CAR

Summary

Gene Symbol: CAR
Description: CXADR, Ig-like cell adhesion molecule
Alias: CAR, CAR4/6, HCAR, coxsackievirus and adenovirus receptor, 46 kD coxsackievirus and adenovirus receptor (CAR) protein, CVB3-binding protein, HCVADR, coxsackie virus and adenovirus receptor, coxsackievirus B-adenovirus receptor
Species: human
Products:     CAR

Top Publications

  1. Tomko R, Johansson C, Totrov M, Abagyan R, Frisen J, Philipson L. Expression of the adenovirus receptor and its interaction with the fiber knob. Exp Cell Res. 2000;255:47-55 pubmed
    The coxsackievirus group B (CVB) and adenovirus (Ad) receptor (HCVADR, formerly HCAR) is a cell surface protein with two immunoglobulin-like regions (IG1 and IG2) that serves as a receptor for two structurally unrelated viruses...
  2. Zanone M, Favaro E, Ferioli E, Huang G, Klein N, Perin P, et al. Human pancreatic islet endothelial cells express coxsackievirus and adenovirus receptor and are activated by coxsackie B virus infection. FASEB J. 2007;21:3308-17 pubmed
    ..CVB-4 persistently infected the islet MECs, which expressed the CV receptors human coxsackievirus and adenovirus receptor (HCAR) and decay accelerating factor (DAF) and maintained EC characteristics, without overt ..
  3. Excoffon K, Hruska Hageman A, Klotz M, Traver G, Zabner J. A role for the PDZ-binding domain of the coxsackie B virus and adenovirus receptor (CAR) in cell adhesion and growth. J Cell Sci. 2004;117:4401-9 pubmed
    The coxsackie and adenovirus receptor (CAR) plays a role in viral infection, maintenance of the junction adhesion complex in polarized epithelia, and modulation of cellular growth properties...
  4. Carson S, Chapman N, Tracy S. Purification of the putative coxsackievirus B receptor from HeLa cells. Biochem Biophys Res Commun. 1997;233:325-8 pubmed
    ..Identification of 26 amino acid residues in the protein and corresponding GenBank enteries will accelerate study of CVB tropism and the diseases caused by these viruses. ..
  5. Lim B, Xiong D, Dorner A, Youn T, Yung A, Liu T, et al. Coxsackievirus and adenovirus receptor (CAR) mediates atrioventricular-node function and connexin 45 localization in the murine heart. J Clin Invest. 2008;118:2758-70 pubmed publisher
    The coxsackievirus and adenovirus receptor (CAR) is a transmembrane protein that belongs to the family of adhesion molecules. In the postnatal heart, it is localized predominantly at the intercalated disc, where its function is not known...
  6. Fechner H, Haack A, Wang H, Wang X, Eizema K, Pauschinger M, et al. Expression of coxsackie adenovirus receptor and alphav-integrin does not correlate with adenovector targeting in vivo indicating anatomical vector barriers. Gene Ther. 1999;6:1520-35 pubmed
    ..as well as adenovector-mediated gene transfer depends on virus interaction with the Coxsackie adenovirus receptor (CAR) mediating virus attachment to the cell surface, and on interaction with alphavbeta3 and alphavbeta5 integrins ..
  7. Stecker K, Koschel A, Wiedenmann B, Anders M. Loss of Coxsackie and adenovirus receptor downregulates alpha-catenin expression. Br J Cancer. 2009;101:1574-9 pubmed publisher
    The Coxsackie and adenovirus receptor (CAR) has been shown to inhibit cancer cell proliferation, migration, and invasion. The underlying mechanisms, however, are poorly understood...
  8. van Raaij M, Chouin E, van Der Zandt H, Bergelson J, Cusack S. Dimeric structure of the coxsackievirus and adenovirus receptor D1 domain at 1.7 A resolution. Structure. 2000;8:1147-55 pubmed
    The coxsackievirus and adenovirus receptor (CAR) comprises two extracellular immunoglobulin domains, a transmembrane helix and a C-terminal intracellular domain...
  9. Thoelen I, Magnusson C, Tagerud S, Polacek C, Lindberg M, Van Ranst M. Identification of alternative splice products encoded by the human coxsackie-adenovirus receptor gene. Biochem Biophys Res Commun. 2001;287:216-22 pubmed
    The human cellular receptor for group B coxsackieviruses and adenoviruses (HCAR) is a transmembrane glycoprotein which belongs to the immunoglobulin superfamily...

More Information

Publications73

  1. Cohen C, Shieh J, Pickles R, Okegawa T, Hsieh J, Bergelson J. The coxsackievirus and adenovirus receptor is a transmembrane component of the tight junction. Proc Natl Acad Sci U S A. 2001;98:15191-6 pubmed
    The coxsackievirus and adenovirus receptor (CAR) mediates viral attachment and infection, but its physiologic functions have not been described...
  2. Stecker K, Vieth M, Koschel A, Wiedenmann B, Rocken C, Anders M. Impact of the coxsackievirus and adenovirus receptor on the adenoma-carcinoma sequence of colon cancer. Br J Cancer. 2011;104:1426-33 pubmed publisher
    Coxsackie and adenovirus receptor (CAR) has been suggested to function as a tumour suppressor. Its impact on the adenoma-carcinoma sequence of the colon, however, is unclear...
  3. Gu W, Ogose A, Ito M, Ito T, Matsuba A, Kitahara H, et al. High-level expression of the coxsackievirus and adenovirus receptor messenger RNA in osteosarcoma, Ewing's sarcoma, and benign neurogenic tumors among musculoskeletal tumors. Clin Cancer Res. 2004;10:3831-8 pubmed
    ..tumor tissues to infection with recombinant adenoviruses correlates with the expression of the coxsackievirus and adenovirus receptor (CAR)...
  4. Shaw C, Holland P, Sinnreich M, Allen C, Sollerbrant K, Karpati G, et al. Isoform-specific expression of the Coxsackie and adenovirus receptor (CAR) in neuromuscular junction and cardiac intercalated discs. BMC Cell Biol. 2004;5:42 pubmed
    The Coxsackie and adenovirus receptor (CAR) has a restricted expression pattern in the adult. In skeletal muscle, although CAR is expressed in immature fibers, its transcript levels are barely detectable in mature muscle...
  5. Excoffon K, Gansemer N, Mobily M, Karp P, Parekh K, Zabner J. Isoform-specific regulation and localization of the coxsackie and adenovirus receptor in human airway epithelia. PLoS ONE. 2010;5:e9909 pubmed publisher
    ..Adenovirus fiber from most serotypes co-opts the Coxsackie-Adenovirus Receptor (CAR) to bind and enter cells...
  6. Verdino P, Witherden D, Havran W, Wilson I. The molecular interaction of CAR and JAML recruits the central cell signal transducer PI3K. Science. 2010;329:1210-4 pubmed publisher
    Coxsackie and adenovirus receptor (CAR) is the primary cellular receptor for group B coxsackieviruses and most adenovirus serotypes and plays a crucial role in adenoviral gene therapy...
  7. Küster K, Koschel A, Rohwer N, Fischer A, Wiedenmann B, Anders M. Downregulation of the coxsackie and adenovirus receptor in cancer cells by hypoxia depends on HIF-1alpha. Cancer Gene Ther. 2010;17:141-6 pubmed publisher
    Loss of the coxsackie and adenovirus receptor (CAR) has been found in various human cancers. Underlying mechanisms, however, are still poorly understood...
  8. Walters R, Freimuth P, Moninger T, Ganske I, Zabner J, Welsh M. Adenovirus fiber disrupts CAR-mediated intercellular adhesion allowing virus escape. Cell. 2002;110:789-99 pubmed
    Adenovirus binds its receptor (CAR), enters cells, and replicates. It must then escape to the environment to infect a new host...
  9. Excoffon K, Traver G, Zabner J. The role of the extracellular domain in the biology of the coxsackievirus and adenovirus receptor. Am J Respir Cell Mol Biol. 2005;32:498-503 pubmed
    The Coxsackievirus B and Adenovirus Receptor (CAR) plays a dual role as a homotypic junctional adhesion protein and as a viral receptor...
  10. Chen Z, Wang Q, Sun J, Gu A, Jin M, Shen Z, et al. Expression of the coxsackie and adenovirus receptor in human lung cancers. Tumour Biol. 2013;34:17-24 pubmed publisher
    The aim of this study is to elucidate the relation between expression of coxsackie and adenovirus receptor (CAR) and formation of lung cancer...
  11. Bewley M, Springer K, Zhang Y, Freimuth P, Flanagan J. Structural analysis of the mechanism of adenovirus binding to its human cellular receptor, CAR. Science. 1999;286:1579-83 pubmed
    ..fiber knob domain in complex with domain I of its human cellular receptor, coxsackie and adenovirus receptor (CAR), is presented here. Surface-exposed loops on knob contact one face of CAR, forming a high-affinity complex...
  12. Tomko R, Xu R, Philipson L. HCAR and MCAR: the human and mouse cellular receptors for subgroup C adenoviruses and group B coxsackieviruses. Proc Natl Acad Sci U S A. 1997;94:3352-6 pubmed
    ..We now describe the isolation of cDNAs from human and mouse that encode the human CVB and Ad2 and 5 receptor (HCAR) and the mouse CVB Ad2 and 5 receptor (MCAR)...
  13. Short J, Pereboev A, Kawakami Y, Vasu C, Holterman M, Curiel D. Adenovirus serotype 3 utilizes CD80 (B7.1) and CD86 (B7.2) as cellular attachment receptors. Virology. 2004;322:349-59 pubmed
    ..This finding suggests a mechanism whereby viral exploitation of these proteins as receptors may achieve both goals of cellular entry and evading the immune system. ..
  14. Brüning A, Stickeler E, Diederich D, Walz L, Rohleder H, Friese K, et al. Coxsackie and adenovirus receptor promotes adenocarcinoma cell survival and is expressionally activated after transition from preneoplastic precursor lesions to invasive adenocarcinomas. Clin Cancer Res. 2005;11:4316-20 pubmed
    The cell adhesion protein, coxsackie and adenovirus receptor (CAR), is differentially expressed in various human adenocarcinomas...
  15. Veena M, Qin M, Andersson A, Sharma S, Batra R. CAR mediates efficient tumor engraftment of mesenchymal type lung cancer cells. Lab Invest. 2009;89:875-86 pubmed publisher
    The coxsackie-adenovirus receptor (CAR) is a developmentally regulated intercellular adhesion molecule that was previously observed to be required for efficient tumor formation...
  16. Vigl B, Zgraggen C, Rehman N, Banziger Tobler N, Detmar M, Halin C. Coxsackie- and adenovirus receptor (CAR) is expressed in lymphatic vessels in human skin and affects lymphatic endothelial cell function in vitro. Exp Cell Res. 2009;315:336-47 pubmed publisher
    ..Performing comparative gene expression analysis we have recently found that coxsackie- and adenovirus receptor (CAR) is significantly more highly expressed in cultured human, skin-derived lymphatic endothelial cells (LECs), as ..
  17. Dietel M, Häfner N, Jansen L, Dürst M, Runnebaum I. Novel splice variant CAR 4/6 of the coxsackie adenovirus receptor is differentially expressed in cervical carcinogenesis. J Mol Med (Berl). 2011;89:621-30 pubmed publisher
    The coxsackie adenovirus receptor (CAR) is a component of the tight junction complex and involved in cell adhesion...
  18. Coyne C, Voelker T, Pichla S, Bergelson J. The coxsackievirus and adenovirus receptor interacts with the multi-PDZ domain protein-1 (MUPP-1) within the tight junction. J Biol Chem. 2004;279:48079-84 pubmed
    The coxsackievirus and adenovirus receptor (CAR) is a component of the epithelial cell tight junction. In a yeast two-hybrid screen we identified the multi-PDZ domain protein MUPP1 as an interaction partner for the CAR cytoplasmic domain...
  19. Seiradake E, Lortat Jacob H, Billet O, Kremer E, Cusack S. Structural and mutational analysis of human Ad37 and canine adenovirus 2 fiber heads in complex with the D1 domain of coxsackie and adenovirus receptor. J Biol Chem. 2006;281:33704-16 pubmed
    Adenovirus fibers from most serotypes bind the D1 domain of coxsackie and adenovirus receptor (CAR), although the binding residues are not strictly conserved...
  20. Auer D, Reimer D, Porto V, Fleischer M, Roessler J, Wiedemair A, et al. Expression of coxsackie-adenovirus receptor is related to estrogen sensitivity in breast cancer. Breast Cancer Res Treat. 2009;116:103-11 pubmed publisher
    ..Expression of transmembrane CAR (hCAR) highly correlated with estrogen receptivity, but was independent of the expression of progesterone receptor (PR)...
  21. Bergelson J, Krithivas A, Celi L, Droguett G, Horwitz M, Wickham T, et al. The murine CAR homolog is a receptor for coxsackie B viruses and adenoviruses. J Virol. 1998;72:415-9 pubmed
    Complementary DNA clones encoding the murine homolog (mCAR) of the human coxsackievirus and adenovirus receptor (CAR) were isolated...
  22. Bowles K, Gibson J, Wu J, Shaffer L, Towbin J, Bowles N. Genomic organization and chromosomal localization of the human Coxsackievirus B-adenovirus receptor gene. Hum Genet. 1999;105:354-9 pubmed
    ..The recent description of the common human Coxsackievirus B-adenovirus receptor (CAR) offers at least a partial explanation...
  23. Bergelson J, Cunningham J, Droguett G, Kurt Jones E, Krithivas A, Hong J, et al. Isolation of a common receptor for Coxsackie B viruses and adenoviruses 2 and 5. Science. 1997;275:1320-3 pubmed
    A complementary DNA clone has been isolated that encodes a coxsackievirus and adenovirus receptor (CAR)...
  24. Seiradake E, Henaff D, Wodrich H, Billet O, Perreau M, Hippert C, et al. The cell adhesion molecule "CAR" and sialic acid on human erythrocytes influence adenovirus in vivo biodistribution. PLoS Pathog. 2009;5:e1000277 pubmed publisher
    ..three factors: electrostatic interactions, sialic acid binding and, unexpectedly, binding to the coxsackievirus and adenovirus receptor (CAR) on human erythrocytes...
  25. Cohen C, Gaetz J, Ohman T, Bergelson J. Multiple regions within the coxsackievirus and adenovirus receptor cytoplasmic domain are required for basolateral sorting. J Biol Chem. 2001;276:25392-8 pubmed
    The coxsackievirus and adenovirus receptor (CAR) mediates attachment and infection by coxsackie B viruses and many adenoviruses...
  26. Zen K, Liu Y, McCall I, Wu T, Lee W, Babbin B, et al. Neutrophil migration across tight junctions is mediated by adhesive interactions between epithelial coxsackie and adenovirus receptor and a junctional adhesion molecule-like protein on neutrophils. Mol Biol Cell. 2005;16:2694-703 pubmed
    ..protein (JAML) regulates transmigration via binding interactions with epithelial coxsackie and adenovirus receptor (CAR)...
  27. Sollerbrant K, Raschperger E, Mirza M, Engstrom U, Philipson L, Ljungdahl P, et al. The Coxsackievirus and adenovirus receptor (CAR) forms a complex with the PDZ domain-containing protein ligand-of-numb protein-X (LNX). J Biol Chem. 2003;278:7439-44 pubmed
    The Coxsackievirus and adenovirus receptor (CAR) functions as a virus receptor, but its primary biological function is unknown...
  28. Dorner A, Xiong D, Couch K, Yajima T, Knowlton K. Alternatively spliced soluble coxsackie-adenovirus receptors inhibit coxsackievirus infection. J Biol Chem. 2004;279:18497-503 pubmed
    The coxsackie-adenovirus receptor (CAR) is a transmembrane receptor of the immunoglobulin superfamily whose expression is altered in myocardial and malignant diseases...
  29. Farmer C, Morton P, Snippe M, Santis G, Parsons M. Coxsackie adenovirus receptor (CAR) regulates integrin function through activation of p44/42 MAPK. Exp Cell Res. 2009;315:2637-47 pubmed publisher
    The coxsackie B virus and adenovirus receptor (CAR) is an attachment receptor for Adenovirus serotype 5 (Ad5) and in many cell types forms homodimers with neighbouring cells as part of a cell adhesion complex...
  30. Anders M, Vieth M, Rocken C, Ebert M, Pross M, Gretschel S, et al. Loss of the coxsackie and adenovirus receptor contributes to gastric cancer progression. Br J Cancer. 2009;100:352-9 pubmed publisher
    Loss of the coxsackie and adenovirus receptor (CAR) has previously been observed in gastric cancer. The role of CAR in gastric cancer pathobiology, however, is unclear...
  31. Anders M, Rosch T, Küster K, Becker I, Hofler H, Stein H, et al. Expression and function of the coxsackie and adenovirus receptor in Barrett's esophagus and associated neoplasia. Cancer Gene Ther. 2009;16:508-15 pubmed publisher
    Cell surface presence of the coxsackie and adenovirus receptor (CAR) is considered a crucial prerequisite for the uptake of attenuated adenovirus...
  32. Hussain F, Morton P, Snippe M, Sullivan J, Farmer C, Martin Fernandez M, et al. CAR modulates E-cadherin dynamics in the presence of adenovirus type 5. PLoS ONE. 2011;6:e23056 pubmed publisher
    Adenovirus (Ad) serotype 5 (Ad5) fiber competitively binds to the coxsackievirus and Ad receptor (CAR) to attach Ad5 to target cells and also disrupts cell junctions and facilitates virus escape at a late stage in Ad5 infection...
  33. Fok P, Huang K, Holland P, Nalbantoglu J. The Coxsackie and adenovirus receptor binds microtubules and plays a role in cell migration. J Biol Chem. 2007;282:7512-21 pubmed
    The Coxsackie and adenovirus receptor (CAR), a cell adhesion molecule of the immunoglobulin superfamily, inhibits cell growth of a variety of tumors...
  34. Zhang L, He D, Li X, Li L, Zhu G, Zhang D, et al. Overexpression of coxsackie and adenovirus receptor inhibit growth of human bladder cancer cell in vitro and in vivo. Acta Pharmacol Sin. 2007;28:895-900 pubmed
    To study the effect of the overexpression of coxsackie and the adenovirus receptor (CAR) on the growth of the human bladder cancer cell in vitro and in vivo...
  35. Reimer D, Steppan I, Wiedemair A, Concin N, Hofstetter G, Marth C, et al. Soluble isoforms but not the transmembrane form of coxsackie-adenovirus receptor are of clinical relevance in epithelial ovarian cancer. Int J Cancer. 2007;120:2568-75 pubmed
    The coxsackie-adenovirus receptor (hCAR) has been extensively studied in context of adenoviral-based gene therapy for cancer...
  36. Martin T, Watkins G, Jiang W. The Coxsackie-adenovirus receptor has elevated expression in human breast cancer. Clin Exp Med. 2005;5:122-8 pubmed
    The Coxsackie-adenovirus receptor (CAR) is the primary site for adenovirus attachment during infection and has been used as a delivery mechanism for gene therapies...
  37. VAN T HOF W, Crystal R. Fatty acid modification of the coxsackievirus and adenovirus receptor. J Virol. 2002;76:6382-6 pubmed
    Membrane-proximal cysteines 259 and 260 in the cytoplasmic tail of the coxsackievirus and adenovirus receptor (CAR) are known to be essential for the tumor suppression activity of CAR...
  38. Giaginis C, Zarros A, Papaefthymiou M, Papadopouli A, Sfiniadakis I, Theocharis S. Coxsackievirus and adenovirus receptor expression in human endometrial adenocarcinoma: possible clinical implications. World J Surg Oncol. 2008;6:59 pubmed publisher
    The coxsackievirus and adenovirus receptor (CAR) is a crucial receptor for the entry of both coxsackie B viruses and adenoviruses into host cells...
  39. Wang Y, Wang S, Bao Y, Ni C, Guan N, Zhao J, et al. Coxsackievirus and adenovirus receptor expression in non-malignant lung tissues and clinical lung cancers. J Mol Histol. 2006;37:153-60 pubmed
    ..The expression of coxsackievirus adenovirus receptor (CAR), the primary receptor for the most commonly used adenovirus serotype 5 (Ad5)-based vectors, predominantly ..
  40. Pong R, Roark R, Ou J, Fan J, Stanfield J, Frenkel E, et al. Mechanism of increased coxsackie and adenovirus receptor gene expression and adenovirus uptake by phytoestrogen and histone deacetylase inhibitor in human bladder cancer cells and the potential clinical application. Cancer Res. 2006;66:8822-8 pubmed
    Coxsackie and adenovirus receptor (CAR) is known as a principal receptor for adenovirus commonly used as a gene delivery vector. Down-regulation of CAR is often detected in several cancer types...
  41. Lacher M, Shiina M, Chang P, Keller D, Tiirikainen M, Korn W. ZEB1 limits adenoviral infectability by transcriptionally repressing the coxsackie virus and adenovirus receptor. Mol Cancer. 2011;10:91 pubmed publisher
    ..2006 Feb 1;66(3):1648-57) signaling negatively regulate coxsackie virus and adenovirus receptor (CAR) cell-surface expression and adenovirus uptake...
  42. Carson S. Receptor for the group B coxsackieviruses and adenoviruses: CAR. Rev Med Virol. 2001;11:219-26 pubmed
    Considerable progress towards the characterisation of the long-sought receptor, CAR (coxsackievirus and adenovirus receptor), shared by group B coxsackieviruses (CVB) and most adenoviruses (Ad) has been made since it was isolated and ..
  43. Moog Lutz C, Cavé Riant F, Guibal F, Breau M, Di Gioia Y, Couraud P, et al. JAML, a novel protein with characteristics of a junctional adhesion molecule, is induced during differentiation of myeloid leukemia cells. Blood. 2003;102:3371-8 pubmed
    ..Altogether, our results point to JAML as a novel member of the JAM family expressed on leukocytes with a possible role in leukocyte transmigration. ..
  44. Shetty P, Tang H, Tayo B, Morrison A, Hanis C, Rao D, et al. Variants in CXADR and F2RL1 are associated with blood pressure and obesity in African-Americans in regions identified through admixture mapping. J Hypertens. 2012;30:1970-6 pubmed
    ..This study suggests that CXADR and F2RL1 likely play important roles in BP and obesity variation, respectively; and these findings are consistent with those of other studies, so replication and functional analyses are necessary. ..
  45. Milstone A, Petrella J, Sanchez M, Mahmud M, Whitbeck J, Bergelson J. Interaction with coxsackievirus and adenovirus receptor, but not with decay-accelerating factor (DAF), induces A-particle formation in a DAF-binding coxsackievirus B3 isolate. J Virol. 2005;79:655-60 pubmed
    ..We examined the early events in infection that follow virus interaction with DAF, and with the coxsackievirus and adenovirus receptor (CAR)...
  46. Tamanini A, Nicolis E, Bonizzato A, Bezzerri V, Melotti P, Assael B, et al. Interaction of adenovirus type 5 fiber with the coxsackievirus and adenovirus receptor activates inflammatory response in human respiratory cells. J Virol. 2006;80:11241-54 pubmed
    ..5 (Ad2/5) enter respiratory epithelia after initial binding of fiber with the coxsackievirus-adenovirus receptor (CAR) or, alternatively, with cell surface heparan sulfate glycosaminoglycans...
  47. Marx Stoelting P, Ganzenberg K, Knebel C, Schmidt F, Rieke S, Hammer H, et al. Hepatotoxic effects of cyproconazole and prochloraz in wild-type and hCAR/hPXR mice. Arch Toxicol. 2017;91:2895-2907 pubmed publisher
    ..A 28-day toxicity study was conducted in mice with humanized CAR and PXR (hCAR/hPXR) with two dose levels (50 or 500 ppm) of both substances, using the model CAR activator phenobarbital as a ..
  48. Kesisoglou F, Schmiedlin Ren P, Fleisher D, Zimmermann E. Adenoviral transduction of enterocytes and M-cells using in vitro models based on Caco-2 cells: the coxsackievirus and adenovirus receptor (CAR) mediates both apical and basolateral transduction. Mol Pharm. 2010;7:619-29 pubmed publisher
    ..Transduction inhibition studies showed that CAR is the major receptor mediating apical and basolateral virus entry in differentiated Caco-2 cells...
  49. Selinka H, Wolde A, Sauter M, Kandolf R, Klingel K. Virus-receptor interactions of coxsackie B viruses and their putative influence on cardiotropism. Med Microbiol Immunol. 2004;193:127-31 pubmed
    ..of group B (CVB) specifically interact with at least two receptor proteins, the coxsackievirus-adenovirus receptor (CAR) and the decay-accelerating factor (DAF), and cause a broad spectrum of diseases, including acute and chronic ..
  50. Ma Y, Wang X, Han Y, Li G, Wang H, Wang S, et al. Loss of coxsackie and adenovirus receptor expression in human colorectal cancer: A potential impact on the efficacy of adenovirus-mediated gene therapy in Chinese Han population. Mol Med Rep. 2016;14:2541-7 pubmed publisher
    The coxsackie and adenovirus receptor (CAR) is considered a tumor suppressor and critical factor for the efficacy of therapeutic strategies that employ the adenovirus...
  51. Lewis T, Glasgow J, Glandon A, Curiel D, Standaert D. Transduction of brain dopamine neurons by adenoviral vectors is modulated by CAR expression: rationale for tropism modified vectors in PD gene therapy. PLoS ONE. 2010;5: pubmed publisher
    ..Interestingly, hCAR protein localizes with markers of post-synaptic structures, suggesting synapses are the point of entry into ..
  52. Wang X, Liu L. Crystal Structure and Catalytic Mechanism of 7-Hydroxymethyl Chlorophyll a Reductase. J Biol Chem. 2016;291:13349-59 pubmed publisher
    7-Hydroxymethyl chlorophyll a reductase (HCAR) catalyzes the second half-reaction in chlorophyll b to chlorophyll a conversion...
  53. Yu L, Wang Z, Huang M, Li Y, Zeng K, Lei J, et al. Evodia alkaloids suppress gluconeogenesis and lipogenesis by activating the constitutive androstane receptor. Biochim Biophys Acta. 2016;1859:1100-11 pubmed publisher
    ..Rut) and evodiamine (Evo), on gluconeogenesis and lipogenesis through their activation of the human CAR (hCAR)...
  54. Saito K, Sakaguchi M, Iioka H, Matsui M, Nakanishi H, Huh N, et al. Coxsackie and adenovirus receptor is a critical regulator for the survival and growth of oral squamous carcinoma cells. Oncogene. 2014;33:1274-86 pubmed publisher
    Coxsackie and adenovirus receptor (CAR) is essential for adenovirus infection to target cells, and its constitutive expression in various cancerous and normal tissues has been reported...
  55. Toivonen R, Mäyränpää M, Kovanen P, Savontaus M. Dilated cardiomyopathy alters the expression patterns of CAR and other adenoviral receptors in human heart. Histochem Cell Biol. 2010;133:349-57 pubmed publisher
    ..of cardiac expression of receptors for several adenovirus serotypes with a focus on differential expression of CAR and CD46, as adenoviruses targeting these receptors have been used in various applications...
  56. Pinkert S, Röger C, Kurreck J, Bergelson J, Fechner H. The Coxsackievirus and Adenovirus Receptor: Glycosylation and the Extracellular D2 Domain Are Not Required for Coxsackievirus B3 Infection. J Virol. 2016;90:5601-5610 pubmed publisher
    The coxsackievirus and adenovirus receptor (CAR) is a member of the immunoglobulin superfamily (IgSF) and functions as a receptor for coxsackie B viruses (CVBs)...
  57. Noutsias M, Fechner H, de Jonge H, Wang X, Dekkers D, Houtsmuller A, et al. Human coxsackie-adenovirus receptor is colocalized with integrins alpha(v)beta(3) and alpha(v)beta(5) on the cardiomyocyte sarcolemma and upregulated in dilated cardiomyopathy: implications for cardiotropic viral infections. Circulation. 2001;104:275-80 pubmed
    The coxsackievirus and adenovirus receptor (CAR) was identified as a common cellular receptor for both viruses, but its biological and pathogenic relevance is uncertain...
  58. Inoue K, Negishi M. Early growth response 1 loops the CYP2B6 promoter for synergistic activation by the distal and proximal nuclear receptors CAR and HNF4alpha. FEBS Lett. 2009;583:2126-30 pubmed publisher
    Nuclear xenobiotic receptor CAR activates transcription of the CYP2B6 gene by directly binding to the distal enhancer PB responsive enhancer module (PBREM)...
  59. Cabrele C, Vogel M, Piso P, Rentsch M, Schröder J, Jauch K, et al. 5-Fluorouracil-related enhancement of adenoviral infection is Coxsackievirus-adenovirus receptor independent and associated with morphological changes in lipid membranes. World J Gastroenterol. 2006;12:5168-74 pubmed
    ..To evaluate the mechanism underlying the effects of 5-Fluorouracil (5-FU) on adenoviral infection...
  60. Serrano M, Moreno M, Bassols J, Moreno Navarrete J, Ortega F, Ricart W, et al. Coxsackie and adenovirus receptor is increased in adipose tissue of obese subjects: a role for adenovirus infection?. J Clin Endocrinol Metab. 2015;100:1156-63 pubmed publisher
    The coxsackie and adenovirus receptor (CAR) was originally identified as a common receptor for coxsackie B viruses and type C adenoviruses...
  61. Lenman A, Liaci A, Liu Y, Ã…rdahl C, Rajan A, Nilsson E, et al. Human adenovirus 52 uses sialic acid-containing glycoproteins and the coxsackie and adenovirus receptor for binding to target cells. PLoS Pathog. 2015;11:e1004657 pubmed publisher
    ..attach to host cells by means of the protruding fiber protein that binds to host cells via the coxsackievirus and adenovirus receptor (CAR) protein...
  62. Li H, Li Y, Zhu T. [The expression of coxsackie B virus adenovirus receptor (CAR) in viral myocarditis and dilated cardiomyopathy patients]. Fa Yi Xue Za Zhi. 2007;23:247-9 pubmed
    ..The expression of Coxsackie B virus and adenovirus receptors (CAR) were detected with modified immunohistochemical (IHC) technique in myocardium of left ventricle, right ventricle, ..
  63. Jyrkkärinne J, Windshügel B, Mäkinen J, Ylisirniö M, PERAKYLA M, Poso A, et al. Amino acids important for ligand specificity of the human constitutive androstane receptor. J Biol Chem. 2005;280:5960-71 pubmed
    The human constitutive androstane receptor (CAR, NR1I3) is an important ligand-activated regulator of oxidative and conjugative enzymes and transport proteins...
  64. Piao W, Han S, Sakuraba Y, Paek N. Rice 7-Hydroxymethyl Chlorophyll a Reductase Is Involved in the Promotion of Chlorophyll Degradation and Modulates Cell Death Signaling. Mol Cells. 2017;40:773-786 pubmed publisher
    ..The Chl catabolic enzyme 7-hydroxymethyl Chl a reductase (HCAR) converts 7-hydroxymethyl Chl a (7-HMC a) to Chl a...