu Y, Wang S, Xu N, et al. Activation of PI3K/Akt pathway by CD133-p85 interaction promotes tumorigenic capacity of glioma stem cells. Proc Natl Acad Sci U S A. 2013;110:6829-34 pubmed publisher
    The biological significance of a known normal and cancer stem cell marker CD133 remains elusive...