CA3

Summary

Gene Symbol: CA3
Description: carbonic anhydrase 3
Alias: CAIII, Car3, carbonic anhydrase 3, CA-III, HEL-S-167mP, carbonate dehydratase III, carbonic anhydrase III, muscle specific, epididymis secretory sperm binding protein Li 167mP
Species: human
Products:     CA3

Top Publications

  1. Cabiscol E, Levine R. The phosphatase activity of carbonic anhydrase III is reversibly regulated by glutathiolation. Proc Natl Acad Sci U S A. 1996;93:4170-4 pubmed
    Carbonic anhydrase isozyme III (CAIII) is unique among the carbonic anhydrases because it demonstrates phosphatase activity...
  2. Song X, Zhu S, Xie Y, Liu J, Sun L, Zeng D, et al. JTC801 Induces pH-dependent Death Specifically in Cancer Cells and Slows Growth of Tumors in Mice. Gastroenterology. 2018;154:1480-1493 pubmed publisher
    ..of JTC801 inhibited growth of xenograft tumors (from PANC1, MiaPaCa2, SK-MEL-28, PC-3, 786-0, SF-295, HCT116, OV-CAR3, and HuH7 cells), orthotropic tumors (from KPC cells), lung metastases (from KPC cells) of mice, and slowed growth ..
  3. Jeckel K, Bouma G, Hess A, Petrilli E, Frye M. Dietary fatty acids alter left ventricular myocardial gene expression in Wistar rats. Nutr Res. 2014;34:694-706 pubmed publisher
  4. Carter W, Vigneswara V, Newlaczyl A, Wayne D, Ahmed B, Saddington S, et al. Isoaspartate, carbamoyl phosphate synthase-1, and carbonic anhydrase-III as biomarkers of liver injury. Biochem Biophys Res Commun. 2015;458:626-631 pubmed publisher
    ..Collectively, our results suggest that elevated isoaspartate and CPS-1, and reduced CA-III levels could serve as biomarkers of hepatocellular injury. ..
  5. Caballero V, Mendieta J, Lombardo D, Saceda M, Ferragut J, Conde R, et al. Liver damage and caspase-dependent apoptosis is related to protein malnutrition in mice: effect of methionine. Acta Histochem. 2015;117:126-35 pubmed publisher
    ..The expressions of carbonic anhydrase III (CAIII), fatty acid synthase (FAS), glyceraldehyde 3-phosphate dehydrogenase (GAPDH) and glutathione S-transferase P1 (..
  6. Yang W, Shen Z, Wen S, Wang W, Hu M. Mechanisms of multiple neurotransmitters in the effects of Lycopene on brain injury induced by Hyperlipidemia. Lipids Health Dis. 2018;17:13 pubmed publisher
    ..of LDLR, NGF, GABA, 5-HT, GABAA, 5-HT1, and neuron quantities in the hippocampal CA1 and CA3 areas were lower than those in the control group (P<0.05)...
  7. Lynch C, Brennan W, Vary T, Carter N, Dodgson S. Carbonic anhydrase III in obese Zucker rats. Am J Physiol. 1993;264:E621-30 pubmed
    ..Microsequencing revealed the identity of this protein to be carbonic anhydrase III (CA III)...
  8. Wang G, Wang Y, Zheng J, Zhang L. Monoaminergic and aminoacidergic receptors are involved in the antidepressant-like effect of ginsenoside Rb1 in mouse hippocampus (CA3) and prefrontal cortex. Brain Res. 2018;1699:44-53 pubmed publisher
    ..o.) in the FST. The results obtained for the neurotransmitters in the mouse hippocampus (CA3) and prefrontal cortex showed that Rb1 up-regulated the levels of 5-HT, 5-HIAA, NE, DA, and GABA and decreased the ..
  9. Araujo G, Vaz E, Fujimura P, Fonseca J, de Lima L, Canhão H, et al. Improved serological detection of rheumatoid arthritis: a highly antigenic mimotope of carbonic anhydrase III selected in a murine model by phage display. Arthritis Res Ther. 2015;17:168 pubmed publisher
    ..The M12 peptide was identified as one that mimics a predicted antigenic site of the carbonic anhydrase III (CAIII) protein, a ubiquitous biomarker that has been identified in patients with other diseases...

More Information

Publications149 found, 100 shown here

  1. Hsu C, Lai W, Lin Y, Tain Y. Postnatal high-fat diet sex-specifically exacerbates prenatal dexamethasone-induced hypertension: Mass spectrometry-based quantitative proteomic approach. J Nutr Biochem. 2018;57:268-275 pubmed publisher
    ..In males, DEX?+?HF increased renal parvalbumin (PVALB) and carbonic anhydrase III (CA III) protein levels. While prenatal DEX down-regulated PVALB and CA III protein abundance in female offspring kidneys...
  2. Shi C, Uda Y, Dedic C, Azab E, Sun N, Hussein A, et al. Carbonic anhydrase III protects osteocytes from oxidative stress. FASEB J. 2018;32:440-452 pubmed publisher
    ..1), and Phex were among the most up-regulated known genes, whereas Srpx2, Cd200, and carbonic anhydrase III (CAIII) were identified as novel markers of differentiated osteocytes...
  3. Fernández Torre J, Burgueño P, Ballesteros M, Hernández Hernández M, Villagrá Terán N, de Lucas E. Super-refractory nonconvulsive status epilepticus secondary to fat embolism: A clinical, electrophysiological, and pathological study. Epilepsy Behav. 2015;49:184-8 pubmed publisher
    ..showing filiform neurons with reactive astrocytic gliosis background consistent with acute lesions were observed in CA3. Fat embolism should be considered a potential cause of sr-NCSE...
  4. Yoo J, Lee B, Sok D, Ma J, Kim M. Neuroprotective action of N-acetyl serotonin in oxidative stress-induced apoptosis through the activation of both TrkB/CREB/BDNF pathway and Akt/Nrf2/Antioxidant enzyme in neuronal cells. Redox Biol. 2017;11:592-599 pubmed publisher
    ..Separately, NAS at 30mg/kg suppressed scopolamine-induced memory impairment and cell death in CA1 and CA3 regions in mice...
  5. Petek L, Rickard A, Budech C, Poliachik S, Shaw D, Ferguson M, et al. A cross sectional study of two independent cohorts identifies serum biomarkers for facioscapulohumeral muscular dystrophy (FSHD). Neuromuscul Disord. 2016;26:405-13 pubmed publisher
    ..Assessing the levels of these biomarkers during clinical trials may add significance to other measures of quantifying disease progression or regression. ..
  6. Cipriani R, Chara J, Rodríguez Antigüedad A, Matute C. FTY720 attenuates excitotoxicity and neuroinflammation. J Neuroinflammation. 2015;12:86 pubmed publisher
    ..Rats were evaluated for neurological score, neuronal loss in CA3 hippocampal region and activation of microglia at the lesion site...
  7. Zhang X, Taylor A, Liu Y, Shang F. Glutathiolation triggers proteins for degradation by the ubiquitin-proteasome pathway. Curr Mol Med. 2017;: pubmed publisher
    ..Together, this work demonstrates a novel mechanism for the UPP to recognize substrates in response to oxidative stress...
  8. Wang J, Yu Z, Ren J, Xu Y, Zhang Y, Lei L, et al. Effects of pepsin A on heat shock protein 70 response in laryngopharyngeal reflux patients with chronic rhinosinusitis. Acta Otolaryngol. 2017;137:1253-1259 pubmed publisher
    ..levels in nasal tissues, and to detect pepsinogen A, HSPA5, cyclo-oxygenase-2 (COX-2), and carbonic anhydrase III (CAIII) mRNA expression levels in nasal tissues...
  9. Kinoshita Y, Hunter R, Gray J, Mesias R, McEwen B, Benson D, et al. Role for NUP62 depletion and PYK2 redistribution in dendritic retraction resulting from chronic stress. Proc Natl Acad Sci U S A. 2014;111:16130-5 pubmed publisher
    ..induces changes in the architecture and plasticity of apical dendrites that are particularly evident in the CA3 region of the hippocampus...
  10. Du C, Min A, Kim H, Shin S, Yu H, Sohn E, et al. Deer bone extract prevents against scopolamine-induced memory impairment in mice. J Med Food. 2015;18:157-65 pubmed publisher
    ..Furthermore, scopolamine-induced oxidative damage of neurons in hippocampal CA1 and CA3 regions were prevented by DBE treatment...
  11. Wood J, Hussey D, Woods C, Astill D, I Watson D, Lee B, et al. Does gene expression in laryngeal subsites differ between patients with laryngopharyngeal reflux and controls?. Clin Otolaryngol. 2018;43:158-163 pubmed publisher
    ..Whilst some of these changes may be metaplasia-related, further evaluation of the mRNA expression of these genes may provide a useful biomarker panel for diagnosis and therapeutic monitoring of LPR. ..
  12. Heine D, Sundaram S, Beudert M, Martin K, Hertweck C. A widespread bacterial phenazine forms S-conjugates with biogenic thiols and crosslinks proteins. Chem Sci. 2016;7:4848-4855 pubmed publisher
    ..Our results reveal important, yet overlooked biological roles of phenazines and show for the first time their function in protein conjugation and crosslinking. ..
  13. Min A, Doo C, Son E, Sung N, Lee K, Sok D, et al. N-palmitoyl serotonin alleviates scopolamine-induced memory impairment via regulation of cholinergic and antioxidant systems, and expression of BDNF and p-CREB in mice. Chem Biol Interact. 2015;242:153-62 pubmed publisher
    ..Moreover, Pal-5HT suppressed the death of neuronal cells in CA1 and CA3 regions, while it restored expression of p-CREB and BDNF in hippocampus...
  14. Lam C, Tipoe G, So K, Fung M. Neuroprotective mechanism of Lycium barbarum polysaccharides against hippocampal-dependent spatial memory deficits in a rat model of obstructive sleep apnea. PLoS ONE. 2015;10:e0117990 pubmed publisher
    ..CHOP) and autophagic flux in the hypoxic group, leading to neuronal apoptosis in hippocampal subfields (DG, CA1, CA3)...
  15. Sanchez Ramos J, Song S, Sava V, Catlow B, Lin X, Mori T, et al. Granulocyte colony stimulating factor decreases brain amyloid burden and reverses cognitive impairment in Alzheimer's mice. Neuroscience. 2009;163:55-72 pubmed publisher
    ..Improved cognition in AD mice was associated with increased synaptophysin immunostaining in hippocampal CA1 and CA3 regions and augmented neurogenesis, evidenced by increased numbers of calretinin-expressing cells in dentate gyrus...
  16. Raghu K, Shamprasad B, Kabekkodu S, Paladhi P, Joshi M, Valiathan M, et al. Age dependent neuroprotective effects of medhya rasayana prepared from Clitoria ternatea Linn. in stress induced rat brain. J Ethnopharmacol. 2017;197:173-183 pubmed publisher
    ..The hippocampal CA3 cellularity were increased in stereotaxic mediated stressed rats by medhya rasayana...
  17. Zhao D, Bi L, Huang Q, Zhang F, Han Z. [Isoflurane provides neuroprotection in neonatal hypoxic ischemic brain injury by suppressing apoptosis]. Rev Bras Anestesiol. 2016;66:613-621 pubmed publisher
    ..The orthodromic population spike and hypoxic injury potential were recorded in the CA1 and CA3 regions. Amino acid neurotransmitters concentration in perfusion solution of hippocampal slices was measured...
  18. Zhao D, Bi L, Huang Q, Zhang F, Han Z. Isoflurane provides neuroprotection in neonatal hypoxic ischemic brain injury by suppressing apoptosis. Braz J Anesthesiol. 2016;66:613-621 pubmed publisher
    ..The orthodromic population spike and hypoxic injury potential were recorded in the CA1 and CA3 regions. Amino acid neurotransmitters concentration in perfusion solution of hippocampal slices was measured...
  19. Sedaghat R, Taab Y, Kiasalari Z, Afshin Majd S, Baluchnejadmojarad T, Roghani M. Berberine ameliorates intrahippocampal kainate-induced status epilepticus and consequent epileptogenic process in the rat: Underlying mechanisms. Biomed Pharmacother. 2017;87:200-208 pubmed publisher
    ..Additionally, BBR protected against hippocampal CA3 neuronal loss and prevented development of aberrant mossy fiber sprouting (MFS) as an essential element of chronic ..
  20. Fujisawa H, Sugimura Y, Takagi H, Mizoguchi H, Takeuchi H, Izumida H, et al. Chronic Hyponatremia Causes Neurologic and Psychologic Impairments. J Am Soc Nephrol. 2016;27:766-80 pubmed publisher
    ..caused cognitive impairment in a novel object recognition test; and impaired long-term potentiation at hippocampal CA3-CA1 synapses...
  21. Ghisays V, Nguyen E, Streicher J, Pease N, Fitzgerald M, Estrada C, et al. Neuroanatomical Distribution of DEK Protein in Corticolimbic Circuits Associated with Learning and Memory in Adult Male and Female Mice. Neuroscience. 2018;371:254-267 pubmed publisher
    ..in all amygdalar subdivisions (basolateral, central and medial) and in the hippocampus including the CA1, CA2, CA3, dentate gyrus (DG), ventral subiculum and entorhinal cortex...
  22. Novick A, Mears M, Forster G, Lei Y, Tejani Butt S, Watt M. Adolescent social defeat alters N-methyl-D-aspartic acid receptor expression and impairs fear learning in adulthood. Behav Brain Res. 2016;304:51-9 pubmed publisher
    ..in the infralimbic region of the prefrontal cortex and central amygdala, while increasing expression in the CA3 region of the hippocampus...
  23. Itakura M, Nakajima H, Kubo T, Semi Y, Kume S, Higashida S, et al. Glyceraldehyde-3-phosphate Dehydrogenase Aggregates Accelerate Amyloid-β Amyloidogenesis in Alzheimer Disease. J Biol Chem. 2015;290:26072-87 pubmed publisher
    ..co-incubated with GAPDH aggregates exhibited Aβ40-induced pyramidal cell death and gliosis in the hippocampal CA3 region...
  24. Chawla A, Cordner Z, Boersma G, Moran T. Cognitive impairment and gene expression alterations in a rodent model of binge eating disorder. Physiol Behav. 2017;180:78-90 pubmed publisher
    ..the NOR deficits were correlated with reductions in the expression of TrkB and insulin receptor (Ir) in the CA3 region of the hippocampus...
  25. Martin E, Muralidhar S, Wang Z, Cervantes D, Basu R, Taylor M, et al. The intellectual disability gene Kirrel3 regulates target-specific mossy fiber synapse development in the hippocampus. elife. 2015;4:e09395 pubmed publisher
    ..synapse formation at hippocampal mossy fiber (MF) synapses, which connect dentate granule (DG) neurons to both CA3 and GABAergic neurons...
  26. Salami P, Lévesque M, Avoli M. High frequency oscillations can pinpoint seizures progressing to status epilepticus. Exp Neurol. 2016;280:24-9 pubmed publisher
    ..Here, we analyzed the EEG signals recorded from the CA3 region of the hippocampus and the entorhinal cortex in rats that responded to systemic administration of 4-..
  27. Lebois E, Trimper J, Hu C, Levey A, Manns J. Effects of Selective M1 Muscarinic Receptor Activation on Hippocampal Spatial Representations and Neuronal Oscillations. ACS Chem Neurosci. 2016;7:1393-1405 pubmed
    ..Hippocampal pyramidal neuron spiking and local field potentials were recorded from regions CA1 and CA3 as rats freely foraged in a recording enclosure...
  28. Chen X, Tolkovsky A, Herbert J. Cell origin and culture history determine successful integration of neural precursor transplants into the dentate gyrus of the adult rat. PLoS ONE. 2011;6:e17072 pubmed publisher
    ..cells at 6 weeks), substantially repaired the damaged DG, and formed glutamatergic projections to the target CA3 region...
  29. Delprato A, Bonheur B, Algéo M, Rosay P, Lu L, Williams R, et al. Systems genetic analysis of hippocampal neuroanatomy and spatial learning in mice. Genes Brain Behav. 2015;14:591-606 pubmed publisher
    ..Data were collected on seven hippocampal subregions in CA3 and CA4 after testing spatial memory in an eight-arm radial maze task...
  30. Melo I, Santos Y, Costa M, Pacheco A, Silva N, Cardoso Sousa L, et al. Inhibition of sodium glucose cotransporters following status epilepticus induced by intrahippocampal pilocarpine affects neurodegeneration process in hippocampus. Epilepsy Behav. 2016;61:258-268 pubmed publisher
    ..The PZN+PILO animals had a higher (p<0.05) number of FJ-C+ cells in the dentate gyrus (DG), hilus, and CA3 and CA1 of hippocampus, when compared with VEH+PILO. The PZN+PILO animals had a decreased number (p<0...
  31. Zhang J, Jing Y, Zhang H, Bilkey D, Liu P. Maternal immune activation leads to increased nNOS immunoreactivity in the brain of postnatal day 2 rat offspring. Synapse. 2018;72: pubmed publisher
    ..Immunohistochemistry revealed a markedly increased intensity of nNOS-positive cells in the CA3 and dentate gyrus subregions of the hippocampus, the somatosensory cortex, and the striatum, but not the frontal ..
  32. Alexander T, Simecka C, Kiffer F, Groves T, Anderson J, Carr H, et al. Changes in cognition and dendritic complexity following intrathecal methotrexate and cytarabine treatment in a juvenile murine model. Behav Brain Res. 2018;346:21-28 pubmed publisher
    ..compromised the dendritic architecture and reduced mushroom spine density in the dorsal ganglion (DG), CA1, and CA3 areas of the hippocampus...
  33. Severa W, Parekh O, James C, Aimone J. A Combinatorial Model for Dentate Gyrus Sparse Coding. Neural Comput. 2017;29:94-117 pubmed publisher
    The dentate gyrus forms a critical link between the entorhinal cortex and CA3 by providing a sparse version of the signal...
  34. Pecoraro V, Sardone L, Chisari M, Licata F, Li Volsi G, Perciavalle V, et al. A subnanomolar concentration of Pituitary Adenylate Cyclase-Activating Polypeptide (PACAP) pre-synaptically modulates glutamatergic transmission in the rat hippocampus acting through acetylcholine. Neuroscience. 2017;340:551-562 pubmed publisher
    ..on stimulation-evoked AMPA receptor-mediated excitatory post-synaptic currents (EPSCsAMPA) in the CA3-CA1 synapse and on spontaneous miniature EPSCs (mEPSCs) in CA1 pyramidal neurons. A subnanomolar dose of PACAP (0...
  35. Godoy L, Liberato J, Celani M, Gobbo Neto L, Lopes N, dos Santos W. Disease Modifying Effects of the Spider Toxin Parawixin2 in the Experimental Epilepsy Model. Toxins (Basel). 2017;9: pubmed publisher
    ..recurrent seizures (SRS), (b) neuronal loss, and (c) PV cell density in different regions of the hippocampus (CA1, CA3, DG and Hilus). (3) Results: Parawixin2 treatment reduced SRS frequency whereas Tiagabine did not...
  36. Panther P, Nullmeier S, Dobrowolny H, Schwegler H, Wolf R. CPB-K mice a mouse model of schizophrenia? Differences in dopaminergic, serotonergic and behavioral markers compared to BALB/cJ mice. Behav Brain Res. 2012;230:215-28 pubmed
    ..of raphe nuclei and a lower serotonergic fiber density in the ventral and dorsal hippocampal subfields CA1 and CA3, (3) no alterations of dopaminergic markers like neuron number, neuron density and volume in subregions of ..
  37. Dai J, Wang S, Shan D, Niu H, Lei H. Super-Resolution Track-Density Imaging Reveals Fine Anatomical Features in Tree Shrew Primary Visual Cortex and Hippocampus. Neurosci Bull. 2018;34:438-448 pubmed publisher
    ..bands in the primary visual cortex and the longitudinal component of the mossy fibers within the hippocampal CA3 subfield, were observable with stTDI, but not with DTI reconstructions from the same dMRI data...
  38. Tang W, Tam J, Seah C, Chiu J, Tyrer A, Cregan S, et al. Arf6 controls beta-amyloid production by regulating macropinocytosis of the Amyloid Precursor Protein to lysosomes. Mol Brain. 2015;8:41 pubmed publisher
    ..disease, being expressed mostly in the CA1 and CA2 regions in normal individuals but spreading through the CA3 and CA4 regions in individuals with pathologically diagnosed AD...
  39. Shi Q, Colodner K, Matousek S, Merry K, Hong S, Kenison J, et al. Complement C3-Deficient Mice Fail to Display Age-Related Hippocampal Decline. J Neurosci. 2015;35:13029-42 pubmed publisher
    ..synapse loss in aged WT mice that was not observed in C3 KO mice; (2) age-dependent neuron loss in hippocampal CA3 (but not in CA1) that followed synapse loss in aged WT mice, neither of which were observed in aged C3 KO mice; and ..
  40. Ghosh R, Barman S, Mukherjee R, Mandal N. Role of phosphate solubilizing Burkholderia spp. for successful colonization and growth promotion of Lycopodium cernuum L. (Lycopodiaceae) in lateritic belt of Birbhum district of West Bengal, India. Microbiol Res. 2016;183:80-91 pubmed publisher
    ..Day wise kinetics of phosphate solubilization against Ca3(PO4)2 suggested P4 (580.56±13.38 μg ml(-1)) as maximum mineral phosphate solubilizer followed by P9 (517...
  41. Sadowski J, Jones M, Mellor J. Sharp-Wave Ripples Orchestrate the Induction of Synaptic Plasticity during Reactivation of Place Cell Firing Patterns in the Hippocampus. Cell Rep. 2016;14:1916-29 pubmed publisher
    ..Here, we show that reactivated place cell firing patterns simultaneously recorded from CA3 and CA1 of rat dorsal hippocampus are able to induce long-term potentiation (LTP) at synapses between CA3 and CA1 ..
  42. Fischer W, Franke H, Krügel U, Muller H, Dinkel K, Lord B, et al. Critical Evaluation of P2X7 Receptor Antagonists in Selected Seizure Models. PLoS ONE. 2016;11:e0156468 pubmed publisher
    ..and JNJ-47965567-treated animals displayed strongly reduced Iba 1 and GFAP immunoreactivity in the hippocampal CA3 region...
  43. Shimshek D, Bus T, Schupp B, Jensen V, Marx V, Layer L, et al. Different Forms of AMPA Receptor Mediated LTP and Their Correlation to the Spatial Working Memory Formation. Front Mol Neurosci. 2017;10:214 pubmed publisher
    Spatial working memory (SWM) and the classical, tetanus-induced long-term potentiation (LTP) at hippocampal CA3/CA1 synapses are dependent on L-?-amino-3-hydroxy-5-methylisoxazole-4-propionate receptors (AMPARs) containing GluA1 subunits ..
  44. Kourdougli N, Varpula S, Chazal G, Rivera C. Detrimental effect of post Status Epilepticus treatment with ROCK inhibitor Y-27632 in a pilocarpine model of temporal lobe epilepsy. Front Cell Neurosci. 2015;9:413 pubmed publisher
    ..demonstrate that a systemic administration of Y-27632 in pilocarpine-treated rats increases neuronal death in the CA3 region and ectopic recurrent mossy fiber sprouting (rMFS) in the dentate gyrus of the hippocampal formation...
  45. Lisman J. Glutamatergic synapses are structurally and biochemically complex because of multiple plasticity processes: long-term potentiation, long-term depression, short-term potentiation and scaling. Philos Trans R Soc Lond B Biol Sci. 2017;372: pubmed publisher
    ..ii) The rules for long-term potentiation (LTP) induction in CA3 have been clarified: induction does not depend obligatorily on backpropagating sodium spikes but, rather, on ..
  46. Ribeiro M, Bezerra T, Soares A, Boechat Ramos R, Carneiro F, Vianna L, et al. Hippocampal and cerebellar histological changes and their behavioural repercussions caused by brain ischaemic hypoxia experimentally induced by sodium nitrite. Behav Brain Res. 2017;332:223-232 pubmed publisher
    ..neurons with lesions was significantly higher in animals exposed to NaNO2 in the hippocampus areas CA2, CA3, and CA4. The cerebellum was also very vulnerable to hypoxia, presenting extensive lesion áreas...
  47. Ruff C, Faulkner S, Rumajogee P, Beldick S, Foltz W, Corrigan J, et al. The extent of intrauterine growth restriction determines the severity of cerebral injury and neurobehavioural deficits in rodents. PLoS ONE. 2017;12:e0184653 pubmed publisher
    ..NeuN staining revealed changes in neuronal density in the hippocampus and in the thickness of hippocampal CA2 and CA3 regions. Diffusion weighted imaging (DWI) revealed regional white and grey matter changes at 3 weeks of age...
  48. Sieu L, Eugène E, Bonnot A, Cohen I. Disrupted Co-activation of Interneurons and Hippocampal Network after Focal Kainate Lesion. Front Neural Circuits. 2017;11:87 pubmed publisher
    ..by in vitro recording of extracellular potentials and patch-clamp from GFP-expressing interneurons in CA3, in an optimized recording chamber...
  49. Wang X, Li J, Xie M, Qu L, Zhang P, Li X. Structure, mechanical property and corrosion behaviors of (HA+β-TCP)/Mg-5Sn composite with interpenetrating networks. Mater Sci Eng C Mater Biol Appl. 2015;56:386-92 pubmed publisher
    ..The corrosion products on the composite surface are mainly Mg(OH)2, Ca3(PO4)2 and HA...
  50. Stagni F, Raspanti A, Giacomini A, Guidi S, Emili M, Ciani E, et al. Long-term effect of neonatal inhibition of APP gamma-secretase on hippocampal development in the Ts65Dn mouse model of Down syndrome. Neurobiol Dis. 2017;103:11-23 pubmed publisher
    ..granule neurons were still restored as was the number of pre- and postsynaptic terminals in the stratum lucidum of CA3, the site of termination of the mossy fibers from the DG...
  51. Dutton S, Dutt K, Papale L, Helmers S, Goldin A, Escayg A. Early-life febrile seizures worsen adult phenotypes in Scn1a mutants. Exp Neurol. 2017;293:159-171 pubmed publisher
    ..Biophysical analysis of brain slice preparations revealed an increase in epileptiform activity in CA3 pyramidal neurons along with increased action potential firing, providing a mechanistic basis for the observed ..
  52. Carasatorre M, Ochoa Alvarez A, Velázquez Campos G, Lozano Flores C, Ramírez Amaya V, Díaz Cintra S. Hippocampal Synaptic Expansion Induced by Spatial Experience in Rats Correlates with Improved Information Processing in the Hippocampus. PLoS ONE. 2015;10:e0132676 pubmed publisher
    ..treatments also enhance network reliability and improve partial pattern separation in CA1 and pattern completion in CA3. By measuring the area occupied by synaptophysin staining in both the stratum oriens and the stratun lucidum of the ..
  53. Ekova M, Smirnov A, Schmidt M, Tyurenkov I, Volotova E, Kurkin D, et al. [COMPARATIVE MORPHOFUNCTIONAL CHARACTERISTICS OF ADULT AND OLD RAT VENTRAL HIPPOCAMPUS TO COMBINED STRESS INFLUENCE]. Adv Gerontol. 2016;29:59-67 pubmed
    ..marked dystrophic changes and increased inducible nitric oxide synthase expression in pyramidal neurons of CA3 field, signs of impaired hemodynamic disorders in the microvasculature, perivascular edema, decreased endothelial ..
  54. Hooper A, Fuller P, Maguire J. Hippocampal corticotropin-releasing hormone neurons support recognition memory and modulate hippocampal excitability. PLoS ONE. 2018;13:e0191363 pubmed publisher
    ..Conversely, selective activation of CRH neurons in vitro suppressed the excitability of the mossy fiber-CA3 pathway...
  55. Morales Medina J, Iannitti T, Freeman A, Caldwell H. The olfactory bulbectomized rat as a model of depression: The hippocampal pathway. Behav Brain Res. 2017;317:562-575 pubmed publisher
    ..the hippocampus, including decreases in dentate gyrus neurogenesis, disruption in long-term potentiation in CA1 and CA3 subregions and neuronal atrophy in the CA1 subregion, along with downstream markers, all of which are consistent ..
  56. Zheng F. TRPC Channels and Epilepsy. Adv Exp Med Biol. 2017;976:123-135 pubmed publisher
    ..The reduction of spontaneous epileptiform bursting in the CA3 is correlated to a reduction in pilocarpine-induced SE in vivo in TRPC7 knockout mice...
  57. Papatheodoropoulos C. Higher intrinsic network excitability in ventral compared with the dorsal hippocampus is controlled less effectively by GABAB receptors. BMC Neurosci. 2015;16:75 pubmed publisher
    ..e. disinhibition). Using field recordings from the CA3 and CA1 fields of hippocampal slices from adult rats I found that ventral compared with dorsal hippocampus slices ..
  58. Norris C, Sompol P, Roberts K, Ansari M, Scheff S. Pycnogenol protects CA3-CA1 synaptic function in a rat model of traumatic brain injury. Exp Neurol. 2016;276:5-12 pubmed publisher
    ..Here, we investigated the effects of PYC on CA3-CA1 synaptic function following CCI...
  59. Hollands C, Tobin M, Hsu M, Musaraca K, Yu T, Mishra R, et al. Depletion of adult neurogenesis exacerbates cognitive deficits in Alzheimer's disease by compromising hippocampal inhibition. Mol Neurodegener. 2017;12:64 pubmed publisher
    ..Interestingly, we observed upregulation of the immediate early gene Zif268 (Egr-1) in the dentate gyrus, CA1 and CA3 regions of the hippocampus following learning in the neurogenesis-depleted ?-HSV-TK mice...
  60. Zhao X, Wu Q, Peng J, Pan L, Ren Z, Liu H, et al. Hyperlipidemia-induced apoptosis of hippocampal neurons in apoE(-/-) mice may be associated with increased PCSK9 expression. Mol Med Rep. 2017;15:712-718 pubmed publisher
    ..secretase 1 (BACE1), B?cell lymphoma 2 (Bcl?2), Bcl?2?associated X protein (Bax), and caspase?3 in hippocampal CA3 and CA1 neurons were also measured...
  61. Jalayeri Darbandi Z, Rajabzadeh A, Hosseini M, Beheshti F, Ebrahimzadeh Bideskan A. The effect of methamphetamine exposure during pregnancy and lactation on hippocampal doublecortin expression, learning and memory of rat offspring. Anat Sci Int. 2018;93:351-363 pubmed publisher
    ..during pregnancy was found to have significantly decreased the number of DCX-positive cells in the CA1, CA3 and DG regions of the hippocampus in the 1-day pups (P ? 0...
  62. Chawla M, Sutherland V, Olson K, McNaughton B, Barnes C. Behavior-driven Arc expression is reduced in all ventral hippocampal subfields compared to CA1, CA3 and dentate gyrus in rat dorsal hippocampus. Hippocampus. 2017;: pubmed publisher
    ..We report here, that Arc is expressed in a greater proportion of cells in dorsal CA1, CA3 and dentate gyrus (DG), following spatial behavioral experiences compared to ventral hippocampal subregions (dorsal ..
  63. Bass D, Manns J. Memory-enhancing amygdala stimulation elicits gamma synchrony in the hippocampus. Behav Neurosci. 2015;129:244-56 pubmed publisher
    ..Stimulation also elicited field-field and spike-field CA3-CA1 synchrony in the hippocampus in the low gamma frequency range (30-55 Hz), a range previously associated with ..
  64. Reyes Mendoza J, Morales T. Post-treatment with prolactin protects hippocampal CA1 neurons of the ovariectomized female rat against kainic acid-induced neurodegeneration. Neuroscience. 2016;328:58-68 pubmed publisher
    ..we reported that pre-treatment with prolactin (PRL) prevents the neuron loss induced by KA administration in CA1, CA3 and CA4 of the hippocampus of the female rat...
  65. Sunkaria A, Yadav A, Bhardwaj S, Sandhir R. Postnatal Proteasome Inhibition Promotes Amyloid-? Aggregation in Hippocampus and Impairs Spatial Learning in Adult Mice. Neuroscience. 2017;367:47-59 pubmed publisher
    ..substantial loss of cellular connections, distorted architecture and increased pyknosis in hippocampal CA1 and CA3 regions of MG132 mice...
  66. Unal G, Crump M, Viney T, Éltes T, Katona L, Klausberger T, et al. Spatio-temporal specialization of GABAergic septo-hippocampal neurons for rhythmic network activity. Brain Struct Funct. 2018;223:2409-2432 pubmed publisher
    ..We demonstrate the preferential innervation of bistratified cells in CA1 and of basket cells in CA3 by individual axons...
  67. Azzazy H, Cummings P, Ambrozak D, Christenson R. Production and characterization of monoclonal antibodies to human carbonic anhydrase III. Hybridoma. 1998;17:553-8 pubmed
    Carbonic anhydrase III (CAIII) is a cytosolic protein found almost exclusively in slow-oxidative skeletal muscle fibers. Upon excessive skeletal muscle activity or damage, CAIII is rapidly released into serum...
  68. Kim S, Yang C, Powers T, Davis L, Lou X, Gordon R. Synthesis of Calcium(II) Amidinate Precursors for Atomic Layer Deposition through a Redox Reaction between Calcium and Amidines. Angew Chem Int Ed Engl. 2016;55:10228-33 pubmed publisher
    ..unprecedentedly high volatility as compared to the widely employed and commercially available Ca(II) precursor, [Ca3 (tmhd)6 ]...
  69. Kyyriäinen J, Ekolle Ndode Ekane X, Pitkänen A. Dynamics of PDGFRβ expression in different cell types after brain injury. Glia. 2017;65:322-341 pubmed publisher
    ..05) and in CA3 (201% at seventh day, P < 0.05), but the total number of PDGFRβ+ cells was not altered...
  70. Reynolds A, Saunders M, Berry J, Sharrett Field L, Winchester S, Prendergast M. Broad-spectrum protein kinase inhibition by the staurosporine analog KT-5720 reverses ethanol withdrawal-associated loss of NeuN/Fox-3. Alcohol. 2017;64:37-43 pubmed publisher
    ..loss of NeuN/Fox-3 IF in pyramidal CA1 and granule DG cell layers produced by CIE, but there was no restoration in CA3. Application of KT-5720 during EWD failed to significantly alter levels of NeuN IF, implying that ethanol exposure ..
  71. Fan Y, Kong H, Ye X, Ding J, Hu G. ATP-sensitive potassium channels: uncovering novel targets for treating depression. Brain Struct Funct. 2016;221:3111-22 pubmed publisher
    ..behaviors under non-stress conditions, but aggravated depressive behaviors accompanied by the loss of CA3 neuron and the reduction of brain-derived neurotrophic factor in hippocampus under chronic stress...
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    ..CO revealed involvement of the prefrontal and parietal cortices, dorsal and ventral striatum, CA1 and CA3 subfields of the dorsal hippocampus, basolateral and lateral amygdala, and mammillary nuclei in the PC group, ..
  73. Eguchi N, Hishimoto A, Sora I, Mori M. Slow synaptic transmission mediated by TRPV1 channels in CA3 interneurons of the hippocampus. Neurosci Lett. 2016;616:170-6 pubmed publisher
    ..To study this possibility further, we recorded mGluR-induced synaptic responses in the interneurons of the CA3 stratum radiatum using rat hippocampal organotypic slice cultures...
  74. Yap K, Shetty M, Garcia Alvarez G, Lu B, Alagappan D, Oh Hora M, et al. STIM2 regulates AMPA receptor trafficking and plasticity at hippocampal synapses. Neurobiol Learn Mem. 2017;138:54-61 pubmed publisher
    ..We found that STIM2 is required for the stable expression of both LTP and LTD at CA3-CA1 hippocampal synapses...
  75. Smirnov A, Tyurenkov I, Shmidt M, Ekova M, Mednikov D, Borodin D. Effect of Combined Stress on Morphological Changes and Expression of NO Synthases in Rat Ventral Hippocampus. Bull Exp Biol Med. 2015;160:96-9 pubmed publisher
    ..bed, perivascular edema, pronounced degenerative changes, and enhanced expression of inducible NO synthase in CA3 pyramidal neurons in the ventral hippocampus of stressed 12-month-old rats were observed...
  76. Tamano H, Koike Y, Nakada H, Shakushi Y, Takeda A. Significance of synaptic Zn2+ signaling in zincergic and non-zincergic synapses in the hippocampus in cognition. J Trace Elem Med Biol. 2016;38:93-98 pubmed publisher
    ..At mossy fiber-CA3 pyramidal cell synapses and Schaffer collateral-CA1 pyramidal cell synapses, which are zincergic, extracellular Zn<..
  77. Aboutaleb N, Shamsaei N, Khaksari M, Erfani S, Rajabi H, Nikbakht F. Pre-ischemic exercise reduces apoptosis in hippocampal CA3 cells after cerebral ischemia by modulation of the Bax/Bcl-2 proteins ratio and prevention of caspase-3 activation. J Physiol Sci. 2015;65:435-43 pubmed publisher
    ..This study investigated the effects of pre-ischemic exercise on CA3 neurons. Rats were divided into three groups. Animals in the exercise group were trained 5 days a week for 4 weeks...
  78. Oosterhof C, El Mansari M, Bundgaard C, Blier P. Brexpiprazole Alters Monoaminergic Systems following Repeated Administration: an in Vivo Electrophysiological Study. Int J Neuropsychopharmacol. 2015;19:pyv111 pubmed publisher
    ..dorsal raphe nucleus, dopaminergic neurons in the ventral tegmental area, and pyramidal neurons in the hippocampus CA3 region were obtained in adult male Sprague-Dawley rats under chloral hydrate anesthesia within 4 hours after final ..
  79. Pleiss M, Sompol P, Kraner S, Abdul H, Furman J, Guttmann R, et al. Calcineurin proteolysis in astrocytes: Implications for impaired synaptic function. Biochim Biophys Acta. 2016;1862:1521-32 pubmed publisher
    ..astrocytes of intact rats (using adeno-associated virus), we observed a significant reduction in the strength of CA3-CA1 excitatory synapses, indicating that the hyperactivation of astrocytic calcineurin is sufficient for disrupting ..
  80. Mehta V, Parashar A, Sharma A, Singh T, Udayabanu M. Quercetin ameliorates chronic unpredicted stress-mediated memory dysfunction in male Swiss albino mice by attenuating insulin resistance and elevating hippocampal GLUT4 levels independent of insulin receptor expression. Horm Behav. 2017;89:13-22 pubmed publisher
    ..induced significant cognitive dysfunction (NOR and MWM) and severely damaged hippocampal neurons, especially in the CA3 region. Quercetin treatment alleviated memory dysfunction and rescued neurons from CUS-mediated damage...
  81. Zamorano C, Fernández Albert J, Storm D, Carne X, Sindreu C. Memory Retrieval Re-Activates Erk1/2 Signaling in the Same Set of CA1 Neurons Recruited During Conditioning. Neuroscience. 2018;370:101-111 pubmed publisher
    ..kinase (Erk1/2) across neuronal populations of the hippocampus to find that CA1 pyramidal neurons, but not cells in CA3 or dentate gyrus, specifically respond to retrieval of an aversive context...
  82. Scharfman H, MacLusky N. Sex differences in hippocampal area CA3 pyramidal cells. J Neurosci Res. 2017;95:563-575 pubmed publisher
    ..Here we review basic studies of male and female structure, function, and plasticity of area CA3 pyramidal cells of adult rats...
  83. Rolls E. A scientific theory of Ars Memoriae: Spatial view cells in a continuous attractor network with linked items. Hippocampus. 2017;27:570-579 pubmed publisher
    ..The new theory is proposed that this type of memory is implemented in the CA3 region of the hippocampus where there are spatial view cells in primates that allow a particular view to be ..
  84. Farar V, Valuskova P, Ševčíková M, Myslivecek J, Slamberova R. Mapping of the prenatal and postnatal methamphetamine effects on D1-like dopamine, M1 and M2 muscarinic receptors in rat central nervous system. Brain Res Bull. 2018;137:17-22 pubmed publisher
    ..M1MR were decreased in caudate-putamen, dorsal hippocampus, CA1, CA3 and dentate gyrus (DG). M2MR were decreased in DG only...
  85. Scholler P, Nevoltris D, De Bundel D, Bossi S, Moreno Delgado D, Rovira X, et al. Allosteric nanobodies uncover a role of hippocampal mGlu2 receptor homodimers in contextual fear consolidation. Nat Commun. 2017;8:1967 pubmed publisher
    ..PAMs enhance the inhibitory action of the orthosteric mGlu2/mGlu3 agonist, DCG-IV, at mossy fiber terminals in the CA3 region of hippocampal slices...
  86. Shan W, Nagai T, Tanaka M, Itoh N, Furukawa Hibi Y, Nabeshima T, et al. Neuronal PAS domain protein 4 (Npas4) controls neuronal homeostasis in pentylenetetrazole-induced epilepsy through the induction of Homer1a. J Neurochem. 2018;145:19-33 pubmed publisher
    ..PTZ reduced excitatory synaptic transmission at the associational/commissural fibers-CA3 synapses through the Npas4-mediated down-regulation of postsynaptic α-amino-3-hydroxy-5-methyl-4-..
  87. Nogradi A, Kelly C, Carter N. Localization of acetazolamide-resistant carbonic anhydrase III in human and rat choroid plexus by immunocytochemistry and in situ hybridisation. Neurosci Lett. 1993;151:162-5 pubmed
    ..Since the kinetic properties and proportion of brain carbonic anhydrase III in the human choroid plexus are not revealed the function of this isozyme in choroid plexus is still to be determined. ..
  88. Soares L, De Vry J, Steinbusch H, Milani H, Prickaerts J, Weffort de Oliveira R. Rolipram improves cognition, reduces anxiety- and despair-like behaviors and impacts hippocampal neuroplasticity after transient global cerebral ischemia. Neuroscience. 2016;326:69-83 pubmed publisher
    ..BCCAO caused neuronal loss in the CA3 hippocampal subfield and basolateral amygdala (BLA)...
  89. Leal S, Noche J, Murray E, Yassa M. Age-related individual variability in memory performance is associated with amygdala-hippocampal circuit function and emotional pattern separation. Neurobiol Aging. 2017;49:9-19 pubmed publisher
    ..high performers: HP). We found signals consistent with emotional pattern separation in hippocampal dentate (DG)/CA3 in HP but not in LP individuals, suggesting a deficit in emotional pattern separation...
  90. Szabó G, Du X, Oijala M, Varga C, Parent J, Soltesz I. Extended Interneuronal Network of the Dentate Gyrus. Cell Rep. 2017;20:1262-1268 pubmed publisher
    ..Here, we use the case of the dentate gyrus (DG) to show that boundary-crossing interneurons with cell bodies in CA3 and CA1 constitute a numerically significant and diverse population that relays patterns of activity generated ..
  91. Nguyen E, Caldwell J, Streicher J, Ghisays V, Balmer N, Estrada C, et al. Differential effects of imipramine and CORT118335 (Glucocorticoid receptor modulator/mineralocorticoid receptor antagonist) on brain-endocrine stress responses and depression-like behavior in female rats. Behav Brain Res. 2018;336:99-110 pubmed publisher
    ..Imipramine decreased c-Fos in the basolateral amygdala and hippocampus (CA1 and CA3), but increased c-Fos in the central amygdala. These data suggest the antidepressant-like (e.g...
  92. Zhu C, Xu Q, Wang C, Mao Z, Lin N. Evidence that CA3 is Underling the Comorbidity Between Pain and Depression and the Co-curation by Wu-Tou decoction in Neuropathic Pain. Sci Rep. 2017;7:11935 pubmed publisher
    ..Moreover, we reported that WTD rescued the mal-regulated BDNF and TNF-? in hippocampal CA3 alone, which is proven contributing to the pain and induced psychiatric symptoms...