beta-catenin

Summary

Gene Symbol: beta-catenin
Description: catenin beta 1
Alias: CTNNB, EVR7, MRD19, armadillo, catenin beta-1, catenin (cadherin-associated protein), beta 1, 88kDa
Species: human
Products:     beta-catenin

Top Publications

  1. Yu B, Yang X, Xu Y, Yao G, Shu H, Lin B, et al. Elevated expression of DKK1 is associated with cytoplasmic/nuclear beta-catenin accumulation and poor prognosis in hepatocellular carcinomas. J Hepatol. 2009;50:948-57 pubmed publisher
    ..Elevated expression of DKK1 is a critical event in patients with HCC that indicates poor clinical outcome. DKK1, alone or combined with beta-catenin, is a novel prognostic predictor for HCC patients. ..
  2. Crampton S, Wu B, Park E, Kim J, Solomon C, Waterman M, et al. Integration of the beta-catenin-dependent Wnt pathway with integrin signaling through the adaptor molecule Grb2. PLoS ONE. 2009;4:e7841 pubmed publisher
    ..These data suggest that integrin ligation and FAK activation synergize with wnt signaling through a Grb2-rac-jnk-c-jun pathway, providing a context-dependent mechanism for modulation of wnt signaling. ..
  3. Liu Y, Dong Q, Wang S, Xu H, Miao Y, Wang L, et al. Kaiso interacts with p120-catenin to regulate ?-catenin expression at the transcriptional level. PLoS ONE. 2014;9:e87537 pubmed publisher
    ..Based on these results, we concluded that Kaiso participates in the regulation by p120ctn of ?-catenin mRNA expression in the lung cancer cell lines. ..
  4. Nollet F, Berx G, Molemans F, van Roy F. Genomic organization of the human beta-catenin gene (CTNNB1). Genomics. 1996;32:413-24 pubmed
    ..The intron-exon boundaries did not coincide either with conserved sites in the 12 armadillo repeat sequences of beta-catenin or with intron-exon boundaries in the armadillo gene of Drosophila...
  5. Yamamoto H, Kishida S, Uochi T, Ikeda S, Koyama S, Asashima M, et al. Axil, a member of the Axin family, interacts with both glycogen synthase kinase 3beta and beta-catenin and inhibits axis formation of Xenopus embryos. Mol Cell Biol. 1998;18:2867-75 pubmed
    ..These results indicate that Axil negatively regulates the Wnt signaling pathway by mediating GSK-3beta-dependent phosphorylation of beta-catenin, thereby inhibiting axis formation. ..
  6. Liu J, Stevens J, Rote C, Yost H, Hu Y, Neufeld K, et al. Siah-1 mediates a novel beta-catenin degradation pathway linking p53 to the adenomatous polyposis coli protein. Mol Cell. 2001;7:927-36 pubmed
    ..These results indicate that APC and Siah-1 mediate a novel beta-catenin degradation pathway linking p53 activation to cell cycle control. ..
  7. Li Q, Dashwood R. Activator protein 2alpha associates with adenomatous polyposis coli/beta-catenin and Inhibits beta-catenin/T-cell factor transcriptional activity in colorectal cancer cells. J Biol Chem. 2004;279:45669-75 pubmed
    ..and the AP-2alpha binding site was identified in the N terminus of APC, involving both the heptad and armadillo repeat domains, whereas the APC binding site in AP-2alpha was in the basic region of the C-terminal DNA binding ..
  8. Tadjine M, Lampron A, Ouadi L, Horvath A, Stratakis C, Bourdeau I. Detection of somatic beta-catenin mutations in primary pigmented nodular adrenocortical disease (PPNAD). Clin Endocrinol (Oxf). 2008;69:367-73 pubmed publisher
    ..We hypothesized that adrenocortical adenomas that form in the context of PPNAD may harbour beta-catenin mutations...
  9. Zhurinsky J, Shtutman M, Ben Ze ev A. Differential mechanisms of LEF/TCF family-dependent transcriptional activation by beta-catenin and plakoglobin. Mol Cell Biol. 2000;20:4238-52 pubmed
    ..Removal of the N- and C-terminal domains of both beta-catenin and plakoglobin (leaving the armadillo repeat domain intact) induced plakoglobin-LEF-DNA complex formation and also enhanced beta-catenin-LEF-DNA ..

More Information

Publications384 found, 100 shown here

  1. Zhao X, Li H, Chen H, Liu Y, Zhang L, Liu S, et al. Expression of e-cadherin and beta-catenin in human esophageal squamous cell carcinoma: relationships with prognosis. World J Gastroenterol. 2003;9:225-32 pubmed
    ..As a probable independent prognostic factor, it correlates with overall and disease free survival period, expression of E-cadherin but not beta-catenin may predict prognosis in patients with ESCC. ..
  2. Coluccia A, Vacca A, Duñach M, Mologni L, Redaelli S, Bustos V, et al. Bcr-Abl stabilizes beta-catenin in chronic myeloid leukemia through its tyrosine phosphorylation. EMBO J. 2007;26:1456-66 pubmed
    ..These findings indicate the Bcr-Abl triggered Y phosphorylation of beta-catenin as a new mechanism responsible for its protein stabilization and nuclear signalling activation in CML. ..
  3. Saha A, Deshaies R. Multimodal activation of the ubiquitin ligase SCF by Nedd8 conjugation. Mol Cell. 2008;32:21-31 pubmed publisher
  4. Arozarena I, Bischof H, Gilby D, Belloni B, Dummer R, Wellbrock C. In melanoma, beta-catenin is a suppressor of invasion. Oncogene. 2011;30:4531-43 pubmed publisher
    ..Thus our study reveals the general importance of considering cell-type-specific signalling for the accurate interpretation of tumour markers and ultimately for the design of rational therapies. ..
  5. Sacco P, McGranahan T, Wheelock M, Johnson K. Identification of plakoglobin domains required for association with N-cadherin and alpha-catenin. J Biol Chem. 1995;270:20201-6 pubmed
    ..Plakoglobin is an armadillo family member containing 13 weakly similar internal repeats...
  6. Ashihara K, Saito T, Mizumoto H, Nishimura M, Tanaka R, Kudo R. Mutation of beta-catenin gene in endometrial cancer but not in associated hyperplasia. Med Electron Microsc. 2002;35:9-15 pubmed
    ..The results suggest that molecular alteration of the beta-catenin gene occurs in atypical hyperplasia or cancer, rather than in simple or complex hyperplasia without atypia, during endometrial carcinogenesis. ..
  7. Kohler E, Brauburger K, Behrens J, Schneikert J. Contribution of the 15 amino acid repeats of truncated APC to beta-catenin degradation and selection of APC mutations in colorectal tumours from FAP patients. Oncogene. 2010;29:1663-71 pubmed publisher
    ..The analysis of the distribution of truncating mutations along the APC sequence in colorectal tumours from FAP patients revealed that the first 15R is one target of the positive selection of mutations that lead to tumour development...
  8. Hsu R, Ho J, Cha T, Yu D, Wu C, Huang W, et al. WNT10A plays an oncogenic role in renal cell carcinoma by activating WNT/?-catenin pathway. PLoS ONE. 2012;7:e47649 pubmed publisher
    ..In conclusion, we showed that WNT10A acts as an autocrine oncogene both in RCC carcinogenesis and progression by activating WNT/?-catenin signaling. ..
  9. Colombo C, Miceli R, Lazar A, Perrone F, Pollock R, Le Cesne A, et al. CTNNB1 45F mutation is a molecular prognosticator of increased postoperative primary desmoid tumor recurrence: an independent, multicenter validation study. Cancer. 2013;119:3696-702 pubmed publisher
    ..With increasing implementation of "watchful-waiting" for DT management, it will be important to determine whether mutation type predicts outcome for these patients. ..
  10. Sato S, Idogawa M, Honda K, Fujii G, Kawashima H, Takekuma K, et al. Beta-catenin interacts with the FUS proto-oncogene product and regulates pre-mRNA splicing. Gastroenterology. 2005;129:1225-36 pubmed
    ..Certain mRNA splicing abbreviations seen in human cancers may be induced by the activation of the Wnt signaling pathway. ..
  11. Mårtensson A, Oberg A, Jung A, Cederquist K, Stenling R, Palmqvist R. Beta-catenin expression in relation to genetic instability and prognosis in colorectal cancer. Oncol Rep. 2007;17:447-52 pubmed
    ..01). Our results suggest that nuclear accumulation of beta-catenin in CRC is related to CIN and may be of prognostic importance. However, larger studies are needed to verify these findings. ..
  12. Hoffmeyer K, Raggioli A, Rudloff S, Anton R, Hierholzer A, Del Valle I, et al. Wnt/?-catenin signaling regulates telomerase in stem cells and cancer cells. Science. 2012;336:1549-54 pubmed publisher
    ..We uncover a previously unknown link between the stem cell and oncogenic potential whereby ?-catenin regulates Tert expression, and thereby telomere length, which could be critical in human regenerative therapy and cancer. ..
  13. Cheng C, Liu Y, Yu J, Wang H, Ding S, Hsiung C, et al. Prognostic significance of cyclin D1, ?-catenin, and MTA1 in patients with invasive ductal carcinoma of the breast. Ann Surg Oncol. 2012;19:4129-39 pubmed publisher
    ..015) using multivariate Cox regression analysis during the 10-year follow-up. Higher expression of cyclin D1, ?-catenin, and MTA1 mRNAs in breast cancers may prove effective in predicting unfavorable outcomes of breast cancer. ..
  14. McCartney B, Dierick H, Kirkpatrick C, Moline M, Baas A, Peifer M, et al. Drosophila APC2 is a cytoskeletally-associated protein that regulates wingless signaling in the embryonic epidermis. J Cell Biol. 1999;146:1303-18 pubmed
    ..Wg)/Wnt signal transduction by helping target the Wnt effector beta-catenin or its Drosophila homologue Armadillo (Arm) for destruction...
  15. Mulholland D, Read J, Rennie P, Cox M, Nelson C. Functional localization and competition between the androgen receptor and T-cell factor for nuclear beta-catenin: a means for inhibition of the Tcf signaling axis. Oncogene. 2003;22:5602-13 pubmed
    ..Together, our data strongly suggest that a reciprocal balance of nuclear beta-catenin facilitates AR-mediated repression of BCT-driven transcription and cell growth. ..
  16. Verras M, Sun Z. Beta-catenin is involved in insulin-like growth factor 1-mediated transactivation of the androgen receptor. Mol Endocrinol. 2005;19:391-8 pubmed
    ..Moreover, using a pulse-chase experiment, we showed that IGF-I enhances the stability of beta-catenin in prostate cancer cells. Our findings delineate a novel pathway for IGF-I in modulating androgen signaling through beta-catenin. ..
  17. Wahl J, Kim Y, Cullen J, Johnson K, Wheelock M. N-cadherin-catenin complexes form prior to cleavage of the proregion and transport to the plasma membrane. J Biol Chem. 2003;278:17269-76 pubmed
    ..These data suggest that a core N-cadherin-catenin complex assembles in the endoplasmic reticulum or Golgi compartment and is transported to the plasma membrane where linkage to the actin cytoskeleton can be established. ..
  18. Zeng G, Germinaro M, Micsenyi A, Monga N, Bell A, Sood A, et al. Aberrant Wnt/beta-catenin signaling in pancreatic adenocarcinoma. Neoplasia. 2006;8:279-89 pubmed
    ..Thus, Wnt/beta-catenin activation was observed in 65% of pancreatic adenocarcinomas, independently of beta-catenin gene mutations in most tumors. ..
  19. Mullen J, DeLaney T, Rosenberg A, Le L, Iafrate A, Kobayashi W, et al. β-Catenin mutation status and outcomes in sporadic desmoid tumors. Oncologist. 2013;18:1043-9 pubmed publisher
    ..CTNNB1 mutations are indeed common in sporadic desmoid tumors. However, our study did not detect a statistically significant difference in recurrence risk according to either the CTNNB1 mutation status or the specific CTNNB1 mutation. ..
  20. Xing Y, Clements W, Kimelman D, Xu W. Crystal structure of a beta-catenin/axin complex suggests a mechanism for the beta-catenin destruction complex. Genes Dev. 2003;17:2753-64 pubmed
    ..The Axin-CBD forms a helix that occupies the groove formed by the third and fourth armadillo repeats of beta-catenin and thus precludes the simultaneous binding of other beta-catenin partners in this ..
  21. Gottardi C, Gumbiner B. Distinct molecular forms of beta-catenin are targeted to adhesive or transcriptional complexes. J Cell Biol. 2004;167:339-49 pubmed
    ..This model explains how cells can control whether beta-catenin is used independently in cell adhesion and nuclear signaling, or competitively so that the two processes are coordinated and interrelated. ..
  22. Curia M, Zuckermann M, De Lellis L, Catalano T, Lattanzio R, Aceto G, et al. Sporadic childhood hepatoblastomas show activation of beta-catenin, mismatch repair defects and p53 mutations. Mod Pathol. 2008;21:7-14 pubmed
    ..Sporadic hepatoblastoma appears to be molecularly and phenotypically heterogeneous and may reflect different pathways of liver carcinogenesis. ..
  23. Xu L, Jiang Y, Zheng J, Xie G, Li J, Shi L, et al. Aberrant expression of ?-catenin and E-cadherin is correlated with poor prognosis of nasopharyngeal cancer. Hum Pathol. 2013;44:1357-64 pubmed publisher
    ..002, P = .011, respectively) regardless of TNM stage and lymph node status. In conclusion, the aberrant high expression of ?-catenin and decreased expression of E-cadherin is associated with poor prognosis in nasopharyngeal carcinoma. ..
  24. Wu G, Xu G, Schulman B, Jeffrey P, Harper J, Pavletich N. Structure of a beta-TrCP1-Skp1-beta-catenin complex: destruction motif binding and lysine specificity of the SCF(beta-TrCP1) ubiquitin ligase. Mol Cell. 2003;11:1445-56 pubmed
  25. Qi J, Chen N, Wang J, Siu C. Transendothelial migration of melanoma cells involves N-cadherin-mediated adhesion and activation of the beta-catenin signaling pathway. Mol Biol Cell. 2005;16:4386-97 pubmed
    ..Transendothelial migration was compromised in cells expressing a dominant-negative form of beta-catenin, thus supporting a regulatory role of beta-catenin signaling in this process. ..
  26. Togo N, Ohwada S, Sakurai S, Toya H, Sakamoto I, Yamada T, et al. Prognostic significance of BMP and activin membrane-bound inhibitor in colorectal cancer. World J Gastroenterol. 2008;14:4880-8 pubmed
    ..057) tended to be significant. BAMBI was linked to a potentially aggressive tumor phenotype and predicted tumor recurrence and cancer-related death in CRC. BAMBI expression might be applicable in the routine clinical setting of CRC. ..
  27. Zhang K, Zhang J, Han L, Pu P, Kang C. Wnt/beta-catenin signaling in glioma. J Neuroimmune Pharmacol. 2012;7:740-9 pubmed publisher
    ..This review reveals new insights into the role of Wnt/beta-catenin signaling in gliomagenesis, and highlights new therapeutic approaches for glioma, based on the modulation of the Wnt/beta-catenin pathway. ..
  28. Ding X, Yang Y, Han B, Du C, Xu N, Huang H, et al. Transcriptomic characterization of hepatocellular carcinoma with CTNNB1 mutation. PLoS ONE. 2014;9:e95307 pubmed publisher
    ..Our work also suggests that targeting ONECUT1, FOXA3, SSX1, and MAFG may be a valid treatment option for CTNNB1 mutation positive HCC patients. ..
  29. Iwai S, Katagiri W, Kong C, Amekawa S, Nakazawa M, Yura Y. Mutations of the APC, beta-catenin, and axin 1 genes and cytoplasmic accumulation of beta-catenin in oral squamous cell carcinoma. J Cancer Res Clin Oncol. 2005;131:773-82 pubmed
    ..In addition, the cytoplasmic accumulation of beta-catenin is a common characteristic of oral SCC, but is not closely associated with mutational alterations in the APC, beta-catenin and Axin1 genes. ..
  30. Saha B, Arase A, Imam S, Tsao Wei D, Naritoku W, Groshen S, et al. Overexpression of E-cadherin and beta-catenin proteins in metastatic prostate cancer cells in bone. Prostate. 2008;68:78-84 pubmed
  31. Medici D, Hay E, Olsen B. Snail and Slug promote epithelial-mesenchymal transition through beta-catenin-T-cell factor-4-dependent expression of transforming growth factor-beta3. Mol Biol Cell. 2008;19:4875-87 pubmed publisher
    ..These findings provide evidence for a unified signaling mechanism driven by convergence of multiple TGF-beta and TCF signaling molecules that confers loss of cell-cell adhesion and acquisition of the mesenchymal phenotype. ..
  32. Lazar A, Tuvin D, Hajibashi S, Habeeb S, Bolshakov S, Mayordomo Aranda E, et al. Specific mutations in the beta-catenin gene (CTNNB1) correlate with local recurrence in sporadic desmoid tumors. Am J Pathol. 2008;173:1518-27 pubmed publisher
    ..In conclusion, CTNNB1 mutations are highly common in desmoid tumors. Furthermore, patients harboring CTNNB1 (45F) mutations are at particular risk for recurrence and therefore may especially benefit from adjuvant therapeutic approaches. ..
  33. Finkbeiner M, Sawan C, Ouzounova M, Murr R, Herceg Z. HAT cofactor TRRAP mediates beta-catenin ubiquitination on the chromatin and the regulation of the canonical Wnt pathway. Cell Cycle. 2008;7:3908-14 pubmed
  34. Kim K, Wei Y, Szekeres C, Kugler M, Wolters P, Hill M, et al. Epithelial cell alpha3beta1 integrin links beta-catenin and Smad signaling to promote myofibroblast formation and pulmonary fibrosis. J Clin Invest. 2009;119:213-24 pubmed publisher
    ..These findings demonstrate epithelial integrin-dependent profibrotic crosstalk between beta-catenin and Smad signaling and support the hypothesis that EMT is an important contributor to pathologic fibrosis. ..
  35. Xu M, Sharma A, Hossain M, Wiest D, Sen J. Sustained expression of pre-TCR induced beta-catenin in post-beta-selection thymocytes blocks T cell development. J Immunol. 2009;182:759-65 pubmed
    ..These data are consistent with a model in which post-beta-selection, pre-TCR-induced beta-catenin expression must return to background levels for efficient transition to the DP stage. ..
  36. Humtsoe J, Liu M, Malik A, Wary K. Lipid phosphate phosphatase 3 stabilization of beta-catenin induces endothelial cell migration and formation of branching point structures. Mol Cell Biol. 2010;30:1593-606 pubmed publisher
    ..Thus, our study identified a key role for LPP3 in orchestrating PTEN-mediated beta-catenin/LEF-1 signaling in EC migration, cell-cell adhesion, and formation of branching point structures. ..
  37. Barker N, Hurlstone A, Musisi H, Miles A, Bienz M, Clevers H. The chromatin remodelling factor Brg-1 interacts with beta-catenin to promote target gene activation. EMBO J. 2001;20:4935-43 pubmed
    ..We conclude that beta-catenin recruits Brg-1 to Tcf target gene promoters, facilitating chromatin remodelling as a prerequisite for transcriptional activation. ..
  38. Liu L, Jiang X, Zhou X, Wang D, Song X, Jiang H. Upregulation of vimentin and aberrant expression of E-cadherin/beta-catenin complex in oral squamous cell carcinomas: correlation with the clinicopathological features and patient outcome. Mod Pathol. 2010;23:213-24 pubmed publisher
    ..The combination of the upregulation of vimentin and aberrant expression of E-cadherin/beta-catenin complexes at the tumour invasive front may provide a useful prognostic marker in oral squamous cell carcinoma. ..
  39. Elzagheid A, Buhmeida A, Korkeila E, Collan Y, Syrjanen K, Pyrhonen S. Nuclear beta-catenin expression as a prognostic factor in advanced colorectal carcinoma. World J Gastroenterol. 2008;14:3866-71 pubmed
    ..041) and DSS (P = 0.046). Nuclear beta-catenin expression provides additional information in predicting patient outcome in advanced CRC. ..
  40. Tadjine M, Lampron A, Ouadi L, Bourdeau I. Frequent mutations of beta-catenin gene in sporadic secreting adrenocortical adenomas. Clin Endocrinol (Oxf). 2008;68:264-70 pubmed
    ..To better understand the role of Wnt/beta-catenin signalling in adrenocortical tumours, we performed mutational analysis of the beta-catenin gene...
  41. Yang L, Lin C, Liu Z. P68 RNA helicase mediates PDGF-induced epithelial mesenchymal transition by displacing Axin from beta-catenin. Cell. 2006;127:139-55 pubmed
    ..These data demonstrated a novel mechanism of phosphor-p68 in mediating the growth factor-induced EMT and uncovered a new pathway to promote beta-catenin nuclear translocation. ..
  42. Horst D, Reu S, Kriegl L, Engel J, Kirchner T, Jung A. The intratumoral distribution of nuclear beta-catenin is a prognostic marker in colon cancer. Cancer. 2009;115:2063-70 pubmed publisher
  43. Playford M, Bicknell D, Bodmer W, Macaulay V. Insulin-like growth factor 1 regulates the location, stability, and transcriptional activity of beta-catenin. Proc Natl Acad Sci U S A. 2000;97:12103-8 pubmed
    ..In conclusion, we have shown that IGF-1 causes tyrosine phosphorylation and stabilization of beta-catenin. These effects may contribute to transformation, cell migration, and a propensity for metastasis in vivo. ..
  44. Hommura F, Furuuchi K, Yamazaki K, Ogura S, Kinoshita I, Shimizu M, et al. Increased expression of beta-catenin predicts better prognosis in nonsmall cell lung carcinomas. Cancer. 2002;94:752-8 pubmed
  45. Tian Y, Phillips A. Interaction between the transforming growth factor-beta type II receptor/Smad pathway and beta-catenin during transforming growth factor-beta1-mediated adherens junction disassembly. Am J Pathol. 2002;160:1619-28 pubmed
    ..Furthermore after receptor ligand binding, beta-catenin became associated with the TGF-beta 1-signaling molecules Smad3 and Smad4. ..
  46. Ishitani T, Kishida S, Hyodo Miura J, Ueno N, Yasuda J, Waterman M, et al. The TAK1-NLK mitogen-activated protein kinase cascade functions in the Wnt-5a/Ca(2+) pathway to antagonize Wnt/beta-catenin signaling. Mol Cell Biol. 2003;23:131-9 pubmed
    ..These results suggest that the TAK1-NLK MAPK cascade is activated by the noncanonical Wnt-5a/Ca(2+) pathway and antagonizes canonical Wnt/beta-catenin signaling. ..
  47. Ragazzon B, Libe R, Gaujoux S, Assie G, Fratticci A, Launay P, et al. Transcriptome analysis reveals that p53 and {beta}-catenin alterations occur in a group of aggressive adrenocortical cancers. Cancer Res. 2010;70:8276-81 pubmed publisher
    ..This study shows the important respective roles of p53 and ?-catenin in ACC development, delineating subgroups of ACC with different tumorigenesis and outcomes. ..
  48. Su Y, Fu C, Ishikawa S, Stella A, Kojima M, Shitoh K, et al. APC is essential for targeting phosphorylated beta-catenin to the SCFbeta-TrCP ubiquitin ligase. Mol Cell. 2008;32:652-61 pubmed publisher
    ..Thus, by acting to protect the E3 ligase binding site, APC ensures the ubiquitin conjugation of phosphorylated beta-catenin. ..
  49. Yaguchi T, Goto Y, Kido K, Mochimaru H, Sakurai T, Tsukamoto N, et al. Immune suppression and resistance mediated by constitutive activation of Wnt/?-catenin signaling in human melanoma cells. J Immunol. 2012;189:2110-7 pubmed publisher
  50. Fuchs M, Muller T, Lerch M, Ullrich A. Association of human protein-tyrosine phosphatase kappa with members of the armadillo family. J Biol Chem. 1996;271:16712-9 pubmed
  51. Ikeda S, Ishizaki Y, Shimizu Y, Fujimori M, Ojima Y, Okajima M, et al. Immunohistochemistry of cyclin D1 and beta-catenin, and mutational analysis of exon 3 of beta-catenin gene in parathyroid adenomas. Int J Oncol. 2002;20:463-6 pubmed
    ..These results indicate that cyclin D1 is frequently accumulated in parathyroid adenomas, independently of dysfunction in the Wnt signaling pathway. ..
  52. Kishida S, Yamamoto H, Hino S, Ikeda S, Kishida M, Kikuchi A. DIX domains of Dvl and axin are necessary for protein interactions and their ability to regulate beta-catenin stability. Mol Cell Biol. 1999;19:4414-22 pubmed
    ..These results indicate that the DIX domains of Dvl-1 and Axin are important for protein-protein interactions and that they are necessary for the ability of Dvl-1 and Axin to regulate the stability of beta-catenin. ..
  53. Maher M, Flozak A, Stocker A, Chenn A, Gottardi C. Activity of the beta-catenin phosphodestruction complex at cell-cell contacts is enhanced by cadherin-based adhesion. J Cell Biol. 2009;186:219-28 pubmed publisher
  54. Truica C, Byers S, Gelmann E. Beta-catenin affects androgen receptor transcriptional activity and ligand specificity. Cancer Res. 2000;60:4709-13 pubmed
    ..The amount of beta-catenin in complex with AR was increased by androgen. These findings implicate beta-catenin in the regulation of AR function and support a role for beta-catenin mutations in the pathogenesis of prostate cancer. ..
  55. Teng Y, Wang X, Wang Y, Ma D. Wnt/beta-catenin signaling regulates cancer stem cells in lung cancer A549 cells. Biochem Biophys Res Commun. 2010;392:373-9 pubmed publisher
    ..Taken together, our study provides strong evidence that canonical Wnt signaling plays an important role in lung cancer stem cell properties, and it also regulates OCT-4, a lung cancer stem cell marker. ..
  56. Abd El Rehim D, Ali M. Aberrant expression of ?-catenin in invasive ductal breast carcinomas. J Egypt Natl Canc Inst. 2009;21:185-95 pubmed
    ..These results may offer new insights regarding the role of ?-catenin in breast cancer. ..
  57. Flahaut M, Meier R, Coulon A, Nardou K, Niggli F, Martinet D, et al. The Wnt receptor FZD1 mediates chemoresistance in neuroblastoma through activation of the Wnt/beta-catenin pathway. Oncogene. 2009;28:2245-56 pubmed publisher
    ..Our data represent the first implication of the Wnt/beta-catenin pathway in NB chemoresistance and identify potential new targets to treat aggressive and resistant NB. ..
  58. Mizusaki H, Kawabe K, Mukai T, Ariyoshi E, Kasahara M, Yoshioka H, et al. Dax-1 (dosage-sensitive sex reversal-adrenal hypoplasia congenita critical region on the X chromosome, gene 1) gene transcription is regulated by wnt4 in the female developing gonad. Mol Endocrinol. 2003;17:507-19 pubmed
    ..We thus conclude that Wnt4 signaling mediates the increased expression of Dax-1 as the ovary becomes sexually differentiated. ..
  59. Yamashita T, Budhu A, Forgues M, Wang X. Activation of hepatic stem cell marker EpCAM by Wnt-beta-catenin signaling in hepatocellular carcinoma. Cancer Res. 2007;67:10831-9 pubmed
  60. Sinnberg T, Menzel M, Ewerth D, Sauer B, Schwarz M, Schaller M, et al. ?-Catenin signaling increases during melanoma progression and promotes tumor cell survival and chemoresistance. PLoS ONE. 2011;6:e23429 pubmed publisher
    ..The differential requirements for beta-catenin signaling in aggressive melanoma versus benign melanocytic cells make beta-catenin a possible new target in melanoma therapy. ..
  61. Gerstein A, Almeida T, Zhao G, Chess E, Shih I, Buhler K, et al. APC/CTNNB1 (beta-catenin) pathway alterations in human prostate cancers. Genes Chromosomes Cancer. 2002;34:9-16 pubmed
    ..These results suggest that CTNNB1 signaling plays a critical role in the development of a significant fraction of prostate cancers. Moreover, they provide the first evidence that hTRCP1 plays a role in human neoplasia. ..
  62. Pishvaian M, Feltes C, Thompson P, Bussemakers M, Schalken J, Byers S. Cadherin-11 is expressed in invasive breast cancer cell lines. Cancer Res. 1999;59:947-52 pubmed
  63. Yang M, Zhong W, Srivastava N, Slavin A, Yang J, Hoey T, et al. G protein-coupled lysophosphatidic acid receptors stimulate proliferation of colon cancer cells through the {beta}-catenin pathway. Proc Natl Acad Sci U S A. 2005;102:6027-32 pubmed
    ..Thus, LPA(2) and LPA(3) signal the proliferation of colon cancer cells through cPKC-mediated activation of the beta-catenin pathway. These results link LPA and its GPCRs to cancer through a major oncogenic signaling pathway. ..
  64. Wang W, Xue L, Liu H, Wang P, Xu P, Cai Y. Aberrant changes of Wnt2/beta-catenin signaling pathway induced by sodium nitroprusside in human esophageal squamous cell carcinoma cell lines. Cancer Invest. 2010;28:230-41 pubmed publisher
  65. Miao Y, Li A, Wang L, Fan C, Zhang X, Xu H, et al. Expression of p130cas, E-cadherin and ?-catenin and their correlation with clinicopathological parameters in non-small cell lung cancer: p130cas over-expression predicts poor prognosis. Folia Histochem Cytobiol. 2012;50:392-7 pubmed publisher
    ..These results indicate that p130cas may impact a variety of clinicopathological features of NSCLC and may y influence the prognosis of lung cancer patients. ..
  66. Widlund H, Horstmann M, Price E, Cui J, Lessnick S, Wu M, et al. Beta-catenin-induced melanoma growth requires the downstream target Microphthalmia-associated transcription factor. J Cell Biol. 2002;158:1079-87 pubmed
    ..Thus, beta-catenin regulation of MITF expression represents a tissue-restricted pathway that significantly influences the growth and survival behavior of this notoriously treatment-resistant neoplasm. ..
  67. Ito K, Lim A, Salto Tellez M, Motoda L, Osato M, Chuang L, et al. RUNX3 attenuates beta-catenin/T cell factors in intestinal tumorigenesis. Cancer Cell. 2008;14:226-37 pubmed publisher
    ..Taken together, these data demonstrate that RUNX3 functions as a tumor suppressor by attenuating Wnt signaling. ..
  68. Mahmoudi T, Li V, Ng S, Taouatas N, Vries R, Mohammed S, et al. The kinase TNIK is an essential activator of Wnt target genes. EMBO J. 2009;28:3329-40 pubmed publisher
    ..This kinase may present an attractive candidate for drug targeting in colorectal cancer. ..
  69. Monga S, Mars W, Pediaditakis P, Bell A, Mulè K, Bowen W, et al. Hepatocyte growth factor induces Wnt-independent nuclear translocation of beta-catenin after Met-beta-catenin dissociation in hepatocytes. Cancer Res. 2002;62:2064-71 pubmed
    ..Part of the multifunctionality of HGF might be attributable to nuclear beta-catenin and the resulting target gene expression. ..
  70. Ishitani T, Ninomiya Tsuji J, Matsumoto K. Regulation of lymphoid enhancer factor 1/T-cell factor by mitogen-activated protein kinase-related Nemo-like kinase-dependent phosphorylation in Wnt/beta-catenin signaling. Mol Cell Biol. 2003;23:1379-89 pubmed
    ..These results suggest that NLK phosphorylation on these sites contributes to the down-regulation of LEF-1/TCF transcriptional activity. ..
  71. Romiti A, Zullo A, Borrini F, Sarcina I, Hassan C, Winn S, et al. Relationship between beta-catenin expression and epithelial cell proliferation in gastric mucosa with intestinal metaplasia. World J Gastroenterol. 2005;11:4400-3 pubmed
    ..The intranuclear localization of beta-catenin increases cell proliferation. H pylori infection does not seem to play a direct role in beta-catenin alterations, whilst it significantly increases cell proliferation. ..
  72. Xing Y, Takemaru K, Liu J, Berndt J, Zheng J, Moon R, et al. Crystal structure of a full-length beta-catenin. Structure. 2008;16:478-87 pubmed publisher
    ..structures of full-length zebrafish beta-catenin and a human beta-catenin fragment that contains both the armadillo repeat and the C-terminal domains...
  73. Harris E, Nelson W. Adenomatous polyposis coli regulates endothelial cell migration independent of roles in beta-catenin signaling and cell-cell adhesion. Mol Biol Cell. 2010;21:2611-23 pubmed publisher
    ..These results uncouple different APC functions and show that GSK3 beta/CKI phosphorylation regulates APC clusters and cell migration independently of cell-cell adhesion and beta-catenin transcriptional activity. ..
  74. Tien L, Ito M, Nakao M, Niino D, Serik M, Nakashima M, et al. Expression of beta-catenin in hepatocellular carcinoma. World J Gastroenterol. 2005;11:2398-401 pubmed
    ..The beta-catenin expression in HCC cells was heterogeneous among types of hepatitis viral infection. Wnt signaling pathway might be deeply involved in less-differentiated HCC and HBV background. ..
  75. Lüchtenborg M, Weijenberg M, Wark P, Saritas A, Roemen G, Van Muijen G, et al. Mutations in APC, CTNNB1 and K-ras genes and expression of hMLH1 in sporadic colorectal carcinomas from the Netherlands Cohort Study. BMC Cancer. 2005;5:160 pubmed
    ..CTNNB1 mutations seem to be of minor importance in sporadic colorectal cancer. The main differences in tumour and patient characteristics are found between groups of patients based on mismatch repair deficiency. ..
  76. Iioka H, Doerner S, Tamai K. Kaiso is a bimodal modulator for Wnt/beta-catenin signaling. FEBS Lett. 2009;583:627-32 pubmed publisher
    ..Our studies together provide insights into why Kaiso null mice display resistance to intestinal tumors when crossed onto an Apc(Min/+) background. ..
  77. Varelas X, Miller B, Sopko R, Song S, Gregorieff A, Fellouse F, et al. The Hippo pathway regulates Wnt/beta-catenin signaling. Dev Cell. 2010;18:579-91 pubmed publisher
    ..These results uncover a cytoplasmic function of TAZ in regulating Wnt signaling and highlight the role of the Hippo pathway in coordinating morphogenetic signaling with growth control. ..
  78. Han J, Soletti R, Sadarangani A, Sridevi P, Ramirez M, Eckmann L, et al. Nuclear expression of ?-catenin promotes RB stability and resistance to TNF-induced apoptosis in colon cancer cells. Mol Cancer Res. 2013;11:207-18 pubmed publisher
    ..Together, these results suggest that nuclear ?-catenin-dependent RB stabilization suppresses TNF-induced apoptosis in caspase-8-positive colon cancer cells. ..
  79. Huiping C, Kristjansdottir S, Jonasson J, Magnusson J, Egilsson V, Ingvarsson S. Alterations of E-cadherin and beta-catenin in gastric cancer. BMC Cancer. 2001;1:16 pubmed
    ..Our results support the hypothesis that alterations of E-cadherin and beta-catenin play a role in the initiation and progression of gastric cancer. ..
  80. Song L, Herrell R, Byers S, Shah S, Wilson E, Gelmann E. Beta-catenin binds to the activation function 2 region of the androgen receptor and modulates the effects of the N-terminal domain and TIF2 on ligand-dependent transcription. Mol Cell Biol. 2003;23:1674-87 pubmed
    ..Mutational disruption of each of five LXXLL peptide motifs in the beta-catenin armadillo repeats did not disrupt either binding to androgen receptor or transcriptional coactivation...
  81. Fang D, Hawke D, Zheng Y, Xia Y, Meisenhelder J, Nika H, et al. Phosphorylation of beta-catenin by AKT promotes beta-catenin transcriptional activity. J Biol Chem. 2007;282:11221-9 pubmed
    ..Phosphorylation of beta-catenin by AKT increases its transcriptional activity and promotes tumor cell invasion, indicating that AKT-dependent regulation of beta-catenin plays a critical role in tumor invasion and development. ..
  82. Wanitsuwan W, Kanngurn S, Boonpipattanapong T, Sangthong R, Sangkhathat S. Overall expression of beta-catenin outperforms its nuclear accumulation in predicting outcomes of colorectal cancers. World J Gastroenterol. 2008;14:6052-9 pubmed
    ..Instead, the overall expression of beta-catenin in CRC showed an association with better differentiation and earlier staging. Moreover, the parameter also independently predicted superior survival. ..
  83. Sun Z, Cao X, Jiang M, Qiu Y, Zhou H, Chen L, et al. Inhibition of ?-catenin signaling by nongenomic action of orphan nuclear receptor Nur77. Oncogene. 2012;31:2653-67 pubmed publisher
    ..Together, our results demonstrate that ?-catenin can be degraded by cytoplasmic Nur77 through their interaction and identify H-9 and ATE-i2-b4 as potent activators of the Nur77-mediated pathway for ?-catenin degradation. ..
  84. Sadot E, Conacci Sorrell M, Zhurinsky J, Shnizer D, Lando Z, Zharhary D, et al. Regulation of S33/S37 phosphorylated beta-catenin in normal and transformed cells. J Cell Sci. 2002;115:2771-80 pubmed
  85. Coussen F, Normand E, Marchal C, Costet P, Choquet D, Lambert M, et al. Recruitment of the kainate receptor subunit glutamate receptor 6 by cadherin/catenin complexes. J Neurosci. 2002;22:6426-36 pubmed
    ..These results suggest an important role for cadherin/catenin complexes in the stabilization of kainate receptors at the synaptic membrane during synapse formation and remodeling. ..
  86. Easwaran V, Lee S, Inge L, Guo L, Goldbeck C, Garrett E, et al. beta-Catenin regulates vascular endothelial growth factor expression in colon cancer. Cancer Res. 2003;63:3145-53 pubmed
    ..Taken together, our observations indicate a close link between beta-catenin signaling and the regulation of VEGF-A expression in colon cancer. ..
  87. Zhang M, Wang M, Tan X, Li T, Zhang Y, Chen D. Smad3 prevents beta-catenin degradation and facilitates beta-catenin nuclear translocation in chondrocytes. J Biol Chem. 2010;285:8703-10 pubmed publisher
    ..Our findings demonstrate a novel mechanism between TGF-beta and Wnt/beta-catenin signaling pathways during chondrocyte development. ..
  88. Lee G, Goretsky T, Managlia E, Dirisina R, Singh A, Brown J, et al. Phosphoinositide 3-kinase signaling mediates beta-catenin activation in intestinal epithelial stem and progenitor cells in colitis. Gastroenterology. 2010;139:869-81, 881.e1-9 pubmed publisher
    ..PI3K-induced and Akt-mediated beta-catenin signaling are required for progenitor cell activation during the progression from CUC to CAC; these factors might be used as biomarkers of dysplastic transformation in the colon. ..
  89. Chairoungdua A, SMITH D, Pochard P, Hull M, Caplan M. Exosome release of ?-catenin: a novel mechanism that antagonizes Wnt signaling. J Cell Biol. 2010;190:1079-91 pubmed publisher
    ..Thus, exosomal packaging and release of cytosolic proteins can modulate the activity of cellular signaling pathways. ..
  90. Albuquerque C, Breukel C, van der Luijt R, Fidalgo P, Lage P, Slors F, et al. The 'just-right' signaling model: APC somatic mutations are selected based on a specific level of activation of the beta-catenin signaling cascade. Hum Mol Genet. 2002;11:1549-60 pubmed
    ..We propose that this selection process is aimed at a specific degree of beta-catenin signaling optimal for tumor formation, rather than at its constitutive activation by deletion of all of the beta-catenin downregulating motifs in APC. ..
  91. Ysebaert L, Chicanne G, Demur C, De Toni F, Prade Houdellier N, Ruidavets J, et al. Expression of beta-catenin by acute myeloid leukemia cells predicts enhanced clonogenic capacities and poor prognosis. Leukemia. 2006;20:1211-6 pubmed
    ..Altogether, our data pave the way to the evaluation of Wnt pathway inhibition as a new rationale for eradicating the clonogenic pool of AML cells. ..