Gene Symbol: CAPN1
Description: calpain 1
Alias: CANP, CANP1, CANPL1, SPG76, muCANP, muCL, calpain-1 catalytic subunit, CANP 1, calcium-activated neutral proteinase 1, calpain 1, (mu/I) large subunit, calpain mu-type, calpain, large polypeptide L1, calpain-1 large subunit, cell proliferation-inducing gene 30 protein, cell proliferation-inducing protein 30, micromolar-calpain
Species: human
Products:     CAPN1

Top Publications

  1. Uemori T, Shimojo T, Asada K, Asano T, Kimizuka F, Kato I, et al. Characterization of a functional domain of human calpastatin. Biochem Biophys Res Commun. 1990;166:1485-93 pubmed
    ..Peptides that contained the M-sequence and some neighboring sequences were synthesized to measure the minimum size of the inhibitory peptide, which was the M-sequence with the next six residues on the amino terminal side. ..
  2. Lee M, Kwon Y, Li M, Peng J, Friedlander R, Tsai L. Neurotoxicity induces cleavage of p35 to p25 by calpain. Nature. 2000;405:360-4 pubmed
    ..Furthermore, inhibition of cdk5 or calpain activity reduces cell death in A beta-treated cortical neurons. These observations indicate that cleavage of p35 to p25 by calpain may be involved in the pathogenesis of Alzheimer's disease. ..
  3. Goll D, Thompson V, Li H, Wei W, Cong J. The calpain system. Physiol Rev. 2003;83:731-801 pubmed
    ..Deregulated calpain activity following loss of Ca2+ homeostasis results in tissue damage in response to events such as myocardial infarcts, stroke, and brain trauma. ..
  4. Polster B, Basañez G, Etxebarria A, Hardwick J, Nicholls D. Calpain I induces cleavage and release of apoptosis-inducing factor from isolated mitochondria. J Biol Chem. 2005;280:6447-54 pubmed
    ..Taken together, these results define a novel mechanism of AIF release involving calpain processing and identify a potential molecular checkpoint for cytoprotective interventions. ..
  5. Munarriz E, Bano D, Sayan A, Rossi M, Melino G, Nicotera P. Calpain cleavage regulates the protein stability of p73. Biochem Biophys Res Commun. 2005;333:954-60 pubmed
    ..This suggests that calpains may play a physiological role in the regulation of p73 protein stability. ..
  6. Randriamboavonjy V, Pistrosch F, Bölck B, Schwinger R, Dixit M, Badenhoop K, et al. Platelet sarcoplasmic endoplasmic reticulum Ca2+-ATPase and mu-calpain activity are altered in type 2 diabetes mellitus and restored by rosiglitazone. Circulation. 2008;117:52-60 pubmed
    ..These data identify megakaryocytes/platelets as additional cellular targets for peroxisome proliferator-activated receptor-gamma agonists and highlight potential benefits of rosiglitazone therapy in cardiovascular diseases. ..
  7. Gafni J, Cong X, Chen S, Gibson B, Ellerby L. Calpain-1 cleaves and activates caspase-7. J Biol Chem. 2009;284:25441-9 pubmed publisher
    ..Our studies suggest the calpain-activated form of caspase-7 has unique enzymatic activity, localization, and binding affinity when compared with the caspase-activated form. ..
  8. Ferreira A, Bigio E. Calpain-mediated tau cleavage: a mechanism leading to neurodegeneration shared by multiple tauopathies. Mol Med. 2011;17:676-85 pubmed publisher
    ..Collectively, these data suggest that the mechanism underlying the generation of the 17-kDa neurotoxic tau fragment might be part of a conserved pathologic process shared by multiple tauopathies. ..
  9. Huang Y, Wang K. The calpain family and human disease. Trends Mol Med. 2001;7:355-62 pubmed
    ..This review describes our current understanding of the calpain family members and their mechanistic linkages to the aforementioned diseases as well as other emerging pathological conditions. ..

More Information

Publications136 found, 100 shown here

  1. Gil Parrado S, Popp O, Knoch T, Zahler S, Bestvater F, Felgenträger M, et al. Subcellular localization and in vivo subunit interactions of ubiquitous mu-calpain. J Biol Chem. 2003;278:16336-46 pubmed
    ..We propose that intracellular localization and in particular membrane targeting of activated calpain, but not dissociation of its intact subunits, contribute to regulate its proteolytic activity in vivo. ..
  2. Liu F, Grundke Iqbal I, Iqbal K, Oda Y, Tomizawa K, Gong C. Truncation and activation of calcineurin A by calpain I in Alzheimer disease brain. J Biol Chem. 2005;280:37755-62 pubmed
    ..These findings suggest that the overactivation of calpain I and calcineurin may mediate the role of calcium homeostatic disturbance in the neurodegeneration of AD. ..
  3. Xia H, Zhang L, Chen G, Zhang T, Liu J, Jin M, et al. Control of basal autophagy by calpain1 mediated cleavage of ATG5. Autophagy. 2010;6:61-6 pubmed
    ..We conclude that calpain1 plays an important role in controlling the levels of autophagy in normal living cells by regulating the levels of a key signaling molecule, ATG12-ATG5 conjugate. ..
  4. Hood J, Brooks W, Roszman T. Differential compartmentalization of the calpain/calpastatin network with the endoplasmic reticulum and Golgi apparatus. J Biol Chem. 2004;279:43126-35 pubmed
    ..These results provide a new and novel explanation for how the calpain/calpastatin network is organized in the cell. ..
  5. Courdier Fruh I, Briguet A. Utrophin is a calpain substrate in muscle cells. Muscle Nerve. 2006;33:753-9 pubmed
    ..These observations suggest that, beside its known effect on general muscle protein degradation, calpain contributes to DMD pathology by specifically degrading the compensatory protein utrophin. ..
  6. Averna M, Stifanese R, Grosso R, Pedrazzi M, De Tullio R, Salamino F, et al. Role of calpain in the regulation of CFTR (cystic fibrosis transmembrane conductance regulator) turnover. Biochem J. 2010;430:255-63 pubmed publisher
    ..These findings provide new insights into the molecular mechanisms responsible for the defective functions of ion channels in human pathologies. ..
  7. Hein T, Rosa R, Ren Y, Xu W, Kuo L. VEGF Receptor-2-Linked PI3K/Calpain/SIRT1 Activation Mediates Retinal Arteriolar Dilations to VEGF and Shear Stress. Invest Ophthalmol Vis Sci. 2015;56:5381-9 pubmed publisher
    ..It appears that NOS stimulation via PI3K, calpain proteases, and SIRT1-dependent deacetylation downstream from VEGFR2 activation contributes to these vasodilator responses. ..
  8. Davis B, Stucke E, Khorki M, LITOSH V, Rymer J, Rochman M, et al. Eosinophilic esophagitis-linked calpain 14 is an IL-13-induced protease that mediates esophageal epithelial barrier impairment. JCI Insight. 2016;1:e86355 pubmed
    ..Importantly, these findings were specific to CAPN14, as they were not observed with modulation of CAPN1 expression...
  9. Biazi B, Zanetti T, Baranoski A, Corveloni A, Mantovani M. Cis-Nerolidol Induces Endoplasmic Reticulum Stress and Cell Death in Human Hepatocellular Carcinoma Cells through Extensive CYP2C19 and CYP1A2 Oxidation. Basic Clin Pharmacol Toxicol. 2017;121:334-341 pubmed publisher
    ..RT-qPCR showed that C-NER down-regulated genes related to apoptosis (BAK1, BAX, CAPN1, CASP8, CASP9, PARP1 and TP53), cell cycle (CCND1, CCNE1, CDK1 and CDK2), xenobiotic metabolism (CYP2D6 and CYP3A4)..
  10. Ambriz Vilchis V, Jessop N, Fawcett R, Webster M, Shaw D, Walker N, et al. Effect of yeast supplementation on performance, rumination time, and rumen pH of dairy cows in commercial farm environments. J Dairy Sci. 2017;100:5449-5461 pubmed publisher
    The aims of the present study were to evaluate the effects of live yeast supplementation (Vistacell MUCL 39855, AB Vista, Marlborough, UK) on performance, rumination time, and rumen pH on dairy cows in commercial farm environments...
  11. Chave M, Crozilhac P, Deberdt P, Plouznikoff K, Declerck S. Rhizophagus irregularis MUCL 41833 transitorily reduces tomato bacterial wilt incidence caused by Ralstonia solanacearum under in vitro conditions. Mycorrhiza. 2017;27:719-723 pubmed publisher vitro culture conditions in the presence or absence of the arbuscular mycorrhizal fungus Rhizophagus irregularis MUCL 41833. A mycelium donor plant (i.e...
  12. Stabach P, Cianci C, Glantz S, Zhang Z, Morrow J. Site-directed mutagenesis of alpha II spectrin at codon 1175 modulates its mu-calpain susceptibility. Biochemistry. 1997;36:57-65 pubmed
    ..We conclude that secondary and tertiary conformational features surrounding the cleavage site, rather than the linear sequence itself, dominate the determinants that define alpha II spectrin's mu-calpain susceptibility. ..
  13. Chen Y, Yin D, Li L, Deng Y, Tian W. Screening aberrant methylation profile in esophageal squamous cell carcinoma for Kazakhs in Xinjiang area of China. Mol Biol Rep. 2015;42:457-64 pubmed publisher
    ..ALDH1L1 participated in folinic acid catabolism and CAPN1 positively regulated the cell proliferation...
  14. Rohdin C, Gilliam D, O Leary C, O Brien D, Coates J, Johnson G, et al. A KCNJ10 mutation previously identified in the Russell group of terriers also occurs in Smooth-Haired Fox Terriers with hereditary ataxia and in related breeds. Acta Vet Scand. 2015;57:26 pubmed publisher
    ..Recently, molecular genetic studies on the Russell group of terriers found independent mutations in KCNJ10 and CAPN1, each associated with a specific clinical subtype of inherited ataxia...
  15. Wang Y, White M, Akay C, Chodroff R, Robinson J, Lindl K, et al. Activation of cyclin-dependent kinase 5 by calpains contributes to human immunodeficiency virus-induced neurotoxicity. J Neurochem. 2007;103:439-55 pubmed
    ..Taken together, our data suggest calpain activation of CDK5, a pathway activated in HIV-infected individuals, can mediate neuronal damage and death in a model of HIV-induced neurotoxicity. ..
  16. Huang W, Zhou W, Saberwal G, Konieczna I, Horvath E, Katsoulidis E, et al. Interferon consensus sequence binding protein (ICSBP) decreases beta-catenin activity in myeloid cells by repressing GAS2 transcription. Mol Cell Biol. 2010;30:4575-94 pubmed publisher
    ..Therefore, these studies have identified a Gas2/calpain-dependent mechanism by which ICSBP influences beta-catenin activity in myeloid leukemia. ..
  17. O Connor P, Lapointe T, Jackson S, Beck P, Jones N, Buret A. Helicobacter pylori activates calpain via toll-like receptor 2 to disrupt adherens junctions in human gastric epithelial cells. Infect Immun. 2011;79:3887-94 pubmed publisher
    ..pylori. Inhibition of TLR2 prevented H. pylori-induced calpain activation and AJ disassembly. Together, these findings identify a novel pathway whereby H. pylori activates calpain via TLR2 to disrupt gastric epithelial AJ structure...
  18. Barendse W. Haplotype analysis improved evidence for candidate genes for intramuscular fat percentage from a genome wide association study of cattle. PLoS ONE. 2011;6:e29601 pubmed publisher
    ..effects for the genes ADIPOQ and CXCR4, as well as suggestive associations to the genes CEBPA, FASN, and CAPN1. Haplotypes for these genes explained 80% more of the phenotypic variance compared to the best single SNP...
  19. Hossain M, Roulston C, Kamaruddin M, Chu P, Ng D, Dusting G, et al. A truncated fragment of Src protein kinase generated by calpain-mediated cleavage is a mediator of neuronal death in excitotoxicity. J Biol Chem. 2013;288:9696-709 pubmed publisher
    ..Besides unveiling a new pathological action of Src, our discovery of the neurotoxic action of the truncated Src fragment suggests new therapeutic strategies with the potential to minimize brain damage in ischemic stroke. ..
  20. Lojan P, Demortier M, Velivelli S, Pfeiffer S, Suárez J, de Vos P, et al. Impact of plant growth-promoting rhizobacteria on root colonization potential and life cycle of Rhizophagus irregularis following co-entrapment into alginate beads. J Appl Microbiol. 2017;122:429-440 pubmed publisher
    ..of seven plant growth-promoting rhizobacteria (PGPR) on root colonization and life cycle of Rhizophagus irregularis MUCL 41833 when co-entrapped in alginate beads. Two in vitro experiments were conducted...
  21. Ishiguro H, Higashiyama S, Namikawa C, Kunimatsu M, Takano E, Tanaka K, et al. Interaction of human calpains I and II with high molecular weight and low molecular weight kininogens and their heavy chain: mechanism of interaction and the role of divalent cations. Biochemistry. 1987;26:2863-70 pubmed
    ..Some other divalent cations such as Mn2+, Sr2+, and Ba2+ were also able to induce the complex formation between calpains and kininogens.(ABSTRACT TRUNCATED AT 250 WORDS) ..
  22. Löfvenberg L, Backman L. Calpain-induced proteolysis of beta-spectrins. FEBS Lett. 1999;443:89-92 pubmed
    ..Surprisingly, beta1sigma-spectrin is cleaved at a different site than betaIsigma2- and betaIIsigma1-spectrins despite their high degree of sequence identity. ..
  23. Struewing I, Barnett C, Zhang W, Yadav S, Mao C. Frizzled-7 turnover at the plasma membrane is regulated by cell density and the Ca(2+) -dependent protease calpain-1. Exp Cell Res. 2007;313:3526-41 pubmed
    ..Altogether, our findings pinpoint calpain-1 as a regulator of Frizzled-7 turnover at the plasma membrane and reveal a link between Frizzled-7 cleavage and its activity. ..
  24. Gasperi V, Rapino C, Battista N, Bari M, Mastrangelo N, Angeletti S, et al. A functional interplay between 5-lipoxygenase and μ-calpain affects survival and cytokine profile of human Jurkat T lymphocyte exposed to simulated microgravity. Biomed Res Int. 2014;2014:782390 pubmed publisher
    ..Indeed, we report unprecedented evidence that 5-LOX inhibition reduced apoptotic death, restored the initial IL-2/INF-γ ratio, and more importantly reverted µ-calpain activation induced by simulated microgravity. ..
  25. Gan Or Z, Bouslam N, Birouk N, Lissouba A, Chambers D, Vérièpe J, et al. Mutations in CAPN1 Cause Autosomal-Recessive Hereditary Spastic Paraplegia. Am J Hum Genet. 2016;98:1038-1046 pubmed publisher additional family members confirmed the segregation of these mutations with the disease (spastic paraplegia 76 [SPG76]). CAPN1 encodes calpain 1, a protease that is widely present in the CNS...
  26. Averna M, Bavestrello M, Cresta F, Pedrazzi M, De Tullio R, Minicucci L, et al. Abnormal activation of calpain and protein kinase Cα promotes a constitutive release of matrix metalloproteinase 9 in peripheral blood mononuclear cells from cystic fibrosis patients. Arch Biochem Biophys. 2016;604:103-12 pubmed publisher
  27. Kamei H, Saito T, Ozawa M, Fujita Y, Asada A, Bibb J, et al. Suppression of calpain-dependent cleavage of the CDK5 activator p35 to p25 by site-specific phosphorylation. J Biol Chem. 2007;282:1687-94 pubmed
  28. Michetti M, Salamino F, Tedesco I, Averna M, Minafra R, Melloni E, et al. Autolysis of human erythrocyte calpain produces two active enzyme forms with different cell localization. FEBS Lett. 1996;392:11-5 pubmed
    ..Further autoproteolytic intermolecular digestion converts the 78 kDa to the 75 kDa form, no longer being retained by the membrane. This process generates two active forms of calpain, with different intracellular localisations. ..
  29. Govindarajan B, Laird J, Salomon R, Bhattacharya S. Isolevuglandin-modified proteins, including elevated levels of inactive calpain-1, accumulate in glaucomatous trabecular meshwork. Biochemistry. 2008;47:817-25 pubmed
    ..These data suggest that interference with proteasomal activity, owing to protein modification by isoLGs, could contribute to glaucoma pathophysiology by decreasing the ability of the TM to modulate outflow resistance. ..
  30. Yurkov A, Kachalkin A, Daniel H, Groenewald M, Libkind D, de García V, et al. Two yeast species Cystobasidium psychroaquaticum f.a. sp. nov. and Cystobasidium rietchieii f.a. sp. nov. isolated from natural environments, and the transfer of Rhodotorula minuta clade members to the genus Cystobasidium. Antonie Van Leeuwenhoek. 2015;107:173-85 pubmed publisher
    ..a. sp. nov. (K-833(T) = KBP 3881(T) = VKPM Y-3653(T) = CBS 11769(T) = MUCL 52875(T) = DSM 27713(T)) and Cystobasidium rietchiei f.a. sp. nov...
  31. Guo A, Hall D, Zhang C, Peng T, Miller J, Kutschke W, et al. Molecular Determinants of Calpain-dependent Cleavage of Junctophilin-2 Protein in Cardiomyocytes. J Biol Chem. 2015;290:17946-55 pubmed publisher
    ..These data provide new molecular insights into the posttranslational regulatory mechanisms of JP2 in cardiac diseases. ..
  32. Castro S, Ríos M, Ortiz Y, Manrique C, Jiménez A, Ariza F. Association of single nucleotide polymorphisms in CAPN1, CAST and MB genes with meat color of Brahman and crossbreed cattle. Meat Sci. 2016;117:44-9 pubmed publisher
    The objective of this research was to determine the association of SNPs in the candidate genes Calpain (CAPN1), Calpastatin (CAST) and Myoglobin (MB) with colorimetric parameters (L *, a *, b *, C *, hue) in a F1 population (n = 164) ..
  33. Gluck M, Beck C, Golan E, Nasser P, Shukla D, Hausman M. Varus posteromedial rotatory instability: a biomechanical analysis of posterior bundle of the medial ulnar collateral ligament reconstruction. J Shoulder Elbow Surg. 2018;27:1317-1325 pubmed publisher
    ..Specimens were assessed at "intact," "cut coronoid?+?pMUCL," "reconstruction," and "cut anterior aspect MUCL?+?reconstruction" conditions with mechanical testing at 30°, 60°, and 90° of elbow flexion...
  34. Ohno S, Minoshima S, Kudoh J, Fukuyama R, Shimizu Y, Ohmi Imajoh S, et al. Four genes for the calpain family locate on four distinct human chromosomes. Cytogenet Cell Genet. 1990;53:225-9 pubmed
    ..The genes for calpain L1 (CAPN1, large subunit of calpain I), L2 (CAPN2, large subunit of calpain II), L3 (CAPN3, a protein related to the large ..
  35. Perry S, Barbieri J, Tong N, Polesskaya O, Pudasaini S, Stout A, et al. Human immunodeficiency virus-1 Tat activates calpain proteases via the ryanodine receptor to enhance surface dopamine transporter levels and increase transporter-specific uptake and Vmax. J Neurosci. 2010;30:14153-64 pubmed publisher
    ..Finally, we provide key translational relevance for these findings by highlighting published human data of increased DAT levels in striata of HAND patients and by demonstrating similar findings in Tat-expressing transgenic mice. ..
  36. Al Bahlani S, Fraser M, Wong A, Sayan B, Bergeron R, Melino G, et al. P73 regulates cisplatin-induced apoptosis in ovarian cancer cells via a calcium/calpain-dependent mechanism. Oncogene. 2011;30:4219-30 pubmed publisher
    ..Understanding the cellular and molecular mechanisms of chemoresistance will direct the development of effective strategies for the treatment of chemoresistant OVCA. ..
  37. Miners J, Renfrew R, Swirski M, Love S. Accumulation of α-synuclein in dementia with Lewy bodies is associated with decline in the α-synuclein-degrading enzymes kallikrein-6 and calpain-1. Acta Neuropathol Commun. 2014;2:164 pubmed publisher
    ..Our results indicate that reductions in kallikrein-6 and calpain-1 may contribute to the accumulation of α-synuclein in DLB. ..
  38. Yasuda K, Hirohashi Y, Kuroda T, Takaya A, Kubo T, Kanaseki T, et al. MAPK13 is preferentially expressed in gynecological cancer stem cells and has a role in the tumor-initiation. Biochem Biophys Res Commun. 2016;472:643-7 pubmed publisher
    ..CSCs/CICs isolated as aldehyde dehydrogenase high (ALDH(high)) cells, and found that MAPK13, PTTG1IP, CAPN1 and UBQLN2 were preferentially expressed in CSCs/CICs...
  39. Fernandez Montalvan A, Assfalg Machleidt I, Pfeiler D, Fritz H, Jochum M, Machleidt W. Mu-calpain binds to lipid bilayers via the exposed hydrophobic surface of its Ca2+-activated conformation. Biol Chem. 2006;387:617-27 pubmed
    ..Taken together, these results support the hypothesis that in vitro membrane binding of mu-calpain is due to the exposed hydrophobic surface of the active conformation and does not reduce the Ca2+ requirement for activation. ..
  40. Tanner J, Frey B, Pemberton T, Henzl M. EF5 Is the High-Affinity Mg(2+) Site in ALG-2. Biochemistry. 2016;55:5128-41 pubmed publisher
    ..Sequence data for other PEF proteins indicate that select calpain large subunits, notably CAPN1 and CAPN8, may also possess a high-affinity Mg(2+)-binding site...
  41. Jouda J, Mfotie Njoya E, Mbazoa C, Zhou Z, Meli Lannang A, Wandji J, et al. Lambertellin from Pycnoporus sanguineus MUCL 51321 and its anti-inflammatory effect via modulation of MAPK and NF-?B signaling pathways. Bioorg Chem. 2018;80:216-222 pubmed publisher
    ..2) were isolated from the solid rice fermentation of the plant pathogenic fungus Pycnoporus sanguineus MUCL 51321. Their structures were elucidated using comprehensive spectroscopic methods...
  42. Hashimoto Y, Inagaki H, Hoshino S. Calpain mediates processing of the translation termination factor eRF3 into the IAP-binding isoform p-eRF3. FEBS Lett. 2015;589:2241-7 pubmed publisher
    ..p-eRF3 is produced in cells treated with ER stressors in a calpain-dependent manner. These findings suggest that p-eRF3 is a novel regulator of calpain-dependent cell death. ..
  43. Raimondi M, Marcassa E, Cataldo F, Arnandis T, Mendoza Maldonado R, Bestagno M, et al. Calpain restrains the stem cells compartment in breast cancer. Cell Cycle. 2016;15:106-16 pubmed publisher
    CAPNS1 is essential for the stability and function of ubiquitous CAPN1 and CAPN2...
  44. Mauro A, Garcia Cela E, Pietri A, Cotty P, Battilani P. Biological Control Products for Aflatoxin Prevention in Italy: Commercial Field Evaluation of Atoxigenic Aspergillus flavus Active Ingredients. Toxins (Basel). 2018;10: pubmed publisher
    ..deposited under provisions of the Budapest Treaty in the Belgian Co-Ordinated Collections of Micro-Organisms (BCCM/MUCL) collection (accession MUCL54911)...
  45. Fukuta S, Miyamoto K, Suzuki K, Maehara H, Inoue T, Hara A, et al. Abundance of calpain and aggrecan-cleavage products of calpain in degenerated human intervertebral discs. Osteoarthritis Cartilage. 2011;19:1254-62 pubmed publisher
    ..These findings suggest that calpains may be involved in IVD degeneration via proteoglycan (PG) cleavage. ..
  46. Croall D, Vanhooser L, Cashon R. Detecting the active conformation of calpain with calpastatin-based reagents. Biochim Biophys Acta. 2008;1784:1676-86 pubmed publisher
    ..These data also provide proof of concept that the calpastatin-based reagents may be useful to selectively detect the active conformation of calpain. ..
  47. Ke L, Qi X, Dijkhuis A, Chartier D, Nattel S, Henning R, et al. Calpain mediates cardiac troponin degradation and contractile dysfunction in atrial fibrillation. J Mol Cell Cardiol. 2008;45:685-93 pubmed publisher
    ..Our results suggest that calpain inhibition may therefore represent a key target in combating AF-related structural and functional remodeling. ..
  48. Zocco D, van Aarle I, Oger E, Lanfranco L, Declerck S. Fenpropimorph and fenhexamid impact phosphorus translocation by arbuscular mycorrhizal fungi. Mycorrhiza. 2011;21:363-374 pubmed publisher
    ..In the present study, we investigated the capacity of Glomus sp. MUCL 43204 to take up, transfer and translocate labelled P to Medicago truncatula in the presence of these SBI molecules...
  49. Hossain M, Richardson J. Mechanism of pyrethroid pesticide-induced apoptosis: role of calpain and the ER stress pathway. Toxicol Sci. 2011;122:512-25 pubmed publisher
  50. Lu J, Lu W, Lai J, Tsai F, Wu S, Lin C, et al. Calcium flux and calpain-mediated activation of the apoptosis-inducing factor contribute to enterovirus 71-induced apoptosis. J Gen Virol. 2013;94:1477-85 pubmed publisher
    ..These findings should be useful for understanding the virus-induced cytopathology and the impact of Ca²? homeostasis on EV71 infection. ..
  51. Aoyama K, Ozaki Y, Nakanishi T, Ogasawara M, Ikuta K, Aoki K, et al. Cleavage of integrin by mu-calpain during hypoxia in human endometrial cells. Am J Reprod Immunol. 2004;52:362-9 pubmed
    ..Mu-calpain is activated in human endometrial cells during hypoxia and that subsequent cleavage of the integrin beta3 cytoplasmic domain may give some adverse effects to the function of human endometrium. ..
  52. López Rojas L, Patiño Cadavid L, López Herrera A, Echeverri Zuluaga J. Genotyping of SNPs associated with meat tenderness: comparison of two PCR-based methods. Genet Mol Res. 2017;16: pubmed publisher
    Single nucleotide polymorphisms (SNPs) carried in calpain (CAPN1), calpastatin (CAST), and leptin (LEP) genes are associated with meat tenderness...
  53. Franekova V, Baliova M, Jursky F. Truncation of human dopamine transporter by protease calpain. Neurochem Int. 2008;52:1436-41 pubmed publisher
    ..The above suggests that cleavage of DAT by calpain may significantly modify dopamine homeostasis under pathological or physiological conditions. ..
  54. Randriamboavonjy V, Fleming I. The role of calpain in diabetes-associated platelet hyperactivation. Adv Pharmacol. 2010;59:235-57 pubmed publisher
    ..Finally, we will discuss future therapeutic possibilities for the improvement of diabetes-associated vascular diseases. ..
  55. Kovacs L, Su Y. Redox-Dependent Calpain Signaling in Airway and Pulmonary Vascular Remodeling in COPD. Adv Exp Med Biol. 2017;967:139-160 pubmed publisher
    ..Further investigation of the redox-dependent calpain signaling may provide future targets for the prevention and treatment of COPD. ..
  56. Bi R, Rong Y, Bernard A, Khrestchatisky M, Baudry M. Src-mediated tyrosine phosphorylation of NR2 subunits of N-methyl-D-aspartate receptors protects from calpain-mediated truncation of their C-terminal domains. J Biol Chem. 2000;275:26477-83 pubmed
    ..We propose that phosphorylation of NR2 subunits and the resulting inhibition of calpain-mediated truncation of their C-terminal domains provide for the stabilization of the N-methyl-d-aspartate receptors in postsynaptic structures. ..
  57. Tait R, Cushman R, McNeel A, Casas E, Smith T, Freetly H, et al. ?-Calpain (CAPN1), calpastatin (CAST), and growth hormone receptor (GHR) genetic effects on Angus beef heifer performance traits and reproduction. Theriogenology. 2018;113:1-7 pubmed publisher
    ..An Angus population was subjected to marker assisted selection for multiple years to equalize CAPN1 haplotypes, CAST, and GHR genetic marker frequencies...
  58. Kulkarni S, Jackson S. Platelet factor XIII and calpain negatively regulate integrin alphaIIbbeta3 adhesive function and thrombus growth. J Biol Chem. 2004;279:30697-706 pubmed
    ..Moreover, they demonstrate the existence of an autoregulatory feedback mechanism that serves to limit excessive platelet accumulation on highly reactive thrombogenic surfaces. ..
  59. Zhang P, Sridharan D, Lambert M. Knockdown of mu-calpain in Fanconi anemia, FA-A, cells by siRNA restores alphaII spectrin levels and corrects chromosomal instability and defective DNA interstrand cross-link repair. Biochemistry. 2010;49:5570-81 pubmed publisher
    ..Thus, by reducing the level of breakdown of alphaIISp in FA cells, we may be able to reverse a number of the cellular deficiencies observed in this disorder. ..
  60. Lu Y, Bradley J, McCoski S, Gonzalez J, Ealy A, Johnson S. Reduced skeletal muscle fiber size following caloric restriction is associated with calpain-mediated proteolysis and attenuation of IGF-1 signaling. Am J Physiol Regul Integr Comp Physiol. 2017;312:R806-R815 pubmed publisher
    ..Smaller CR LM fiber size associates with increased (P < 0.05) calpain 1 (CAPN1) activity coupled with lower (P < 0...
  61. Gil Cardeza M, Calonne Salmon M, Gomez E, Declerck S. Short-term chromium (VI) exposure increases phosphorus uptake by the extraradical mycelium of the arbuscular mycorrhizal fungus Rhizophagus irregularis MUCL 41833. Chemosphere. 2017;187:27-34 pubmed publisher
    ..This study investigated the impact of Cr(VI) on short-term P uptake by the AMF Rhizophagus irregularis MUCL 41833 in Medicago truncatula...
  62. Rutledge T, Whiteheart S. SNAP-23 is a target for calpain cleavage in activated platelets. J Biol Chem. 2002;277:37009-15 pubmed
    ..This is consistent with the ultrastructural morphology of calpeptin-treated platelets after activation. ..
  63. Michel L, Hoenderop J, Bindels R. Calpain-3-mediated regulation of the Na⁺-Ca²⁺ exchanger isoform 3. Pflugers Arch. 2016;468:243-55 pubmed publisher
    ..Since NCX3 is expressed in skeletal muscle, we evaluated the cleavage of different NCX3 splice variants by CAPN1 and CAPN3...
  64. Imam S, Guyton M, Haque A, Vandenbark A, Tyor W, Ray S, et al. Increased calpain correlates with Th1 cytokine profile in PBMCs from MS patients. J Neuroimmunol. 2007;190:139-45 pubmed
    ..Calpain inhibitor also reduced degradation of myelin basic protein (MBP) by inhibiting the calpain secreted from MBP-specific T cells. Taken together, these results suggested calpain involvement in Th1/Th2 dysregulation in MS patients. ..
  65. Badugu R, Garcia M, Bondada V, Joshi A, Geddes J. N terminus of calpain 1 is a mitochondrial targeting sequence. J Biol Chem. 2008;283:3409-17 pubmed
  66. Aoki K, Imajoh S, Ohno S, Emori Y, Koike M, Kosaki G, et al. Complete amino acid sequence of the large subunit of the low-Ca2+-requiring form of human Ca2+-activated neutral protease (muCANP) deduced from its cDNA sequence. FEBS Lett. 1986;205:313-7 pubmed
    ..sequence of the large subunit (catalytic subunit) of human low-Ca2+-requiring-calcium-activated neutral protease (muCANP) was deduced from its cDNA base sequence...
  67. Pu X, Storr S, Ahmad N, Chan S, Moseley P, Televantou D, et al. Calpain-1 is associated with adverse relapse free survival in breast cancer: a confirmatory study. Histopathology. 2016;68:1021-9 pubmed publisher
    ..Further work is warranted to standardize and develop methodology with a view to potentially introducing assessment of this important biomarker into clinical practice. ..
  68. Sorimachi H, Ohmi S, Emori Y, Kawasaki H, Saido T, Ohno S, et al. A novel member of the calcium-dependent cysteine protease family. Biol Chem Hoppe Seyler. 1990;371 Suppl:171-6 pubmed
    ..The encoded protein, designated tentatively as p94, is composed of four domains similar to those found in other CANP large subunits, but includes three unique regions that have no homology to other CANPs...
  69. Altznauer F, Conus S, Cavalli A, Folkers G, Simon H. Calpain-1 regulates Bax and subsequent Smac-dependent caspase-3 activation in neutrophil apoptosis. J Biol Chem. 2004;279:5947-57 pubmed
  70. Fang Z, Miao Y, Ding X, Deng H, Liu S, Wang F, et al. Proteomic identification and functional characterization of a novel ARF6 GTPase-activating protein, ACAP4. Mol Cell Proteomics. 2006;5:1437-49 pubmed
    ..Thus, our study sheds new light on the biological function of ARF6-mediated cell migration. ..
  71. Qadir M, Bhatti A, Ashraf M, Sandhu M, Anjum S, John P. Immunomodulatory and therapeutic role of Cinnamomum verum extracts in collagen-induced arthritic BALB/c mice. Inflammopharmacology. 2018;26:157-170 pubmed publisher
    ..Western blot analysis was performed on peripheral blood derived serum for CII, CAPN1, TNF? and NFATc3. Extracts were shown to be enriched in trans-cinnamaldehyde and its analogues...
  72. Olmos G, Arenas M, Bienes R, Calzada M, Aragones J, Garcia Bermejo M, et al. 15-Deoxy-Delta(12,14)-prostaglandin-J(2) reveals a new pVHL-independent, lysosomal-dependent mechanism of HIF-1alpha degradation. Cell Mol Life Sci. 2009;66:2167-80 pubmed publisher
    ..Therefore, expression of HIF-1alpha is also modulated by lysosomal degradation. ..
  73. Kim H, Kang A, Ko A, Park H, So I, Park J, et al. Calpain-mediated proteolysis of polycystin-1 C-terminus induces JAK2 and ERK signal alterations. Exp Cell Res. 2014;320:62-8 pubmed
    ..They suggest that the PC1 function on JAK2 and ERK signaling pathways might be regulated by calpains in response to the changes in intracellular calcium concentration. ..
  74. Cui X, Sun Y, Wang X, Yang C, Ju Z, Jiang Q, et al. A g.-1256 A>C in the promoter region of CAPN1 is associated with semen quality traits in Chinese Holstein bulls. Reproduction. 2016;152:101-9 pubmed publisher
    The micromolar calcium-activated neutral protease gene (CAPN1) is a physiological candidate gene for sperm motility. However, the molecular mechanisms involved in regulating the expression of the CAPN1 gene in bulls remain unknown...
  75. Ouoba L, Nielsen D, Anyogu A, Kando C, Diawara B, Jespersen L, et al. Hanseniaspora jakobsenii sp. nov., a yeast isolated from Bandji, a traditional palm wine of Borassus akeassii. Int J Syst Evol Microbiol. 2015;65:3576-9 pubmed publisher
    ..lindneri MUCL 31146T ( = NRRL Y-17531T), H...
  76. Starska K, Forma E, Jóźwiak P, Lewy Trenda I, Danilewicz M, Stasikowska Kanicka O, et al. Gene/protein expression of CAPN1/2-CAST system members is associated with ERK1/2 kinases activity as well as progression and clinical outcome in human laryngeal cancer. Tumour Biol. 2016;37:13185-13203 pubmed
    ..This study was aimed to evaluate the CAPN1/2-CAST-ERK1/2 enzyme system mRNA/protein level and to investigate whether they can promote the dynamic of tumor ..
  77. Park J, Chung S, Lee J, Lee J, Lee S, Ji H, et al. The effect of humeral tunnel locations on radiographic tunnel changes in baseball players following medial ulnar collateral ligament reconstruction: comparison of anatomic and nonanatomic locations. J Shoulder Elbow Surg. 2018;27:1037-1043 pubmed publisher
    There has been no study on radiologic changes after medial ulnar collateral ligament (MUCL) reconstruction and related clinical features. Data from 39 baseball players who underwent MUCL reconstruction were collected and analyzed...
  78. Corasaniti M, Navarra M, Catani M, Melino G, Nistico G, Finazzi Agro A. NMDA and HIV-1 coat protein, GP120, produce necrotic but not apoptotic cell death in human CHP100 neuroblastoma cultures via a mechanism involving calpain. Biochem Biophys Res Commun. 1996;229:299-304 pubmed
    ..Altogether the data indicate that neuroblastoma cell death induced by NMDA and gp120 is of the necrotic type and this implicates calpain protease. ..
  79. Oda A, Wakao H, Fujita H. Calpain is a signal transducer and activator of transcription (STAT) 3 and STAT5 protease. Blood. 2002;99:1850-2 pubmed
    ..Thus, our study reveals a novel pathway for posttranslational modification of STAT3 and STAT5. ..
  80. Mikosik A, Zaremba A, Puchalska Z, Daca A, Smolenska Z, Lopatniuk P, et al. Ex vivo measurement of calpain activation in human peripheral blood lymphocytes by detection of immunoreactive products of calpastatin degradation. Folia Histochem Cytobiol. 2007;45:343-7 pubmed
    ..Extremely high intrinsic activity of calpain was detected in chronic lymphocytic leukemia (CD19+) cells. All this confirms the detection of immunoreactive products of calpastatin as a good maker of endogenous calpain activity. ..
  81. Fan X, Zhang Q, You C, Qian Y, Gao J, Liu P, et al. Proteolysis of the human DNA polymerase delta smallest subunit p12 by ?-calpain in calcium-triggered apoptotic HeLa cells. PLoS ONE. 2014;9:e93642 pubmed publisher
    ..Thus, the p12/Pol ? is a target as a nuclear substrate of ?-calpain in a calcium-triggered apoptosis and appears to be a potential marker in the study of the chemotherapy of cancer therapies. ..
  82. Jin N, Yin X, Gu J, Zhang X, Shi J, Qian W, et al. Truncation and Activation of Dual Specificity Tyrosine Phosphorylation-regulated Kinase 1A by Calpain I: A MOLECULAR MECHANISM LINKED TO TAU PATHOLOGY IN ALZHEIMER DISEASE. J Biol Chem. 2015;290:15219-37 pubmed publisher
    ..Collectively, these findings suggest that truncation/activation of Dyrk1A by Ca(2+)/calpain I might contribute to Tau pathology via promotion of exon 10 exclusion and hyperphosphorylation of Tau in AD brain. ..
  83. Du X, Saido T, Tsubuki S, Indig F, Williams M, Ginsberg M. Calpain cleavage of the cytoplasmic domain of the integrin beta 3 subunit. J Biol Chem. 1995;270:26146-51 pubmed
    ..Thus, calpain cleavage of the beta 3 cytoplasmic domain may provide a means to regulate integrin signaling functions. ..
  84. Maruyama K, Usami M, Kametani F, Tomita T, Iwatsubo T, Saido T, et al. Molecular interactions between presenilin and calpain: inhibition of m-calpain protease activity by presenilin-1, 2 and cleavage of presenilin-1 by m-, mu-calpain. Int J Mol Med. 2000;5:269-73 pubmed
    ..These results suggest a regulatory function of presenilin on the calpain system. ..
  85. Smith I, Aversa Z, Hasselgren P, Pacelli F, Rosa F, Doglietto G, et al. Calpain activity is increased in skeletal muscle from gastric cancer patients with no or minimal weight loss. Muscle Nerve. 2011;43:410-4 pubmed publisher
    ..Calpain activity may be increased in muscle from gastric cancer patients even before changes in molecular markers of muscle wasting and significant weight loss occur. ..
  86. Li T, Lin T, Hsu S, Wu C, Su Y, Kao S, et al. The novel benzimidazole derivative, MPTB, induces cell apoptosis in human chondrosarcoma cells. Mol Carcinog. 2011;50:791-803 pubmed publisher
    ..Importantly, animal studies have revealed a dramatic 44% reduction in tumor volume after 21?d of treatment. This study demonstrates novel anti-cancer activity of MPTB against human chondrosarcoma cells and in murine tumor models...
  87. Al Omari M, Korenbaum E, Ballmaier M, Lehmann U, Jonigk D, Manstein D, et al. Acute-phase protein ?1-antitrypsin inhibits neutrophil calpain I and induces random migration. Mol Med. 2011;17:865-74 pubmed publisher
  88. Hsu C, Henry J, Raymond A, Méchin M, Pendaries V, Nassar D, et al. Deimination of human filaggrin-2 promotes its proteolysis by calpain 1. J Biol Chem. 2011;286:23222-33 pubmed publisher
    ..Altogether, these data demonstrate that calpain 1 is essential for the proteolytic processing of FLG2 and that deimination accelerates this process. ..
  89. Jiang L, Zhang J, Monticone R, Telljohann R, Wu J, Wang M, et al. Calpain-1 regulation of matrix metalloproteinase 2 activity in vascular smooth muscle cells facilitates age-associated aortic wall calcification and fibrosis. Hypertension. 2012;60:1192-9 pubmed publisher
    ..These results establish calpain-1 as a novel molecular candidate to retard age-associated extracellular matrix remodeling and its attendant risk for hypertension and atherosclerosis. ..
  90. Chen B, Tang J, Guo Y, Li Y, Chen Z, Jiang J. Calpains are required for invasive and metastatic potentials of human HCC cells. Cell Biol Int. 2013;37:643-52 pubmed publisher
    ..Thus µ- and m-calpain may play important roles in the invasion and metastasis of human hepatoma cells, and calpains may be drug targets for preventing HCC metastasis. ..
  91. Wang Y, Hersheson J, López D, Hammer M, Liu Y, Lee K, et al. Defects in the CAPN1 Gene Result in Alterations in Cerebellar Development and Cerebellar Ataxia in Mice and Humans. Cell Rep. 2016;16:79-91 pubmed publisher
    A CAPN1 missense mutation in Parson Russell Terrier dogs is associated with spinocerebellar ataxia...
  92. Goossens E, Wijnants M, Packet D, Lemiere F. Enhanced separation and analysis procedure reveals production of tri-acylated mannosylerythritol lipids by Pseudozyma aphidis. J Ind Microbiol Biotechnol. 2016;43:1537-1550 pubmed
    ..In this study, MELs were produced by fed-batch bioreactor fermentation of rapeseed oil with Pseudozyma aphidis MUCL 27852...